Page last updated: 2024-11-07

aldosterone and Apoplexy

aldosterone has been researched along with Apoplexy in 43 studies

Research Excerpts

ExcerptRelevanceReference
"To address this question, we examined data from the dal-OUTCOMES trial that compared the cholesteryl ester transfer protein inhibitor dalcetrapib with placebo, beginning 4 to 12 weeks after an index acute coronary syndrome."7.85Aldosterone Does Not Predict Cardiovascular Events Following Acute Coronary Syndrome in Patients Initially Without Heart Failure. ( Ballantyne, CM; Barter, PJ; Gunzburger, E; Kallend, D; Kittelson, J; Leiter, LA; Leitersdorf, E; McMurray, JJ; Nicholls, SJ; Olsson, AG; Pitts, R; Schwartz, GG; Shah, PK; Tardif, JC, 2017)
" The antistroke effects of captopril treatment occurred without an antihypertensive effect, weren't altered by enhancing hypertension during treatment (with dexamethasone), and couldn't be duplicated by antihypertensive treatment with hydralazine."7.70Effect of poststroke captopril treatment on mortality associated with hemorrhagic stroke in stroke-prone rats. ( King, SR; Smeda, J; Vasdev, S, 1999)
"Allisartan isoproxil (ALL) is a new angiotensin II receptor blocker and a new antihypertensive drug discovered and developed in China."5.62Allisartan isoproxil reduces mortality of stroke-prone rats and protects against cerebrovascular, cardiac, and aortic damage. ( Cheng, MH; Fu, FH; Ling, QS; Liu, AJ; Liu, JG; Miao, CY; Tian, JS; Zhang, SL, 2021)
"Prehypertension has been associated with adverse cerebrovascular events and brain damage."5.40Long-term prehypertension treatment with losartan effectively prevents brain damage and stroke in stroke-prone spontaneously hypertensive rats. ( He, DH; Lin, JX; Lin, LM; Ning, RB; Wang, HJ; Xu, CS; Zhang, LM, 2014)
"Aldosterone is a risk factor for stroke, and the literature suggests it may play a role in increasing the expression of the receptor for EGF (EGFR)."5.31Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats. ( Dorrance, AM; Grekin, R; Osborn, HL; Webb, RC, 2001)
"To address this question, we examined data from the dal-OUTCOMES trial that compared the cholesteryl ester transfer protein inhibitor dalcetrapib with placebo, beginning 4 to 12 weeks after an index acute coronary syndrome."3.85Aldosterone Does Not Predict Cardiovascular Events Following Acute Coronary Syndrome in Patients Initially Without Heart Failure. ( Ballantyne, CM; Barter, PJ; Gunzburger, E; Kallend, D; Kittelson, J; Leiter, LA; Leitersdorf, E; McMurray, JJ; Nicholls, SJ; Olsson, AG; Pitts, R; Schwartz, GG; Shah, PK; Tardif, JC, 2017)
"Angiotensin II type 1 receptor blockade has neuroprotective effects in animal stroke models, but no effects in clinical stroke trials."3.81RAAS and stress markers in acute ischemic stroke: preliminary findings. ( Back, C; Edvinsson, L; Iversen, HK; Jensen, LT; Larsen, VA; Skovgaard, K; Thiesen, KL, 2015)
" The antistroke effects of captopril treatment occurred without an antihypertensive effect, weren't altered by enhancing hypertension during treatment (with dexamethasone), and couldn't be duplicated by antihypertensive treatment with hydralazine."3.70Effect of poststroke captopril treatment on mortality associated with hemorrhagic stroke in stroke-prone rats. ( King, SR; Smeda, J; Vasdev, S, 1999)
"Early detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development."2.87Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib. ( DeLisle, RK; Ganz, P; Hyde, C; Malarstig, A; Murthy, AC; Ostroff, R; Segal, MR; Weiss, SJ; Williams, SA, 2018)
"Mycophenolic acid was detected in all cats."2.61 ( Abrams, G; Adolfsson, E; Agarwal, PK; Akkan, AG; Al Alhareth, NS; Alves, VGL; Armentano, R; Bahroos, E; Baig, M; Baldridge, KK; Barman, S; Bartolucci, C; Basit, A; Bertoli, SV; Bian, L; Bigatti, G; Bobenko, AI; Boix, PP; Bokulic, T; Bolink, HJ; Borowiec, J; Bulski, W; Burciaga, J; Butt, NS; Cai, AL; Campos, AM; Cao, G; Cao, Y; Čapo, I; Caruso, ML; Chao, CT; Cheatum, CM; Chelminski, K; Chen, AJW; Chen, C; Chen, CH; Chen, D; Chen, G; Chen, H; Chen, LH; Chen, R; Chen, RX; Chen, X; Cherdtrakulkiat, R; Chirvony, VS; Cho, JG; Chu, K; Ciurlino, D; Coletta, S; Contaldo, G; Crispi, F; Cui, JF; D'Esposito, M; de Biase, S; Demir, B; Deng, W; Deng, Z; Di Pinto, F; Domenech-Ximenos, B; Dong, G; Drácz, L; Du, XJ; Duan, LJ; Duan, Y; Ekendahl, D; Fan, W; Fang, L; Feng, C; Followill, DS; Foreman, SC; Fortunato, G; Frew, R; Fu, M; Gaál, V; Ganzevoort, W; Gao, DM; Gao, X; Gao, ZW; Garcia-Alvarez, A; Garza, MS; Gauthier, L; Gazzaz, ZJ; Ge, RS; Geng, Y; Genovesi, S; Geoffroy, V; Georg, D; Gigli, GL; Gong, J; Gong, Q; Groeneveld, J; Guerra, V; Guo, Q; Guo, X; Güttinger, R; Guyo, U; Haldar, J; Han, DS; Han, S; Hao, W; Hayman, A; He, D; Heidari, A; Heller, S; Ho, CT; Ho, SL; Hong, SN; Hou, YJ; Hu, D; Hu, X; Hu, ZY; Huang, JW; Huang, KC; Huang, Q; Huang, T; Hwang, JK; Izewska, J; Jablonski, CL; Jameel, T; Jeong, HK; Ji, J; Jia, Z; Jiang, W; Jiang, Y; Kalumpha, M; Kang, JH; Kazantsev, P; Kazemier, BM; Kebede, B; Khan, SA; Kiss, J; Kohen, A; Kolbenheyer, E; Konai, MM; Koniarova, I; Kornblith, E; Krawetz, RJ; Kreouzis, T; Kry, SF; Laepple, T; Lalošević, D; Lan, Y; Lawung, R; Lechner, W; Lee, KH; Lee, YH; Leonard, C; Li, C; Li, CF; Li, CM; Li, F; Li, J; Li, L; Li, S; Li, X; Li, Y; Li, YB; Li, Z; Liang, C; Lin, J; Lin, XH; Ling, M; Link, TM; Liu, HH; Liu, J; Liu, M; Liu, W; Liu, YP; Lou, H; Lu, G; Lu, M; Lun, SM; Ma, Z; Mackensen, A; Majumdar, S; Martineau, C; Martínez-Pastor, JP; McQuaid, JR; Mehrabian, H; Meng, Y; Miao, T; Miljković, D; Mo, J; Mohamed, HSH; Mohtadi, M; Mol, BWJ; Moosavi, L; Mosdósi, B; Nabu, S; Nava, E; Ni, L; Novakovic-Agopian, T; Nyamunda, BC; Nyul, Z; Önal, B; Özen, D; Özyazgan, S; Pajkrt, E; Palazon, F; Park, HW; Patai, Á; Patai, ÁV; Patzke, GR; Payette, G; Pedoia, V; Peelen, MJCS; Pellitteri, G; Peng, J; Perea, RJ; Pérez-Del-Rey, D; Popović, DJ; Popović, JK; Popović, KJ; Posecion, L; Povall, J; Prachayasittikul, S; Prachayasittikul, V; Prat-González, S; Qi, B; Qu, B; Rakshit, S; Ravelli, ACJ; Ren, ZG; Rivera, SM; Salo, P; Samaddar, S; Samper, JLA; Samy