aldosterone and Proteinuria studies

Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.

Research Excerpts

Excerpt	Relevance	Reference
"73 m(2) and proteinuria with protein greater than 500 mg/g of creatinine on treatment with losartan, 100 mg/d, for longer than 6 months were screened in National Taiwan University Hospital."	9.13	Effect of pentoxifylline in addition to losartan on proteinuria and GFR in CKD: a 12-month randomized trial. ( Chen, YM; Chiang, WC; Lin, SL; Tsai, TJ; Wu, KD, 2008)
" The results established that the dual blockade of angiotensin II with enalapril and losartan has a greater clinical benefit for high-risk patients with hypertension and advanced diabetic nephropathy."	9.12	Dual blockade of angiotensin II with enalapril and losartan reduces proteinuria in hypertensive patients with type 2 diabetes. ( Hirata, A; Igarashi, M; Kadomoto, Y; Tominaga, M, 2006)
" The present study compared the chronic effects of efonidipine and amlodipine on proteinuria in patients with chronic glomerulonephritis."	9.12	Efonidipine reduces proteinuria and plasma aldosterone in patients with chronic glomerulonephritis. ( Akashiba, A; Ishimitsu, T; Kameda, T; Matsuoka, H; Minami, J; Numabe, A; Ohta, S; Ono, H; Takahashi, T; Yoshii, M, 2007)
"Aldosterone has emerged as a deleterious hormone in the kidney, for example as a potent inducer of proteinuria."	6.47	Endocrinological aspects of proteinuria and podocytopathy in diabetes: role of the aldosterone/mineralocorticoid receptor system. ( Fujita, T; Nagase, M, 2011)
"Hyperkalemia is a common complication of RAASi therapy and is associated with an increased risk of multiple adverse outcomes."	5.91	Outcomes in patients with cardiometabolic disease who develop hyperkalemia while treated with a renin-angiotensin-aldosterone system inhibitor. ( Johnson, M; McMahon, G; Morrison, FJ; Su, M; Turchin, A, 2023)
"Aldosterone has pro-fibrotic properties and is a potential target for additional intervention in patients with chronic renal disease showing resistance to therapy during treatment with angiotensin-converting enzyme inhibitors (ACEi)."	5.34	Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis. ( Hamming, I; Kramer, AB; Navis, G; van der Meulen, EF; van Goor, H, 2007)
"Malignant hypertension was induced with dietary indole-3-carbinol (0."	5.34	Aldosterone receptor antagonism alleviates proteinuria, but not malignant hypertension, in Cyp1a1-Ren2 transgenic rats. ( Graciano, ML; Mitchell, KD; Mullins, JJ; Ortiz, RM, 2007)
"Proteinuria was prominent in SHR/NDmcr-cp compared with nonobese SHR, which was accompanied by podocyte injury as evidenced by foot process effacement, induction of desmin and attenuation of nephrin."	5.33	Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. ( Ando, K; Fujita, T; Gotoda, T; Nagase, M; Nagase, T; Shibata, S; Yoshida, S, 2006)
"Pentoxifylline (PTX) is a phosphodiesterase inhibitor that possesses potent anti-inflammatory and immunomudulatory effects."	5.33	Pentoxifylline ameliorates proteinuria through suppression of renal monocyte chemoattractant protein-1 in patients with proteinuric primary glomerular diseases. ( Chen, YM; Chiang, WC; Lin, SL; Tsai, TJ; Wu, KD, 2006)
" In this study, we explored the effects of SP on urinary protein excretion in patients with Alport syndrome featuring persistent proteinuria in spite of the long-term use of ACEI (lisinopril) or both ACEI and ARB (candesartan)."	5.33	The effect of aldosterone blockade in patients with Alport syndrome. ( Iijima, K; Kaito, H; Kanda, K; Matsuo, M; Nakanishi, K; Nozu, K; Przybyslaw Krol, R; Yoshikawa, N; Yoshiya, K, 2006)
"A total of 25 patients with primary aldosteronism caused by Conn's adenoma, 29 patients with renovascular hypertension, and 29 patients with essential hypertension (EHT) were included in the present study."	5.33	Role of aldosterone in left ventricular hypertrophy in hypertension. ( Fujii, K; Iida, M; Matsumura, K; Oka, M; Oniki, H, 2006)
"Experimental toxemia of pregnancy was induced in 8 pregnant monkeys (Macacamulatta) by reducing the abdomiinal aorta to one-third of its original diameter during the last month of gestation."	5.26	Experimental toxemia of pregnancy in the monkey, with a preliminary report on renin and aldosterone. ( Abitbol, MM; Driscoll, SG; Gallo, GR; Ober, MB; Pirani, CL, 1977)
"Aliskiren combined with olmesartan reduces proteinuria in CKD patients."	5.16	Beneficial effect of aliskiren combined with olmesartan in reducing urinary protein excretion in patients with chronic kidney disease. ( Itabashi, M; Kojima, C; Moriyama, T; Nitta, K; Ogawa, T; Sugiura, H; Takei, T; Tsuchiya, K; Tsuruta, Y; Uchida, K, 2012)
"73 m(2) and proteinuria with protein greater than 500 mg/g of creatinine on treatment with losartan, 100 mg/d, for longer than 6 months were screened in National Taiwan University Hospital."	5.13	Effect of pentoxifylline in addition to losartan on proteinuria and GFR in CKD: a 12-month randomized trial. ( Chen, YM; Chiang, WC; Lin, SL; Tsai, TJ; Wu, KD, 2008)
" The results established that the dual blockade of angiotensin II with enalapril and losartan has a greater clinical benefit for high-risk patients with hypertension and advanced diabetic nephropathy."	5.12	Dual blockade of angiotensin II with enalapril and losartan reduces proteinuria in hypertensive patients with type 2 diabetes. ( Hirata, A; Igarashi, M; Kadomoto, Y; Tominaga, M, 2006)
" The present study compared the chronic effects of efonidipine and amlodipine on proteinuria in patients with chronic glomerulonephritis."	5.12	Efonidipine reduces proteinuria and plasma aldosterone in patients with chronic glomerulonephritis. ( Akashiba, A; Ishimitsu, T; Kameda, T; Matsuoka, H; Minami, J; Numabe, A; Ohta, S; Ono, H; Takahashi, T; Yoshii, M, 2007)
"Add-on losartan therapy did not improve proteinuria or ABP over one month of add on therapy."	5.09	Add-on angiotensin receptor blockade with maximized ACE inhibition. ( Agarwal, R, 2001)
"Hydrochlorothiazide (HCTZ) is used to manage hypertension and heart failure; however, its side effects include mild hypokalemia, metabolic abnormalities, and volume depletion, which might have deleterious effects on renal and endothelial function."	3.74	Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia. ( Byer, K; Croker, BP; Hu, H; Johnson, RJ; Mu, W; Nakagawa, T; Patel, JM; Reungjui, S; Roncal, CA; Simoni, J; Sitprija, V; Srinivas, T; Wesson, D, 2007)
"The increase in proteinuria after exercise in our patients is significant and is not prevented by ramipril therapy, but lasts less than 120 minutes."	3.72	Can young adult patients with proteinuric IgA nephropathy perform physical exercise? ( Andreucci, M; Caglioti, A; Cianfrone, P; Comi, N; Fuiano, G; Fuiano, L; Mancuso, D; Marino, F; Mazza, G; Zamboli, P, 2004)
"The differential effects of enalapril, losartan and nifedipine on proteinuria and intrarenal Ang II and bradykinin levels suggest that the ability of an antihypertensive to decrease proteinuria may depend on its ability to decrease kidney Ang II and bradykinin levels."	3.71	Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency. ( Campbell, DJ; Mackie, FE; Meyer, TW, 2002)
"Superimposed preeclampsia complicates about 20% of pregnancies in women with chronic hypertension and is associated with increased maternal and perinatal morbidity compared with preeclampsia alone."	2.82	Chronic hypertension and superimposed preeclampsia: screening and diagnosis. ( Kametas, NA; Nicolaides, KH; Nzelu, D, 2022)
"Aldosterone has emerged as a deleterious hormone in the kidney, for example as a potent inducer of proteinuria."	2.47	Endocrinological aspects of proteinuria and podocytopathy in diabetes: role of the aldosterone/mineralocorticoid receptor system. ( Fujita, T; Nagase, M, 2011)
"Aldosterone plays a significant role in the pathogenesis of arterial hypertension and renal disease."	2.44	Aldosterone and progression of renal disease. ( Wenzel, U, 2008)
"Aldosterone was also involved in the podocyte damage and proteinuria of metabolic syndrome model SHR/NDmcr-cp."	2.44	Aldosterone and glomerular podocyte injury. ( Fujita, T; Nagase, M, 2008)
"Idiopathic nodular glomerulosclerosis has a poor renal prognosis and is characterized by diffuse nodular glomerulosclerotic lesions in the absence of diabetic mellitus."	1.91	A case of idiopathic nodular glomerulosclerosis successfully treated by intensive blockade of the renin-angiotensin-aldosterone system. ( Arakawa, M; Hosojima, M; Ito, Y; Kabasawa, H; Narita, I; Saito, A; Suzuki, Y; Yamaguchi, H, 2023)
