alendronate has been researched along with ACL Injuries in 2 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the disease modifying effects of cathepsin K (CatK) inhibitor L-006235 compared to alendronate (ALN) in two preclinical models of osteoarthritis (OA)." | 3.78 | Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. ( Duong, LT; Hayami, T; Pickarski, M; Wesolowski, GA; Zhuo, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khorasani, MS | 1 |
| Diko, S | 1 |
| Hsia, AW | 1 |
| Anderson, MJ | 1 |
| Genetos, DC | 1 |
| Haudenschild, DR | 1 |
| Christiansen, BA | 1 |
| Hayami, T | 1 |
| Zhuo, Y | 1 |
| Wesolowski, GA | 1 |
| Pickarski, M | 1 |
| Duong, LT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Placebo Controlled Trial Testing The Effect of Zoledronic Acid on Hip Osteoarthritis[NCT04303026] | Phase 3 | 70 participants (Anticipated) | Interventional | 2020-03-02 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for alendronate and ACL Injuries
| Article | Year |
|---|---|
Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice.
Topics: Alendronate; Animals; Anterior Cruciate Ligament Injuries; Bone Density Conservation Agents; Bone Re | 2015 |
Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis.
Topics: Alendronate; Animals; Anterior Cruciate Ligament Injuries; Benzamides; Biomarkers; Bone Density Cons | 2012 |