El Gendy, NM; Schmitt, N; Sekerbayev, KS; Sepúlveda-Martínez, Á; Sessolo, M; Severi, S; Sha, Y; Shen, FF; Shen, X; Shen, Y; Singh, P; Sinthupoom, N; Siri, S; Sitges, M; Slovak, JE; Solymosi, N; Song, H; Song, J; Song, M; Spingler, B; Stewart, I; Su, BL; Su, JF; Suming, L; Sun, JX; Tantimavanich, S; Tashkandi, JM; Taurbayev, TI; Tedgren, AC; Tenhunen, M; Thwaites, DI; Tibrewala, R; Tomsejm, M; Triana, CA; Vakira, FM; Valdez, M; Valente, M; Valentini, AM; Van de Winckel, A; van der Lee, R; Varga, F; Varga, M; Villarino, NF; Villemur, R; Vinatha, SP; Vincenti, A; Voskamp, BJ; Wang, B; Wang, C; Wang, H; Wang, HT; Wang, J; Wang, M; Wang, N; Wang, NC; Wang, Q; Wang, S; Wang, X; Wang, Y; Wang, Z; Wen, N; Wesolowska, P; Willis, M; Wu, C; Wu, D; Wu, L; Wu, X; Wu, Z; Xia, JM; Xia, X; Xia, Y; Xiao, J; Xiao, Y; Xie, CL; Xie, LM; Xie, S; Xing, Z; Xu, C; Xu, J; Yan, D; Yan, K; Yang, S; Yang, X; Yang, XW; Ye, M; Yin, Z; Yoon, N; Yoon, Y; Yu, H; Yu, K; Yu, ZY; Zhang, B; Zhang, GY; Zhang, H; Zhang, J; Zhang, M; Zhang, Q; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhang, YW; Zhang, Z; Zhao, D; Zhao, F; Zhao, P; Zhao, W; Zhao, Z; Zheng, C; Zhi, D; Zhou, C; Zhou, FY; Zhu, D; Zhu, J; Zhu, Q; Zinyama, NP; Zou, M; Zou, Z, 2019)
"Aldosterone has also been demonstrated to be a major factor in target organ damage independent of its effects on blood pressure."2.44Aldosterone as an independent factor in cerebrovascular damage. ( Bertello, C; Caserta, M; Giraudo, G; Morello, F; Mulatero, P; Schiavone, D; Veglio, F; Verhovez, A, 2008)
"Stroke is one of the leading causes of death in the Western world, and MR (mineralocorticoid receptor) antagonism is a potential preventative therapy for patients at risk of both ischaemic and haemorrhagic strokes."2.44Is the mineralocorticoid receptor a potential target for stroke prevention? ( Dorrance, AM; Osmond, JM; Rigsby, CS, 2008)
"Stroke is a leading cause of disability in the Western world, yet the choices for therapeutic intervention are few."2.43Aldosterone: good guy or bad guy in cerebrovascular disease? ( Cannady, WE; Dorrance, AM; Rigsby, CS, 2005)
"Primary aldosteronism (PA) is the most common cause of secondary hypertension, and patients are at an increased risk of atrial fibrillation (AF) and stroke."1.72Primary Aldosteronism More Prevalent in Patients With Cardioembolic Stroke and Atrial Fibrillation. ( Aw, TC; Chai, SC; Fones, S; Foo, RSY; Lai, J; Mamauag, MJB; Nguyen, V; Ong, L; Puar, TH; Saffari, SE; Tu, TM; Zhang, M, 2022)
"Allisartan isoproxil (ALL) is a new angiotensin II receptor blocker and a new antihypertensive drug discovered and developed in China."1.62Allisartan isoproxil reduces mortality of stroke-prone rats and protects against cerebrovascular, cardiac, and aortic damage. ( Cheng, MH; Fu, FH; Ling, QS; Liu, AJ; Liu, JG; Miao, CY; Tian, JS; Zhang, SL, 2021)
"Primary aldosteronism (PA) is notably an independent risk factor for cerebral vascular disease but currently with limited knowledge among young adults."1.56Primary aldosteronism in young adults with acute stroke: Prevalence and clinical characteristics. ( Chen, H; Cheng, Q; Du, Z; He, W; Hu, J; Li, Q; Luo, T; Ma, L; Mei, M; Song, Y; Tang, Z; Wang, Z; Yang, S, 2020)
"Stroke is a severe and frequent complication of Fabry disease (FD), affecting both males and females."1.56Fabry disease patients have an increased risk of stroke in the COVID-19 ERA. A hypothesis. ( Bonardo, P; Reisin, RC; Rozenfeld, P, 2020)
"Hypertension is the prime risk factor for stroke, and primary aldosteronism (PA) is the most common cause of secondary hypertension."1.43Primary aldosteronism in patients with acute stroke: prevalence and diagnosis during initial hospitalization. ( Joki, H; Kamide, T; Kawabata, Y; Kitamura, Y; Minami, T; Miyaji, Y; Mori, K; Nakaguchi, H; Nomura, M; Sasaki, M; Seki, S; Shima, H; Tamase, A; Tanaka, F; Tsunoda, T; Yamada, M, 2016)
"Prehypertension has been associated with adverse cerebrovascular events and brain damage."1.40Long-term prehypertension treatment with losartan effectively prevents brain damage and stroke in stroke-prone spontaneously hypertensive rats. ( He, DH; Lin, JX; Lin, LM; Ning, RB; Wang, HJ; Xu, CS; Zhang, LM, 2014)
"Primary aldosteronism (PA) is sometimes associated with the autonomous secretion of cortisol."1.37Cardiovascular complications of patients with aldosteronism associated with autonomous cortisol secretion. ( Hashimoto, K; Monden, T; Mori, M; Nakajima, Y; Okada, S; Ozawa, A; Satoh, T; Shibusawa, N; Taguchi, R; Yamada, M, 2011)
"Aldosterone is a risk factor for stroke, and the literature suggests it may play a role in increasing the expression of the receptor for EGF (EGFR)."1.31Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats. ( Dorrance, AM; Grekin, R; Osborn, HL; Webb, RC, 2001)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.33)18.2507
2000's10 (23.26)29.6817
2010's23 (53.49)24.3611
2020's9 (20.93)2.80