"Hyperkalemia is a common complication of RAASi therapy and is associated with an increased risk of multiple adverse outcomes."	1.91	Outcomes in patients with cardiometabolic disease who develop hyperkalemia while treated with a renin-angiotensin-aldosterone system inhibitor. ( Johnson, M; McMahon, G; Morrison, FJ; Su, M; Turchin, A, 2023)
"In primary aldosteronism (PA), renal impairment has been identified as an important comorbidity."	1.72	Primary aldosteronism with mild autonomous cortisol secretion increases renal complication risk. ( Ichijo, T; Inagaki, N; Izawa, S; Kakutani, M; Katabami, T; Kobayashi, H; Kurihara, I; Matsuba, R; Nakagawa, T; Naruse, M; Ogawa, Y; Sone, M; Takahashi, K; Tanabe, A; Tsuiki, M; Wada, N; Yamamoto, K; Yoshimoto, T, 2022)
"Type 1 diabetes was induced in female Wistar rats by a single tail vein injection of streptozotocin (STZ), and SPL was administrated daily by gavage, from days 3-21."	1.46	Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats. ( González-Ramírez, R; Molina-Jijón, E; Namorado-Tónix, C; Pedraza-Chaverri, J; Reyes, JL; Rodríguez-Muñoz, R, 2017)
"Treatment with rotenone, an inhibitor of mitochondrial complex I, significantly attenuated oxidative stress, mitochondrial dysfunction, and inflammasome response in aldosterone-infused rats."	1.42	Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation. ( Ding, W; Wang, B; Xu, C; Zhang, M, 2015)
"Hypertension is a leading contributor to cardiovascular mortality worldwide."	1.37	Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. ( Ando, K; Ayuzawa, N; Fujita, T; Ishikawa, A; Ishizawa, K; Kawarazaki, H; Kawarazaki, W; Miyoshi, J; Mu, S; Muraoka, K; Nagase, M; Shibata, S; Shimosawa, T; Takai, Y; Takeuchi, M; Yoshida, S, 2011)
"Aldosterone and high salt were associated with lower NO levels and greater renal oxidative stress."	1.37	Eplerenone suppresses aldosterone/ salt-induced expression of NOX-4. ( Adiyiah, J; Bayorh, MA; Eatman, D; Lyn, D; Rollins-Hairston, A, 2011)
"Treatment with azelnidipine suppressed aldosterone/mineralocorticoid receptor-dependent but not mineralocorticoid receptor-independent superoxide production in cultured rat mesangial cells."	1.35	Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats. ( Du, J; Fan, YY; Fu, H; Fujisawa, Y; Hitomi, H; Hosomi, N; Kimura, S; Kiyomoto, H; Kohno, M; Lu, XM; Nagai, Y; Nakano, D; Nishiyama, A; Ohmori, K, 2009)
"Treatment with eplerenone, a selective aldosterone receptor blocker, almost completely prevented podocyte damage and proteinuria, with normalization of elevated reduced nicotinamide-adenine dinucleotide phosphate oxidase activity."	1.34	Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. ( Fujita, T; Kawachi, H; Nagase, M; Shibata, S; Yoshida, S, 2007)
"Aldosterone has pro-fibrotic properties and is a potential target for additional intervention in patients with chronic renal disease showing resistance to therapy during treatment with angiotensin-converting enzyme inhibitors (ACEi)."	1.34	Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis. ( Hamming, I; Kramer, AB; Navis, G; van der Meulen, EF; van Goor, H, 2007)
"Malignant hypertension was induced with dietary indole-3-carbinol (0."	1.34	Aldosterone receptor antagonism alleviates proteinuria, but not malignant hypertension, in Cyp1a1-Ren2 transgenic rats. ( Graciano, ML; Mitchell, KD; Mullins, JJ; Ortiz, RM, 2007)
"Treatment with olmesartan (10 or 100 mg/kg/day) had no effect on blood pressure but attenuated proteinuria in a dose-dependent manner."	1.33	Augmentation of intrarenal angiotensin II levels in uninephrectomized aldosterone/salt-treated hypertensive rats; renoprotective effects of an ultrahigh dose of olmesartan. ( Abe, Y; Baba, R; Fan, YY; Fujita, M; Hosomi, N; Kimura, S; Kohno, M; Miyatake, A; Nagai, Y; Nishiyama, A; Sun, GP, 2006)
"Spironolactone treatment did not induce any significant differences in body weight, kidney/body weight ratio, serum creatinine concentration, blood glucose levels, or systolic blood pressure."	1.33	Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats. ( Cha, DR; Han, JY; Han, KH; Han, SY; Jee, YH; Kang, YS; Kim, HK; Kim, YS; Lee, MH, 2006)
" In this study, we explored the effects of SP on urinary protein excretion in patients with Alport syndrome featuring persistent proteinuria in spite of the long-term use of ACEI (lisinopril) or both ACEI and ARB (candesartan)."	1.33	The effect of aldosterone blockade in patients with Alport syndrome. ( Iijima, K; Kaito, H; Kanda, K; Matsuo, M; Nakanishi, K; Nozu, K; Przybyslaw Krol, R; Yoshikawa, N; Yoshiya, K, 2006)
"Proteinuria was prominent in SHR/NDmcr-cp compared with nonobese SHR, which was accompanied by podocyte injury as evidenced by foot process effacement, induction of desmin and attenuation of nephrin."	1.33	Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. ( Ando, K; Fujita, T; Gotoda, T; Nagase, M; Nagase, T; Shibata, S; Yoshida, S, 2006)
"Pentoxifylline (PTX) is a phosphodiesterase inhibitor that possesses potent anti-inflammatory and immunomudulatory effects."	1.33	Pentoxifylline ameliorates proteinuria through suppression of renal monocyte chemoattractant protein-1 in patients with proteinuric primary glomerular diseases. ( Chen, YM; Chiang, WC; Lin, SL; Tsai, TJ; Wu, KD, 2006)
"A total of 25 patients with primary aldosteronism caused by Conn's adenoma, 29 patients with renovascular hypertension, and 29 patients with essential hypertension (EHT) were included in the present study."	1.33	Role of aldosterone in left ventricular hypertrophy in hypertension. ( Fujii, K; Iida, M; Matsumura, K; Oka, M; Oniki, H, 2006)
"Aldosterone has emerged as a deleterious hormone in the heart, with mineralocorticoid receptor (MR) blockade reducing mortality in patients with severe heart failure."	1.33	Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria. ( Cockwell, P; Eardley, KS; Hewison, M; Howie, AJ; Hughes, SV; Lepenies, J; Quinkler, M; Stewart, PM; Zehnder, D, 2005)
"Spironolactone treatment decreased PAI-1 immunoreactivity and reduced in a dose-dependent fashion cardiac and renal damage."	1.32	Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II/NG-nitro-L-arginine methyl ester-induced myocardial injury. ( Adler, GK; Jonasson, L; Martinez-Vasquez, D; Mukasa, K; Oestreicher, EM; Roubsanthisuk, W; Stone, JR, 2003)
"Aldosterone promotes nephrosclerosis in several rat models, whereas aldosterone receptor antagonism blunts the effect of activation of the renin-angiotensin-aldosterone system (RAAS) on nephrosclerosis, independent of effects on blood pressure."	1.31	Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. ( Brown, NJ; Donnert, E; Fogo, AB; Freeman, M; Ma, L; Nakamura, I; Nakamura, S; Vaughan, DE, 2000)
"Proteinuria has been reported, sometimes in the nephrotic range, in patients with chronic complete renal artery occlusion."	1.31	Proteinuria in renal artery occlusion is related to active renin concentration and contralateral kidney size. ( Azizi, M; Chatellier, G; Plouin, PF; Rossignol, P, 2002)
"Captopril treatment reduced plasma aldosterone levels concomitant with marked reductions in proteinuria and the absence of histologic lesions of malignant nephrosclerosis."	1.30	Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats. ( Chander, PN; Rocha, R; Stier, CT; Zuckerman, A, 1999)
"Acute renal failure is seen with the acute abdominal compartment syndrome (AACS)."	1.30	Effect of increased renal venous pressure on renal function. ( Blocher, CR; Doty, JM; Fakhry, I; Gehr, TW; Pin, R; Saggi, BH; Sica, DA; Sugerman, HJ, 1999)
"Thus, sodium retention in the minimal change nephrotic syndrome was found only in oedema forming patients, and since this is not related to the plasma aldosterone concentration it may be caused by an intrarenal mechanism, probably sited in distal parts of the nephron."	1.27	Renal sodium handling in minimal change nephrotic syndrome. ( Berg, U; Bohlin, AB, 1984)
"Experimental toxemia of pregnancy was induced in 8 pregnant monkeys (Macacamulatta) by reducing the abdomiinal aorta to one-third of its original diameter during the last month of gestation."	1.26	Experimental toxemia of pregnancy in the monkey, with a preliminary report on renin and aldosterone. ( Abitbol, MM; Driscoll, SG; Gallo, GR; Ober, MB; Pirani, CL, 1977)
"The hypertension was accompanied by expansion of plasma volume, retention of sodium, and alteration in urinary Na/K ratio."	1.26	Isolation of a hypertension-producing compound from normal human urine. ( Bravo, EL; Bumpus, FM; Sen, S, 1977)

