Page last updated: 2024-11-07

aldosterone and Heart Diseases

aldosterone has been researched along with Heart Diseases in 84 studies

Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.

Research Excerpts

ExcerptRelevanceReference
" Angiotensin II and aldosterone often collaborate in pathological situations to induce hypertrophy of cardiomyocytes, vascular inflammation, perivascular and interstitial fibrosis, and microvascular rarefaction."8.89Aldosterone mediates cardiac fibrosis in the setting of hypertension. ( Azibani, F; Chatziantoniou, C; Delcayre, C; Fazal, L; Samuel, JL, 2013)
"Leptin is a newly described regulator of aldosterone synthesis that acts directly on adrenal glomerulosa cells to increase CYP11B2 expression and enhance aldosterone production via calcium-dependent mechanisms."5.42Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis. ( Antonova, G; Belin de Chantemèle, EJ; Bollag, WB; Filosa, JA; Gomez-Sanchez, CE; Groenendyk, J; Huby, AC, 2015)
"Telmisartan was administered to renovascular hypertensive rats at either a high dose (5 mg per kg per day; high-T group) or a low dose (0."5.35Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats. ( Hongo, K; Kawai, M; Komukai, K; Mochizuki, S; Morimoto, S; Nagai, M; Seki, S; Taniguchi, I; Yoshimura, M, 2009)
"Primary aldosteronism (PA) is characterized by the onset of both cardiac and gluco-metabolic alterations."5.34Aldosterone as a key mediator of the cardiometabolic syndrome in primary aldosteronism: an observational study. ( Agostinelli, L; Boscaro, M; Giacchetti, G; Mantero, F; Rilli, S; Ronconi, V; Turchi, F, 2007)
" Angiotensin II and aldosterone often collaborate in pathological situations to induce hypertrophy of cardiomyocytes, vascular inflammation, perivascular and interstitial fibrosis, and microvascular rarefaction."4.89Aldosterone mediates cardiac fibrosis in the setting of hypertension. ( Azibani, F; Chatziantoniou, C; Delcayre, C; Fazal, L; Samuel, JL, 2013)
"Hypertension was induced by continuous angiotensin II (Ang II) infusion via osmotic mini-pumps over 4 weeks."3.77Effect of the plasminogen-plasmin system on hypertensive renal and cardiac damage. ( Cordasic, N; Daniel, C; Hartner, A; Heusinger-Ribeiro, J; Hilgers, KF; Klanke, B; Knier, B; Veelken, R, 2011)
"Primary aldosteronism is common and contributes to adverse cardiovascular, kidney, and metabolic outcomes."2.66MANAGEMENT OF ENDOCRINE DISEASE: The role of surgical adrenalectomy in primary aldosteronism. ( Hundemer, GL; Vaidya, A, 2020)
"Aldosterone is a mineralocorticoid hormone with various direct harmful effects on the myocardium, including increased reactive oxygen species (ROS) generation, which contributes significantly to cardiac mitochondrial dysfunction and cardiac aging."2.61Adrenal βarrestin1 targeting for tobacco-associated cardiac dysfunction treatment: Aldosterone production as the mechanistic link. ( Lymperopoulos, A; Mitaishvili, E; Solesio, ME, 2019)
"Stroke is a severe and frequent complication of Fabry disease (FD), affecting both males and females."1.56Fabry disease patients have an increased risk of stroke in the COVID-19 ERA. A hypothesis. ( Bonardo, P; Reisin, RC; Rozenfeld, P, 2020)
"Primary aldosteronism is characterized by excess aldosterone (ALDO) secretion independent of the renin-angiotensin system and accounts for approximately 10% of hypertension cases."1.46Role and Regulation of MicroRNAs in Aldosterone-Mediated Cardiac Injury and Dysfunction in Male Rats. ( Ball, JP; Hall, ME; Kc, R; Marañon, RO; Reckelhoff, JF; Romero, DG; Syed, M; Yanes Cardozo, LL, 2017)
"Leptin is a newly described regulator of aldosterone synthesis that acts directly on adrenal glomerulosa cells to increase CYP11B2 expression and enhance aldosterone production via calcium-dependent mechanisms."1.42Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis. ( Antonova, G; Belin de Chantemèle, EJ; Bollag, WB; Filosa, JA; Gomez-Sanchez, CE; Groenendyk, J; Huby, AC, 2015)
"Primary hyperaldosteronism is the most common cause of secondary hypertension."1.39Hypertension caused by primary hyperaldosteronism: increased heart damage and cardiovascular risk. ( Abad-Cardiel, M; Alvarez-Álvarez, B; Fernández, C; Fernández-Cruz, A; Luque-Fernandez, L; Martell-Claros, N, 2013)
"Primary aldosteronism (PA) is sometimes associated with the autonomous secretion of cortisol."1.37Cardiovascular complications of patients with aldosteronism associated with autonomous cortisol secretion. ( Hashimoto, K; Monden, T; Mori, M; Nakajima, Y; Okada, S; Ozawa, A; Satoh, T; Shibusawa, N; Taguchi, R; Yamada, M, 2011)
"Both fibrinogen and PAI-1 were independent predictors of the presence of organ damage and their inclusion in a multivariate model eliminated PRA and aldosterone as independent predictors."1.35Relationship of plasma renin with a prothrombotic state in hypertension: relevance for organ damage. ( Casanova-Borca, A; Catena, C; Chiuch, A; Colussi, G; Di Fabio, A; Nadalini, E; Novello, M; Sechi, LA; Uzzau, A, 2008)
"Telmisartan was administered to renovascular hypertensive rats at either a high dose (5 mg per kg per day; high-T group) or a low dose (0."1.35Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats. ( Hongo, K; Kawai, M; Komukai, K; Mochizuki, S; Morimoto, S; Nagai, M; Seki, S; Taniguchi, I; Yoshimura, M, 2009)
"Primary aldosteronism (PA) is characterized by the onset of both cardiac and gluco-metabolic alterations."1.34Aldosterone as a key mediator of the cardiometabolic syndrome in primary aldosteronism: an observational study. ( Agostinelli, L; Boscaro, M; Giacchetti, G; Mantero, F; Rilli, S; Ronconi, V; Turchi, F, 2007)
"Aldosterone plays a key role in the pathogenesis of Ang II-induced organ damage."1.33Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. ( Al-Saadi, N; Dechend, R; Fiebeler, A; Hilfenhaus, G; Jeng, AY; Luft, FC; Maser-Gluth, C; Meiners, S; Muller, DN; Nussberger, J; Rong, S; Shagdarsuren, E; Webb, RL; Wellner, M, 2005)

