Page last updated: 2024-11-07

aldosterone and Genetic Predisposition

aldosterone has been researched along with Genetic Predisposition in 65 studies

Research Excerpts

ExcerptRelevanceReference
"Functional changes in the kidneys of healthy men with (FH+) (n = 15) and without (FH-) (n = 15) family history of primary arterial hypertension were examined during administration of low-dose exogenous angiotensin II (A2) (1 ng/kg per min) before and after acute (1 mg intravenous enalaprilat) and chronic (7 days oral enalapril, 30 mg/day) angiotensin-converting enzyme (ACE) inhibition."7.72Increased renovascular response to angiotensin II in persons genetically predisposed to arterial hypertension disappears after chronic angiotensin-converting enzyme inhibition. ( Bock, A; Dieterle, T; Drewe, J; Gyr, K; Haberthür, C; Huber, PR; Martina, B; Schächinger, H, 2004)
"Smoking and dyslipidemia are more potent risk factors for nonfatal MI in males who have the -344C allele of CYP11B2."6.69Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction. ( Hautanen, A; Kayes, KM; Kupari, M; Manninen, V; Mänttäri, M; Rosenfeld, S; Tenkanen, L; Toivanen, P; White, PC, 1999)
"In the setting of primary aldosteronism, elevated aldosterone levels are associated with increased blood pressure."6.46Aldosterone and arterial hypertension. ( Obermayer-Pietsch, B; Pieber, TR; Pilz, S; Ritz, E; Tomaschitz, A, 2010)
"Aldosterone treatment increased lipid content of plaques (2."5.39Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism. ( Armani, A; Bagley, J; Caprio, M; Carmeliet, P; Chen, WS; Galayda, C; Jaffe, IZ; McGraw, AP; Nickerson, H, 2013)
"1."5.37Association of the aldosterone synthase gene -344T>C polymorphism with essential hypertension and glucose homeostasis: a case-control study in a Han Chinese population. ( Chen, HY; Gao, X; Li, XM; Ling, Y; Liu, Y; Lu, DR; Lu, ZQ; Yi, QL, 2011)
"The aldosterone level was comparable in both groups."5.35Diastolic dysfunction is associated with insulin resistance, but not with aldosterone level in normotensive offspring of hypertensive families. ( Poredos, P; Trojar, A; Zeljko, T; Zizek, B, 2008)
"Essential hypertension is a disease multifactorially triggered by genetic and environmental factors."5.34Analysis of renin-angiotensin-aldosterone system gene polymorphisms in resistant hypertension. ( Barros, M; Bittencourt, I; Cabello, PH; Cordovil, IL; Dolinsky, LC; Freitas, SR; Lima, AB; Moura-Neto, RS, 2007)
"Aldosterone is a risk factor for stroke, and the literature suggests it may play a role in increasing the expression of the receptor for EGF (EGFR)."5.31Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats. ( Dorrance, AM; Grekin, R; Osborn, HL; Webb, RC, 2001)
"Functional changes in the kidneys of healthy men with (FH+) (n = 15) and without (FH-) (n = 15) family history of primary arterial hypertension were examined during administration of low-dose exogenous angiotensin II (A2) (1 ng/kg per min) before and after acute (1 mg intravenous enalaprilat) and chronic (7 days oral enalapril, 30 mg/day) angiotensin-converting enzyme (ACE) inhibition."3.72Increased renovascular response to angiotensin II in persons genetically predisposed to arterial hypertension disappears after chronic angiotensin-converting enzyme inhibition. ( Bock, A; Dieterle, T; Drewe, J; Gyr, K; Haberthür, C; Huber, PR; Martina, B; Schächinger, H, 2004)
"Elevations in plasma aldosterone enhance stroke development within captopril-treated SHRSP through mechanisms that do not involve stimulation of mineralocorticoid receptors or the enhancement of hypertension."3.69The role of blood pressure and aldosterone in the production of hemorrhagic stroke in captopril-treated hypertensive rats. ( MacLeod, AB; Smeda, JS; Vasdev, S, 1997)
"Smoking and dyslipidemia are more potent risk factors for nonfatal MI in males who have the -344C allele of CYP11B2."2.69Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction. ( Hautanen, A; Kayes, KM; Kupari, M; Manninen, V; Mänttäri, M; Rosenfeld, S; Tenkanen, L; Toivanen, P; White, PC, 1999)
"Primary aldosteronism (PA) is the most common form of secondary hypertension affecting 5%-10% of patients with arterial hypertension."2.66Old and new genes in primary aldosteronism. ( Boulkroun, S; Fernandes-Rosa, FL; Zennaro, MC, 2020)
