aldosterone and Sleep Apnea Syndromes studies

Sleep Apnea Syndromes: Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.

Research Excerpts

Excerpt	Relevance	Reference
"Obstructive sleep apnea can be detected with a careful history and various sleep studies."	5.32	Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. ( Calhoun, DA; Goodfriend, TL, 2004)
"Primary hyperaldosteronism is not as uncommon as previously thought, but its prevalence depends on the selected population."	1.34	Resistant hypertension: a methodological approach to diagnosis and treatment. ( Tamimi, NA, 2007)
"Obstructive sleep apnea can be detected with a careful history and various sleep studies."	1.32	Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. ( Calhoun, DA; Goodfriend, TL, 2004)
"To assess the effect of obstructive sleep apnea treatment on plasma renin activity (PRA) and plasma aldosterone seven male patients were studied under two conditions: untreated and treated with nasal continuous positive airways pressure (CPAP)."	1.28	Obstructive sleep apnea treatment: peripheral and central effects on plasma renin activity and aldosterone. ( Brandenberger, G; Follenius, M; Krauth, MO; Krieger, J; Sforza, F, 1991)
"Obstructive sleep apnea (OSA) patients have increased diuresis and natriuresis during sleep."	1.28	[Renal function and sleep apnea syndromes]. ( Barthelmebs, M; Coumaros, G; Imbs, JL; Krieger, J; Kurtz, D; Lehr, L; Sforza, E, 1989)

Research

Studies (13)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Epworth Sleepiness Score (ESS)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (15.38)	18.7374
1990's	6 (46.15)	18.2507
2000's	3 (23.08)	29.6817
2010's	2 (15.38)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Ke, X	1
Guo, W	1
Peng, H	1
Hu, C	1
Zhang, H	1
Peng, C	1
Wang, X	1
Martinez, FA	1
Goodfriend, TL	1
Calhoun, DA	1
Tamimi, NA	1
Mackay, TW	1
Fitzpatrick, MF	1
Freestone, S	1
Lee, MR	1
Douglas, NJ	1
Krieger, J	3
Saarelainen, S	1
Hasan, J	1
Siitonen, S	1
Seppälä, E	1
Maillard, D	1
Fineyre, F	1
Dreyfuss, D	1
Djedaini, K	1
Blanchet, F	1
Paycha, F	1
Dussaule, JC	1
Nitenberg, A	1
Hedner, J	1
Xiao, Y	1
Yin, K	1
Zheng, P	1
Follenius, M	1
Krauth, MO	1
Sforza, F	1
Brandenberger, G	1
Sforza, E	1
Barthelmebs, M	1
Imbs, JL	1
Lehr, L	1
Coumaros, G	1
Kurtz, D	1
Coccagna, G	1
Martinelli, P	1
Zucconi, M	1
Cirignotta, F	1
Ambrosetto, G	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Efficacy of Continuous Positive Airway Pressure (CPAP) on Blood Pressure Control of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome (OSAS).[NCT01508754]	Phase 4	125 participants (Actual)	Interventional	2012-01-31	Completed
Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea[NCT01196117]		18 participants (Actual)	Interventional	2004-11-15	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Epworth Sleepiness Score (ESS) is a scale to assess sleepiness during waking hours. The scale ranges from 0-24 with higher scores indicative of greater sleepiness. (NCT01196117)
Timeframe: Difference between Baseline(Day 0) and Average of Day 1,7,14.

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~ 7am, Day 7

Intervention	units on a scale (Median)
14 Days of Placebo Therapy, Then CPAP	10.7
14 Days of CPAP Therapy	8.9

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 7, 7am

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 0

Intervention	nmol/l (Mean)
CPAP>= 3 Hours Per Night	9.9
CPAP<3 Hours Per Night	13.3

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 0, 11pm

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 1

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	3.2
CPAP<3 Hours Per Night	1.2

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 1, 11pm

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 14

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	2.2
CPAP<3 Hours Per Night	1.8

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 14, 11pm

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 7

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	1.9
CPAP<3 Hours Per Night	2.2

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 7, 11pm

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~7am, Day 0

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	3.0
CPAP<3 Hours Per Night	2.5

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 0, 7am

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~7am, Day 1

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	12.5
CPAP<3 Hours Per Night	12.1

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 1, 7am

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~7am, Day 14

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	7.4
CPAP<3 Hours Per Night	13.6

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 14, 7am

Article	Year
Association of aldosterone excess and apnea-hypopnea index in patients with resistant hypertension. Scientific reports, 2017, 03-22, Volume: 7 Topics: Aged; Aldosterone; Coronary Vasospasm; Female; Humans; Hypertension; Male; Middle Aged; Sleep Apnea	2017
Aldosterone inhibition and cardiovascular protection: more important than it once appeared. Cardiovascular drugs and therapy, 2010, Volume: 24, Issue:4 Topics: Aldosterone; Atherosclerosis; Blood Vessels; Cardiomegaly; Cardiotonic Agents; Endothelium; Heart Fa	2010
Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:3 Topics: Aldosterone; Antihypertensive Agents; Drug Resistance; Humans; Hypertension; Male; Middle Aged; Mode	2004
Resistant hypertension: a methodological approach to diagnosis and treatment. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2007, Volume: 18, Issue:3 Topics: Aldosterone; Diagnosis, Differential; Drug Resistance; Humans; Hyperaldosteronism; Hypertension; Pat	2007
Hormonal control of sodium and water excretion in obstructive sleep apnoea. Scandinavian journal of urology and nephrology. Supplementum, 1995, Volume: 173 Topics: Aldosterone; Atrial Natriuretic Factor; Body Water; Guanosine Monophosphate; Hemodynamics; Humans; P	1995
Effect of nasal CPAP treatment on plasma volume, aldosterone and 24-h blood pressure in obstructive sleep apnoea. Journal of sleep research, 1996, Volume: 5, Issue:3 Topics: Adult; Aldosterone; Heart Rate; Humans; Male; Middle Aged; Positive-Pressure Respiration; Random All	1996
Pressure-heart rate responses to alpha-adrenergic stimulation and hormonal regulation in normotensive patients with obstructive sleep apnea. American journal of hypertension, 1997, Volume: 10, Issue:1 Topics: Adrenergic alpha-Agonists; Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Heart Rate	1997
[Significance of the changes of urinary uric acid, ANP, renin and aldosterone in sleep apnea syndrome patients]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2000, Volume: 23, Issue:1 Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Creatinine; Female; Humans; Male; Middle Aged; Renin;	2000
Obstructive sleep apnea treatment: peripheral and central effects on plasma renin activity and aldosterone. Sleep, 1991, Volume: 14, Issue:3 Topics: Adult; Aldosterone; Blood Volume; Humans; Hydrocortisone; Male; Oxygen; Positive-Pressure Respiratio	1991
[Renal function and sleep apnea syndromes]. Neurophysiologie clinique = Clinical neurophysiology, 1989, Volume: 19, Issue:3 Topics: Adult; Aldosterone; Creatinine; Cyclic GMP; Diuresis; Humans; Kidney; Male; Middle Aged; Natriuresis	1989
Sleep-related respiratory and haemodynamic changes in Shy-Drager syndrome: a case report. Journal of neurology, 1985, Volume: 232, Issue:5 Topics: Aldosterone; Autonomic Nervous System Diseases; Blood Pressure; Heart Rate; Humans; Male; Middle Age	1985

aldosterone and Sleep Apnea Syndromes