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-199033 (39.29)18.7374
1990's3 (3.57)18.2507
2000's18 (21.43)29.6817
2010's25 (29.76)24.3611
2020's5 (5.95)2.80

Authors

AuthorsStudies
Han, Y3
Xian, Y3
Gao, X3
Qiang, P3
Hao, J3
Yang, F3
Shimosawa, T3
Chang, Y3
Xu, Q3
Williams, GH2
Chapman, K1
Hundemer, GL1
Vaidya, A1
Hill, MA1
Jaisser, F2
Sowers, JR1
Reisin, RC1
Rozenfeld, P1
Bonardo, P1
Ball, JP1
Syed, M1
Marañon, RO1
Hall, ME1
Kc, R1
Reckelhoff, JF1
Yanes Cardozo, LL1
Romero, DG1
Zhang, YD1
Ding, XJ1
Dai, HY1
Peng, WS1
Guo, NF1
Zhang, Y2
Zhou, QL1
Chen, XL1
Kesireddy, V1
Tan, Y1
Kline, D1
Brock, G1
Odei, JB1
Kluwe, B1
Effoe, VS1
Echouffo Tcheugui, JB1
Kalyani, RR1
Sims, M1
Taylor, HA1
Mongraw-Chaffin, M1
Akhabue, E1
Joseph, JJ1
Solesio, ME1
Mitaishvili, E1
Lymperopoulos, A1
Ocello, A1
La Rosa, S1
Fiorini, F1
Randone, S1
Maccarrone, R1
Battaglia, G1
Granata, A1
Azibani, F1
Fazal, L1
Chatziantoniou, C1
Samuel, JL1
Delcayre, C1
Hattori, T1
Murase, T1
Sugiura, Y1
Nagasawa, K1
Takahashi, K1
Ohtake, M2
Miyachi, M1
Murohara, T1
Nagata, K1
Bauersachs, J1
Toto, R1
Huby, AC1
Antonova, G1
Groenendyk, J1
Gomez-Sanchez, CE1
Bollag, WB1
Filosa, JA1
Belin de Chantemèle, EJ1
Peng, W1
Ao, X1
Dai, H1
Yuan, L1
Huang, X1
Zhou, Q1
Cannavo, A1
Liccardo, D1
Eguchi, A1
Elliott, KJ1
Traynham, CJ1
Ibetti, J1
Eguchi, S1
Leosco, D1
Ferrara, N1
Rengo, G1
Koch, WJ1
Lother, A1
Hein, L1
Lasheen, NN1
Mohamed, GF1
Sechi, LA2
Novello, M1
Colussi, G2
Di Fabio, A1
Chiuch, A1
Nadalini, E1
Casanova-Borca, A1
Uzzau, A1
Catena, C2
Wu, R1
Zeng, Y1
Kawai, M1
Hongo, K1
Komukai, K1
Morimoto, S1
Nagai, M1
Seki, S1
Taniguchi, I1
Mochizuki, S1
Yoshimura, M1
Kubzansky, LD1
Adler, GK2
Cetrullo, S1
Facchini, A1
Stanic, I1
Tantini, B1
Pignatti, C1
Caldarera, CM1
Flamigni, F1
López, B1
González, A1
Díez, J1
Radović, M2
Damjanović, S1
Nale, D1
Mićić, S1
Vučović, D1
Nakajima, Y1
Yamada, M1
Taguchi, R1
Satoh, T1
Hashimoto, K1
Ozawa, A1
Shibusawa, N1
Okada, S1
Monden, T1
Mori, M1
Knier, B1
Cordasic, N1
Klanke, B1
Heusinger-Ribeiro, J1
Daniel, C1
Veelken, R1
Hartner, A1
Hilgers, KF1
Marzano, L1
Luther, JM1
Luo, P1
Wang, Z1
Cohen, SE1
Kim, HS1
Fogo, AB1
Brown, NJ1
Brem, AS1
Nagase, M1
Abad-Cardiel, M1
Alvarez-Álvarez, B1
Luque-Fernandez, L1
Fernández, C1
Fernández-Cruz, A1
Martell-Claros, N1
Firsov, D1
Muller, OG1
White, PC1
Pearce, D1
Bhargava, A1
Cole, TJ1
Fiebeler, A2
Haller, H1
Hostetter, TH1
Ibrahim, HN1
BUCHBORN, E3
KOCZOREK, KR3