Authors

AuthorsStudies
Parksook, WW1
Williams, GH1
Nguyen, V1
Tu, TM1
Mamauag, MJB1
Lai, J1
Saffari, SE1
Aw, TC1
Ong, L1
Foo, RSY1
Chai, SC1
Fones, S1
Zhang, M2
Puar, TH1
Sarfo, FS1
Ovbiagele, B1
Meng, Y2
Chen, K1
Xie, A1
Liu, Y1
Huang, J1
De Silva, TM1
Faraci, FM1
Bobenko, AI1
Heller, S1
Schmitt, N1
Cherdtrakulkiat, R1
Lawung, R1
Nabu, S1
Tantimavanich, S1
Sinthupoom, N1
Prachayasittikul, S1
Prachayasittikul, V1
Zhang, B1
Wu, C1
Zhang, Z3
Yan, K1
Li, C2
Li, Y4
Li, L3
Zheng, C1
Xiao, Y1
He, D1
Zhao, F1
Su, JF1
Lun, SM1
Hou, YJ1
Duan, LJ1
Wang, NC1
Shen, FF1
Zhang, YW1
Gao, ZW1
Li, J5
Du, XJ1
Zhou, FY1
Yin, Z1
Zhu, J2
Yan, D1
Lou, H1
Yu, H1
Feng, C1
Wang, Z2
Wang, Y4
Hu, X1
Li, Z2
Shen, Y1
Hu, D1
Chen, H2
Wu, X1
Duan, Y1
Zhi, D1
Zou, M2
Zhao, Z1
Zhang, X2
Yang, X2
Zhang, J2
Wang, H1
Popović, KJ1
Popović, DJ1
Miljković, D1
Lalošević, D1
Čapo, I1
Popović, JK1
Liu, M1
Song, H2
Xing, Z1
Lu, G1
Chen, D1
Valentini, AM1
Di Pinto, F1
Coletta, S1
Guerra, V1
Armentano, R1
Caruso, ML1
Gong, J1
Wang, N2
Bian, L1
Wang, M1
Ye, M1
Wen, N1
Fu, M1
Fan, W1
Dong, G1
Lin, XH1
Liu, HH1
Gao, DM1
Cui, JF1
Ren, ZG1
Chen, RX1
Önal, B1
Özen, D1
Demir, B1
Akkan, AG1
Özyazgan, S1
Payette, G1
Geoffroy, V1
Martineau, C1
Villemur, R1
Jameel, T1
Baig, M1
Gazzaz, ZJ1
Tashkandi, JM1
Al Alhareth, NS1
Khan, SA1
Butt, NS1
Wang, J2
Geng, Y1
Zhang, Y3
Wang, X2
Liu, J2
Basit, A1
Miao, T1
Liu, W1
Jiang, W1
Yu, ZY1
Wu, L2
Qu, B1
Sun, JX1
Cai, AL1
Xie, LM1
Groeneveld, J1
Ho, SL1
Mackensen, A1
Mohtadi, M1
Laepple, T1
Genovesi, S1
Nava, E1
Bartolucci, C1
Severi, S1
Vincenti, A1
Contaldo, G1
Bigatti, G1
Ciurlino, D1
Bertoli, SV1
Slovak, JE1
Hwang, JK1
Rivera, SM1
Villarino, NF1
Li, S1
Cao, G1
Ling, M1
Ji, J1
Zhao, D1
Sha, Y1
Gao, X1
Liang, C2
Guo, Q1
Zhou, C1
Ma, Z1
Xu, J1
Wang, C1
Zhao, W1
Xia, X1
Jiang, Y1
Peng, J1
Jia, Z1
Li, F1
Chen, X2
Mo, J1
Zhang, S3
Li, X1
Huang, T1
Zhu, Q1
Wang, S1
Ge, RS1
Fortunato, G1
Lin, J2
Agarwal, PK1
Kohen, A1
Singh, P1
Cheatum, CM1
Zhu, D1
Hayman, A1
Kebede, B1
Stewart, I1
Chen, G1
Frew, R1
Guo, X1
Gong, Q1
Borowiec, J1
Han, S1
Willis, M1
Kreouzis, T1
Yu, K1
Chirvony, VS1
Sekerbayev, KS1
Pérez-Del-Rey, D1
Martínez-Pastor, JP1
Palazon, F1
Boix, PP1
Taurbayev, TI1
Sessolo, M1
Bolink, HJ1
Lu, M1
Lan, Y1
Xiao, J1
Song, M1
Chen, C1
Huang, Q1
Cao, Y1
Ho, CT1
Qi, B1
Wang, Q1
Zhang, W1
Fang, L1
Xie, CL1
Chen, R1
Yang, S2
Xia, JM1
Zhang, GY1
Chen, CH1
Yang, XW1
Domenech-Ximenos, B1
Garza, MS1
Prat-González, S1
Sepúlveda-Martínez, Á1
Crispi, F1
Perea, RJ1
Garcia-Alvarez, A1
Sitges, M1
Kalumpha, M1
Guyo, U1
Zinyama, NP1
Vakira, FM1
Nyamunda, BC1
Varga, M1
Drácz, L1
Kolbenheyer, E1
Varga, F1
Patai, ÁV1
Solymosi, N1
Patai, Á1
Kiss, J1
Gaál, V1
Nyul, Z1
Mosdósi, B1
Valdez, M1
Moosavi, L1
Heidari, A1
Novakovic-Agopian, T1
Kornblith, E1
Abrams, G1
McQuaid, JR1
Posecion, L1
Burciaga, J1
D'Esposito, M1
Chen, AJW1
Samy El Gendy, NM1
Wesolowska, P1
Georg, D1
Lechner, W1
Kazantsev, P1
Bokulic, T1
Tedgren, AC1
Adolfsson, E1
Campos, AM1
Alves, VGL1
Suming, L1
