aldosterone and Electrolytes studies

Electrolytes: Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)

Research Excerpts

Excerpt	Relevance	Reference
"The effects of sacubitril/valsartan (S/V) on the renin-angiotensin-aldosterone system (RAAS) in dogs with cardiomegaly secondary to myxomatous mitral valve disease (MMVD) are currently unknown."	9.27	A prospective, randomized, double-blind, placebo-controlled pilot study of sacubitril/valsartan (Entresto) in dogs with cardiomegaly secondary to myxomatous mitral valve disease. ( Duran, SH; Jung, S; Newhard, DK; Winter, RL, 2018)
"Our primary objective was to compare the effects of three different doses of candoxatrilat with the effects of placebo on urinary volume in patients with moderately severe heart failure."	9.08	Renal response to candoxatrilat in patients with heart failure. ( Cleland, JG; Good, JM; Jackson, N; Oakley, CM; Peters, M; Wilkins, M, 1995)
"Eight patients with stable asthma weaned off beta2-agonist therapy were studied in a randomized, double-blinded, placebo-controlled study utilizing aerosolized terbutaline, 400 microg q6h."	9.08	Hemodynamic, cardiac, and electrolyte effects of low-dose aerosolized terbutaline sulfate in asthmatic patients. ( Braden, GL; Bria, WF; Germain, MJ; Hafer, JG; Mulhern, JG, 1998)
"The effect of hypoxia on plasma atrial natriuretic factor (ANF), plasma renin activity (PRA), and plasma aldosterone concentration (PAC) was evaluated during 2 h of treadmill exercise at 2 km/h, 0 grade at sea level."	9.07	Atrial natriuretic factor during hypoxia and mild exercise. ( Bowes, G; Miller, BR; Shield, CM; Story, DA, 1991)
"This presentation is a summary of our recent clinical studies on the therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism."	9.05	The therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism. ( Griffing, GT; Melby, JC, 1983)
" Plasma renin activity (PRA), the daily urinary excretion of aldosterone (dU-Aldo) and electrolytes were studied before and during dihydralazine therapy (25 mg 3 times daily)."	9.04	The renin-aldosterone system in dihydralazine therapy during hypertensive pregnancy. ( Lammintausta, R, 1978)
"The antihypertensive effect of the selective beta-1-adrenoceptor blocker, metoprolol, administered once daily was evaluated in 32 patients with primary hypertension."	9.04	Once-daily metoprolol in primary hypertension. ( Karlberg, BE; Nilsson, O; Nitelius, E; Tolagen, K; Waern, U, 1979)
"The renal mechanisms responsible for angiotensin II (ANG II)-induced hypertension remain incompletely understood."	7.81	Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension. ( Li, XC; Miguel-Qin, E; Shull, GE; Zhuo, JL, 2015)
" Blood pressure, heart rate, concentrations of aldosterone, urea, creatinine, electrolytes, and protein, index of hypertrophy of visceral organs, and 24-h diuresis were evaluated."	7.74	Effect of spironolactone on hypertrophy of left ventricular myocardium in wistar rats with experimental uremia. ( Beresneva, ON; Esaian, AM; Karabayeva, AZh; Kayukov, IG; Kotenko, LV; Parastaeva, MM; Sevastyanova, IE, 2008)
"Furosemide shortened the time to left ventricular dysfunction (35."	7.72	Furosemide and the progression of left ventricular dysfunction in experimental heart failure. ( Haigney, MC; Hanlon, SU; McCurley, JM; Michalski, M; Wedam, EF; Wei, SK, 2004)
" Tsukuba hypertensive mice (THM) carry both human renin and angiotensinogen genes, and develop hypertension."	7.69	Development of polyuria in Tsukuba hypertensive mice carrying human renin and angiotensinogen genes. ( Fukamizu, A; Ikemoto, F; Mino, N; Murakami, K; Nishikibe, M; Tsuchida, M; Uehara, S, 1995)
"Renal tubular acidification function was studied in 12 patients treated with cyclosporine (Cy) for idiopathic uveitis (IU) and in 5 patients with IU not treated with Cy."	7.68	Effects of cyclosporine on tubular acidification function in patients with idiopathic uveitis. ( Aguilera, S; Benhmida, M; Deray, G; Desjobert, H; Jacobs, C; Le Hoang, P, 1992)
"The effect of manidipine on cardiac hypertrophy, coronary circulation, left ventricular weight and maximal coronary flow in hypertension was measured in DOCA/salt treated systolic hypertensive rats with and without manidipine treatment."	7.68	Effect of manidipine on cardiac hypertrophy and coronary circulation in DOCA/salt hypertensive rats. ( Asayama, J; Itoh, H; Kuwabara, T; Nakagawa, M; Nakata, T; Sasaki, S; Takeda, K; Takesako, T; Tanabe, S; Yamahara, Y, 1992)
"To evaluate the importance of an endogenous sodium pump inhibitor in the pathogenesis of low renin human hypertension, the urinary excretion of a digoxin-like immunoreactive substance (DLIS) was measured in eight patients with primary aldosteronism (n = 5, with adenomas) during two sequential 1-week periods of low- (20 mmol/l NaCl) and high- (200 mmol/l NaCl) sodium intake."	7.68	Does a digoxin-like substance participate in vascular and pressure control during dietary sodium changes in patients with primary aldosteronism? ( Clerico, A; Del Chicca, MG; Graziadei, L; Panarace, G; Pedrinelli, R; Salvetti, A; Spessot, M; Taddei, S, 1991)
"A single dose of doxazosin, a long-acting postsynaptic alpha 1-adrenoceptor antagonist, was administered to seven patients with essential hypertension."	7.67	Antihypertensive effects and pharmacokinetics of single and consecutive administration of doxazosin in patients with mild to moderate essential hypertension. ( Kaneko, Y; Miyajima, E; Miyakawa, T; Shionoiri, H; Takagi, N; Umemura, S; Yasuda, G; Yoshimura, H, 1987)
"The relationship between atrial natriuretic factor (ANF), the renin-aldosterone axis, and blood pressure reduction with weight loss was investigated in 18 obese subjects (five hypertensive and 13 normotensive) placed on a 12-week, low-sodium (40 mmol), weight-reducing diet."	7.67	Weight reduction decreases atrial natriuretic factor and blood pressure in obese patients. ( McMurray, RW; Vesely, DL, 1989)
"Thirteen patients with hypertension and normal renal function received nitrendipine, a calcium entry blocker."	7.67	Nitrendipine, a calcium-entry blocker. Renal and humoral effects in human arterial hypertension. ( Bravo, EL; Fouad, FM; Pedrinelli, R; Tarazi, RC; Textor, SC, 1986)
"We investigated atrial natriuretic factor (ANF) in humans, measuring plasma immunoreactive (ir) ANF (in femtomoles per milliliter), and renal, hormonal, and hemodynamic responses to ANF infusion, in normal subjects (NL) and congestive heart failure patients (CHF)."	7.67	Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion. ( Atlas, SA; Camargo, MJ; Clark, M; Cody, RJ; Covit, AB; Kubo, SH; Laragh, JH; Pondolfino, K; Ryman, KS; Shaknovich, A, 1986)
"We studied the effects of furosemide on plasma renin and plasma aldosterone in 8 patients with mild to moderate congestive heart failure."	7.67	Acute changes in plasma renin activity, plasma aldosterone concentration and plasma electrolyte concentrations following furosemide administration in patients with congestive heart failure--interrelationships and diuretic response. ( Mulder, H; Schopman, W; van der Lely, AJ, 1987)
"Acute effects of 200 mg of orally given 4-[2-(methylamino)ethyl]-o-phenylene diisobutyrate hydrochloride (ibopamine hydrochloride) which is a new diisobutyric ester of N-methyldopamine, on hemodynamics and metabolism were evaluated in 11 patients with severe heart failure (New York Heart Association class IV)."	7.67	Acute effects of ibopamine hydrochloride on hemodynamics, plasma catecholamine levels, renin activity, aldosterone, metabolism and blood gas in patients with severe congestive heart failure. ( Kakuta, Y; Kanamaru, M; Kodera, T; Konishi, T; Morimoto, Y; Nakano, T; Takezawa, H, 1986)
"Plasma concentrations of arginine vasopressin (AVP), angiotensin II (AII), aldosterone (Aldo), urinary output (V), osmolar clearance (Cosm), free water clearance (CH2O), fractional excretions of sodium (FENa) and potassium (FEK), urinary sodium excretion rate (U-Na) and serum potassium (S-K) were determined in 9 patients with essential hypertension (group I) and 13 normotensive healthy control subjects (group II) before and three times during the first 4 hours after an intravenous injection of 40 mg of furosemide."	7.67	Abnormal vasopressin and aldosterone response to furosemide in essential hypertension. ( Danielsen, H; Madsen, M; Pedersen, EB; Sørensen, SS; Thomsen, OO, 1986)
"To define the short-term haemodynamic, hormonal and electrolyte effects of enalapril in chronic heart failure, we administered it to nine patients."	7.66	Acute haemodynamic, hormonal and electrolyte effects and short-term clinical response to enalapril in heart failure. ( Espiner, EA; Fitzpatrick, D; Ikram, H; Nicholls, MG, 1983)
"We investigated changes in the renin-angiotensin-aldosterone system in seven patients with essential hypertension during treatment with captopril (SQ 14225) (300 to 450 mg/day) for 12 months."	7.66	Captopril in the long-term treatment of essential hypertension: changes in the renin-angiotensin-aldosterone system. ( Hayduk, K; Liebau, G; Riegger, GA; Steilner, H, 1982)
"Captopril was given for treatment of hypertension alone or in combination with diuretics to 32 patients for 1- to 4-mo periods."	7.66	Long-term effects of captopril in hypertension. ( Hata, T; Iwanaga, K; Kumahara, Y; Maruyama, A; Mikami, H; Naka, T; Nakamaru, M; Ogihara, T, 1980)
"The effect of 5 to 9 days of metyrapone administration (400 mg/m2 every 4 h) on aldosterone, deoxycorticosterone, plasma renin activity, electrolyte balance, and blood pressure was investigated in 2 normotensive siblings (one of whom showed limited ACTH reserve), in 3 patients with hypertension and dexamethasone-suppressible hyperaldosteronism, and in a hypertensive patient with primary hyperaldosteronism due to bilateral adrenal hyperplasia."	7.66	Mineralocorticoid and metabolic response to metyrapone on normotensive children and children with dexamethasone-suppressible and primary hyperaldosteronism. ( Levine, LS; New, MI; Sonino, N, 1981)
"Urinary excretion of electrolytes and uric acid was investigated in six healthy subjects during repeated oral administration of 100 mg hydroflumethiazide (HFT) daily for seven days, and related to urinary thiazide excretion."	7.66	Effect of repeated doses of hydroflumethiazide on renal excretion of electrolytes and uric acid in healthy subjects. ( Aakvaag, A; Brørs, O; Foss, OP; Jacobsen, S, 1981)
"The effect of hydroflumethiazide (HFT) on renal excretion of sodium, chloride, and potassium was studied in congestive heart failure and related to urinary excretion of thiazide and aldosterone."	7.66	Effects of hydroflumethiazide in congestive heart failure: renal electrolyte excretion related to urinary thiazide excretion and aldosterone. ( Aakvaag, A; Brørs, O; Enger, E; Foss, OP; Jacobsen, S, 1981)
"Plasma concentrations of angiotensin II (AII) were studied in 36 patients with primary (essential) hypertension and 15 normotensive control subjects during basal (1 h supine rest), upright and frusemide-stimulated (80 mg orally) conditions."	7.66	Angiotensin II in primary hypertension, relationship to plasma renin activity, aldosterone and urinary electrolytes. ( Karlberg, BE; Tolagen, K, 1979)
"In order to evaluate the relationship between aldosterone status and the blood pressure-lowering effect of spironolactone, 38 patients with essential hypertension were treated with spironolactone (400 mg/day) during one week in hospital on a rigidly sodium-restricted diet."	7.66	Role of aldosterone in the antihypertensive effect of spironolactone in essential hypertension. ( Benraad, H; Benraad, T; Drayer, J; Hoefnagels, W; Kloppenborg, P, 1978)
" Midodrine and octreotide were dosed to obtain a stable increase of at least 15 mm Hg of mean arterial pressure."	6.69	Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide. ( Amodio, P; Angeli, P; Caregaro, L; Craighero, R; Gatta, A; Gerunda, G; Maffei-Faccioli, A; Merenda, R; Roner, P; Sticca, A; Volpin, R, 1999)