KOHLER, M2
WOLFF, HP3
DI PERRI, T2
GUIDERI, R2
RAVENNI, G2
MONCIATTI, C1
BIANCHI, V2
SANDERS, LL1
MELBY, JC1
HANADA, M1
SAMBHI, MP1
VENNING, EH1
BECK, JC1
HALL, CE1
HALL, O1
Van Den Meiracker, AH1
Huizenga, AT1
Boomsma, F1
Mitka, M1
Nussberger, J1
Shagdarsuren, E1
Rong, S1
Hilfenhaus, G1
Al-Saadi, N1
Dechend, R1
Wellner, M1
Meiners, S1
Maser-Gluth, C1
Jeng, AY1
Webb, RL1
Luft, FC1
Muller, DN1
Sun, Y1
Weber, KT1
Lahera, V1
Cachofeiro, V1
Balfagon, G1
Rodicio, JL1
Giacchetti, G1
Ronconi, V1
Turchi, F1
Agostinelli, L1
Mantero, F1
Rilli, S1
Boscaro, M1
Kagiyama, S1
Matsumura, K1
Fukuhara, M1
Sakagami, K1
Fujii, K1
Iida, M1
Funder, JW1
Funck, RC1
Wilke, A1
Rupp, H1
Brilla, CG1
Lijnen, P1
Petrov, V1
Stowasser, M1
Martinez, DV1
Rocha, R1
Matsumura, M1
Oestreicher, E1
Ochoa-Maya, M1
Roubsanthisuk, W1
Knowlen, GG1
Kittleson, MD1
Nachreiner, RF1
Eyster, GE1
Zweifler, AJ1
Esler, M1
Shushliapin, OI1
Stimpel, M1
Kaufmann, W2
Wambach, G1
Grimaldi, A1
Pruszczynski, W1
Thervet, F1
Ardaillou, R1
Regan, TJ1
Pathan, A1
Weisse, AB1
Eaddy, C1
Torres, R1
Jayle, MF1
Legrand, JC1
Pasqualini, JR1
Cruz, IA1
Dillard, MG1
Hosten, AO1
Dioguardi, N1
Iimura, O2
Miyahara, M1
Kukuiri, T1
Abe, H1
Ueda, T1
Weil, MH1
Shubin, H1
Friedberg, CK1
Yoshida, H1
Mizukoshi, H1
Araki, Y1
Oelert, H1
Jick, H1
Müller, C2
Lutz, H2
Schmitz, W2
Reiss, F2
Ito, T1
Nakamura, K1
Kinouchi, T1
Kurosawa, T1
Oshima, M1
Manta, I1
Hodîrnău, A1
Proinov, I1
Băltescu, V1
Schneider, E1
Barbi, G1
Giocoli, G1
Cavina, G1
Sardini, D1
Vinogradov, AV1
Sycheva, IM1
Kiseleva, ZM1
Schaison, G1
Kinoshita, M1
Siegenthaler, W1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension[NCT05593055]Phase 475 participants (Anticipated)Interventional2023-08-25Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

27 reviews available for aldosterone and Heart Diseases

ArticleYear
MANAGEMENT OF ENDOCRINE DISEASE: The role of surgical adrenalectomy in primary aldosteronism.
    European journal of endocrinology, 2020, Volume: 183, Issue:6

    Topics: Adrenalectomy; Aldosterone; Endocrine System Diseases; Heart Diseases; Humans; Hyperaldosteronism; K

2020
Role of the vascular endothelial sodium channel activation in the genesis of pathologically increased cardiovascular stiffness.
    Cardiovascular research, 2022, 01-07, Volume: 118, Issue:1

    Topics: Aldosterone; Coronary Circulation; Coronary Vessels; Endothelial Cells; Epithelial Sodium Channels;