Hao, W1
Ekendahl, D1
Koniarova, I1
Bulski, W1
Chelminski, K1
Samper, JLA1
Vinatha, SP1
Rakshit, S1
Siri, S1
Tomsejm, M1
Tenhunen, M1
Povall, J1
Kry, SF1
Followill, DS1
Thwaites, DI1
Izewska, J1
Kang, JH1
Yoon, Y1
Song, J1
Van de Winckel, A1
Gauthier, L1
Chao, CT1
Lee, YH1
Li, CM1
Han, DS1
Huang, JW1
Huang, KC1
Ni, L1
Güttinger, R1
Triana, CA1
Spingler, B1
Baldridge, KK1
Patzke, GR1
Shen, X1
Wang, B1
Xie, S1
Deng, W1
Wu, D1
Zhang, Q1
Voskamp, BJ1
Peelen, MJCS1
Ravelli, ACJ1
van der Lee, R1
Mol, BWJ1
Pajkrt, E1
Ganzevoort, W1
Kazemier, BM1
Tibrewala, R1
Bahroos, E1
Mehrabian, H1
Foreman, SC1
Link, TM1
Pedoia, V1
Majumdar, S1
Jablonski, CL1
Leonard, C1
Salo, P1
Krawetz, RJ1
Yoon, N1
Hong, SN1
Cho, JG1
Jeong, HK1
Lee, KH1
Park, HW1
Barman, S1
Konai, MM1
Samaddar, S1
Haldar, J1
Mohamed, HSH1
Li, CF1
Hu, ZY1
Deng, Z1
Chen, LH1
Su, BL1
Chu, K1
Liu, YP1
Li, YB1
Zhang, H1
Xu, C1
Zou, Z1
Wu, Z1
Xia, Y1
Zhao, P1
Wang, HT1
de Biase, S1
Pellitteri, G1
Gigli, GL1
Valente, M1
Tang, Z1
He, W1
Ma, L1
Song, Y1
Mei, M1
Luo, T1
Du, Z1
Hu, J1
Cheng, Q1
Li, Q1
Wang, L1
Liu, D1
Yuan, K1
Zhu, G1
Qi, X1
Reisin, RC1
Rozenfeld, P1
Bonardo, P1
Ling, QS1
Zhang, SL1
Tian, JS1
Cheng, MH1
Liu, AJ1
Fu, FH1
Liu, JG1
Miao, CY1
Joseph, JJ1
Echouffo-Tcheugui, JB1
Kalyani, RR1
Yeh, HC1
Bertoni, AG1
Effoe, VS1
Casanova, R1
Sims, M1
Wu, WC1
Wand, GS1
Correa, A2
Golden, SH1
Williams, SA1
Murthy, AC1
DeLisle, RK1
Hyde, C1
Malarstig, A1
Ostroff, R1
Weiss, SJ1
Segal, MR1
Ganz, P1
Hillaert, MA2
den Ruijter, HM1
Hoefer, IE1
Lentjes, EG1
de Borst, GJ1
de Vries, JPM1
Doevendans, PA2
Pasterkamp, G1
Timmers, L1
Cannone, V1
Buglioni, A1
Sangaralingham, SJ1
Scott, C1
Bailey, KR1
Rodeheffer, R1
Redfield, MM1
Sarzani, R1
Burnett, JC1
Chen, L1
Zhang, P1
Shen, L1
Huang, S1
Zhang, C1
Deng, B1
Lambers Heerspink, HJ1
He, DH1
Zhang, LM1
Lin, LM1
Ning, RB1
Wang, HJ1
Xu, CS1
Lin, JX1
Sampson, AK1
Mohammed, D1
Beattie, W1
Graham, D1
Kenyon, CJ1
Al-Dujaili, EA1
Guryev, V1
Mcbride, MW1
Dominiczak, AF1
Back, C1
Thiesen, KL1
Skovgaard, K1
Edvinsson, L1
Jensen, LT1
Larsen, VA1
Iversen, HK1
Murakami, N1
Yoshida, N1
Hamano, K1
Suzuki, H1
Miyakawa, M1
Takeshita, A1
Takeuchi, Y1
Wang, W1
Shen, G1
Shahar, E1
Bidulescu, A1
Kimberly, WT1
Sheth, KN1
Campbell, BW1
Horbal, S1
Griswold, ME1
Miyaji, Y1
Kawabata, Y1
Joki, H1
Seki, S1
Mori, K1
Kamide, T1
Tamase, A1
Shima, H1
Nomura, M1
Kitamura, Y1
Nakaguchi, H1
Minami, T1
Tsunoda, T1
Sasaki, M1
Yamada, M2
Tanaka, F1
Jones, ES1
Spence, JD2
Mcintyre, AD1
Nondi, J1
Gogo, K1
Akintunde, A1
Hackam, DG1
Rayner, BL1
Pitts, R1
Gunzburger, E1
Ballantyne, CM1
Barter, PJ1
Kallend, D1
Leiter, LA1
Leitersdorf, E1
Nicholls, SJ1
Shah, PK1
Tardif, JC1
Olsson, AG1
McMurray, JJ1
Kittelson, J1
Schwartz, GG1
Mulatero, P1
Caserta, M1
Bertello, C1
Schiavone, D1
Verhovez, A1
Giraudo, G1
Morello, F1
Veglio, F1
Vyssoulis, GP1
Karpanou, EA1
Tzamou, VE1
Kyvelou, SM1
Michaelidis, AP1
Gialernios, TP1
Cokkinos, DV1
Stefanadis, CI1
Nakajima, Y1
Taguchi, R1
Satoh, T1
Hashimoto, K1
