aldosterone and Pregnancy studies

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

Excerpt	Relevance	Reference
"To determine the relationship between endothelin-1 (ET-1), human atrial natriuretic peptide (hANP), plasma-renin activity (PRA) and 24-h urinary excretion of aldosterone (U-Ald) in pregnancy-induced hypertension (PIH)."	9.09	Plasma human atrial natriuretic peptide, endothelin-1, aldosterone and plasma-renin activity in pregnancy-induced hypertension. ( Bogdanovska, SV; Gerasimovska, BD; Lozance, LA; Maleska, VT; Masin-Paneva, J; Zafirovska, KG, 1999)
"The effects of angiotensin II infusion without and with simultaneous infusion of prostaglandin E2 were studied in 25 women in second trimester pregnancy."	9.05	The effect of prostaglandin E2 upon the biochemical response to infused angiotensin II in human pregnancy. ( Broughton Pipkin, F; Hunter, JC; O'Brien, PM; Turner, SR, 1984)
" Plasma renin activity (PRA), the daily urinary excretion of aldosterone (dU-Aldo) and electrolytes were studied before and during dihydralazine therapy (25 mg 3 times daily)."	9.04	The renin-aldosterone system in dihydralazine therapy during hypertensive pregnancy. ( Lammintausta, R, 1978)
"We previously demonstrated that 7-d-old rat pups exposed to hypoxia from birth exhibit ACTH-independent increases in corticosterone associated with an increase in steroidogenic acute regulatory (StAR) and peripheral-type benzodiazepine receptor (PBR) proteins."	7.72	Basal and adrenocorticotropin-stimulated corticosterone in the neonatal rat exposed to hypoxia from birth: modulation by chemical sympathectomy. ( Engeland, WC; Lee, JJ; Oaks, MK; Raff, H; Widmaier, EP, 2004)
"The aim of the study was to determine whether reduced birth weight, adrenal suppression, and lung maturation occur in parallel and are cumulative with increasing courses of betamethasone."	7.70	Repeated use of betamethasone in rabbits: effects of treatment variation on adrenal suppression, pulmonary maturation, and pregnancy outcome. ( Abbott, DH; Bird, IM; Hendricks, SK; Magness, RR; Phernetton, T; Pratt, L, 1999)
"To study the relationship between somatostatin (SS), atrial natriuretic peptide (ANP), beta-endorphin (beta-EP), aldosterone (Aldo) and pregnancy induced hypertension (PIH), blood was collected from 69 cases, including non-pregnant women, normal pregnant women, patients with PIH and their newborns (umbilical arteries) and plasma levels of ANP, SS, beta-EP, Aldo were measured by radioimmunoassay."	7.68	[Relation between somatostatin, atrial natriuretic peptide, beta-endorphin, aldosterone and pregnancy induced hypertension]. ( Dai, LT, 1993)
"Atrial natriuretic factor (ANF) may play a role in the regulation of the changes of blood volume and vascular reactivity during pregnancy and when pregnancy is complicated by hypertension."	7.68	Plasma atrial natriuretic factor levels during normal pregnancy and pregnancy complicated by diabetes mellitus and hypertension. ( Atkinson, AB; McCance, DR; McKnight, JA; Roberts, G; Sheridan, B; Traub, AI, 1990)
"The effects of a low-dose oxytocin infusion on blood pressure during late pregnancy and early puerperium are unclear, and its effects on the renin-aldosterone axis are unknown."	7.67	[Effect of oxytocin on renin activity and aldosterone concentration in plasma as well as blood pressure in late pregnancy and early puerperium]. ( Dyllick, H; Hinrichs, S; Kaulhausen, H; Niesert, S; Oney, T, 1985)
"The responses of plasma renin activity (PRA), plasma bradykinin (BK) and urinary kallikrein like activity (UK) associated with the infusion of angiotensin II (AII) before and after NaCl loading were investigated in pregnancy induced hypertension (PIH)."	7.67	[Studies on the pathophysiology of pregnancy induced hypertension--endocrinological analysis by the method of angiotensin II and NaCl loading]. ( Mochizuki, M; Morikawa, H; Yamasaki, M, 1985)
"Plasma concentrations of arginine vasopressin (AVP), angiotensin II (A II), aldosterone (Aldo), serum osmolality (Sosm), urine volume (V), and free water clearance (CH2O) were determined in the third trimester of pregnancy, and 5 days and 3 months after delivery in pre-eclampsia (group I), in normotensive pregnancy (group II), and in non-pregnant control subjects (group III)."	7.67	The osmoregulatory system and the renin-angiotensin-aldosterone system in pre-eclampsia and normotensive pregnancy. ( Danielsen, H; Johannesen, P; Pedersen, EB; Rasmussen, AB, 1985)
"Plasma renin activity (PRA), plasma aldosterone (PA), blood uric acid (BUA), plasma concentrations of catecholamines (Pcat) and plasma volume (PV) were measured simultaneously in 24 patients with pregnancy-induced hypertension (PIH)."	7.66	Plasma renin activity, blood uric acid and plasma volume in pregnancy-induced hypertension. ( Boulanger, JC; Carayon, A; Coevoet, B; Comoy, E; de Fremont, JF; Demory, JE; Desailly, I; Fievet, P; Pleskov, L; Verhoest, P, 1983)
"Concentrations of unconjugated aldosterone and corticosterone were measured in amniotic fluid (AF) at different stages of pregnancy."	7.66	Aldosterone and corticosterone in amniotic fluid during various stages of pregnancy. ( Blankstein, J; Faiman, C; Fujieda, K; Reyes, FI; Winter, JS, 1980)
"Plasma concentrations of desoxycorticosterone (DOC) and aldosterone are markedly elevated in pregnancy."	7.66	Desoxycorticosterone in normal pregnancy. I. Sequential studies of the secretory patterns of desoxycorticosterone, aldosterone, and cortisol. ( Ehrlich, EN; Lindheimer, MD; Nolten, WE; Oparil, S, 1978)
"Compared with a group of normal pregnant women, matched for age, parity, posture, and length of gestation, women with hypertension and proteinuria in the last trimester had significantly lower plasma concentrations of renin, renin substrate and angiotensin II."	7.65	Studies of the renin-angiotension-aldosterone system, cortisol, DOC, and ADH in normal and hypertensive pregnancy. ( Doig, A; Fraser, R; Morton, JJ; Parboosingh, J; Robertson, JI; Weir, RJ; Wilson, A, 1976)
"The anti-hypertensive effect of spironolactone and thiabutazide was tested on 47 unselected patients with primary hypertension."	7.65	[Spironolactone and thiabutazide in the treatment of essential hypertension (author's transl)]. ( Braun, B; Klaus, D; Klump, F; Lemke, R; Zehner, J; Zöfel, P, 1975)
"In 83 women with preterm labor randomly assigned to ritodrine (N = 42) or terbutaline (N = 41), the maximum decrease in plasma potassium occurred after six hours of drug infusion."	6.68	Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences. ( Braden, GL; Germain, MJ; Haag, BL; von Oeyen, PT; Watson, DJ, 1997)
" Three-point dose-response curves were initially determined for all women."	6.66	The effect of prostaglandin E1 upon the pressor and hormonal response to exogenous angiotensin II in human pregnancy. ( Broughton Pipkin, F; Morrison, R; O'Brien, PM, 1987)
"PGF2 alpha was the same in preeclampsia and normotensive pregnancy but higher than in the non-pregnant group."	6.65	Prostaglandins, renin, aldosterone, and catecholamines in preeclampsia. ( Christensen, NJ; Christensen, P; Johannesen, P; Kornerup, HJ; Kristensen, S; Lauritsen, JG; Leyssac, PP; Pedersen, EB; Rasmussen, AB; Wohlert, M, 1983)
"Preeclampsia is a hypertensive disorder unique to pregnancy and remains the leading cause of maternal and fetal morbidity and mortality."	6.44	Role of aldosterone availability in preeclampsia. ( Escher, G; Mohaupt, M, 2007)
"Diagnosis of primary hyperaldosteronism in pregnancy is complicated due to lack of reference ranges for aldosterone, renin and aldosterone-to-renin ratio."	5.72	Establishing Reference Ranges for Aldosterone, Renin and Aldosterone-to-Renin Ratio for Women in the Third-Trimester of Pregnancy. ( Grzesiak, M; Horzelski, W; Lewandowski, KC; Lewinski, A; Tadros-Zins, M, 2022)
"Preeclampsia is a life-threatening disorder of pregnancy unique to humans."	5.72	Galectin-7 dysregulates renin-angiotensin-aldosterone and NADPH oxide synthase pathways in preeclampsia. ( Dimitriadis, E; Menkhorst, E; Santos, L; St-Pierre, Y; Young, MJ; Zhang, JG; Zhou, W, 2022)
"Aldosterone levels were not associated to preeclampsia incidence."	5.51	Aldosterone, Salt, and Potassium Intakes as Predictors of Pregnancy Outcome, Including Preeclampsia. ( Andersen, LB; Andersen, MS; Birukov, A; Dechend, R; Golic, M; Haase, N; Herse, F; Jensen, BL; Jørgensen, JS; Kitlen, G; Kräker, K; Kyhl, HB; Müller, DN; Rakova, N, 2019)
"Aldosterone is an important factor supporting placental growth and fetal development."	5.43	Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation. ( Albrecht, C; Baumann, M; Currie, G; Delles, C; Dick, B; Eisele, N; Escher, G; Gennari-Moser, C; Mistry, HD; Mohaupt, MG; Surbek, D, 2016)
"We hypothesized that preeclampsia is associated with alterations in the RAAS in the offspring that persist into adolescence."	5.42	The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. ( Brosnihan, KB; Chappell, MC; Diz, DI; Gwathmey, TM; Nixon, PA; O'Shea, TM; Russell, GB; Snively, BM; Washburn, LK, 2015)
"The diagnosis of gestational diabetes mellitus (GDM) and impaired glucose tolerance during pregnancy were made according to the guidelines of the Chinese Society of Obstetrics."	5.38	Renin angiotensin aldosterone system and glycemia in pregnancy. ( Chen, GJ; Chen, YP; Gong, J; Hocher, B; Li, J; Pfab, T; Reichetzeder, C; Wang, ZN; Xiao, XM; Xu, H, 2012)
"However, these values in preeclampsia are decreased to nearly that of a nonpregnant subject, and vascular sensitivity to angiotensin II is increased."	5.35	The relationship between aldosterone to renin ratio and RI value of the uterine artery in the preeclamptic patient vs. normal pregnancy. ( Kim, EH; Kim, YH; Lim, JH; Park, YW, 2008)
"We describe a 26-year-old woman with Bartter's syndrome."	5.32	Maternal Bartter's syndrome in pregnancy treated by amiloride. ( Courouble, N; Deruelle, P; Dufour, P; Magnenant, E; Puech, F, 2004)
"Gestational hypertension is a multisystem disorder which always resolves itself after delivery; its primary pathology still remains incompletely clarified."	5.31	The renin-aldosterone system during normal and hypertensive pregnancy. ( Creatsas, G; Elsheikh, A; Loutradis, D; Mastorakos, G; Michalas, S; Milingos, S, 2001)
"Although primary aldosteronism is rare, especially during pregnancy, it should be always considered as one of etiologies of hypertension in pregnancy."	5.30	Primary aldosteronism with aldosterone-producing adrenal adenoma in a pregnant woman. ( Fujiyama, S; Inada, M; Iwasaka, T; Maruyama, K; Masaki, H; Matsubara, H; Matsuda, T; Mori, Y; Nagata, T; Okada, S; Umeda, Y; Yonemoto, T, 1999)
"After treatment for the heart failure plasma atrial natriuretic peptide fell considerably and there were associated increases in plasma aldosterone and plasma renin activity."	5.28	Atrial natriuretic peptide, aldosterone, and plasma renin activity in peripartum heart failure. ( Adesanya, CO; Anjorin, FI; MacGregor, GA; Parry, EH; Sada, IA; Sagnella, GA, 1991)
"Pregnancy is associated with an increase in blood volume expansion, therefore an increase in ANP-concentration would have been expected."	5.28	[The course of atrial natriuretic peptide, aldosterone and antidiuretic hormone in normal pregnancy]. ( Fitz, R; Havel, M; Huber, JC; Vytiska-Binstorfer, E, 1989)
"Furthermore, in preeclampsia, a particularly low ratio seemed to be typical of the patients who showed poorer placental flows and fetal outcomes."	5.28	Ratio between aldosterone and atrial natriuretic peptide in pregnancy. ( Canavese, C; Fianchino, O; Gagliardi, L; Gurioli, L; Mattone, GC; Porcu, M; Stratta, P; Todros, T; Vercellone, A, 1989)
"The aldosterone levels were significantly greater in umbilical veins and artery than in maternal peripheral veins."	5.28	[Dopaminergic control of aldosterone and prolactin secretion during normal pregnancy and toxemia of pregnancy]. ( Niibe, T, 1989)
