alendronate has been researched along with Alveolar Bone Atrophy in 50 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study aims to explore the clinical efficacy of 1% alendronate (ALN) gel as a local drug delivery system in adjunct to scaling and root planing for the treatment of patients with aggressive periodontitis (AgP) compared to placebo gel." | 9.16 | Clinical efficacy of 1% alendronate gel in adjunct to mechanotherapy in the treatment of aggressive periodontitis: a randomized controlled clinical trial. ( Pradeep, AR; Sharma, A, 2012) |
| "To assess sodium alendronate as a local adjunctive therapy for treating experimental periodontitis in male rats treated with chemotherapy." | 8.31 | Sodium alendronate is an effective adjunctive therapy for treating periodontitis in male rats treated with anticancer chemotherapy. ( de Almeida, JM; Ervolino, E; Fiorin, LG; Furquim, EMA; Matheus, HR; Novaes, VCN; Oliveira, FLP; Piovezan, BR, 2023) |
| "The study aimed to investigate the effect of alendronate (ALN) on the inhibition of alveolar bone loss in experimental periodontitis in Wistar rats." | 7.83 | Effect of alendronate on the progression of periodontitis induced by Porphyromonas gingivalis and Fusobacterium nucleatum: a study in rats. ( Crivellaro, V; Deliberador, TM; Giovanini, AF; Romito, GA; Storrer, CLM; Zielak, JC, 2016) |
| "Sodium alendronate preserves alveolar bone resorption and has anti-inflammatory and antibacterial activities in experimental periodontitis." | 7.73 | Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats. ( Brito, GA; Carvalho, CB; Chaves, HV; Menezes, AM; Ribeiro, RA; Rocha, FA, 2005) |
| "Experimental periodontitis was induced by repeated injection of Escherichia coli endotoxin (LPS) and 44 adult male Sprague-Dawley rats were divided into five study groups as follows: LPS, doxycycline + LPS, alendronate + LPS, doxycycline + alendronate + LPS, and saline control." | 7.72 | Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats. ( Atilla, G; Başkesen, A; Berdeli, AH; Buduneli, E; Buduneli, N; Türkoğlu, O; Vardar, S, 2004) |
| "The aim of this study was to evaluate the impact of alendronate (ALD) and estrogen (EST) therapies and their withdrawal on bone loss in experimental periodontitis in ovariectomized rats." | 7.72 | Alendronate may protect against increased periodontitis-related bone loss in estrogen-deficient rats. ( Casati, MZ; de Assis, DR; Duarte, PM; Nociti, FH; Sallum, AW; Sallum, EA, 2004) |
| "This study tested the efficacy of alendronate, a bisphosphate, in reducing alveolar bone loss caused by experimental periodontitis in cynomolgus monkeys." | 7.69 | Histomorphometrical analysis of the effects of the bisphosphonate alendronate on bone loss caused by experimental periodontitis in monkeys. ( Aufdemorte, TB; Brunsvold, M; Chaves, E; Kornman, KS; Quartuccio, H; Rodan, GA; Seedor, JG; Weinreb, M, 1994) |
| "Alendronate sodium is a potent inhibitor of bone resorption which has been effectively used to control osteolysis, and to treat Paget's disease and osteoporosis." | 6.71 | The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial). ( El-Shinnawi, UM; El-Tantawy, SI, 2003) |
| "Periodontitis was induced by ligature in 60 Wistar rats randomized into the following groups: control (Group 1); PDT (Group 2); ALN 0." | 5.48 | Synergistic effect of photodynamic therapy and alendronate on alveolar bone loss in rats with ligature-induced periodontitis. ( Camacho-Alonso, F; Davia-Peña, RS; Martínez-Beneyto, Y; Merino, JJ; Tudela-Mulero, MR; Vilaplana-Vivo, C, 2018) |