Research

Studies (142)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Change in Diastolic Blood Pressure by Cuff 8-10 Weeks Minus Baseline

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (25.35)	18.7374
1990's	10 (7.04)	18.2507
2000's	51 (35.92)	29.6817
2010's	37 (26.06)	24.3611
2020's	8 (5.63)	2.80

Authors	Studies
Grandt, LM	1
Schweighauser, A	1
Kovacevic, A	1
Francey, T	1
Kametas, NA	1
Nzelu, D	1
Nicolaides, KH	1
Katabami, T	1
Matsuba, R	1
Kobayashi, H	1
Nakagawa, T	2
Kurihara, I	1
Ichijo, T	1
Tsuiki, M	1
Wada, N	1
Ogawa, Y	2
Sone, M	1
Inagaki, N	1
Yoshimoto, T	1
Takahashi, K	1
Yamamoto, K	1
Izawa, S	1
Kakutani, M	1
Tanabe, A	1
Naruse, M	1
Lin, M	1
Heizhati, M	1
Gan, L	1
Hong, J	1
Wu, T	1
Xiamili, Z	1
Tong, L	1
Lin, Y	1
Li, N	1
Zhu, X	1
Gao, D	1
Albertazzi, V	1
Zhong, J	1
Ma, LJ	1
Du, L	1
Shyr, Y	1
Kon, V	1
Yang, HC	1
Fogo, AB	2
Ames, MK	1
Vaden, SL	1
Atkins, CE	1
Palerme, JS	1
Langston, CE	1
Grauer, GF	1
Shropshire, S	1
Bove, C	1
Webb, T	1
Yamaguchi, H	1
Hosojima, M	1
Kabasawa, H	1
Ito, Y	1
Suzuki, Y	1
Saito, A	1
Arakawa, M	1
Narita, I	1
Johnson, M	1
Morrison, FJ	1
McMahon, G	1
Su, M	2
Turchin, A	1
Nielsen, MR	1
Frederiksen-Møller, B	1
Zachar, R	1
Jørgensen, JS	1
Hansen, MR	1
Ydegaard, R	1
Svenningsen, P	2
Buhl, K	1
Jensen, BL	3
Molina-Jijón, E	1
Rodríguez-Muñoz, R	1
González-Ramírez, R	1
Namorado-Tónix, C	1
Pedraza-Chaverri, J	1
Reyes, JL	1
Giani, M	1
Mastrangelo, A	1
Villa, R	1
Turolo, S	1
Marra, G	1
Tirelli, AS	1
Hopfer, H	1
Edefonti, A	1
Dhoopun, AR	1
Yuan, Y	1
Huang, S	1
Zhu, C	1
Ding, G	2
Liu, B	1
Yang, T	1
Zhang, A	1
Faria, D	1
Rock, JR	1
Romao, AM	1
Schweda, F	1
Bandulik, S	1
Witzgall, R	1
Schlatter, E	1
Heitzmann, D	1
Pavenstädt, H	1
Herrmann, E	1
Kunzelmann, K	1
Schreiber, R	1
Linz, D	1
Mahfoud, F	1
Linz, B	1
Hohl, M	1
Schirmer, SH	1
Wirth, KJ	1
Böhm, M	1
Humalda, JK	1
Lambers Heerspink, HJ	1
Kwakernaak, AJ	1
Slagman, MC	1
Waanders, F	2
Vervloet, MG	1
Ter Wee, PM	1
Navis, G	3
de Borst, MH	1
Li, X	1
Yang, MS	1
Wallbach, M	1
Lehnig, LY	1
Schroer, C	1
Hasenfuss, G	1
Müller, GA	1
Wachter, R	1
Koziolek, MJ	1
Nagase, M	12
Brem, AS	1
Gong, R	1
Ding, W	1
Xu, C	1
Wang, B	1
Zhang, M	1
Lin, SL	2
Chen, YM	2
Chiang, WC	2
Wu, KD	2
Tsai, TJ	2
Cortinovis, M	1
Perico, N	1
Cattaneo, D	1
Remuzzi, G	1
Kastner, C	1
Pohl, M	1
Sendeski, M	1
Stange, G	1
Wagner, CA	2
Jensen, B	1
Patzak, A	1
Bachmann, S	1
Theilig, F	1
Manger, WM	1
Simchon, S	1
Stokes, MB	1
Reidy, JJ	1
Kumar, AR	1
Baer, L	1
Gallo, G	1
Haddy, FJ	1
Kooter, AJ	1
Smulders, YM	1
Fujita, T	8
Andoh, D	1
Yasuda, G	1
Umemura, S	1
Fan, YY	2
Kohno, M	3
Nakano, D	2
Hitomi, H	2
Nagai, Y	4
Fujisawa, Y	2
Lu, XM	1
Fu, H	1
Du, J	1
Ohmori, K	1
Hosomi, N	2
Kimura, S	3
Kiyomoto, H	2
Nishiyama, A	4
Wu, X	1
Lu, Y	1
Ku, E	1
Campese, VM	1
Toto, RD	1
Liang, W	1
Chen, C	1
Shi, J	1
Ren, Z	1
Hu, F	1
van Goor, H	2
Singhal, PC	1
Kujal, P	1
Chábová, VČ	1
Vernerová, Z	1
Walkowska, A	1
Kompanowska-Jezierska, E	1
Sadowski, J	1
Vaňourková, Z	1
Husková, Z	1
Opočenský, M	1
Skaroupková, P	1
Schejbalová, S	1
Kramer, HJ	1
Rakušan, D	1
Malý, J	1
Netuka, I	1
Vaněčková, I	1
Kopkan, L	1
Cervenka, L	1
Pimenta, E	2
Gordon, RD	1
Ahmed, AH	1
Cowley, D	1
Robson, D	1
Kogovsek, C	1
Stowasser, M	1
Bourgeois, MM	1
Richards, IS	1
Bayorh, MA	1
Rollins-Hairston, A	1
Adiyiah, J	1
Lyn, D	1
Eatman, D	1
Hunter, JD	1
Ravert, PK	1
Lassetter, JH	1
Williams, M	1
Schreier, B	1
Rabe, S	1
Schneider, B	1
Ruhs, S	1
Grossmann, C	1
Hauptmann, S	1
Blessing, M	1
Neumann, J	1
Gekle, M	1
Bertocchio, JP	1
Warnock, DG	1
Jaisser, F	1
Moriyama, T	1
Tsuruta, Y	1
Kojima, C	1
Itabashi, M	1
Sugiura, H	1
Takei, T	1
Ogawa, T	1
Uchida, K	1
Tsuchiya, K	1
Nitta, K	1
Friis, UG	1
Bistrup, C	2
Buhl, KB	1
Skøtt, O	2
Shibata, S	3
Mu, S	1
Kawarazaki, H	1
Muraoka, K	1
Ishizawa, K	1
Yoshida, S	3
Kawarazaki, W	1
Takeuchi, M	1
Ayuzawa, N	1
Miyoshi, J	1
Takai, Y	1
Ishikawa, A	1
Shimosawa, T	1
Ando, K	2
Nariai, T	1
Fujita, K	1
Mori, M	1
Katayama, S	1
Hori, S	1
Matsui, K	1
McQuarrie, EP	1
Freel, EM	1
Mark, PB	1
Fraser, R	3
Patel, RK	1
Dargie, HG	1
Connell, JM	1
Jardine, AG	1
Terata, S	1
Kikuya, M	1
Satoh, M	1
Ohkubo, T	1
Hashimoto, T	1
Hara, A	1
Hirose, T	1
Obara, T	1
Metoki, H	1
Inoue, R	1
Asayama, K	1
Kanno, A	1
Totsune, K	1
Hoshi, H	1
Satoh, H	2
Sato, H	1
Imai, Y	1
Mukoyama, M	1
Yokoi, H	1
Kasahara, M	1
Mori, K	1
Kato, Y	1
Kuwabara, T	1
Imamaki, H	1
Kawanishi, T	1
Koga, K	1
Ishii, A	1
Tokudome, T	1
Kishimoto, I	1
Sugawara, A	1
Nakao, K	1
Ohta, Y	1
Tsuchihashi, T	1
Kiyohara, K	1
Kitada, K	1
Liu, Y	1
Shibayama, Y	1
Shibata, H	1
Mori, H	1
Masaki, T	1
Kobori, H	1
Todkar, A	1
Di Chiara, M	1
Loffing-Cueni, D	1
Bettoni, C	1
Mohaupt, M	1
Loffing, J	1
Ibrahim, HN	1
Hostetter, TH	2
Panos, J	1
Michelis, MF	1
DeVita, MV	1
Lavie, RH	1
Wilkes, BM	1
Chander, PN	2
Rocha, R	2
Ranaudo, J	1
Singh, G	1
Zuckerman, A	2
Stier, CT	2
OLIVER, WJ	1
GENEST, J	1
FISHER, ER	1
KLEIN, HZ	1
GERASIMOVA, EN	1
PALEEVA, FM	2
RATNER, NA	1
DEODHAR, SD	1
CUPPAGE, FE	1
GABLEMAN, E	1
Oestreicher, EM	1
Martinez-Vasquez, D	1
Stone, JR	1
Jonasson, L	1
Roubsanthisuk, W	1
Mukasa, K	1
Adler, GK	1
Yao, L	1
Miyata, K	1
Yoshizumi, M	1
Kagami, S	1
Kondo, S	1
Shokoji, T	1
Abe, Y	2
Elijovich, F	1
Laffer, CL	1
Schiffrin, EL	1
Gavras, H	1
Amador, E	1
Fuiano, G	1
Mancuso, D	1
Cianfrone, P	1
Comi, N	1
Mazza, G	1
Marino, F	1
Fuiano, L	1
Zamboli, P	1
Caglioti, A	1
Andreucci, M	2
Lantelme, P	1
Rohrwasser, A	1
Vincent, M	1
Cheng, T	1
Gardier, S	1
Legedz, L	1
Bricca, G	1
Lalouel, JM	1
Milon, H	1
Thiesson, HC	1
Yoneda, M	1
Sanada, H	1
Yatabe, J	1
Midorikawa, S	1
Hashimoto, S	1
Sasaki, M	1
Katoh, T	1
Watanabe, T	1
Andrews, PM	1
Jose, PA	1
Felder, RA	1
Kitamura, K	1
Tomita, K	1
Quinkler, M	1
Zehnder, D	1
Eardley, KS	1
Lepenies, J	1
Howie, AJ	1
Hughes, SV	1
Cockwell, P	1
Hewison, M	1
Stewart, PM	1
Matsumura, K	1
Fujii, K	1
Oniki, H	1
Oka, M	1
Iida, M	1
Han, KH	1
Kang, YS	1
Han, SY	1
Jee, YH	1
Lee, MH	1
Han, JY	1
Kim, HK	1
Kim, YS	1
Cha, DR	1
Baba, R	1
Miyatake, A	1
Sun, GP	1
Fujita, M	1
Igarashi, M	1
Hirata, A	1
Kadomoto, Y	1
Tominaga, M	1
Horita, Y	1
Taura, K	1
Taguchi, T	1
Furusu, A	1
Kohno, S	1
Rump, LC	1
Kaito, H	1
Nozu, K	1
Iijima, K	1
Nakanishi, K	1
Yoshiya, K	1
Kanda, K	1
Przybyslaw Krol, R	1
Yoshikawa, N	1
Matsuo, M	1
Nagase, T	1
Gotoda, T	1
Kawachi, H	1
Kramer, AB	1
van der Meulen, EF	1
Hamming, I	1
Ishiguro, K	1
Sasamura, H	1
Sakamaki, Y	1
Itoh, H	1
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Tanemoto, M	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension[NCT05593055]	Phase 4	75 participants (Anticipated)	Interventional	2023-08-25	Recruiting
Uric Acid and Hypertension in African Americans[NCT00241839]	Phase 3	150 participants (Actual)	Interventional	2005-08-31	Completed
Effects of Low Sodium Intake on the Anti-proteinuric Efficacy of Olmesartan in Hypertensive Patients With Albuminuria Through Open-label Randomized Trial[NCT01552954]	Phase 4	269 participants (Actual)	Interventional	2012-02-29	Completed
[NCT00005757]		293 participants (Actual)	Observational	1997-09-30	Completed
Phase IV Open Label Uncontrolled Trial of the Dual Blockade of the Renin Angiotensin System With Enalapril Plus Valsartan Combined With Oral Methylprednisolone for the Treatment of Proteinuria in IGA Nephropathy[NCT00367562]	Phase 4	20 participants	Interventional	1996-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"The Diastolic BP was taken at Baseline and after 8-10 weeks of treatment or placebo while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol / placebo

