alendronate has been researched along with Cardiac Hypertrophy in 4 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In our previous study, farnesyl pyrophosphate synthase (FPPS) was shown to be increased in spontaneously hypertensive rats (SHR) and in mice with angiotensin-II induced cardiac hypertrophy." | 3.83 | Alteration of RhoA Prenylation Ameliorates Cardiac and Vascular Remodeling in Spontaneously Hypertensive Rats. ( Chen, YN; Mou, Y; Xu, ZX; Yang, J; Zheng, LR, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, J | 2 |
| Chen, YN | 1 |
| Xu, ZX | 1 |
| Mou, Y | 2 |
| Zheng, LR | 1 |
| Ye, Y | 3 |
| Hu, SJ | 3 |
| Li, L | 2 |
| Chen, GP | 2 |
| Yang, Y | 1 |
| Yao, L | 1 |
| Zhu, HH | 1 |
| Zhao, CZ | 1 |
4 other studies available for alendronate and Cardiac Hypertrophy
| Article | Year |
|---|---|
Alteration of RhoA Prenylation Ameliorates Cardiac and Vascular Remodeling in Spontaneously Hypertensive Rats.
Topics: Alendronate; Animals; Aorta; Blood Pressure; Bone Density Conservation Agents; Cardiomegaly; Collage | 2016 |
Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway.
Topics: Alendronate; Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Dimethylallyltranstransferase; | 2009 |
Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats.
Topics: Alendronate; Animals; Cardiomegaly; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrosis; G | 2010 |
Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo.
Topics: Alendronate; Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiomegaly; Contraindications; Fi | 2013 |