aldosterone has been researched along with Reperfusion Injury in 11 studies
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results show that MR antagonism administered, either immediately or 3 h after I/R, effectively prevented ischemic acute renal injury, indicating that spironolactone is a promising agent for preventing acute kidney injury once an ischemic insult has occurred." | 7.78 | Recovery from ischemic acute kidney injury by spironolactone administration. ( Barrera-Chimal, J; Bobadilla, NA; Cruz, C; Gamba, G; Garzón-Muvdi, J; Pérez-Villalva, R; Rodríguez-Romo, R; Sánchez-Pozos, K, 2012) |
| "The URB602 pretreatment in renal IRI, further enhanced renal 2-AG which is high affinity to both CB1 and CB2, and reduced renal COX-2 which is involved in the regulation of renal perfusion and inflammation." | 5.56 | The Critical Role of Cannabinoid Receptor 2 in URB602-Induced Protective Effects Against Renal Ischemia-Reperfusion Injury in the Rat. ( Gong, DY; Hai, KR; Ke, BW; Li, XH; Liu, YQ; Zuo, YX, 2020) |
| "Pretreatment with candesartan, spironolactone, or candesartan and spironolactone significantly inhibited retinal ischemic injury." | 5.38 | Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury. ( Fujita, T; Hirooka, K; Itano, T; Lei, B; Liu, Y; Nakamura, T; Nishiyama, A; Shiraga, F; Zhang, J, 2012) |
| "Our results show that MR antagonism administered, either immediately or 3 h after I/R, effectively prevented ischemic acute renal injury, indicating that spironolactone is a promising agent for preventing acute kidney injury once an ischemic insult has occurred." | 3.78 | Recovery from ischemic acute kidney injury by spironolactone administration. ( Barrera-Chimal, J; Bobadilla, NA; Cruz, C; Gamba, G; Garzón-Muvdi, J; Pérez-Villalva, R; Rodríguez-Romo, R; Sánchez-Pozos, K, 2012) |
| "The URB602 pretreatment in renal IRI, further enhanced renal 2-AG which is high affinity to both CB1 and CB2, and reduced renal COX-2 which is involved in the regulation of renal perfusion and inflammation." | 1.56 | The Critical Role of Cannabinoid Receptor 2 in URB602-Induced Protective Effects Against Renal Ischemia-Reperfusion Injury in the Rat. ( Gong, DY; Hai, KR; Ke, BW; Li, XH; Liu, YQ; Zuo, YX, 2020) |
| "Pretreatment with candesartan, spironolactone, or candesartan and spironolactone significantly inhibited retinal ischemic injury." | 1.38 | Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury. ( Fujita, T; Hirooka, K; Itano, T; Lei, B; Liu, Y; Nakamura, T; Nishiyama, A; Shiraga, F; Zhang, J, 2012) |
| "Spironolactone treatment prevents renal damage induced by ischemia-reperfusion (I/R), suggesting that renoprotection conferred by spironolactone is mediated by mineralocorticoid receptor (MR) blockade." | 1.35 | Adrenalectomy prevents renal ischemia-reperfusion injury. ( Bobadilla, NA; Cruz, C; Gamba, G; Ramírez, V; Trujillo, J; Uribe, N; Valdes, R, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumoto, T | 1 |
| Doi, S | 1 |
| Nakashima, A | 1 |
| Ike, T | 1 |
| Sasaki, K | 1 |
| Masaki, T | 1 |
| Li, XH | 1 |
| Liu, YQ | 1 |
| Gong, DY | 1 |
| Hai, KR | 1 |
| Ke, BW | 1 |
| Zuo, YX | 1 |
| Kudaibergenova, A | 1 |
| Aydogdu, N | 1 |
| Kandemir, N | 1 |
| Aydin, MA | 1 |
| Ashton, AW | 1 |
| Le, TY | 1 |
| Gomez-Sanchez, CE | 1 |
| Morel-Kopp, MC | 1 |
| McWhinney, B | 1 |
| Hudson, A | 1 |
| Mihailidou, AS | 1 |
| Barrera-Chimal, J | 2 |
| Bobadilla, NA | 4 |