Change in Overall Mean BP From Those Obtained by 24 Hour Ambulatory Blood Pressure Measurements (ABPM) 8-10 Weeks Minus Baseline.

Intervention	mm Hg (Mean)
A (Allopurinol)	3.44
B (Placebo)	-0.83

Subjects had 24 hr blood pressure monitoring (ABPM) at baseline and treatment end. The readings were averaged and the changes from baseline to treatment end were compared. (NCT00241839)
Timeframe: Baseline and end of treatment (8-10 weeks on allopurinol / placebo)

Change in Systolic Blood Pressure by Cuff After 8-10 Weeks Minus Baseline

Intervention	mm Hg (Mean)
A (Allopurinol)	-5.9
B (Placebo)	0.90

"The systolic BP was taken at Baseline and after 8-10 weeks of treatment on placebo, while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol or placebo

Change in Uric Acid (UA) Levels: Baseline Less End of Treatment

Intervention	mm Hg (Mean)
A (Allopurinol)	0.21
B (Placebo)	-0.95

Subjects on allopurinol are expected to lower their uric acid levels relative to placebo. (NCT00241839)
Timeframe: Baseline UA levels compared to end of treatment levels (8-10 weeks on allopurinol / placebo)

∆Albuminuria by 24-hour Urine Protein Excretion

Intervention	mg/dl (Mean)
A (Allopurinol)	2.29
B (Placebo)	0.14

"Change in albuminuria as a 24-hour urine protein excretion by intensive education of low salt diet during taking olmesartan~*In outcome measure data table, the 24-hour urine collection at 16th week was omitted in 3 out of 245 patients (1 for intensive education group and 2 for conventional education group). Values of each study week were mean of all participants on specific study week, but ∆albuminuria (week 8 - week 16) value was mean of ∆ values of 8 weeks-16 weeks in each individuals. Therefore, values of 3 patients were excluded in mean of ∆albuminuria (week 8 - week 16). That's why simple subtraction (week 8 - week 16) of values are not matched with the data." (NCT01552954)
Timeframe: changes from week 8 at week 16 (week 8 - week 16)

∆Hemoglobin (0 Week - 16 Weeks)

Intervention	mg/day (Mean)
	24hr-urine albumin (8th week)	24hr-urine albumin (16th week);n=124, 118	Mean of ∆albuminuria (week 8-week 16); n=124, 118
Conventional Education of Low-salt Diet Group	483.5	487.3	-0.4
Intensive Education of Low-salt Diet Group	569.9	417.4	154.0

The change of hemoglobin after prescription of Olmesartan (NCT01552954)
Timeframe: 0 week, 16 weeks

Na Excretion Change in 24 Hour-urine Collection Between Weeks 8 and 16

Intervention	g/dL (Mean)
	Hemoglobin (week 0)	Hemoglobin (week 8)	Hemoglobin (week 16)	Hemoglobin changes from week 0 at week 16
Conventional Education of Low-salt Diet Group	13.8	13.5	13.3	0.46
Intensive Education of Low-salt Diet Group	14.0	13.7	13.4	0.62

Change of sodium excretion rate in 24 hour-urine collection by intensive education for low salt diet at week 16 (NCT01552954)
Timeframe: week 8 and week 16

Systolic and Diastolic Blood Pressure Change Between Weeks 8 and 16

Intervention	mEq/day (Mean)
	week 8	week 16; n=124, 118	∆Na excretion (week 8 - week 16);n=124, 118
Conventional Education of Low-salt Diet Group	155.5	147.1	9.0
Intensive Education of Low-salt Diet Group	157.4	122.1	35.4

Change in Systolic and Diastolic Blood Pressure from Week 8 to Week 16 in the Intensive Education Group compared to the Conventional Education Group (NCT01552954)
Timeframe: week 8 and week 16

Intervention	mm Hg (Mean)
	Systolic BP at week 8	Systolic BP at week 16	sBP changes from week 8 at week 16	Diastolic BP at week 8	Diastolic BP at week 16	dBP changes from week 8 at week 16
Conventional Education of Low-salt Diet Group	121.8	121.2	0.6	73.4	74.8	-0.7
Intensive Education of Low-salt Diet Group	122.1	120.4	1.7	73.6	73.1	0.5