"In captopril-treated patients, the supine aldosterone levels exceeded the normal range and were as high as in placebo-treated patients."	6.66	Aldosterone and prolactin responsiveness after prolonged treatment of congestive heart failure with captopril. ( Althoff, PH; Bussmann, WD; Fassbinder, W; Hadler, D; Jungmann, E; Kaltenbach, M; Schöffling, K; Störger, H, 1985)
"In patients with chronic renal failure, decrement in BP was 25/16 mmHg (systolic and diastolic BP, respectively)."	6.65	[Hypotensive properties of nisoldipine. Comparative study in essential, renal and renovascular hypertension]. ( Breuer, G; Kaufmann, W; Wambach, G, 1984)
"Among these, classic primary hyperaldosteronism and its glucocorticoid remediable variety, in which hypertension is secondary to aldosterone production, must be considered."	6.40	[Hypertension and mineralocorticoids. Usefulness of renin and aldosterone measurements]. ( Fardella, CE; Montero, J; Mosso, L, 1999)
"Cardiac fibrosis is linked to aldosterone-induced hypertension, but the effects on in vivo left ventricular (LV) function are not established."	5.30	In vivo left ventricular function and collagen expression in aldosterone/salt-induced hypertension. ( Charlemagne, D; Delcayre, C; Lechat, P; Mougenot, N; Ramirez-Gil, JF; Robert, V; Trouve, P; Wassef, M, 1998)
"It is shown that acute alcoholic intoxication causes essential changes of aldosterone content and balance of electrolytes in blood plasma of Wistar rat males."	5.28	[Aldosterone and electrolyte content in blood and myocardium of rats after single physical load in acute alcoholic intoxication]. ( Antonov, AR; Iakobson, GS; Nacharov, IuV; Sorokin, AS, 1992)
"The data used to make the diagnosis of primary hyperaldosteronism and to assess the likelihood of the presence of an adenoma indicate that patients studied at 40 centres in the UK show results very similar to those of North American series where large numbers of patients have been described but all have been studied in the same centre."	5.28	Primary hyperaldosteronism in England and Wales: a review of the use of a Supraregional Assay Service laboratory for the measurement of aldosterone and plasma renin activity. ( James, VH; Short, F, 1991)
" The purpose of the present study was to examine whether long-term therapy with ramipril (RA, and ACE inhibitor) would lower blood pressure more effectively and without adverse reactions in combination with the loop diuretics piretanide (PI) or furosemide (FU)."	5.28	Loop diuretics combined with an ACE inhibitor for treatment of hypertension: a study with furosemide, piretanide, and ramipril in spontaneously hypertensive rats. ( Baldes, L; Becker, RH; Treudler, M, 1989)
"Bopindolol was given to hypertensive patients in a single daily dose ranging from 1 to 4 mg."	5.28	Bopindolol: long-term effects on blood pressure, renal function, plasma renin activity, and plasma aldosterone in mild-to-moderate essential hypertension. ( Modan, M; Rosenfeld, JB; Shohat, J, 1989)
"The effects of sacubitril/valsartan (S/V) on the renin-angiotensin-aldosterone system (RAAS) in dogs with cardiomegaly secondary to myxomatous mitral valve disease (MMVD) are currently unknown."	5.27	A prospective, randomized, double-blind, placebo-controlled pilot study of sacubitril/valsartan (Entresto) in dogs with cardiomegaly secondary to myxomatous mitral valve disease. ( Duran, SH; Jung, S; Newhard, DK; Winter, RL, 2018)
"Twenty-four patients with primary aldosteronism were studied."	5.26	Fludrocortisone suppression test in normal subjects, in patients with essential hypertension and in patients with various forms of aldosteronism. ( Lund, JO; Nielsen, MD, 1980)
"In four patients with complete quadriplegia, the mean values of serum sodium and potassium concentrations, haematocrit, plasma renin activity and plasma aldosterone slightly decreased immediately after the beginning of the GI infusion."	5.26	Changes in plasma renin activity and plasma aldosterone in the induced paralytic attack of thyrotroxic periodic paralysis. ( Miyamori, I; Morimoto, S; Takeda, R; Uchida, K, 1976)
"Our primary objective was to compare the effects of three different doses of candoxatrilat with the effects of placebo on urinary volume in patients with moderately severe heart failure."	5.08	Renal response to candoxatrilat in patients with heart failure. ( Cleland, JG; Good, JM; Jackson, N; Oakley, CM; Peters, M; Wilkins, M, 1995)
"Eight patients with stable asthma weaned off beta2-agonist therapy were studied in a randomized, double-blinded, placebo-controlled study utilizing aerosolized terbutaline, 400 microg q6h."	5.08	Hemodynamic, cardiac, and electrolyte effects of low-dose aerosolized terbutaline sulfate in asthmatic patients. ( Braden, GL; Bria, WF; Germain, MJ; Hafer, JG; Mulhern, JG, 1998)
" While urinary Na+ and Cl- were significantly increased while on salt tablets, urinary volume, K+, urea and creatinine concentrations, blood pressure, body weight, salivary and plasma electrolyte concentrations were unchanged."	5.07	Preferred salt levels and salt taste acuity in human subjects after ingestion of untasted salt. ( Di Nicolantonio, R; Huggins, RL; Morgan, TO, 1992)
"The effect of hypoxia on plasma atrial natriuretic factor (ANF), plasma renin activity (PRA), and plasma aldosterone concentration (PAC) was evaluated during 2 h of treadmill exercise at 2 km/h, 0 grade at sea level."	5.07	Atrial natriuretic factor during hypoxia and mild exercise. ( Bowes, G; Miller, BR; Shield, CM; Story, DA, 1991)
"To investigate the pathogenetic constellation and its modification by calcium channel blockade in hypertension associated with chronic nonoliguric renal failure, blood pressure (BP), various pressor factors or correlates, cardiovascular responsiveness, and plasma atrial natriuretic peptide (ANP) were assessed in 15 hypertensive patients (serum creatinine 160-715 mumol/l) before and after 6 weeks of intervention with the agent nitrendipine."	5.06	Hypertensive dysregulation and its modification by calcium channel blockade in nonoliguric renal failure. ( Bürgisser, E; Ferrier, C; Gnädinger, MP; Jahn, H; Schohn, D; Weidmann, P, 1989)
" To investigate this, 75 out-patients with essential hypertension were treated with chlorthalidone 12."	5.06	Plasma renin activity does not predict the antihypertensive efficacy of chlorthalidone. ( Bartolomei, G; Cagianelli, MA; Cinotti, G; Innocenti, P; Loni, C; Papi, L; Pedrinelli, R; Saba, G; Saba, P; Salvetti, A, 1987)
"This presentation is a summary of our recent clinical studies on the therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism."	5.05	The therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism. ( Griffing, GT; Melby, JC, 1983)
" Plasma renin activity (PRA), the daily urinary excretion of aldosterone (dU-Aldo) and electrolytes were studied before and during dihydralazine therapy (25 mg 3 times daily)."	5.04	The renin-aldosterone system in dihydralazine therapy during hypertensive pregnancy. ( Lammintausta, R, 1978)
"The antihypertensive effect of the selective beta-1-adrenoceptor blocker, metoprolol, administered once daily was evaluated in 32 patients with primary hypertension."	5.04	Once-daily metoprolol in primary hypertension. ( Karlberg, BE; Nilsson, O; Nitelius, E; Tolagen, K; Waern, U, 1979)
"Fluid-regulating hormones [arginine vasopressin (AVP) and aldosterone] as well as electrolytes, plasma volume (PV), and plasma proteins were studied in 16 well-trained male amateur runners (mean age 31."	4.77	Influence of prolonged physical exercise on plasma volume, plasma proteins, electrolytes, and fluid-regulating hormones. ( Altenkirch, HU; Heyduck, B; Kirsch, KA; Röcker, L, 1989)
"The renal mechanisms responsible for angiotensin II (ANG II)-induced hypertension remain incompletely understood."	3.81	Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension. ( Li, XC; Miguel-Qin, E; Shull, GE; Zhuo, JL, 2015)
" Patients with IIH should be evaluated for aldosteronism and considered for spironolactone therapy."	3.79	Idiopathic intracranial hypertension associated with either primary or secondary aldosteronism. ( Khalid, H; Khan, MU; Salpietro, V; Weber, KT, 2013)
" Blood pressure, heart rate, concentrations of aldosterone, urea, creatinine, electrolytes, and protein, index of hypertrophy of visceral organs, and 24-h diuresis were evaluated."	3.74	Effect of spironolactone on hypertrophy of left ventricular myocardium in wistar rats with experimental uremia. ( Beresneva, ON; Esaian, AM; Karabayeva, AZh; Kayukov, IG; Kotenko, LV; Parastaeva, MM; Sevastyanova, IE, 2008)
"Furosemide shortened the time to left ventricular dysfunction (35."	3.72	Furosemide and the progression of left ventricular dysfunction in experimental heart failure. ( Haigney, MC; Hanlon, SU; McCurley, JM; Michalski, M; Wedam, EF; Wei, SK, 2004)
"0 mg elemental potassium chloride (KCl) per kilogram body weight."	3.70	Potassium supplements' effect on potassium balance in athletes during prolonged hypokinetic and ambulatory conditions. ( Afonin, VB; Charapakhin, KP; Denogradov, SD; Kakurin, VJ; Zorbas, YG, 2000)
" Urinary excretion rates of calcium, sodium, chloride, potassium, urinary calcium/creatinine index, the fractional excretion of sodium, potassium and uric acid, the creatinine clearance and serum values of creatinine, urea, uric acid, electrolytes, total proteins, parathormone (intact molecule), plasma renin activity, aldosterone, glucose, and insulin (fasting and after an oral glucose load) were performed in every patient and control subject."	3.69	Urinary calcium excretion in treated and untreated essential hypertension. ( Navarro-Antolin, J; Orte, L; Ortuño, J; Quereda, C; Sabater, J; Villafruela, JJ, 1996)
" Tsukuba hypertensive mice (THM) carry both human renin and angiotensinogen genes, and develop hypertension."	3.69	Development of polyuria in Tsukuba hypertensive mice carrying human renin and angiotensinogen genes. ( Fukamizu, A; Ikemoto, F; Mino, N; Murakami, K; Nishikibe, M; Tsuchida, M; Uehara, S, 1995)
"Renal tubular acidification function was studied in 12 patients treated with cyclosporine (Cy) for idiopathic uveitis (IU) and in 5 patients with IU not treated with Cy."	3.68	Effects of cyclosporine on tubular acidification function in patients with idiopathic uveitis. ( Aguilera, S; Benhmida, M; Deray, G; Desjobert, H; Jacobs, C; Le Hoang, P, 1992)
"The effect of manidipine on cardiac hypertrophy, coronary circulation, left ventricular weight and maximal coronary flow in hypertension was measured in DOCA/salt treated systolic hypertensive rats with and without manidipine treatment."	3.68	Effect of manidipine on cardiac hypertrophy and coronary circulation in DOCA/salt hypertensive rats. ( Asayama, J; Itoh, H; Kuwabara, T; Nakagawa, M; Nakata, T; Sasaki, S; Takeda, K; Takesako, T; Tanabe, S; Yamahara, Y, 1992)
"To evaluate the importance of an endogenous sodium pump inhibitor in the pathogenesis of low renin human hypertension, the urinary excretion of a digoxin-like immunoreactive substance (DLIS) was measured in eight patients with primary aldosteronism (n = 5, with adenomas) during two sequential 1-week periods of low- (20 mmol/l NaCl) and high- (200 mmol/l NaCl) sodium intake."	3.68	Does a digoxin-like substance participate in vascular and pressure control during dietary sodium changes in patients with primary aldosteronism? ( Clerico, A; Del Chicca, MG; Graziadei, L; Panarace, G; Pedrinelli, R; Salvetti, A; Spessot, M; Taddei, S, 1991)
"01) plasma 18-hydroxycorticosterone (18-OHB) responses to upright posture, isometric handgrip exercise, furosemide administration and angiotensin II infusion without altering supine blood pressure, electrolytes or plasma cortisol."	3.67	Role of dopamine in the regulation of aldosterone and 18-hydroxycorticosterone secretion in man. ( Beck, FW; Sowers, JR, 1984)
"A single dose of doxazosin, a long-acting postsynaptic alpha 1-adrenoceptor antagonist, was administered to seven patients with essential hypertension."	3.67	Antihypertensive effects and pharmacokinetics of single and consecutive administration of doxazosin in patients with mild to moderate essential hypertension. ( Kaneko, Y; Miyajima, E; Miyakawa, T; Shionoiri, H; Takagi, N; Umemura, S; Yasuda, G; Yoshimura, H, 1987)