"Captopril was given to pregnant and nonpregnant animals during the developmental phase of hypertension and to nonpregnant animals with established (4 weeks of treatment) hypertension."	5.26	Aldosterone-induced hypertension: effects of a kininase inhibitor. ( Douglas, BH; Evans, TA; Lundy, JH; Parks, BR, 1980)
"PGF2 alpha was the same in preeclampsia and normotensive pregnancy but higher than in the non-pregnant group."	5.26	Prostaglandins, catecholamines, renin and aldosterone during hypertensive and normotensive pregnancy. ( Christensen, NJ; Christensen, P; Johannesen, P; Kornerup, HJ; Kristensen, S; Lauritsen, JG; Leyssac, PP; Pedersen, EB; Rasmussen, AB; Wohlert, M, 1982)
"2) PRA and PA in toxemia of pregnancy were obviously lower in comparison with normal pregnancy in the corresponding period."	5.26	[Renin and aldosterone during pregnancy (author's transl)]. ( Mochizuki, M; Motoyama, S; Tojo, S, 1980)
"Experimental toxemia of pregnancy was induced in 8 pregnant monkeys (Macacamulatta) by reducing the abdomiinal aorta to one-third of its original diameter during the last month of gestation."	5.26	Experimental toxemia of pregnancy in the monkey, with a preliminary report on renin and aldosterone. ( Abitbol, MM; Driscoll, SG; Gallo, GR; Ober, MB; Pirani, CL, 1977)
"Aldosterone levels were low or undetectable in adrenal insufficiency and plasma renin levels were grossly elevated in one patient with adrenal insufficiency but within the normal range in the other."	5.26	Plasma renin and aldosterone in pregnancy complicated by adrenal insufficiency. ( Craven, DJ; Symonds, EM, 1977)
"The aim of this study was to assess novel inflammatory markers [adipokines leptin, adiponectin, and leptinadiponectin ratio (L/A)] in overweight women with and without PCOS and to examine alterations in these markers [aldosterone, leptin, adiponectin, and L/A] with pharmacological interventions modulating insulin resistance (IR) in PCOS."	5.14	Novel inflammatory markers in overweight women with and without polycystic ovary syndrome and following pharmacological intervention. ( Hutchison, SK; Meyer, C; Moran, LJ; Teede, HJ; Zoungas, S, 2010)
"To determine the relationship between endothelin-1 (ET-1), human atrial natriuretic peptide (hANP), plasma-renin activity (PRA) and 24-h urinary excretion of aldosterone (U-Ald) in pregnancy-induced hypertension (PIH)."	5.09	Plasma human atrial natriuretic peptide, endothelin-1, aldosterone and plasma-renin activity in pregnancy-induced hypertension. ( Bogdanovska, SV; Gerasimovska, BD; Lozance, LA; Maleska, VT; Masin-Paneva, J; Zafirovska, KG, 1999)
"A double-blind, placebo-controlled study has assessed the maternal and fetal endocrine effects of the maternal administration of the anti-progestin mifepristone in mid-pregnancy."	5.06	The placental transfer of mifepristone (RU 486) during the second trimester and its influence upon maternal and fetal steroid concentrations. ( Ferguson, J; Hill, NC; MacKenzie, IZ; Selinger, M, 1990)
"A double-blind, placebo-controlled trial was conducted to assess the maternal and fetal endocrine effects of epostane, an inhibitor of progesterone synthesis, in mid-pregnancy."	5.06	The effect of epostane, a 3-beta hydroxy steroid dehydrogenase inhibitor, on maternal and fetal steroid levels during mid-gestation. ( Ferguson, J; Gillmer, MD; MacKenzie, IZ; Phipps, SL; Selinger, M, 1988)
" In the prospective study reported here the behavior of plasma renin activity, angiotensin II, aldosterone and cortisol values were therefore investigated in 10 normotensive and 20 hypotensive women during pregnancy."	5.06	[Hypotension in pregnancy, a sequela of adrenal cortex insufficiency?]. ( Goeschen, K; Peters, I; Schneider, J, 1987)
"The effects of angiotensin II infusion without and with simultaneous infusion of prostaglandin E2 were studied in 25 women in second trimester pregnancy."	5.05	The effect of prostaglandin E2 upon the biochemical response to infused angiotensin II in human pregnancy. ( Broughton Pipkin, F; Hunter, JC; O'Brien, PM; Turner, SR, 1984)
" Plasma renin activity (PRA), the daily urinary excretion of aldosterone (dU-Aldo) and electrolytes were studied before and during dihydralazine therapy (25 mg 3 times daily)."	5.04	The renin-aldosterone system in dihydralazine therapy during hypertensive pregnancy. ( Lammintausta, R, 1978)
" We hypothesized that pregnancy would be associated with changes in the relationships between SNA (measured as muscle SNA) and volume-regulating factors, including plasma osmolality, plasma renin activity, and arginine vasopressin (AVP)."	3.85	Muscle sympathetic nerve activity and volume-regulating factors in healthy pregnant and nonpregnant women. ( Chari, RS; Charkoudian, N; Davenport, MH; Davidge, ST; Julian, CG; Khurana, R; Skow, RJ; Staab, JS; Steinback, CD; Stickland, MK; Usselman, CW, 2017)
" There are very little data about the effects of increased angiotensin II (Ang II) concentrations during pregnancy on in utero development of the fetus."	3.85	Prenatal exposure to angiotensin II increases blood pressure and decreases salt sensitivity in rats. ( Krskova, L; Okuliarova, M; Olexova, L; Panakova, Z; Senko, T; Svitok, P; Zeman, M, 2017)
" As an indirect measure of ENaC activity, we compared the natriuretic response to benzamil in offspring of mothers who ate a low-protein diet (6%) with those who ate a normal diet (20%) for the last half of pregnancy."	3.78	Prenatal programming of rat cortical collecting tubule sodium transport. ( Baum, M; Cheng, CJ; Lozano, G, 2012)
" The corticosteroid synthesis inhibitor metyrapone was injected daily during days 14-19 of pregnancy, without (n = 6) and with commensurate administration of cortisol (n = 6)."	3.73	Lack of effect of metyrapone and exogenous cortisol on early porcine conceptus development. ( Christenson, RK; Klemcke, HG; Vallet, JL, 2006)
"We previously demonstrated that 7-d-old rat pups exposed to hypoxia from birth exhibit ACTH-independent increases in corticosterone associated with an increase in steroidogenic acute regulatory (StAR) and peripheral-type benzodiazepine receptor (PBR) proteins."	3.72	Basal and adrenocorticotropin-stimulated corticosterone in the neonatal rat exposed to hypoxia from birth: modulation by chemical sympathectomy. ( Engeland, WC; Lee, JJ; Oaks, MK; Raff, H; Widmaier, EP, 2004)
"The aim of the study was to determine whether reduced birth weight, adrenal suppression, and lung maturation occur in parallel and are cumulative with increasing courses of betamethasone."	3.70	Repeated use of betamethasone in rabbits: effects of treatment variation on adrenal suppression, pulmonary maturation, and pregnancy outcome. ( Abbott, DH; Bird, IM; Hendricks, SK; Magness, RR; Phernetton, T; Pratt, L, 1999)
"The study was carried out to determine the urinary excretion of endothelin-1 (ET-1) in normal pregnancy and to define its possible role in mediating the renal response to aldosterone and arginine vasopressin (AVP)."	3.69	Renal electrolyte and water handling in normal pregnancy: possible role of endothelin-1. ( Rascher, W; Sulyok, E; Tamás, P; Worgall, S, 1994)
"Congenital adrenal hypoplasia is a rare disorder and one of the possible causes of low maternal plasma and/or urine estriol during pregnancy."	3.69	Prenatal diagnosis of congenital adrenal hypoplasia. ( Dörr, HG; Partsch, CJ; Peter, M; Sippell, WG, 1996)
"To study the relationship between somatostatin (SS), atrial natriuretic peptide (ANP), beta-endorphin (beta-EP), aldosterone (Aldo) and pregnancy induced hypertension (PIH), blood was collected from 69 cases, including non-pregnant women, normal pregnant women, patients with PIH and their newborns (umbilical arteries) and plasma levels of ANP, SS, beta-EP, Aldo were measured by radioimmunoassay."	3.68	[Relation between somatostatin, atrial natriuretic peptide, beta-endorphin, aldosterone and pregnancy induced hypertension]. ( Dai, LT, 1993)
"To examine the role of mineralocorticoids in the pathophysiology of pregnancy-induced hypertension (PIH), we studied plasma aldosterone and 18-hydroxycorticosterone levels in 25 women with PIH and 25 normal pregnant women, as controls."	3.68	Mineralocorticoids and mineralocorticoid receptors in mononuclear leukocytes in patients with pregnancy-induced hypertension. ( Bastert, G; Bauer, H; E-Mistry, N; Stolz, W; Vecsei, P; Wacker, J, 1992)
" To determine if changes in receptors for vasoactive peptides could account for these observations, receptor kinetics were measured for Arg8-vasopressin (AVP), angiotensin II (Ang II), and atrial natriuretic peptide (ANP) in the mesenteric vascular bed of the rat throughout pregnancy."	3.68	Receptors for Arg8-vasopressin, angiotensin II, and atrial natriuretic peptide in the mesenteric vasculature of pregnant rats. ( Parent, A; Schiffrin, EL; St-Louis, J, 1991)
"Atrial natriuretic factor (ANF) may play a role in the regulation of the changes of blood volume and vascular reactivity during pregnancy and when pregnancy is complicated by hypertension."	3.68	Plasma atrial natriuretic factor levels during normal pregnancy and pregnancy complicated by diabetes mellitus and hypertension. ( Atkinson, AB; McCance, DR; McKnight, JA; Roberts, G; Sheridan, B; Traub, AI, 1990)
"The hypothesis that pregnancy induced hypertension (PIH) is associated with abnormal physiological control of plasma renin activity (PRA) was tested by studying the effects of graded infusion of angiotensin II (ANG II) on PRA, plasma aldosterone (PA), and blood pressure in normal pregnancy, PIH, non-pregnant women in luteal and follicular phase of the menstrual cycle, and males."	3.67	Failure of angiotensin II to reduce plasma renin activity in hypertensive pregnant women. ( Alcazar, JM; Garcia-Robles, R; Hammond, TG; Knox, FG; Paya, C; Rodicio, J; Romero, JC; Ruilope, L; Sancho-Rof, J, 1984)
"Ammonium glycyrrhizinate (AG), a commercially used salt of glycyrrhizic acid, was administered in the drinking-water to Sprague-Dawley rats on days 7-17 of pregnancy."	3.67	Teratogenicity study of ammonium glycyrrhizinate in the Sprague-Dawley rat. ( Badellino, E; Caiola, S; De Vincenzi, M; Macri, C; Mantovani, A; Patriarca, M; Piccioni, A; Ricciardi, C; Stazi, AV, 1988)
"Plasma aldosterone, corticosterone, and cortisol were measured during the first week of pseudopregnancy or pregnancy in New Zealand White rabbits to determine whether any sustained elevations of adrenal steroids occur."	3.67	Mineralocorticoid concentrations in unstressed female rabbits and embryonic sodium transport. ( Benos, DJ; Biggers, JD; Nielsen, LL, 1987)
" To assess further the relevance of this animal as a model system for toxemia of pregnancy in humans, we characterized the endocrine profile of the patas pregnancy by analyzing weekly blood samples for estrone, estradiol, estriol, progesterone, aldosterone, and PRA throughout gestation."	3.67	Endocrine profile of pregnancy in the patas monkey (Erythrocebus patas). ( Cicmanec, J; Davis, E; Harbaugh, S; Loriaux, DL; Palmer, AE; Winterer, J, 1985)
"The responses of plasma renin activity (PRA), plasma bradykinin (BK) and urinary kallikrein like activity (UK) associated with the infusion of angiotensin II (AII) before and after NaCl loading were investigated in pregnancy induced hypertension (PIH)."	3.67	[Studies on the pathophysiology of pregnancy induced hypertension--endocrinological analysis by the method of angiotensin II and NaCl loading]. ( Mochizuki, M; Morikawa, H; Yamasaki, M, 1985)
"Ovarian hyperstimulation syndrome occurred after induction of ovulation with menotropins (follicle-stimulating hormone and luteinizing hormone) and implantation of an intrauterine pregnancy."	3.67	Pathophysiology of the ovarian hyperstimulation syndrome. ( Haning, RV; Nolten, WE; Strawn, EY, 1985)
