alendronate has been researched along with Gastrointestinal Hemorrhage in 7 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients receiving alendronate for osteoporosis carry a significantly higher risk of developing upper gastrointestinal bleeding (GIB) and lower GIB (hazard ratio 1." | 3.80 | Alendronate, a bisphosphonate, increased upper and lower gastrointestinal bleeding: risk factor analysis from a nationwide population-based study. ( Hou, MC; Hu, HY; Lee, FY; Lin, HC; Luo, JC; Peng, YL, 2014) |
| "Isolated case reports of gastric ulcers after alendronate sodium use raised concern about the gastroduodenal safety of daily alendronate." | 3.71 | Gastric and duodenal safety of daily alendronate. ( Andrade, SE; Beck, A; Boles, M; Buist, DS; Carey, VJ; Chan, KA; Chandler, JM; Chase, GA; Donahue, JG; Ettinger, B; Fishman, P; Goodman, M; Guess, HA; Gurwitz, JH; LaCroix, AZ; Levin, TR; Platt, R, 2002) |
| " Although these agents are generally well tolerated, serious gastrointestinal adverse events, including hospitalization for gastrointestinal bleed, may arise." | 1.35 | Comparative gastrointestinal safety of weekly oral bisphosphonates. ( Brookhart, MA; Cadarette, SM; Katz, JN; Levin, R; Solomon, DH; Stedman, MR; Stürmer, T, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, YL | 1 |
| Hu, HY | 1 |
| Luo, JC | 1 |
| Hou, MC | 1 |
| Lin, HC | 1 |
| Lee, FY | 1 |
| Connolly, JG | 1 |
| Gagne, JJ | 1 |
| Cadarette, SM | 1 |
| Katz, JN | 1 |
| Brookhart, MA | 1 |
| Stürmer, T | 1 |
| Stedman, MR | 1 |
| Levin, R | 1 |
| Solomon, DH | 1 |
| Katz, MH | 1 |
| Sawhney, MS | 1 |
| Nelson, DB | 1 |
| Kaye, PS | 1 |
| Donahue, JG | 1 |
| Chan, KA | 1 |
| Andrade, SE | 1 |
| Beck, A | 1 |
| Boles, M | 1 |
| Buist, DS | 1 |
| Carey, VJ | 1 |
| Chandler, JM | 1 |
| Chase, GA | 1 |
| Ettinger, B | 1 |
| Fishman, P | 1 |
| Goodman, M | 1 |
| Guess, HA | 1 |
| Gurwitz, JH | 1 |
| LaCroix, AZ | 1 |
| Levin, TR | 1 |
| Platt, R | 1 |
7 other studies available for alendronate and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Alendronate, a bisphosphonate, increased upper and lower gastrointestinal bleeding: risk factor analysis from a nationwide population-based study.
Topics: Age Factors; Aged; Aged, 80 and over; Alendronate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 2014 |
Comparison of Calipers for Matching on the Disease Risk Score.
Topics: Aged; Aged, 80 and over; Alendronate; Anti-Inflammatory Agents, Non-Steroidal; Bone Density Conserva | 2016 |
Comparative gastrointestinal safety of weekly oral bisphosphonates.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alendronate; Bone Density Conservation Agents; Diphos | 2009 |
Opportunities to decrease inappropriate uses of proton pump inhibitors: Comment on "Proton pump inhibitor use and the antifracture efficacy of alendronate".
Topics: Alendronate; Bone Density Conservation Agents; Denmark; Dose-Response Relationship, Drug; Drug Inter | 2011 |
Alendronate-induced colon ulcers: case report of a new clinical entity.
Topics: Aged; Alendronate; Biopsy; Cecal Diseases; Cecum; Colon; Colonic Diseases; Colonoscopy; Diagnosis, D | 2004 |
Gastric hemorrhage and ulceration in hiatal hernia sac associated with alendronate.
Topics: Aged; Aged, 80 and over; Alendronate; Esophageal Diseases; Female; Gastrointestinal Hemorrhage; Hern | 1999 |
Gastric and duodenal safety of daily alendronate.
Topics: Adult; Aged; Aged, 80 and over; Alendronate; Cohort Studies; Duodenal Diseases; Duodenal Ulcer; Fema | 2002 |