"The relationship between atrial natriuretic factor (ANF), the renin-aldosterone axis, and blood pressure reduction with weight loss was investigated in 18 obese subjects (five hypertensive and 13 normotensive) placed on a 12-week, low-sodium (40 mmol), weight-reducing diet."	3.67	Weight reduction decreases atrial natriuretic factor and blood pressure in obese patients. ( McMurray, RW; Vesely, DL, 1989)
" Parameters measured included blood pressure, blood chemistry (serum creatinine, uric acid, blood urea nitrogen, blood glucose total cholesterol, and electrolytes), plasma renin activity, and plasma aldosterone concentration."	3.67	Effects of nicardipine on blood pressure and renal function in elderly hypertensive patients with renal dysfunction. ( Saruta, T, 1989)
"Thirteen patients with hypertension and normal renal function received nitrendipine, a calcium entry blocker."	3.67	Nitrendipine, a calcium-entry blocker. Renal and humoral effects in human arterial hypertension. ( Bravo, EL; Fouad, FM; Pedrinelli, R; Tarazi, RC; Textor, SC, 1986)
"We investigated atrial natriuretic factor (ANF) in humans, measuring plasma immunoreactive (ir) ANF (in femtomoles per milliliter), and renal, hormonal, and hemodynamic responses to ANF infusion, in normal subjects (NL) and congestive heart failure patients (CHF)."	3.67	Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion. ( Atlas, SA; Camargo, MJ; Clark, M; Cody, RJ; Covit, AB; Kubo, SH; Laragh, JH; Pondolfino, K; Ryman, KS; Shaknovich, A, 1986)
"We studied the effect of chronic hypoxia on the renin, adrenocorticotropin (ACTH), aldosterone, and corticosterone responses to acute hemorrhage in conscious male rats with chronic femoral arterial catheters."	3.67	Renin, ACTH, and adrenocortical function during hypoxia and hemorrhage in conscious rats. ( Raff, H; Sandri, RB; Segerson, TP, 1986)
" Values for serum and urinary calcium, phosphorus, magnesium and electrolytes, creatinine clearance, plasma immunoreactive parathyroid hormone, and serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were similar in both study groups on each diet."	3.67	Normal vitamin D and mineral metabolism in essential hypertension. ( Bell, NH; Epstein, S; Hughes, GS; Margolius, HS; Oexmann, MJ, 1988)
"Hyperkalemic flaccid quadriplegia and cardiotoxic disturbances developed during antihypertensive therapy with spironolactone in a 76-year-old woman with chronic renal insufficiency."	3.67	Successful treatment of hyperkalemic quadriplegia associated with spironolactone. ( Radó, JP, 1988)
"To clarify the diuretic response to furosemide in a diseased state, the urinary excretion of furosemide, water, and electrolytes was examined after a single intravenous injection of furosemide in control rats and rats with mild acute renal failure (ARF) induced by glycerol."	3.67	Increased diuretic response to furosemide in rats with glycerol-induced acute renal failure. ( Hayashi, Y; Hori, R; Huang, Y; Inui, K; Kamiya, A; Kikkoji, T, 1988)
"The effects of a calcium antagonist [Nicardipine hydrochloride (NH)] on the prostaglandin [prostaglandin E2 (PGE2), and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha)] and thromboxane B2 levels in the blood and urine were examined in 6 patients with essential hypertension following intravenous infusion of NH for 120 minutes."	3.67	Effects of intravenous administration of a calcium antagonist on prostaglandins and thromboxane in plasma and urine in humans. ( Fukuda, N; Hatano, M; Honda, M; Izumi, Y; Manabe, R; Minato, M; Watanabe, M, 1986)
"We studied the effects of furosemide on plasma renin and plasma aldosterone in 8 patients with mild to moderate congestive heart failure."	3.67	Acute changes in plasma renin activity, plasma aldosterone concentration and plasma electrolyte concentrations following furosemide administration in patients with congestive heart failure--interrelationships and diuretic response. ( Mulder, H; Schopman, W; van der Lely, AJ, 1987)
"Acute effects of 200 mg of orally given 4-[2-(methylamino)ethyl]-o-phenylene diisobutyrate hydrochloride (ibopamine hydrochloride) which is a new diisobutyric ester of N-methyldopamine, on hemodynamics and metabolism were evaluated in 11 patients with severe heart failure (New York Heart Association class IV)."	3.67	Acute effects of ibopamine hydrochloride on hemodynamics, plasma catecholamine levels, renin activity, aldosterone, metabolism and blood gas in patients with severe congestive heart failure. ( Kakuta, Y; Kanamaru, M; Kodera, T; Konishi, T; Morimoto, Y; Nakano, T; Takezawa, H, 1986)
"Plasma concentrations of arginine vasopressin (AVP), angiotensin II (AII), aldosterone (Aldo), urinary output (V), osmolar clearance (Cosm), free water clearance (CH2O), fractional excretions of sodium (FENa) and potassium (FEK), urinary sodium excretion rate (U-Na) and serum potassium (S-K) were determined in 9 patients with essential hypertension (group I) and 13 normotensive healthy control subjects (group II) before and three times during the first 4 hours after an intravenous injection of 40 mg of furosemide."	3.67	Abnormal vasopressin and aldosterone response to furosemide in essential hypertension. ( Danielsen, H; Madsen, M; Pedersen, EB; Sørensen, SS; Thomsen, OO, 1986)
"Ovarian hyperstimulation syndrome occurred after induction of ovulation with menotropins (follicle-stimulating hormone and luteinizing hormone) and implantation of an intrauterine pregnancy."	3.67	Pathophysiology of the ovarian hyperstimulation syndrome. ( Haning, RV; Nolten, WE; Strawn, EY, 1985)
" Plasma and urinary electrolytes and epinephrine, plasma renin activity and aldosterone levels, pressor responsiveness to angiotensin II, the chronotropic responses to isoproterenol, and the NE-induced rise in BP, plasma clearance of NE, glomerular filtration rate and effective renal plasma flow were not consistently modified."	3.67	Cardiovascular regulation during administration of co-dergocrine to normal subjects. ( Gerber, A; Laederach, K; Weidmann, P, 1986)
"To define the short-term haemodynamic, hormonal and electrolyte effects of enalapril in chronic heart failure, we administered it to nine patients."	3.66	Acute haemodynamic, hormonal and electrolyte effects and short-term clinical response to enalapril in heart failure. ( Espiner, EA; Fitzpatrick, D; Ikram, H; Nicholls, MG, 1983)
"We investigated changes in the renin-angiotensin-aldosterone system in seven patients with essential hypertension during treatment with captopril (SQ 14225) (300 to 450 mg/day) for 12 months."	3.66	Captopril in the long-term treatment of essential hypertension: changes in the renin-angiotensin-aldosterone system. ( Hayduk, K; Liebau, G; Riegger, GA; Steilner, H, 1982)
"Captopril was given for treatment of hypertension alone or in combination with diuretics to 32 patients for 1- to 4-mo periods."	3.66	Long-term effects of captopril in hypertension. ( Hata, T; Iwanaga, K; Kumahara, Y; Maruyama, A; Mikami, H; Naka, T; Nakamaru, M; Ogihara, T, 1980)
"The effect of 5 to 9 days of metyrapone administration (400 mg/m2 every 4 h) on aldosterone, deoxycorticosterone, plasma renin activity, electrolyte balance, and blood pressure was investigated in 2 normotensive siblings (one of whom showed limited ACTH reserve), in 3 patients with hypertension and dexamethasone-suppressible hyperaldosteronism, and in a hypertensive patient with primary hyperaldosteronism due to bilateral adrenal hyperplasia."	3.66	Mineralocorticoid and metabolic response to metyrapone on normotensive children and children with dexamethasone-suppressible and primary hyperaldosteronism. ( Levine, LS; New, MI; Sonino, N, 1981)
"Urinary excretion of electrolytes and uric acid was investigated in six healthy subjects during repeated oral administration of 100 mg hydroflumethiazide (HFT) daily for seven days, and related to urinary thiazide excretion."	3.66	Effect of repeated doses of hydroflumethiazide on renal excretion of electrolytes and uric acid in healthy subjects. ( Aakvaag, A; Brørs, O; Foss, OP; Jacobsen, S, 1981)
"The effect of hydroflumethiazide (HFT) on renal excretion of sodium, chloride, and potassium was studied in congestive heart failure and related to urinary excretion of thiazide and aldosterone."	3.66	Effects of hydroflumethiazide in congestive heart failure: renal electrolyte excretion related to urinary thiazide excretion and aldosterone. ( Aakvaag, A; Brørs, O; Enger, E; Foss, OP; Jacobsen, S, 1981)
"Angiotensin II (Ile5) was infused for 72 h into 4 sodium replete (3 ng/kg/min) and 8 sodium deplete (3 or 6 ng/kg/min) healthy young men after appropriate control periods, and the effects on aldosterone secretion, plasma cortisol, ACTH, renin activity, plasma and urinary electrolytes, and blood pressure were assessed."	3.66	Prolonged infusions of Ile5-angiotensin-II in sodium replete and deplete man: effects on aldosterone, ACTH, cortisol, blood pressure, and electrolyte balance. ( Bauer, B; Fehm, HL; L'age, M; Oelkers, W; Schöneshöfer, M; Schultze, G; Wenzler, M, 1978)
"Plasma concentrations of angiotensin II (AII) were studied in 36 patients with primary (essential) hypertension and 15 normotensive control subjects during basal (1 h supine rest), upright and frusemide-stimulated (80 mg orally) conditions."	3.66	Angiotensin II in primary hypertension, relationship to plasma renin activity, aldosterone and urinary electrolytes. ( Karlberg, BE; Tolagen, K, 1979)
"Studies on plasma aldosterone, total serum protein, electrolytes, osmolal concentrations in serum and urine, creatinine, lithium and osmolal clearances were carried out on 14 patients suffering from lithium intoxication."	3.66	Renal function and plasma aldosterone during acute lithium intoxication. ( Amdisen, A; Hansen, HE; Pedersen, EB, 1979)
"In order to evaluate the relationship between aldosterone status and the blood pressure-lowering effect of spironolactone, 38 patients with essential hypertension were treated with spironolactone (400 mg/day) during one week in hospital on a rigidly sodium-restricted diet."	3.66	Role of aldosterone in the antihypertensive effect of spironolactone in essential hypertension. ( Benraad, H; Benraad, T; Drayer, J; Hoefnagels, W; Kloppenborg, P, 1978)
"In 79 patients with essential hypertension, treatment with propranolol hydrochloride and chlorthalidone together produced significantly greater falls in both systolic and diastolic blood pressures than were obtained with either drug alone."	3.65	Renin reactivity as a determinant of responsiveness to antihypertensive treatment. ( Case, DB; Drayer, JI; Laragh, JH; Lopez-Ovejero, JA; Weber, MA, 1977)
"In both groups, hyperinsulinemia caused a decrease in blood volume (0."	2.70	Defective regulation and action of atrial natriuretic peptide in type 2 diabetes. ( Baldi, S; Catalano, C; Ferrannini, E; Nannipieri, M; Prontera, T; Seghieri, G, 2002)
" Midodrine and octreotide were dosed to obtain a stable increase of at least 15 mm Hg of mean arterial pressure."	2.69	Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide. ( Amodio, P; Angeli, P; Caregaro, L; Craighero, R; Gatta, A; Gerunda, G; Maffei-Faccioli, A; Merenda, R; Roner, P; Sticca, A; Volpin, R, 1999)
" Urinary electrolytes and aldosterone were measured for the 24 h before dosing and for 24 h after dosing."	2.68	Comparison of the oral angiotensin II receptor antagonist UP 269-6 or enalapril 20 mg on blood pressure and neurohormonal effects in salt-deplete man. ( Brunner, HR; Insuasty, J; MacFadyen, RJ; McIntyre, M; Menard, J; Meredith, PA; Reid, JL, 1995)
" In this protocol after salt depletion, losartan caused a transient increase in urea and creatinine (143 +/- 40 microML) 8 h after dosing as compared with placebo (105 +/- 13 microM)."	2.68	Haemodynamic and renal responses to oral losartan potassium during salt depletion or salt repletion in normal human volunteers. ( Doig, JK; MacFadyen, RJ; Reid, JL; Sweet, CS, 1995)
