alendronate has been researched along with Gaucher Disease in 1 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Gaucher Disease: An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alendronate is a useful adjunctive therapy in combination with enzyme replacement therapy (ERT) for the treatment of GD-related osteopenia in adults, but it cannot be expected to improve focal lesions." | 6.71 | Gaucher disease: alendronate disodium improves bone mineral density in adults receiving enzyme therapy. ( Bailey, L; Grabowski, GA; Moskovitz, J; Oestreich, AE; Sun, S; Wenstrup, RJ; Wu, W, 2004) |
| "Alendronate is a useful adjunctive therapy in combination with enzyme replacement therapy (ERT) for the treatment of GD-related osteopenia in adults, but it cannot be expected to improve focal lesions." | 2.71 | Gaucher disease: alendronate disodium improves bone mineral density in adults receiving enzyme therapy. ( Bailey, L; Grabowski, GA; Moskovitz, J; Oestreich, AE; Sun, S; Wenstrup, RJ; Wu, W, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wenstrup, RJ | 1 |
| Bailey, L | 1 |
| Grabowski, GA | 1 |
| Moskovitz, J | 1 |
| Oestreich, AE | 1 |
| Wu, W | 1 |
| Sun, S | 1 |
1 trial available for alendronate and Gaucher Disease
| Article | Year |
|---|---|
Gaucher disease: alendronate disodium improves bone mineral density in adults receiving enzyme therapy.
Topics: Adult; Alendronate; beta-Glucosidase; Bone Density; Double-Blind Method; Drug Therapy, Combination; | 2004 |