| "Alveolar bone loss was evaluated morphometrically under a stereomicroscope." | 5.34 | Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate. ( Atilla, G; Buduneli, E; Buduneli, N; Sorsa, T; Vardar-Sengül, S; Wahlgren, J, 2007) |
| "Considering the emerging role of host-inflammatory response in treatment of periodontitis and the antiresorptive and osteostimulative properties of bisphosphonates, several studies are focusing on the role of alendronate as an addition to non-surgical periodontal therapy." | 5.22 | Added effect of 1% topical alendronate in intra-bony and inter-radicular defects as part of step II periodontal therapy: a systematic review with meta-analysis and trial sequential analysis. ( Arena, C; Caponio, VCA; Lo Muzio, L; Lo Russo, L; Troiano, G; Zhurakivska, K, 2022) |
| " The present study aims to explore the clinical efficacy of 1% alendronate (ALN) gel as a local drug delivery system in adjunct to scaling and root planing for the treatment of patients with aggressive periodontitis (AgP) compared to placebo gel." | 5.16 | Clinical efficacy of 1% alendronate gel in adjunct to mechanotherapy in the treatment of aggressive periodontitis: a randomized controlled clinical trial. ( Pradeep, AR; Sharma, A, 2012) |
| "Alendronate (ALN) increases alveolar bone density with systemic use and, has been found to increase bone formation on local delivery into the periodontal pocket." | 5.16 | Local drug delivery of alendronate gel for the treatment of patients with chronic periodontitis with diabetes mellitus: a double-masked controlled clinical trial. ( Bajaj, P; Kumari, M; Naik, SB; Pradeep, AR; Rao, NS; Sharma, A, 2012) |
| "To assess sodium alendronate as a local adjunctive therapy for treating experimental periodontitis in male rats treated with chemotherapy." | 4.31 | Sodium alendronate is an effective adjunctive therapy for treating periodontitis in male rats treated with anticancer chemotherapy. ( de Almeida, JM; Ervolino, E; Fiorin, LG; Furquim, EMA; Matheus, HR; Novaes, VCN; Oliveira, FLP; Piovezan, BR, 2023) |
| "The study aimed to investigate the effect of alendronate (ALN) on the inhibition of alveolar bone loss in experimental periodontitis in Wistar rats." | 3.83 | Effect of alendronate on the progression of periodontitis induced by Porphyromonas gingivalis and Fusobacterium nucleatum: a study in rats. ( Crivellaro, V; Deliberador, TM; Giovanini, AF; Romito, GA; Storrer, CLM; Zielak, JC, 2016) |
| "Our previous study showed that topical alendronate, an inhibitor of bone resorption, reduces root resorption and ankylosis for 21 d after replantation of rat teeth." | 3.74 | Long-term effects of local pretreatment with alendronate on healing of replanted rat teeth. ( Kawasaki, K; Komatsu, K; Nifuji, A; Oida, S; Shibata, T; Shimada, A; Shimoda, S, 2008) |
| "Sodium alendronate preserves alveolar bone resorption and has anti-inflammatory and antibacterial activities in experimental periodontitis." | 3.73 | Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats. ( Brito, GA; Carvalho, CB; Chaves, HV; Menezes, AM; Ribeiro, RA; Rocha, FA, 2005) |
| "The aim of the present study was to evaluate the effects of systemic administration of low-dose doxycycline and a bisphosphonate, alendronate, on serum levels of interleukin-1beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis in rats." | 3.73 | Systemic low-dose doxycycline and alendronate administration and serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats. ( Atilla, G; Buduneli, E; Buduneli, N; Kardeşler, L; Kinane, DF; Lappin, D; Vardar-Sengül, S, 2005) |