Article	Year
Chronic hypertension and superimposed preeclampsia: screening and diagnosis. American journal of obstetrics and gynecology, 2022, Volume: 226, Issue:2S Topics: Aldosterone; Angiogenic Proteins; Biomarkers; Chronic Disease; Cytokines; Female; Humans; Hypertensi	2022
Effects of T-type calcium channel blockers on renal function and aldosterone in patients with hypertension: a systematic review and meta-analysis. PloS one, 2014, Volume: 9, Issue:10 Topics: Adult; Aged; Aldosterone; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Ty	2014
Recent topics on podocytes and aldosterone. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2015, Volume: 25, Issue:2 Topics: Aldosterone; Animals; Disease Models, Animal; Humans; Hypertension; Metabolic Syndrome; Mice; Podocy	2015
Therapeutic targeting of aldosterone: a novel approach to the treatment of glomerular disease. Clinical science (London, England : 1979), 2015, Volume: 128, Issue:9 Topics: Aldosterone; Animals; Drug Design; Fibrosis; Humans; Kidney Diseases; Kidney Glomerulus; Mineralocor	2015
Aldosterone and progression of kidney disease. Therapeutic advances in cardiovascular disease, 2009, Volume: 3, Issue:2 Topics: Aldosterone; Animals; Chronic Disease; Clinical Trials as Topic; Disease Models, Animal; Disease Pro	2009
[Aldosterone block in proteinuria]. Nederlands tijdschrift voor geneeskunde, 2009, Apr-11, Volume: 153, Issue:15 Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Disease Progression; Humans; Kidney Diseases;	2009
Mineralocorticoid receptor activation in obesity hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2009, Volume: 32, Issue:8 Topics: Aldosterone; Animals; Biological Evolution; Humans; Hypertension; Ligands; Metabolic Syndrome; Miner	2009
[Novel evidence for sodium sensitivity and renal impairment]. Nihon Jinzo Gakkai shi, 2009, Volume: 51, Issue:4 Topics: Aldosterone; Blood Pressure; Circadian Rhythm; Glomerular Filtration Rate; Kidney; Kidney Diseases;	2009
Urinalysis: a review of methods and procedures. Critical care nursing clinics of North America, 2010, Volume: 22, Issue:1 Topics: Aldosterone; Chorionic Gonadotropin; Creatinine; Critical Care; Electrolytes; Humans; Hydrocortisone	2010
[Chronic kidney disease and the aldosterone/mineralocorticoid receptor system]. Nihon Jinzo Gakkai shi, 2010, Volume: 52, Issue:2 Topics: Aldosterone; Animals; Chronic Disease; Eplerenone; Humans; Kidney Diseases; Metabolic Syndrome; Mine	2010
Activation of the aldosterone/mineralocorticoid receptor system in chronic kidney disease and metabolic syndrome. Clinical and experimental nephrology, 2010, Volume: 14, Issue:4 Topics: Aldosterone; Animals; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Humans; Hypertensi	2010
Aldosterone in the pathogenesis of chronic kidney disease and proteinuria. Current hypertension reports, 2010, Volume: 12, Issue:4 Topics: Aldosterone; Disease Progression; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Miner	2010
Aldosterone blockade in chronic kidney disease: can it improve outcome? Current opinion in nephrology and hypertension, 2010, Volume: 19, Issue:5 Topics: Aldosterone; Blood Pressure; Cardiovascular Diseases; Chronic Disease; Clinical Trials as Topic; Hum	2010
Endocrinological aspects of proteinuria and podocytopathy in diabetes: role of the aldosterone/mineralocorticoid receptor system. Current diabetes reviews, 2011, Volume: 7, Issue:1 Topics: Aldosterone; Animals; Diabetic Nephropathies; Endocrinology; Humans; Models, Biological; Podocytes;	2011
Renal protection in diabetes. Advance for NPs & PAs, 2011, Volume: 2, Issue:1 Topics: Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Blood Press	2011
Mineralocorticoid receptor activation and blockade: an emerging paradigm in chronic kidney disease. Kidney international, 2011, Volume: 79, Issue:10 Topics: Aldosterone; Animals; Chronic Disease; Cyclosporine; Diabetic Nephropathies; Humans; Kidney Diseases	2011
Physiological regulation of epithelial sodium channel by proteolysis. Current opinion in nephrology and hypertension, 2011, Volume: 20, Issue:5 Topics: Aldosterone; Animals; Epithelial Cells; Epithelial Sodium Channels; Humans; Ion Channel Gating; Ion	2011
[Mineralocorticoid receptor: an update]. Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70, Issue:9 Topics: Aldosterone; Animals; Heart Diseases; Humans; Kidney Diseases; Mineralocorticoid Receptor Antagonist	2012
Aldosterone in renal disease. Current opinion in nephrology and hypertension, 2003, Volume: 12, Issue:2 Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Chronic Disease; Clinical Trials as	2003
[Roll of aldosterone in pathogenesis of kidney disorders]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2005, Jul-10, Volume: 94, Issue:7 Topics: Aldosterone; Animals; Body Water; Disease Models, Animal; Eplerenone; Humans; Hypertension; Kidney D	2005
Secondary rise of albuminuria under AT1-receptor blockade--what is the potential role of aldosterone escape? Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:1 Topics: Albuminuria; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Humans;	2007
[Metabolic syndrome and aldosterone]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2006, Sep-10, Volume: 95, Issue:9 Topics: Aldosterone; Animals; Humans; Intra-Abdominal Fat; Kidney Glomerulus; Metabolic Syndrome; Obesity; O	2006
Aldosterone and progression of renal disease. Current opinion in nephrology and hypertension, 2008, Volume: 17, Issue:1 Topics: Aldosterone; Animals; Disease Progression; Humans; Hypertension; Kidney Diseases; Prorenin Receptor;	2008
Aldosterone and glomerular podocyte injury. Clinical and experimental nephrology, 2008, Volume: 12, Issue:4 Topics: Aldosterone; Animals; Disease Models, Animal; Humans; Hypertension; Metabolic Syndrome; Oxidative St	2008
Experimental toxemia of pregnancy: review and speculation. Pathology annual, 1977, Volume: 12 Pt 2 Topics: Aldosterone; Angiotensin II; Animals; Disease Models, Animal; Dogs; Endocrine Glands; Female; Humans	1977
Recent progress in the control of aldosterone secretion. Recent progress in hormone research, 1986, Volume: 42 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Animals; Blood Pressure; Blood Proteins; D	1986
Improvements of metabolic and diagnostic assessment of human renal allotransplants. Surgery annual, 1972, Volume: 4 Topics: Adrenal Glands; Aldosterone; Anemia; Biopsy, Needle; Cholinesterases; Erythropoietin; Fibrin; Graft	1972

Article	Year
Fibroblast growth factor 23 and the antiproteinuric response to dietary sodium restriction during renin-angiotensin-aldosterone system blockade. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2015, Volume: 65, Issue:2 Topics: Adult; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Cross-Over Studies;	2015
Impact of baroreflex activation therapy on renal function--a pilot study. American journal of nephrology, 2014, Volume: 40, Issue:4 Topics: Aged; Aldosterone; Baroreflex; Blood Pressure; Female; Glomerular Filtration Rate; Humans; Hypertens	2014
Effect of pentoxifylline in addition to losartan on proteinuria and GFR in CKD: a 12-month randomized trial. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2008, Volume: 52, Issue:3 Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Blood Glucose; Blood Pressure; Chemokine CCL2;	2008
Beneficial effect of aliskiren combined with olmesartan in reducing urinary protein excretion in patients with chronic kidney disease. International urology and nephrology, 2012, Volume: 44, Issue:3 Topics: Adult; Aldosterone; Amides; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Antihyper	2012
Combined converting enzyme inhibition and angiotensin receptor blockade reduce proteinuria greater than converting enzyme inhibition alone: insights into mechanism. Clinical nephrology, 2003, Volume: 60, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Disease Progr	2003
Dual blockade of angiotensin II with enalapril and losartan reduces proteinuria in hypertensive patients with type 2 diabetes. Endocrine journal, 2006, Volume: 53, Issue:4 Topics: Aged; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents	2006
Aldosterone breakthrough during therapy with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in proteinuric patients with immunoglobulin A nephropathy. Nephrology (Carlton, Vic.), 2006, Volume: 11, Issue:5 Topics: Adult; Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitor	2006
Proteinuria-lowering effect of heparin therapy in diabetic nephropathy without affecting the renin-angiotensin-aldosterone system. Clinical journal of the American Society of Nephrology : CJASN, 2007, Volume: 2, Issue:1 Topics: Adult; Aged; Aldosterone; Blood Pressure; Diabetic Nephropathies; Enoxaparin; Female; Fibrinolytic A	2007
Efonidipine reduces proteinuria and plasma aldosterone in patients with chronic glomerulonephritis. Hypertension research : official journal of the Japanese Society of Hypertension, 2007, Volume: 30, Issue:7 Topics: Adult; Aged; Aldosterone; Amlodipine; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-	2007
Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan. Journal of the American Society of Nephrology : JASN, 2008, Volume: 19, Issue:5 Topics: Adult; Aged; Aldosterone; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Drug Interact	2008
Effect of angiotensin-converting enzyme and calcium channel inhibition on progression of IgA nephropathy. Contributions to nephrology, 1995, Volume: 111 Topics: Aldosterone; Blood Pressure; Combined Modality Therapy; Diet, Sodium-Restricted; Disease Progression	1995
Do obesity and non-insulin dependent diabetes mellitus aggravate exercise-induced microproteinuria? Clinica chimica acta; international journal of clinical chemistry, 1998, Jul-28, Volume: 275, Issue:2 Topics: Adolescent; Adult; Albumins; Aldosterone; beta 2-Microglobulin; Catecholamines; Diabetes Mellitus, T	1998
A subdepressor low dose of ramipril lowers urinary protein excretion without increasing plasma potassium. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1999, Volume: 33, Issue:3 Topics: Adult; Aged; Aldosterone; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Drug Admin	1999
Add-on angiotensin receptor blockade with maximized ACE inhibition. Kidney international, 2001, Volume: 59, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin Receptor Antagonists; Angiotens	2001
Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 38, Issue:1 Topics: Adult; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Bloo	2001
Glomerular and hormonal responses to dietary protein intake in human renal disease. The American journal of physiology, 1987, Volume: 253, Issue:6 Pt 2 Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aldosterone; Blood Proteins; Dextrans; Diabetic Nephropathies;	1987