"Pseudohyperaldosteronism is characterized by a clinical picture of hyperaldosteronism with suppression of renin and aldosterone."2.53Syndromes that Mimic an Excess of Mineralocorticoids. ( Armanini, D; Sabbadin, C, 2016)
"Primary aldosteronism is the most common form of secondary hypertension and affects 8-13% of patients with hypertension."2.53Genetics of primary hyperaldosteronism. ( Dutta, RK; Gimm, O; Söderkvist, P, 2016)
"In the setting of primary aldosteronism, elevated aldosterone levels are associated with increased blood pressure."2.46Aldosterone and arterial hypertension. ( Obermayer-Pietsch, B; Pieber, TR; Pilz, S; Ritz, E; Tomaschitz, A, 2010)
"Human hypertension affects affects more than 20% of the adult population in industrialized countries, and it is implicated in millions of deaths worldwide each year from stroke, heart failure and ischemic heart disease."2.44Genetics of arterial hypertension and hypotension. ( Rimmbach, C; Rosskopf, D; Schäfers, R; Schürks, M, 2007)
"APA cause primary aldosteronism (PA), which affect 3-10% of the hypertensive population."1.51Aldosterone-Producing Adenomas. ( Åkerström, T; Björklund, P; Hellman, P, 2019)
"The adrenal glands with adrenocortical adenomas from 79 black patients with primary aldosteronism were studied."1.51Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks. ( Barletta, JA; Cohen, DL; Demidowich, AP; Else, T; Gellert, L; Giordano, TJ; Gomez-Sanchez, CE; Luther, JM; Nanba, K; Omata, K; Rainey, WE; Stratakis, CA; Suzuki, M; Thompson, LDR; Tomlins, SA; Vaidya, A, 2019)
"Aldosterone values were significantly higher in animals carrying mutations in four different genes (Sspo, Dguok, Hoxaas2 and Clstn3) and associated statistically significant adrenal Cyp11b2 overexpression as well as increased ARR was present only in mice with Sspo mutation."1.46Genetic characterization of a mouse line with primary aldosteronism. ( Beuschlein, F; Hantel, C; Hrabě de Angelis, M; Perez-Rivas, LG; Rathkolb, B; Reincke, M; Rhayem, Y; Sabrautzki, S; Spyroglou, A, 2017)
"Primary aldosteronism is the most common form of secondary hypertension."1.40Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma. ( Allolio, B; Amar, L; Bernini, G; Beuschlein, F; Boulkroun, S; Cicala, MV; Fallo, F; Fernandes-Rosa, FL; Giacchetti, G; Jeunemaitre, X; Maccario, M; Mantero, F; Meatchi, T; Monticone, S; Mulatero, P; Quinkler, M; Reincke, M; Riester, A; Steichen, O; Strom, TM; Williams, TA; Zennaro, MC, 2014)
"Aldosterone treatment increased lipid content of plaques (2."1.39Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism. ( Armani, A; Bagley, J; Caprio, M; Carmeliet, P; Chen, WS; Galayda, C; Jaffe, IZ; McGraw, AP; Nickerson, H, 2013)
"Primary hyperaldosteronism, one cause of which is aldosterone-producing adenomas (APAs), may account for ≤5% to 10% of cases of essential hypertension."1.38Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas. ( Azizan, EA; Brown, MJ; Gordon, R; Kowalski, B; Murthy, M; O'Shaughnessy, KM; Stowasser, M; Xu, S, 2012)
"1."1.37Association of the aldosterone synthase gene -344T>C polymorphism with essential hypertension and glucose homeostasis: a case-control study in a Han Chinese population. ( Chen, HY; Gao, X; Li, XM; Ling, Y; Liu, Y; Lu, DR; Lu, ZQ; Yi, QL, 2011)
"Metabolic syndrome was defined according to ATPIII criteria."1.36Metabolic syndrome in primary aldosteronism and essential hypertension: relationship to adiponectin gene variants. ( Agostinelli, L; Boscaro, M; Di Mattia, D; Giacchetti, G; Rilli, S; Ronconi, V; Turchi, F, 2010)
"The aldosterone level was comparable in both groups."1.35Diastolic dysfunction is associated with insulin resistance, but not with aldosterone level in normotensive offspring of hypertensive families. ( Poredos, P; Trojar, A; Zeljko, T; Zizek, B, 2008)
"Essential hypertension is a disease multifactorially triggered by genetic and environmental factors."1.34Analysis of renin-angiotensin-aldosterone system gene polymorphisms in resistant hypertension. ( Barros, M; Bittencourt, I; Cabello, PH; Cordovil, IL; Dolinsky, LC; Freitas, SR; Lima, AB; Moura-Neto, RS, 2007)
"Aldosterone is a risk factor for stroke, and the literature suggests it may play a role in increasing the expression of the receptor for EGF (EGFR)."1.31Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats. ( Dorrance, AM; Grekin, R; Osborn, HL; Webb, RC, 2001)

