aldosterone has been researched along with Cardiomyopathy, Dilated in 26 studies
Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The hemodynamic, clinical, and neurohumeral effects of a prolonged (6-days) intravenous enoximone-infusion therapy were evaluated in 12 patients suffering from severe cardiac failure due to dilated cardiomyopathy." | 7.68 | [Continuous enoximone infusion in patients with severe heart failure in dilated cardiomyopathy, hemodynamic, neurohumoral, chemical laboratory and clinical results]. ( Lissmann, H; Mitrovic, V; Neuzner, J; Pitschner, HF; Schlepper, M, 1991) |
| "Aldosterone escape was defined as plasma levels of aldosterone above the normal range in our laboratory (> 0." | 5.31 | Relation of aldosterone "escape" despite angiotensin-converting enzyme inhibitor administration to impaired exercise capacity in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Caruso, B; Cicoira, M; Franceschini, L; Golia, G; Rossi, A; Zanolla, L; Zardini, P; Zeni, P, 2002) |
| "Thus, in patients with dilated cardiomyopathy and mild cardiac dysfunction, plasma ANF levels are not increased by volume expansion as observed in N." | 5.28 | Failure of atrial natriuretic factor to increase with saline load in patients with dilated cardiomyopathy and mild heart failure. ( De Campora, P; De Luca, N; Enea, I; Lembo, G; Mele, AF; Ricciardelli, B; Romano, M; Rubattu, S; Tritto, C; Volpe, M, 1991) |
| "The hemodynamic, clinical, and neurohumeral effects of a prolonged (6-days) intravenous enoximone-infusion therapy were evaluated in 12 patients suffering from severe cardiac failure due to dilated cardiomyopathy." | 3.68 | [Continuous enoximone infusion in patients with severe heart failure in dilated cardiomyopathy, hemodynamic, neurohumoral, chemical laboratory and clinical results]. ( Lissmann, H; Mitrovic, V; Neuzner, J; Pitschner, HF; Schlepper, M, 1991) |
| "Treatment with prazosin for one month also reduced systemic vascular resistance by 8%, renal vascular resistance increased by 20%, and renal blood flow and the percentage of the cardiac output going to the kidney fell by 14% and 26%." | 2.66 | The renal response to neuroendocrine inhibition in chronic heart failure: double-blind comparison of captopril and prazosin. ( Bayliss, J; Canepa-Anson, R; Norell, M; Poole-Wilson, P; Sutton, G, 1986) |
| "We postulate that hyperreninemic-hyperaldosteronism followed by fluid retention caused a sudden severe increase in ventricular afterload and subsequent congestive heart failure in this patient." | 1.37 | Congestive heart failure as an initial manifestation of reninoma. ( Cho, MJ; Lee, HD; Park, JA; Sung, EY, 2011) |
| "In patients with dilated cardiomyopathy (DCM) abnormal myocardial blood flow (MBF) has been associated with coronary microvascular dysfunction." | 1.36 | Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy. ( Cabiati, M; Caselli, C; Del Ry, S; Giannessi, D; Iervasi, A; Maltinti, M; Mazzone, AM; Neglia, D; Prontera, C, 2010) |
| "The study was made in 45 patients with congestive heart failure treated in the Department of Cardiology." | 1.32 | [Cytokines and remodeling of the heart in patients with congestive heart failure]. ( Jołda-Mydłowska, B; Salomon, P, 2003) |
| "To evaluate the effect of dilated cardiomyopathy (DCM) on activity of the renin-angiotensin-aldosterone system (RAAS), the N-terminal fragment of proatrial natriuretic peptide (NT-proANP), and thyroid hormone concentrations in dogs." | 1.31 | Effects of dilated cardiomyopathy on the renin-angiotensin-aldosterone system, atrial natriuretic peptide activity, and thyroid hormone concentrations in dogs. ( Häggström, J; Hansson, K; Tidholm, A, 2001) |