Ozawa, A1
Shibusawa, N1
Okada, S1
Monden, T1
Mori, M1
Mangoni, AA1
Knights, KM1
Ivanes, F1
Susen, S1
Mouquet, F1
Pigny, P1
Cuilleret, F1
Sautière, K1
Collet, JP1
Beygui, F1
Hennache, B1
Ennezat, PV1
Juthier, F1
Richard, F1
Dallongeville, J1
Jude, B1
Bertrand, M1
Montalescot, G1
Van Belle, E1
Nakagaki, T1
Hirooka, Y1
Matsukawa, R1
Nishihara, M1
Nakano, M1
Ito, K1
Hoka, S1
Sunagawa, K1
Satoh, M1
Kikuya, M1
Ohkubo, T1
Mori, T1
Metoki, H1
Hara, A1
Utsugi, MT1
Hashimoto, T1
Hirose, T1
Obara, T1
Inoue, R1
Asayama, K1
Kanno, A1
Totsune, K1
Hoshi, H1
Satoh, H1
Imai, Y1
Smith, JH1
Lindor, NM1
Rabinstein, AA1
Kisaka, T1
Ozono, R1
Ishida, T1
Higashi, Y1
Oshima, T1
Kihara, Y1
Di Legge, S1
Tamayo, A1
Hachinski, V1
Rigsby, CS2
Cannady, WE1
Dorrance, AM3
Otani, L1
Yasumatsu, T1
Murakami, M1
Hayashi, A1
Kimoto, K1
Murakami, T1
Osmond, JM1
Smeda, J1
Vasdev, S1
King, SR1
Enea, I1
De Paolis, P1
Porcellini, A1
Piras, O1
Savoia, C1
Russo, R1
Giliberti, R1
Gigante, B1
Rubattu, S1
Conte, G1
Ganten, D1
Volpe, M1
Takeda, Y1
Yoneda, T1
Demura, M1
Furukawa, K1
Miyamori, I1
Mabuchi, H1
Rocha, R1
Stier, CT1
Osborn, HL1
Grekin, R1
Webb, RC1
Naruse, M1
Tanabe, A1
Sato, A1
Takagi, S1
Tsuchiya, K1
Imaki, T1
Takano, K1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prevalence of Primary Aldosteronism in Patients With Stroke[NCT03789357]300 participants (Actual)Observational2018-05-01Completed
Effect of Mineralcorticoid Recept Antagonist on Cardiovascular Disease in Patients With Hypertension and Hyperaldosteronemia:A Multicenter Randomized Controlled Study[NCT05688579]Phase 48,000 participants (Anticipated)Interventional2023-04-16Enrolling by invitation
Evaluating the Impact of SomaSignal Tests on Medical Management and Change in Risk in Patients at Higher Risk of Cardiovascular Disease: A Feasibility and an Adaptive Implementation Study (SomaSignal Study)[NCT04836117]200 participants (Anticipated)Interventional2021-08-12Recruiting
Phase 3 Multi Center, Double Blind, Randomized, Parallel Group Evaluation Of The Fixed Combination Torcetrapib/Atorvastatin, Administered Orally, Once Daily (Qd), Compared With Atorvastatin Alone, On The Occurrence Of Major Cardiovascular Events In Subjec[NCT00134264]Phase 315,067 participants (Actual)Interventional2004-07-31Terminated
A Safety and Feasibility Study of Water-only Fasting and Refeeding for Treatment of Stage 1 and 2 Hypertensive Patients[NCT04515095]30 participants (Actual)Interventional2020-08-16Completed
A Randomized, Double-blind, Placebo-controlled Study Assessing the Effect of RO4607381 on Cardiovascular Mortality and Morbidity in Clinically Stable Patients With a Recent Acute Coronary Syndrome[NCT00658515]Phase 315,871 participants (Actual)Interventional2008-04-30Completed
Technology Assisted Management of Uncontrolled Hypertension (TEAM-HTN): a Pilot Study[NCT03281772]180 participants (Anticipated)Observational2017-01-24Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline for HDL Cholesterol

