aldosterone and Heart Arrest studies

Heart Arrest: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.

Research Excerpts

Excerpt	Relevance	Reference
"To address this question, we examined data from the dal-OUTCOMES trial that compared the cholesteryl ester transfer protein inhibitor dalcetrapib with placebo, beginning 4 to 12 weeks after an index acute coronary syndrome."	7.85	Aldosterone Does Not Predict Cardiovascular Events Following Acute Coronary Syndrome in Patients Initially Without Heart Failure. ( Ballantyne, CM; Barter, PJ; Gunzburger, E; Kallend, D; Kittelson, J; Leiter, LA; Leitersdorf, E; McMurray, JJ; Nicholls, SJ; Olsson, AG; Pitts, R; Schwartz, GG; Shah, PK; Tardif, JC, 2017)
"To address this question, we examined data from the dal-OUTCOMES trial that compared the cholesteryl ester transfer protein inhibitor dalcetrapib with placebo, beginning 4 to 12 weeks after an index acute coronary syndrome."	3.85	Aldosterone Does Not Predict Cardiovascular Events Following Acute Coronary Syndrome in Patients Initially Without Heart Failure. ( Ballantyne, CM; Barter, PJ; Gunzburger, E; Kallend, D; Kittelson, J; Leiter, LA; Leitersdorf, E; McMurray, JJ; Nicholls, SJ; Olsson, AG; Pitts, R; Schwartz, GG; Shah, PK; Tardif, JC, 2017)
"At 1 and 3 mins after cardiac arrest, the control group exhibited significant increases of epinephrine and norepinephrine concentrations (p < ."	1.30	Impaired neuroendocrine response mediates refractoriness to cardiopulmonary resuscitation in spinal anesthesia. ( Cryer, PE; Gomez-Sanchez, CE; Rosenberg, JM; Wahr, JA; Wortsman, J, 1998)

Research

Studies (4)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Change From Baseline for HDL Cholesterol

Composite Endpoint:All Cause Mortality

Incidence of Cardiovascular Mortality and Morbidity

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (50.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Pitts, R	1
Gunzburger, E	1
Ballantyne, CM	1
Barter, PJ	1
Kallend, D	1
Leiter, LA	1
Leitersdorf, E	1
Nicholls, SJ	1
Shah, PK	1
Tardif, JC	1
Olsson, AG	1
McMurray, JJ	1
Kittelson, J	1
Schwartz, GG	1
Struthers, AD	1
Tenedieva, VD	1
Kulikovsky, VP	1
Lyamin, PV	1
Nepomnyaschi, VP	1
Rosenberg, JM	1
Wortsman, J	1
Wahr, JA	1
Cryer, PE	1
Gomez-Sanchez, CE	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized, Double-blind, Placebo-controlled Study Assessing the Effect of RO4607381 on Cardiovascular Mortality and Morbidity in Clinically Stable Patients With a Recent Acute Coronary Syndrome[NCT00658515]	Phase 3	15,871 participants (Actual)	Interventional	2008-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	mg/dL (Least Squares Mean)
Dalcetrapib (RO4607381)	44.96
Placebo	15.60

Intervention	Participants (Count of Participants)
Dalcetrapib (RO4607381)	226
Placebo	229

Number of cardiovascular events per patient per year (NCT00658515)
Timeframe: From date of randomization to first event up to 48 months

Article	Year
Aldosterone Does Not Predict Cardiovascular Events Following Acute Coronary Syndrome in Patients Initially Without Heart Failure. Journal of the American Heart Association, 2017, 01-10, Volume: 6, Issue:1 Topics: Acute Coronary Syndrome; Aged; Aldosterone; Amides; Angina, Unstable; Anticholesteremic Agents; Card	2017
The CSF aldosterone in brain tumors with brain edema. Acta neurochirurgica. Supplementum, 1994, Volume: 60 Topics: Adolescent; Adult; Aged; Aldosterone; Astrocytoma; Blood-Brain Barrier; Brain Edema; Brain Neoplasms	1994
Impaired neuroendocrine response mediates refractoriness to cardiopulmonary resuscitation in spinal anesthesia. Critical care medicine, 1998, Volume: 26, Issue:3 Topics: Adrenal Glands; Aldosterone; Anesthesia, Spinal; Animals; Cardiopulmonary Resuscitation; Dogs; Epine	1998

aldosterone and Heart Arrest