Page last updated: 2024-11-07

aldosterone and Reperfusion Injury

aldosterone has been researched along with Reperfusion Injury in 11 studies

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

ExcerptRelevanceReference
"Our results show that MR antagonism administered, either immediately or 3 h after I/R, effectively prevented ischemic acute renal injury, indicating that spironolactone is a promising agent for preventing acute kidney injury once an ischemic insult has occurred."7.78Recovery from ischemic acute kidney injury by spironolactone administration. ( Barrera-Chimal, J; Bobadilla, NA; Cruz, C; Gamba, G; Garzón-Muvdi, J; Pérez-Villalva, R; Rodríguez-Romo, R; Sánchez-Pozos, K, 2012)
"The URB602 pretreatment in renal IRI, further enhanced renal 2-AG which is high affinity to both CB1 and CB2, and reduced renal COX-2 which is involved in the regulation of renal perfusion and inflammation."5.56The Critical Role of Cannabinoid Receptor 2 in URB602-Induced Protective Effects Against Renal Ischemia-Reperfusion Injury in the Rat. ( Gong, DY; Hai, KR; Ke, BW; Li, XH; Liu, YQ; Zuo, YX, 2020)
"Pretreatment with candesartan, spironolactone, or candesartan and spironolactone significantly inhibited retinal ischemic injury."5.38Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury. ( Fujita, T; Hirooka, K; Itano, T; Lei, B; Liu, Y; Nakamura, T; Nishiyama, A; Shiraga, F; Zhang, J, 2012)
"Our results show that MR antagonism administered, either immediately or 3 h after I/R, effectively prevented ischemic acute renal injury, indicating that spironolactone is a promising agent for preventing acute kidney injury once an ischemic insult has occurred."3.78Recovery from ischemic acute kidney injury by spironolactone administration. ( Barrera-Chimal, J; Bobadilla, NA; Cruz, C; Gamba, G; Garzón-Muvdi, J; Pérez-Villalva, R; Rodríguez-Romo, R; Sánchez-Pozos, K, 2012)
"The URB602 pretreatment in renal IRI, further enhanced renal 2-AG which is high affinity to both CB1 and CB2, and reduced renal COX-2 which is involved in the regulation of renal perfusion and inflammation."1.56The Critical Role of Cannabinoid Receptor 2 in URB602-Induced Protective Effects Against Renal Ischemia-Reperfusion Injury in the Rat. ( Gong, DY; Hai, KR; Ke, BW; Li, XH; Liu, YQ; Zuo, YX, 2020)
"Pretreatment with candesartan, spironolactone, or candesartan and spironolactone significantly inhibited retinal ischemic injury."1.38Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury. ( Fujita, T; Hirooka, K; Itano, T; Lei, B; Liu, Y; Nakamura, T; Nishiyama, A; Shiraga, F; Zhang, J, 2012)
"Spironolactone treatment prevents renal damage induced by ischemia-reperfusion (I/R), suggesting that renoprotection conferred by spironolactone is mediated by mineralocorticoid receptor (MR) blockade."1.35Adrenalectomy prevents renal ischemia-reperfusion injury. ( Bobadilla, NA; Cruz, C; Gamba, G; Ramírez, V; Trujillo, J; Uribe, N; Valdes, R, 2009)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (27.27)29.6817
2010's5 (45.45)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Matsumoto, T1
Doi, S1
Nakashima, A1
Ike, T1
Sasaki, K1
Masaki, T1
Li, XH1
Liu, YQ1
Gong, DY1
Hai, KR1
Ke, BW1
Zuo, YX1
Kudaibergenova, A1
Aydogdu, N1
Kandemir, N1
Aydin, MA1
Ashton, AW1
Le, TY1
Gomez-Sanchez, CE1
Morel-Kopp, MC1
McWhinney, B1
Hudson, A1
Mihailidou, AS1
Barrera-Chimal, J2
Bobadilla, NA4
Jaisser, F1
Ramírez, V2
Trujillo, J1
Valdes, R1
Uribe, N2
Cruz, C3
Gamba, G3
Liu, Y1
Hirooka, K1
Nishiyama, A1
Lei, B1
Nakamura, T1
Itano, T1
Fujita, T1
Zhang, J1
Shiraga, F1
Sánchez-Pozos, K1
Garzón-Muvdi, J1
Pérez-Villalva, R1
Rodríguez-Romo, R1
Fouad, AA1
Al-Mulhim, AS1
Jresat, I1
Morsy, MA1
Sezai, A1
Hata, M1
Wakui, S1
Shiono, M1
Negishi, N1
Kasamaki, Y1
Saito, S1
Kato, J1
Minami, K1
Mejía-Vilet, JM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pilot Non Randomised Controlled Trial of Short Term Spironolactone Use for Prevention of Acute Kidney Injury After Cardiac Surgery[NCT02417896]150 participants (Anticipated)Interventional2013-04-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for aldosterone and Reperfusion Injury

