alendronate has been researched along with Chondrosarcoma in 2 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Chondrosarcoma: A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of different concentrations of alendronate on cell proliferation, migration, apoptosis and cytoskeleton reorganization as well as on the regulation of intracellular protein expression were analyzed for the high-grade chondrosarcoma cell line CS-1." | 7.75 | Alendronate inhibits growth of high-grade chondrosarcoma cells. ( Horiuchi, K; Hornicek, FJ; Morii, T; Morioka, H; Susa, M; Toyama, Y; Weissbach, L; Yabe, H, 2009) |
| "Our findings suggest that alendronate may reduce MMP-2 secretion at the transcriptional and translational levels, and inhibit the invasion of chondrosarcoma cell." | 7.74 | Alendronate inhibits cell invasion and MMP-2 secretion in human chondrosarcoma cell line. ( Chou, MC; Fong, YC; Hsu, CJ; Hsu, HC; Hsu, SF; Lai, TJ; Lee, MC; Li, TM; Lin, JG; Yang, SF, 2007) |
| "The effect of different concentrations of alendronate on cell proliferation, migration, apoptosis and cytoskeleton reorganization as well as on the regulation of intracellular protein expression were analyzed for the high-grade chondrosarcoma cell line CS-1." | 3.75 | Alendronate inhibits growth of high-grade chondrosarcoma cells. ( Horiuchi, K; Hornicek, FJ; Morii, T; Morioka, H; Susa, M; Toyama, Y; Weissbach, L; Yabe, H, 2009) |
| "Our findings suggest that alendronate may reduce MMP-2 secretion at the transcriptional and translational levels, and inhibit the invasion of chondrosarcoma cell." | 3.74 | Alendronate inhibits cell invasion and MMP-2 secretion in human chondrosarcoma cell line. ( Chou, MC; Fong, YC; Hsu, CJ; Hsu, HC; Hsu, SF; Lai, TJ; Lee, MC; Li, TM; Lin, JG; Yang, SF, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Susa, M | 1 |
| Morii, T | 1 |
| Yabe, H | 1 |
| Horiuchi, K | 1 |
| Toyama, Y | 1 |
| Weissbach, L | 1 |
| Hornicek, FJ | 1 |
| Morioka, H | 1 |
| Lai, TJ | 1 |
| Hsu, SF | 1 |
| Li, TM | 1 |
| Hsu, HC | 1 |
| Lin, JG | 1 |
| Hsu, CJ | 1 |
| Chou, MC | 1 |
| Lee, MC | 1 |
| Yang, SF | 1 |
| Fong, YC | 1 |
2 other studies available for alendronate and Chondrosarcoma
| Article | Year |
|---|---|
Alendronate inhibits growth of high-grade chondrosarcoma cells.
Topics: Alendronate; Blotting, Western; Bone Density Conservation Agents; Bone Neoplasms; Cell Adhesion; Cel | 2009 |
Alendronate inhibits cell invasion and MMP-2 secretion in human chondrosarcoma cell line.
Topics: Alendronate; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Chondrosarcoma; Humans; | 2007 |