2022
Adrenal βarrestin1 targeting for tobacco-associated cardiac dysfunction treatment: Aldosterone production as the mechanistic link.
    Pharmacology research & perspectives, 2019, Volume: 7, Issue:4

    Topics: Adrenal Glands; Aldosterone; beta-Arrestin 1; Cotinine; Heart Diseases; Humans; Molecular Targeted T

2019
[Antifibrotic renal role of mineralcorticoid receptor antagonists].
    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2019, Jul-24, Volume: 36, Issue:4

    Topics: Aldosterone; Body Fluids; Cardiovascular Diseases; Clinical Trials as Topic; Cytokines; Diabetic Nep

2019
Aldosterone mediates cardiac fibrosis in the setting of hypertension.
    Current hypertension reports, 2013, Volume: 15, Issue:4

    Topics: Aldosterone; Angiotensin II; Animals; Cytochrome P-450 CYP11B2; Fibrosis; Heart Diseases; Humans; Hy

2013
Mineralocorticoid receptor activation and mineralocorticoid receptor antagonist treatment in cardiac and renal diseases.
    Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2

    Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aldosterone; Animals; Blood Pressure; Clinical Trials as Topi

2015
Vascular Mineralocorticoid Receptors: Linking Risk Factors, Hypertension, and Heart Disease.
    Hypertension (Dallas, Tex. : 1979), 2016, Volume: 68, Issue:1

    Topics: Aldosterone; Blood Vessels; Heart Diseases; Humans; Hypertension; Receptors, Mineralocorticoid; Risk

2016
Aldosterone: a forgotten mediator of the relationship between psychological stress and heart disease.
    Neuroscience and biobehavioral reviews, 2010, Volume: 34, Issue:1

    Topics: Aldosterone; Animals; Brain; Heart Diseases; Humans; Models, Biological; Stress, Psychological

2010
Aldosterone and the heart: from basic research to clinical evidence.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2012, Volume: 44, Issue:3

    Topics: Aldosterone; Animals; Heart; Heart Diseases; Humans; Hyperaldosteronism

2012
[Mineralocorticoid receptor: an update].
    Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70, Issue:9

    Topics: Aldosterone; Animals; Heart Diseases; Humans; Kidney Diseases; Mineralocorticoid Receptor Antagonist

2012
Aldosterone action in the heart.
    Pflugers Archiv : European journal of physiology, 2003, Volume: 446, Issue:3

    Topics: Aldosterone; Animals; Cardiovascular Physiological Phenomena; Heart; Heart Diseases; Humans

2003
Aldosterone: direct effects on and production by the heart.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:6

    Topics: Aldosterone; Animals; Cardiovascular Physiological Phenomena; Cytochrome P-450 CYP11B2; Electrophysi

2003
Aldosterone: its receptor, target genes, and actions.
    Vitamins and hormones, 2003, Volume: 66

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Animals; Brain; Chromatin; Epithelium; Gen

2003
Participation of the mineralocorticoid receptor in cardiac and vascular remodeling.
    Nephron. Physiology, 2003, Volume: 94, Issue:3

    Topics: Aldosterone; Animals; Heart Diseases; Humans; Kidney; Mice; Mineralocorticoid Receptor Antagonists;

2003
Aldosterone in chronic kidney and cardiac disease.
    Journal of the American Society of Nephrology : JASN, 2003, Volume: 14, Issue:9

    Topics: Aldosterone; Chronic Disease; Heart Diseases; Humans; Kidney Diseases

2003
[Profibrotic effects of aldosterone].
    Nederlands tijdschrift voor geneeskunde, 2004, Jul-31, Volume: 148, Issue:31

    Topics: Aldosterone; Animals; Fibrosis; Heart Diseases; Humans; Mineralocorticoid Receptor Antagonists; Myoc

2004
Aldosterone and its blockade: a cardiovascular and renal perspective.
    TheScientificWorldJournal, 2006, Apr-03, Volume: 6

    Topics: Aldosterone; Cardiovascular Physiological Phenomena; Heart Diseases; Humans; Kidney; Kidney Diseases

2006
Mineralocorticoid receptors and hypertension.
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 53, Issue:1-6

    Topics: Aldosterone; Animals; Epithelium; Heart Diseases; Hypertension; Rats; Receptors, Glucocorticoid; Rec

1995
Regulation and role of myocardial collagen matrix remodeling in hypertensive heart disease.
    Advances in experimental medicine and biology, 1997, Volume: 432

    Topics: Adult; Aldosterone; Angiotensin II; Animals; Cells, Cultured; Collagen; Collagenases; Heart; Heart D

1997
Induction of cardiac fibrosis by aldosterone.
    Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:6

    Topics: Aldosterone; Animals; Collagen; Fibroblasts; Fibrosis; Heart; Heart Diseases; Humans; Mineralocortic

2000
New perspectives on the role of aldosterone excess in cardiovascular disease.
    Clinical and experimental pharmacology & physiology, 2001, Volume: 28, Issue:10

