aldrin and Poisoning

A sudden onset of bizarre neurologic dysfunction was found in 8 of 90 mixed-breed feeder calves. Seven other calves were dead, and 3 more died during the next week. A diagnosis of organochlorine toxicosis was made when rumen and abomasal contents from 1 of the calves revealed 22.4 and 20.6 micrograms of aldrin/g of ingesta, respectively. Complete feeds retrieved from self-feeders contained 54 and 528 micrograms of aldrin/g of feed. The initial concentration range in fat from 40 live calves was 6.01 to 42.44 micrograms of dieldrin/g of fat. Additional fat samples were analyzed to verify residue compliance until the entire herd was clear of residue 18 months after removal of the contaminated ration. The range of apparent half-lives for dieldrin in body fat of heifers and steers was 69 to 231 and 53 to 116 days, respectively. These findings demonstrate the considerable variability in apparent half-life of dieldrin in field cases. In cases of dieldrin-contaminated livestock, veterinarians and regulatory personnel must accurately determine the necessary slaughter withholding times so that informed economic decisions are made in the best interest of the producer while enhancing the probability of a safe food supply. Excretion rates of dieldrin from field-contaminated cattle may not be consistent with results obtained under experimental conditions.

Topics: Adipose Tissue; Aldrin; Animal Feed; Animals; Cattle; Cattle Diseases; Chromatography, Gas; Dieldrin; Drug Residues; Female; Food Contamination; Gas Chromatography-Mass Spectrometry; Half-Life; Male; Poisoning

Topics: Adolescent; Adult; Aldrin; Child; Child, Preschool; Chronic Disease; Electroencephalography; Female; Hexachlorocyclohexane; Humans; Infant; Male; Middle Aged; Myoclonus; Poisoning; Seizures

Topics: Aldrin; Animals; Brain Chemistry; Carnivora; Chromatography, Thin Layer; Denmark; Digestive System; Female; Kidney; Liver; Male; Parathion; Poisoning; Pyrimidines; Rodenticides; Spectrophotometry, Atomic; Streptococcal Infections; Sulfates; Thallium

Topics: Adolescent; Agricultural Workers' Diseases; Aldrin; Cerebrospinal Fluid Proteins; Clinical Laboratory Techniques; DDT; Dichlorodiphenyldichloroethane; Endrin; Insecticides; Laboratories; Neuritis; Poisoning; Polyneuropathies; Toxicology

Topics: Aldrin; Chemical and Drug Induced Liver Injury; Dieldrin; Dogs; Hepatitis; Hepatitis A; Insecticides; Kidney Diseases; Pathology; Poisoning; Rats; Research; Statistics as Topic; Toxicology

Chemical, pharmacologic and toxicologic properties of the chlorinated hydrocarbon and organic phosphate insecticides have been reviewed. The chlorinated group present problems if there is either acute or chronic exposure, whereas the problems associated with the organic phosphates develop only in event of acute exposure. Chlorinated hydrocarbon insecticides accumulate in body fat depots and cause both liver and kidney damage while being metabolized and excreted. Organic phosphates destroy cholinesterase and produce effects related to overstimulation of the cholinergic branch of the autonomic nervous system. Barbiturates control the convulsions produced by the chlorinated hydrocarbon insecticides. Atropine blocks most of the effects of the organic phosphate insecticides. These compounds may be grouped in the following order of decreasing toxicity: TEPP, HETP, parathion, OMPA, ENP, aldrin, chlorophenothane, toxaphene, gamma benzene hexachloride, malathon and chlordane.

Topics: Aldrin; Atropine; Autonomic Nervous System; Chlordan; Cholinesterases; DDT; Hexachlorocyclohexane; Insecticides; Organophosphorus Compounds; Parathion; Poisoning; Seizures; Toxaphene

Topics: Aldrin; Autonomic Nervous System; Dieldrin; Insecticides; Poisoning

Topics: Aldrin; Insecticides; Poisoning