aldosterone has been researched along with Vascular Calcification in 18 studies
Vascular Calcification: Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These observations support a putative benefit of spironolactone treatment in CKD-associated vascular calcification." | 9.41 | Protective effects of spironolactone on vascular calcification in chronic kidney disease. ( Alesutan, I; Auer, T; Buehling, SS; Degenhart, G; Feger, M; Grebe, S; Hammer, F; Hauser, T; Krane, V; Lang, F; Malzahn, U; Masyout, J; Pasch, A; Tuffaha, R; Voelkl, J; Wanner, C, 2021) |
| "Vascular calcification is frequently found already in early stages of chronic kidney disease (CKD) patients and is associated with high cardiovascular risk." | 6.50 | Impact of aldosterone on osteoinductive signaling and vascular calcification. ( Alesutan, I; Lang, F; Ritz, E; Voelkl, J, 2014) |
| "Primary aldosteronism (PA) is associated with a higher prevalence of abdominal aortic calcification (AAC)." | 5.56 | Abdominal aortic calcification is more severe in unilateral primary aldosteronism patients and is associated with elevated aldosterone and parathyroid hormone levels. ( Li, N; Luo, Q; Tuersun, T; Wang, G; Wang, M; Wu, T; Yue, N; Zhang, D; Zhang, Z; Zhou, K, 2020) |
| "These observations support a putative benefit of spironolactone treatment in CKD-associated vascular calcification." | 5.41 | Protective effects of spironolactone on vascular calcification in chronic kidney disease. ( Alesutan, I; Auer, T; Buehling, SS; Degenhart, G; Feger, M; Grebe, S; Hammer, F; Hauser, T; Krane, V; Lang, F; Malzahn, U; Masyout, J; Pasch, A; Tuffaha, R; Voelkl, J; Wanner, C, 2021) |
| "Aldosterone (Aldo) is an important active hormone in the renin-angiotensin-aldosterone system and plays a vital role in the development of hypertension, heart failure and other cardiovascular diseases." | 5.38 | Endogenous aldosterone is involved in vascular calcification in rat. ( Cai, Y; Jia, LX; Qi, YF; Tang, CS; Wang, X; Wu, SY; Xiao, CS; Yu, YR, 2012) |
| "Vascular calcification is frequently found already in early stages of chronic kidney disease (CKD) patients and is associated with high cardiovascular risk." | 2.50 | Impact of aldosterone on osteoinductive signaling and vascular calcification. ( Alesutan, I; Lang, F; Ritz, E; Voelkl, J, 2014) |
| "Primary aldosteronism (PA) is associated with a higher prevalence of abdominal aortic calcification (AAC)." | 1.56 | Abdominal aortic calcification is more severe in unilateral primary aldosteronism patients and is associated with elevated aldosterone and parathyroid hormone levels. ( Li, N; Luo, Q; Tuersun, T; Wang, G; Wang, M; Wu, T; Yue, N; Zhang, D; Zhang, Z; Zhou, K, 2020) |
| "Vascular calcification is driven by aldosterone-sensitive osteogenic transformation of vascular smooth muscle cells (VSMCs)." | 1.46 | Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells. ( Alesutan, I; Borst, O; Castor, T; Feger, M; Gawaz, M; Kratschmar, DV; Kuro-O, M; Lang, F; Leibrock, C; Mia, S; Odermatt, A; Pieske, B; Pilz, S; Sacherer, M; Tomaschitz, A; Viereck, R; Voelkl, J; Wagner, CA, 2017) |
