aldosterone has been researched along with Heart Disease, Ischemic in 22 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aldosterone escape was defined as plasma levels of aldosterone above the normal range in our laboratory (> 0." | 5.31 | Relation of aldosterone "escape" despite angiotensin-converting enzyme inhibitor administration to impaired exercise capacity in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Caruso, B; Cicoira, M; Franceschini, L; Golia, G; Rossi, A; Zanolla, L; Zardini, P; Zeni, P, 2002) |
| "Aldosterone blockade has been shown to reduce the incidence of sudden death in patients with heart failure." | 2.73 | Spironolactone has antiarrhythmic activity in ischaemic cardiac patients without cardiac failure. ( Donnan, PT; Pringle, SD; Shah, NC; Struthers, AD, 2007) |
| "Heart failure is associated with many comorbidities and among them, cancer has stood out as a contributor of death in these patients." | 2.72 | RAAS: A Convergent Player in Ischemic Heart Failure and Cancer. ( Cambrón-Mora, D; Garcia-Garduño, TC; Padilla-Gutierrez, JR; Valle, Y, 2021) |
| "Aldosterone promotes sodium and water retention, sympathoadrenergic activation, endothelial dysfunction, and cardiovascular fibrosis and hypertrophy." | 2.42 | Mineralocorticoid receptor antagonism and cardiac remodeling in ischemic heart failure. ( Bauersachs, J; Fraccarollo, D; Galuppo, P, 2004) |
| "Aldosterone production plays an important role in the remodeling of the heart." | 2.41 | Molecular mechanisms of myocardial remodeling. The role of aldosterone. ( Delcayre, C; Swynghedauw, B, 2002) |
| "Primary aldosteronism is the most frequent endocrine cause of secondary hypertension." | 1.42 | Primary aldosteronism and its various clinical scenarios. ( Abad-Cardiel, M; Alvarez-Alvarez, B; García-Donaire, JA; Martell-Claros, N; Pérez, CF, 2015) |
| "Aldosterone escape was defined as plasma levels of aldosterone above the normal range in our laboratory (> 0." | 1.31 | Relation of aldosterone "escape" despite angiotensin-converting enzyme inhibitor administration to impaired exercise capacity in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Caruso, B; Cicoira, M; Franceschini, L; Golia, G; Rossi, A; Zanolla, L; Zardini, P; Zeni, P, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 15 (68.18) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Garcia-Garduño, TC | 1 |
| Padilla-Gutierrez, JR | 1 |
| Cambrón-Mora, D | 1 |
| Valle, Y | 1 |
| Martell-Claros, N | 1 |
| Abad-Cardiel, M | 1 |
| Alvarez-Alvarez, B | 1 |
| García-Donaire, JA | 1 |
| Pérez, CF | 1 |
| Klotz, S | 1 |
| Burkhoff, D | 1 |
| Garrelds, IM | 2 |
| Boomsma, F | 1 |
| Danser, AH | 2 |
| Mill, JG | 1 |
| Stefanon, I | 1 |
| dos Santos, L | 1 |
| Baldo, MP | 1 |
| Delcayre, C | 1 |
| Swynghedauw, B | 1 |
| Strametz-Juranek, J | 1 |
| Pacher, R | 1 |
| Kos, T | 1 |
| Woloszczuk, W | 1 |
| Grimm, M | 1 |
| Zuckermann, A | 1 |
| Stanek, B | 1 |
| Huang, Y | 1 |
| Hunyor, SN | 1 |
| Jiang, L | 1 |
| Kawaguchi, O | 1 |
| Shirota, K | 1 |
| Ikeda, Y | 1 |
| Yuasa, T | 1 |
| Gallagher, G | 1 |
| Zeng, B | 1 |
| Zheng, X | 1 |
| Fraccarollo, D | 1 |
| Galuppo, P | 1 |
| Bauersachs, J | 1 |
| Weber, KT | 2 |
| Jaffe, IZ | 1 |
| Mendelsohn, ME | 1 |
| Fujita, M | 1 |
| Minamino, T | 1 |
| Asanuma, H | 1 |
| Sanada, S | 1 |
| Hirata, A | 1 |
| Wakeno, M | 1 |
| Myoishi, M | 1 |
| Okuda, H | 1 |
| Ogai, A | 1 |
| Okada, K | 1 |
| Tsukamoto, O | 1 |
| Koyama, H | 1 |
| Hori, M | 1 |
| Kitakaze, M | 1 |
| Wehling, M | 1 |
| Ishikawa, C | 1 |
| Tsutamoto, T | 1 |
| Wada, A | 1 |
| Fujii, M | 1 |
| Ohno, K | 1 |
| Sakai, H | 1 |
| Yamamoto, T | 1 |
| Horie, M | 1 |
| De Feo, S | 1 |
| Franceschini, L | 2 |
| Brighetti, G | 1 |
| Cicoira, M | 2 |
| Zanolla, L | 2 |
| Rossi, A | 2 |
