aldosterone has been researched along with Muscular Diseases in 14 studies
Muscular Diseases: Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among 10 patients with primary aldosteronism and 3 patients with pseudoaldosteronism, 5 patients were admitted to our hospital because of muscular weakness." | 1.27 | Hypokalemic myopathy associated with primary aldosteronism and glycyrrhizine-induced pseudoaldosteronism. ( Atsumi, T; Ishikawa, S; Kuzuya, T; Okada, K; Saito, T, 1985) |
| " The syndrome was iatrogenic in two cases depending on the licorice eating and the combined use of diuretics and a 9-alpha-fluoroprednisolone-containing nasal spray in one patient, and on a long-term use of the same nasal decongestant in the other." | 1.26 | [Hypokalemic myopathy in arterial hypertension]. ( Angeletti, G; Filipponi, P; Natali, P; Nicoletti, I; Nunzi, E; Rambotti, P; Santeusanio, F, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Howard, ZM | 1 |
| Rastogi, N | 1 |
| Lowe, J | 2 |
| Hauck, JS | 2 |
| Ingale, P | 1 |
| Gomatam, C | 1 |
| Gomez-Sanchez, CE | 2 |
| Gomez-Sanchez, EP | 2 |
| Bansal, SS | 1 |
| Rafael-Fortney, JA | 2 |
| Chadwick, JA | 1 |
| Shaw, JJ | 1 |
| Guttridge, DC | 1 |
| MCARDLE, B | 1 |
| HANAK, J | 1 |
| ORT, M | 1 |
| OKINAKA, S | 1 |
| Santeusanio, F | 1 |
| Nunzi, E | 1 |
| Natali, P | 1 |
| Nicoletti, I | 1 |
| Angeletti, G | 1 |
| Filipponi, P | 1 |
| Rambotti, P | 1 |
| Arnold, G | 1 |
| Schüle, B | 1 |
| Mörl, H | 1 |
| Dickson, BA | 1 |
| Franks, RC | 1 |
| Ishikawa, S | 1 |
| Saito, T | 1 |
| Okada, K | 1 |
| Atsumi, T | 1 |
| Kuzuya, T | 1 |
| France, R | 1 |
| Stone, WJ | 1 |
| Michelakis, AM | 1 |
| Island, DP | 1 |
| Merrill, JM | 1 |
| Tolleson, WJ | 1 |
| Popovtzer, MM | 1 |
| Katz, FH | 1 |
| Pinggera, WF | 1 |
| Robinette, J | 1 |
| Halgrimson, CG | 1 |
| Butkus, DE | 1 |
| Miyazaki, G | 1 |
| Sasano, N | 1 |
| Torikai, T | 1 |
| Fukuchi, S | 1 |
| Kuzin, MI | 1 |
| Kuz'min, NV | 1 |
| Voĭnova, MKh | 1 |
| Kolomenskaia, EA | 1 |
| Van Rooyen, RJ | 1 |
| Ziady, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Open Label Trial of Spironolactone Versus Prednisolone in Corticosteroid-naïve Boys With DMD[NCT03777319] | Phase 1 | 2 participants (Actual) | Interventional | 2018-12-05 | Terminated (stopped due to Inability to recruit participants.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The determination of whether spironolactone has similar efficacy to glucocorticoids in improving muscle strength in steroid naïve DMD patients. This will be determined by measuring the time to complete a 100 meter timed test (100M). (NCT03777319)
Timeframe: 6 months
| Intervention | sec (Number) |
|---|---|
| Spironolactone | -0.6 |
| Prednisolone | -5.3 |
Secondary outcome measures will be Dynamometry score, which is a summation of maximum voluntary isometric contraction test values for knee flexion, knee extension, elbow flexion, and elbow extension (NCT03777319)
Timeframe: 6 months
| Intervention | kg (Number) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Elbow Flexion (Right)-Baseline | Elbow Flexion (Left)-Baseline | Elbow Extension (Right)-Baseline | Elbow Extension (Left)-Baseline | Knee Flexion (Right)-Baseline | Knee Flexion (Left)-Baseline | Knee Extension (Right)-Baseline | Knee Extension (Left)-Baseline | Elbow Flexion (Right)-Month 6 | Elbow Flexion (Left)-Month 6 | Elbow Extension (Right)-Month 6 | Elbow Extension (Left)-Month 6 | Knee Flexion (Right)-Month 6 | Knee Flexion (Left)-Month 6 | Knee Extension (Right)-Month 6 | Knee Extension (Left)-Month 6 | |
| Prednisolone | 3.6 | 4.1 | 5.3 | 4.1 | 3.3 | 3.4 | 4.8 | 5.2 | 2.9 | 3.4 | 4.3 | 3.8 | 4.1 | 3.9 | 6 | 5.1 |
| Spironolactone | 0 | 0 | 0 | 0 | 4.1 | 2.8 | 3.8 | 5.9 | 3.1 | 3.5 | 2.4 | 2.5 | 4.3 | 4.1 | 7.2 | 8.3 |
Electrolytes (Sodium, Potassium, Cloride and Carbon dioxide, mmol/L) will be measured on a monthly basis following initiation of either spironolactone or prednisolone. (NCT03777319)
Timeframe: 6 months