(NCT00658515)
Timeframe: At 53 Months

Interventionmg/dL (Least Squares Mean)
Dalcetrapib (RO4607381)44.96
Placebo15.60

Composite Endpoint:All Cause Mortality

(NCT00658515)
Timeframe: Throughout Study, up to 53 Months

InterventionParticipants (Count of Participants)
Dalcetrapib (RO4607381)226
Placebo229

Incidence of Cardiovascular Mortality and Morbidity

Number of cardiovascular events per patient per year (NCT00658515)
Timeframe: From date of randomization to first event up to 48 months

InterventionEvent per Patient Years of Followup (Number)
Dalcetrapib (RO4607381)0.034050
Placebo0.032759

Reviews

9 reviews available for aldosterone and Apoplexy

ArticleYear
Aldosterone and cardiovascular diseases.
    Cardiovascular research, 2023, 03-17, Volume: 119, Issue:1

    Topics: Aldosterone; Atherosclerosis; Atrial Fibrillation; Cardiovascular Diseases; Heart Failure; Humans; H

2023
Promise of Physiological Profiling to Prevent Stroke in People of African Ancestry: Prototyping Ghana.
    Current neurology and neuroscience reports, 2022, Volume: 22, Issue:11

    Topics: Aldosterone; Antihypertensive Agents; Ghana; Humans; Hypertension; Multicenter Studies as Topic; Ren

2022
    Proceedings. Mathematical, physical, and engineering sciences, 2019, Volume: 475, Issue:2227

    Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P

2019
Inhibition of the renin-angiotensin-aldosterone system for cerebrorenal protection.
    Contributions to nephrology, 2013, Volume: 179

    Topics: Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihyperte

2013
Aldosterone as an independent factor in cerebrovascular damage.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2008, Volume: 30, Issue:8

    Topics: Aldosterone; Animals; Blood Pressure; Cerebrovascular Disorders; Disease Models, Animal; Humans; Hyp

2008
[Non-steroidal anti-inflammatory drugs and risk of stroke in older patients: current controversies and research directions].
    Giornale italiano di cardiologia (2006), 2011, Volume: 12, Issue:5

    Topics: Age Factors; Aged; Aged, 80 and over; Aldosterone; Anti-Inflammatory Agents, Non-Steroidal; Atherosc

2011
Aldosterone: good guy or bad guy in cerebrovascular disease?
    Trends in endocrinology and metabolism: TEM, 2005, Volume: 16, Issue:9

    Topics: Aldosterone; Animals; Humans; Mineralocorticoids; Receptors, Mineralocorticoid; Stroke

2005
Is the mineralocorticoid receptor a potential target for stroke prevention?
    Clinical science (London, England : 1979), 2008, Volume: 114, Issue:1

    Topics: Aldosterone; Animals; Cerebrovascular Circulation; Collagen; ErbB Receptors; Humans; Mineralocortico

