aldrin and Seizures

Magnesium chloride (MgCl2) has been proposed for the treatment of seizures of different etiologies. The present study investigated the effect of MgCl2 on aldrin-induced seizures. Initially, 50 male rats received 60 mg aldrin/kg po and the effects were classified as muscular twitches, clonic convulsions or tonic-clonic convulsions. Another group of 40 rats dosed with 60 mg aldrin/kg po received 0, 4, 8, or 12 mg MgCl2/kg i.m. The percentage of tonic-clonic convulsant rats that resulted from MgCl2 treatment were 90% at 0 mg/kg, 50% at 4 mg/kg, 40% at 8 mg/kg and 20% at 12 mg MgCl2/kg. The percentage of survivors in the group receiving 12 mg MgCl2/kg was 80% while the control group had 20% survival. The clonic convulsions were not modified by MgCl2 treatment. Blood and brain concentrations of aldrin and dieldrin (metabolite of aldrin) did not differ among groups. The MgCl2 administration decreased the neuroexcitability induced by aldrin and increased survivability.

Topics: Aldrin; Animals; Behavior, Animal; Drug Interactions; Insecticides; Magnesium Chloride; Male; Rats; Rats, Wistar; Seizures

Sixteen patients acutely poisoned with aldrin were examined to evaluate a possible correlation between serum aldrin and dieldrin levels and clinical complaints. The patients were classified as having mild (N = 8), moderate (N = 5) or severe (N = 3) poisoning according to clinical symptoms. Concentrations of less than 20 micrograms/l were usually associated with mild poisoning, which involved complaints such as nausea, vomiting and epigastric pain, whereas concentrations of 100 to 200 micrograms/l were considered to represent moderate intoxication and were associated with nausea, vomiting, epigastric pain, headache, dizziness, and convulsions. Severe or fatal cases were associated with levels above 700 micrograms/l. Taken together, these results suggest that serum aldrin and dieldrin levels can be used as indicators of clinical prognosis after acute poisoning with these insecticides and that convulsions could suddenly occur even in the absence of prodromal signs or symptoms.

Topics: Acute Disease; Adolescent; Adult; Aldrin; Child, Preschool; Chromatography, Gas; Dieldrin; Female; Humans; Infant; Male; Prognosis; Seizures

The effects of long-term administration of sub-convulsive doses of aldrin, an organochlorinated pesticide, on seizure susceptibility of rats were studied. Results show that treatment with the pesticide made the rats more susceptible to sound-induced seizures; an increment in post-seizure depression time after maximal electroshock administration was also observed in aldrin-treated animals. Aldrin administration displaced the control dose-response curves constructed for amphetamine and pentylenetetrazol to the left and right, respectively; no differences were detected between control and aldrin-treated rats for strychnine, picrotoxin or 3-mercaptopropionic acid. The results, discussed in the light of the effects of aldrin on biogenic amines or on the electrophysiology of neurones suggested an involvement of both noradrenergic and alteration excitability of the CNS with the observed increments on seizure susceptibility.

Topics: Acoustic Stimulation; Aldrin; Animals; Convulsants; Dose-Response Relationship, Drug; Electroshock; Male; Rats; Rats, Inbred Strains; Seizures

Topics: Aldrin; Animals; Cat Diseases; Cats; Dieldrin; Female; Male; Pesticide Residues; Seizures; Soil; Soil Pollutants

Topics: Adolescent; Adult; Aldrin; Child; Child, Preschool; Chronic Disease; Electroencephalography; Female; Hexachlorocyclohexane; Humans; Infant; Male; Middle Aged; Myoclonus; Poisoning; Seizures

Topics: Aldrin; Animals; Avoidance Learning; Body Weight; Conditioning, Psychological; Electroshock; Female; Hydrocarbons, Halogenated; Insecticides; Male; Maternal-Fetal Exchange; Mice; Pregnancy; Seizures

Chemical, pharmacologic and toxicologic properties of the chlorinated hydrocarbon and organic phosphate insecticides have been reviewed. The chlorinated group present problems if there is either acute or chronic exposure, whereas the problems associated with the organic phosphates develop only in event of acute exposure. Chlorinated hydrocarbon insecticides accumulate in body fat depots and cause both liver and kidney damage while being metabolized and excreted. Organic phosphates destroy cholinesterase and produce effects related to overstimulation of the cholinergic branch of the autonomic nervous system. Barbiturates control the convulsions produced by the chlorinated hydrocarbon insecticides. Atropine blocks most of the effects of the organic phosphate insecticides. These compounds may be grouped in the following order of decreasing toxicity: TEPP, HETP, parathion, OMPA, ENP, aldrin, chlorophenothane, toxaphene, gamma benzene hexachloride, malathon and chlordane.

Topics: Aldrin; Atropine; Autonomic Nervous System; Chlordan; Cholinesterases; DDT; Hexachlorocyclohexane; Insecticides; Organophosphorus Compounds; Parathion; Poisoning; Seizures; Toxaphene