"Plasma concentrations of arginine vasopressin (AVP), angiotensin II (A II), aldosterone (Aldo), serum osmolality (Sosm), urine volume (V), and free water clearance (CH2O) were determined in the third trimester of pregnancy, and 5 days and 3 months after delivery in pre-eclampsia (group I), in normotensive pregnancy (group II), and in non-pregnant control subjects (group III)."	3.67	The osmoregulatory system and the renin-angiotensin-aldosterone system in pre-eclampsia and normotensive pregnancy. ( Danielsen, H; Johannesen, P; Pedersen, EB; Rasmussen, AB, 1985)
" Blood pressure was normal during treatment with spironolactone and during pregnancy, when the action of aldosterone and other similar steroids was presumably blocked by an increased production of progesterone; this suggests that the hypertension is dependent upon sodium-retaining steroids such as aldosterone."	3.66	Overproduction of sodium-retaining steroids by the zona glomerulosa is adrenocorticotropin-dependent and mediates hypertension in dexamethasone-suppressible aldosteronism. ( Bartter, FC; Gill, JR, 1981)
"Plasma renin activity (PRA), plasma aldosterone (PA), blood uric acid (BUA), plasma concentrations of catecholamines (Pcat) and plasma volume (PV) were measured simultaneously in 24 patients with pregnancy-induced hypertension (PIH)."	3.66	Plasma renin activity, blood uric acid and plasma volume in pregnancy-induced hypertension. ( Boulanger, JC; Carayon, A; Coevoet, B; Comoy, E; de Fremont, JF; Demory, JE; Desailly, I; Fievet, P; Pleskov, L; Verhoest, P, 1983)
" Hypothyroidism was induced by administration of n-propylthiouracil and hyperthyroidism was induced by injection of T4."	3.66	Weaning in the rat: a study of hormonal influences. ( Blake, HH; Henning, SJ, 1983)
"The role of the renin-angiotensin system in the development of hypertension was studied by infusing an angiotensin II analog, 1-Sar, 8-Ile angiotensin II, in women with toxemia and women on estrogen-containing oral contraceptives or estrogen treatment."	3.66	Effects of angiotensin II analog on blood pressure, renin and aldosterone in women on oral contraceptives and toxemia. ( Kondo, K; Nagahama, S; Nakamura, R; Saruta, T; Suzuki, H, 1981)
" An inhibitor of angiotensin-I-converting enzyme activity (D-3-mercapto-2-methylpropanoyl-L-proline, Captopril) was given to five chronically cannulated pregnant ewes and eleven rabbits in late pregnancy."	3.66	The effect of captopril (SQ14,225) upon mother and fetus in the chronically cannulated ewe and in the pregnant rabbit. ( Broughton Pipkin, F; Symonds, EM; Turner, SR, 1982)
"Plasma renin activity, plasma renin concentration, plasma renin substrate, plasma angiotensin II and plasma aldosterone were measured in 10 true primiparae, normotensive throughout pregnancy, for 4 days after a spontaneous vaginal delivery."	3.66	Changes in the renin-angiotensin-aldosterone system in normotensive primigravidae in the four days after normal spontaneous delivery. ( Broughton Pipkin, F; Jadoul, FA; Lamming, GD, 1982)
" Materials in the organic extract from a pH-1 hydrolysate of pooled pregnancy urine, were located by their ability to bind with aldosterone and tetrahydroaldosterone antisera and exhibited similar chromatographic properties to the radioactive metabolites."	3.66	Characterisation of aldosterone metabolites cross reacting with aldosterone and tetrahydroaldosterone antibodies. ( Biglieri, EG; Haack, D; Honour, JW; Lichtwald, K; Vecsei, P, 1982)
"The concentrations of corticosterone and aldosterone in the plasma and adrenal glands of foetal, newborn and mother mice were estimated during the last 4 days of pregnancy and throughout the perinatal period."	3.66	Perinatal changes in plasma and adrenal corticosterone and aldosterone concentrations in the mouse. ( Dalle, M; Delost, P; Gay, M; Giry, J, 1978)
"Compared with a group of normal pregnant women, matched for age, parity, posture, and length of gestation, women with hypertension and proteinuria in the last trimester had significantly lower plasma concentrations of renin, renin substrate and angiotensin II."	3.65	Studies of the renin-angiotension-aldosterone system, cortisol, DOC, and ADH in normal and hypertensive pregnancy. ( Doig, A; Fraser, R; Morton, JJ; Parboosingh, J; Robertson, JI; Weir, RJ; Wilson, A, 1976)
"The anti-hypertensive effect of spironolactone and thiabutazide was tested on 47 unselected patients with primary hypertension."	3.65	[Spironolactone and thiabutazide in the treatment of essential hypertension (author's transl)]. ( Braun, B; Klaus, D; Klump, F; Lemke, R; Zehner, J; Zöfel, P, 1975)
"Primary aldosteronism can be regulated by the ectopic expression of G-protein coupled receptors in aldosteronomas or bilateral hyperplasias."	3.01	HCG-responsive aldosteronoma with transient secretion during pregnancy confirmed through HCG-stimulated adrenal venous sampling. ( Castinetti, F; Guerin, C; Lacroix, A; Louiset, E, 2023)
"Emerging antenatal risk factors such as preeclampsia appear to increase the risk of hypertension and cardiovascular disease across the life course in both the offspring and women after pregnancy."	3.01	Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American ( Alexander, BT; August, P; Bertagnolli, M; Ferranti, EP; Grobe, JL; Jones, EJ; Loria, AS; Safdar, B; Sequeira-Lopez, MLS; South, AM, 2023)
"Superimposed preeclampsia complicates about 20% of pregnancies in women with chronic hypertension and is associated with increased maternal and perinatal morbidity compared with preeclampsia alone."	2.82	Chronic hypertension and superimposed preeclampsia: screening and diagnosis. ( Kametas, NA; Nicolaides, KH; Nzelu, D, 2022)
"Primary aldosteronism (PA) in pregnancy (PAP) can be a serious condition and is challenging to diagnose."	2.82	Management and Outcomes of Primary Aldosteronism in Pregnancy: A Systematic Review. ( Rossi, GP; Rossitto, G; Sanga, V; Seccia, TM, 2022)
"In 83 women with preterm labor randomly assigned to ritodrine (N = 42) or terbutaline (N = 41), the maximum decrease in plasma potassium occurred after six hours of drug infusion."	2.68	Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences. ( Braden, GL; Germain, MJ; Haag, BL; von Oeyen, PT; Watson, DJ, 1997)
" When the definition of adverse pregnancy outcome was restricted to fetal death alone (four of 13) the difference remained significant (p < 0."	2.67	Fetotoxicity of angiotensin-converting enzyme inhibition in primate pregnancy: a prospective, placebo-controlled study in baboons (Papio hamadryas). ( Duggin, GG; Harewood, WJ; Horvath, JS; Phippard, AF; Tiller, DJ, 1994)
"Primary aldosteronism (PA) is the most common form of endocrine hypertension."	2.66	Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism. ( Gong, S; Meyer, LS; Reincke, M; Williams, TA, 2020)
" Three-point dose-response curves were initially determined for all women."	2.66	The effect of prostaglandin E1 upon the pressor and hormonal response to exogenous angiotensin II in human pregnancy. ( Broughton Pipkin, F; Morrison, R; O'Brien, PM, 1987)
"PGF2 alpha was the same in preeclampsia and normotensive pregnancy but higher than in the non-pregnant group."	2.65	Prostaglandins, renin, aldosterone, and catecholamines in preeclampsia. ( Christensen, NJ; Christensen, P; Johannesen, P; Kornerup, HJ; Kristensen, S; Lauritsen, JG; Leyssac, PP; Pedersen, EB; Rasmussen, AB; Wohlert, M, 1983)
"Mycophenolic acid was detected in all cats."	2.61	( Abrams, G; Adolfsson, E; Agarwal, PK; Akkan, AG; Al Alhareth, NS; Alves, VGL; Armentano, R; Bahroos, E; Baig, M; Baldridge, KK; Barman, S; Bartolucci, C; Basit, A; Bertoli, SV; Bian, L; Bigatti, G; Bobenko, AI; Boix, PP; Bokulic, T; Bolink, HJ; Borowiec, J; Bulski, W; Burciaga, J; Butt, NS; Cai, AL; Campos, AM; Cao, G; Cao, Y; Čapo, I; Caruso, ML; Chao, CT; Cheatum, CM; Chelminski, K; Chen, AJW; Chen, C; Chen, CH; Chen, D; Chen, G; Chen, H; Chen, LH; Chen, R; Chen, RX; Chen, X; Cherdtrakulkiat, R; Chirvony, VS; Cho, JG; Chu, K; Ciurlino, D; Coletta, S; Contaldo, G; Crispi, F; Cui, JF; D'Esposito, M; de Biase, S; Demir, B; Deng, W; Deng, Z; Di Pinto, F; Domenech-Ximenos, B; Dong, G; Drácz, L; Du, XJ; Duan, LJ; Duan, Y; Ekendahl, D; Fan, W; Fang, L; Feng, C; Followill, DS; Foreman, SC; Fortunato, G; Frew, R; Fu, M; Gaál, V; Ganzevoort, W; Gao, DM; Gao, X; Gao, ZW; Garcia-Alvarez, A; Garza, MS; Gauthier, L; Gazzaz, ZJ; Ge, RS; Geng, Y; Genovesi, S; Geoffroy, V; Georg, D; Gigli, GL; Gong, J; Gong, Q; Groeneveld, J; Guerra, V; Guo, Q; Guo, X; Güttinger, R; Guyo, U; Haldar, J; Han, DS; Han, S; Hao, W; Hayman, A; He, D; Heidari, A; Heller, S; Ho, CT; Ho, SL; Hong, SN; Hou, YJ; Hu, D; Hu, X; Hu, ZY; Huang, JW; Huang, KC; Huang, Q; Huang, T; Hwang, JK; Izewska, J; Jablonski, CL; Jameel, T; Jeong, HK; Ji, J; Jia, Z; Jiang, W; Jiang, Y; Kalumpha, M; Kang, JH; Kazantsev, P; Kazemier, BM; Kebede, B; Khan, SA; Kiss, J; Kohen, A; Kolbenheyer, E; Konai, MM; Koniarova, I; Kornblith, E; Krawetz, RJ; Kreouzis, T; Kry, SF; Laepple, T; Lalošević, D; Lan, Y; Lawung, R; Lechner, W; Lee, KH; Lee, YH; Leonard, C; Li, C; Li, CF; Li, CM; Li, F; Li, J; Li, L; Li, S; Li, X; Li, Y; Li, YB; Li, Z; Liang, C; Lin, J; Lin, XH; Ling, M; Link, TM; Liu, HH; Liu, J; Liu, M; Liu, W; Liu, YP; Lou, H; Lu, G; Lu, M; Lun, SM; Ma, Z; Mackensen, A; Majumdar, S; Martineau, C; Martínez-Pastor, JP; McQuaid, JR; Mehrabian, H; Meng, Y; Miao, T; Miljković, D; Mo, J; Mohamed, HSH; Mohtadi, M; Mol, BWJ; Moosavi, L; Mosdósi, B; Nabu, S; Nava, E; Ni, L; Novakovic-Agopian, T; Nyamunda, BC; Nyul, Z; Önal, B; Özen, D; Özyazgan, S; Pajkrt, E; Palazon, F; Park, HW; Patai, Á; Patai, ÁV; Patzke, GR; Payette, G; Pedoia, V; Peelen, MJCS; Pellitteri, G; Peng, J; Perea, RJ; Pérez-Del-Rey, D; Popović, DJ; Popović, JK; Popović, KJ; Posecion, L; Povall, J; Prachayasittikul, S; Prachayasittikul, V; Prat-González, S; Qi, B; Qu, B; Rakshit, S; Ravelli, ACJ; Ren, ZG; Rivera, SM; Salo, P; Samaddar, S; Samper, JLA; Samy El Gendy, NM; Schmitt, N; Sekerbayev, KS; Sepúlveda-Martínez, Á; Sessolo, M; Severi, S; Sha, Y; Shen, FF; Shen, X; Shen, Y; Singh, P; Sinthupoom, N; Siri, S; Sitges, M; Slovak, JE; Solymosi, N; Song, H; Song, J; Song, M; Spingler, B; Stewart, I; Su, BL; Su, JF; Suming, L; Sun, JX; Tantimavanich, S; Tashkandi, JM; Taurbayev, TI; Tedgren, AC; Tenhunen, M; Thwaites, DI; Tibrewala, R; Tomsejm, M; Triana, CA; Vakira, FM; Valdez, M; Valente, M; Valentini, AM; Van de Winckel, A; van der Lee, R; Varga, F; Varga, M; Villarino, NF; Villemur, R; Vinatha, SP; Vincenti, A; Voskamp, BJ; Wang, B; Wang, C; Wang, H; Wang, HT; Wang, J; Wang, M; Wang, N; Wang, NC; Wang, Q; Wang, S; Wang, X; Wang, Y; Wang, Z; Wen, N; Wesolowska, P; Willis, M; Wu, C; Wu, D; Wu, L; Wu, X; Wu, Z; Xia, JM; Xia, X; Xia, Y; Xiao, J; Xiao, Y; Xie, CL; Xie, LM; Xie, S; Xing, Z; Xu, C; Xu, J; Yan, D; Yan, K; Yang, S; Yang, X; Yang, XW; Ye, M; Yin, Z; Yoon, N; Yoon, Y; Yu, H; Yu, K; Yu, ZY; Zhang, B; Zhang, GY; Zhang, H; Zhang, J; Zhang, M; Zhang, Q; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhang, YW; Zhang, Z; Zhao, D; Zhao, F; Zhao, P; Zhao, W; Zhao, Z; Zheng, C; Zhi, D; Zhou, C; Zhou, FY; Zhu, D; Zhu, J; Zhu, Q; Zinyama, NP; Zou, M; Zou, Z, 2019)
"Hypertension is one of the most common cardiovascular diseases during pregnancy."	2.52	[Hypertension in the course of primary aldosteronism during pregnancy]. ( Chudek, J; Maruniak-Chudek, I; Olszanecka-Glinianowicz, M; Sikora, J; Wyskida, K; Wyskida, M, 2015)
"Aldosterone is a key regulator of electrolyte and water homeostasis and plays a central role in blood pressure regulation."	2.45	Hyperaldosteronism in pregnancy. ( Escher, G, 2009)
"Preeclampsia is a hypertensive disorder unique to pregnancy and remains the leading cause of maternal and fetal morbidity and mortality."	2.44	Role of aldosterone availability in preeclampsia. ( Escher, G; Mohaupt, M, 2007)
"Conditions of secondary aldosteronism are common in clinical medicine, occurring in normotensive and hypertensive settings."	2.39	Secondary aldosteronism. ( Corry, DB; Tuck, ML, 1995)
"In all six cases, severe hydramnios occurred during pregnancy between the 26th and 28th week after the last menstrual period."	2.38	[Antenatal form of Bartter's syndrome]. ( Broyer, M; Burguet, A; Dechaux, M; Deschenes, G; Garabedian, M; Guyot, C; Hubert, P; Loirat, C, 1993)
