Page last updated: 2024-11-07

aldosterone and HIV Coinfection

aldosterone has been researched along with HIV Coinfection in 11 studies

Research Excerpts

Excerpt	Relevance	Reference
" This abnormality, which leads to the development of hyperkalemia after the L-arginine challenge, may be related, in part, to a failure in the aldosterone response to hyperkalemia."	3.70	Hyperkalemia in patients infected with the human immunodeficiency virus: involvement of a systemic mechanism. ( Alcazar, JM; Bello, E; Caramelo, C; Casado, S; Fernández Guerrero, M; Gazapo, RM; Martell, N; Rovira, A; Ruilope, LM; Ruiz, E, 1999)
"Adrenal insufficiency has been reported among critically ill HIV-infected patients."	1.34	Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus. ( Arregger, A; Burgos, M; Cardoso, E; Contreras, LN; González, N; Molina, A; Persi, G; Rodríguez, V; Tumilasci, O, 2007)

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (27.27)	18.2507
2000's	2 (18.18)	29.6817
2010's	4 (36.36)	24.3611
2020's	2 (18.18)	2.80

Authors

Authors	Studies
Shen, G	1
Thomas, TS	2
Walpert, AR	1
McClure, CM	1
Fitch, KV	2
deFilippi, C	1
Torriani, M	2
Buckless, CG	1
Adler, GK	4
Grinspoon, SK	5
Srinivasa, S	3
Feldpausch, MN	1
Wong, K	1
Mayhew, C	1
Stanley, T	1
Lo, J	3
Wen, Y	1
Ding, HB	1
Chen, W	1
Zhou, Y	1
Wang, W	1
Wang, Y	1
Lu, X	1
Liu, J	1
Kang, J	1
Geng, W	1
Shang, H	1
Liu, P	1
Looby, SE	1
Wei, J	1
Montes-de-Oca, M	1
Blanco, MJ	1
Marquez, M	1
Soto, MJ	1
Fernandez-Gutiérrez, C	1
Rodriguez-Ramos, C	1
Giron-Gonzalez, JA	1
Cardoso, E	1
Persi, G	1
González, N	1
Tumilasci, O	1
Arregger, A	1
Burgos, M	1
Rodríguez, V	1
Molina, A	1
Contreras, LN	1
Schürmeyer, TH	1
Müller, V	1
von zur Mühlen, A	1
Schmidt, RE	1
Caramelo, C	1
Bello, E	1
Ruiz, E	1
Rovira, A	1
Gazapo, RM	1
Alcazar, JM	1
Martell, N	1
Ruilope, LM	1
Casado, S	1
Fernández Guerrero, M	1
Oberfield, SE	1
Kairam, R	1
Bakshi, S	1
Bamji, M	1
Bhushan, V	1
Mayes, D	1
Levine, LS	1

Clinical Trials (3)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Ending Subclinical Heart Failure Using an Aldosterone and Natriuretic Peptide Targeted Treatment in HIV--The ENCHANTMENT HIV Study[NCT04153136]	Phase 2	50 participants (Anticipated)	Interventional	2020-09-11	Recruiting
Mineralocorticoid Receptor Antagonism for Cardiovascular Health in HIV--The MIRACLE HIV Study[NCT02740179]		40 participants (Actual)	Interventional	2017-01-31	Completed
Physiologic Investigation of the Renin Angiotensin Aldosterone Axis in HIV[NCT01407237]		30 participants (Actual)	Observational	2012-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Arterial Inflammation

Percentage change (value at 12 months minus value at baseline) in target to background ratio (a measure of arterial inflammation) of the index vessel measured via positron emission tomography/computed tomography (NCT02740179)
Timeframe: 12 Months

Intervention	percentage change (Median)
Eplerenone	-12.4
Placebo	5.1

Assessment of Cardiac Diastolic Function Via Cardiac Imaging

Change (value at 12 months minus value at baseline) in left ventricular end diastolic volume on cardiac magnetic resonance imaging (NCT02740179)
Timeframe: 12 Months

Intervention	mL (Mean)
Eplerenone	-13
Placebo	10

Assessment of Cardiac Structure by Left Ventricular Mass on Cardiac Imaging

Change (value at 12 months minus value at baseline) in left ventricular mass on cardiac magnetic resonance imaging (NCT02740179)
Timeframe: 12 Months