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (4.62)18.2507
2000's25 (38.46)29.6817
2010's33 (50.77)24.3611
2020's4 (6.15)2.80

Authors

AuthorsStudies
Boulkroun, S2
Fernandes-Rosa, FL2
Zennaro, MC2
Sydorchuk, L1
Dzhuryak, V1
Sydorchuk, A1
Levytska, S1
Petrynych, V1
Knut, R1
Kshanovska, A1
Iftoda, O1
Tkachuk, O1
Kyfiak, P1
Popovich, A1
Khomko, O1
Sydorchuk, R1
Stone, IB1
Green, JAEM1
Koefoed, AW1
Hornik, ES1
Williams, JS1
Adler, GK2
Williams, GH3
Dutta, RK2
Larsson, M1
Arnesen, T1
Heie, A1
Walz, M1
Alesina, P1
Gimm, O2
Söderkvist, P2
Armanini, D2
Andrisani, A1
Donà, G1
Bordin, L1
Ambrosini, G1
Sabbadin, C2
Zheng, FF1
Zhu, LM1
Zhou, WL1
Zhang, Y1
Li, MY1
Zhu, YC1
Wang, JG1
Zhu, DL1
Gao, PJ1
Scholl, UI1
Hellman, P1
Björklund, P1
Åkerström, T1
Nanba, K1
Omata, K1
Gomez-Sanchez, CE2
Stratakis, CA1
Demidowich, AP1
Suzuki, M1
Thompson, LDR1
Cohen, DL1
Luther, JM1
Gellert, L1
Vaidya, A1
Barletta, JA1
Else, T1
Giordano, TJ1
Tomlins, SA1
Rainey, WE1
Funder, JW2
McGraw, AP1
Bagley, J1
Chen, WS1
Galayda, C1
Nickerson, H1
Armani, A1
Caprio, M1
Carmeliet, P1
Jaffe, IZ1
Shlipak, MG1
Day, EC1
Orenes-Piñero, E1
Hernández-Romero, D1
Romero-Aniorte, AI1
Martínez, M1
García-Honrubia, A1
Caballero, L1
Garrigos-Gómez, N1
Andreu-Cayuelas, JM1
González, J1
Feliu, E1
Climent, V1
Nicolás-Ruiz, F1
De La Morena, G1
Valdés, M1
Lip, GY1
Marín, F1
Fischer, E1
Beuschlein, F3
Williams, TA1
Riester, A1
Steichen, O1
Strom, TM1
Monticone, S1
Amar, L1
Meatchi, T1
Mantero, F1
Cicala, MV1
Quinkler, M1
Fallo, F1
Allolio, B1
Bernini, G1
Maccario, M1
Giacchetti, G2
Jeunemaitre, X3
Mulatero, P1
Reincke, M2
Verwoert, GC1
Hofland, J1
Amin, N1
Mattace-Raso, FU1
Sijbrands, EJ1
Hofman, A1
van den Meiracker, AH1
Uitterlinden, AG1
van Duijn, CM1
de Jong, FH1
Danser, AH1
Richards, J1
Diaz, AN1
Gumz, ML1
Johnson, AK1
Zhang, Z1
Clayton, SC1
Beltz, TG1
Hurley, SW1
Thunhorst, RL1
Xue, B1
Manichaikul, A1
Rich, SS1
Allison, MA1
Guagliardo, NA1
Bayliss, DA1
Carey, RM2
Barrett, PQ1
Perez-Rivas, LG1
Rhayem, Y1
Sabrautzki, S1
Hantel, C1
Rathkolb, B1
Hrabě de Angelis, M1
Spyroglou, A1
Jones, ES1
Spence, JD1
Mcintyre, AD1
Nondi, J1
Gogo, K1
Akintunde, A1
Hackam, DG1
Rayner, BL2
MacKenzie, SM2
Freel, EM1
Connell, JM2
Fraser, R3
Davies, E2
Escher, G1
Cristiano, M1
Causevic, M1
Baumann, M1
Frey, FJ1
Surbek, D1
Mohaupt, MG1
Kidambi, S1
Kotchen, JM1
Krishnaswami, S1
Grim, CE2
Kotchen, TA1
Ronconi, V1
Turchi, F1
Rilli, S1
Di Mattia, D1
Agostinelli, L1
Boscaro, M1
Nejatizadeh, A2
Kumar, R3
Stobdan, T1
Goyal, AK1
Gupta, M2
Tyagi, S2
Jain, SK2
Pasha, MA2
Tomaschitz, A1
Pilz, S1
Ritz, E1
Obermayer-Pietsch, B1
Pieber, TR1
Gomez-Sanchez, EP1
Cheng, X1
Xu, G1
Wang, B1
Zhang, G1
Ouyang, J1
Deng, X1
Shi, T1