| Intervention | mmol/L (Number) | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sodium-Baseline | Sodium-Month 1 | Sodium-Month 2 | Sodium-Month 3 | Sodium-Month 4 | Sodium-Month 5 | Sodium-Month 6 | Potassium-Baseline | Potassium-Month 1 | Potassium-Month 2 | Potassium-Month 3 | Potassium-Month 4 | Potassium-Month 5 | Potassium-Month 6 | Chloride-Baseline | Chloride-Month 1 | Chloride-Month 2 | Chloride-Month 3 | Chloride-Month 4 | Chloride-Month 5 | Chloride-Month 6 | CO2-Baseline | CO2-Month 1 | CO2-Month 2 | CO2-Month 3 | CO2-Month 4 | CO2-Month 5 | CO2-Month 6 | |
| Prednisolone | 140 | 140 | 139 | 141 | 139 | 139 | 143 | 3.8 | 4 | 4.5 | 3.9 | 4.6 | 4.2 | 3.9 | 105 | 105 | 104 | 105 | 105 | 106 | 105 | 22 | 24 | 24 | 24 | 25 | 26 | 26 |
| Spironolactone | 142 | 142 | 141 | 142 | 139 | 139 | 140 | 4.5 | 4.7 | 4.2 | 4.1 | 4.5 | 4.5 | 4.3 | 103 | 109 | 107 | 103 | 103 | 103 | 101 | 29 | 22 | 25 | 27 | 28 | 28 | 26 |
1 review available for aldosterone and Muscular Diseases
| Article | Year |
|---|---|
METABOLIC MYOPATHIES. THE GLYCOGENOSES AFFECTING MUSCLE, AND HYPO- AND HYPERKALEMIC PERIODIC PARALYSIS.
Topics: Aldosterone; Carbohydrate Metabolism; Glucose-6-Phosphatase; Glucosidases; Glycogen Storage Disease; | 1963 |
13 other studies available for aldosterone and Muscular Diseases
| Article | Year |
|---|---|
Myeloid mineralocorticoid receptors contribute to skeletal muscle repair in muscular dystrophy and acute muscle injury.
Topics: Aldosterone; Animals; Barium Compounds; Chlorides; Cytokines; Diaphragm; Disease Models, Animal; Fem | 2022 |
Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target.
Topics: Aldosterone; Animals; Cell Line; Humans; Lisinopril; Mice; Muscle Fibers, Skeletal; Muscle Proteins; | 2015 |
[TRIAMCINOLONE IN THE TREATMENT OF PAROXYSMAL MYOPLEGIA].
Topics: Adolescent; Aldosterone; Body Fluids; Humans; Hypokalemia; Muscle Spasticity; Muscular Diseases; Par | 1963 |
[Effect of anti-aldosterone drugs on periodic paralysis of the extremities and amyotonia].
Topics: Aldosterone; Disease; Extremities; Familial Mediterranean Fever; Humans; Mineralocorticoid Receptor | 1962 |
[Hypokalemic myopathy in arterial hypertension].
Topics: Adult; Aged; Aldosterone; Diuretics; Fluprednisolone; Glycyrrhiza; Humans; Hypertension; Hypokalemia | 1982 |
[A 54-year-old patient with muscle weakness, hypokalemia and arterial hypertension].
Topics: Adenoma; Adrenal Cortex Neoplasms; Aldosterone; Female; Humans; Hypertension; Hypokalemia; Middle Ag | 1988 |
Aldosterone-producing adenoma presenting with hypokalemic myopathy. Case report and review.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aldosterone; Child; Creatine Kinase; Humans; Hypera | 1988 |
Hypokalemic myopathy associated with primary aldosteronism and glycyrrhizine-induced pseudoaldosteronism.
Topics: Adult; Aged; Aldosterone; Aspartate Aminotransferases; Blood Gas Analysis; Creatine Kinase; Female; | 1985 |
Renal potassium-wasting of unknown cause in a clinical setting of chronic potassium depletion: report of a case.
Topics: Aldosterone; Biopsy; Humans; Kidney; Kidney Tubules, Proximal; Magnesium; Male; Middle Aged; Muscula | 1973 |
Hyperkalemia in salt-wasting nephropathy. Study of the mechanism.
Topics: Aldosterone; Bicarbonates; Desoxycorticosterone; Furosemide; Glomerular Filtration Rate; Glucose; Hu | 1973 |
Adrenocortical carcinoma with an isolated mineralocorticoid excess and recurrency fourteen years after removal of the tumor.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aldosterone; Humans; Hydrocortisone; Hypertension; M | 1973 |
[Potassium and sodium content of the blood and muscle tissue and aldosterone excretion in myasthenia].
Topics: Adolescent; Adult; Aldosterone; Child; Humans; Middle Aged; Muscles; Muscular Diseases; Potassium; S | 1972 |
Hypokalaemic alkalosis following the abuse of purgatives. Case report.
Topics: Adult; Aldosterone; Alkalosis; Amenorrhea; Ammonia; Ammonium Chloride; Cathartics; Edema; Female; Gl | 1972 |