| Golia, G | 2 |
| Zardini, P | 2 |
| Chai, W | 1 |
| de Vries, R | 1 |
| Shah, NC | 1 |
| Pringle, SD | 1 |
| Donnan, PT | 1 |
| Struthers, AD | 1 |
| Mitrovic, V | 1 |
| Oehm, E | 1 |
| Minge, C | 1 |
| Thürmann, P | 1 |
| Schlepper, M | 1 |
| Park, JW | 1 |
| Heinzler, R | 1 |
| Wirtz, JH | 1 |
| Fieten-Rumswinkel, M | 1 |
| Braun, P | 1 |
| May, E | 1 |
| Hetzer, R | 1 |
| Heinrich, KW | 1 |
| O'Leary, E | 1 |
| Hubbard, K | 1 |
| Tormey, W | 1 |
| Cunningham, AJ | 1 |
| Sun, Y | 1 |
| Cleutjens, JP | 1 |
| Guo, H | 1 |
| Lu, D | 1 |
| Wang, J | 1 |
| He, H | 1 |
| Zhou, B | 1 |
| Jiang, C | 1 |
| Zeni, P | 1 |
| Caruso, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension[NCT05593055] | Phase 4 | 75 participants (Anticipated) | Interventional | 2023-08-25 | Recruiting | ||
| Evaluation of Low Pressure Pneumoperitoneum in Bariatric Surgery: A Prospective Randomized Study[NCT03179111] | 94 participants (Actual) | Interventional | 2017-08-30 | Completed | |||
| [NCT02324478] | 52 participants (Anticipated) | Observational | 2015-03-31 | Completed | |||
| Exercise Intolerance in Elderly Diastolic Heart Failure[NCT00123955] | Phase 3 | 80 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Left ventricle measurements by MRI:~Mass/end diastolic volume ratio: g/ml" (NCT00123955)
Timeframe: Baseline, 9 month
| Intervention | g/ml (Mean) | |
|---|---|---|
| baseline | 9 month | |
| Placebo | 1.7 | 1.6 |
| Spironolactone | 1.8 | 1.7 |
Peak exercise VO2 (NCT00123955)
Timeframe: Baseline, 4 and 9 months
| Intervention | ml/kg/min (Mean) | ||
|---|---|---|---|
| Baseline | 4 months | 9 months | |
| Placebo | 13.3 | 13.5 | 13.9 |
| Spironolactone | 13.5 | 13.6 | 13.8 |
"Echocardiography Doppler measurement of left ventricular diastolic function:~Early mitral annulus velocity (lateral) (Ea; cm/s)" (NCT00123955)
Timeframe: Baseline, 4 month and 9 month
| Intervention | cm/s (Mean) | ||
|---|---|---|---|
| baseline | 4 month | 9 month | |
| Placebo | 6.8 | 6.8 | 6.6 |
| Spironolactone | 7.0 | 7.0 | 7.4 |
"The Minnesota Living with Heart Failure Questionnaire (MLHF) is a self-administered disease-specific questionnaire for patients with Heart Failure, comprising 21 items rated on six-point Likert scales, representing different degrees of impact of HF on HRQoL, from 0 (none) to 5 (very much). It provides a total score (range 0-105, from best to worst HRQoL), as well as scores for two dimensions, physical (8 items, range 0-40) and emotional (5 items, range 0-25). The other eight items (of the total of 21) are only considered for the calculation of the total score.~Scale of 0-105:The higher the score the worse the heart failure related Quality of Life." (NCT00123955)
Timeframe: Baseline, 4 and 9 months
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Baseline | 4 months | Final- 9 months | |
| Placebo | 28 | 29 | 25 |
| Spironolactone | 32 | 29 | 29 |
5 reviews available for aldosterone and Heart Disease, Ischemic
| Article | Year |
|---|---|
RAAS: A Convergent Player in Ischemic Heart Failure and Cancer.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Heart Failure; Humans; Myocar | 2021 |
Remodeling in the ischemic heart: the stepwise progression for heart failure.
Topics: Adrenergic Neurons; Aldosterone; Angiotensins; Apoptosis; Arrhythmias, Cardiac; Heart; Heart Failure | 2011 |
Molecular mechanisms of myocardial remodeling. The role of aldosterone.
Topics: Aldosterone; Animals; Cardiomyopathies; Female; Fibrosis; Heart Failure; Humans; Mice; Mice, Transge | 2002 |
Mineralocorticoid receptor antagonism and cardiac remodeling in ischemic heart failure.
Topics: Aldosterone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Myocardial Ischemia; Myo | 2004 |
Structural remodeling of the infarcted rat heart.