    Topics: Aldosterone; Animals; Heart Diseases; Humans; Hyperaldosteronism

2001
[Recent data on the physiopathologic metabolism of aldosterone].
    Exposes annuels de biochimie medicale, 1967, Volume: 28

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Animals; Aorta; Edema; Female; Heart Disea

1967
[Heart diseases, hypertension and hormonal anomaly--with special reference to aldosterone and catecholamine].
    Naika. Internal medicine, 1967, Volume: 19, Issue:3

    Topics: Aldosterone; Catecholamines; Heart Diseases; Humans; Hypertension; Hyperthyroidism

1967
Shock following acute myocardial infarction. Current understanding of hemodynamic mechanisms.
    Progress in cardiovascular diseases, 1968, Volume: 11, Issue:1

    Topics: Acidosis; Aldosterone; Animals; Arrhythmias, Cardiac; Arteries; Blood Flow Velocity; Blood Pressure;

1968
Edema and pulmonary edema: pathologic physiology and differential diagnosis.
    Progress in cardiovascular diseases, 1971, Volume: 13, Issue:6

    Topics: Adrenal Glands; Aldosterone; Diagnosis, Differential; Edema; Extracellular Space; Female; Heart Dise

1971
[The third factor].
    Naika. Internal medicine, 1971, Volume: 28, Issue:1

    Topics: Aldosterone; Animals; Biological Assay; Dogs; Extracorporeal Circulation; Female; Glomerular Filtrat

1971
[Aldosterone and aldosterone antagonists in surgery].
    Der Anaesthesist, 1971, Volume: 20, Issue:6

    Topics: Adult; Aldosterone; Blood Volume; Brain Edema; Cardiac Surgical Procedures; Child; Digitalis Glycosi

1971

Trials

1 trial available for aldosterone and Heart Diseases

ArticleYear
Modulation of aldosterone release by epidural analgesia impacts brain natriuretic peptide: a link to stress cardiomyopathy? Pilot study.
    Clinical endocrinology, 2011, Volume: 74, Issue:5

    Topics: Aldosterone; Analgesia, Epidural; Anesthesia, General; Heart Diseases; Humans; Male; Middle Aged; Na

2011

Other Studies

56 other studies available for aldosterone and Heart Diseases

ArticleYear
Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway.
    International immunopharmacology, 2022, Volume: 113, Issue:Pt A

    Topics: Aldosterone; Animals; Cardio-Renal Syndrome; Eplerenone; Fibrosis; Heart Diseases; Macrophages; Myof

2022
Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway.
    International immunopharmacology, 2022, Volume: 113, Issue:Pt A

    Topics: Aldosterone; Animals; Cardio-Renal Syndrome; Eplerenone; Fibrosis; Heart Diseases; Macrophages; Myof

2022
Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway.
    International immunopharmacology, 2022, Volume: 113, Issue:Pt A

    Topics: Aldosterone; Animals; Cardio-Renal Syndrome; Eplerenone; Fibrosis; Heart Diseases; Macrophages; Myof

2022
Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway.
    International immunopharmacology, 2022, Volume: 113, Issue:Pt A

    Topics: Aldosterone; Animals; Cardio-Renal Syndrome; Eplerenone; Fibrosis; Heart Diseases; Macrophages; Myof

2022
Aldosterone: The Missing Cardiorenal Link.
    American journal of nephrology, 2019, Volume: 50, Issue:5

    Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Heart Diseases; Humans; Kidney Diseases; Mine

2019
Cardiac gluco- and mineralocorticoid receptors: From development to pathology.
    Annales d'endocrinologie, 2021, Volume: 82, Issue:3-4

    Topics: Aldosterone; Heart Diseases; Humans; Hydrocortisone; Receptors, Glucocorticoid; Receptors, Mineraloc

2021
Fabry disease patients have an increased risk of stroke in the COVID-19 ERA. A hypothesis.
    Medical hypotheses, 2020, Volume: 144

    Topics: Aldosterone; Angiotensin-Converting Enzyme 2; COVID-19; Endothelium, Vascular; Fabry Disease; Female

2020
Role and Regulation of MicroRNAs in Aldosterone-Mediated Cardiac Injury and Dysfunction in Male Rats.
    Endocrinology, 2017, 06-01, Volume: 158, Issue:6

    Topics: Aldosterone; Animals; Gene Expression Regulation; Heart; Heart Diseases; Hyperaldosteronism; Hyperte

2017
SB-216763, a GSK-3β inhibitor, protects against aldosterone-induced cardiac, and renal injury by activating autophagy.
    Journal of cellular biochemistry, 2018, Volume: 119, Issue:7

    Topics: Aldosterone; Animals; Autophagy; Cytokines; Fibrosis; Glycogen Synthase Kinase 3 beta; Heart Disease

2018
The Association of Life's Simple 7 with Aldosterone among African Americans in the Jackson Heart Study.
    Nutrients, 2019, Apr-26, Volume: 11, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Black or African American; Blood Glucose; Female; Heart