| "Aldosterone escape was defined as plasma levels of aldosterone above the normal range in our laboratory (> 0." | 1.31 | Relation of aldosterone "escape" despite angiotensin-converting enzyme inhibitor administration to impaired exercise capacity in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Caruso, B; Cicoira, M; Franceschini, L; Golia, G; Rossi, A; Zanolla, L; Zardini, P; Zeni, P, 2002) |
| "Thus, in patients with dilated cardiomyopathy and mild cardiac dysfunction, plasma ANF levels are not increased by volume expansion as observed in N." | 1.28 | Failure of atrial natriuretic factor to increase with saline load in patients with dilated cardiomyopathy and mild heart failure. ( De Campora, P; De Luca, N; Enea, I; Lembo, G; Mele, AF; Ricciardelli, B; Romano, M; Rubattu, S; Tritto, C; Volpe, M, 1991) |
| "The study has shown that in congestive cardiomyopathy shifts in the renin-angiotensin-aldosterone system are of the same nature as in patients with congestive heart failure of another etiology." | 1.27 | [Plasma renin activity and aldosterone concentration of patients with congestive cardiomyopathy]. ( Botnar', VI; Popovich, MI; Zatushevskiĭ, IF, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.54) | 18.7374 |
| 1990's | 16 (61.54) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Del Ry, S | 1 |
| Giannessi, D | 1 |
| Maltinti, M | 1 |
| Cabiati, M | 1 |
| Prontera, C | 1 |
| Iervasi, A | 1 |
| Caselli, C | 1 |
| Mazzone, AM | 1 |
| Neglia, D | 1 |
| Cho, MJ | 1 |
| Sung, EY | 1 |
| Park, JA | 1 |
| Lee, HD | 1 |
| Jołda-Mydłowska, B | 1 |
| Salomon, P | 1 |
| Ishikawa, C | 1 |
| Tsutamoto, T | 1 |
| Wada, A | 1 |
| Fujii, M | 1 |
| Ohno, K | 1 |
| Sakai, H | 1 |
| Yamamoto, T | 1 |
| Horie, M | 1 |
| Iervasi, G | 2 |
| Clerico, A | 2 |
| Pilo, A | 2 |
| Berti, S | 2 |
| Vitek, F | 1 |
| Biagini, A | 2 |
| Bianchi, R | 2 |
| Donato, L | 2 |
| Mertes, PM | 1 |
| Levy, B | 1 |
| Dopff, C | 1 |
| Pinelli, G | 1 |
| Carteaux, JP | 1 |
| Burtin, P | 1 |
| Hottier, E | 1 |
| Clavey, M | 1 |
| Villemot, JP | 1 |
| Trikas, A | 1 |
| Triposkiadis, F | 1 |
| Pitsavos, C | 1 |
| Tentolouris, K | 1 |
| Kyriakidis, M | 1 |
| Gialafos, J | 1 |
| Toutouzas, P | 1 |
| Brilla, CG | 1 |
| Maisch, B | 1 |
| Rupp, H | 1 |
| Funck, R | 1 |
| Zhou, G | 1 |
| Weber, KT | 1 |
| Lage, SG | 1 |
| Kopel, L | 1 |
| Monachini, MC | 1 |
| Medeiros, CJ | 1 |
| Pileggi, F | 1 |
| Polak, JF | 1 |
| Creager, MA | 1 |
| Kittleson, MD | 1 |
| Johnson, LE | 1 |
| Pion, PD | 1 |
| Mekhamer, YE | 1 |
| Koch, J | 1 |
| Pedersen, HD | 1 |
| Jensen, AL | 1 |
| Flagstad, A | 1 |
| Poulsen, K | 1 |
| de Groote, P | 1 |
| Millaire, A | 1 |
| Racadot, A | 1 |
| Decoulx, E | 1 |
| Ducloux, G | 1 |
| Tidholm, A | 1 |
| Häggström, J | 1 |
| Hansson, K | 1 |
| Cicoira, M | 1 |
| Zanolla, L | 1 |
| Franceschini, L | 1 |
| Rossi, A | 1 |
| Golia, G | 1 |
| Zeni, P | 1 |
| Caruso, B | 1 |
| Zardini, P | 1 |
| Spinelli, L | 1 |
| Petretta, M | 1 |
| Vicario, ML | 1 |
| Schiavone, D | 1 |
| De Santis, V | 1 |
| Bonaduce, D | 1 |
| Condorelli, M | 2 |
| Cugini, P | 1 |
| Gasbarrone, L | 1 |
| Lucia, P | 1 |
| Cianetti, A | 1 |
| Canova, R | 1 |
| Di Palma, L | 1 |
| Sepe, FA | 1 |
| Pozzilli, P | 1 |
| Scibilia, G | 1 |
| Cioli, AR | 1 |
| Zirm, B | 1 |
| Zirm, A | 1 |
| Kargl, R | 1 |
| Hartter, E | 1 |
| Mrochek, AG | 1 |
| Sytyĭ, VP | 1 |
| Livshits, IB | 1 |
| Sherstiuk, GV | 1 |
| Alekseeva, DD | 1 |
| Ivanchikov, VI | 1 |
| Kripskaia, NE | 1 |
| Hensen, J | 1 |
| Levenson, B | 1 |
| Schröder, K | 1 |
| Jereczek, M | 1 |
| Spielberg, C | 1 |
| Schwenn, K | 1 |
| Gross, P | 1 |
| Neuzner, J | 1 |
| Mitrovic, V | 1 |
| Pitschner, HF | 1 |
| Lissmann, H | 1 |
| Schlepper, M | 1 |
| Volpe, M | 2 |
| Tritto, C | 2 |
| De Luca, N | 1 |
| Mele, AF | 2 |
| Lembo, G | 2 |
| Rubattu, S | 1 |
| Romano, M | 1 |
| De Campora, P | 1 |
| Enea, I | 1 |
| Ricciardelli, B | 2 |
| DeLuca, N | 1 |
| Marchegiano, R | 1 |