ArticleYear
Mineralocorticoid Receptor Antagonism: A Promising Therapeutic Approach to Treat Ischemic AKI.
    Nephron, 2016, Volume: 134, Issue:1

    Topics: Acute Kidney Injury; Aldosterone; Animals; Humans; Mineralocorticoid Receptor Antagonists; Rats; Rep

2016

Trials

1 trial available for aldosterone and Reperfusion Injury

ArticleYear
Efficacy of low-dose continuous infusion of alpha-human atrial natriuretic peptide (hANP) during cardiac surgery: possibility of postoperative left ventricular remodeling effect.
    Circulation journal : official journal of the Japanese Circulation Society, 2006, Volume: 70, Issue:11

    Topics: Aged; Aldosterone; Arrhythmias, Cardiac; Atrial Natriuretic Factor; Blood Pressure; Cardiopulmonary

2006

Other Studies

9 other studies available for aldosterone and Reperfusion Injury

ArticleYear
Upregulation of Mineralocorticoid Receptor Contributes to Development of Salt-Sensitive Hypertension after Ischemia-Reperfusion Injury in Rats.
    International journal of molecular sciences, 2022, Jul-15, Volume: 23, Issue:14

    Topics: Aldosterone; Animals; Blood Pressure; Hypertension; Kidney; Rats; Receptors, Mineralocorticoid; Repe

2022
The Critical Role of Cannabinoid Receptor 2 in URB602-Induced Protective Effects Against Renal Ischemia-Reperfusion Injury in the Rat.
    Shock (Augusta, Ga.), 2020, Volume: 54, Issue:4

    Topics: Aldosterone; Animals; Biphenyl Compounds; Chromatography, Liquid; Interleukin-1beta; Male; Peroxidas

2020
Investigation of Kisspeptin Role in Experimental Kidney Ischemia/Reperfusion Injury.
    Folia medica, 2020, Mar-31, Volume: 62, Issue:1

    Topics: Acute Kidney Injury; Aldosterone; Angiotensin II; Animals; Arginine; Cell Adhesion Molecules; Creati

2020
Role of Nongenomic Signaling Pathways Activated by Aldosterone During Cardiac Reperfusion Injury.
    Molecular endocrinology (Baltimore, Md.), 2015, Volume: 29, Issue:8

    Topics: Aldosterone; Amines; Animals; Calmodulin-Binding Proteins; Male; Membrane Proteins; Mineralocorticoi

2015
Adrenalectomy prevents renal ischemia-reperfusion injury.
    American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:4

    Topics: Adrenalectomy; Aldosterone; Animals; Kidney; Kidney Diseases; Male; Nitric Oxide; Nitric Oxide Synth

2009
Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury.
    Experimental eye research, 2012, Volume: 96, Issue:1

    Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; C

2012
Recovery from ischemic acute kidney injury by spironolactone administration.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:8

    Topics: Acute Kidney Injury; Aldosterone; Animals; Drug Administration Schedule; HSP72 Heat-Shock Proteins;

2012
Protective effects of captopril in diabetic rats exposed to ischemia/reperfusion renal injury.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:2

    Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Caspase 3; Creatinine; Di

2013
Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone.
    American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:1

    Topics: Aldosterone; Animals; Blotting, Western; Catalase; Glutathione Peroxidase; Immunohistochemistry; In

2007