Article	Year
The circulating renin-angiotensin-aldosterone system is down-regulated in dogs with glomerular diseases compared to other chronic kidney diseases with low-grade proteinuria. PloS one, 2022, Volume: 17, Issue:1 Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Azotemia; Blood Urea Nitrogen; Dog Diseases; Dogs;	2022
Primary aldosteronism with mild autonomous cortisol secretion increases renal complication risk. European journal of endocrinology, 2022, Apr-25, Volume: 186, Issue:6 Topics: Aldosterone; Cross-Sectional Studies; Female; Humans; Hydrocortisone; Hyperaldosteronism; Male; Prot	2022
Higher plasma renin activity is associated with increased kidney damage risk in patients with hypertension and glucose metabolic disorders. Journal of clinical hypertension (Greenwich, Conn.), 2022, Volume: 24, Issue:6 Topics: Aldosterone; Glucose Metabolism Disorders; Humans; Hypertension; Kidney; Proteinuria; Renal Insuffic	2022
Podocyte-Related Mechanisms Underlying Survival Benefit of Long-Term Angiotensin Receptor Blocker. International journal of molecular sciences, 2022, May-27, Volume: 23, Issue:11 Topics: Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bl	2022
Prevalence of aldosterone breakthrough in dogs receiving renin-angiotensin system inhibitors for proteinuric chronic kidney disease. Journal of veterinary internal medicine, 2022, Volume: 36, Issue:6 Topics: Aldosterone; Animals; Antihypertensive Agents; Creatinine; Dog Diseases; Dogs; Prevalence; Prospecti	2022
A case of idiopathic nodular glomerulosclerosis successfully treated by intensive blockade of the renin-angiotensin-aldosterone system. CEN case reports, 2023, Volume: 12, Issue:3 Topics: Aged; Aldosterone; Angiotensins; Arteriosclerosis; Diabetic Nephropathies; Female; Humans; Proteinur	2023
Outcomes in patients with cardiometabolic disease who develop hyperkalemia while treated with a renin-angiotensin-aldosterone system inhibitor. American heart journal, 2023, Volume: 258 Topics: Adult; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Coronary Arte	2023
Urine exosomes from healthy and hypertensive pregnancies display elevated level of α-subunit and cleaved α- and γ-subunits of the epithelial sodium channel-ENaC. Pflugers Archiv : European journal of physiology, 2017, Volume: 469, Issue:9 Topics: Adult; Aldosterone; Epithelial Sodium Channels; Exosomes; Female; Fibrinolysin; Humans; Hypertension	2017
Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats. PloS one, 2017, Volume: 12, Issue:5 Topics: Aldosterone; Animals; Claudin-4; Claudins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type	2017
Alport syndrome: the effects of spironolactone on proteinuria and urinary TGF-β1. Pediatric nephrology (Berlin, Germany), 2013, Volume: 28, Issue:9 Topics: Adolescent; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Child; Creatinine	2013
Mitochondrial dysfunction is an early event in aldosterone-induced podocyte injury. American journal of physiology. Renal physiology, 2013, Aug-15, Volume: 305, Issue:4 Topics: Aldosterone; Animals; Blotting, Western; Cell Culture Techniques; DNA, Mitochondrial; F2-Isoprostane	2013
The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. Kidney international, 2014, Volume: 85, Issue:6 Topics: Adenosine Triphosphate; Aldosterone; Animals; Anoctamin-1; Cells, Cultured; Chloride Channels; Femal	2014
Effect of obstructive respiratory events on blood pressure and renal perfusion in a pig model for sleep apnea. American journal of hypertension, 2014, Volume: 27, Issue:10 Topics: Aldosterone; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Creatinine; Disea	2014
Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation. Medical science monitor : international medical journal of experimental and clinical research, 2015, Oct-17, Volume: 21 Topics: Adenosine Triphosphate; Aldosterone; Animals; Carrier Proteins; DNA, Mitochondrial; Glomeruloscleros	2015
Effects of receptor-mediated endocytosis and tubular protein composition on volume retention in experimental glomerulonephritis. American journal of physiology. Renal physiology, 2009, Volume: 296, Issue:4 Topics: Aldosterone; Animals; Aquaporin 1; Aquaporin 2; Autoantibodies; Blood Pressure; Cyclooxygenase 2; Di	2009
Renal functional, not morphological, abnormalities account for salt sensitivity in Dahl rats. Journal of hypertension, 2009, Volume: 27, Issue:3 Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Cyclic GMP; Diastole; Dose-Response Relationsh	2009
Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats. Journal of hypertension, 2009, Volume: 27, Issue:9 Topics: Aldosterone; Animals; Azetidinecarboxylic Acid; Blood Pressure; Body Weight; Calcium Channel Blocker	2009
Disparate effects of eplerenone, amlodipine and telmisartan on podocyte injury in aldosterone-infused rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:3 Topics: Albuminuria; Aldosterone; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosis;	2011
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects? Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:12 Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme	2010
Unilateral adrenalectomy improves urinary protein excretion but does not abolish its relationship to sodium excretion in patients with aldosterone-producing adenoma. Journal of human hypertension, 2011, Volume: 25, Issue:10 Topics: Adenoma; Adrenalectomy; Adult; Aldosterone; Blood Pressure; Female; Fludrocortisone; Humans; Hyperal	2011
Gender-specific differences in the urinary expression of aldosterone, IL-1α and IL-1β. Biomarkers in medicine, 2010, Volume: 4, Issue:6 Topics: Aldosterone; C-Reactive Protein; Creatinine; Female; Humans; Interleukin-1alpha; Interleukin-1beta;	2010
Eplerenone suppresses aldosterone/ salt-induced expression of NOX-4. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2011, Volume: 12, Issue:3 Topics: Acetophenones; Aldosterone; Animals; Blood Pressure; Blotting, Western; Body Weight; Dinoprost; Eple	2011
Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells. Hypertension research : official journal of the Japanese Society of Hypertension, 2011, Volume: 34, Issue:5 Topics: Aldosterone; Animals; Blood Pressure; Collagen; Extracellular Matrix; Fibronectins; Fibrosis; Kidney	2011
Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. The Journal of clinical investigation, 2011, Volume: 121, Issue:8 Topics: Aldosterone; Animals; Hypertension; Kidney; Kidney Diseases; Male; Mice; Mice, Transgenic; Models, B	2011
Antihypertensive and cardiorenal protective effects of SM-368229, a novel mineralocorticoid receptor antagonist, in aldosterone/salt-treated rats. Pharmacology, 2012, Volume: 89, Issue:1-2 Topics: Acetylglucosaminidase; Aldosterone; Animals; Antihypertensive Agents; Benzoxazines; Biomarkers; Bloo	2012
Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chronic kidney disease. Clinical science (London, England : 1979), 2012, Volume: 123, Issue:5 Topics: Aged; Aldosterone; Biomarkers; Cross-Sectional Studies; Desoxycorticosterone; Female; Gas Chromatogr	2012
Plasma renin activity and the aldosterone-to-renin ratio are associated with the development of chronic kidney disease: the Ohasama Study. Journal of hypertension, 2012, Volume: 30, Issue:8 Topics: Aldosterone; Biomarkers; Comorbidity; Creatinine; Female; Follow-Up Studies; Glomerular Filtration R	2012
Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury. Journal of the American Society of Nephrology : JASN, 2012, Volume: 23, Issue:7 Topics: Acute Kidney Injury; Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Cells, Cultured;	2012
Influence of salt intake on target organ damages in treated hypertensive patients. Clinical and experimental hypertension (New York, N.Y. : 1993), 2012, Volume: 34, Issue:5 Topics: Aged; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antih	2012
Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats. PloS one, 2012, Volume: 7, Issue:7 Topics: Adrenalectomy; Aldosterone; Animals; Biomarkers; Blood Pressure; Cyclic N-Oxides; Ethidium; Feeding	2012
Aldosterone deficiency adversely affects pregnancy outcome in mice. Pflugers Archiv : European journal of physiology, 2012, Volume: 464, Issue:4 Topics: Aldosterone; Animals; Blood Pressure; Cytochrome P-450 CYP11B2; Diet; Disease Models, Animal; Female	2012
Aldosterone plays a pivotal role in the pathogenesis of thrombotic microangiopathy in SHRSP. Journal of the American Society of Nephrology : JASN, 2003, Volume: 14, Issue:8 Topics: Aldosterone; Animals; Antineoplastic Agents, Hormonal; Blood Pressure; Body Weight; Creatinine; Dexa	2003