| Trimarco, B | 1 |
| Lawal, SO | 1 |
| Osotimehin, BO | 1 |
| Falase, AO | 1 |
| Bayliss, J | 1 |
| Canepa-Anson, R | 1 |
| Norell, M | 1 |
| Poole-Wilson, P | 1 |
| Sutton, G | 1 |
| Popovich, MI | 1 |
| Zatushevskiĭ, IF | 1 |
| Botnar', VI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exercise Intolerance in Elderly Diastolic Heart Failure[NCT00123955] | Phase 3 | 80 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Left ventricle measurements by MRI:~Mass/end diastolic volume ratio: g/ml" (NCT00123955)
Timeframe: Baseline, 9 month
| Intervention | g/ml (Mean) | |
|---|---|---|
| baseline | 9 month | |
| Placebo | 1.7 | 1.6 |
| Spironolactone | 1.8 | 1.7 |
Peak exercise VO2 (NCT00123955)
Timeframe: Baseline, 4 and 9 months
| Intervention | ml/kg/min (Mean) | ||
|---|---|---|---|
| Baseline | 4 months | 9 months | |
| Placebo | 13.3 | 13.5 | 13.9 |
| Spironolactone | 13.5 | 13.6 | 13.8 |
"Echocardiography Doppler measurement of left ventricular diastolic function:~Early mitral annulus velocity (lateral) (Ea; cm/s)" (NCT00123955)
Timeframe: Baseline, 4 month and 9 month
| Intervention | cm/s (Mean) | ||
|---|---|---|---|
| baseline | 4 month | 9 month | |
| Placebo | 6.8 | 6.8 | 6.6 |
| Spironolactone | 7.0 | 7.0 | 7.4 |
"The Minnesota Living with Heart Failure Questionnaire (MLHF) is a self-administered disease-specific questionnaire for patients with Heart Failure, comprising 21 items rated on six-point Likert scales, representing different degrees of impact of HF on HRQoL, from 0 (none) to 5 (very much). It provides a total score (range 0-105, from best to worst HRQoL), as well as scores for two dimensions, physical (8 items, range 0-40) and emotional (5 items, range 0-25). The other eight items (of the total of 21) are only considered for the calculation of the total score.~Scale of 0-105:The higher the score the worse the heart failure related Quality of Life." (NCT00123955)
Timeframe: Baseline, 4 and 9 months
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Baseline | 4 months | Final- 9 months | |
| Placebo | 28 | 29 | 25 |
| Spironolactone | 32 | 29 | 29 |
1 review available for aldosterone and Cardiomyopathy, Dilated
| Article | Year |
|---|---|
Pharmacological modulation of cardiac fibroblast function.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomyopathy, Dilated; Collagen; E | 1995 |
2 trials available for aldosterone and Cardiomyopathy, Dilated
| Article | Year |
|---|---|
Inhibition of aldosterone and endothelin-1 by carperitide was attenuated with more than 1 week of infusion in patients with congestive heart failure.
Topics: Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Cardiomyopathy, Dilated; Chronic Disease; Cy | 2005 |
The renal response to neuroendocrine inhibition in chronic heart failure: double-blind comparison of captopril and prazosin.
Topics: Aged; Aldosterone; Captopril; Cardiac Output; Cardiomyopathy, Dilated; Coronary Disease; Double-Blin | 1986 |
23 other studies available for aldosterone and Cardiomyopathy, Dilated
| Article | Year |
|---|---|
Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy.
Topics: Aldosterone; Biomarkers; Cardiomyopathy, Dilated; Coronary Circulation; Female; Humans; Inflammation | 2010 |
Congestive heart failure as an initial manifestation of reninoma.
Topics: Adolescent; Aldosterone; Cardiomyopathy, Dilated; Female; Heart Failure; Humans; Hyperaldosteronism; | 2011 |
[Cytokines and remodeling of the heart in patients with congestive heart failure].
Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Biomarkers; Cardiomyopathy, Dilated; Catecholam | 2003 |
Kinetic study of atrial natriuretic peptide in patients with idiopathic dilated cardiomyopathy: evidence for resistance to biologic effects of the hormone even in patients with mild myocardial involvement.