| "Experimental periodontitis was induced by repeated injection of Escherichia coli endotoxin (LPS) and 44 adult male Sprague-Dawley rats were divided into five study groups as follows: LPS, doxycycline + LPS, alendronate + LPS, doxycycline + alendronate + LPS, and saline control." | 3.72 | Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats. ( Atilla, G; Başkesen, A; Berdeli, AH; Buduneli, E; Buduneli, N; Türkoğlu, O; Vardar, S, 2004) |
| "The aim of this study was to evaluate the impact of alendronate (ALD) and estrogen (EST) therapies and their withdrawal on bone loss in experimental periodontitis in ovariectomized rats." | 3.72 | Alendronate may protect against increased periodontitis-related bone loss in estrogen-deficient rats. ( Casati, MZ; de Assis, DR; Duarte, PM; Nociti, FH; Sallum, AW; Sallum, EA, 2004) |
| "This study tested the efficacy of alendronate, a bisphosphate, in reducing alveolar bone loss caused by experimental periodontitis in cynomolgus monkeys." | 3.69 | Histomorphometrical analysis of the effects of the bisphosphonate alendronate on bone loss caused by experimental periodontitis in monkeys. ( Aufdemorte, TB; Brunsvold, M; Chaves, E; Kornman, KS; Quartuccio, H; Rodan, GA; Seedor, JG; Weinreb, M, 1994) |
| "Alendronate is a bisphosphonate frequently used to reduce bone resorption." | 2.73 | The effects of systemic alendronate with or without intraalveolar collagen sponges on postextractive bone resorption: a single masked randomized clinical trial. ( Cei, S; Gabriele, M; Graziani, F; La Ferla, F; Rosini, S, 2008) |
| "Periodontal disease is characterized by periodontal bone loss." | 2.73 | Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis. ( Cizza, G; Genco, R; Jeffcoat, MK; Lombardi, A; Shih, WJ, 2007) |
| "Alendronate sodium is a potent inhibitor of bone resorption which has been effectively used to control osteolysis, and to treat Paget's disease and osteoporosis." | 2.71 | The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial). ( El-Shinnawi, UM; El-Tantawy, SI, 2003) |
| "Alendronate (ALN) is an aminobisphosphonate commonly used for osteoporosis in postmenopausal women." | 2.70 | Clinical and radiological improvement of periodontal disease in patients with type 2 diabetes mellitus treated with alendronate: a randomized, placebo-controlled trial. ( Garay-Sevilla, ME; Malacara, JM; Nava, LE; Rocha, M; Sánchez-Márin, F; Vázquez de la Torre, C, 2001) |
| "Because the severity of alveolar bone loss increases with age, it has long been hypothesized that it may, in part, be related to systemic conditions that also predispose the patient to osteoporosis/osteopenia." | 2.40 | Osteoporosis: a possible modifying factor in oral bone loss. ( Jeffcoat, MK, 1998) |
| "Periodontitis was induced by ligature in 60 Wistar rats randomized into the following groups: control (Group 1); PDT (Group 2); ALN 0." | 1.48 | Synergistic effect of photodynamic therapy and alendronate on alveolar bone loss in rats with ligature-induced periodontitis. ( Camacho-Alonso, F; Davia-Peña, RS; Martínez-Beneyto, Y; Merino, JJ; Tudela-Mulero, MR; Vilaplana-Vivo, C, 2018) |
| "All combined therapies prevented alveolar bone loss when compared with SAL or low doses of monotherapy (ALD or ATV) (p < 0." | 1.40 | Low-dose combination of alendronate and atorvastatin reduces ligature-induced alveolar bone loss in rats. ( Alencar, NM; Benevides, NM; Goes, P; Lima, V; Melo, IM; Ribeiro, RA; Silva, LM, 2014) |
| "Simvastatin has been shown to stimulate new bone growth on rat mandibles, but much of the bone is lost over time." | 1.38 | Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects. ( Killeen, AC; Marx, DB; Narayana, N; Payne, JB; Rakes, PA; Reinhardt, RA; Schmid, MJ; Wang, D; Zhang, Y, 2012) |