"Women exposed to preeclampsia have a substantially increased risk of hypertension after pregnancy, but the mechanism remains unknown, leaving a missed interventional opportunity."	1.91	Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia. ( Biwer, LA; Camarda, ND; Carvajal, BV; Ibarrola, J; Jaffe, IZ; Karumanchi, SA; Lu, Q; Man, JJ; Seely, EW; Skurnik, G; Stepanian, A; Zsengeller, Z, 2023)
"Aldosterone was associated inversely with urine sodium/creatinine (β: -0."	1.72	Correlation between kidney sodium and potassium handling and the renin-angiotensin-aldosterone system in children with hypertensive disorders. ( Perrin, EC; South, AM, 2022)
"Diagnosis of primary hyperaldosteronism in pregnancy is complicated due to lack of reference ranges for aldosterone, renin and aldosterone-to-renin ratio."	1.72	Establishing Reference Ranges for Aldosterone, Renin and Aldosterone-to-Renin Ratio for Women in the Third-Trimester of Pregnancy. ( Grzesiak, M; Horzelski, W; Lewandowski, KC; Lewinski, A; Tadros-Zins, M, 2022)
"Preeclampsia is a life-threatening disorder of pregnancy unique to humans."	1.72	Galectin-7 dysregulates renin-angiotensin-aldosterone and NADPH oxide synthase pathways in preeclampsia. ( Dimitriadis, E; Menkhorst, E; Santos, L; St-Pierre, Y; Young, MJ; Zhang, JG; Zhou, W, 2022)
"Normal pregnancy is associated with a rise in aldosterone and renin levels early in pregnancy making the aldosterone:renin ratio which is normally used to screen for primary aldosteronism, difficult to interpret."	1.62	Screening for primary aldosteronism in pregnancy. ( Kumar, S; Morton, A; Vidyasagar, S, 2021)
"Bartter syndrome is an autosomal recessive disorder manifested by a defect in sodium-potassium-chloride transport in the thick ascending limb of Henle with different genetic origins and molecular pathophysiology."	1.56	Antenatal Bartter Syndrome: A Case Report. ( Akther, M; Dey, SK; Jahan, I; Mannan, MA; Moni, SC; Shabuj, KH; Shahidullah, M, 2020)
"The pathophysiology of preeclampsia (PE) remains unclear."	1.56	An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction. ( Chan, HC; Chen, H; Guo, M; Huang, H; Jin, L; Lin, X; Liu, X; Rahman, TU; Ruan, Y; Sheng, J; Tang, L; Ullah, K; Wang, Y; Wu, D; Wu, Y; Xu, G; Yu, P; Yu, Y; Zhou, C, 2020)
"Aldosterone levels were not associated to preeclampsia incidence."	1.51	Aldosterone, Salt, and Potassium Intakes as Predictors of Pregnancy Outcome, Including Preeclampsia. ( Andersen, LB; Andersen, MS; Birukov, A; Dechend, R; Golic, M; Haase, N; Herse, F; Jensen, BL; Jørgensen, JS; Kitlen, G; Kräker, K; Kyhl, HB; Müller, DN; Rakova, N, 2019)
"Bartter syndrome is a severe inherited tubulopathy characterized at birth by salt wasting, severe polyuria, dehydration, growth retardation and secondary hyperaldosteronism."	1.46	Prenatal diagnosis of Bartter syndrome: amniotic fluid aldosterone. ( Chevenne, D; Czerkiewicz, I; Deschênes, G; Dreux, S; Muller, F; Oury, JF; Pean de Ponfilly, G; Rachid, M; Vargas-Poussou, R, 2017)
"Bartter syndrome is a severe inherited tubulopathy characterized by postnatal salt wasting, severe polyuria, dehydration, failure to thrive and secondary hyperaldosteronism."	1.43	Prenatal diagnosis of Bartter syndrome: amniotic fluid aldosterone. ( Chevenne, D; Czerkiewicz, I; Deschênes, G; Dreux, S; Muller, F; Oury, JF; Pean de Ponfilly, G; Rachid, ML; Vargas-Poussou, R, 2016)
"We hypothesized that preeclampsia is associated with low prostasin expression in placenta and spillover of prostasin into urine across the defect glomerular barrier."	1.43	Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women. ( Andersen, LB; Frederiksen-Møller, B; Hansen, MR; Jensen, BL; Jørgensen, JS; Krigslund, O; Vogel, LK, 2016)
"We describe the clinical course of renal tubular acidosis (RTA) type 4 in pregnancy, which has not been previously published."	1.43	Renal tubular acidosis type 4 in pregnancy. ( Baynes, K; Jakes, AD; Nelson-Piercy, C, 2016)
"Aldosterone is an important factor supporting placental growth and fetal development."	1.43	Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation. ( Albrecht, C; Baumann, M; Currie, G; Delles, C; Dick, B; Eisele, N; Escher, G; Gennari-Moser, C; Mistry, HD; Mohaupt, MG; Surbek, D, 2016)
"The mechanism of hyperadrenalism includes the primary activation of the adrenal gland and the conversion of inactive glucocorticoids to active glucocorticoids by 11β-HSD1."	1.43	Nonylphenol-induced hyperadrenalism can be reversed/alleviated by inhibiting of 11-β hydroxysteroid dehydrogenase type 1. ( Chang, LL; Wang, PS; Wun, WS, 2016)
"NOVEL INSIGHT: Antenatal Bartter syndrome is a heterogeneous group of renal disorders."	1.43	Diagnosis of antenatal Bartter syndrome. ( Kesby, G; Narayan, R; Peres, M, 2016)
"We hypothesized that preeclampsia is associated with alterations in the RAAS in the offspring that persist into adolescence."	1.42	The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. ( Brosnihan, KB; Chappell, MC; Diz, DI; Gwathmey, TM; Nixon, PA; O'Shea, TM; Russell, GB; Snively, BM; Washburn, LK, 2015)
"low aldosterone levels) have been found in preeclamptic women, we hypothesized that Asians have lower muscle sympathetic nerve activity (MSNA) and greater aldosterone concentrations during normal pregnancy than Caucasians."	1.42	Asian women have attenuated sympathetic activation but enhanced renal-adrenal responses during pregnancy compared to Caucasian women. ( Best, SA; Casey, BM; Fu, Q; Jarvis, SS; Levine, BD; Okada, Y; Parker, RS; Shibata, S, 2015)
"Pregnancy is characterized by plasma volume expansion due to Na(+) retention, driven by aldosterone."	1.42	Renal NCC is unchanged in the midpregnant rat and decreased in the late pregnant rat despite avid renal Na+ retention. ( Baylis, C; Masilamani, SM; McDonough, AA; Verlander, JW; West, CA, 2015)
"Here we describe three women with hyperaldosteronism, two who presented in pregnancy and one who presented after menopause."	1.42	Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations. ( Azizan, EA; Bienz, M; Brown, MJ; Garg, S; Gurnell, M; Happerfield, L; Karet Frankl, FE; Marker, A; Shaikh, LH; Teo, AE; Zhou, J, 2015)
"Hypocalcemia is a complication that must be monitored when a treatment with high doses of intravenous magnesium sulphate is introduced."	1.40	[Electrolyte disorders in preeclampsia. A case report]. ( Bodenmann Gobin, P; Ducry, J; Gobin, N; Portmann, L; Vial, Y; Vogt, B, 2014)
"Primary hypoaldosteronism without concurrent hypoadrenocorticism was diagnosed in an 8-year-old female alpaca with acute onset of weakness progressing to recumbency within 6 hours after onset."	1.38	Diagnosis and management of hypoaldosteronism without hypoadrenocorticism in an alpaca. ( Barton, MH; Butterworth, KA; Pellegrini-Masini, AM, 2012)
"The diagnosis of gestational diabetes mellitus (GDM) and impaired glucose tolerance during pregnancy were made according to the guidelines of the Chinese Society of Obstetrics."	1.38	Renin angiotensin aldosterone system and glycemia in pregnancy. ( Chen, GJ; Chen, YP; Gong, J; Hocher, B; Li, J; Pfab, T; Reichetzeder, C; Wang, ZN; Xiao, XM; Xu, H, 2012)
"It was hypothesized that preeclampsia is associated with plasmin-dependent ability of tubular fluid to activate ENaC."	1.38	Urinary plasmin activates collecting duct ENaC current in preeclampsia. ( Bistrup, C; Buhl, KB; Frederiksen-Møller, B; Friis, UG; Gulaveerasingam, A; Jensen, BL; Jespersen, B; Ovesen, P; Svenningsen, P, 2012)
"Aldosterone acts as a growth factor in many tissues, whereas cortisol inhibits growth."	1.37	Regulation of placental growth by aldosterone and cortisol. ( Baumann, MU; Escher, G; Frey, BM; Frey, FJ; Gennari-Moser, C; Karumanchi, SA; Khankin, EV; Lehmann, AD; Mohaupt, MG; Portmann, CB; Schüller, S; Surbek, D, 2011)
"Pregnancy is typically paralleled by substantial increase in maternal extracellular fluid volume, requiring net accumulation of water and NaCl."	1.37	SGK1-dependent salt appetite in pregnant mice. ( Artunc, F; Brosens, JJ; Föller, M; Lang, F; Pathare, G; Umbach, AT, 2011)
"However, these values in preeclampsia are decreased to nearly that of a nonpregnant subject, and vascular sensitivity to angiotensin II is increased."	1.35	The relationship between aldosterone to renin ratio and RI value of the uterine artery in the preeclamptic patient vs. normal pregnancy. ( Kim, EH; Kim, YH; Lim, JH; Park, YW, 2008)
"Pregnant women with preeclampsia have increased serotonin levels, suggesting a possible role of this amine in abnormal pregnancy."	1.34	Pregnant rats treated with a serotonin precursor have reduced fetal weight and lower plasma volume and kallikrein levels. ( Aranda, E; Downey, P; Giacaman, A; Mezzano, D; Romero, W; Salas, SP; Vío, CP, 2007)
"Adult hypertension was induced by maternal low-protein diet during the second half of gestation."	1.33	Postnatal modulation of prenatally programmed hypertension by dietary Na and ACE inhibition. ( Manning, J; Vehaskari, VM, 2005)
"Diabetic pregnancy is associated with lower levels of PRA and ANP compared to non-diabetic pregnancy."	1.33	Vasoactive mediators and retinopathy during type 1 diabetic pregnancy. ( Hiilesmaa, VK; Immonen, IJ; Kaaja, RJ; Loukovaara, S; Nicholls, G; Yandle, TG, 2005)
"Despite advances in treatment, twin-to-twin transfusion syndrome (TTTS) still carries a high risk for perinatal mortality and morbidity."	1.33	Paradoxic activation of the renin-angiotensin system in twin-twin transfusion syndrome: an explanation for cardiovascular disturbances in the recipient. ( Delezoide, AL; Dommergues, M; Fisk, NM; Gubler, MC; Madelenat, P; Mahieu-Caputo, D; Martinovic, J; Meulemans, A; Muller, F, 2005)
"Aldosterone values were lower in PE from week 26 to 29 onwards and in FGR after week 34."	1.33	Time course of maternal plasma volume and hormonal changes in women with preeclampsia or fetal growth restriction. ( Gutiérrez, BL; Marshall, G; Rosso, P; Salas, SP, 2006)
"Normal pregnancy is a state of hypercortisolism, making adrenal insufficiency difficult to diagnose."	1.33	Assessment of adrenal reserve in pregnancy: defining the normal response to the adrenocorticotropin stimulation test. ( Hibbard, JU; Kasza, K; Moran, J; Suri, D; Weiss, RE, 2006)
"In preeclamptic patients without intrauterine growth retardation (IUGR) the mean histological index H score was significantly higher, but significantly decreased in patients with preeclampsia complicated by IUGR in comparison with the control group."	1.32	Comparative analysis of the angiotensin-II receptor in placental vascular endothelial cells in preeclamptic and normotensive patients. ( Laskowska, K; Laskowska, M; Leszczyńska-Gorzelak, B; Oleszczuk, J; Szumiło, J; Vinson, GP, 2003)
"We describe a 26-year-old woman with Bartter's syndrome."	1.32	Maternal Bartter's syndrome in pregnancy treated by amiloride. ( Courouble, N; Deruelle, P; Dufour, P; Magnenant, E; Puech, F, 2004)
"Although pregnancy was accompanied by significant increases in plasma aldosterone levels, no interbreed differences were observed, which remained the case postpartum."	1.31	Corticosteroid dynamics in the nonpregnant, pregnant, and postpartum spontaneously hypertensive rat. ( Malee, MP; Wu, KY, 2000)
"Comparison of pregnant patients with preeclampsia versus both normotensive pregnant women and nonpregnant women showed significant increases in left ventricular mass and left ventricular endsystolic and end-diastolic volumes and significant reductions in left ventricular ejection fraction and percentage of fractional shortening."	1.31	Relationship of systemic hemodynamics, left ventricular structure and function, and plasma natriuretic peptide concentrations during pregnancy complicated by preeclampsia. ( Ambrosioni, E; Borghi, C; Boschi, S; Bovicelli, L; Cassani, A; Esposti, DD; Immordino, V, 2000)
"A rat model of intrauterine growth retardation was employed."	1.31	Prenatal programming of adult hypertension in the rat. ( Aviles, DH; Manning, J; Vehaskari, VM, 2001)