"The purpose of the present study was to define the dose-response relationship between exogenous dopamine and systemic haemodynamics, renal haemodynamics, and renal excretory function at infusion rates in the range 0 to 12."	2.68	Dopamine natriuresis in salt-repleted, water-loaded humans: a dose-response study. ( Bonde, J; Kanstrup, IL; Leyssac, PP; Olsen, MH; Olsen, NV; Plum, I; Strandgaard, S, 1997)
" Our results indicate a BP and plasma renin dose-response relation for the orally active angiotensin II (AII) receptor blocker losartan in normotensive subjects with an activated RAS."	2.67	Dose-ranging study of the angiotensin type I receptor antagonist losartan (DuP753/MK954), in salt-deplete normal man. ( Doig, JK; Lees, KR; MacFadyen, RJ; Reid, JL; Sweet, CS, 1993)
"Losartan or a placebo was administered to 23 subjects maintained on a high-sodium (200 mmol/d) or a low-sodium (50 mmol/d) diet in a randomized, double-blind, crossover study."	2.67	Salt-dependent renal effects of an angiotensin II antagonist in healthy subjects. ( Brunner, HR; Burnier, M; Nussberger, J; Rutschmann, B; Shahinfar, S; Versaggi, J; Waeber, B, 1993)
" Thus, this long-term study provides additional evidence that diuretics have a flat dose-response curve with respect to their antihypertensive efficacy, whereas lower doses might cause less pronounced activation of counter-regulatory systems."	2.67	Long-term diuretic therapy: effects of dose reduction on antihypertensive efficacy and counterregulatory systems. ( Ripka, O; Weisser, B, 1992)
" The possibility of an acute pharmacokinetic or pharmacodynamic interaction between the ACE inhibitor ramipril and the calcium antagonist felodipine was examined in 12 normotensive male volunteers."	2.67	A study of the acute pharmacodynamic interaction of ramipril and felodipine in normotensive subjects. ( Bainbridge, AD; Lees, KR; MacFadyen, RJ; Reid, JL, 1991)
"In captopril-treated patients, the supine aldosterone levels exceeded the normal range and were as high as in placebo-treated patients."	2.66	Aldosterone and prolactin responsiveness after prolonged treatment of congestive heart failure with captopril. ( Althoff, PH; Bussmann, WD; Fassbinder, W; Hadler, D; Jungmann, E; Kaltenbach, M; Schöffling, K; Störger, H, 1985)
"In patients with chronic renal failure, decrement in BP was 25/16 mmHg (systolic and diastolic BP, respectively)."	2.65	[Hypotensive properties of nisoldipine. Comparative study in essential, renal and renovascular hypertension]. ( Breuer, G; Kaufmann, W; Wambach, G, 1984)
"Mycophenolic acid was detected in all cats."	2.61	( Abrams, G; Adolfsson, E; Agarwal, PK; Akkan, AG; Al Alhareth, NS; Alves, VGL; Armentano, R; Bahroos, E; Baig, M; Baldridge, KK; Barman, S; Bartolucci, C; Basit, A; Bertoli, SV; Bian, L; Bigatti, G; Bobenko, AI; Boix, PP; Bokulic, T; Bolink, HJ; Borowiec, J; Bulski, W; Burciaga, J; Butt, NS; Cai, AL; Campos, AM; Cao, G; Cao, Y; Čapo, I; Caruso, ML; Chao, CT; Cheatum, CM; Chelminski, K; Chen, AJW; Chen, C; Chen, CH; Chen, D; Chen, G; Chen, H; Chen, LH; Chen, R; Chen, RX; Chen, X; Cherdtrakulkiat, R; Chirvony, VS; Cho, JG; Chu, K; Ciurlino, D; Coletta, S; Contaldo, G; Crispi, F; Cui, JF; D'Esposito, M; de Biase, S; Demir, B; Deng, W; Deng, Z; Di Pinto, F; Domenech-Ximenos, B; Dong, G; Drácz, L; Du, XJ; Duan, LJ; Duan, Y; Ekendahl, D; Fan, W; Fang, L; Feng, C; Followill, DS; Foreman, SC; Fortunato, G; Frew, R; Fu, M; Gaál, V; Ganzevoort, W; Gao, DM; Gao, X; Gao, ZW; Garcia-Alvarez, A; Garza, MS; Gauthier, L; Gazzaz, ZJ; Ge, RS; Geng, Y; Genovesi, S; Geoffroy, V; Georg, D; Gigli, GL; Gong, J; Gong, Q; Groeneveld, J; Guerra, V; Guo, Q; Guo, X; Güttinger, R; Guyo, U; Haldar, J; Han, DS; Han, S; Hao, W; Hayman, A; He, D; Heidari, A; Heller, S; Ho, CT; Ho, SL; Hong, SN; Hou, YJ; Hu, D; Hu, X; Hu, ZY; Huang, JW; Huang, KC; Huang, Q; Huang, T; Hwang, JK; Izewska, J; Jablonski, CL; Jameel, T; Jeong, HK; Ji, J; Jia, Z; Jiang, W; Jiang, Y; Kalumpha, M; Kang, JH; Kazantsev, P; Kazemier, BM; Kebede, B; Khan, SA; Kiss, J; Kohen, A; Kolbenheyer, E; Konai, MM; Koniarova, I; Kornblith, E; Krawetz, RJ; Kreouzis, T; Kry, SF; Laepple, T; Lalošević, D; Lan, Y; Lawung, R; Lechner, W; Lee, KH; Lee, YH; Leonard, C; Li, C; Li, CF; Li, CM; Li, F; Li, J; Li, L; Li, S; Li, X; Li, Y; Li, YB; Li, Z; Liang, C; Lin, J; Lin, XH; Ling, M; Link, TM; Liu, HH; Liu, J; Liu, M; Liu, W; Liu, YP; Lou, H; Lu, G; Lu, M; Lun, SM; Ma, Z; Mackensen, A; Majumdar, S; Martineau, C; Martínez-Pastor, JP; McQuaid, JR; Mehrabian, H; Meng, Y; Miao, T; Miljković, D; Mo, J; Mohamed, HSH; Mohtadi, M; Mol, BWJ; Moosavi, L; Mosdósi, B; Nabu, S; Nava, E; Ni, L; Novakovic-Agopian, T; Nyamunda, BC; Nyul, Z; Önal, B; Özen, D; Özyazgan, S; Pajkrt, E; Palazon, F; Park, HW; Patai, Á; Patai, ÁV; Patzke, GR; Payette, G; Pedoia, V; Peelen, MJCS; Pellitteri, G; Peng, J; Perea, RJ; Pérez-Del-Rey, D; Popović, DJ; Popović, JK; Popović, KJ; Posecion, L; Povall, J; Prachayasittikul, S; Prachayasittikul, V; Prat-González, S; Qi, B; Qu, B; Rakshit, S; Ravelli, ACJ; Ren, ZG; Rivera, SM; Salo, P; Samaddar, S; Samper, JLA; Samy El Gendy, NM; Schmitt, N; Sekerbayev, KS; Sepúlveda-Martínez, Á; Sessolo, M; Severi, S; Sha, Y; Shen, FF; Shen, X; Shen, Y; Singh, P; Sinthupoom, N; Siri, S; Sitges, M; Slovak, JE; Solymosi, N; Song, H; Song, J; Song, M; Spingler, B; Stewart, I; Su, BL; Su, JF; Suming, L; Sun, JX; Tantimavanich, S; Tashkandi, JM; Taurbayev, TI; Tedgren, AC; Tenhunen, M; Thwaites, DI; Tibrewala, R; Tomsejm, M; Triana, CA; Vakira, FM; Valdez, M; Valente, M; Valentini, AM; Van de Winckel, A; van der Lee, R; Varga, F; Varga, M; Villarino, NF; Villemur, R; Vinatha, SP; Vincenti, A; Voskamp, BJ; Wang, B; Wang, C; Wang, H; Wang, HT; Wang, J; Wang, M; Wang, N; Wang, NC; Wang, Q; Wang, S; Wang, X; Wang, Y; Wang, Z; Wen, N; Wesolowska, P; Willis, M; Wu, C; Wu, D; Wu, L; Wu, X; Wu, Z; Xia, JM; Xia, X; Xia, Y; Xiao, J; Xiao, Y; Xie, CL; Xie, LM; Xie, S; Xing, Z; Xu, C; Xu, J; Yan, D; Yan, K; Yang, S; Yang, X; Yang, XW; Ye, M; Yin, Z; Yoon, N; Yoon, Y; Yu, H; Yu, K; Yu, ZY; Zhang, B; Zhang, GY; Zhang, H; Zhang, J; Zhang, M; Zhang, Q; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhang, YW; Zhang, Z; Zhao, D; Zhao, F; Zhao, P; Zhao, W; Zhao, Z; Zheng, C; Zhi, D; Zhou, C; Zhou, FY; Zhu, D; Zhu, J; Zhu, Q; Zinyama, NP; Zou, M; Zou, Z, 2019)
"Hyporeninemic hypoaldosteronism is the mechanism causing the electrolyte disbalance reported in patients with RMND1 mutations, and can be treated."	2.44	Hyporeninemic hypoaldosteronism in RMND1-related mitochondrial disease. ( Beck, BB; Dijkman, H; Gracchi, V; Kömhoff, M; Monnens, L, 2024)
"Among these, classic primary hyperaldosteronism and its glucocorticoid remediable variety, in which hypertension is secondary to aldosterone production, must be considered."	2.40	[Hypertension and mineralocorticoids. Usefulness of renin and aldosterone measurements]. ( Fardella, CE; Montero, J; Mosso, L, 1999)
"The various types of renal tubular acidosis have manifold facets but the basic understanding of their pathophysiology begins with the concept of the "anion gap," a point of reference that can be used in the differential diagnosis and treatment."	2.36	Acid-base disorders and the kidney. ( Chan, JC, 1983)
"To assess pharmacokinetic and pharmacodynamic parameters of torasemide in healthy cats, and to investigate the effects of a single administration of torasemide on indicators of diuresis, plasma creatinine concentration, blood pressure, electrolyte concentrations and markers of the renin-angiotensin-aldosterone system (RAAS)."	1.72	Pharmacokinetic and pharmacodynamic properties of orally administered torasemide in healthy cats. ( Broeckx, BJG; de Salazar Alcala, AG; Devreese, M; Hellemans, A; Paepe, D; Roche-Catholy, M; Schneider, M; Smets, P; Woehrlé, F, 2022)
" The objectives of this study were to evaluate pharmacodynamic markers of furosemide-induced diuresis and to investigate mechanisms of diuretic braking in dogs receiving constant rate infusion (CRI) of furosemide."	1.48	Pharmacodynamic assessment of diuretic efficacy and braking in a furosemide continuous infusion model. ( Adin, D; Atkins, C; Papich, MG, 2018)
"Primary hyperaldosteronism as compared to other renin angiotensin aldosterone system disorders was found to be the leading cause of hypertension in young population."	1.48	Spectrum of renin angiotensin aldosterone system disorders in young hypertensives. ( Akram, A; Asif, N; Gilani, M; Ijaz, A; Malik, SS, 2018)
"Aldosterone is a major mineralocorticoid hormone that plays a key role in the regulation of blood pressure and is implicated in the pathogenesis of hypertension and heart failure."	1.46	Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice. ( Du, N; Du, Y; Gu, H; Kowala, MC; Ma, Z; Shatara, A; Wang, J; Yi, X; Zhu, T, 2017)
"Celecoxib (40 mg/kg) was co-administered once daily to one vehicle and one misoprostol group from days 3 to 9."	1.40	Exacerbation of celecoxib-induced renal injury by concomitant administration of misoprostol in rats. ( Bullins, KW; Campbell, GE; Conder, CM; Cooper, DL; Denham, JW; Hanley, AV; Harirforoosh, S; Lynch, SP; Murrell, DE; Palau, VE; Panus, PC; Singh, K, 2014)
"Renal pseudohypoaldosteronism type 1 is a rare autosomal-dominant disease caused by NR3C2 loss-of-function mutations, which is characterized by renal salt loss and compensatory high renin and aldo secretion."	1.39	Cardiovascular effects of aldosterone: insight from adult carriers of mineralocorticoid receptor mutations. ( Chillon, S; Couffignal, C; Escoubet, B; Jeunemaitre, X; Laisy, JP; Laouénan, C; Mangin, L; Mentré, F; Serfaty, JM; Zennaro, MC, 2013)
"Moreover, the hyperaldosteronism was partially reversed by Ca(2+)-deficient diet."	1.36	Hyperaldosteronism in Klotho-deficient mice. ( Ackermann, TF; Boini, KM; Fischer, SS; Föller, M; Hocher, B; Kempe, DS; Kuro-O, M; Lang, F; Leibrock, CB; Rexhepaj, R; Rosenblatt, KP; Siraskar, B, 2010)
"To evaluate the prevalence of left ventricular hypertrophy (LVH) and left ventricular geometry in a group of 293 hypertensive patients with stage 2-5 chronic kidney disease (CKD), compared with 289 essential hypertensive patients with normal renal function."	1.35	Left ventricular hypertrophy and geometry in hypertensive patients with chronic kidney disease. ( Cerasola, G; Cottone, S; Cusimano, P; Mulè, G; Nardi, E; Palermo, A, 2009)
" Angiotensin II dose-response curves were studied in rat perfused pressurized small-diameter arteries in the presence of losartan (AT1R antagonist)."	1.33	High-salt diet inhibits expression of angiotensin type 2 receptor in resistance arteries. ( Castillo, F; Galleguillos, L; Gonzalez, M; Lobos, L; Lopez, NC; Michea, L, 2005)
"In contrast, the AS-/- mice have low blood pressure, abnormal electrolyte homeostasis (increased plasma concentrations of K+, Ca2+, and Mg2+ and decreased concentrations of HCO3(-) and Cl- but no difference in the plasma Na+ level), and disturbances in water metabolism (higher urine output, decreased urine osmolality, and impaired urine concentrating and diluting ability)."	1.33	Kidney function in mice lacking aldosterone. ( Gomez, RA; Kim, HS; Lee, G; Makhanova, N; Sequeira Lopez, ML; Smithies, O; Takahashi, N, 2006)
"The Liddle syndrome is a dominant form of salt-sensitive hypertension resulting from mutations in the beta or gamma subunit of ENaC."	1.32	Dysfunction of the epithelial sodium channel expressed in the kidney of a mouse model for Liddle syndrome. ( Bens, M; Gautschi, I; Hummler, E; Loffing, J; Pradervand, S; Rossier, BC; Schild, L; Vandewalle, A, 2003)
" When stimulated with phenylephrine, aortic smooth muscle from Nkcc1(+/+) and Nkcc1(-/-) mice exhibited no significant differences in maximum contractility and only moderate dose-response shifts."	1.31	Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter. ( Flagella, M; Lorenz, JN; Meyer, JW; Nieman, ML; Paul, RJ; Shull, GE; Sutliff, RL; Weber, CS, 2002)