| "Periodontitis was induced by ligature around the upper second molar in 36 male Wistar rats (± 200 g)." | 1.38 | Effect of alendronate on bone-specific alkaline phosphatase on periodontal bone loss in rats. ( Dutra, CS; Goes, P; Lima, AP; Lima, V; Melo, IM, 2012) |
| "Alveolar bone loss was evaluated morphometrically under a stereomicroscope." | 1.34 | Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate. ( Atilla, G; Buduneli, E; Buduneli, N; Sorsa, T; Vardar-Sengül, S; Wahlgren, J, 2007) |
| "Alendronate was also effective in reducing bone loss as shown in previous reports." | 1.32 | Combined local application of tetracycline and bisphosphonate reduces alveolar bone resorption in rats. ( Bahar, H; Binderman, I; Herman, A; Yaffe, A, 2003) |
| "The alendronate or saline was administered subcutaneously 1 week prior to surgery, immediately prior to surgery, and 1 week after surgery." | 1.32 | A histopathological investigation on the effect of systemic administration of the bisphosphonate alendronate on resorptive phase following mucoperiosteal flap surgery in the rat mandible. ( Bostanci, H; Günhan, O; Kaynak, D; Meffert, R; Ozkaya, OG, 2003) |
| " Since ISA-13 is well absorbed through mucose tissues, we suggest that ISA-13 efficacy on reducing bone loss should be tested by its application on the mucosal tissue." | 1.31 | The effect of topical delivery of novel bisacylphosphonates in reducing alveolar bone loss in the rat model. ( Binderman, I; Breuer, E; Golomb, G; Yaffe, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (12.00) | 18.2507 |
| 2000's | 25 (50.00) | 29.6817 |
| 2010's | 16 (32.00) | 24.3611 |
| 2020's | 3 (6.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arena, C | 1 |
| Caponio, VCA | 1 |
| Zhurakivska, K | 1 |
| Lo Russo, L | 1 |
| Lo Muzio, L | 1 |
| Troiano, G | 1 |
| Oliveira, FLP | 1 |
| Matheus, HR | 1 |
| Ervolino, E | 1 |
| Novaes, VCN | 1 |
| Piovezan, BR | 1 |
| Furquim, EMA | 1 |
| Fiorin, LG | 1 |
| de Almeida, JM | 1 |
| Al-Assaf, DA | 1 |
| Bede, SY | 1 |
| Camacho-Alonso, F | 1 |
| Davia-Peña, RS | 1 |
| Vilaplana-Vivo, C | 1 |
| Tudela-Mulero, MR | 1 |
| Merino, JJ | 1 |
| Martínez-Beneyto, Y | 1 |
| Carvalho Dutra, B | 1 |
| Oliveira, AMSD | 1 |
| Oliveira, PAD | 1 |
| Miranda Cota, LO | 1 |
| Silveira, JO | 1 |
| Costa, FO | 1 |
| Goes, P | 2 |
| Melo, IM | 2 |
| Silva, LM | 1 |
| Benevides, NM | 1 |
| Alencar, NM | 1 |
| Ribeiro, RA | 2 |
| Lima, V | 2 |
| Salazar, M | 1 |
| Hernandes, L | 1 |
| Ramos, AL | 1 |
| Salazar, Bde O | 1 |
| Micheletti, KR | 1 |
| Paranhos, LR | 1 |
| de Mendonça, MR | 1 |
| Cuoghi, OA | 1 |
| Storrer, CLM | 1 |
| Deliberador, TM | 1 |
| Giovanini, AF | 1 |
| Crivellaro, V | 1 |
| Zielak, JC | 1 |
| Romito, GA | 1 |
| Kanoriya, D | 1 |
| Pradeep, AR | 4 |
| Singhal, S | 1 |
| Garg, V | 1 |
| Guruprasad, CN | 1 |
| Graziani, F | 1 |
| Rosini, S | 1 |
| Cei, S | 1 |
| La Ferla, F | 1 |
| Gabriele, M | 1 |
| Xiong, H | 2 |
| Wei, L | 2 |
| Hu, Y | 1 |
| Zhang, C | 1 |
| Peng, B | 2 |
| Jee, JH | 1 |
| Lee, W | 1 |
| Lee, BD | 1 |
| Ezzat, BA | 1 |
| Sharma, A | 3 |
| Kim, JH | 1 |
| Park, YB | 1 |
| Li, Z | 1 |
| Shim, JS | 1 |
| Moon, HS | 1 |
| Jung, HS | 1 |
| Chung, MK | 1 |
| Rao, NS | 1 |
| Bajaj, P | 1 |
| Naik, SB | 1 |
| Kumari, M | 1 |
| Killeen, AC | 1 |
| Rakes, PA | 1 |
| Schmid, MJ | 2 |
| Zhang, Y | 2 |
| Narayana, N | 2 |
| Marx, DB | 2 |
| Payne, JB | 1 |
| Wang, D | 2 |
| Reinhardt, RA | 2 |
| Dutra, CS | 1 |
| Lima, AP | 1 |