2008
Pathophysiological effects of aldosterone in cardiovascular tissues.
    Trends in endocrinology and metabolism: TEM, 2001, Volume: 12, Issue:7

    Topics: Adrenalectomy; Aldosterone; Animals; Cardiovascular Diseases; Cerebral Hemorrhage; Humans; Hypertens

2001

Trials

1 trial available for aldosterone and Apoplexy

ArticleYear
Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib.
    Circulation, 2018, 03-06, Volume: 137, Issue:10

    Topics: Aged; Aldosterone; Anticholesteremic Agents; Biomarkers, Pharmacological; Case-Control Studies; Chol

2018
Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib.
    Circulation, 2018, 03-06, Volume: 137, Issue:10

    Topics: Aged; Aldosterone; Anticholesteremic Agents; Biomarkers, Pharmacological; Case-Control Studies; Chol

2018
Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib.
    Circulation, 2018, 03-06, Volume: 137, Issue:10

    Topics: Aged; Aldosterone; Anticholesteremic Agents; Biomarkers, Pharmacological; Case-Control Studies; Chol

2018
Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib.
    Circulation, 2018, 03-06, Volume: 137, Issue:10

    Topics: Aged; Aldosterone; Anticholesteremic Agents; Biomarkers, Pharmacological; Case-Control Studies; Chol

2018

Other Studies

33 other studies available for aldosterone and Apoplexy

ArticleYear
Primary Aldosteronism More Prevalent in Patients With Cardioembolic Stroke and Atrial Fibrillation.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Aldosterone; Atrial Fibrillation; Embolic Stroke; Humans; Hyperaldosteronism; Hypertension; Renin; S

2022
Screening for unilateral aldosteronism should be combined with the maximum systolic blood pressure, history of stroke and typical nodules.
    Medicine, 2022, Oct-28, Volume: 101, Issue:43

    Topics: Adrenal Glands; Aldosterone; Blood Pressure; China; Humans; Hyperaldosteronism; Hyperplasia; Middle

2022
The DOCA-Salt Model of Hypertension for Studies of Cerebrovascular Function, Stroke, and Brain Health.
    Methods in molecular biology (Clifton, N.J.), 2023, Volume: 2616

    Topics: Acetates; Aldosterone; Brain; Desoxycorticosterone Acetate; Humans; Hypertension; Renin-Angiotensin

2023
Primary aldosteronism in young adults with acute stroke: Prevalence and clinical characteristics.
    Journal of the neurological sciences, 2020, 06-15, Volume: 413

    Topics: Aldosterone; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Middle Aged; Prevalence; Stroke;

2020
Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.
    The Journal of international medical research, 2020, Volume: 48, Issue:9

    Topics: Adult; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Card

2020
Fabry disease patients have an increased risk of stroke in the COVID-19 ERA. A hypothesis.
    Medical hypotheses, 2020, Volume: 144

    Topics: Aldosterone; Angiotensin-Converting Enzyme 2; COVID-19; Endothelium, Vascular; Fabry Disease; Female

2020
Allisartan isoproxil reduces mortality of stroke-prone rats and protects against cerebrovascular, cardiac, and aortic damage.
    Acta pharmacologica Sinica, 2021, Volume: 42, Issue:6

    Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Aorti

2021
Aldosterone, Renin, Cardiovascular Events, and All-Cause Mortality Among African Americans: The Jackson Heart Study.
    JACC. Heart failure, 2017, Volume: 5, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Black or African American; Body Mass Index; Cardiovascu

2017
Renin and aldosterone are not associated with vulnerable plaque characteristics in patients with carotid artery disease.
    Journal of vascular surgery, 2018, Volume: 68, Issue:1

    Topics: Aged; Aldosterone; Biomarkers; Carotid Artery Diseases; Chi-Square Distribution; Endarterectomy, Car

2018
Aldosterone, Hypertension, and Antihypertensive Therapy: Insights From a General Population.
    Mayo Clinic proceedings, 2018, Volume: 93, Issue:8

    Topics: Aged; Aldosterone; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Glucose; Cholesterol, L

2018
Aldosterone, Hypertension, and Antihypertensive Therapy: Insights From a General Population.
    Mayo Clinic proceedings, 2018, Volume: 93, Issue:8

    Topics: Aged; Aldosterone; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Glucose; Cholesterol, L

2018
Aldosterone, Hypertension, and Antihypertensive Therapy: Insights From a General Population.
    Mayo Clinic proceedings, 2018, Volume: 93, Issue:8

    Topics: Aged; Aldosterone; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Glucose; Cholesterol, L

2018
Aldosterone, Hypertension, and Antihypertensive Therapy: Insights From a General Population.
    Mayo Clinic proceedings, 2018, Volume: 93, Issue:8

    Topics: Aged; Aldosterone; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Glucose; Cholesterol, L

2018
Serum Aldosterone Is Associated with Cerebral Artery Atherosclerosis and Calcification.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019, Volume: 28, Issue:3

    Topics: Aged; Aldosterone; Biomarkers; Cerebral Angiography; Cerebral Arteries; China; Computed Tomography A

2019
Long-term prehypertension treatment with losartan effectively prevents brain damage and stroke in stroke-prone spontaneously hypertensive rats.
    International journal of molecular medicine, 2014, Volume: 33, Issue:2

    Topics: Aldosterone; Amlodipine; Angiotensin II; Animals; Apoptosis; Blood Pressure; Brain; Hypertension; Lo

2014
Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat.
    Journal of hypertension, 2014, Volume: 32, Issue:10