2019
Effects of salt status and blockade of mineralocorticoid receptors on aldosterone-induced cardiac injury.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2014, Volume: 37, Issue:2

    Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Diet, Sodium-Restricted; Echocardiography; Endoth

2014
Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis.
    Circulation, 2015, Dec-01, Volume: 132, Issue:22

    Topics: Adipocytes; Adrenal Cortex; Aldosterone; Animals; Cell Line, Tumor; Cells, Cultured; Endothelium, Va

2015
TAK-242, a Toll-Like Receptor 4 Antagonist, Protects against Aldosterone-Induced Cardiac and Renal Injury.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Acute Kidney Injury; Aldosterone; Animals; Cytokines; Heart Diseases; Hemodynamics; Inflammation; Ma

2015
Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases.
    Nature communications, 2016, Mar-02, Volume: 7

    Topics: Aldosterone; Animals; Arrestins; beta-Arrestins; Cell Culture Techniques; Cell Movement; G-Protein-C

2016
Possible mechanisms of cardiac contractile dysfunction and electrical changes in ammonium chloride induced chronic metabolic acidosis in Wistar rats.
    Physiological research, 2016, 12-13, Volume: 65, Issue:6

    Topics: Acidosis; Aldosterone; Ammonium Chloride; Animals; Chronic Disease; Echocardiography; Electrocardiog

2016
Relationship of plasma renin with a prothrombotic state in hypertension: relevance for organ damage.
    American journal of hypertension, 2008, Volume: 21, Issue:12

    Topics: Adult; Aldosterone; Algorithms; Analysis of Variance; Biomarkers; Cerebrovascular Disorders; Cross-S

2008
Does angiotensin II-aldosterone have a role in radiation-induced heart disease?
    Medical hypotheses, 2009, Volume: 72, Issue:3

    Topics: Aldosterone; Angiotensin II; Animals; Dose-Response Relationship, Radiation; Heart Diseases; Myocard

2009
Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2009, Volume: 32, Issue:7

    Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blood Vess

2009
Difluoromethylornithine inhibits hypertrophic, pro-fibrotic and pro-apoptotic actions of aldosterone in cardiac cells.
    Amino acids, 2010, Volume: 38, Issue:2

    Topics: Aldosterone; Animals; Apoptosis; Biogenic Polyamines; Cells, Cultured; Eflornithine; Fibrosis; Gene

2010
Circulating biomarkers of collagen metabolism in cardiac diseases.
    Circulation, 2010, Apr-13, Volume: 121, Issue:14

    Topics: Aldosterone; Biomarkers; Carrier Proteins; Collagen; Connective Tissue Growth Factor; Heart Diseases

2010
Cardiovascular complications of patients with aldosteronism associated with autonomous cortisol secretion.
    The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Circadian Rhythm; Cross-Sectional Studies; Female; Hear

2011
Effect of the plasminogen-plasmin system on hypertensive renal and cardiac damage.
    Journal of hypertension, 2011, Volume: 29, Issue:8

    Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Fibrinolysin; Fibrosis

2011
Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.
    Kidney international, 2012, Volume: 82, Issue:6

    Topics: Aldosterone; Angiotensin II; Animals; Aorta; Biomarkers; Blood Pressure; Cytochrome P-450 CYP11B2; D

2012
Targeting activated mineralocorticoid receptor: Occam's razor revisited.
    Kidney international, 2012, Volume: 82, Issue:6

    Topics: Aldosterone; Angiotensin II; Animals; Heart Diseases; Kidney Diseases; Mineralocorticoid Receptor An

2012
Hypertension caused by primary hyperaldosteronism: increased heart damage and cardiovascular risk.
    Revista espanola de cardiologia (English ed.), 2013, Volume: 66, Issue:1

    Topics: Aged; Aldosterone; Blood Pressure; Cardiovascular Diseases; Cohort Studies; Female; Heart Diseases;

2013
[Aldosterone activity and sodium retention in heart disease and its pathophysiologic significance].
    Klinische Wochenschrift, 1956, Nov-01, Volume: 34, Issue:41-42

    Topics: Aldosterone; Heart Diseases; Humans; Hypernatremia; Ions; Sodium; Sodium, Dietary

1956
[Aldosterone activity and sodium retention in heart disease and its pathophysiologic significance].
    Klinische Wochenschrift, 1956, Nov-01, Volume: 34, Issue:41-42

    Topics: Aldosterone; Heart Diseases; Humans; Hypernatremia; Ions; Sodium; Sodium, Dietary

1956
[Aldosterone activity and sodium retention in heart disease and its pathophysiologic significance].
    Klinische Wochenschrift, 1956, Nov-01, Volume: 34, Issue:41-42

    Topics: Aldosterone; Heart Diseases; Humans; Hypernatremia; Ions; Sodium; Sodium, Dietary