PHYSIOLOGIC RESPONSES ASSOCIATED WITH STEROID-INDUCED DIURESIS IN THE NEPHROTIC SYNDROME. The Journal of laboratory and clinical medicine, 1963, Volume: 62 Topics: Aldosterone; Child; Colloids; Diuresis; Humans; Hydrocortisone; Nephrotic Syndrome; Proteinuria; Ser	1963
[PHYSIOPATHOLOGY OF NEPHROTIC EDEMA; ROLE OF ALDOSTERONE]. L'union medicale du Canada, 1963, Volume: 92 Topics: Aldosterone; Angiotensins; Edema; Humans; Hyperaldosteronism; Nephrotic Syndrome; Proteinuria; Renin	1963
EFFECT OF SODIUM ON JUXTAGLOMERULAR INDEX AND ZONA GLOMERULOSA IN EXPERIMENTAL NEPHROSIS. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1963, Volume: 114 Topics: Adrenal Glands; Aldosterone; Angiotensins; Ascites; Blood Pressure; Blood Pressure Determination; Bl	1963
[SIGNIFICANCE OF ALDOSTERONE IN THE PATHOGENESIS OF THE EDEMATOUS AND HYPERTENSIVE SYNDROME IN KIDNEY DISEASES]. Terapevticheskii arkhiv, 1964, Volume: 36 Topics: Aldosterone; Blood; Edema; Glomerulonephritis; Humans; Hyperaldosteronism; Hypertension; Hypertensio	1964
STUDIES ON THE MECHANISM OF EXPERIMENTAL PROTEINURIA INDUCED BY RENIN. The Journal of experimental medicine, 1964, Oct-01, Volume: 120 Topics: Adrenalectomy; Aldosterone; Angiotensin II; Angiotensins; Basement Membrane; Desoxycorticosterone; E	1964
Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II/NG-nitro-L-arginine methyl ester-induced myocardial injury. Circulation, 2003, Nov-18, Volume: 108, Issue:20 Topics: Aldosterone; Angiotensin II; Animals; Cardiovascular Diseases; Coronary Artery Disease; Disease Mode	2003
Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:4 Topics: Aldosterone; Animals; Cyclic N-Oxides; Eplerenone; Hypertension; JNK Mitogen-Activated Protein Kinas	2004
Endothelin-aldosterone interaction and proteinuria in low-renin hypertension. Journal of hypertension, 2004, Volume: 22, Issue:3 Topics: Adult; Aldosterone; Blood Pressure; Endothelins; Female; Humans; Hypertension, Renal; Male; Middle A	2004
Can young adult patients with proteinuric IgA nephropathy perform physical exercise? American journal of kidney diseases : the official journal of the National Kidney Foundation, 2004, Volume: 44, Issue:2 Topics: Adult; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Case-Control Studies; Creatinine; Dise	2004
Significance of urinary angiotensinogen in essential hypertension as a function of plasma renin and aldosterone status. Journal of hypertension, 2005, Volume: 23, Issue:4 Topics: Aged; Aldosterone; Angiotensinogen; Blood Pressure; Female; Humans; Hypertension, Renal; Male; Middl	2005
Reduced activity of 11beta-hydroxysteroid dehydrogenase type 2 is not responsible for sodium retention in nephrotic rats. Acta physiologica Scandinavica, 2005, Volume: 184, Issue:2 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Animals; Corticosterone; Dexamethasone; Di	2005
Differential effects of angiotensin II type-1 receptor antisense oligonucleotides on renal function in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979), 2005, Volume: 46, Issue:1 Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Diure	2005
Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria. Circulation, 2005, Sep-06, Volume: 112, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldosterone; Biopsy; Blood Pressure; Chemokine CCL2; Fem	2005
Role of aldosterone in left ventricular hypertrophy in hypertension. American journal of hypertension, 2006, Volume: 19, Issue:1 Topics: Adrenergic beta-Antagonists; Adrenocortical Adenoma; Adult; Aldosterone; Angiotensin II; Blood Press	2006
Pentoxifylline ameliorates proteinuria through suppression of renal monocyte chemoattractant protein-1 in patients with proteinuric primary glomerular diseases. Kidney international, 2006, Volume: 69, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Chemokine CCL2; Creatinine; Cytokines; Female; Glomerul	2006
Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats. Kidney international, 2006, Volume: 70, Issue:1 Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aldosterone; Animals; Collagen Type IV; Connective Tissue Gro	2006
Augmentation of intrarenal angiotensin II levels in uninephrectomized aldosterone/salt-treated hypertensive rats; renoprotective effects of an ultrahigh dose of olmesartan. Hypertension research : official journal of the Japanese Society of Hypertension, 2006, Volume: 29, Issue:3 Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Body	2006
The effect of aldosterone blockade in patients with Alport syndrome. Pediatric nephrology (Berlin, Germany), 2006, Volume: 21, Issue:12 Topics: Adolescent; Adult; Aldosterone; Child; Female; Glomerular Filtration Rate; Humans; Male; Mineralocor	2006
Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. Journal of the American Society of Nephrology : JASN, 2006, Volume: 17, Issue:12 Topics: Adipocytes; Adrenal Glands; Aldosterone; Animals; Cyclic N-Oxides; Disease Models, Animal; Eplerenon	2006
Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension (Dallas, Tex. : 1979), 2007, Volume: 49, Issue:2 Topics: Aldosterone; Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Cells, Cultured; Cyclic	2007
Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis. Kidney international, 2007, Volume: 71, Issue:5 Topics: Actins; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Biomarkers; Blood Pressure;	2007
Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury. Hypertension research : official journal of the Japanese Society of Hypertension, 2007, Volume: 30, Issue:1 Topics: Aging; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles	2007
Mesangial proliferative glomerulonephritis with aldosterone-producing adenoma. Clinical and experimental nephrology, 2007, Volume: 11, Issue:2 Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Biopsy; Glomerulonephritis, Membranoproliferative; He	2007
Aldosterone receptor antagonism alleviates proteinuria, but not malignant hypertension, in Cyp1a1-Ren2 transgenic rats. American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:5 Topics: Adrenal Glands; Aldosterone; Angiotensin II; Animals; Animals, Genetically Modified; Blood Pressure;	2007
Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia. Kidney international, 2007, Volume: 72, Issue:12 Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Diuretics; Hydrochlorothiazide; Hypertension, Ren	2007
Relation of dietary salt and aldosterone to urinary protein excretion in subjects with resistant hypertension. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:2 Topics: Aged; Aldosterone; Circadian Rhythm; Cohort Studies; Female; Humans; Hypertension; Male; Middle Aged	2008
Experimental hypertensive disease of pregnancy. Obstetrics and gynecology, 1967, Volume: 30, Issue:3 Topics: Aldosterone; Angiography; Animals; Blood Pressure; Dogs; Female; Fetus; Hypertension; Kidney; Matern	1967
Exercise-induced urinary abnormalities in long-distance runners. International journal of sports medicine, 1984, Volume: 5, Issue:5 Topics: Acetylglucosaminidase; Adolescent; Adult; Aldosterone; Electrolytes; Female; gamma-Glutamyltransfera	1984
Aldosterone-stimulating factor is increased in idiopathic hyperaldosteronism. Transactions of the Association of American Physicians, 1984, Volume: 97 Topics: Adult; Aldosterone; Blood Proteins; Female; Glycoproteins; Humans; Hyperaldosteronism; Male; Protein	1984
Renal sodium handling in minimal change nephrotic syndrome. Archives of disease in childhood, 1984, Volume: 59, Issue:9 Topics: Adolescent; Aldosterone; Child; Child, Preschool; Diuresis; Edema; Female; Furosemide; Glomerular Fi	1984
Genetic and pathophysiologic studies of a new kindred with glucocorticoid-suppressible hyperaldosteronism manifest in three generations. The Journal of clinical endocrinology and metabolism, 1981, Volume: 53, Issue:5 Topics: Adult; Aldosterone; Child; Dexamethasone; Female; Genotype; Glycoproteins; HLA Antigens; Humans; Hyp	1981
Plasma renin and aldosterone in adult-onset diabetics with persistent proteinuria. Japanese journal of medicine, 1981, Volume: 20, Issue:3 Topics: Aldosterone; Angiotensin II; Bed Rest; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropat	1981
Volume regulation in children with early relapse of minimal-change nephrosis with or without hypovolaemic symptoms. Lancet (London, England), 1995, Jul-15, Volume: 346, Issue:8968 Topics: Adolescent; Aldosterone; Atrial Natriuretic Factor; Blood Volume; Child; Child, Preschool; Female; G	1995