"Pseudohypoaldosteronism was diagnosed on the basis of hyponatremia, severe urinary salt loss despite the markedly elevated serum aldosterone up to 6,500 pg/ml (normal range 50-800 pg/ml)."	1.31	Pseudohypoaldosteronism: mineralocorticoid unresponsiveness syndrome. ( Janjindamai, W; Jaruratanasirikul, S, 2000)
"Aldosterone plays a major role in regulating sodium and potassium flux in epithelial tissues such as kidney and colon."	1.31	The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action. ( Bhargava, A; Cole, TJ; Fullerton, MJ; Funder, JW; Myles, K; Pearce, D; Purdy, TM, 2001)
"Aldosterone levels were variable."	1.31	Hyponatremia in the postoperative craniofacial pediatric patient population: a connection to cerebral salt wasting syndrome and management of the disorder. ( Bradley, JP; Levine, JP; McCarthy, JG; Stelnicki, E; Weiner, HL, 2001)
"Cardiac fibrosis is linked to aldosterone-induced hypertension, but the effects on in vivo left ventricular (LV) function are not established."	1.30	In vivo left ventricular function and collagen expression in aldosterone/salt-induced hypertension. ( Charlemagne, D; Delcayre, C; Lechat, P; Mougenot, N; Ramirez-Gil, JF; Robert, V; Trouve, P; Wassef, M, 1998)
"Severe dehydration without significant changes in plasma [Na+] could be detected after HM."	1.30	Plasma-electrolytes in natives to hypoxia after marathon races at different altitudes. ( Bernal, H; Böning, D; Garcia, O; Garcia, S; Rojas, J; Schmidt, W, 1999)
"Treatment with furosemide plus low-dose captopril increased plasma vasopressin but not plasma oxytocin."	1.29	Endocrine changes associated with a rapidly developing sodium appetite in rats. ( Johnson, AK; Morris, M; Thunhorst, RL, 1994)
"Aldosterone secretion was increased after the surgery in the L-group."	1.29	[Changes in the intraoperative hormonal homeostasis following infusion of lactated Ringer's solution with high potassium concentration]. ( Kimura, K; Takaori, M; Yoshida, H, 1994)
"Aldosterone concentration was extremely high (64."	1.29	An infant with pseudohypoaldosteronism accompanied by cholelithiasis. ( Hanaki, K; Iitsuka, T; Kaibara, N; Nagaishi, J; Nagata, I; Ohzeki, T; Shimizu, N; Shiraki, K; Tsukuda, T; Urashima, H, 1994)
"The thermal dehydration test was performed in 12 patients with renal transplant and in 20 healthy subjects."	1.28	[Effect of thermal dehydration on blood levels of hormones regulating volume and electrolyte content of sweat in patients with kidney transplantation]. ( Grzeszczak, W; Kokot, F; Wiecek, A; Woch, W; Zukowska-Szczechowska, E, 1992)
"It is shown that acute alcoholic intoxication causes essential changes of aldosterone content and balance of electrolytes in blood plasma of Wistar rat males."	1.28	[Aldosterone and electrolyte content in blood and myocardium of rats after single physical load in acute alcoholic intoxication]. ( Antonov, AR; Iakobson, GS; Nacharov, IuV; Sorokin, AS, 1992)
"The data used to make the diagnosis of primary hyperaldosteronism and to assess the likelihood of the presence of an adenoma indicate that patients studied at 40 centres in the UK show results very similar to those of North American series where large numbers of patients have been described but all have been studied in the same centre."	1.28	Primary hyperaldosteronism in England and Wales: a review of the use of a Supraregional Assay Service laboratory for the measurement of aldosterone and plasma renin activity. ( James, VH; Short, F, 1991)
"Aldosterone levels were significantly lowered below pretreatment values by the 1- and 2-mg twice daily doses."	1.28	Preliminary study of the treatment of advanced breast cancer in postmenopausal women with the aromatase inhibitor CGS 16949A. ( Coombes, RC; Davenport, J; Dowsett, M; Ford, HT; Gazet, JC; Hedley, A; Stein, RC, 1990)
" The purpose of the present study was to examine whether long-term therapy with ramipril (RA, and ACE inhibitor) would lower blood pressure more effectively and without adverse reactions in combination with the loop diuretics piretanide (PI) or furosemide (FU)."	1.28	Loop diuretics combined with an ACE inhibitor for treatment of hypertension: a study with furosemide, piretanide, and ramipril in spontaneously hypertensive rats. ( Baldes, L; Becker, RH; Treudler, M, 1989)
"25 mg, in 8 normal subjects before and after treatment with the selective alpha-2 adrenoceptor antagonist, yohimbine, at a maximal dosage of 60 mg daily."	1.28	Yohimbine and aldosterone responsiveness to angiotensin II or corticotrophin in normal subjects. ( Beretta-Piccoli, C; Kressebuch, H; Lucchini, E, 1989)
"Bopindolol was given to hypertensive patients in a single daily dose ranging from 1 to 4 mg."	1.28	Bopindolol: long-term effects on blood pressure, renal function, plasma renin activity, and plasma aldosterone in mild-to-moderate essential hypertension. ( Modan, M; Rosenfeld, JB; Shohat, J, 1989)
"The combination of trisomy 21 and PHA is very unusual."	1.27	Pseudohypoaldosteronism in a child with Down syndrome. Long-term management of salt loss by ion exchange resin administration. ( Dörr, HG; Saule, H; Sippell, WG, 1984)
"In patients with Meniere's disease and sudden deafness, the walter-electrolyte balance results were normal, as were the hormonal system directly (renin-aldosterone) or indirectly (cortisol-ACTH) involved."	1.27	Fluid-solute regulation systems in patients with Meniere's disease. ( Bonnanni, G; Colletti, V; Pavarin, A; Sittoni, V, 1983)
"These findings suggested Bartter's syndrome."	1.27	Cystic fibrosis mimicking Bartter's syndrome. ( Davison, AG; Snodgrass, GJ, 1983)
"Fifteen patients with idiopathic hyperaldosteronism were examined."	1.27	[Clinical aspects, diagnosis and treatment of idiopathic hyperaldosteronism]. ( Babloian, GV; Kazanchian, PO; Litvinov, AP; Migalina, LA; Pokrovskiĭ, AV, 1984)
"Thirty-four patients with untreated Conn's syndrome were studied in a metabolic ward."	1.27	Relation of blood pressure with body and plasma electrolytes in Conn's syndrome. ( Beretta-Piccoli, C; Brown, JJ; Davies, DL; Ferriss, B; Fraser, R; Lasaridis, A; Lever, AF; Morton, JJ; Robertson, JI; Semple, PF, 1983)
" After chronic administration (7 days) of indoramin, no significant changes in blood pressure, renal function, renal hemodynamics, or fluid and electrolyte excretion were observed."	1.27	The acute and chronic effects of indoramin on renal function, hemodynamics, and transport. ( Goldfarb, S; Morrison, G; Spar, B; Walker, BR, 1986)
" It was investigated in rats whether chronic administration of bisacodyl reduces the effects of acute bisacodyl administration on net water and electrolyte flux in the rat colon transport in-vivo."	1.27	Influence of chronic bisacodyl treatment on the effect of acute bisacodyl on water and electrolyte transport in the rat colon. ( Beubler, E, 1985)
"Aldosterone (aldo) treatment of animals stimulates the rate of H+ secretion in the collecting duct, a process which may involve an H+-ATPase sensitive to inhibition by NEM (N-ethylmaleimide)."	1.27	Effects of aldosterone on NEM-sensitive ATPase in rabbit nephron segments. ( Garg, LC; Narang, N, 1988)
"Further volume expansion in liver cirrhosis by saline infusion led to the further increase in ANP (13."	1.27	Radioimmunoassay of atrial natriuretic peptide in human plasma: application to studies of volume and blood pressure homeostasis. ( Horký, K; Lachmanová, J; Srámková, J; Tesar, V; Widimský, J, 1988)
"Patients with pyelonephritic renal scarring are at risk of developing renal failure and hypertension."	1.27	Role of hypervolemia and renin in the blood pressure control of patients with pyelonephritis renal scarring. ( Jacobson, SH; Kjellstrand, CM; Lins, LE, 1988)
"Because hyponatremia is frequently associated with preceding diuretic treatment and unrestricted fluid intake--conditions which have not been addressed sufficiently in published literature--we studied the pathophysiology and the clinical setting of such hyponatremia in a large group of internal medicine patients."	1.27	Role of diuretics, hormonal derangements, and clinical setting of hyponatremia in medical patients. ( Gross, P; Hackenthal, E; Hausmann, C; Ketteler, M; Rascher, W; Reinhard, C; Ritz, E; Schömig, A, 1988)
"Furosemide was administered intravenously to four patients who had undergone renal transplantation in the past and four creatinine clearance--matched control subjects."	1.27	Furosemide pharmacokinetics and pharmacodynamics in renal transplantation. ( Brater, C; Davis, J; Fakhry, I; Gehr, TW; Sica, DA, 1988)
" In vitro dose-response curves to NE and TNS were not significantly different."	1.27	Effect of high calcium intake on pressor responsivity in hypertensive rats. ( Berger, M; Brickman, AS; Eggena, P; Golub, M; Lee, DB; Nyby, M; Stern, N; Tuck, ML, 1987)
"Patients with orthostatic hypotension, unlike control subjects, experienced an increase in total plasma dopamine (DA) (free + sulfate) in response to upright posture (p less than 0."	1.27	Orthostatic hypotension: a posture-induced hyperdopaminergic state. ( Bourque, M; Buu, NT; Genest, J; Gutkowska, J; Hamet, P; Kuchel, O; Larochelle, P; Schiffrin, EL, 1985)
"The association of achalasia, lack of lacrimation, and glucocorticoid deficiency in two pairs of siblings with normal mineralocorticoid activity has been recently reported."	1.26	Glucocorticoid and partial mineralocorticoid deficiency associated with achalasia. ( Bynum, TE; Casella, JF; Fox, CE; Kowarski, AA; Lanes, R; Lee, PA; Migeon, CJ; Plotnick, LP, 1980)
"Plasma aldosterone in the primary aldosteronism group increased significantly at 0."	1.26	Effects of angiotensin III and ACTH on aldosterone secretion. ( Luetscher, JA; Zager, PG, 1982)
"Twenty-four patients with primary aldosteronism were studied."	1.26	Fludrocortisone suppression test in normal subjects, in patients with essential hypertension and in patients with various forms of aldosteronism. ( Lund, JO; Nielsen, MD, 1980)
"In three children Bartter's syndrome was diagnosed on the basis of the typical laboratory findings and the characteristic histological changes of the kidney."	1.26	[Clinical findings, pathogenesis and treatment of Bartter's syndrome (author's transl)]. ( Ploier, R; Tulzer, W, 1981)
"I initiated acute respiratory acidosis with 10% CO2 inhalation in healthy mongrel dogs, and then plasma aldosterone concentration, plasma renin activity, electrolytes and cardiorenal hemodynamics were measured."	1.26	[The changes on plasma aldosterone concentration during acute respiratory acidosis in dogs. The relationship to renin-angiotensin system and electrolyte metabolism (author's transl)]. ( Sunada, K, 1982)
"Distal renal tubular acidosis has been thought to be the consequence of an impaired ability to maintain a large pH gradient between distal nephron urine and blood."	1.26	Mechanisms and classification of deranged distal urinary acidification. ( Arruda, JA; Kurtzman, NA, 1980)
"Aldosterone was not produced in the patient and the metabolic product of its immediate precursor, 18-hydroxy-11-dehydro-tetrahydrocorticosterone, was excreted in markedly elevated amounts."	1.26	17 alpha-Hydroxylase deficiency. A combination of hydroxylation defect and reversible blockade in aldosterone biosynthesis. ( Berlinger, FG; Cohen, EL; Conn, JW; Gordon, DL; Kem, DC; Rovner, DR, 1979)
"Hypokalemia was frequent both in the patients with low (7/11) and normal (3/6) potassium per kg lean body mass."	1.26	Electrolytes and whole body potassium in acute leukemia. ( Carlmark, B; Lantz, B; Reizenstein, P, 1979)
"Fourteen patients with sickle cell anemia, ages 6 to 20 years, were studied while ingesting high- and low-sodium diets."	1.26	Hyperreninemia and hyperaldosteronism in sickle cell anemia. ( Carpentieri, U; Corn, C; Matustik, MC; Meyer, WJ, 1979)
"In four patients with complete quadriplegia, the mean values of serum sodium and potassium concentrations, haematocrit, plasma renin activity and plasma aldosterone slightly decreased immediately after the beginning of the GI infusion."	1.26	Changes in plasma renin activity and plasma aldosterone in the induced paralytic attack of thyrotroxic periodic paralysis. ( Miyamori, I; Morimoto, S; Takeda, R; Uchida, K, 1976)