    Topics: Aldosterone; Animals; Chromosomes; Genotype; Hypertension; Kidney; Male; Quantitative Trait Loci; Ra

2014
RAAS and stress markers in acute ischemic stroke: preliminary findings.
    Acta neurologica Scandinavica, 2015, Volume: 131, Issue:2

    Topics: Aged; Aged, 80 and over; Aldosterone; Angiotensin II; Animals; Biomarkers; Blood Pressure; Female; H

2015
Primary aldosteronism presenting with an atypical aldosterone-renin ratio in the acute phase of cerebral hemorrhage.
    Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:4

    Topics: Adult; Aldosterone; Cerebral Hemorrhage; Early Diagnosis; Humans; Hyperaldosteronism; Male; Renin; S

2015
Forced Expiratory Volume in the First Second and Aldosterone as Mediators of Smoking Effect on Stroke in African Americans: The Jackson Heart Study.
    Journal of the American Heart Association, 2016, Jan-27, Volume: 5, Issue:1

    Topics: Adult; Aged; Aldosterone; Biomarkers; Black or African American; Blood Pressure; Female; Forced Expi

2016
Primary aldosteronism in patients with acute stroke: prevalence and diagnosis during initial hospitalization.
    BMC neurology, 2016, Sep-17, Volume: 16

    Topics: Aged; Aldosterone; Comorbidity; Female; Hospitalization; Humans; Hyperaldosteronism; Hypertension; J

2016
High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension.
    American journal of hypertension, 2017, 05-01, Volume: 30, Issue:5

    Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Black People; Blood Pressure; Cytochrome P-450

2017
Aldosterone Does Not Predict Cardiovascular Events Following Acute Coronary Syndrome in Patients Initially Without Heart Failure.
    Journal of the American Heart Association, 2017, 01-10, Volume: 6, Issue:1

    Topics: Acute Coronary Syndrome; Aged; Aldosterone; Amides; Angina, Unstable; Anticholesteremic Agents; Card

2017
Aldosterone levels and stroke incidence in essential hypertensive patients.
    International journal of cardiology, 2010, Sep-24, Volume: 144, Issue:1

    Topics: Aldosterone; Blood Pressure; Cross-Sectional Studies; Female; Follow-Up Studies; Greece; Humans; Hyp

2010
Cardiovascular complications of patients with aldosteronism associated with autonomous cortisol secretion.
    The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Circadian Rhythm; Cross-Sectional Studies; Female; Hear

2011
Aldosterone, mortality, and acute ischaemic events in coronary artery disease patients outside the setting of acute myocardial infarction or heart failure.
    European heart journal, 2012, Volume: 33, Issue:2

    Topics: Age Factors; Aged; Aldosterone; Angioplasty, Balloon, Coronary; Body Mass Index; Brain Ischemia; C-R

2012
Activation of mineralocorticoid receptors in the rostral ventrolateral medulla is involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:4

    Topics: Aldosterone; Animals; Blood Pressure; Eplerenone; Hypertension; Male; Medulla Oblongata; Microinject

2012
Aldosterone-to-renin ratio as a predictor of stroke under conditions of high sodium intake: the Ohasama study.
    American journal of hypertension, 2012, Volume: 25, Issue:7

    Topics: Adult; Aged; Aldosterone; Female; Humans; Hypertension; Incidence; Japan; Male; Middle Aged; Prospec

2012
Cerebrovascular consequences of pseudohyperaldosteronism.
    Journal of clinical hypertension (Greenwich, Conn.), 2012, Volume: 14, Issue:8

    Topics: Adolescent; Adult; Aged; Aldosterone; Child; Child, Preschool; Cohort Studies; Epithelial Sodium Cha

2012
Association of elevated plasma aldosterone-to-renin ratio with future cardiovascular events in patients with essential hypertension.
    Journal of hypertension, 2012, Volume: 30, Issue:12

    Topics: Adult; Aged; Aldosterone; Asian People; Cardiovascular Diseases; Cohort Studies; Essential Hypertens

2012
Serum potassium level and dietary potassium intake as risk factors for stroke.
    Neurology, 2003, Jun-10, Volume: 60, Issue:11

    Topics: Aged; Aldosterone; Humans; Hyperaldosteronism; Hypertension; Potassium; Potassium, Dietary; Renin; R

2003
Reduction of salt sensitivity in stroke-prone spontaneously hypertensive rats administered an AT1 receptor antagonist during suckling.
    American journal of hypertension, 2006, Volume: 19, Issue:9

    Topics: Albuminuria; Aldosterone; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; An

2006
Effect of poststroke captopril treatment on mortality associated with hemorrhagic stroke in stroke-prone rats.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2

    Topics: Aldosterone; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Captopril;

1999
Defective suppression of the aldosterone biosynthesis during stroke permissive diet in the stroke-prone phenotype of the spontaneously hypertensive rat.
    Basic research in cardiology, 2000, Volume: 95, Issue:2

    Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Hypertension; Japan; Male; Rats; Rats, Inbred SHR;

2000
Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats.
    Journal of hypertension, 2001, Volume: 19, Issue:3 Pt 2

    Topics: Aldosterone; Animals; Cardiovascular System; Diet; Genetic Predisposition to Disease; Hypertension;

2001
Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 281, Issue:3

    Topics: Aldosterone; Animals; Aorta; Basal Ganglia; Blood Pressure; Body Weight; Cerebral Cortex; Cerebral I

2001
Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:1

    Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals;

2002