| Price, U | 1 |
| Le, HO | 1 |
| Powell, SE | 1 |
| Tenenbaum, HC | 1 |
| Shelemay, A | 1 |
| Girard, B | 1 |
| Zohar, R | 1 |
| Fritz, PC | 1 |
| El-Shinnawi, UM | 1 |
| El-Tantawy, SI | 1 |
| Yaffe, A | 4 |
| Herman, A | 1 |
| Bahar, H | 1 |
| Binderman, I | 4 |
| Kaynak, D | 2 |
| Meffert, R | 2 |
| Bostanci, H | 1 |
| Günhan, O | 2 |
| Ozkaya, OG | 1 |
| Altundal, H | 1 |
| Güvener, O | 1 |
| Duarte, PM | 2 |
| de Assis, DR | 1 |
| Casati, MZ | 1 |
| Sallum, AW | 2 |
| Sallum, EA | 2 |
| Nociti, FH | 2 |
| Buduneli, E | 3 |
| Vardar, S | 1 |
| Buduneli, N | 3 |
| Berdeli, AH | 1 |
| Türkoğlu, O | 1 |
| Başkesen, A | 1 |
| Atilla, G | 3 |
| Rocha, ML | 1 |
| Malacara, JM | 2 |
| Sánchez-Marin, FJ | 1 |
| Vazquez de la Torre, CJ | 1 |
| Fajardo, ME | 1 |
| de Vasconcelos Gurgel, BC | 1 |
| Filho, GR | 1 |
| Lane, N | 1 |
| Armitage, GC | 1 |
| Loomer, P | 1 |
| Hsieh, S | 1 |
| Majumdar, S | 1 |
| Wang, HY | 1 |
| Jeffcoat, M | 1 |
| Munoz, T | 1 |
| Menezes, AM | 1 |
| Rocha, FA | 1 |
| Chaves, HV | 1 |
| Carvalho, CB | 1 |
| Brito, GA | 1 |
| Vardar-Sengül, S | 2 |
| Kardeşler, L | 1 |
| Lappin, D | 1 |
| Kinane, DF | 1 |
| Wahlgren, J | 1 |
| Sorsa, T | 1 |
| Jeffcoat, MK | 4 |
| Cizza, G | 1 |
| Shih, WJ | 1 |
| Genco, R | 1 |
| Lombardi, A | 1 |
| Spolidorio, LC | 1 |
| Marcantonio, E | 1 |
| Spolidorio, DM | 1 |
| Nassar, CA | 1 |
| Nassar, PO | 1 |
| Marcantonio, RA | 1 |
| Rossa, C | 1 |
| Zhang, X | 1 |
| Wang, L | 1 |
| Giro, G | 1 |
| Gonçalves, D | 1 |
| Sakakura, CE | 1 |
| Pereira, RM | 1 |
| Marcantonio Júnior, E | 1 |
| Orrico, SR | 1 |
| Komatsu, K | 1 |
| Shimada, A | 1 |
| Shibata, T | 1 |
| Shimoda, S | 1 |
| Oida, S | 1 |
| Kawasaki, K | 1 |
| Nifuji, A | 1 |
| Torres, J | 1 |
| Tamimi, F | 1 |
| García, I | 1 |
| Cebrian, JL | 1 |
| López-Cabarcos, E | 1 |
| Lopez, A | 1 |
| Reddy, MS | 2 |
| Weatherford, TW | 1 |
| Smith, CA | 1 |
| West, BD | 1 |
| Jacks, TM | 1 |
| Igarashi, K | 1 |
| Mitani, H | 1 |
| Adachi, H | 1 |
| Shinoda, H | 1 |
| Weinreb, M | 1 |
| Quartuccio, H | 1 |
| Seedor, JG | 1 |
| Aufdemorte, TB | 2 |
| Brunsvold, M | 1 |
| Chaves, E | 1 |
| Kornman, KS | 2 |
| Rodan, GA | 1 |
| Iztkovich, M | 1 |
| Earon, Y | 1 |
| Alt, I | 1 |
| Lilov, R | 1 |
| Günhan, M | 1 |
| Ozkaya, O | 1 |
| Adut, M | 1 |
| Golomb, G | 1 |
| Breuer, E | 1 |
| Lewis, CE | 1 |
| Wang, CY | 1 |
| Redford, M | 1 |
| Rocha, M | 1 |
| Nava, LE | 1 |
| Vázquez de la Torre, C | 1 |
| Sánchez-Márin, F | 1 |
| Garay-Sevilla, ME | 1 |
| Brunsvold, MA | 1 |
| Chaves, ES | 1 |
| Wood, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Alendronate With β - TCP Bone Substitute in Surgical Therapy of Periodontal Intra-osseous Defects: A Randomized, Controlled Clinical Trial.[NCT02795546] | Phase 4 | 32 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial.[NCT03368430] | Phase 4 | 74 participants (Actual) | Interventional | 2016-07-04 | Completed | ||
| Investigation of the Effects of Bisphosphonate on the Gingival Crevicular Fluid Levels of Sclerostin and the DKK-1 in Individuals With Postmenopausal Osteoporosis With Periodontal Changes[NCT04149405] | Phase 4 | 43 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Effect of Periodontal Therapy and Bisphosphonates on Gingival Crevicular Fluid Levels of Nuclear Factor- κb Ligand (RANKL) and Osteoprotegerin in Postmenopausal Osteoporosis: Results of a 12-Month Study[NCT02808988] | Phase 4 | 47 participants (Actual) | Interventional | 2013-10-31 | Completed | ||