Ma, X1
Li, H1
Ju, Z1
Wang, C1
Wu, Z1
Liu, S1
Zhang, X1
Somekh, NN1
Finkielstein, D1
Hiura, Y1
Tabara, Y1
Kokubo, Y1
Okamura, T1
Miki, T1
Tomoike, H1
Iwai, N1
Brown, MB1
Haack, KK1
Pollack, BP1
Millard-Stafford, M1
McCarty, NA1
Li, XM1
Ling, Y1
Lu, DR1
Lu, ZQ1
Yi, QL1
Liu, Y1
Chen, HY1
Gao, X1
Markan, A1
Azizan, EA1
Murthy, M1
Stowasser, M1
Gordon, R1
Kowalski, B1
Xu, S1
Brown, MJ1
O'Shaughnessy, KM1
Schoeffel, CD1
Gildea, JJ1
Jones, JE1
McGrath, HE1
Gordon, LN1
Park, MJ1
Sobota, RS1
Underwood, PC1
Williams, J1
Sun, B1
Raby, B1
Lasky-Su, J1
Hopkins, PN2
Williams, SM1
Jose, PA1
Felder, RA1
Pratt, JH2
Ambrosius, WT2
Agarwal, R1
Eckert, GJ1
Newman, S1
Persu, A1
Owen, EP1
King, JA1
Soule, SG1
Vreede, H1
Opie, LH1
Marais, D1
Davidson, JS1
Qadar Pasha, MA1
Khan, AP1
Gupta, V1
Grover, SK1
Norboo, T1
Srivastava, KK1
Selvamurthy, W1
Brahamchari, SK1
Okano, H1
Ohkubo, C1
Kosachunhanun, N1
Hunt, SC1
Williams, RR1
Corvol, P2
Ferri, C1
Mortensen, RM1
Hollenberg, NK1
El-Atat, F1
Aneja, A1
Mcfarlane, S1
Sowers, J1
Schächinger, H1
Dieterle, T1
Martina, B1
Haberthür, C1
Huber, PR1
Bock, A1
Drewe, J1
Gyr, K1
Friel, EC1
Ingram, MC1
Holloway, CD1
Kamide, K1
Tanaka, C1
Takiuchi, S1
Miwa, Y1
Yoshii, M1
Horio, T1
Kawano, Y1
Miyata, T1
Hannila-Handelberg, T1
Kontula, K1
Tikkanen, I1
Tikkanen, T1
Fyhrquist, F1
Helin, K1
Fodstad, H1
Piippo, K1
Miettinen, HE1
Virtamo, J1
Krusius, T1
Sarna, S1
Gautschi, I1
Schild, L1
Hiltunen, TP1
Achard, JM1
Hadchouel, J1
Faure, S1
Sookoian, S1
Gianotti, TF1
González, CD1
Pirola, CJ1
Rosskopf, D1
Schürks, M1
Rimmbach, C1
Schäfers, R1
Freitas, SR1
Cabello, PH1
Moura-Neto, RS1
Dolinsky, LC1
Lima, AB1
Barros, M1
Bittencourt, I1
Cordovil, IL1
Zizek, B1
Poredos, P1
Trojar, A1
Zeljko, T1
Harrap, SB1
Davidson, HR1
Connor, JM1
Soubrier, F1
Foy, CJ1
Watt, GC1
MacLeod, AB1
Vasdev, S1
Smeda, JS1
Hautanen, A1
Toivanen, P1
Mänttäri, M1
Tenkanen, L1
Kupari, M1
Manninen, V1
Kayes, KM1
Rosenfeld, S1
White, PC1
Wagner, MA1
Maharry, K1
Poch, E1
González, D1
de la Sierra, A1
Giner, V1
Bragulat, E1
Botey, A1
Coca, A1
Rivera, F1
Takeda, Y1
Yoneda, T1
Demura, M1
Furukawa, K1
Miyamori, I1
Mabuchi, H1
Dorrance, AM1
Osborn, HL1
Grekin, R1
Webb, RC1
Campese, VM1
Lasseter, KC1
Ferrario, CM1
Smith, WB1
Ruddy, MC1
Smith, RD1
Vargas, R1
Habashy, MF1
Vesterqvist, O1
Delaney, CL1
Liao, WC1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension[NCT05593055]Phase 475 participants (Anticipated)Interventional2023-08-25Recruiting
Salt Sensitive Hypertension and Striatin[NCT03683069]Phase 4400 participants (Actual)Interventional2019-01-15Active, not recruiting
[NCT00005181]0 participants Observational2000-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