| "Aldosterone and SATB2 were found to be markedly upregulated during VSMC calcification, whereas miR-34b/c expression was downregulated." | 1.43 | MicroRNA-34b/c inhibits aldosterone-induced vascular smooth muscle cell calcification via a SATB2/Runx2 pathway. ( Cong, G; Hao, J; Hao, L; Ren, L; Zhang, L, 2016) |
| "Aldosterone (Aldo) is an important active hormone in the renin-angiotensin-aldosterone system and plays a vital role in the development of hypertension, heart failure and other cardiovascular diseases." | 1.38 | Endogenous aldosterone is involved in vascular calcification in rat. ( Cai, Y; Jia, LX; Qi, YF; Tang, CS; Wang, X; Wu, SY; Xiao, CS; Yu, YR, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (61.11) | 24.3611 |
| 2020's | 7 (38.89) | 2.80 |
| Authors | Studies |
|---|---|
| Hammer, F | 1 |
| Buehling, SS | 1 |
| Masyout, J | 1 |
| Malzahn, U | 1 |
| Hauser, T | 1 |
| Auer, T | 1 |
| Grebe, S | 1 |
| Feger, M | 3 |
| Tuffaha, R | 1 |
| Degenhart, G | 1 |
| Lang, F | 6 |
| Pasch, A | 1 |
| Alesutan, I | 5 |
| Wanner, C | 1 |
| Krane, V | 1 |
| Voelkl, J | 6 |
| Zhang, X | 1 |
| Zhou, X | 1 |
| Huang, Z | 1 |
| Fan, X | 1 |
| Tan, X | 1 |
| Lu, C | 1 |
| Yang, J | 1 |
| Chang, X | 1 |
| Hao, J | 2 |
| Wang, X | 2 |
| Liu, J | 1 |
| Ni, J | 1 |
| Hao, L | 2 |
| Li, XZ | 1 |
| Xiong, ZC | 1 |
| Zhang, SL | 1 |
| Hao, QY | 1 |
| Liu, ZY | 2 |
| Zhang, HF | 1 |
| Wang, JF | 2 |
| Gao, JW | 2 |
| Liu, PM | 2 |
| Unkart, JT | 1 |
| Allison, MA | 1 |
| Abdelmalek, JA | 1 |
| Jenny, NS | 1 |
| McClelland, RL | 1 |
| Budoff, M | 1 |
| Ix, JH | 1 |
| Rifkin, DE | 1 |
| Tuersun, T | 1 |
| Luo, Q | 1 |
| Zhang, Z | 1 |
| Wang, G | 1 |
| Zhang, D | 1 |
| Wang, M | 1 |
| Wu, T | 1 |
| Zhou, K | 1 |
| Yue, N | 1 |
| Li, N | 1 |
| He, WB | 1 |
| Xie, CM | 1 |
| Gao, M | 1 |
| Feng, LY | 1 |
| Huang, H | 2 |
| Kratschmar, DV | 1 |
| Castor, T | 1 |
| Mia, S | 2 |
| Sacherer, M | 1 |
| Viereck, R | 1 |
| Borst, O | 1 |
| Leibrock, C | 1 |
| Gawaz, M | 1 |
| Kuro-O, M | 3 |
| Pilz, S | 1 |
| Tomaschitz, A | 1 |
| Odermatt, A | 1 |
| Pieske, B | 1 |
| Wagner, CA | 1 |
| Zhang, S | 1 |
| Wang, N | 1 |
| Chen, L | 1 |
| Zhang, P | 1 |
| Shen, L | 1 |
| Huang, S | 1 |
| Zhang, C | 1 |
| Deng, B | 1 |
| Ritz, E | 2 |
| Leibrock, CB | 2 |
| Kohlhofer, U | 1 |
| Quintanilla-Martinez, L | 2 |
| Gao, J | 1 |
| Zhang, K | 1 |
| Chen, J | 1 |
| Wang, MH | 1 |
| Wang, J | 1 |
| Liu, P | 1 |
| Gong, YC | 1 |
| He, Y | 1 |
| Wang, H | 1 |
| Niu, WQ | 1 |
| Ji, KD | 1 |
| Li, H | 1 |
| Zhang, L | 1 |
| Cong, G | 1 |
| Ren, L | 1 |
| Yan, TK | 1 |
| Jia, JY | 1 |
| Lin, S | 1 |
| Wu, SY | 1 |
| Yu, YR | 1 |
| Cai, Y | 1 |
| Jia, LX | 1 |
| Xiao, CS | 1 |
| Tang, CS | 1 |
| Qi, YF | 1 |
| Kuhn, V | 1 |
| Ahmed, MS | 1 |
| Rosenblatt, KP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Spironolactone on the Progression of Coronary Calcification in Peritoneal Dialysis Patients[NCT03314493] | Phase 3 | 33 participants (Actual) | Interventional | 2014-11-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for aldosterone and Vascular Calcification
| Article | Year |
|---|---|
Vascular calcification--is aldosterone a culprit?
Topics: Aldosterone; Animals; Humans; Hyperphosphatemia; Mice; Renal Insufficiency, Chronic; Vascular Calcif | 2013 |
Impact of aldosterone on osteoinductive signaling and vascular calcification.
