alendronate has been researched along with Arthritis, Degenerative in 23 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To summarize the recent development on chondroprotective effect of alendronate (ALN) on articular cartilage in osteoarthritis (OA)." | 8.88 | [Research progress of protective effects of alendronate on articular cartilage in osteoarthritis]. ( He, D; Luo, Y; Wei, Q; Yin, M, 2012) |
| "This study aimed to evaluate the effects of intra-articular injection of alendronate to osteoarthritis, which has a protective effect on bone and cartilage tissue and helps reduce inflammation in temporomandibular joint osteoarthritis." | 8.31 | Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis. ( Acibadem, E; Bozdag, Z; Keskinruzgar, A; Yavuz, GY, 2023) |
| "To employ elemental Strontium as a tracer of bone turnover, in the presence (or absence) of the bisphosphonate drug Alendronate, in order to spatially map osteophytogenesis and other bone turnover in rats developing post-traumatic secondary osteoarthritis (PTOA)." | 7.78 | Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. ( Doschak, MR; Maksymowych, WP; Panahifar, A, 2012) |
| "To evaluate the effects of alendronate (ALN) on the subchondral bone quality and cartilage degeneration in the early phase of experimental model of osteoarthritis after anterior cruciate ligament transaction (ACLT)." | 7.77 | Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental osteoarthritis. ( Hu, H; Song, H; Tian, F; Zhang, L; Zhang, Y, 2011) |
| "Alendronate (ALN) is a potent inhibitor of osteoclastic bone resorption and results in reduced bone remodeling." | 5.40 | Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression. ( de Blois, E; de Jong, M; Groen, HC; Koelewijn, SJ; Müller, C; Siebelt, M; Verhaar, JA; Waarsing, JH; Weinans, H, 2014) |
| "To summarize the recent development on chondroprotective effect of alendronate (ALN) on articular cartilage in osteoarthritis (OA)." | 4.88 | [Research progress of protective effects of alendronate on articular cartilage in osteoarthritis]. ( He, D; Luo, Y; Wei, Q; Yin, M, 2012) |
| "This study aimed to evaluate the effects of intra-articular injection of alendronate to osteoarthritis, which has a protective effect on bone and cartilage tissue and helps reduce inflammation in temporomandibular joint osteoarthritis." | 4.31 | Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis. ( Acibadem, E; Bozdag, Z; Keskinruzgar, A; Yavuz, GY, 2023) |
| "Mechanical loading and alendronate (ALN) can be used as noninvasive physical therapy methods for osteoarthritis (OA)." | 4.31 | Axial Compressive Loading Attenuates Early Osteoarthritis by Reducing Subchondral Bone Remodeling. ( Cai, H; Fu, L; Li, G; Liu, C; Liu, Q; Liu, Y; Pan, Y; Wu, J; Yang, Q; Yu, Y; Zhong, J, 2023) |
| "To investigate the disease modifying effects of cathepsin K (CatK) inhibitor L-006235 compared to alendronate (ALN) in two preclinical models of osteoarthritis (OA)." | 3.78 | Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. ( Duong, LT; Hayami, T; Pickarski, M; Wesolowski, GA; Zhuo, Y, 2012) |
| "To employ elemental Strontium as a tracer of bone turnover, in the presence (or absence) of the bisphosphonate drug Alendronate, in order to spatially map osteophytogenesis and other bone turnover in rats developing post-traumatic secondary osteoarthritis (PTOA)." | 3.78 | Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. ( Doschak, MR; Maksymowych, WP; Panahifar, A, 2012) |
| "To evaluate the effects of alendronate (ALN) on the subchondral bone quality and cartilage degeneration in the early phase of experimental model of osteoarthritis after anterior cruciate ligament transaction (ACLT)." | 3.77 | Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental osteoarthritis. ( Hu, H; Song, H; Tian, F; Zhang, L; Zhang, Y, 2011) |