18 reviews available for aldosterone and Genetic Predisposition

ArticleYear
Old and new genes in primary aldosteronism.
    Best practice & research. Clinical endocrinology & metabolism, 2020, Volume: 34, Issue:2

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Aldosterone; Genetic Association Studies; Genetic

2020
Unanswered Questions in the Genetic Basis of Primary Aldosteronism.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2017, Volume: 49, Issue:12

    Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenal Glands; Adrenocortical Adenoma; Aldosterone; DNA Copy Num

2017
Primary Aldosteronism.
    Hypertension (Dallas, Tex. : 1979), 2019, Volume: 74, Issue:3

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Aldosterone; beta Catenin; Calcium Channels, L-Typ

2019
Biomarkers for incident CKD: a new framework for interpreting the literature.
    Nature reviews. Nephrology, 2013, Volume: 9, Issue:8

    Topics: Acute-Phase Proteins; Aldosterone; Biomarkers; Connective Tissue Growth Factor; Creatinine; Cystatin

2013
Novel genes in primary aldosteronism.
    Current opinion in endocrinology, diabetes, and obesity, 2014, Volume: 21, Issue:3

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Aldosterone; Calcium Channels, L-Type; Female; G P

2014
Expression and gene variation studies deny association of human HSD3B1 gene with aldosterone production or blood pressure.
    American journal of hypertension, 2015, Volume: 28, Issue:1

    Topics: Adrenal Cortex; Aged; Aldosterone; Blood Pressure; Cells, Cultured; Female; Gene Expression Regulati

2015
Clock genes in hypertension: novel insights from rodent models.
    Blood pressure monitoring, 2014, Volume: 19, Issue:5

    Topics: Aldosterone; Animals; ARNTL Transcription Factors; Blood Vessels; Circadian Rhythm; CLOCK Proteins;

2014
The roles of sensitization and neuroplasticity in the long-term regulation of blood pressure and hypertension.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2015, Dec-01, Volume: 309, Issue:11

    Topics: Adaptation, Physiological; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiovascular Syst

2015
Syndromes that Mimic an Excess of Mineralocorticoids.
    High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2016, Volume: 23, Issue:3

    Topics: Aldosterone; Biomarkers; Cushing Syndrome; Dexamethasone; Diet; Genetic Predisposition to Disease; G

2016
Genetics of primary hyperaldosteronism.
    Endocrine-related cancer, 2016, Volume: 23, Issue:10

    Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Adrenocortical Adenoma; Aldosterone; Animals; Genetic Pred

2016
ACTH and Polymorphisms at Steroidogenic Loci as Determinants of Aldosterone Secretion and Blood Pressure.
    International journal of molecular sciences, 2017, Mar-07, Volume: 18, Issue:3

    Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Blood Pressure; Cytochrome P-450 CYP11B2; Genetic

2017
Aldosterone and arterial hypertension.
    Nature reviews. Endocrinology, 2010, Volume: 6, Issue:2

    Topics: Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Blood Vessels; Brain; Cytochrome P-45

2010
A systemic review of the relationship between aldosterone synthase - 344 C/T polymorphism and hypertension in Han.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2010, Volume: 32, Issue:5

    Topics: Aldosterone; China; Female; Genetic Predisposition to Disease; Humans; Hypertension; Male; Polymorph

2010
Obesity and hypertension.
    Endocrinology and metabolism clinics of North America, 2003, Volume: 32, Issue:4

    Topics: Adipose Tissue; Aldosterone; Body Mass Index; Cardiovascular System; Genetic Predisposition to Disea

2003
The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation.
    Molecular and cellular endocrinology, 2004, Mar-31, Volume: 217, Issue:1-2