| Jaisser, F | 1 |
| Ramírez, V | 2 |
| Trujillo, J | 1 |
| Valdes, R | 1 |
| Uribe, N | 2 |
| Cruz, C | 3 |
| Gamba, G | 3 |
| Liu, Y | 1 |
| Hirooka, K | 1 |
| Nishiyama, A | 1 |
| Lei, B | 1 |
| Nakamura, T | 1 |
| Itano, T | 1 |
| Fujita, T | 1 |
| Zhang, J | 1 |
| Shiraga, F | 1 |
| Sánchez-Pozos, K | 1 |
| Garzón-Muvdi, J | 1 |
| Pérez-Villalva, R | 1 |
| Rodríguez-Romo, R | 1 |
| Fouad, AA | 1 |
| Al-Mulhim, AS | 1 |
| Jresat, I | 1 |
| Morsy, MA | 1 |
| Sezai, A | 1 |
| Hata, M | 1 |
| Wakui, S | 1 |
| Shiono, M | 1 |
| Negishi, N | 1 |
| Kasamaki, Y | 1 |
| Saito, S | 1 |
| Kato, J | 1 |
| Minami, K | 1 |
| Mejía-Vilet, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Non Randomised Controlled Trial of Short Term Spironolactone Use for Prevention of Acute Kidney Injury After Cardiac Surgery[NCT02417896] | 150 participants (Anticipated) | Interventional | 2013-04-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for aldosterone and Reperfusion Injury
| Article | Year |
|---|---|
Mineralocorticoid Receptor Antagonism: A Promising Therapeutic Approach to Treat Ischemic AKI.
Topics: Acute Kidney Injury; Aldosterone; Animals; Humans; Mineralocorticoid Receptor Antagonists; Rats; Rep | 2016 |
1 trial available for aldosterone and Reperfusion Injury
| Article | Year |
|---|---|
Efficacy of low-dose continuous infusion of alpha-human atrial natriuretic peptide (hANP) during cardiac surgery: possibility of postoperative left ventricular remodeling effect.
Topics: Aged; Aldosterone; Arrhythmias, Cardiac; Atrial Natriuretic Factor; Blood Pressure; Cardiopulmonary | 2006 |
9 other studies available for aldosterone and Reperfusion Injury
| Article | Year |
|---|---|
Upregulation of Mineralocorticoid Receptor Contributes to Development of Salt-Sensitive Hypertension after Ischemia-Reperfusion Injury in Rats.
Topics: Aldosterone; Animals; Blood Pressure; Hypertension; Kidney; Rats; Receptors, Mineralocorticoid; Repe | 2022 |
The Critical Role of Cannabinoid Receptor 2 in URB602-Induced Protective Effects Against Renal Ischemia-Reperfusion Injury in the Rat.
Topics: Aldosterone; Animals; Biphenyl Compounds; Chromatography, Liquid; Interleukin-1beta; Male; Peroxidas | 2020 |
Investigation of Kisspeptin Role in Experimental Kidney Ischemia/Reperfusion Injury.
Topics: Acute Kidney Injury; Aldosterone; Angiotensin II; Animals; Arginine; Cell Adhesion Molecules; Creati | 2020 |
Role of Nongenomic Signaling Pathways Activated by Aldosterone During Cardiac Reperfusion Injury.
Topics: Aldosterone; Amines; Animals; Calmodulin-Binding Proteins; Male; Membrane Proteins; Mineralocorticoi | 2015 |
Adrenalectomy prevents renal ischemia-reperfusion injury.
Topics: Adrenalectomy; Aldosterone; Animals; Kidney; Kidney Diseases; Male; Nitric Oxide; Nitric Oxide Synth | 2009 |
Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; C | 2012 |
Recovery from ischemic acute kidney injury by spironolactone administration.
Topics: Acute Kidney Injury; Aldosterone; Animals; Drug Administration Schedule; HSP72 Heat-Shock Proteins; | 2012 |
Protective effects of captopril in diabetic rats exposed to ischemia/reperfusion renal injury.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Caspase 3; Creatinine; Di | 2013 |
Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone.
Topics: Aldosterone; Animals; Blotting, Western; Catalase; Glutathione Peroxidase; Immunohistochemistry; In | 2007 |