Research

Studies (681)

Authors

Clinical Trials (13)

Trial Overview

Trial Outcomes

Development of Post-paracentesis Circulatory Dysfunction (PCD)

Timeframe	Studies, this research(%)	All Research%
pre-1990	452 (66.37)	18.7374
1990's	127 (18.65)	18.2507
2000's	54 (7.93)	29.6817
2010's	42 (6.17)	24.3611
2020's	6 (0.88)	2.80

Authors	Studies
Pearce, D	2
Manis, AD	1
Nesterov, V	1
Korbmacher, C	1
Roche-Catholy, M	1
Paepe, D	1
Devreese, M	1
Broeckx, BJG	1
Woehrlé, F	1
Schneider, M	1
de Salazar Alcala, AG	1
Hellemans, A	1
Smets, P	1
Kömhoff, M	1
Gracchi, V	1
Dijkman, H	1
Beck, BB	1
Monnens, L	1
Woo, H	1
Han, A	1
Park, JE	1
Cha, YS	1
Bobenko, AI	1
Heller, S	1
Schmitt, N	1
Cherdtrakulkiat, R	1
Lawung, R	1
Nabu, S	1
Tantimavanich, S	1
Sinthupoom, N	1
Prachayasittikul, S	1
Prachayasittikul, V	1
Zhang, B	1
Wu, C	1
Zhang, Z	2
Yan, K	1
Li, C	2
Li, Y	4
Li, L	3
Zheng, C	1
Xiao, Y	1
He, D	1
Zhao, F	1
Su, JF	1
Lun, SM	1
Hou, YJ	1
Duan, LJ	1
Wang, NC	1
Shen, FF	1
Zhang, YW	1
Gao, ZW	1
Li, J	5
Du, XJ	1
Zhou, FY	1
Yin, Z	1
Zhu, J	2
Yan, D	1
Lou, H	1
Yu, H	1
Feng, C	1
Wang, Z	1
Wang, Y	6
Hu, X	2
Li, Z	2
Shen, Y	1
Hu, D	1
Chen, H	1
Wu, X	2
Duan, Y	1
Zhi, D	1
Zou, M	2
Zhao, Z	1
Zhang, X	2
Yang, X	2
Zhang, J	3
Wang, H	1
Popović, KJ	1
Popović, DJ	1
Miljković, D	1
Lalošević, D	1
Čapo, I	1
Popović, JK	1
Liu, M	1
Song, H	2
Xing, Z	1
Lu, G	1
Chen, D	1
Valentini, AM	1
Di Pinto, F	1
Coletta, S	1
Guerra, V	1
Armentano, R	1
Caruso, ML	1
Gong, J	1
Wang, N	1
Bian, L	1
Wang, M	1
Ye, M	1
Wen, N	1
Fu, M	1
Fan, W	1
Meng, Y	1
Dong, G	1
Lin, XH	1
Liu, HH	1
Gao, DM	1
Cui, JF	1
Ren, ZG	1
Chen, RX	1
Önal, B	1
Özen, D	1
Demir, B	1
Akkan, AG	1
Özyazgan, S	1
Payette, G	1
Geoffroy, V	1
Martineau, C	1
Villemur, R	1
Jameel, T	1
Baig, M	1
Gazzaz, ZJ	1
Tashkandi, JM	1
Al Alhareth, NS	1
Khan, SA	1
Butt, NS	1
Wang, J	3
Geng, Y	1
Zhang, Y	4
Wang, X	3
Liu, J	2
Basit, A	1
Miao, T	1
Liu, W	2
Jiang, W	1
Yu, ZY	1
Wu, L	2
Qu, B	1
Sun, JX	1
Cai, AL	1
Xie, LM	1
Groeneveld, J	1
Ho, SL	1
Mackensen, A	1
Mohtadi, M	1
Laepple, T	1
Genovesi, S	1
Nava, E	1
Bartolucci, C	1
Severi, S	1
Vincenti, A	1
Contaldo, G	1
Bigatti, G	1
Ciurlino, D	1
Bertoli, SV	1
Slovak, JE	1
Hwang, JK	1
Rivera, SM	1
Villarino, NF	1
Li, S	1
Cao, G	1
Ling, M	1
Ji, J	1
Zhao, D	1
Sha, Y	1
Gao, X	1
Liang, C	2
Guo, Q	2
Zhou, C	1
Ma, Z	2
Xu, J	1
Wang, C	1
Zhao, W	1
Xia, X	1
Jiang, Y	1
Peng, J	1
Jia, Z	1
Li, F	1
Chen, X	2
Mo, J	1
Zhang, S	2
Li, X	2
Huang, T	1
Zhu, Q	1
Wang, S	1
Ge, RS	1
Fortunato, G	1
Lin, J	2
Agarwal, PK	1
Kohen, A	1
Singh, P	1
Cheatum, CM	1
Zhu, D	1
Hayman, A	1
Kebede, B	1
Stewart, I	1
Chen, G	1
Frew, R	1
Guo, X	1
Gong, Q	1
Borowiec, J	1
Han, S	1
Zhang, M	1
Willis, M	1
Kreouzis, T	1
Yu, K	1
Chirvony, VS	1
Sekerbayev, KS	1
Pérez-Del-Rey, D	1
Martínez-Pastor, JP	1
Palazon, F	1
Boix, PP	1
Taurbayev, TI	1
Sessolo, M	1
Bolink, HJ	1
Lu, M	1
Lan, Y	1
Xiao, J	1
Song, M	1
Chen, C	1
Huang, Q	1
Cao, Y	1
Ho, CT	1
Qi, B	1
Wang, Q	1
Zhang, W	1
Fang, L	1
Xie, CL	1
Chen, R	1
Yang, S	1
Xia, JM	1
Zhang, GY	1
Chen, CH	1
Yang, XW	1
Domenech-Ximenos, B	1
Garza, MS	1
Prat-González, S	1
Sepúlveda-Martínez, Á	1
Crispi, F	1
Perea, RJ	1
Garcia-Alvarez, A	1
Sitges, M	1
Kalumpha, M	1
Guyo, U	1
Zinyama, NP	1
Vakira, FM	1
Nyamunda, BC	1
Varga, M	1
Drácz, L	1
Kolbenheyer, E	1
Varga, F	2
Patai, ÁV	1
Solymosi, N	1
Patai, Á	1
Kiss, J	1
Gaál, V	1
Nyul, Z	1
Mosdósi, B	1
Valdez, M	1
Moosavi, L	1
Heidari, A	1
Novakovic-Agopian, T	1
Kornblith, E	1
Abrams, G	1
McQuaid, JR	1
Posecion, L	1
Burciaga, J	1
D'Esposito, M	1
Chen, AJW	1
Samy El Gendy, NM	1
Wesolowska, P	1
Georg, D	1
Lechner, W	1
Kazantsev, P	1
Bokulic, T	1
Tedgren, AC	1
Adolfsson, E	1
Campos, AM	1
Alves, VGL	1
Suming, L	1
Hao, W	1
Ekendahl, D	1
Koniarova, I	1
Bulski, W	1
Chelminski, K	1
Samper, JLA	1
Vinatha, SP	1
Rakshit, S	1
Siri, S	1
Tomsejm, M	1
Tenhunen, M	1
Povall, J	1
Kry, SF	1
Followill, DS	1
Thwaites, DI	1
Izewska, J	1
Kang, JH	1
Yoon, Y	1
Song, J	2
Van de Winckel, A	1
Gauthier, L	1
Chao, CT	1
Lee, YH	1
Li, CM	1
Han, DS	1
Huang, JW	1
Huang, KC	1
Ni, L	1
Güttinger, R	1
Triana, CA	1
Spingler, B	1
Baldridge, KK	1
Patzke, GR	1
Shen, X	1
Wang, B	1
Xie, S	1
Deng, W	1
Wu, D	1
Zhang, Q	1
Voskamp, BJ	1
Peelen, MJCS	1
Ravelli, ACJ	1
van der Lee, R	1
Mol, BWJ	1
Pajkrt, E	1
Ganzevoort, W	1
Kazemier, BM	1
Tibrewala, R	1
Bahroos, E	1
Mehrabian, H	1
Foreman, SC	1
Link, TM	1
Pedoia, V	1
Majumdar, S	1
Jablonski, CL	1
Leonard, C	1
Salo, P	1
Krawetz, RJ	1
Yoon, N	1
Hong, SN	1
Cho, JG	1
Jeong, HK	1
Lee, KH	1
Park, HW	1
Barman, S	1
Konai, MM	1
Samaddar, S	1
Haldar, J	1
Mohamed, HSH	1
Li, CF	1
Hu, ZY	1
Deng, Z	1
Chen, LH	1
Su, BL	1
Chu, K	1
Liu, YP	1
Li, YB	1
Zhang, H	1
Xu, C	1
Zou, Z	1
Wu, Z	1
Xia, Y	1
Zhao, P	1
Wang, HT	1
de Biase, S	1
Pellitteri, G	1
Gigli, GL	1
Valente, M	1
Mabillard, H	2
Sayer, JA	2
Mandal, R	1
Kaur, S	1
Gupta, VK	1
Joshi, A	1
Gu, H	1
Zhu, T	1
Du, N	1
Shatara, A	1
Yi, X	1
Kowala, MC	1
Du, Y	1
Loh, SY	1
Giribabu, N	1
Salleh, N	1
Harvey, BJ	1
Thomas, W	1
Lee, JH	1
Adin, D	1
Atkins, C	1
Papich, MG	1
Kolodziejczyk, P	1
Gromotowicz-Poplawska, A	1
Aleksiejczuk, M	1
Chabielska, E	1
Tutka, P	1
Miltyk, W	1
Newhard, DK	1
Jung, S	1
Winter, RL	1
Duran, SH	1
Gilani, M	2
Asif, N	1
Akram, A	1
Ijaz, A	1
Malik, SS	1
Murck, H	1
Braunisch, MC	1
Konrad, C	1
Jezova, D	1
Kircher, T	1
Escoubet, B	1
Couffignal, C	1
Laisy, JP	1
Mangin, L	1
Chillon, S	1
Laouénan, C	1
Serfaty, JM	1
Jeunemaitre, X	1
Mentré, F	1
Zennaro, MC	2
Uchiyama, M	1
Maejima, S	1
Wong, MK	1
Preyavichyapugdee, N	1
Wanichanon, C	1
Hyodo, S	1
Takei, Y	1
Matuda, K	1
Liu, YZ	1
Wu, JJ	1
Zhang, L	1
Xu, H	1
Liu, Z	1
Lu, JP	1
Feng, L	1
Zhao, CM	1
Liu, JX	1
Wei, H	1
Cao, S	1
Zhao, H	2
Eladari, D	1
Chambrey, R	1
Picard, N	1
Hadchouel, J	1
Cooper, DL	1
Murrell, DE	1
Conder, CM	1
Palau, VE	1
Campbell, GE	1
Lynch, SP	1
Denham, JW	1
Hanley, AV	1
Bullins, KW	1
Panus, PC	1
Singh, K	1
Harirforoosh, S	1
de Morais, TL	1
Giribela, C	1
Nisenbaum, MG	1
Guerra, G	1
Mello, N	1
Baracat, E	1
Consolim-Colombo, FM	1
Sun, QL	1
Li, M	1
Rui, HL	1
Chen, YP	1
Desbrow, B	1
Cecchin, D	1
Jones, A	1
Grant, G	1
Irwin, C	1
Leveritt, M	1
Feng, X	1
Shao, N	1
Zhuang, Z	1
Wu, P	1
Lee, MJ	1
Liu, Y	1
Zhuang, J	1
Delpire, E	1
Gu, D	1
Cai, H	1
Li, XC	1
Shull, GE	3
Miguel-Qin, E	1
Zhuo, JL	1
Martinerie, L	1
Pussard, E	1
Yousef, N	1
Cosson, C	1
Lema, I	1
Husseini, K	1
Mur, S	1
Lombès, M	1
Boileau, P	1
Montes-Cobos, E	1
Fischer, HJ	1
Sasse, A	1
Kügler, S	1
Didié, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Double-blind Randomized Placebo Controlled Study on the Effect of Enoxolone ( 11-beta Hydroxysteroid-dehydrogenase Type 2 Inhibitor) on the RAAS, Autonomic and Imaging Biomarkers and the Outcome of Depression[NCT05570110]	Phase 1/Phase 2	60 participants (Anticipated)	Interventional	2022-09-23	Recruiting
Cardiovascular Evaluation of a Rare Condition With Hyperaldosteronism Without Hypertension: PHA 1[NCT00646828]		98 participants (Actual)	Observational	2008-05-31	Completed
PREMALDO : Aldosterone Resistance in Preterm Infants : Assessment by a Non Invasive Measurement of Urinary Aldosterone[NCT01176162]		170 participants (Actual)	Observational	2010-01-31	Completed
Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2)[NCT01942395]		18 participants (Actual)	Interventional	2012-09-18	Terminated (stopped due to study diet is no longer available to match with the previous participants.)
Effect of Spironolactone on the Progression of Coronary Calcification in Peritoneal Dialysis Patients[NCT03314493]	Phase 3	33 participants (Actual)	Interventional	2014-11-07	Completed
Renal Ageing-sarcopenia Network: a Combined Genetic, Immunological and Psychological Approach to Dissect Frailty[NCT04630132]		1,500 participants (Anticipated)	Observational	2017-03-25	Recruiting
A Blinded, Placebo Controlled Trial of Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis[NCT00368381]	Phase 4	0 participants (Actual)	Interventional	2006-09-30	Withdrawn (stopped due to Study closed for PI failure to submit renewal paperwork)
Open, Randomized, Unicenter Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease[NCT04626323]	Phase 2	60 participants (Anticipated)	Interventional	2021-05-25	Recruiting
Vasoconstrictors as Alternatives to Albumin After Large Volume Paracentesis in Cirrhosis[NCT00108355]	Phase 4	29 participants (Actual)	Interventional	2003-12-31	Completed
The Effect of Correction of Metabolic Acidosis in CKD on Intrarenal RAS Activity[NCT02896309]		45 participants (Actual)	Interventional	2016-09-30	Completed
Vasopressin Plasma Concentrations in Responders and Non-responders to Exogenous Vasopressin Infusion in Patients With Septic Shock[NCT03014063]		18 participants (Actual)	Observational	2016-11-30	Completed
Use of Arginine Vasopressin in Early Postoperative Management After Fontan Palliation[NCT03088345]	Phase 2/Phase 3	20 participants (Actual)	Interventional	2017-03-06	Completed
PHASE III RANDOMIZED CONTROL CASE STUDY OF LETROZOLE IN WOMEN WITH HEAVILY PRETREATED OVARIAN CANCER (MITO 32)[NCT04421547]	Phase 3	236 participants (Anticipated)	Interventional	2020-06-01	Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Defined as an increase in Plasma Renin Activity (PRA) by >50% from baseline to a level > 4 ng/mL/h at post-paracentesis day (NCT00108355)
Timeframe: 6 days after paracentesis

Time to Recurrence of Ascites.

Intervention	participants (Number)
Albumin (Control Group)	2
Vasoconstrictor (Treatment Group)	2

Comparison between Albumin (Control group) and Vasoconstrictor (Treatment group) (NCT00108355)
Timeframe: Variable depending on the patient, average 10 days

Hemodynamics as Characterized by Mean Arterial Pressure

Intervention	days (Median)
Albumin (Control Group)	10
Vasoconstrictor (Treatment Group)	8

Organ perfusion pressure measured as Mean Arterial Pressure (MAP). It will be measured hourly for 24 postoperative hours for all subjects and compared between the two study groups over the whole time of observation as the main between-group effect in panel regression. (NCT03088345)
Timeframe: 24 hours post-operative

Hemodynamics as Characterized by Transpulmonary Pressure Gradient

Intervention	mmHg (Mean)
Vasopressin, Arginine	67
Placebo	66

The transpulmonary pressure gradient (TPG), defined as the difference between mean pulmonary arterial pressure (Ppa) and left/common atrial (common atrial) pressure (Pla) will be measured hourly for 24 postoperative hours for all subjects and compared between the two study groups over the whole time of observation as the main between-group effect in panel regression. (NCT03088345)
Timeframe: 24 hours post-operative

Hemodynamics as Characterized by Vasoactive Inotrope Score (VIS)

Intervention	mmHg (Mean)
Vasopressin, Arginine	6.4
Placebo	8.3

The vasoactive inotrope score (VIS) is a linear sum of vasoactive and inotrope durg infusion doses. It is usually reported as dimensionless but is sometimes reported as normalized to dopamine mcg/kg/min equivalents. The score starts at 0 and has no defined upper limit, with a commonly observed range 0-50. It is used as a measure of the intensity of hemodynamic support, with higher scores indicating more vasoactive drug support for patients. The relationship of VIS to other patient outcomes is not consistent. It will be calculated hourly for all subjects and compared between groups over the entire observation timeframe. (NCT03088345)
Timeframe: 48 hours post-operative

Liver Dysfunction as Characterized by Transaminase Levels

Intervention	units (Mean)
Vasopressin, Arginine	11
Placebo	11.3

Transaminase levels (alanine and aspartate, measured in IU/L ) will be tracked for all patients and changes will be compared between study groups. (NCT03088345)
Timeframe: 48 hours post-operative

Renal Dysfunction as Characterized by Change in Cystatin Level

Intervention	iU/L (Mean)
Vasopressin, Arginine	715
Placebo	522

Cystatin levels will be measured at baseline (immediately before cardiopulmonary bypass) 24 hours postoperative. The change (postoperative minus baseline) in cystatin level will be compared between groups. (NCT03088345)
Timeframe: from baseline pre-cardiopulmonary bypass to 24 hours post-operative

Resource Utilization Measured by Length of Stay (LOS)

Intervention	mg/L (Mean)
Vasopressin, Arginine	0.095
Placebo	0.017

Length of stay (LOS) measured in postoperative hours compared between groups (NCT03088345)
Timeframe: from time of operation until hospital discharge