    Topics: Adrenocorticotropic Hormone; Aldosterone; Blood Pressure; Cortodoxone; Cytochrome P-450 CYP11B2; Gen

2004
Inherited sodium avid states.
    Advances in chronic kidney disease, 2006, Volume: 13, Issue:2

    Topics: Aldosterone; Genetic Predisposition to Disease; Humans; Hypertension; Nephrons; Renin; Sodium; Sodiu

2006
Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis.
    Journal of hypertension, 2007, Volume: 25, Issue:1

    Topics: Aldosterone; Blood Pressure; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Cytochro

2007
Genetics of arterial hypertension and hypotension.
    Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 374, Issue:5-6

    Topics: Aldosterone; Blood Pressure; Genetic Predisposition to Disease; Humans; Hydrocortisone; Hypertension

2007

Trials

6 trials available for aldosterone and Genetic Predisposition

ArticleYear
Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design.
    Pharmacogenetics and genomics, 2021, 06-01, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Aged; Aldosterone; Alleles; Amlodipine; Animals; Blood Pressure; Calmodulin-Bindi

2021
Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design.
    Pharmacogenetics and genomics, 2021, 06-01, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Aged; Aldosterone; Alleles; Amlodipine; Animals; Blood Pressure; Calmodulin-Bindi

2021
Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design.
    Pharmacogenetics and genomics, 2021, 06-01, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Aged; Aldosterone; Alleles; Amlodipine; Animals; Blood Pressure; Calmodulin-Bindi

2021
Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design.
    Pharmacogenetics and genomics, 2021, 06-01, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Aged; Aldosterone; Alleles; Amlodipine; Animals; Blood Pressure; Calmodulin-Bindi

2021
Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:5

    Topics: Adult; Aldosterone; Blood Pressure; Body Mass Index; Diet; Dose-Response Relationship, Drug; Female;

2012
Racial difference in the activity of the amiloride-sensitive epithelial sodium channel.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:6

    Topics: Adolescent; Adult; Aldosterone; Amiloride; Black People; Blood Pressure; Body Mass Index; Cohort Stu

2002
Genetic factors associated with volume-sensitive hypertension.
    Molecular and cellular endocrinology, 2004, Mar-31, Volume: 217, Issue:1-2

    Topics: Age Factors; Aldosterone; Angiotensin II; Angiotensinogen; Blood Volume; Calmodulin-Binding Proteins

2004
Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction.
    Circulation, 1999, Nov-30, Volume: 100, Issue:22

    Topics: Adult; Aldosterone; Alleles; Baroreflex; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; C

1999
Omapatrilat versus lisinopril: efficacy and neurohormonal profile in salt-sensitive hypertensive patients.
    Hypertension (Dallas, Tex. : 1979), 2001, Dec-01, Volume: 38, Issue:6

    Topics: Adult; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood

2001

Other Studies

41 other studies available for aldosterone and Genetic Predisposition

ArticleYear
The cytochrome 11B2 aldosterone synthase gene rs1799998 single nucleotide polymorphism determines elevated aldosterone, higher blood pressure, and reduced glomerular filtration, especially in diabetic female patients.
    Endocrine regulations, 2020, Jul-01, Volume: 54, Issue:3

    Topics: Adult; Aged; Aldosterone; Blood Pressure; Case-Control Studies; Cytochrome P-450 CYP11B2; Diabetes M

2020
X-chromosome variants are associated with aldosterone producing adenomas.
    Scientific reports, 2021, 05-18, Volume: 11, Issue:1

    Topics: Adenoma; Aldosterone; Carrier Proteins; Case-Control Studies; Chromosomes, Human, X; Cohort Studies;

2021
Hypothesis on a relationship between hyperaldosteronism, inflammation, somatic mutations, and autoimmunity.
    Journal of clinical hypertension (Greenwich, Conn.), 2017, Volume: 19, Issue:11

    Topics: Aldosterone; Autoimmunity; Desoxycorticosterone; Genetic Predisposition to Disease; Humans; Hyperald

2017
A novel somatic mutation 145-147delETEinsK in KCNJ5 increases aldosterone production.
    Journal of human hypertension, 2017, Volume: 31, Issue:11

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Aldosterone; Biomarkers, Tumor; Calcium; Female; G

2017
Aldosterone-Producing Adenomas.
    Vitamins and hormones, 2019, Volume: 109

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Aldosterone; Genetic Predisposition to Disease; Hu