1956
[Aldosterone activity and sodium retention in heart disease and its pathophysiologic significance].
    Klinische Wochenschrift, 1956, Nov-01, Volume: 34, Issue:41-42

    Topics: Aldosterone; Heart Diseases; Humans; Hypernatremia; Ions; Sodium; Sodium, Dietary

1956
Hyperaldosteronism in heart disease.
    Lancet (London, England), 1957, Jul-13, Volume: 273, Issue:6985

    Topics: Aldosterone; Heart Diseases; Heart Failure; Humans; Hyperaldosteronism

1957
[The pathogenesis of nyctohemeral variations in urinary aldosterone and in the elimination of water and sodium in heart disease patients].
    Bollettino della Societa italiana di biologia sperimentale, 1958, Jul-31, Volume: 34, Issue:14

    Topics: Aldosterone; Biological Transport; Heart Diseases; Humans; Ions; Sodium; Sodium, Dietary; Water

1958
[Nocturnal urination of cardiac patients; study of the pathogenesis as a function of aldosterone secretion].
    Acta cardiologica, 1959, Volume: 14, Issue:1

    Topics: Aldosterone; Heart Diseases; Humans; Posture; Urination

1959
ALDOSTERONE AND THE EDEMA OF CONGESTIVE HEART FAILURE.
    Archives of internal medicine, 1964, Volume: 113

    Topics: Aldosterone; Chromatography; Diuretics; Edema; Geriatrics; Heart Diseases; Heart Failure; Hypertensi

1964
[ALDOSTERONE SECRETION RATE IN VARIOUS DISEASES].
    [Nisshin igaku] The Japanese journal of medical progress, 1963, Volume: 50

    Topics: Aldosterone; Cushing Syndrome; Diabetic Nephropathies; Heart Diseases; Humans; Hyperaldosteronism; H

1963
ALDOSTERONE SECRETION RATE AND ELECTROLYTE BALANCE STUDIES ON THREE PATIENTS WITH HYPERTENSION. INFLUENCE OF GUANETHIDINE, HYDRALAZINE AND METHYCLOTHIAZIDE.
    Metabolism: clinical and experimental, 1964, Volume: 13

    Topics: Aldosterone; Diet, Sodium-Restricted; Diuretics; Guanethidine; Heart Diseases; Humans; Hydralazine;

1964
HYPERTENSION AND HYPERSALIMENTATION. I. ALDOSTERONE HYPERTENSION.
    Laboratory investigation; a journal of technical methods and pathology, 1965, Volume: 14

    Topics: Adrenal Glands; Aldosterone; Arteritis; Diet; Heart Diseases; Hypertension; Kidney; Metabolism; Myoc

1965
Scientists probe aldosterone's role in hypertension and heart disease.
    JAMA, 2004, Dec-08, Volume: 292, Issue:22

    Topics: Aldosterone; Cardiovascular Agents; Cardiovascular Physiological Phenomena; Heart Diseases; Humans;

2004
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
    Circulation, 2005, Jun-14, Volume: 111, Issue:23

    Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Angiotensin II; Angiotensinogen; Animals; Animals, Genet

2005
Animal models of cardiac fibrosis.
    Methods in molecular medicine, 2005, Volume: 117

    Topics: Aldosterone; Angiotensin II; Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Diseases;

2005
Aldosterone as a key mediator of the cardiometabolic syndrome in primary aldosteronism: an observational study.
    Journal of hypertension, 2007, Volume: 25, Issue:1

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aldosterone; Antihypertensive Agents; Blood Glucose

2007
Aldosterone-and-salt-induced cardiac fibrosis is independent from angiotensin II type 1a receptor signaling in mice.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2007, Volume: 30, Issue:10

    Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Blotting, Western; Ca

2007
Cardiac damage prevention by eplerenone: comparison with low sodium diet or potassium loading.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 39, Issue:2 Pt 2

    Topics: Aldosterone; Angiotensin II; Animals; Diet, Sodium-Restricted; Disease Models, Animal; Eplerenone; H

2002
Comparison of plasma aldosterone concentration among clinical status groups of dogs with chronic heart failure.
    Journal of the American Veterinary Medical Association, 1983, Nov-01, Volume: 183, Issue:9

    Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril;

1983
Factors influencing the choice of antihypertensive agents.
    Postgraduate medicine, 1976, Volume: 60, Issue:7

    Topics: Age Factors; Aldosterone; Cerebrovascular Disorders; Clonidine; Depression; Diabetes Complications;

1976
[Change of certain humoral and hemodynamic factors in chronic circulatory insufficiency].
    Klinicheskaia meditsina, 1975, Volume: 53, Issue:7

    Topics: Aldosterone; Blood Circulation; Female; Heart Diseases; Hemodynamics; Humans; Male; Renin

1975
A symposium: International update--the important role of aldosterone and aldosterone antagonism in cardiovascular medicine. Based on symposia held in Brussels, Belgium and Newport Beach, California.
    The American journal of cardiology, 1990, Jun-19, Volume: 65, Issue:23