| "To examine the effects of alendronate (ALN) on IL-1beta-stimulated chondrocyte of rabbit in vitro and on cartilage and subchondral bone in rabbit osteoarthritis (OA) induced by anterior cruciate ligament transection (ACLT)." | 3.75 | [In vitro effect of alendronate on chondrocytes and articular cartilage and subchondral bone in rabbit anterior cruciate ligament transection model]. ( Cheng, T; Hu, H; Li, B; Liu, X; Tian, F; Wang, Z; Zhang, L; Zhang, Y, 2009) |
| "Alendronate (ALN) is a potent inhibitor of osteoclastic bone resorption and results in reduced bone remodeling." | 1.40 | Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression. ( de Blois, E; de Jong, M; Groen, HC; Koelewijn, SJ; Müller, C; Siebelt, M; Verhaar, JA; Waarsing, JH; Weinans, H, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 13 (56.52) | 24.3611 |
| 2020's | 6 (26.09) | 2.80 |
| Authors | Studies |
|---|---|
| Acibadem, E | 3 |
| Keskinruzgar, A | 3 |
| Bozdag, Z | 3 |
| Yavuz, GY | 3 |
| Wu, J | 1 |
| Pan, Y | 1 |
| Yu, Y | 1 |
| Yang, Q | 1 |
| Liu, Q | 1 |
| Liu, Y | 1 |
| Zhong, J | 1 |
| Fu, L | 1 |
| Cai, H | 1 |
| Liu, C | 1 |
| Li, G | 1 |
| Lambova, SN | 1 |
| Ivanovska, N | 1 |
| Stoyanova, S | 1 |
| Belenska-Todorova, L | 1 |
| Georgieva, E | 1 |
| Batsalova, T | 1 |
| Moten, D | 1 |
| Apostolova, D | 1 |
| Dzhambazov, B | 1 |
| Scanu, A | 1 |
| Luisetto, R | 1 |
| Pavan, M | 1 |
| Guarise, C | 1 |
| Beninatto, R | 1 |
| Giraudo, C | 1 |
| Galuppini, F | 1 |
| Lazzarin, V | 1 |
| Guzzardo, V | 1 |
| Pennelli, G | 1 |
| Galesso, D | 1 |
| Masiero, S | 1 |
| Wu, H | 1 |
| Xu, T | 1 |
| Chen, Z | 1 |
| Wang, Y | 1 |
| Li, K | 1 |
| Chen, PS | 1 |
| Yao, Z | 1 |
| Su, J | 1 |
| Cheng, C | 1 |
| Wu, X | 1 |
| Zhang, H | 1 |
| Chai, Y | 1 |
| Zhang, X | 1 |
| Hu, Y | 1 |
| Yu, B | 2 |
| Cui, Z | 2 |
| Ziemian, SN | 1 |
| Witkowski, AM | 1 |
| Wright, TM | 1 |
| Otero, M | 1 |
| van der Meulen, MCH | 1 |
| Zhang, N | 2 |
| Tian, F | 3 |
| Gou, Y | 1 |
| Chen, T | 1 |
| Kong, Q | 1 |
| Lv, Q | 1 |
| Li, H | 1 |
| Zhang, L | 3 |
| Panahifar, A | 2 |
| Mahmoudi, M | 1 |
| Doschak, MR | 2 |
| Siebelt, M | 1 |
| Waarsing, JH | 1 |
| Groen, HC | 1 |
| Müller, C | 1 |
| Koelewijn, SJ | 1 |
| de Blois, E | 1 |
| Verhaar, JA | 1 |
| de Jong, M | 1 |
| Weinans, H | 1 |
| Duarte, JH | 1 |
| Xu, C | 1 |
| Li, X | 1 |
| Song, J | 1 |
| Acar, N | 1 |
| Balkarli, H | 1 |
| Soyuncu, Y | 1 |
| Ozbey, O | 1 |
| Celik-Ozenci, C | 1 |
| Korkusuz, P | 1 |
| Ustunel, I | 1 |
| Saag, KG | 1 |
| Hu, H | 2 |
| Li, B | 1 |
| Zhang, Y | 2 |
| Liu, X | 1 |
| Cheng, T | 1 |
| Wang, Z | 1 |
| Giner, M | 1 |
| Rios, MJ | 1 |
| Montoya, MJ | 1 |
| Vázquez, MA | 1 |
| Miranda, C | 1 |
| Pérez-Cano, R | 1 |
| Song, H | 1 |
| Hayami, T | 1 |
| Zhuo, Y | 1 |
| Wesolowski, GA | 1 |
| Pickarski, M | 1 |
| Duong, LT | 1 |
| Maksymowych, WP | 1 |
| Seo, SK | 1 |
| Yang, HI | 1 |
| Lim, KJ | 1 |
| Jeon, YE | 1 |
| Choi, YS | 1 |
| Cho, S | 1 |
| Lee, BS | 1 |
| He, D | 1 |
| Yin, M | 1 |
| Luo, Y | 1 |
| Wei, Q | 1 |
| Zhu, S | 1 |
| Chen, K | 1 |
| Lan, Y | 1 |
| Jiang, R | 1 |
| Hu, J | 1 |
| Ding, M | 1 |
| Danielsen, CC | 1 |
| Hvid, I | 1 |
| Neogi, T | 1 |
| Nevitt, MC | 1 |
| Ensrud, KE | 1 |
| Bauer, D | 1 |
| Felson, DT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Placebo Controlled Trial Testing The Effect of Zoledronic Acid on Hip Osteoarthritis[NCT04303026] | Phase 3 | 70 participants (Anticipated) | Interventional | 2020-03-02 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for alendronate and Arthritis, Degenerative
| Article | Year |
|---|---|
[Research progress of protective effects of alendronate on articular cartilage in osteoarthritis].