Angiotensin II local hyperreactivity in the progression of IgA nephropathy. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1993, Volume: 21, Issue:6 Topics: Adult; Aldosterone; Analysis of Variance; Angiotensin II; Captopril; Creatinine; Female; Glomerular	1993
Renovascular hypertension with massive proteinuria. Internal medicine (Tokyo, Japan), 1996, Volume: 35, Issue:7 Topics: Aged; Aldosterone; Female; Humans; Hypertension, Renovascular; Hypokalemia; Kidney; Nephrectomy; Pro	1996
Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats. Hypertension (Dallas, Tex. : 1979), 1999, Volume: 33, Issue:1 Pt 2 Topics: Aldosterone; Animals; Arterioles; Blood Pressure; Captopril; Infusions, Intravenous; Kidney Cortex;	1999
Effect of increased renal venous pressure on renal function. The Journal of trauma, 1999, Volume: 47, Issue:6 Topics: Abdomen; Acute Disease; Acute Kidney Injury; Aldosterone; Animals; Blood Flow Velocity; Compartment	1999
Delayed hypotensive effect of the thromboxane A2/prostaglandin H2 receptor antagonist S-1452 in spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology, 2000, Volume: 27, Issue:8 Topics: 6-Ketoprostaglandin F1 alpha; Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Bridged	2000
Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. Kidney international, 2000, Volume: 58, Issue:3 Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Blotting, Northern; Creatinine; Disease Progre	2000
Effect of angiotensin II blockade on renal injury in mineralocorticoid-salt hypertension. Hypertension (Dallas, Tex. : 1979), 2000, Volume: 36, Issue:4 Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals	2000
The role of nitric oxide and the renin-angiotensin system in salt-restricted Dahl rats. American journal of hypertension, 2001, Volume: 14, Issue:3 Topics: Aldosterone; Animals; Blood Pressure; Diet, Sodium-Restricted; Down-Regulation; Glucuronidase; Hyper	2001
Renal abnormalities in sickle-cell beta-thalassemia. American journal of hematology, 2001, Volume: 66, Issue:1 Topics: Aldosterone; Anemia, Sickle Cell; beta-Thalassemia; Erythropoietin; Humans; Kidney Diseases; Kidney	2001
Proteinuria in renal artery occlusion is related to active renin concentration and contralateral kidney size. Journal of hypertension, 2002, Volume: 20, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Arteriosclerosis; Blood Pressure; Cholesterol; Creatini	2002
Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency. Kidney international, 2002, Volume: 61, Issue:2 Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Bradykin	2002
Hypokalaemia in acute myeloid leukaemia. Annals of internal medicine, 1975, Volume: 82, Issue:1 Topics: Aldosterone; Humans; Hydrocortisone; Hydrogen-Ion Concentration; Hypokalemia; Kidney; Leukemia, Myel	1975
Experimental toxemia of pregnancy in the monkey, with a preliminary report on renin and aldosterone. The American journal of pathology, 1977, Volume: 86, Issue:3 Topics: Aldosterone; Animals; Aorta; Constriction; Disease Models, Animal; Female; Haplorhini; Hypertension;	1977
Corticoid effects on angiotensin- and norepinephrine-induced proteinuria in rats. The American journal of physiology, 1979, Volume: 237, Issue:2 Topics: Aldosterone; Angiotensin II; Animals; Dexamethasone; Female; Inulin; Norepinephrine; p-Aminohippuric	1979
[A nephrologist's thoughts on pregnancy toxemia]. Minerva medica, 1979, Oct-06, Volume: 70, Issue:43 Topics: Aldosterone; Angiotensins; Edema; Female; Glomerular Filtration Rate; Glomerulonephritis; Humans; Hy	1979
Some aspects of urinary kallikrein in a patient with Bartter's syndrome. Advances in experimental medicine and biology, 1979, Volume: 120B Topics: Aldosterone; Angiotensin II; Bartter Syndrome; Female; Humans; Hyperaldosteronism; Indomethacin; Iso	1979
Isolation of a hypertension-producing compound from normal human urine. Circulation research, 1977, Volume: 40, Issue:5 Suppl 1 Topics: Aldosterone; Animals; Blood Pressure; Blood Volume; Heart Rate; Humans; Hypertension; Kidney; Molecu	1977
[A critical review of hypothetical causes of EPH-gestosis]. Zentralblatt fur Gynakologie, 1976, Volume: 98, Issue:18 Topics: Aldosterone; Angiotensin II; Animals; Biogenic Amines; Blood Volume; Body Fluids; Edema; Female; Fib	1976
[Physiopathology and clinical aspects of primary hyperaldosteronism]. Recenti progressi in medicina, 1975, Volume: 59, Issue:6 Topics: Adenoma; Adrenal Cortex Neoplasms; Aldosterone; Humans; Hyperaldosteronism; Hypertension; Proteinuri	1975
Exercise-induced proteinuria is attenuated by indomethacin. Medicine and science in sports and exercise, 1992, Volume: 24, Issue:10 Topics: Adult; Albuminuria; Aldosterone; Captopril; Exercise; Hemodynamics; Humans; Indomethacin; Male; Pros	1992
Angiotensin-converting enzyme (ACE) inhibition. Therapeutic option for diabetic hypertensive patients. Drugs, 1990, Volume: 39 Suppl 2 Topics: Adult; Aldosterone; Diabetes Mellitus, Type 2; Enalapril; Female; Humans; Hypertension; Male; Middle	1990
Effect of lisinopril monotherapy on renal hemodynamics. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1988, Volume: 11, Issue:6 Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Creatinine; Electrolytes; Ena	1988
The relationship of the renin-angiotensin-aldosterone system to atrial natriuretic peptide and the natriuresis of volume expansion in diabetics with and without proteinuria. Postgraduate medical journal, 1988, Volume: 64 Suppl 3 Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Volume; Diabetes Mellitus; Diabetic Nephropathi	1988
Sodium excretion in normal and hypertensive pregnancy: a prospective study. American journal of obstetrics and gynecology, 1988, Volume: 159, Issue:2 Topics: Aldosterone; Cross-Sectional Studies; Diet; Diet, Sodium-Restricted; Female; Humans; Hypertension; I	1988
Plasma renin, renin substrate, angiotensin II, and aldosterone in hypertensive disease of pregnancy. Lancet (London, England), 1973, Feb-10, Volume: 1, Issue:7798 Topics: Aldosterone; Angiotensin II; Blood Pressure; Estrogens; Female; Gestational Age; Humans; Hypertensio	1973
[Renin activity in the blood plasma in pheochromocytoma]. Kardiologiia, 1973, Volume: 13, Issue:4 Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aldosterone; Cardiomegaly; Catecholamines; Chromatograph	1973
Studies on hyperproteinemia and proteinuria in rats bearing a mammosomatotropic tumor. Endocrinology, 1967, Volume: 80, Issue:2 Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Animals; Blood Protein Disorders; Desoxycor	1967
Plasma cortisol and adrenocorticotrophic hormone in normal men and non-pregnant women, normal pregnant women and women with pre-eclampsia. The Journal of obstetrics and gynaecology of the British Commonwealth, 1972, Volume: 79, Issue:6 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aldosterone; Blood; Cesarean Section; Circadian	1972
Angiotensin, aldosterone and DOC in hypertensive disease of pregnancy. Scottish medical journal, 1973, Volume: 18, Issue:2 Topics: Aldosterone; Angiotensin II; Desoxycorticosterone; Female; Humans; Hypertension; Pregnancy; Pregnanc	1973
[Nephrologic aspects of late gestosis (author's transl)]. Zeitschrift fur Geburtshilfe und Perinatologie, 1974, Volume: 178, Issue:2 Topics: Aldosterone; Edema; Female; Hemodynamics; Humans; Hypertension; Kidney Diseases; Pre-Eclampsia; Preg	1974
[Edema]. Saishin igaku. Modern medicine, 1969, Volume: 24, Issue:7 Topics: Aldosterone; Blood Proteins; Body Fluids; Edema; Heart Function Tests; Humans; Kidney Function Tests	1969
[Orthostatic reaction disorders in the etiopathogenesis of various pathologic conditions]. Casopis lekaru ceskych, 1970, Mar-06, Volume: 109, Issue:11 Topics: Addison Disease; Aldosterone; Edema; Hemodynamics; Humans; Hypertension; Hypertension, Renal; Hypote	1970
Renal-adrenal interrelationships in experimental hypertension. Canadian journal of physiology and pharmacology, 1968, Volume: 46, Issue:2 Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Desoxycorticosterone; Female; Hypertension, Renal	1968
[Kidney artery stenosis, renal hypertension and secondary hyperaldosteronism in an 8-year-old boy. (Stunted growth through potassium deficiency)]. Helvetica paediatrica acta, 1968, Volume: 23, Issue:5 Topics: Adrenal Glands; Aldosterone; Child; Dwarfism; Humans; Hyperaldosteronism; Hypertension, Renal; Hypok	1968

aldosterone and Proteinuria