Topics: Aldosterone; Angiotensin II; Animals; Collagen; Fibrosis; Humans; Metalloendopeptidases; Myocardial | 1996 |
3 trials available for aldosterone and Heart Disease, Ischemic
| Article | Year |
|---|---|
Inhibition of aldosterone and endothelin-1 by carperitide was attenuated with more than 1 week of infusion in patients with congestive heart failure.
Topics: Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Cardiomyopathy, Dilated; Chronic Disease; Cy | 2005 |
Spironolactone has antiarrhythmic activity in ischaemic cardiac patients without cardiac failure.
Topics: Aged; Aldosterone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cross-Over Studies; Double-Blind Me | 2007 |
[Anti-ischemia effects of gallopamil and esmolol in an intra-individual comparison in patients with coronary heart disease].
Topics: Adrenergic beta-Antagonists; Aged; Aldosterone; Atrial Natriuretic Factor; Coronary Angiography; Cor | 1994 |
14 other studies available for aldosterone and Heart Disease, Ischemic
| Article | Year |
|---|---|
Primary aldosteronism and its various clinical scenarios.
Topics: Adult; Aged; Aldosterone; Cardiovascular Diseases; Female; Humans; Hyperaldosteronism; Hypertension; | 2015 |
The impact of left ventricular assist device-induced left ventricular unloading on the myocardial renin-angiotensin-aldosterone system: therapeutic consequences?
Topics: Adolescent; Adult; Aged; Aldosterone; Blood Pressure; Female; Heart Failure; Heart Transplantation; | 2009 |
Sequential big endothelin plasma levels in heart transplant recipients during bridging therapy and after successful heart transplantation.
Topics: Aged; Aldosterone; Atrial Natriuretic Factor; Austria; Biomarkers; Blood Urea Nitrogen; Creatinine; | 2003 |
Remodeling of the chronic severely failing ischemic sheep heart after coronary microembolization: functional, energetic, structural, and cellular responses.
Topics: Aldosterone; Angiotensin II; Animals; Atrial Natriuretic Factor; Caspase 2; Caspase 3; Caspase 8; Ca | 2004 |
The neuroendocrine-immune interface gone awry in aldosteronism.
Topics: Aldosterone; Animals; Central Nervous System; Heart Failure; Humans; Hyperaldosteronism; Kidney; Min | 2004 |
Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Adenoviridae; Aldosterone; Angiotensin II; Angiotensin | 2005 |
Aldosterone nongenomically worsens ischemia via protein kinase C-dependent pathways in hypoperfused canine hearts.
Topics: Aldosterone; Animals; Coronary Circulation; Coronary Vessels; Dogs; Enzyme Activation; Heart; Hemody | 2005 |
Rapid effects of aldosterone: relevant in cardiac ischemia?
Topics: Aldosterone; Animals; Humans; Myocardial Ischemia; Time Factors | 2005 |
Ischemic etiology of heart failure identifies patients with more severely impaired exercise capacity.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Blood Flow Velocity; Blood Pressure; Echocardiography; | 2005 |
Cardioprotective effects of eplerenone in the rat heart: interaction with locally synthesized or blood-derived aldosterone?
Topics: Aldosterone; Animals; Cardiotonic Agents; Drug Interactions; Eplerenone; Heart; Hemodynamics; In Vit | 2006 |
Low-dose enoximone therapy in pre-transplant patients: hemodynamic, echocardiographic, and neurohumoral findings.
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Combined Modality Therapy; Dose-Response Relationship | 1994 |
Laparoscopic cholecystectomy: haemodynamic and neuroendocrine responses after pneumoperitoneum and changes in position.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Cholecystectomy, Laparoscopic; Electrocardiography, Ambula | 1996 |
Laparoscopic cholecystectomy: haemodynamic and neuroendocrine responses after pneumoperitoneum and changes in position.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Cholecystectomy, Laparoscopic; Electrocardiography, Ambula | 1996 |
Laparoscopic cholecystectomy: haemodynamic and neuroendocrine responses after pneumoperitoneum and changes in position.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Cholecystectomy, Laparoscopic; Electrocardiography, Ambula | 1996 |
Laparoscopic cholecystectomy: haemodynamic and neuroendocrine responses after pneumoperitoneum and changes in position.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Cholecystectomy, Laparoscopic; Electrocardiography, Ambula | 1996 |
[Study on the relation between hypertensive left ventricular hypertrophy in very old people with neurohormonal factors and ventricular arrhythmias].
Topics: Aged; Aged, 80 and over; Aldosterone; Angiotensin II; Arrhythmias, Cardiac; Female; Humans; Hyperten | 2000 |
Relation of aldosterone "escape" despite angiotensin-converting enzyme inhibitor administration to impaired exercise capacity in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
Topics: Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Cardiomyopathy, Dilated; Chronic Diseas | 2002 |