| The Effect of Orally Administered Bisphosphonates in the Treatment of Osteoporosis on the Alveolar Bone Using Panoramic and Cone-Beam CT Imaging: A Case-control Study[NCT02115490] | 60 participants (Actual) | Observational | 2014-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
levels of dickkopf-related protein-1 in 12th month (NCT04149405)
Timeframe: 12 months
| Intervention | ng/ml (Mean) |
|---|---|
| Group A | 3440.67 |
| Group B | 3203.802 |
| Group C | 2490.553 |
| Group D | 4269.39 |
levels of dickkopf-related protein-1 in 6th month (NCT04149405)
Timeframe: 6 months
| Intervention | ng/ml (Mean) |
|---|---|
| Group A | 3358.265 |
| Group B | 1963.185 |
| Group C | 3263.665 |
| Group D | 4269.39 |
levels of sclerostin in 12th month (NCT04149405)
Timeframe: 12 month
| Intervention | ng/ml (Mean) |
|---|---|
| Group A | 1702.265 |
| Group B | 1347.330 |
| Group C | 1114.988 |
| Group D | 2131.87 |
levels of sclerostin in 6th month (NCT04149405)
Timeframe: 6 months
| Intervention | ng/ml (Mean) |
|---|---|
| Group A | 1389.177 |
| Group B | 1085.405 |
| Group C | 1596.585 |
| Group D | 2131.87 |
4 reviews available for alendronate and Alveolar Bone Atrophy
| Article | Year |
|---|---|
Added effect of 1% topical alendronate in intra-bony and inter-radicular defects as part of step II periodontal therapy: a systematic review with meta-analysis and trial sequential analysis.
Topics: Alendronate; Alveolar Bone Loss; Diphosphonates; Humans; Periodontal Attachment Loss; Periodontitis | 2022 |
Bisphosphonates and periodontics: potential applications for regulation of bone mass in the periodontium and other therapeutic/diagnostic uses.
Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density; Bone Regeneration; Diphosphonates; Etidronic | 2002 |
Osteoporosis: a possible modifying factor in oral bone loss.
Topics: Alendronate; Alveolar Bone Loss; Bone Density; Estrogen Replacement Therapy; Female; Humans; Male; M | 1998 |
Post-menopausal bone loss and its relationship to oral bone loss.
Topics: Absorptiometry, Photon; Alendronate; Alveolar Bone Loss; Bone Density; Calcium; Estrogen Replacement | 2000 |
12 trials available for alendronate and Alveolar Bone Atrophy
| Article | Year |
|---|---|
The Effects of Local Alendronate With or Without Recombinant Human Bone Morphogenetic Protein 2 on Dental Implant Stability and Marginal Bone Level: A Randomized Controlled Study.
Topics: Alendronate; Alveolar Bone Loss; Bone Morphogenetic Protein 2; Dental Implantation, Endosseous; Dent | 2022 |
Effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: A 6-month randomized controlled clinical trial.
Topics: Alendronate; Alveolar Bone Loss; Follow-Up Studies; Guided Tissue Regeneration, Periodontal; Humans; | 2019 |
Synergistic Approach Using Platelet-Rich Fibrin and 1% Alendronate for Intrabony Defect Treatment in Chronic Periodontitis: A Randomized Clinical Trial.
Topics: Alendronate; Alveolar Bone Loss; Bone Density Conservation Agents; Chronic Periodontitis; Humans; Pe | 2016 |
The effects of systemic alendronate with or without intraalveolar collagen sponges on postextractive bone resorption: a single masked randomized clinical trial.
Topics: Absorbable Implants; Adult; Alendronate; Alveolar Bone Loss; Alveolar Process; Biocompatible Materia | 2008 |
Clinical efficacy of 1% alendronate gel as a local drug delivery system in the treatment of chronic periodontitis: a randomized, controlled clinical trial.
Topics: Adult; Alendronate; Alveolar Bone Loss; Bone Density Conservation Agents; Bone Regeneration; Chronic | 2012 |
Clinical efficacy of 1% alendronate gel in adjunct to mechanotherapy in the treatment of aggressive periodontitis: a randomized controlled clinical trial.