"Gestational hypertension is a multisystem disorder which always resolves itself after delivery; its primary pathology still remains incompletely clarified."	1.31	The renin-aldosterone system during normal and hypertensive pregnancy. ( Creatsas, G; Elsheikh, A; Loutradis, D; Mastorakos, G; Michalas, S; Milingos, S, 2001)
"A 24-year-old Japanese woman with IgA nephropathy exhibited a decreased serum aldosterone level with normal plasma renin activity after toxemia of pregnancy."	1.31	Selective hypoaldosteronism due to combined defects of the conversion from inactive renin to active renin and the aldosterone biosynthesis from corticosterone. ( Akai, Y; Asano, Y; Kusano, E; Muto, S; Ono, S, 2001)
"Primary aldosteronism rarely complicates pregnancy."	1.31	Diagnosis and management of primary aldosteronism in pregnancy: case report and review of the literature. ( Asano, K; Fujimori, K; Hashimoto, T; Okawa, T; Sato, A; Yanagida, K, 2002)
"Glucocorticoid remediable hyperaldosteronism (GRA) is a monogenic form of inherited hypertension caused by a chimeric gene originating from an unequal cross-over between the 11 beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes."	1.31	Glucocorticoid remediable aldosteronism: low morbidity and mortality in a four-generation italian pedigree. ( Chiandussi, L; di Cella, SM; Gomez-Sanchez, CE; Mengozzi, G; Milan, A; Mulatero, P; Veglio, F; Williams, TA, 2002)
" BAY K 8644 produced a larger increase in sensitivity in adrenal capsule preparations from pregnant than from nonpregnant rats, leading to superposition of the two dose-response curves to K+."	1.30	Effects of dihydropyridines on aldosterone secretion in adrenal capsule preparations from pregnant rats. ( Brochu, M; Jodoin, S; Picard, S; St-Louis, J, 1997)
"Although primary aldosteronism is rare, especially during pregnancy, it should be always considered as one of etiologies of hypertension in pregnancy."	1.30	Primary aldosteronism with aldosterone-producing adrenal adenoma in a pregnant woman. ( Fujiyama, S; Inada, M; Iwasaka, T; Maruyama, K; Masaki, H; Matsubara, H; Matsuda, T; Mori, Y; Nagata, T; Okada, S; Umeda, Y; Yonemoto, T, 1999)
" Thereafter, the dosage of cortisol was reduced to induce plasma values similar to normal late-gestation cortisol concentration in ewes (1 mg/kg per day), or to values in nonpregnant ewes (0."	1.30	Sheep model for study of maternal adrenal gland function during pregnancy. ( Caldwell, SM; Cudd, TA; Keller-Wood, M; Norman, W; Wood, CE, 1998)
"Bartter syndrome is characterized by renal potassium and chloride loss, hypokalaemia, hypochloraemic metabolic alkalosis and increased plasma renin activity along with elevated angiotensin II and hyperaldosteronism."	1.30	Biochemical examination of mother's urine is useful for prenatal diagnosis of Bartter syndrome. ( Kajiura, S; Matsushita, Y; Okajima, K; Oya, N; Suzuki, Y; Suzumori, K; Uemura, O, 1999)
"The patients were nine women with mild preeclampsia and, for comparison, nine control women matched for gestation and parity."	1.30	Blood pressure and vasoactive hormones in mild preeclampsia and normal pregnancy. ( Frampton, CM; Kaaja, RJ; Moore, MP; Nicholls, MG; Yandle, TG; Ylikorkala, O, 1999)
"Animal models for preeclampsia are no alternative to clinical studies, but they are furthering our understanding of pathophysiology in many fields."	1.30	[Animal experiment models of hypertension in pregnancy--an alternative to clinical studies?]. ( Casper, F; Hropot, M; Leiser, R; Seufert, R, 1999)
"Preeclampsia is accompanied by amplification of the sodium retention that is a feature of normal pregnancy."	1.29	11 beta-Hydroxysteroid dehydrogenase and its inhibitors in hypertensive pregnancy. ( Brown, MA; Edwards, CR; Honour, JW; Walker, BR; Whitworth, JA; Williamson, PM, 1995)
"It is thus suggested that polyhydramnios is the result of increased fetal urine output in Bartter syndrome and that amniotic fluid aldosterone is a reliable marker for the prenatal diagnosis of this condition."	1.29	Prenatal diagnosis of Bartter syndrome. ( Carmi, R; Meizner, I; Ohaly, M; Shalev, H, 1994)
"Aldosterone concentration was measured in umbilical venous blood obtained by funipuncture from pregnancies complicated by red blood cell isoimmunization (n = 17), fetal growth retardation (n = 8), and nonimmune hydrops fetalis (n = 17)."	1.29	Aldosterone concentration in normal, growth-retarded, anemic, and hydropic fetuses. ( Kuhn, P; Nicolaides, KH; Proudler, A; Ville, Y, 1994)
"Prenatal diagnosis of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency by amniotic fluid (AF) steroid analysis is not possible in those cases in which prenatal dexamethasone (DEX) therapy is initiated to prevent virilization of female CAH fetuses because AF steroid levels are suppressed if DEX therapy is continued beyond amniocentesis (AC)."	1.29	Prenatal dexamethasone treatment in pregnancies at risk for congenital adrenal hyperplasia due to 21-hydroxylase deficiency: effect on midgestational amniotic fluid steroid levels. ( Dörr, HG; Sippell, WG, 1993)
" The dose-response curves of ACTH were not significantly different between pregnant and nonpregnant animals."	1.29	Increase of aldosterone secretion in adrenal cortex suspensions derived from pregnant rats. ( Brochu, M; Gauvin, JP; St-Louis, J, 1996)
"Primary hyperaldosteronism is an uncommon disorder, and there are few reports of its occurrence and management in pregnancy."	1.29	Primary hyperaldosteronism in pregnancy. A case report. ( Moore, F; Seely, EW; Solomon, CG; Thiet, M, 1996)
"After treatment for the heart failure plasma atrial natriuretic peptide fell considerably and there were associated increases in plasma aldosterone and plasma renin activity."	1.28	Atrial natriuretic peptide, aldosterone, and plasma renin activity in peripartum heart failure. ( Adesanya, CO; Anjorin, FI; MacGregor, GA; Parry, EH; Sada, IA; Sagnella, GA, 1991)
"Pregnancy is associated with an increase in blood volume expansion, therefore an increase in ANP-concentration would have been expected."	1.28	[The course of atrial natriuretic peptide, aldosterone and antidiuretic hormone in normal pregnancy]. ( Fitz, R; Havel, M; Huber, JC; Vytiska-Binstorfer, E, 1989)
"Furthermore, in preeclampsia, a particularly low ratio seemed to be typical of the patients who showed poorer placental flows and fetal outcomes."	1.28	Ratio between aldosterone and atrial natriuretic peptide in pregnancy. ( Canavese, C; Fianchino, O; Gagliardi, L; Gurioli, L; Mattone, GC; Porcu, M; Stratta, P; Todros, T; Vercellone, A, 1989)
"Six pregnant women (below 49 days of amenorrhea) desiring pregnancy termination received 600 mg RU486 orally in a single dosage and 1 mg PG-05 or ONO-802 as vaginal suppository 48 h afterward."	1.28	Functional status of the pituitary-adrenal axis during treatment of RU486 for termination of early pregnancy in combination with PGs in Chinese women. ( Wu, XR; Yang, XL, 1989)
"The aldosterone levels were significantly greater in umbilical veins and artery than in maternal peripheral veins."	1.28	[Dopaminergic control of aldosterone and prolactin secretion during normal pregnancy and toxemia of pregnancy]. ( Niibe, T, 1989)
"In all groups of fetuses, hypoxemia was associated with a significant increase in plasma K+ concentration (+0."	1.27	Factors controlling aldosterone secretion during hypoxemia in fetal lambs. ( Ayres, NA; Gomez, RA; Nakamura, KT; Robillard, JE; Smith, FG, 1984)
" The slopes of the two dose-response curves were very similar (-14."	1.27	The effect of saralasin in the chronically cannulated ewe in the early puerperium. ( Broughton Pipkin, F; Turner, SR; Wallace, C, 1984)
"A definite diagnosis of primary aldosteronism cannot be made during toxemia of pregnancy, and it is necessary to do serial determinations of plasma renin activity and plasma aldosterone concentration after delivery to confirm the diagnosis."	1.27	Elevation of plasma renin activity during pregnancy and rupture of a dissecting aortic aneurysm in a patient with primary aldosteronism. ( Akahoshi, M; Aoi, W; Doi, Y; Hashiba, K; Kuramochi, M; Shimizu, A; Suzuki, S; Utsunomiya, T, 1983)
"The most common causes of virilization are considered unlikely on the basis of clinical and laboratory data."	1.27	Aldosteronism in pregnancy: association with virilization of female offspring. ( Elterman, JJ; Hagen, GA, 1983)
"In cases of severe preeclampsia, levels of atrial natriuretic peptide were significantly higher than in the other subjects, but aldosterone levels decreased to nearly those seen in the nonpregnant subjects."	1.27	Circadian rhythm of plasma atrial natriuretic peptide, aldosterone, and blood pressure during the third trimester in normal and preeclamptic pregnancies. ( Miyamoto, S; Nakano, H; Shimokawa, H; Sumioki, H; Touno, A, 1988)
"Aldosterone was present in low concentration in the earliest adrenals examined, and a positive correlation existed between total tissue aldosterone and gestational age (r = 0."	1.27	Concentration and molecular forms of active and inactive renin in human fetal kidney, amniotic fluid and adrenal gland: evidence for renin-angiotensin system hyperactivity in 2nd trimester of pregnancy. ( Peart, WS; Porter, KA; Taylor, GM; Zondek, LH; Zondek, T, 1986)
"Captopril was given to pregnant and nonpregnant animals during the developmental phase of hypertension and to nonpregnant animals with established (4 weeks of treatment) hypertension."	1.26	Aldosterone-induced hypertension: effects of a kininase inhibitor. ( Douglas, BH; Evans, TA; Lundy, JH; Parks, BR, 1980)
"Fetal adrenal glands in prolonged pregnancy synthetized in vitro less amount of radioactive DOC, B and 18-OH-DOC."	1.26	Influence of ACTH secreting tumor (MtTF4) on fetal rat adrenal gland steroidogenesis in vitro in prolonged pregnancy. ( Klepac, R, 1981)
"PGF2 alpha was the same in preeclampsia and normotensive pregnancy but higher than in the non-pregnant group."	1.26	Prostaglandins, catecholamines, renin and aldosterone during hypertensive and normotensive pregnancy. ( Christensen, NJ; Christensen, P; Johannesen, P; Kornerup, HJ; Kristensen, S; Lauritsen, JG; Leyssac, PP; Pedersen, EB; Rasmussen, AB; Wohlert, M, 1982)
"We report a case of primary hyperaldosteronism in a 37-year-old woman presenting early in pregnancy with hypertension and hypokalaemia."	1.26	Primary hyperaldosteronism in pregnancy. ( Buchanan, JD; Hammond, TG; Scoggins, BA; Thatcher, R; Whitworth, JA, 1982)
"2) PRA and PA in toxemia of pregnancy were obviously lower in comparison with normal pregnancy in the corresponding period."	1.26	[Renin and aldosterone during pregnancy (author's transl)]. ( Mochizuki, M; Motoyama, S; Tojo, S, 1980)
"In 6 patients with salt-losing congenital adrenal hyperplasia due to 21-hydroxylase deficiency, the renin activity was also elevated and normalized after corticoid treatment."	1.26	Enzyme immunoassay for plasma renin activity: II. Clinical application. ( Büchner, M; Dörner, G; Garten, CD; Hubl, W; Schmidt, PK, 1981)
"Aldosterone was measured before and after chromatographic purification."	1.26	Compounds in the urinary pH 1 extract reacting with corticosteroid and tetrahydrocorticosteroid antisera. Separation of a nonpolar substance with affinity to a tetrahydroaldosterone antiserum. ( Connolly, TM; Kohl, KH; Lichtwald, K; Vecsei, P, 1978)
"Experimental toxemia of pregnancy was induced in 8 pregnant monkeys (Macacamulatta) by reducing the abdomiinal aorta to one-third of its original diameter during the last month of gestation."	1.26	Experimental toxemia of pregnancy in the monkey, with a preliminary report on renin and aldosterone. ( Abitbol, MM; Driscoll, SG; Gallo, GR; Ober, MB; Pirani, CL, 1977)
"Fetal body weight was also reduced."	1.26	Fetal rat adrenal growth and steroidogenesis in vitro after maternal dexamethasone treatment. ( Klepac, R; Milković, K, 1979)
