alendronate has been researched along with Cardiomegaly in 4 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In our previous study, farnesyl pyrophosphate synthase (FPPS) was shown to be increased in spontaneously hypertensive rats (SHR) and in mice with angiotensin-II induced cardiac hypertrophy." | 3.83 | Alteration of RhoA Prenylation Ameliorates Cardiac and Vascular Remodeling in Spontaneously Hypertensive Rats. ( Chen, YN; Mou, Y; Xu, ZX; Yang, J; Zheng, LR, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, J | 2 |
| Chen, YN | 1 |
| Xu, ZX | 1 |
| Mou, Y | 2 |
| Zheng, LR | 1 |
| Ye, Y | 3 |
| Hu, SJ | 3 |
| Li, L | 2 |
| Chen, GP | 2 |
| Yang, Y | 1 |
| Yao, L | 1 |
| Zhu, HH | 1 |
| Zhao, CZ | 1 |
4 other studies available for alendronate and Cardiomegaly
| Article | Year |
|---|---|
Alteration of RhoA Prenylation Ameliorates Cardiac and Vascular Remodeling in Spontaneously Hypertensive Rats.
Topics: Alendronate; Animals; Aorta; Blood Pressure; Bone Density Conservation Agents; Cardiomegaly; Collage | 2016 |
Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway.
Topics: Alendronate; Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Dimethylallyltranstransferase; | 2009 |
Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats.
Topics: Alendronate; Animals; Cardiomegaly; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrosis; G | 2010 |
Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo.
Topics: Alendronate; Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiomegaly; Contraindications; Fi | 2013 |