2019
Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks.
    Hypertension (Dallas, Tex. : 1979), 2019, Volume: 73, Issue:4

    Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Adrenocortical Adenoma; Aldosterone; Black or African Amer

2019
Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism.
    Journal of the American Heart Association, 2013, Feb-22, Volume: 2, Issue:1

    Topics: Aldosterone; Animals; Aorta, Abdominal; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Chemoki

2013
Prognostic value of two polymorphisms in non-sarcomeric genes for the development of atrial fibrillation in patients with hypertrophic cardiomyopathy.
    QJM : monthly journal of the Association of Physicians, 2014, Volume: 107, Issue:8

    Topics: Adult; Aged; Aldosterone; Atrial Fibrillation; Cardiomyopathy, Hypertrophic; Case-Control Studies; C

2014
Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma.
    Hypertension (Dallas, Tex. : 1979), 2014, Volume: 64, Issue:2

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Adult; Age Factors; Aldosterone; Calcium Channels,

2014
KCNK3 Variants Are Associated With Hyperaldosteronism and Hypertension.
    Hypertension (Dallas, Tex. : 1979), 2016, Volume: 68, Issue:2

    Topics: Aldosterone; Blood Pressure; Blood Pressure Determination; California; Ethnicity; Female; Genetic Pr

2016
Genetic characterization of a mouse line with primary aldosteronism.
    Journal of molecular endocrinology, 2017, Volume: 58, Issue:2

    Topics: Aldosterone; Animals; Biomarkers; Disease Models, Animal; Exome; Female; Genetic Association Studies

2017
High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension.
    American journal of hypertension, 2017, 05-01, Volume: 30, Issue:5

    Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Black People; Blood Pressure; Cytochrome P-450

2017
High aldosterone-to-renin variants of CYP11B2 and pregnancy outcome.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:6

    Topics: Adult; Aldosterone; Base Sequence; Blood Pressure; Case-Control Studies; Cytochrome P-450 CYP11B2; D

2009
Hypertension, insulin resistance, and aldosterone: sex-specific relationships.
    Journal of clinical hypertension (Greenwich, Conn.), 2009, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aldosterone; Anthropometry; Black or African American; Blood Glucose

2009
Metabolic syndrome in primary aldosteronism and essential hypertension: relationship to adiponectin gene variants.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2010, Volume: 20, Issue:2

    Topics: Adiponectin; Aldosterone; Biomarkers; Blood Glucose; Chi-Square Distribution; Cross-Sectional Studie

2010
CYP11B2 gene haplotypes independently and in concurrence with aldosterone and aldosterone to renin ratio increase the risk of hypertension.
    Clinical biochemistry, 2010, Volume: 43, Issue:1-2

    Topics: Adult; Aged; Aldosterone; Cytochrome P-450 CYP11B2; Genetic Predisposition to Disease; Haplotypes; H

2010
Aldosterone-producing adenomas: mining for genes.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:6

    Topics: Adenoma; Adrenal Cortex Neoplasms; Aldosterone; Female; Genetic Predisposition to Disease; Genetic T

2010
Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.
    Urology, 2010, Volume: 76, Issue:4

    Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Adult; Aldosterone; China; Cytochro

2010
A mother/daughter case of familial hyperaldosteronism.
    Clinical cardiology, 2010, Volume: 33, Issue:12

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aldosterone; Antihypertensive Agents; Biomarkers; Blo

2010
A genome-wide association study of hypertension-related phenotypes in a Japanese population.
    Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:11

    Topics: Adult; Aged; Alcohol Drinking; Aldosterone; Asian People; Biomarkers; Blood Pressure; Body Mass Inde

2010
Low abundance of sweat duct Cl- channel CFTR in both healthy and cystic fibrosis athletes with exceptionally salty sweat during exercise.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 300, Issue:3

    Topics: Adult; Aldosterone; Aquaporin 5; Bicycling; Biopsy; Case-Control Studies; Cystic Fibrosis; Cystic Fi

2011
Association of the aldosterone synthase gene -344T>C polymorphism with essential hypertension and glucose homeostasis: a case-control study in a Han Chinese population.
    Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:9

    Topics: Aldosterone; Asian People; Blood Glucose; Blood Pressure; Case-Control Studies; China; Cytochrome P-

2011
The epistasis between vascular homeostasis genes is apparent in essential hypertension.
    Atherosclerosis, 2012, Volume: 220, Issue:2

    Topics: Adult; Aldosterone; Analysis of Variance; Blood Pressure; Case-Control Studies; Chi-Square Distribut