Intervention	g (Median)
Eplerenone	1
Placebo	9

Assessment of Cardiac Systolic Function Via Cardiac Imaging

Change (value at 12 months minus value at baseline) in global circumferential strain (GCS) on cardiac magnetic resonance imaging (NCT02740179)
Timeframe: 12 Months

Intervention	percentage GCS (Median)
Eplerenone	-1.3
Placebo	2.3

Coronary Plaque

Change (value at 12 months minus value at baseline) in coronary plaque measured via coronary computed tomography angiogram assessed by coronary calcium score Scale: minimum 0 to maximum no limit, higher score indicates more plaque (NCT02740179)
Timeframe: 12 Months

Intervention	score on a scale (Median)
Eplerenone	0
Placebo	5

Markers of Arterial Inflammation

Change (value at 12 months minus value at baseline) in plasma LpPLA2 (NCT02740179)
Timeframe: 12 Months

Intervention	ng/mL (Median)
Eplerenone	3.0
Placebo	2.6

Markers of Fibrosis

Change (value at 12 months minus value at baseline) in myocardial fibrosis measured by T1 (a signal intensity that measures fibrosis) via cardiac magnetic resonance imaging (NCT02740179)
Timeframe: 12 Months

Intervention	ms (Median)
Eplerenone	25
Placebo	1

Markers of Immune Activation MCP-1

Change (value at 12 months minus value at baseline) in plasma MCP-1 (NCT02740179)
Timeframe: 12 Months

Intervention	pg/mL (Median)
Eplerenone	285
Placebo	292

Markers of Immune Activation sCD163

Change (value at 12 months minus value at baseline) in plasma sCD163 (NCT02740179)
Timeframe: 12 Months

Intervention	ng/mL (Median)
Eplerenone	-275
Placebo	-160

Markers of Subclinical Injury

Change (value at 12 months minus value at baseline) in serum NT-proBNP (NCT02740179)
Timeframe: 12 Months

Intervention	ng/L (Median)
Eplerenone	19.4
Placebo	2.8

Markers of Systemic Inflammation hsCRP

Change (value at 12 months minus value at baseline) in plasma hsCRP (NCT02740179)
Timeframe: 12 Months

Intervention	ng/mL (Median)
Eplerenone	189
Placebo	591

Markers of Systemic Inflammation hsIL-6

Change (value at 12 months minus value at baseline) in plasma hsIL-6 (NCT02740179)
Timeframe: 12 Months

Intervention	pg/mL (Median)
Eplerenone	-0.8
Placebo	0.2

Markers of Vascular Dysfunction

Change (value at 12 months minus value at baseline) in serum hs-cTnT (NCT02740179)
Timeframe: 12 Months

Intervention	ng/L (Median)
Eplerenone	0.00
Placebo	0.00

Myocardial Inflammation

Change (value at 12 months minus value at baseline) in myocardial inflammation measured by extracellular mass index (a measure of the inflammation within the heart) via cardiac magnetic resonance imaging (NCT02740179)
Timeframe: 12 Months

Intervention	g/m^2 (Median)
Eplerenone	0.9
Placebo	-0.7

Myocardial Perfusion by MRI

Change (value at 12 months minus value at baseline) in myocardial perfusion assessed by myocardial blood flow measured via cardiac magnetic resonance imaging (NCT02740179)
Timeframe: 12 Months

Intervention	mL/min/g (Mean)
Eplerenone	0.09
Placebo	-0.53

Myocardial Perfusion by PET

Change (value at 12 months minus value at baseline) in myocardial perfusion assessed by coronary flow reserve measured via cardiac positron emission tomography. Coronary flow reserve is given by the ratio of blood flow at stress during maximal dilation of the coronary arteries to blood flow at rest. (NCT02740179)
Timeframe: 12 Months