Topics: Alendronate; Animals; Anterior Cruciate Ligament; Bone Density Conservation Agents; Bone Remodeling; | 2012 |
2 trials available for alendronate and Arthritis, Degenerative
| Article | Year |
|---|---|
Changes in serum levels of cartilage oligomeric matrix protein after estrogen and alendronate therapy in postmenopausal women.
Topics: Aged; Alendronate; Androstenes; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metab | 2012 |
The effect of alendronate on progression of spinal osteophytes and disc-space narrowing.
Topics: Aged; Alendronate; Bone Density Conservation Agents; Disease Progression; Female; Humans; Interverte | 2008 |
20 other studies available for alendronate and Arthritis, Degenerative
| Article | Year |
|---|---|
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Axial Compressive Loading Attenuates Early Osteoarthritis by Reducing Subchondral Bone Remodeling.
Topics: Alendronate; Animals; Bone Remodeling; Cartilage, Articular; Disease Models, Animal; Inflammation; M | 2023 |
Changes in the Subchondral Bone, Visfatin, and Cartilage Biomarkers after Pharmacological Treatment of Experimental Osteoarthritis with Metformin and Alendronate.
Topics: Alendronate; Animals; Biomarkers; Cartilage, Articular; Disease Models, Animal; Metformin; Mice; Nic | 2023 |
Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus in rats.
Topics: Alendronate; Animals; Cartilage, Articular; Disease Models, Animal; Hyaluronic Acid; Injections, Int | 2023 |
Specific inhibition of FAK signaling attenuates subchondral bone deterioration and articular cartilage degeneration during osteoarthritis pathogenesis.
Topics: Alendronate; Animals; Anterior Cruciate Ligament; Bone and Bones; Bone Remodeling; Cartilage, Articu | 2020 |
Early inhibition of subchondral bone remodeling slows load-induced posttraumatic osteoarthritis development in mice.
Topics: Alendronate; Animals; Bone Remodeling; Cartilage, Articular; Male; Mice; Mice, Inbred C57BL; Osteoar | 2021 |
Protective Effect of Alendronate on Lumbar Facet Degeneration in Ovariectomized Rats.
Topics: Alendronate; Animals; Bone and Bones; Bone Density; Cartilage, Articular; Chondrocytes; Female; Lumb | 2019 |
Synthesis and in vitro evaluation of bone-seeking superparamagnetic iron oxide nanoparticles as contrast agents for imaging bone metabolic activity.
Topics: Adult; Alendronate; Bone and Bones; Bone Density Conservation Agents; Contrast Media; Dextrans; Ferr | 2013 |
Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression.
Topics: Alendronate; Animals; Body Weight; Bone and Bones; Bone Resorption; Cartilage, Articular; Disease Pr | 2014 |
Osteoarthritis: alendronate treatment improves pathology in animal model of OA by blocking osteoclastic bone resorption.
Topics: Alendronate; Animals; Bone Resorption; Disease Progression; Male; Osteoarthritis; Osteoclasts | 2014 |
Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats.
Topics: Acid Phosphatase; Alendronate; Animals; Cartilage, Articular; Collagen Type I; Collagen Type X; Feed | 2015 |
The determination of apoptosis rates on articular cartilages of ovariectomized rats with and without alendronate treatment.
Topics: Alendronate; Animals; Apoptosis; Bone Density Conservation Agents; Cartilage, Articular; Disease Mod | 2016 |
Bisphosphonates for osteoarthritis prevention: "Holy Grail" or not?
Topics: Alendronate; Bone Density Conservation Agents; Diphosphonates; Humans; Osteoarthritis; Radiography; | 2008 |
[In vitro effect of alendronate on chondrocytes and articular cartilage and subchondral bone in rabbit anterior cruciate ligament transection model].
Topics: Alendronate; Animals; Anterior Cruciate Ligament; Cartilage, Articular; Cells, Cultured; Chondrocyte | 2009 |
Alendronate and raloxifene affect the osteoprotegerin/RANKL system in human osteoblast primary cultures from patients with osteoporosis and osteoarthritis.
Topics: Aged; Aged, 80 and over; Alendronate; Bone Density Conservation Agents; Bone Remodeling; Cells, Cult | 2011 |
Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental osteoarthritis.
Topics: Absorptiometry, Photon; Alendronate; Animals; Bone and Bones; Bone Density; Bone Density Conservatio | 2011 |
Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis.
Topics: Alendronate; Animals; Anterior Cruciate Ligament Injuries; Benzamides; Biomarkers; Bone Density Cons | 2012 |
Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation.
Topics: Alendronate; Animals; Arthritis, Experimental; Bone Density Conservation Agents; Drug Evaluation, Pr | 2012 |
Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats.
Topics: Alendronate; Animals; Cartilage, Articular; Female; Immunohistochemistry; Osteoarthritis; Osteoporos | 2013 |
The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis.
Topics: Alendronate; Animals; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Remodelin | 2008 |