Article	Year
Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology. Pflugers Archiv : European journal of physiology, 2022, Volume: 474, Issue:8 Topics: Aldosterone; Electrolytes; Epithelial Sodium Channels; Homeostasis; Ion Transport; Kidney Tubules, D	2022
Proceedings. Mathematical, physical, and engineering sciences, 2019, Volume: 475, Issue:2227 Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P	2019
Electrolyte Disturbances in SARS-CoV-2 Infection. F1000Research, 2020, Volume: 9 Topics: Aldosterone; Betacoronavirus; Coronavirus Infections; COVID-19; Electrolytes; Humans; Hypokalemia; P	2020
Electrolyte Disturbances in SARS-CoV-2 Infection. F1000Research, 2020, Volume: 9 Topics: Aldosterone; Betacoronavirus; Coronavirus Infections; COVID-19; Electrolytes; Humans; Hypokalemia; P	2020
Electrolyte Disturbances in SARS-CoV-2 Infection. F1000Research, 2020, Volume: 9 Topics: Aldosterone; Betacoronavirus; Coronavirus Infections; COVID-19; Electrolytes; Humans; Hypokalemia; P	2020
Electrolyte Disturbances in SARS-CoV-2 Infection. F1000Research, 2020, Volume: 9 Topics: Aldosterone; Betacoronavirus; Coronavirus Infections; COVID-19; Electrolytes; Humans; Hypokalemia; P	2020
Aldosterone-induced protein kinase signalling and the control of electrolyte balance. Steroids, 2018, Volume: 133 Topics: Aldosterone; Animals; Electrolytes; Humans; Protein Kinases; Receptors, Mineralocorticoid; Signal Tr	2018
New Sides of Aldosterone Action in Cardiovascular System as Potential Targets for Therapeutic Intervention. Current drug targets, 2018, Volume: 19, Issue:16 Topics: Aldosterone; Animals; Cardiovascular Diseases; Cardiovascular System; Cell Nucleus; Cytoplasm; Disea	2018
Electroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation. Cellular and molecular life sciences : CMLS, 2014, Volume: 71, Issue:15 Topics: Aldosterone; Animals; Biological Transport; Blood Pressure; Electrolytes; Homeostasis; Humans; Nephr	2014
[Pathophysiology of Meniere's disease--point of views from the study on endolymphatic sac]. Nihon Jibiinkoka Gakkai kaiho, 2015, Volume: 118, Issue:11 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Biological Transport; Catecholamines; Diet	2015
Urinalysis: a review of methods and procedures. Critical care nursing clinics of North America, 2010, Volume: 22, Issue:1 Topics: Aldosterone; Chorionic Gonadotropin; Creatinine; Critical Care; Electrolytes; Humans; Hydrocortisone	2010
Pathophysiological roles of aldosterone and mineralocorticoid receptor in the kidney. Journal of pharmacological sciences, 2011, Volume: 115, Issue:1 Topics: Aldosterone; Animals; Blood Pressure; Electrolytes; Eplerenone; Homeostasis; Humans; Kidney; Kidney	2011
[CIRCULATORY DISEASES AND ELECTROLYTES]. [Chiryo] [Therapy], 1964, Volume: 46 Topics: Aldosterone; Digitalis; Digitalis Glycosides; Diuretics; Edema; Electrolytes; Heart Failure; Hypokal	1964
[THE WATER-ELECTROLYTE STATE IN EDEMA CAUSED BY CONGESTIVE CARDIO-CIRCULATORY INSUFFICIENCY. PHYSIOPATHOGENETIC CONSIDERATIONS AND THERAPEUTIC TRENDS]. La Rassegna di clinica, terapia e scienze affini, 1964, Volume: 63 Topics: Adrenal Cortex Hormones; Aldosterone; Chlorothiazide; Diet; Diet Therapy; Diuretics; Edema; Electrol	1964
KIDNEY, WATER AND ELECTROLYTES. Annual review of physiology, 1964, Volume: 26 Topics: Aldosterone; Amino Acids; Blood Circulation; Citrates; Creatine; Creatinine; Diuretics; Electrolytes	1964
[CURRENT INFORMATION ON THE ROLE OF THE RENAL-ADRENAL SYSTEM IN THE REGULATION OF BLOOD PRESSURE, ELECTROLYTES AND WATER METABOLISM]. Lekarska veda v zahranici, 1964, Jun-19, Volume: 103 Topics: Adrenal Glands; Aldosterone; Angiotensins; Blood Pressure; Blood Pressure Determination; Electrolyte	1964
[NEW DATA ON THE ETIOPATHOGENESIS OF ESSENTIAL ARTERIAL HYPERTENSION]. Studii si cercetari de medicina interna, 1965, Volume: 40 Topics: Aldosterone; Electrolytes; Essential Hypertension; Humans; Hypertension; Metabolism	1965
Effects of aldosterone and mineralocorticoid receptor blockade on intracellular electrolytes. Heart failure reviews, 2005, Volume: 10, Issue:1 Topics: Aldosterone; Animals; Electrolytes; Gene Expression; Humans; Intracellular Fluid; Mineralocorticoid	2005
Aldosterone--a hormone of cardiovascular adaptation and maladaptation. Journal of clinical hypertension (Greenwich, Conn.), 2006, Volume: 8, Issue:2 Topics: Aldosterone; Blood Pressure; Cardiovascular Diseases; Electrolytes; Homeostasis; Humans; Hypertensio	2006
Type 2 pseudohypoaldosteronism: new insights into renal potassium, sodium, and chloride handling. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 48, Issue:4 Topics: Adult; Aldosterone; Chlorides; Electrolytes; Humans; Hyperkalemia; Intracellular Signaling Peptides	2006
Disorders of the adrenal cortex: their effects on electrolyte metabolism. Clinics in endocrinology and metabolism, 1984, Volume: 13, Issue:2 Topics: Addison Disease; Adrenal Cortex Diseases; Adrenal Cortex Hormones; Adrenal Hyperplasia, Congenital;	1984
Plasma aldosterone regulation in anephric and non-nephrectomized patients on regular haemodialysis. A survey. Danish medical bulletin, 1980, Volume: 27, Issue:1 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Circadian Rhythm; Electrol	1980
Familial periodic paralysis with hypokalaemia. Experimental and clinical investigations. Danish medical bulletin, 1981, Volume: 28, Issue:1 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Child; Child, Preschool; Denmark;	1981
Hormonal regulation of electrolyte and water transport in the colon. Klinische Wochenschrift, 1984, Jun-15, Volume: 62, Issue:12 Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Biological Transport, Active; Body Water; Chlorides;	1984
Renal tubular acidosis. The Journal of pediatrics, 1983, Volume: 102, Issue:3 Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Aldosterone; Ammonia; Calcium; Carbon Dioxide; Carbo	1983
Acid-base disorders and the kidney. Advances in pediatrics, 1983, Volume: 30 Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Acidosis; Acidosis, Renal Tubular; Aldosterone; Alkalosi	1983
Metabolic and endocrine changes in spinal cord injury: II (section 2). Partial decentralization of the autonomic nervous system. Archives of physical medicine and rehabilitation, 1982, Volume: 63, Issue:11 Topics: Aldosterone; Autonomic Nervous System; Body Composition; Body Fluid Compartments; Electrolytes; Huma	1982
[Electrolytes]. Nihon rinsho. Japanese journal of clinical medicine, 1982, Volume: 40, Issue:9 Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Calcium; Chlorine; Electrolytes; Humans; Potassium; Rec	1982
[Influence of insulinfree rehydration on diabetic derangements (author's transl)]. Wiener klinische Wochenschrift, 1980, Sep-12, Volume: 92, Issue:17 Topics: Acidosis; Adolescent; Adult; Aged; Aldosterone; Blood Glucose; C-Peptide; Diabetes Mellitus; Electro	1980
Renin-angiotensin-aldosterone system for blood pressure and electrolyte homeostasis and its involvement in hypertension, in congestive heart failure and in associated cardiovascular damage (myocardial infarction and stroke). Journal of human hypertension, 1995, Volume: 9, Issue:6 Topics: Aldosterone; Animals; Blood Pressure; Cardiovascular Diseases; Cerebrovascular Disorders; Electrolyt	1995
Nongenomic aldosterone effects: the cell membrane as a specific target of mineralocorticoid action. Steroids, 1995, Volume: 60, Issue:1 Topics: Aldosterone; Animals; Biological Transport; Cell Membrane; Electrolytes; Genome, Human; Humans; Kidn	1995
Aldosterone-specific membrane receptors and related rapid, non-genomic effects. Trends in pharmacological sciences, 1993, Volume: 14, Issue:1 Topics: Aldosterone; Binding Sites; Biological Transport; Electrolytes; Gene Expression Regulation; Humans;	1993
[Molecular structure of renin-angiotensin-aldosterone system]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 1999, Volume: 6, Issue:34 Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Electrolytes; Gene Expression	1999
[Hypertension and mineralocorticoids. Usefulness of renin and aldosterone measurements]. Revista medica de Chile, 1999, Volume: 127, Issue:5 Topics: Aldosterone; Electrolytes; Humans; Hyperaldosteronism; Hypertension; Hypoaldosteronism; Mineralocort	1999
Role of cyclic nucleotides in the transport of water and electrolytes. Advances in cyclic nucleotide research, 1977, Volume: 8 Topics: Aldosterone; Animals; Biological Transport, Active; Body Water; Calcitonin; Cholera Toxin; Cyclic AM	1977
On the mechanisms of fasting natriuresis and of carbohydrate-induced sodium retention. Diabete & metabolisme, 1977, Volume: 3, Issue:2 Topics: Aldosterone; Blood Glucose; Dietary Carbohydrates; Electrolytes; Fasting; Glucagon; Humans; Hydroxyb	1977
Low renin hypertension: a current review of definitions and controversies. American heart journal, 1979, Volume: 98, Issue:5 Topics: Aging; Aldosterone; Antihypertensive Agents; Black People; Electrolytes; Female; Humans; Hypertensio	1979
Aldosterone-regulated ion transporters in the kidney. Klinische Wochenschrift, 1990, Nov-16, Volume: 68, Issue:22 Topics: Aldosterone; Animals; Bicarbonates; Biological Transport; Electrolytes; Hydrogen-Ion Concentration;	1990
Extrarenal receptor-effector-mechanisms for aldosterone: the sequence of effects on the cellular electrolyte transport in human lymphocytes and their implications for disorders of the water and electrolyte balances. Acta endocrinologica, 1990, Volume: 123, Issue:4 Topics: Aldosterone; Biological Transport; Electrolytes; Humans; Lymphocytes; Receptors, Glucocorticoid; Rec	1990
Primary hyperaldosteronism. The American journal of the medical sciences, 1990, Volume: 300, Issue:3 Topics: Aldosterone; Desoxycorticosterone; Electrolytes; Humans; Hyperaldosteronism; Hypertension; Kidney Tu	1990
Regulation of renal ion transport and cell growth by sodium. The American journal of physiology, 1989, Volume: 257, Issue:1 Pt 2 Topics: Aldosterone; Animals; Biological Transport; Cell Division; Electrolytes; Epithelium; Humans; Hyperpl	1989
Angiotensin-converting enzyme inhibitors in heart failure. The Medical clinics of North America, 1989, Volume: 73, Issue:2 Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Electrolytes; Heart Failure; Hemodynamics; Hu	1989
Influence of prolonged physical exercise on plasma volume, plasma proteins, electrolytes, and fluid-regulating hormones. International journal of sports medicine, 1989, Volume: 10, Issue:4 Topics: Adolescent; Adult; Aldosterone; Arginine Vasopressin; Blood Proteins; Body Fluids; Electrolytes; Exe	1989
Role of renin-angiotensin-aldosterone system in NaCl appetite of rats. The American journal of physiology, 1985, Volume: 248, Issue:1 Pt 2 Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Appetite Regulation; Captopril; Desoxycorticost	1985
[Renin-angiotensin-aldosterone system in blood pressure regulation disorders]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1968, Volume: 74 Topics: Adult; Aldosterone; Angiotensin II; Child; Electrolytes; Female; Humans; Hydrogen-Ion Concentration;	1968
[Regulation of aldosterone secretion]. Klinische Wochenschrift, 1971, Apr-01, Volume: 49, Issue:7 Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; E	1971
Adrenal mineralocorticoids causing hypertension. The American journal of medicine, 1972, Volume: 52, Issue:5 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Aldosterone; Corticosterone; Desoxyc	1972
Alterations in sweat gland function produced by pharmacological agents. Advances in biology of skin, 1972, Volume: 12 Topics: Acetazolamide; Adrenal Cortex Hormones; Aldosterone; Animals; Bicarbonates; Cats; Electrolytes; Huma	1972
Aldosterone, the adrenal cortex, and hypertension. Annual review of medicine, 1968, Volume: 19 Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Aldosterone; Animals; Bloo	1968
Commentary on incidence of primary aldosteronism: current estimations based on objective data. Archives of internal medicine, 1969, Volume: 123, Issue:2 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Blood Pressure; Desoxycorticosterone;	1969
[Refractory hepatic cirrosis and the ineffectiveness of diuretics in ascites and edema]. Naika. Internal medicine, 1969, Volume: 24, Issue:5 Topics: Aldosterone; Ascites; Blood Proteins; Capillary Permeability; Diuretics; Edema; Electrolytes; Humans	1969
The metabolic influence of progestins. Advances in metabolic disorders, 1971, Volume: 5 Topics: Aldosterone; Amino Acids; Anabolic Agents; Carbon Dioxide; Clinical Trials as Topic; Contraceptives,	1971
[Aldosterone and steroids in water and electrolyte metabolism]. Horumon to rinsho. Clinical endocrinology, 1971, Volume: 19, Issue:4 Topics: Adrenal Cortex Hormones; Aldosterone; Blood Pressure; Digestive System; Electrolytes; Humans; Kidney	1971