2012
Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:3

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; DNA, Neoplasm; Female; G Protein-Coup

2012
The epithelial Na+ channel: progressing from Liddle's syndrome to essential hypertension.
    Journal of hypertension, 2003, Volume: 21, Issue:5

    Topics: Aldosterone; Black People; Disease Progression; Genetic Predisposition to Disease; Humans; Hypertens

2003
A new mutation, R563Q, of the beta subunit of the epithelial sodium channel associated with low-renin, low-aldosterone hypertension.
    Journal of hypertension, 2003, Volume: 21, Issue:5

    Topics: Adult; Aged; Aldosterone; Amino Acid Sequence; Biomarkers; Black People; Female; Genetic Predisposit

2003
Association of high-altitude systemic hypertension with the deletion allele-of the angiotensin-converting enzyme (ACE) gene.
    International journal of biometeorology, 2003, Volume: 48, Issue:1

    Topics: Adaptation, Physiological; Adult; Aldosterone; Altitude; Case-Control Studies; Gene Deletion; Geneti

2003
Effects of static magnetic fields on plasma levels of angiotensin II and aldosterone associated with arterial blood pressure in genetically hypertensive rats.
    Bioelectromagnetics, 2003, Volume: 24, Issue:6

    Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, Radiation; Electro

2003
Genetic determinants of nonmodulating hypertension.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:5

    Topics: Age Factors; Aldosterone; Angiotensin II; Angiotensinogen; Epistasis, Genetic; Family Health; Female

2003
Increased renovascular response to angiotensin II in persons genetically predisposed to arterial hypertension disappears after chronic angiotensin-converting enzyme inhibition.
    Journal of hypertension, 2004, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Biomarkers

2004
Six missense mutations of the epithelial sodium channel beta and gamma subunits in Japanese hypertensives.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2004, Volume: 27, Issue:5

    Topics: Aged; Aldosterone; Asian People; Epithelial Sodium Channels; Exons; Female; Genetic Predisposition t

2004
Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension.
    BMC medical genetics, 2005, Jan-20, Volume: 6

    Topics: Adult; Aged; Aldosterone; Alleles; Epithelial Sodium Channels; Female; Genetic Predisposition to Dis

2005
Analysis of renin-angiotensin-aldosterone system gene polymorphisms in resistant hypertension.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2007, Volume: 40, Issue:3

    Topics: Aldosterone; Brazil; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease

2007
Diastolic dysfunction is associated with insulin resistance, but not with aldosterone level in normotensive offspring of hypertensive families.
    Cardiology, 2008, Volume: 111, Issue:1

    Topics: Adult; Aldosterone; Case-Control Studies; Female; Genetic Predisposition to Disease; Heart Failure,

2008
Translational research goes both ways: lessons from clinical studies.
    Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:4

    Topics: Aldosterone; Amino Acid Sequence; Antihypertensive Agents; Biomedical Research; Clinical Trials as T

2008
The angiotensin I converting enzyme gene and predisposition to high blood pressure.
    Hypertension (Dallas, Tex. : 1979), 1993, Volume: 21, Issue:4

    Topics: Adult; Aldosterone; Alleles; Angiotensin II; Blood Pressure; Diastole; Family; Female; Genetic Predi

1993
The role of blood pressure and aldosterone in the production of hemorrhagic stroke in captopril-treated hypertensive rats.
    Stroke, 1997, Volume: 28, Issue:9

    Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Cerebral

1997
Molecular variations in the calcium-sensing receptor in relation to sodium balance and presence of hypertension in blacks and whites.
    American journal of hypertension, 2000, Volume: 13, Issue:6 Pt 1

    Topics: Adolescent; Adult; Aldosterone; Black People; Blood Pressure; Blood Pressure Monitoring, Ambulatory;

2000
Genetic variation of the gamma subunit of the epithelial Na+ channel and essential hypertension. Relationship with salt sensitivity.
    American journal of hypertension, 2000, Volume: 13, Issue:6 Pt 1

    Topics: Adult; Aldosterone; Blood Pressure; Blood Pressure Monitoring, Ambulatory; DNA; DNA Primers; Epithel

2000
Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats.
    Journal of hypertension, 2001, Volume: 19, Issue:3 Pt 2

    Topics: Aldosterone; Animals; Cardiovascular System; Diet; Genetic Predisposition to Disease; Hypertension;

2001
Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 281, Issue:3

    Topics: Aldosterone; Animals; Aorta; Basal Ganglia; Blood Pressure; Body Weight; Cerebral Cortex; Cerebral I

2001