Intervention	unitless (Mean)
Eplerenone	0.01
Placebo	-0.07

Reviews

2 reviews available for aldosterone and HIV Coinfection

Article	Year
Coronary Vasculature and Myocardial Structure in HIV: Physiologic Insights From the Renin-Angiotensin-Aldosterone System. The Journal of clinical endocrinology and metabolism, 2021, 11-19, Volume: 106, Issue:12 Topics: Aldosterone; Cardiovascular Diseases; Coronary Artery Disease; HIV; HIV Infections; Humans; Myocardi	2021
Adrenal function in HIV infection. Current opinion in endocrinology, diabetes, and obesity, 2010, Volume: 17, Issue:3 Topics: Adrenal Glands; Aldosterone; Glucocorticoids; HIV Infections; Humans; Hydrocortisone; Mineralocortic	2010

Trials

1 trial available for aldosterone and HIV Coinfection

Article	Year
RAAS Activation Is Associated With Visceral Adiposity and Insulin Resistance Among HIV-infected Patients. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:8 Topics: Adiposity; Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Female; HI	2015
RAAS Activation Is Associated With Visceral Adiposity and Insulin Resistance Among HIV-infected Patients. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:8 Topics: Adiposity; Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Female; HI	2015
RAAS Activation Is Associated With Visceral Adiposity and Insulin Resistance Among HIV-infected Patients. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:8 Topics: Adiposity; Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Female; HI	2015
RAAS Activation Is Associated With Visceral Adiposity and Insulin Resistance Among HIV-infected Patients. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:8 Topics: Adiposity; Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Female; HI	2015
RAAS Activation Is Associated With Visceral Adiposity and Insulin Resistance Among HIV-infected Patients. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:8 Topics: Adiposity; Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Female; HI	2015
RAAS Activation Is Associated With Visceral Adiposity and Insulin Resistance Among HIV-infected Patients. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:8 Topics: Adiposity; Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Female; HI	2015
RAAS Activation Is Associated With Visceral Adiposity and Insulin Resistance Among HIV-infected Patients. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:8 Topics: Adiposity; Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Female; HI	2015
RAAS Activation Is Associated With Visceral Adiposity and Insulin Resistance Among HIV-infected Patients. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:8 Topics: Adiposity; Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Female; HI	2015
RAAS Activation Is Associated With Visceral Adiposity and Insulin Resistance Among HIV-infected Patients. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:8 Topics: Adiposity; Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Female; HI	2015

Other Studies

8 other studies available for aldosterone and HIV Coinfection

Article	Year
Role of renin-angiotensin-aldosterone system activation and other metabolic variables in relation to arterial inflammation in HIV. Clinical endocrinology, 2022, Volume: 97, Issue:5 Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Aldosterone; Arteritis; HIV Infections; Humans; Reni	2022
Correlation of baseline hormonal disorders with immunological failure and mortality in male HIV patients during follow-up. Medicine, 2016, Volume: 95, Issue:52 Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Anti-HIV Agents; CD4 Lymphocyte Count; Dehydroepian	2016
Increased aldosterone among HIV-infected women with visceral fat accumulation. AIDS (London, England), 2009, Nov-13, Volume: 23, Issue:17 Topics: Adult; Aldosterone; Biomarkers; Body Mass Index; Case-Control Studies; Female; HIV Infections; Human	2009
Haemodynamic derangement in human immunodeficiency virus-infected patients with hepatitis C virus-related cirrhosis: the role of bacterial translocation. Liver international : official journal of the International Association for the Study of the Liver, 2011, Volume: 31, Issue:6 Topics: Acute-Phase Proteins; Adult; Aged; Aldosterone; Analysis of Variance; Bacterial Translocation; Carri	2011
Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus. Steroids, 2007, Volume: 72, Issue:4 Topics: Adrenal Cortex; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aldosterone; alpha-Amylas	2007
Endocrine testicular function in HIV-infected outpatients. European journal of medical research, 1997, Jul-28, Volume: 2, Issue:7 Topics: Adult; Aldosterone; Analysis of Variance; CD4 Lymphocyte Count; Chi-Square Distribution; Dehydroepia	1997
Hyperkalemia in patients infected with the human immunodeficiency virus: involvement of a systemic mechanism. Kidney international, 1999, Volume: 56, Issue:1 Topics: Adult; Aldosterone; Arginine; Female; HIV Infections; Humans; Hyperkalemia; Injections, Intravenous;	1999
Steroid response to adrenocorticotropin stimulation in children with human immunodeficiency virus infection. The Journal of clinical endocrinology and metabolism, 1990, Volume: 70, Issue:3 Topics: Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Aldosterone; Child; Child, Preschool; Co	1990