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Cardiomyopathies; Cardiomyopathy, Dilated; Chromatogr | 1994 |
Right ventricular function following heart transplantation in relation to donor and recipient hemodynamic status and hormonal changes (vasopressin, renin, angiotensin II, aldosterone).
Topics: Adult; Aldosterone; Angiotensin II; Cardiomyopathies; Cardiomyopathy, Dilated; Heart Transplantation | 1995 |
Relation of left atrial volume and systolic function to the hormonal response in idiopathic dilated cardiomyopathy.
Topics: Adult; Aldosterone; Atrial Function, Left; Atrial Natriuretic Factor; Cardiac Volume; Cardiomyopathy | 1994 |
Altered tissue degradation and distribution of atrial natriuretic peptide in patients with idiopathic dilated cardiomyopathy and its relationship with clinical severity of the disease and sodium handling.
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Cardiomyopathy, Dilated; Chromatography, High Pressur | 1995 |
Carotid arterial compliance in patients with congestive heart failure secondary to idiopathic dilated cardiomyopathy.
Topics: Adult; Aged; Aldosterone; Cardiomyopathy, Dilated; Carotid Artery, Common; Compliance; Female; Heart | 1994 |
The acute haemodynamic effects of captopril in dogs with heart failure.
Topics: Administration, Oral; Aldosterone; Animals; Blood Pressure; Captopril; Cardiac Output; Cardiac Outpu | 1993 |
Activation of the renin-angiotensin system in dogs with asymptomatic and symptomatic dilated cardiomyopathy.
Topics: Aldosterone; Animals; Cardiomyopathy, Dilated; Dog Diseases; Dogs; Female; Heart Failure; Male; Refe | 1995 |
Plasma levels of endothelin-1 at rest and after exercise in patients with moderate congestive heart failure.
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Cardiomyopathy, Dilated; Disease Progression; Endothe | 1995 |
Effects of dilated cardiomyopathy on the renin-angiotensin-aldosterone system, atrial natriuretic peptide activity, and thyroid hormone concentrations in dogs.
Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Cardiomyopathy, Dilated; Creatinine; Dog Diseases; | 2001 |
Relation of aldosterone "escape" despite angiotensin-converting enzyme inhibitor administration to impaired exercise capacity in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
Topics: Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Cardiomyopathy, Dilated; Chronic Diseas | 2002 |
Losartan treatment and left ventricular filling during volume loading in patients with dilated cardiomyopathy.
Topics: Adult; Aldosterone; Analysis of Variance; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Flo | 2002 |
[The circadian rhythm of plasma vasoactive intestinal peptide, atrial natriuretic peptide, renin activity, aldosterone and cortisol in heart transplantation. The effects of immunosuppressive therapy].
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Cardiomyopathy, Dilated; Circadian Rhythm; Female; He | 1992 |
[Effects of treatment of arrhythmias requiring therapy in dilated cardiomyopathy with amiodarone on alpha human atrial natriuretic peptide].
Topics: Aged; Aldosterone; Amiodarone; Arginine Vasopressin; Arrhythmias, Cardiac; Atrial Natriuretic Factor | 1992 |
[Changes in the levels of atrial natriuretic factor, aldosterone, cyclic nucleotides and beta 2-microglobulin in patients with myocardial infarction after ultrasonic therapy].
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; beta 2-Microglobulin; Cardiomyopathy, Dilated; Cyclic | 1991 |
[Plasma endothelin is increased in heart failure--no effect of a short infusion of atrial natriuretic factor].
Topics: Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Cardiomyopathy, Dilated; Cyclic GMP; Endothe | 1991 |
[Continuous enoximone infusion in patients with severe heart failure in dilated cardiomyopathy, hemodynamic, neurohumoral, chemical laboratory and clinical results].
Topics: Aldosterone; Atrial Natriuretic Factor; Cardiomyopathy, Dilated; Cardiotonic Agents; Enoximone; Epin | 1991 |
Failure of atrial natriuretic factor to increase with saline load in patients with dilated cardiomyopathy and mild heart failure.
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Cardiomyopathy, Dilated; Female; Heart Failure; Hemat | 1991 |
[The early hemodynamic and hormonal changes in patients with left ventricular dysfunction].
Topics: Aldosterone; Atrial Natriuretic Factor; Cardiomyopathy, Dilated; Heart Failure; Hemodynamics; Humans | 1991 |
Mild hypertension in patients with suspected dilated cardiomyopathy: cause or consequence?
Topics: Adult; Aged; Aldosterone; Blood Pressure; Cardiomyopathy, Dilated; Electrolytes; Female; Heart Rate; | 1988 |
[Plasma renin activity and aldosterone concentration of patients with congestive cardiomyopathy].
Topics: Adult; Aldosterone; Cardiomyopathy, Dilated; Heart Failure; Humans; Renin | 1986 |