Topics: Aldosterone; Animals; Cardiovascular Diseases; Humans; Hyperphosphatemia; Mice; Mineralocorticoid Re | 2014 |
Roles of aldosterone in vascular calcification: An update.
Topics: Aldosterone; Animals; Humans; Vascular Calcification | 2016 |
1 trial available for aldosterone and Vascular Calcification
| Article | Year |
|---|---|
Protective effects of spironolactone on vascular calcification in chronic kidney disease.
Topics: Aldosterone; Alkaline Phosphatase; Animals; Aorta; Biomarkers; Cholecalciferol; Core Binding Factor | 2021 |
14 other studies available for aldosterone and Vascular Calcification
| Article | Year |
|---|---|
Aldosterone is a possible new stimulating factor for promoting vascular calcification.
Topics: Aldosterone; Animals; Aorta; Rats; Renin-Angiotensin System; Spironolactone; Vascular Calcification | 2021 |
The Role of AIF-1 in the Aldosterone-Induced Vascular Calcification Related to Chronic Kidney Disease: Evidence From Mice Model and Cell Co-Culture Model.
Topics: Aldosterone; Animals; Coculture Techniques; Disease Models, Animal; Endothelial Cells; Mice; Mice, K | 2022 |
Upregulated LncRNA H19 Sponges MiR-106a-5p and Contributes to Aldosterone-Induced Vascular Calcification via Activating the Runx2-Dependent Pathway.
Topics: Aldosterone; Animals; Core Binding Factor Alpha 1 Subunit; Humans; MicroRNAs; Myocytes, Smooth Muscl | 2023 |
Relation of Plasma Renin Activity to Subclinical Peripheral and Coronary Artery Disease (from the Multiethnic Study of Atherosclerosis).
Topics: Aldosterone; Ankle Brachial Index; Atherosclerosis; Biomarkers; Coronary Artery Disease; Female; Hum | 2020 |
Abdominal aortic calcification is more severe in unilateral primary aldosteronism patients and is associated with elevated aldosterone and parathyroid hormone levels.
Topics: Adult; Aldosterone; Aortic Diseases; China; Cross-Sectional Studies; Female; Humans; Hyperaldosteron | 2020 |
Aldosterone enhances high phosphate-induced vascular calcification through inhibition of AMPK-mediated autophagy.
Topics: Aldosterone; AMP-Activated Protein Kinases; Animals; Autophagy; Biomarkers; Calcium; Cell Differenti | 2020 |
Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells.
Topics: Adrenalectomy; Aldosterone; Aorta; Coronary Vessels; Cytochrome P-450 CYP11B2; Gene Expression Regul | 2017 |
Serum Aldosterone Is Associated with Cerebral Artery Atherosclerosis and Calcification.
Topics: Aged; Aldosterone; Biomarkers; Cerebral Angiography; Cerebral Arteries; China; Computed Tomography A | 2019 |
Bicarbonate-sensitive calcification and lifespan of klotho-deficient mice.
Topics: Acidosis; Aldosterone; Animals; Calcinosis; Calcitriol; Calcium; Genotype; Glucuronidase; Hyperaldos | 2016 |
Silencing of osterix expression by siRNA inhibits aldosterone‑induced calcification of vascular smooth muscle cells in mice.
Topics: Aldosterone; Animals; Calcium; Cells, Cultured; Gene Expression; Gene Silencing; Integrin-Binding Si | 2016 |
MicroRNA-34b/c inhibits aldosterone-induced vascular smooth muscle cell calcification via a SATB2/Runx2 pathway.
Topics: 3' Untranslated Regions; Aldosterone; Animals; Aorta; Base Sequence; Core Binding Factor Alpha 1 Sub | 2016 |
[The role of aldosterone in uremic vascular calcification in patient with end-stage renal disease].
Topics: Aldosterone; Humans; Kidney Failure, Chronic; Uremia; Vascular Calcification | 2010 |
Endogenous aldosterone is involved in vascular calcification in rat.
Topics: Aldosterone; Alkaline Phosphatase; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals | 2012 |
Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice.
Topics: Aldosterone; Animals; Cell Differentiation; Cells, Cultured; Fibroblast Growth Factor-23; Fibroblast | 2013 |