"Aldosterone levels were low or undetectable in adrenal insufficiency and plasma renin levels were grossly elevated in one patient with adrenal insufficiency but within the normal range in the other."	1.26	Plasma renin and aldosterone in pregnancy complicated by adrenal insufficiency. ( Craven, DJ; Symonds, EM, 1977)
"Secondary hyperaldosteronism was almost exclusively observed in patients who had been taking diuretics during the last few days before the measurements were done."	1.26	[Catamnestic and endocrinological investigations in women with idiopathic edema (author's transl)]. ( Oelkers, W; Palicki, H; Rawer, C; Schöneshöfer, M; Wiederholt, M, 1977)
"Aldosterone metabolism has been shown to be altered in pregnancy."	1.25	The metabolism of orally and intravenously administered labeled aldosterone in pregnant subjects. ( Little, B; Tait, JF, 1969)

Timeframe	Studies, this research(%)	All Research%
pre-1990	509 (62.38)	18.7374
1990's	107 (13.11)	18.2507
2000's	77 (9.44)	29.6817
2010's	91 (11.15)	24.3611
2020's	32 (3.92)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Diagnostic Test Study of Characteristic Sound Waves in Radial Artery of Early Pregnant Women[NCT04717661]		152 participants (Anticipated)	Observational	2021-01-01	Recruiting
A Diagnostic Test Study of Characteristic Sound Waves in the Middle and Third Trimester of Pregnancy Women[NCT04861883]		152 participants (Anticipated)	Observational	2021-04-09	Recruiting
PREMALDO : Aldosterone Resistance in Preterm Infants : Assessment by a Non Invasive Measurement of Urinary Aldosterone[NCT01176162]		170 participants (Actual)	Observational	2010-01-31	Completed
HyperAldosteronism in Pregnancy Predicted Impacts[NCT05636995]		200 participants (Anticipated)	Observational [Patient Registry]	2023-01-10	Recruiting
Increased Activity of the Epithelial Sodium Channel (ENaC) in Diabetic Nephropathy[NCT01918488]		80 participants (Anticipated)	Interventional	2013-10-31	Enrolling by invitation
High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure[NCT02429388]	Phase 4	0 participants (Actual)	Interventional	2014-05-31	Withdrawn (stopped due to Principal Investigator left institution prior to subjects being enrolled)
[NCT00005456]		0 participants	Observational	1990-12-31	Completed
[NCT00005207]		0 participants	Observational	1987-09-30	Completed
Prospective Cohort Evaluation of Cardiac Function With Echocardiography and Serum B-type Natriuretic Peptide (BNP) in Obstetrical Patients With and Without a History of Cardiac Disease[NCT00759733]		0 participants (Actual)	Observational	2008-07-31	Withdrawn (stopped due to No participants enrolled)
Are Renal Artery Doppler Indices Different Between Monochorionic Diamniotic Twins With Twin-twin Transfusion Syndrome and Monochorionic Diamniotic Twins Without Twin-twin Transfusion Syndrome?[NCT03449823]		24 participants (Actual)	Observational	2016-09-09	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Chronic hypertension and superimposed preeclampsia: screening and diagnosis. American journal of obstetrics and gynecology, 2022, Volume: 226, Issue:2S Topics: Aldosterone; Angiogenic Proteins; Biomarkers; Chronic Disease; Cytokines; Female; Humans; Hypertensi	2022
Management and Outcomes of Primary Aldosteronism in Pregnancy: A Systematic Review. Hypertension (Dallas, Tex. : 1979), 2022, Volume: 79, Issue:9 Topics: Adrenalectomy; Aldosterone; Female; Humans; Hyperaldosteronism; Hypertension; Pregnancy; Retrospecti	2022
HCG-responsive aldosteronoma with transient secretion during pregnancy confirmed through HCG-stimulated adrenal venous sampling. Frontiers in endocrinology, 2023, Volume: 14 Topics: Adrenal Glands; Adrenalectomy; Adrenocortical Adenoma; Aldosterone; Female; Humans; Hyperaldosteroni	2023
Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Hypertension (Dallas, Tex. : 1979), 2023, Volume: 80, Issue:5 Topics: Aldosterone; American Heart Association; Cardiovascular Diseases; Female; Humans; Hypertension; Moth	2023
Proceedings. Mathematical, physical, and engineering sciences, 2019, Volume: 475, Issue:2227 Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P	2019
Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2020, Volume: 52, Issue:6 Topics: Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Aldosterone; Angiotensin II Type 1 Receptor Blocke	2020
Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. The New England journal of medicine, 2020, 09-24, Volume: 383, Issue:13 Topics: 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Adrenal Hyperplasia, Congenital; Aldosterone; Androgen	2020
Primary Aldosteronism Presenting with Hypertension Five Days after Delivery: A Case Report and Literature Review. Internal medicine (Tokyo, Japan), 2022, Feb-15, Volume: 61, Issue:4 Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Adult; Aldosterone; Female; Humans;	2022
Roles of the circulating renin-angiotensin-aldosterone system in human pregnancy. American journal of physiology. Regulatory, integrative and comparative physiology, 2014, Jan-15, Volume: 306, Issue:2 Topics: Aldosterone; Angiotensins; Female; Humans; Pregnancy; Renin; Renin-Angiotensin System	2014
Roles of the circulating renin-angiotensin-aldosterone system in human pregnancy. American journal of physiology. Regulatory, integrative and comparative physiology, 2014, Jan-15, Volume: 306, Issue:2 Topics: Aldosterone; Angiotensins; Female; Humans; Pregnancy; Renin; Renin-Angiotensin System	2014
Roles of the circulating renin-angiotensin-aldosterone system in human pregnancy. American journal of physiology. Regulatory, integrative and comparative physiology, 2014, Jan-15, Volume: 306, Issue:2 Topics: Aldosterone; Angiotensins; Female; Humans; Pregnancy; Renin; Renin-Angiotensin System	2014
Roles of the circulating renin-angiotensin-aldosterone system in human pregnancy. American journal of physiology. Regulatory, integrative and comparative physiology, 2014, Jan-15, Volume: 306, Issue:2 Topics: Aldosterone; Angiotensins; Female; Humans; Pregnancy; Renin; Renin-Angiotensin System	2014
The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad. Clinical science (London, England : 1979), 2014, Volume: 126, Issue:8 Topics: Aldosterone; Animals; Female; Humans; Pre-Eclampsia; Pregnancy; Receptor, Angiotensin, Type 1; Renin	2014
[Hypertension in the course of primary aldosteronism during pregnancy]. Postepy higieny i medycyny doswiadczalnej (Online), 2015, Feb-15, Volume: 69 Topics: Acid Sensing Ion Channel Blockers; Aldosterone; Amiloride; Antihypertensive Agents; Eplerenone; Fema	2015
Prenatal phthalate exposure: epigenetic changes leading to lifelong impact on steroid formation. Andrology, 2016, Volume: 4, Issue:4 Topics: Aldosterone; Animals; Diethylhexyl Phthalate; Epigenesis, Genetic; Estradiol; Female; Male; Plastici	2016
Salt, aldosterone and extrarenal Na Placenta, 2017, Volume: 56 Topics: Aldosterone; Animals; Blood Pressure; Female; Humans; Placenta; Pre-Eclampsia; Pregnancy; Sodium	2017
Hyperaldosteronism in pregnancy. Therapeutic advances in cardiovascular disease, 2009, Volume: 3, Issue:2 Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aldosterone; Female; Humans; Hyperaldosteronism; Pregnancy; P	2009
Aldosterone, maternal volume status and healthy pregnancies: a cycle of differing views. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:6 Topics: Aldosterone; Blood Volume; Female; Humans; Models, Biological; Pre-Eclampsia; Pregnancy; Renin-Angio	2009
Factors affecting the aldosterone/renin ratio. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2012, Volume: 44, Issue:3 Topics: Aldosterone; Diagnostic Tests, Routine; Female; Humans; Hyperaldosteronism; Male; Pregnancy; Renin;	2012
The mineralocorticoid signaling pathway throughout development: expression, regulation and pathophysiological implications. Biochimie, 2013, Volume: 95, Issue:2 Topics: Aldosterone; Animals; Brain; Female; Fetus; Gene Expression Regulation, Developmental; Heart; Humans	2013
The role of the renin-angiotensin-aldosterone system in preeclampsia: genetic polymorphisms and microRNA. Journal of molecular endocrinology, 2013, Volume: 50, Issue:2 Topics: Aldosterone; Angiotensinogen; Female; Gene Expression Regulation; Humans; MicroRNAs; Mutation; Pepti	2013
THE ADRENAL CORTEX AND REPRODUCTIVE FUNCTIONS. Modern trends in human reproductive physiology, 1963, Volume: 15 Topics: Addison Disease; Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormon	1963
ALDOSTERONE: ITS BIOCHEMISTRY AND PHYSIOLOGY. Advances in metabolic disorders, 1964, Volume: 15 Topics: Aldosterone; Angiotensins; Biochemical Phenomena; Biochemistry; Blood; Edema; Female; Homeostasis; H	1964
Water and sodium retention in edematous disorders: role of vasopressin and aldosterone. The American journal of medicine, 2006, Volume: 119, Issue:7 Suppl 1 Topics: Aldosterone; Body Water; Edema; Female; Heart Failure; Humans; Hyponatremia; Liver Cirrhosis; Pregna	2006
Human adrenal cortex hyperfunction due to LH/hCG. Molecular and cellular endocrinology, 2007, Apr-15, Volume: 269, Issue:1-2 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfunction; Aldosterone; Androge	2007
The emerging role of ACE2 in physiology and disease. The Journal of pathology, 2007, Volume: 212, Issue:1 Topics: Aldosterone; Angiotensin-Converting Enzyme 2; Animals; Cardiovascular Diseases; Coronavirus; Female;	2007
Role of aldosterone availability in preeclampsia. Molecular aspects of medicine, 2007, Volume: 28, Issue:2 Topics: Aldosterone; Blood Pressure; Cytochrome P-450 CYP11B2; Female; Humans; Models, Biological; Pre-Eclam	2007
The role of adrenal steroidogenesis in arterial hypertension. Endocrine development, 2008, Volume: 13 Topics: Adrenal Glands; Aldosterone; Animals; Blood Pressure; Female; Humans; Hyperaldosteronism; Hypertensi	2008
Mineralocorticoids and the regulation of sodium metabolism in normal and hypertensive pregnancy: a review. Clinical and experimental hypertension, 1980, Volume: 2, Issue:5 Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Angiotensin II; Desoximetasone; Desoxycorticosteron	1980
[Progress and the current status of steroid hormone assay]. Rinsho byori. The Japanese journal of clinical pathology, 1982, Volume: Suppl 52 Topics: Aldosterone; Androgens; Binding, Competitive; Chromatography, Gas; Chromatography, High Pressure Liq	1982
[Renin-angiotensin-aldosterone function tests]. Nihon rinsho. Japanese journal of clinical medicine, 1982, Volume: 40, Issue:9 Topics: Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Desoxycorti	1982
[Biosynthesis and secretion of steroid hormones]. Rinsho byori. The Japanese journal of clinical pathology, 1982, Volume: Suppl 52 Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aldosterone; Androgens; Animal	1982
Renal sodium and water handling in pregnancy. Obstetrics and gynecology annual, 1984, Volume: 13 Topics: Aldosterone; Body Weight; Desoxycorticosterone; Diuretics; Female; Glomerular Filtration Rate; Homeo	1984
[Endocrine dysfunctions in newborn infants during the period of adaptation]. Pediatriia, 1984, Issue:4 Topics: Adrenal Insufficiency; Aldosterone; Androgen-Insensitivity Syndrome; Congenital Hypothyroidism; Dana	1984
[Hypertensinogenic steroids]. Nihon rinsho. Japanese journal of clinical medicine, 1984, Volume: 42, Issue:11 Topics: Aldosterone; Animals; Blood Pressure; Calcium; Catecholamines; Desoxycorticosterone; Female; Glucoco	1984
[New mineralocorticoids and mineralocorticoid-like steroids]. Nihon rinsho. Japanese journal of clinical medicine, 1984, Volume: 42, Issue:11 Topics: Aldosterone; Androstenedione; Animals; Desoxycorticosterone; Female; Humans; Hypertension; Pregnancy	1984
Primary hyperaldosteronism. Pharmacology & therapeutics, 1980, Volume: 9, Issue:3 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Amiloride; Diagnosis, Differential; F	1980
Hypertension in pregnancy. Contributions to nephrology, 1980, Volume: 23 Topics: Aldosterone; Angiotensins; Female; Humans; Hypertension; Kidney; Pre-Eclampsia; Pregnancy; Pregnancy	1980