    Topics: Aldosterone; Heart Diseases; Humans; Hypertension; Mineralocorticoid Receptor Antagonists

1990
[Atrial natriuretic peptide (ANP) in essential hypertension: a humoral marker for salt sensitivity and hypertensive heart disease at a clinically asymptomatic stage?].
    Zeitschrift fur Kardiologie, 1988, Volume: 77 Suppl 2

    Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Catecholamines; Female; Heart Disease

1988
Antidiuretic hormone response to volume depletion in diabetic patients with cardiac autonomic dysfunction.
    Clinical science (London, England : 1979), 1985, Volume: 68, Issue:5

    Topics: Adult; Aldosterone; Autonomic Nervous System Diseases; Blood Pressure; Blood Volume; Diabetic Neurop

1985
The contribution of arterial pressure to the cardiac dysfunction of chronic alcoholism.
    Acta medica Scandinavica. Supplementum, 1985, Volume: 703

    Topics: Adult; Alcoholism; Aldosterone; Blood Pressure; Catecholamines; Echocardiography; Electrolytes; Hear

1985
Selective hypoaldosteronism: a case report and review of literature.
    The Medical annals of the District of Columbia, 1974, Volume: 43, Issue:12

    Topics: Adrenal Insufficiency; Adult; Aldosterone; Diabetes Complications; Heart Diseases; Humans; Hyperkale

1974
[Edema in the patient with heart disease].
    Minerva medica, 1973, Jan-17, Volume: 64, Issue:3

    Topics: Aldosterone; Blood Pressure; Edema; Glomerular Filtration Rate; Heart Diseases; Heart Failure; Human

1973
Actual incidence of secondary hypertension.
    Japanese circulation journal, 1973, Volume: 37, Issue:9

    Topics: Adult; Aldosterone; Biopsy; Blood Pressure; Catecholamines; Cushing Syndrome; Diagnosis, Differentia

1973
The use of glucocorticoids for diuresis in patients with fluid retention not resulting from renal disease.
    Annals of the New York Academy of Sciences, 1966, Nov-22, Volume: 139, Issue:2

    Topics: Aldosterone; Chlorothiazide; Diuresis; Edema; Glomerular Filtration Rate; Glucocorticoids; Heart Dis

1966
[Electrolyte changes in heart surgery with autogenous blood dilution perfusions].
    Thoraxchirurgie, vaskulare Chirurgie, 1968, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Aldosterone; Child; Erythrocytes; Extracorporeal Circulation; Heart Defects, Cong

1968
The role of aldosterone in the pathogenesis of congestive heart failure.
    Japanese heart journal, 1967, Volume: 8, Issue:3

    Topics: Aldosterone; Animals; Dogs; Edema; Female; Heart Diseases; Heart Failure; Humans; Mannitol; Potassiu

1967
[Research on arterial hypertension. Significance of aldosterone, catecholamines, amino acids and some electrolytes in compensated and decompensated cardiac lesions].
    Medicina interna, 1970, Volume: 22, Issue:7

    Topics: Adult; Aged; Aldosterone; Amino Acids; Catecholamines; Coronary Disease; Electrolytes; Female; Heart

1970
[Clinical evaluation of a new method for the determination of urinary aldosterone].
    Minerva medica, 1971, Jul-28, Volume: 62, Issue:59

    Topics: Aldosterone; Chromatography, Thin Layer; Edema; Female; Heart Diseases; Humans; Hyperaldosteronism;

1971
[The significance of aldosterone in the pathogenesis of edema in cardiac insufficiency].
    Kardiologiia, 1967, Volume: 7, Issue:4

    Topics: Adult; Aged; Aldosterone; Edema; Female; Heart Diseases; Heart Failure; Humans; Male; Middle Aged; P

1967
[Physiopathology and treatment of hyponatremia (II)].
    La Presse medicale, 1968, May-18, Volume: 76, Issue:24

    Topics: Adrenal Insufficiency; Aldosterone; Anesthesia; Diuretics; Heart Diseases; Humans; Hyperpituitarism;

1968
[Electrolyte changes in heart surgery with autogenous blood dilution perfusions].
    Zeitschrift fur Tropenmedizin und Parasitologie, 1968, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Aldosterone; Child; Erythrocytes; Extracorporeal Circulation; Heart Defects, Cong

1968
Studies on cardiac output to blood volume, and renal circulation in chronic congestive heart failure.
    Japanese circulation journal, 1968, Volume: 32, Issue:3

    Topics: Adult; Aged; Aldosterone; Arteriosclerosis; Blood Pressure; Blood Volume; Cardiac Output; Chronic Di

1968
[Diuretic therapy of hydropic cardiac insufficiency].
    Deutsche medizinische Wochenschrift (1946), 1965, Dec-10, Volume: 90, Issue:50

    Topics: Aldosterone; Diuretics; Edema; Heart Diseases; Humans; Sulfonamides; Sympatholytics

1965