Topics: Adult; Aggressive Periodontitis; Alendronate; Alveolar Bone Loss; Bone Density Conservation Agents; | 2012 |
Local drug delivery of alendronate gel for the treatment of patients with chronic periodontitis with diabetes mellitus: a double-masked controlled clinical trial.
Topics: Adult; Alendronate; Alveolar Bone Loss; Bone Density Conservation Agents; Bone Regeneration; Chi-Squ | 2012 |
The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial).
Topics: Absorptiometry, Photon; Adult; Alendronate; Alveolar Bone Loss; Alveolar Process; Bone Density; Dent | 2003 |
Effect of alendronate on periodontal disease in postmenopausal women: a randomized placebo-controlled trial.
Topics: Administration, Oral; Aged; Alendronate; Alveolar Bone Loss; Bone Density; Double-Blind Method; Fema | 2004 |
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho | 2005 |
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho | 2005 |
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho | 2005 |
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho | 2005 |
Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis.
Topics: Adult; Aged; Alendronate; Alveolar Bone Loss; Alveolar Process; Analysis of Variance; Bone Density; | 2007 |
Clinical and radiological improvement of periodontal disease in patients with type 2 diabetes mellitus treated with alendronate: a randomized, placebo-controlled trial.
Topics: Alendronate; Alveolar Bone Loss; Alveolar Process; Biomarkers; Bone Resorption; Case-Control Studies | 2001 |
34 other studies available for alendronate and Alveolar Bone Atrophy
| Article | Year |
|---|---|
Sodium alendronate is an effective adjunctive therapy for treating periodontitis in male rats treated with anticancer chemotherapy.
Topics: Alendronate; Alveolar Bone Loss; Animals; Dental Scaling; Fluorouracil; Male; Osteocalcin; Periodont | 2023 |
Synergistic effect of photodynamic therapy and alendronate on alveolar bone loss in rats with ligature-induced periodontitis.
Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density; Disease Models, Animal; Drug Combinations; D | 2018 |
Low-dose combination of alendronate and atorvastatin reduces ligature-induced alveolar bone loss in rats.
Topics: Acid Phosphatase; Alanine Transaminase; Alendronate; Alkaline Phosphatase; Alveolar Bone Loss; Anima | 2014 |
Effect of alendronate sodium on tooth movement in ovariectomized rats.
Topics: Alendronate; Alveolar Bone Loss; Animals; Female; Osteoclasts; Ovariectomy; Rats; Rats, Wistar; Toot | 2015 |
Effect of alendronate on the progression of periodontitis induced by Porphyromonas gingivalis and Fusobacterium nucleatum: a study in rats.
Topics: Alendronate; Alveolar Bone Loss; Animals; Disease Progression; Fusobacterium nucleatum; Male; Period | 2016 |
Effect of alendronate on alveolar bone resorption and angiogenesis in rats with experimental periapical lesions.
Topics: Acid Phosphatase; Alendronate; Alveolar Bone Loss; Alveolar Process; Animals; Bone Density Conservat | 2010 |
The influence of alendronate on the healing of extraction sockets of ovariectomized rats assessed by in vivo micro-computed tomography.
Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density Conservation Agents; Ovariectomy; Random Allo | 2010 |
Validity of prevention of glucocorticoid-induced alveolar bone loss in rat by either calcitonin or alendronate administration.
Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density; Bone Density Conservation Agents; Calcitonin | 2010 |
Effect of alendronate on healing of extraction sockets and healing around implants.
Topics: Acid Phosphatase; Alendronate; Alveolar Bone Loss; Animals; Azo Compounds; Biomarkers; Bone Density | 2011 |
Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects.
Topics: Administration, Topical; Alendronate; Alveolar Bone Loss; Animals; Bone Density Conservation Agents; | 2012 |
Effect of alendronate on bone-specific alkaline phosphatase on periodontal bone loss in rats.
Topics: Alendronate; Alkaline Phosphatase; Alveolar Bone Loss; Alveolar Process; Analysis of Variance; Anima | 2012 |
Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss.
Topics: Alendronate; Alveolar Bone Loss; Animals; beta-Cyclodextrins; Bone Density Conservation Agents; Drug | 2013 |
Combined local application of tetracycline and bisphosphonate reduces alveolar bone resorption in rats.