Sodium and mineralocorticoids in normal pregnancy. Kidney international, 1980, Volume: 18, Issue:2 Topics: Aldosterone; Angiotensinogen; Desoxycorticosterone; Diet, Sodium-Restricted; Diuretics; Female; Huma	1980
Renal hemodynamics and volume homeostasis during pregnancy in the rat. Kidney international, 1980, Volume: 18, Issue:2 Topics: Aldosterone; Animals; Blood Volume; Extracellular Space; Female; Glomerular Filtration Rate; Hemodyn	1980
Transport of protein-bound hormones into tissues in vivo. Endocrine reviews, 1981,Winter, Volume: 2, Issue:1 Topics: Aldosterone; Animals; Biological Transport, Active; Blood-Brain Barrier; Capillary Permeability; Car	1981
Control of vascular reactivity in pregnancy: the basis for therapeutic approaches to prevent pregnancy-induced hypertension. Seminars in perinatology, 1994, Volume: 18, Issue:2 Topics: Aldosterone; Angiotensin II; Female; Humans; Hypertension; Metabolic Clearance Rate; Pregnancy; Preg	1994
[Antenatal form of Bartter's syndrome]. Annales de pediatrie, 1993, Volume: 40, Issue:2 Topics: Aldosterone; Bartter Syndrome; Calcium; Female; Fetal Diseases; Gestational Age; Humans; Indomethaci	1993
Secondary aldosteronism. Endocrinology and metabolism clinics of North America, 1995, Volume: 24, Issue:3 Topics: Aldosterone; Blood Pressure; Edema; Female; Humans; Hyperaldosteronism; Hypertension, Renovascular;	1995
Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure. Steroids, 1996, Volume: 61, Issue:4 Topics: Aldosterone; Androstenes; Angiotensinogen; Animals; Blood Pressure; Contraceptives, Oral; Estrogens;	1996
[11 beta-hydroxysteroid dehydrogenases: key enzymes in the action of mineralocorticoids and glucocorticoids]. Deutsche medizinische Wochenschrift (1946), 1999, Jan-22, Volume: 124, Issue:3 Topics: 11-beta-Hydroxysteroid Dehydrogenases; ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; A	1999
[Sodium restriction during pregnancy: an outdated advice]. Nederlands tijdschrift voor geneeskunde, 1999, Oct-23, Volume: 143, Issue:43 Topics: Adult; Aldosterone; Diet, Sodium-Restricted; Female; Hemodynamics; Humans; Luteal Phase; Pregnancy;	1999
Clinical implications of the ovarian/endometrial renin-angiotensin-aldosterone system. Annals of the New York Academy of Sciences, 2000, Volume: 900 Topics: Aldosterone; Animals; Endometrium; Female; Humans; Hypertension; Male; Menstrual Cycle; Ovary; Pre-E	2000
Molecular mechanisms of human hypertension. Cell, 2001, Feb-23, Volume: 104, Issue:4 Topics: Aldosterone; Animals; Female; Genes, Recessive; Humans; Hypertension; Male; Mineralocorticoids; Mode	2001
The role of prolactin in mammogenesis and lactogenesis. Advances in experimental medicine and biology, 1977, Volume: 80 Topics: Age Factors; Aldosterone; Animals; Breast; Dopamine; Estrogens; Female; Glucocorticoids; Growth Horm	1977
Sodium and mineralocorticoids in normal and abnormal pregnancy. Advances in nephrology from the Necker Hospital, 1977, Volume: 7 Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Animals; Blood Volume; Body Weight; Circadian Rhyth	1977
[Pathogenesis of edema in pregnant women]. Akusherstvo i ginekologiia, 1978, Issue:11 Topics: Adrenocorticotropic Hormone; Aldosterone; Blood Volume; Edema; Extracellular Space; Female; Glomerul	1978
Mineralocorticoids in normal and hypertensive pregnancies. Seminars in perinatology, 1978, Volume: 2, Issue:1 Topics: Adrenocorticotropic Hormone; Aldosterone; Desoxycorticosterone; Female; Humans; Hypertension; Pregna	1978
[Physiology of the renin-angiotensin-aldosterone axis]. Revista clinica espanola, 1977, Jan-15, Volume: 144, Issue:1 Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Blood Pressure; Catecholamines; Female; Humans; Kidney;	1977
[Uronephrologic and endocrine changes during normal pregnancy]. La Revue du praticien, 1977, Feb-11, Volume: 27, Issue:9 Topics: Adrenal Cortex Hormones; Aldosterone; Blood Pressure; Chorionic Gonadotropin; Estrogens; Female; Glo	1977
Experimental toxemia of pregnancy: review and speculation. Pathology annual, 1977, Volume: 12 Pt 2 Topics: Aldosterone; Angiotensin II; Animals; Disease Models, Animal; Dogs; Endocrine Glands; Female; Humans	1977
Significance of renin and angiotensin in hypertension. Cardiovascular clinics, 1978, Volume: 9, Issue:1 Topics: Adenoma; Adrenal Cortex Neoplasms; Aldosterone; Angiotensin I; Angiotensin II; Female; Humans; Hyper	1978
Salt, diuretics and pregnancy. Gynecologic and obstetric investigation, 1979, Volume: 10, Issue:4 Topics: Aldosterone; Angiotensin II; Animals; Benzothiadiazines; Diuretics; Female; Glomerular Filtration Ra	1979
Vasopressor substances in normal and abnormal pregnancy. European journal of obstetrics, gynecology, and reproductive biology, 1975, Volume: 5, Issue:1-2 Topics: Adrenal Cortex Hormones; Aldosterone; Angiotensin II; Arginine Vasopressin; Catecholamines; Female;	1975
Anti-steroid antisera in immunoassays and in biomedical research. Journal of immunological methods, 1976, Volume: 12, Issue:1-2 Topics: Aldosterone; Androgens; Animals; Estrogens; Female; Fluorescent Antibody Technique; Haplorhini; Horm	1976
Complications of systemic contraceptive agents: hypertension. The Western journal of medicine, 1975, Volume: 122, Issue:1 Topics: Aldosterone; Angiotensin II; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Drug Combination	1975
Physiological changes in blood volume. CRC critical reviews in clinical laboratory sciences, 1975, Volume: 6, Issue:1 Topics: Aldosterone; Altitude; Androgens; Blood Volume; Bone Marrow; Bone Marrow Cells; Capillary Permeabili	1975
The renin-angiotensin-aldosterone system in preeclampsia. A review. Clinics in perinatology, 1991, Volume: 18, Issue:4 Topics: Aldosterone; Angiotensin II; Biochemical Phenomena; Biochemistry; Female; Hemodynamics; Humans; Kall	1991
[Plasma concentration of atrial natriuretic peptide, vasopressin and aldosterone in the umbilical cord blood: its relation to perinatal asphyxia]. Anales espanoles de pediatria, 1990, Volume: 32, Issue:1 Topics: Aldosterone; Asphyxia Neonatorum; Atrial Natriuretic Factor; Female; Fetal Blood; Humans; Infant, Ne	1990
Control of aldosterone secretion in domestic mammals during the perinatal period. Reproduction, nutrition, developpement, 1985, Volume: 25, Issue:5 Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Animals, Newborn; Cattle; Female;	1985
Role of exogenous factors in alterations of red cell Na+-Li+ exchange and Na+-K+ cotransport in essential hypertension, primary hyperaldosteronism, and hypokalemia. Scandinavian journal of clinical and laboratory investigation. Supplementum, 1986, Volume: 180 Topics: Adult; Aldosterone; Biological Transport, Active; Body Weight; Erythrocytes; Fatty Acids; Female; Ge	1986
[Vasoactive substances in normal pregnancy and in pregnancy complicated by gestosis]. Minerva ginecologica, 1988, Volume: 40, Issue:8 Topics: Aldosterone; Female; Humans; Hypertension; Kallikreins; Pre-Eclampsia; Pregnancy; Pregnancy Complica	1988
Regulation of aldosterone biosynthesis. Physiological and clinical aspects. Monographs on endocrinology, 1987, Volume: 29 Topics: Adrenal Cortex; Age Factors; Aldosterone; Biogenic Amines; Cations; Enzyme Inhibitors; Feedback; Fem	1987
The renal pressor system in human pregnancy. The Journal of reproductive medicine, 1972, Volume: 8, Issue:3 Topics: Aldosterone; Alpha-Globulins; Angiotensin II; Contraceptives, Oral; Female; Humans; Hypertension; Ju	1972
[Receptors of steroid hormones: Corticoids]. Nihon rinsho. Japanese journal of clinical medicine, 1974, Nov-10, Volume: 32, Issue:11 Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Anura; Binding Sites; Biological Transport; Cell Nucl	1974
Human chorionic somatomammotrophin and its clinical significance. Clinical endocrinology, 1972, Volume: 1, Issue:2 Topics: Abortion, Threatened; Aldosterone; Animals; Carbohydrate Metabolism; Choriocarcinoma; Diabetes Melli	1972
[Metabolism of corticoids]. Nihon rinsho. Japanese journal of clinical medicine, 1974, Nov-10, Volume: 32, Issue:11 Topics: Adipose Tissue; Adrenal Cortex Hormones; Aldosterone; Animals; Arthritis, Rheumatoid; Brain; Chemica	1974
Endocrine relations between mother and fetus. Annual review of medicine, 1968, Volume: 19 Topics: Aldosterone; Angiotensin II; Animals; Biological Transport, Active; Breast; Dehydroepiandrosterone;	1968
[The renin-angiotensin-aldosterone system in late gestosis]. Ceskoslovenska fysiologie, 1968, Volume: 17, Issue:2 Topics: Aldosterone; Angiotensin II; Female; Humans; Hypertension; Juxtaglomerular Apparatus; Pre-Eclampsia;	1968
[Recent data on the physiopathologic metabolism of aldosterone]. Exposes annuels de biochimie medicale, 1967, Volume: 28 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Animals; Aorta; Edema; Female; Heart Disea	1967
Control of aldosterone secretion by the renin-angiotensin system and by corticotropin. Advances in internal medicine, 1968, Volume: 14 Topics: Addison Disease; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Female; Humans;	1968
[Experimental bases of the pathophysiology of the renin-angiotensin system]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1968, Volume: 74 Topics: Adrenal Glands; Aldosterone; Angiotensin II; Animals; Female; Humans; Hyperaldosteronism; Hypertensi	1968
Practically applicable results of twenty years of research in endocrinology. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 1968, Volume: 12 Topics: Adrenocorticotropic Hormone; Aldosterone; Anabolic Agents; Androgens; Animals; Calcitonin; Chemical	1968
[Studies on renin in normal pregnancy]. Ginekologia polska, 1969, Volume: 40, Issue:6 Topics: Aldosterone; Angiotensin II; Female; Glomerular Filtration Rate; Humans; Placenta; Posture; Pregnanc	1969
[Renovascular hypertension in pregnancy]. Naika. Internal medicine, 1969, Volume: 24, Issue:4 Topics: Aldosterone; Angiotensin II; Blood Pressure; Chronic Disease; Female; Humans; Hypertension, Renal; K	1969
[Renin-angiotensin-aldosterone system from the clinical viewpoint]. Deutsche medizinische Wochenschrift (1946), 1970, Feb-20, Volume: 95, Issue:8 Topics: Addison Disease; Aldosterone; Angiotensin II; Cushing Syndrome; Female; Humans; Hyperaldosteronism;	1970
Pre-eclampsia and related complications of pregnancy. American journal of obstetrics and gynecology, 1970, May-01, Volume: 107, Issue:1 Topics: Adult; Aldosterone; Angiotensin II; Blood Coagulation Disorders; Catecholamines; Diagnosis, Differen	1970
Recent advances in human steroid metabolism. Advances in clinical chemistry, 1970, Volume: 13 Topics: Adrenocorticotropic Hormone; Aldosterone; Carbon Isotopes; Dexamethasone; Estriol; Etiocholanolone;	1970
[Menstrual cycle, pregnancy, and aldosterone]. Nihon rinsho. Japanese journal of clinical medicine, 1971, Volume: 29, Issue:3 Topics: Aldosterone; Angiotensin II; Female; Fetus; Humans; Hyperaldosteronism; Menstruation; Placenta; Preg	1971
Renin, angiotensin and aldosterone in human pregnancy and the menstrual cycle. Scottish medical journal, 1971, Volume: 16, Issue:3 Topics: Adult; Aldosterone; Amniotic Fluid; Angiotensin II; Endopeptidases; Estrogens; Extraembryonic Membra	1971
[On mechanisms acting upon arterial blood pressure and sodium metabolism, particularly during pregnancy]. Ginekologia polska, 1971, Volume: 42, Issue:6 Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Feedback; Female; Humans; Hypertension; Kidney	1971
The role of the developing kidney in the maintenance of internal stability. Journal of the Royal College of Physicians of London, 1972, Volume: 6, Issue:3 Topics: Aldosterone; Angiotensin II; Erythropoietin; Female; Fetus; Glomerular Filtration Rate; Homeostasis;	1972
The cardiovascular effects of oral contraceptives. Modern concepts of cardiovascular disease, 1972, Volume: 41, Issue:8 Topics: Aldosterone; Angiotensin II; Blood Coagulation; Blood Flow Velocity; Blood Vessels; Cardiovascular S	1972
