aldosterone has been researched along with Glomerulosclerosis, Focal Segmental in 12 studies
Glomerulosclerosis, Focal Segmental: A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aldosterone has pro-fibrotic properties and is a potential target for additional intervention in patients with chronic renal disease showing resistance to therapy during treatment with angiotensin-converting enzyme inhibitors (ACEi)." | 5.34 | Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis. ( Hamming, I; Kramer, AB; Navis, G; van der Meulen, EF; van Goor, H, 2007) |
| "Treatment with rotenone, an inhibitor of mitochondrial complex I, significantly attenuated oxidative stress, mitochondrial dysfunction, and inflammasome response in aldosterone-infused rats." | 1.42 | Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation. ( Ding, W; Wang, B; Xu, C; Zhang, M, 2015) |
| "Aldosterone has pro-fibrotic properties and is a potential target for additional intervention in patients with chronic renal disease showing resistance to therapy during treatment with angiotensin-converting enzyme inhibitors (ACEi)." | 1.34 | Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis. ( Hamming, I; Kramer, AB; Navis, G; van der Meulen, EF; van Goor, H, 2007) |
| "Aldosterone promotes nephrosclerosis in several rat models, whereas aldosterone receptor antagonism blunts the effect of activation of the renin-angiotensin-aldosterone system (RAAS) on nephrosclerosis, independent of effects on blood pressure." | 1.31 | Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. ( Brown, NJ; Donnert, E; Fogo, AB; Freeman, M; Ma, L; Nakamura, I; Nakamura, S; Vaughan, DE, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, W | 1 |
| Xu, C | 1 |
| Wang, B | 1 |
| Zhang, M | 1 |
| Manger, WM | 1 |
| Simchon, S | 1 |
| Stokes, MB | 1 |
| Reidy, JJ | 1 |
| Kumar, AR | 1 |
| Baer, L | 1 |
| Gallo, G | 1 |
| Haddy, FJ | 1 |
| Lahmer, T | 1 |
| Hermans, R | 1 |
| Schmaderer, C | 1 |
| Chang, J | 1 |
| Stock, K | 1 |
| Lutz, J | 1 |
| Heemann, U | 1 |
| Baumann, M | 1 |
| Kramer, AB | 1 |
| van der Meulen, EF | 1 |
| Hamming, I | 1 |
| van Goor, H | 1 |
| Navis, G | 1 |
| Peters, B | 1 |
| Grisk, O | 1 |
| Becher, B | 1 |
| Wanka, H | 1 |
| Kuttler, B | 1 |
| Lüdemann, J | 1 |
| Lorenz, G | 1 |
| Rettig, R | 1 |
| Mullins, JJ | 1 |
| Peters, J | 1 |
| Stoian, M | 1 |
| Radulian, G | 1 |
| Chiţac, D | 1 |
| Simion, E | 1 |
| Stoica, V | 1 |
| Geers, AB | 1 |
| Koomans, HA | 1 |
| Roos, JC | 1 |
| Boer, P | 1 |
| Dorhout Mees, EJ | 1 |
| Stalnikowicz, R | 1 |
| Shalev, O | 1 |
| Rosenmann, E | 1 |
| Ben-Ishay, D | 1 |
| Brown, NJ | 1 |
| Nakamura, S | 1 |
| Ma, L | 2 |
| Nakamura, I | 1 |
| Donnert, E | 1 |
| Freeman, M | 1 |
| Vaughan, DE | 1 |
| Fogo, AB | 2 |
| Swainson, CP | 1 |
| Nicholls, MG | 1 |
| Espiner, EA | 1 |
| Nakamoto, Y | 1 |
| Imai, H | 1 |
| Hamanaka, S | 1 |
| Yoshida, K | 1 |
| Akihama, T | 1 |
| Miura, AB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Crossover Pilot Study of the Effect of Amiloride on Proteinuria in Patients With Proteinuric Kidney Disease[NCT02522650] | Phase 4 | 30 participants (Anticipated) | Interventional | 2013-07-31 | Recruiting | ||
| [NCT00005757] | 293 participants (Actual) | Observational | 1997-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for aldosterone and Glomerulosclerosis, Focal Segmental
| Article | Year |
|---|---|
A clinical approach in regression of glomerulosclerosis.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme | 2007 |
Role of angiotensin II in glomerular injury.
Topics: Aldosterone; Angiotensin II; Animals; Glomerulosclerosis, Focal Segmental; Humans; Kidney Glomerulus | 2001 |
10 other studies available for aldosterone and Glomerulosclerosis, Focal Segmental
| Article | Year |
|---|---|
Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation.
Topics: Adenosine Triphosphate; Aldosterone; Animals; Carrier Proteins; DNA, Mitochondrial; Glomeruloscleros | 2015 |
Renal functional, not morphological, abnormalities account for salt sensitivity in Dahl rats.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Cyclic GMP; Diastole; Dose-Response Relationsh | 2009 |
Mineralocorticoid receptor antagonism and aldosterone synthesis inhibition do not improve glomerulosclerosis and renal interstitial fibrosis in a model of chronic kidney allograft injury.
Topics: Aldosterone; Animals; Disease Models, Animal; Extracellular Fluid; Fibrosis; Glomerulosclerosis, Foc | 2012 |
Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis.
Topics: Actins; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Biomarkers; Blood Pressure; | 2007 |
Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis.
Topics: Administration, Oral; Aldosterone; Animals; Animals, Genetically Modified; Blood Pressure; Cytochrom | 2008 |
Functional relationships in the nephrotic syndrome.
Topics: Adolescent; Adult; Aged; Aldosterone; Blood Pressure; Blood Volume; Creatinine; Diet, Sodium-Restric | 1984 |
Hyporeninemic hypoaldosteronism associated with focal glomerular sclerosis in a patient with chronic lymphocytic leukemia.
Topics: Aged; Aldosterone; Fludrocortisone; Furosemide; Glomerulonephritis; Glomerulosclerosis, Focal Segmen | 1982 |
Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Blotting, Northern; Creatinine; Disease Progre | 2000 |
No evidence of failure of the renin-angiotensin system in focal glomerulosclerosis in man.
Topics: Aldosterone; Blood Pressure; Female; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Humans | 1986 |
IgM monoclonal gammopathy accompanied by nodular glomerulosclerosis, urine-concentrating defect, and hyporeninemic hypoaldosteronism.
Topics: Aldosterone; Biopsy; Cyclophosphamide; Drug Therapy, Combination; Fluorescent Antibody Technique; Gl | 1985 |