Topics: Administration, Topical; Alendronate; Alveolar Bone Loss; Alveolar Process; Animals; Anti-Bacterial | 2003 |
A histopathological investigation on the effect of systemic administration of the bisphosphonate alendronate on resorptive phase following mucoperiosteal flap surgery in the rat mandible.
Topics: Alendronate; Alveolar Bone Loss; Alveolar Process; Animals; Bone Resorption; Chi-Square Distribution | 2003 |
The effect of alendronate on resorption of the alveolar bone following tooth extraction.
Topics: Alendronate; Alkaline Phosphatase; Alveolar Bone Loss; Alveolar Process; Animals; Bone Matrix; Calci | 2004 |
Alendronate may protect against increased periodontitis-related bone loss in estrogen-deficient rats.
Topics: Alendronate; Alkaline Phosphatase; Alveolar Bone Loss; Alveolar Process; Animals; Dental Plaque Inde | 2004 |
Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats.
Topics: Alendronate; Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Dinoprost; Dinoprostone; Doxycyclin | 2004 |
Alendronate therapy may be effective in the prevention of bone loss around titanium implants inserted in estrogen-deficient rats.
Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density; Dental Alloys; Dental Implantation, Endosseo | 2005 |
Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats.
Topics: Alendronate; Alveolar Bone Loss; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bone Dens | 2005 |
Systemic low-dose doxycycline and alendronate administration and serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats.
Topics: Alendronate; Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Bone Density Conservation Agents; C | 2005 |
Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate.
Topics: Alendronate; Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Bone Density Conservation Agents; C | 2007 |
Alendronate therapy in cyclosporine-induced alveolar bone loss in rats.
Topics: Acid Phosphatase; Alendronate; Alkaline Phosphatase; Alveolar Bone Loss; Alveolar Process; Animals; | 2007 |
Effect of an estrogen-deficient state and alendronate therapy on bone loss resulting from experimental periapical lesions in rats.
Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density Conservation Agents; Estrogens; Female; Injec | 2007 |
Influence of estrogen deficiency and its treatment with alendronate and estrogen on bone density around osseointegrated implants: radiographic study in female rats.
Topics: Absorptiometry, Photon; Alendronate; Alveolar Bone Loss; Analysis of Variance; Animals; Bone Density | 2008 |
Long-term effects of local pretreatment with alendronate on healing of replanted rat teeth.
Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density Conservation Agents; Dental Pulp Calcificatio | 2008 |
Management of atrophic maxilla in severe osteoporosis treated with bisphosphonates: a case report.
Topics: Alendronate; Alveolar Bone Loss; Bone Density; Bone Density Conservation Agents; Bone Regeneration; | 2008 |
Alendronate treatment of naturally-occurring periodontitis in beagle dogs.
Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Animals; Diphosphonates; Disease Models, Anim | 1995 |
Anchorage and retentive effects of a bisphosphonate (AHBuBP) on tooth movements in rats.
Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Animals; Dental Stress Analysis; Diphosphonat | 1994 |
Histomorphometrical analysis of the effects of the bisphosphonate alendronate on bone loss caused by experimental periodontitis in monkeys.
Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density; Diphosphonates; Macaca fascicularis; Mandibu | 1994 |
Local delivery of an amino bisphosphonate prevents the resorptive phase of alveolar bone following mucoperiosteal flap surgery in rats.
Topics: Administration, Topical; Alendronate; Alveolar Bone Loss; Alveolar Process; Animals; Bone Diseases; | 1997 |
A histopathological investigation on the effects of the bisphosphonate alendronate on resorptive phase following mucoperiosteal flap surgery in the mandible of rats.
Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Remodeling; Male; Matched-Pair Analysis; Osteoblasts; | 2000 |
Effectiveness of local delivery of alendronate in reducing alveolar bone loss following periodontal surgery in rats.
Topics: Administration, Buccal; Administration, Oral; Administration, Topical; Alendronate; Alveolar Bone Lo | 2000 |
The effect of topical delivery of novel bisacylphosphonates in reducing alveolar bone loss in the rat model.
Topics: Administration, Topical; Alendronate; Alveolar Bone Loss; Alveolar Process; Animals; Chi-Square Dist | 2000 |
Effects of a bisphosphonate on experimental periodontitis in monkeys.
Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density; Dental Plaque Index; Diphosphonates; Macaca | 1992 |