Salt, water, and rest as a preventative for toxemia of pregnancy. A commentary and review. The Journal of reproductive medicine, 1972, Volume: 9, Issue:5 Topics: Aldosterone; Angiotensin II; Blood Volume; Body Weight; Diabetes Insipidus; Diuresis; Diuretics; Ede	1972
[Water-electrolyte changes during normal and pathological pregnancy]. Journal de medecine de Lyon, 1972, Nov-05, Volume: 53, Issue:236 Topics: Aldosterone; Angiotensin II; Blood Volume; Capillary Permeability; Chlorides; Female; Humans; Kidney	1972
The physiology of renin. Archives of internal medicine, 1973, Volume: 131, Issue:6 Topics: Aldosterone; Angiotensin II; Edema; Extracellular Space; Female; Glomerular Filtration Rate; Humans;	1973
Renin, angiotensin, and aldosterone. Obstetrics and gynecology annual, 1974, Volume: 3, Issue:0 Topics: Adrenal Glands; Aldosterone; Angiotensin II; Animals; Blood Pressure; Endopeptidases; Female; Glomer	1974
Estrogens and the kidney. Kidney international, 1974, Volume: 6, Issue:5 Topics: Aldosterone; Alkaline Phosphatase; Angiotensin II; Animals; Corticosterone; Diethylstilbestrol; Dogs	1974
[Oral contraceptives and arterial hypertension]. Medizinische Klinik, 1974, Dec-13, Volume: 69, Issue:50 Topics: Aldosterone; Angiotensin II; Animals; Blood Circulation; Blood Pressure; Body Weight; Contraceptives	1974
Pregnancy and appetite for sodium chloride in the rat. Nutrition reviews, 1972, Volume: 30, Issue:4 Topics: Adrenal Glands; Aldosterone; Animals; Appetite; Deficiency Diseases; Diet, Sodium-Restricted; Female	1972
Sodium metabolism, aldosterone and the hypertensive disorders of pregnancy. The Journal of reproductive medicine, 1972, Volume: 8, Issue:3 Topics: Aldosterone; Diuretics; Estrogens; Female; Humans; Hypertension; Posture; Pre-Eclampsia; Pregnancy;	1972
[Endocrine correlations during pregnancy (review of the literature)]. Akusherstvo i ginekologiia, 1972, Volume: 48, Issue:11 Topics: Adrenal Cortex Hormones; Adrenal Glands; Adult; Aldosterone; Androgens; Chorionic Gonadotropin; Estr	1972
Sodium and diuretics in pregnancy. The New England journal of medicine, 1973, Apr-26, Volume: 288, Issue:17 Topics: Aldosterone; Animals; Body Water; Body Weight; Diuretics; Edema; Female; Homeostasis; Humans; Kidney	1973
The use of spironolactone in the diagnosis and the treatment of hypertension associated with mineralocorticoid excess. American heart journal, 1973, Volume: 86, Issue:3 Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Aldosterone; Antihypertensive Agents; Carc	1973
Proceedings: Hormonal regulation of breast development and activity. The Journal of investigative dermatology, 1974, Volume: 63, Issue:1 Topics: Aldosterone; Animals; Breast; Cell Differentiation; DNA Replication; Estrogens; Female; Hormones; Hu	1974
Immunology of gonadal steroids. Vitamins and hormones, 1973, Volume: 31 Topics: Aldosterone; Animals; Antibodies; Embryo Implantation; Estrogens; Estrus; Female; Gonadal Steroid Ho	1973
[Side-effects of cortisone derivatives]. Der Internist, 1967, Volume: 8, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Aldosterone; Betamethasone; Cortisone; Dexamethasone; Female; Humans	1967
Use and abuse of thiazides in pregnancy. Clinical obstetrics and gynecology, 1968, Volume: 11, Issue:2 Topics: Aldosterone; Diabetes Mellitus; Diuretics; Edema; Female; Hematologic Diseases; Humans; Hypokalemia;	1968
Renal function in normal pregnancy. Clinical obstetrics and gynecology, 1968, Volume: 11, Issue:2 Topics: Aldosterone; Blood Urea Nitrogen; Circadian Rhythm; Estradiol; Female; Glomerular Filtration Rate; G	1968
[Physiopathology of water-sodium metabolism during pregnancy. I. Glomerulo-tubular function and its mechanism of regulation]. Rivista di ostetricia e ginecologia, 1967, Volume: 22, Issue:1 Topics: Aldosterone; Female; Glomerular Filtration Rate; Humans; Juxtaglomerular Apparatus; Kidney Tubules;	1967
[Corticosteroids during pregnancy; metabolic aspects]. Rivista di ostetricia e ginecologia, 1967, Volume: 22, Issue:5 Topics: Adrenal Glands; Aldosterone; Female; Fetus; Glucocorticoids; Humans; Placenta; Pregnancy	1967
[Estriol]. Medizinische Klinik, 1968, Nov-22, Volume: 63, Issue:47 Topics: Aldosterone; Estriol; Female; Gestational Age; Humans; Hydroxyproline; Pregnancy; Serum Globulins	1968
Endocrine control of calcium and magnesium metabolism in ruminants. The Proceedings of the Nutrition Society, 1969, Volume: 28, Issue:2 Topics: Adrenalectomy; Aldosterone; Animals; Calcitonin; Calcium; Cattle; Cattle Diseases; Cortisone; Dogs;	1969
Edema and pulmonary edema: pathologic physiology and differential diagnosis. Progress in cardiovascular diseases, 1971, Volume: 13, Issue:6 Topics: Adrenal Glands; Aldosterone; Diagnosis, Differential; Edema; Extracellular Space; Female; Heart Dise	1971
[Mineralocorticoid function of the adrenal cortex under normal conditions and in pathology (review of the literature)]. Voprosy okhrany materinstva i detstva, 1971, Volume: 16, Issue:2 Topics: Adrenal Gland Diseases; Adrenal Glands; Adrenal Insufficiency; Adrenalectomy; Adult; Aging; Aldoster	1971
The metabolic influence of progestins. Advances in metabolic disorders, 1971, Volume: 5 Topics: Aldosterone; Amino Acids; Anabolic Agents; Carbon Dioxide; Clinical Trials as Topic; Contraceptives,	1971
[The third factor]. Naika. Internal medicine, 1971, Volume: 28, Issue:1 Topics: Aldosterone; Animals; Biological Assay; Dogs; Extracorporeal Circulation; Female; Glomerular Filtrat	1971
Reviews of the progress of dairy science. Section A. Physiology. Hormonal control of lactogenesis. The Journal of dairy research, 1971, Volume: 38, Issue:2 Topics: Aldosterone; Animals; Cattle; Chorionic Gonadotropin; Corticosterone; Cricetinae; Dogs; Female; Goat	1971
Plasma renin concentration in human hypertension. American heart journal, 1967, Volume: 74, Issue:3 Topics: Aldosterone; Female; Heart Failure; Humans; Hypertension; Hypertension, Malignant; Kidney Failure, C	1967

Article	Year
Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort. Reproductive biology and endocrinology : RB&E, 2021, Nov-04, Volume: 19, Issue:1 Topics: Adult; Aldosterone; Cohort Studies; Corpus Luteum; Female; Humans; Imaging, Three-Dimensional; Longi	2021
Aldosterone-Signaling Defect Exacerbates Sodium Wasting in Very Preterm Neonates: The Premaldo Study. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:11 Topics: Adolescent; Adult; Aging; Aldosterone; Birth Weight; Electrolytes; Female; Fetal Blood; Gestational	2015
Changes in the renin-angiotensin-aldosterone system in response to dietary salt intake in normal and hypertensive pregnancy. A randomized trial. Journal of the American Society of Hypertension : JASH, 2016, Volume: 10, Issue:11 Topics: Adult; Aldosterone; Angiotensin II; Blood Pressure Determination; Creatinine; Diet, Sodium-Restricte	2016
Novel inflammatory markers in overweight women with and without polycystic ovary syndrome and following pharmacological intervention. Journal of endocrinological investigation, 2010, Volume: 33, Issue:4 Topics: Adiponectin; Adiposity; Aldosterone; Biomarkers; Body Mass Index; Cross-Sectional Studies; Female; H	2010
The effect of prostaglandin E2 upon the biochemical response to infused angiotensin II in human pregnancy. Clinical science (London, England : 1979), 1984, Volume: 66, Issue:4 Topics: Adolescent; Adult; Aldosterone; Angiotensin II; Blood Pressure; Dinoprostone; Female; Humans; Pregna	1984
Prostaglandins, renin, aldosterone, and catecholamines in preeclampsia. Acta medica Scandinavica. Supplementum, 1983, Volume: 677 Topics: Aldosterone; Blood Pressure; Dinoprost; Dinoprostone; Epinephrine; Female; Humans; Norepinephrine; P	1983
Pulmonary edema following ritodrine-saline infusion in premature labor. Obstetrics and gynecology, 1981, Volume: 58, Issue:3 Topics: Aldosterone; Angiotensin I; Female; Glucose; Humans; Infusions, Parenteral; Obstetric Labor, Prematu	1981
Stimulation of aldosterone by ACTH in normal and hypertensive pregnancy. American journal of hypertension, 1995, Volume: 8, Issue:3 Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Female; Humans; Hydrocortisone; Hypertension; Pre-E	1995
Fetotoxicity of angiotensin-converting enzyme inhibition in primate pregnancy: a prospective, placebo-controlled study in baboons (Papio hamadryas). American journal of obstetrics and gynecology, 1994, Volume: 171, Issue:3 Topics: Aldosterone; Analysis of Variance; Angiotensin I; Angiotensin II; Animals; Blood Pressure; Enalapril	1994
Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences. Kidney international, 1997, Volume: 51, Issue:6 Topics: Adolescent; Adult; Aldosterone; Blood Glucose; Female; Heart Rate; Humans; Hypokalemia; Injections,	1997
Plasma human atrial natriuretic peptide, endothelin-1, aldosterone and plasma-renin activity in pregnancy-induced hypertension. Journal of hypertension, 1999, Volume: 17, Issue:9 Topics: Adolescent; Adult; Aldosterone; Atrial Natriuretic Factor; Endothelin-1; Female; Humans; Hypertensio	1999
The renin-aldosterone system in dihydralazine therapy during hypertensive pregnancy. International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:12 Topics: Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Dihydralazine; Electrolytes; Female; H	1978
The placental transfer of mifepristone (RU 486) during the second trimester and its influence upon maternal and fetal steroid concentrations. British journal of obstetrics and gynaecology, 1990, Volume: 97, Issue:5 Topics: Aldosterone; Cortisone; Double-Blind Method; Estradiol; Female; Fetal Blood; Humans; Maternal-Fetal	1990
The effect of epostane, a 3-beta hydroxy steroid dehydrogenase inhibitor, on maternal and fetal steroid levels during mid-gestation. British journal of obstetrics and gynaecology, 1988, Volume: 95, Issue:6 Topics: 3-Hydroxysteroid Dehydrogenases; Adult; Aldosterone; Androstenols; Clinical Trials as Topic; Double-	1988
[Hypotension in pregnancy, a sequela of adrenal cortex insufficiency?]. Geburtshilfe und Frauenheilkunde, 1987, Volume: 47, Issue:12 Topics: Adrenal Insufficiency; Aldosterone; Angiotensin II; Birth Weight; Clinical Trials as Topic; Dihydroe	1987
The effect of prostaglandin E1 upon the pressor and hormonal response to exogenous angiotensin II in human pregnancy. Clinical science (London, England : 1979), 1987, Volume: 72, Issue:3 Topics: Adolescent; Adult; Aldosterone; Alprostadil; Angiotensin II; Blood Pressure; Dose-Response Relations	1987
High blood pressure and oral contraceptives. Changes in plasma renin and renin substrate and in aldosterone excretion. American journal of obstetrics and gynecology, 1968, Aug-15, Volume: 101, Issue:8 Topics: Aldosterone; Angiotensin II; Clinical Trials as Topic; Contraceptives, Oral; Ethinyl Estradiol; Fema	1968
Effect of administered mineralocorticoids or ACTH in pregnant women. Attenuation of kaliuretic influence of mineralocorticoids during pregnancy. The Journal of clinical investigation, 1972, Volume: 51, Issue:6 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aldosterone; Clinical Trials as Topic; Creatinine; D	1972
The metabolic influence of progestins. Advances in metabolic disorders, 1971, Volume: 5 Topics: Aldosterone; Amino Acids; Anabolic Agents; Carbon Dioxide; Clinical Trials as Topic; Contraceptives,	1971

aldosterone and Pregnancy

Research Excerpts

Research

Studies (816)

Authors

Clinical Trials (10)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Perrin, EC	1
South, AM	2
Wiegel, RE	3
Karsten, MJH	1
Reijnders, IF	1
van Rossem, L	1
Willemsen, SP	3
Mulders, AGMGJ	1
Koning, AHJ	1
Steegers, EAP	2
Danser, AHJ	2
Steegers-Theunissen, RPM	3
Pastén, V	1
Tapia-Castillo, A	1
Fardella, CE	2
Leiva, A	1
Carvajal, CA	2
Lewandowski, KC	2
Tadros-Zins, M	2
Horzelski, W	2
Grzesiak, M	1
Lewinski, A	2
Kametas, NA	1
Nzelu, D	1
Nicolaides, KH	2
Delić, R	1
Pavalec, M	1
Koren, J	1
Sanga, V	1
Rossitto, G	2
Seccia, TM	2
Rossi, GP	2
Dwivedi, D	1
Chander, B	1
Menkhorst, E	1
Zhou, W	1
Santos, L	1
Zhang, JG	1
St-Pierre, Y	1
Young, MJ	1