Article	Year
A prospective, randomized, double-blind, placebo-controlled pilot study of sacubitril/valsartan (Entresto) in dogs with cardiomegaly secondary to myxomatous mitral valve disease. Journal of veterinary internal medicine, 2018, Volume: 32, Issue:5 Topics: Aldosterone; Aminobutyrates; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pr	2018
Effects of a contraceptive containing drospirenone and ethinylestradiol on blood pressure, metabolic profile and neurohumoral axis in hypertensive women at reproductive age. European journal of obstetrics, gynecology, and reproductive biology, 2014, Volume: 182 Topics: Adult; Aldosterone; Androstenes; Antihypertensive Agents; Baroreflex; Blood Pressure; Body Mass Inde	2014
Aldosterone-Signaling Defect Exacerbates Sodium Wasting in Very Preterm Neonates: The Premaldo Study. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:11 Topics: Adolescent; Adult; Aging; Aldosterone; Birth Weight; Electrolytes; Female; Fetal Blood; Gestational	2015
Low-Sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans. Journal of human hypertension, 2009, Volume: 23, Issue:12 Topics: Adult; Aldosterone; Aorta; Blood Pressure; Cardiac Output; Diet, Sodium-Restricted; Elasticity; Elec	2009
CYP2C9 genotype modifies activity of the renin-angiotensin-aldosterone system in hypertensive men. Journal of hypertension, 2009, Volume: 27, Issue:10 Topics: Adult; Aldosterone; Amlodipine; Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Bisoprolol;	2009
Hyperhydration induced by glycerol ingestion: hormonal and renal responses. Canadian journal of physiology and pharmacology, 2002, Volume: 80, Issue:6 Topics: Adult; Aldosterone; Algorithms; Arginine Vasopressin; Atrial Natriuretic Factor; Body Weight; Electr	2002
Idiopathic primary hyperaldosteronism: normalization of plasma aldosterone after one month withdrawal of long-term therapy with aldosterone-receptor antagonist potassium canrenoate. Journal of endocrinological investigation, 2005, Volume: 28, Issue:3 Topics: Adult; Aldosterone; Blood Pressure; Canrenoic Acid; Electrolytes; Female; Follow-Up Studies; Humans;	2005
Effects of acute administration of zetidoline, a new antidopaminergic drug, on plasma prolactin and aldosterone levels in man. European journal of clinical pharmacology, 1984, Volume: 26, Issue:1 Topics: Adult; Aldosterone; Antipsychotic Agents; Blood Pressure; Dopamine Antagonists; Electrolytes; Female	1984
The therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism. Clinical and experimental hypertension. Part A, Theory and practice, 1983, Volume: 5, Issue:6 Topics: Adult; Aged; Aldosterone; Amiloride; Angiotensin-Converting Enzyme Inhibitors; Dipeptides; Diuretics	1983
Effects of prostaglandin synthesis inhibition on blood pressure and humoral factors in exercising, sodium-deplete normal man. Journal of hypertension, 1983, Volume: 1, Issue:2 Topics: Adult; Aldosterone; Angiotensin II; Blood Pressure; Catecholamines; Diet, Sodium-Restricted; Electro	1983
[Hypotensive properties of nisoldipine. Comparative study in essential, renal and renovascular hypertension]. Arzneimittel-Forschung, 1984, Volume: 34, Issue:5 Topics: Adult; Aged; Aldosterone; Calcium Channel Blockers; Electrolytes; Female; Heart Rate; Humans; Hydroc	1984
Response of renin, aldosterone and antidiuretic hormone to furosemide and furosemide-triamterene combination. International journal of clinical pharmacology, therapy, and toxicology, 1980, Volume: 18, Issue:9 Topics: Adult; Aldosterone; Drug Combinations; Electrolytes; Furosemide; Humans; Male; Random Allocation; Re	1980
Spironolactone in thiazide-induced hypokalaemia: variable response between patients. British journal of clinical pharmacology, 1981, Volume: 11, Issue:2 Topics: Adult; Aldosterone; Benzothiadiazines; Canrenone; Diuretics; Electrolytes; Female; Humans; Hypokalem	1981
Comparison of the oral angiotensin II receptor antagonist UP 269-6 or enalapril 20 mg on blood pressure and neurohormonal effects in salt-deplete man. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:6 Topics: Administration, Oral; Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angioten	1995
Haemodynamic and renal responses to oral losartan potassium during salt depletion or salt repletion in normal human volunteers. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:4 Topics: Adult; Aldosterone; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Creatinine; Double-	1995
Dose-ranging study of the angiotensin type I receptor antagonist losartan (DuP753/MK954), in salt-deplete normal man. Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:5 Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pres	1993
Renal response to candoxatrilat in patients with heart failure. Journal of the American College of Cardiology, 1995, Volume: 25, Issue:6 Topics: Aged; Aldosterone; Atrial Natriuretic Factor; Cross-Over Studies; Cyclic GMP; Cyclohexanecarboxylic	1995
Renal hemodynamics and sodium excretion after acute and chronic administration of cicletanine in normotensive and hypertensive subjects. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:2 Topics: Administration, Oral; Adult; Aldosterone; Analysis of Variance; Antihypertensive Agents; Atrial Natr	1995
Hemodynamic and biochemical effects of the AT1 receptor antagonist irbesartan in hypertension. Hypertension (Dallas, Tex. : 1979), 1995, Volume: 25, Issue:1 Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Body Weigh	1995
The influence of salt intake on plasma calcitonin gene-related peptide in subjects with mild essential hypertension. Journal of hypertension, 1994, Volume: 12, Issue:11 Topics: Adult; Aged; Aldosterone; Blood Pressure; Body Weight; Calcitonin Gene-Related Peptide; Cross-Over S	1994
Effect of atrial natriuretic hormone on hypertonic saline-induced suppression of the renin-aldosterone system. American journal of hypertension, 1994, Volume: 7, Issue:6 Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Diet, Sodium-Restricted;	1994
Exogenous aldosterone antagonizes distal tubular effects of calcium entry blocker felodipine. The American journal of physiology, 1994, Volume: 266, Issue:6 Pt 2 Topics: Adult; Aldosterone; Calcium Channel Blockers; Diuresis; Electrolytes; Felodipine; Hemodynamics; Huma	1994
Angiotensin II suppression is a major factor permitting excretion of an acute sodium load in humans. The American journal of physiology, 1994, Volume: 266, Issue:1 Pt 2 Topics: Adult; Aldosterone; Angiotensin II; Blood Pressure; Diuresis; Double-Blind Method; Electrolytes; Fem	1994
Salt-dependent renal effects of an angiotensin II antagonist in healthy subjects. Hypertension (Dallas, Tex. : 1979), 1993, Volume: 22, Issue:3 Topics: Adult; Aldosterone; Angiotensin II; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Electro	1993
Effect of plasma prolactin on sweat rate and sweat composition during exercise in men. The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 2 Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Bromocriptine; Electrolytes; Exercise; Humans; Male;	1993
Effect of fludrocortisone and spironolactone on sodium and potassium losses in secretory diarrhea. Digestive diseases and sciences, 1997, Volume: 42, Issue:1 Topics: Adult; Aldosterone; Body Weight; Cathartics; Diarrhea; Electrolytes; Feces; Female; Fludrocortisone;	1997
Dopamine natriuresis in salt-repleted, water-loaded humans: a dose-response study. British journal of clinical pharmacology, 1997, Volume: 43, Issue:5 Topics: Adult; Aldosterone; Body Water; Catecholamines; Dopamine; Dose-Response Relationship, Drug; Double-B	1997
Dietary sodium restriction impairs insulin sensitivity in noninsulin-dependent diabetes mellitus. The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:5 Topics: Aged; Aldosterone; Angiotensin II; Cross-Over Studies; Diabetes Mellitus, Type 2; Diet, Sodium-Restr	1998
Changes in blood pressure and in vasoactive and volume regulatory hormones during semistarvation in obese subjects. Metabolism: clinical and experimental, 1998, Volume: 47, Issue:5 Topics: Adolescent; Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Blood Urea Nitrogen; Body	1998
Hemodynamic, cardiac, and electrolyte effects of low-dose aerosolized terbutaline sulfate in asthmatic patients. Chest, 1998, Volume: 114, Issue:2 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Aerosols; Aldosterone; Asthma; Bicarbon	1998
Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide. Hepatology (Baltimore, Md.), 1999, Volume: 29, Issue:6 Topics: Aldosterone; Ascites; Blood Pressure; Diuresis; Electrolytes; Gastrointestinal Agents; Glomerular Fi	1999
NaHCO(3) and KHCO(3) ingestion rapidly increases renal electrolyte excretion in humans. Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 88, Issue:2 Topics: Acid-Base Equilibrium; Acids; Administration, Oral; Adult; Aldosterone; Alkalies; Bicarbonates; Calc	2000
Proximal sodium reabsorption: An independent determinant of blood pressure response to salt. Hypertension (Dallas, Tex. : 1979), 2000, Volume: 36, Issue:4 Topics: Adult; Aldosterone; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Electrolytes; Fem	2000
Interaction of rapid nongenomic cardiovascular aldosterone effects with the adrenergic system. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Aldosterone	2001
Adverse cardiac effects of salt with fludrocortisone in hypertension. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:3 Topics: Aldosterone; Anti-Inflammatory Agents; Echocardiography; Electrocardiography; Electrolytes; Female;	2001
Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Critical care medicine, 2001, Volume: 29, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin II; Atrial Natriuretic Factor;	2001
Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Critical care medicine, 2001, Volume: 29, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin II; Atrial Natriuretic Factor;	2001
Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Critical care medicine, 2001, Volume: 29, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin II; Atrial Natriuretic Factor;	2001
Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Critical care medicine, 2001, Volume: 29, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin II; Atrial Natriuretic Factor;	2001
Omapatrilat versus lisinopril: efficacy and neurohormonal profile in salt-sensitive hypertensive patients. Hypertension (Dallas, Tex. : 1979), 2001, Dec-01, Volume: 38, Issue:6 Topics: Adult; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood	2001
Defective regulation and action of atrial natriuretic peptide in type 2 diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2002, Volume: 34, Issue:5 Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Blood Glucose; Blood Volume; Body Mass Index; D	2002
The renin-aldosterone system in dihydralazine therapy during hypertensive pregnancy. International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:12 Topics: Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Dihydralazine; Electrolytes; Female; H	1978
Once-daily metoprolol in primary hypertension. Clinical pharmacology and therapeutics, 1979, Volume: 25, Issue:4 Topics: Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Drug Administration Schedule; Electrol	1979
[Correlation between plasma volume and plasma renin activity, aldosteronemia, blood electrolytes and arterial pressure in a group of randomized hypertensives]. Bollettino della Societa italiana di cardiologia, 1979, Volume: 24, Issue:5 Topics: Adolescent; Adult; Aldosterone; Blood Pressure; Electrolytes; Female; Humans; Hypertension; Male; Mi	1979
Renin-aldosterone system and urinary electrolytes after amiloride, hydrochlorothiazide and the combination. International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:11 Topics: Adolescent; Adult; Aldosterone; Amiloride; Drug Combinations; Electrolytes; Female; Humans; Hydrochl	1978
Blood pressure response to acute changes in dietary sodium in young Zimbabwean men. Journal of hypertension, 1992, Volume: 10, Issue:3 Topics: Adult; Aldosterone; Analysis of Variance; Angiotensin II; Atrial Natriuretic Factor; Blood Pressure;	1992
Long-term diuretic therapy: effects of dose reduction on antihypertensive efficacy and counterregulatory systems. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:3 Topics: Aldosterone; Benzothiadiazines; Blood Pressure; Body Weight; Diuretics; Dose-Response Relationship,	1992
Preferred salt levels and salt taste acuity in human subjects after ingestion of untasted salt. Appetite, 1992, Volume: 18, Issue:2 Topics: Adult; Aldosterone; Blood Pressure; Body Weight; Creatinine; Electrolytes; Female; Food Preferences;	1992
A study of the acute pharmacodynamic interaction of ramipril and felodipine in normotensive subjects. British journal of clinical pharmacology, 1991, Volume: 31, Issue:2 Topics: Adult; Aldosterone; Blood Pressure; Bridged Bicyclo Compounds; Double-Blind Method; Drug Interaction	1991
Atrial natriuretic factor during hypoxia and mild exercise. Aviation, space, and environmental medicine, 1991, Volume: 62, Issue:4 Topics: Adult; Aldosterone; Altitude Sickness; Atrial Natriuretic Factor; Blood Gas Analysis; Electrolytes;	1991
Atrial natriuretic factor inhibits metoclopramide stimulated aldosterone release in man. British journal of clinical pharmacology, 1991, Volume: 32, Issue:1 Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Dose-Response Relationship, Drug; Drug Interactions;	1991
Chronic effect of KCl on black-white differences in plasma renin activity, aldosterone, and urinary electrolytes. American journal of hypertension, 1991, Volume: 4, Issue:5 Pt 1 Topics: Adolescent; Adult; Aged; Aldosterone; Black People; Creatinine; Electrolytes; Humans; Male; Middle A	1991
Inhibition of endopeptidase EC 24.11 in humans. Renal and endocrine effects. Hypertension (Dallas, Tex. : 1979), 1990, Volume: 16, Issue:3 Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Electrolytes; Humans; Indans; Indenes; Kidney; Male;	1990
Novel multivalent effects of pyrazinoylguanidine in patients with azotemia. Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:5 Topics: Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Creatinine; Electrolytes; Female; Glom	1990
Natriuretic effect of acute nifedipine administration is not mediated by the renal kallikrein-kinin system. Journal of cardiovascular pharmacology, 1987, Volume: 9, Issue:5 Topics: Adult; Aldosterone; Blood Pressure; Electrolytes; Heart Rate; Humans; Kallikreins; Kidney; Kinins; M	1987
The renal and haemodynamic effects of a 10 h infusion of glutamyl-L-dopa in normal man. British journal of clinical pharmacology, 1989, Volume: 27, Issue:6 Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Dihydroxyphenylalanine;	1989
Hypertensive dysregulation and its modification by calcium channel blockade in nonoliguric renal failure. American journal of nephrology, 1989, Volume: 9, Issue:4 Topics: Adult; Aged; Aldosterone; Angiotensin II; Blood Pressure; Calcium Channel Blockers; Catecholamines;	1989
Corticosteroid-induced stimulation of atrial natriuretic peptide in man. Acta endocrinologica, 1988, Volume: 118, Issue:2 Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Clinical Trials as Topic; Electrolyte	1988
Effects of incremental infusions of atrial natriuretic factor on aldosterone, renin, and blood pressure in humans. Hypertension (Dallas, Tex. : 1979), 1988, Volume: 12, Issue:4 Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Dose-Response Relationship, Drug; Ele	1988
Beta-adrenoceptors and the regulation of blood pressure and plasma renin during exercise. Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 60, Issue:1 Topics: Adult; Aldosterone; Atenolol; Blood Pressure; Electrolytes; Heart Rate; Humans; Male; Physical Endur	1986
Effect of an opiate antagonist on the responses of circulating catecholamines and the renin-aldosterone system to acute sympathetic stimulation by hand-grip in man. Acta endocrinologica, 1986, Volume: 111, Issue:2 Topics: Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Electrolytes; Epi	1986
Effects of moderate low sodium/high potassium diet on essential hypertension: results of a comparative study. International journal of clinical pharmacology, therapy, and toxicology, 1988, Volume: 26, Issue:3 Topics: Adult; Aldosterone; Blood Pressure; Body Weight; Clinical Trials as Topic; Diet; Double-Blind Method	1988
Plasma renin activity does not predict the antihypertensive efficacy of chlorthalidone. European journal of clinical pharmacology, 1987, Volume: 33, Issue:3 Topics: Adult; Aldosterone; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Double-Blind Method; E	1987
Aldosterone and prolactin responsiveness after prolonged treatment of congestive heart failure with captopril. European journal of clinical pharmacology, 1985, Volume: 28, Issue:1 Topics: Adult; Aged; Aldosterone; Captopril; Dexamethasone; Electrolytes; Epinephrine; Female; Heart Failure	1985
The metabolic influence of progestins. Advances in metabolic disorders, 1971, Volume: 5 Topics: Aldosterone; Amino Acids; Anabolic Agents; Carbon Dioxide; Clinical Trials as Topic; Contraceptives,	1971

aldosterone and Electrolytes