aldosterone and Apnea, Sleep studies

Research Excerpts

Excerpt	Relevance	Reference
"Obstructive sleep apnea can be detected with a careful history and various sleep studies."	5.32	Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. ( Calhoun, DA; Goodfriend, TL, 2004)
"Primary hyperaldosteronism is not as uncommon as previously thought, but its prevalence depends on the selected population."	1.34	Resistant hypertension: a methodological approach to diagnosis and treatment. ( Tamimi, NA, 2007)
"Obstructive sleep apnea can be detected with a careful history and various sleep studies."	1.32	Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. ( Calhoun, DA; Goodfriend, TL, 2004)
"To assess the effect of obstructive sleep apnea treatment on plasma renin activity (PRA) and plasma aldosterone seven male patients were studied under two conditions: untreated and treated with nasal continuous positive airways pressure (CPAP)."	1.28	Obstructive sleep apnea treatment: peripheral and central effects on plasma renin activity and aldosterone. ( Brandenberger, G; Follenius, M; Krauth, MO; Krieger, J; Sforza, F, 1991)
"Obstructive sleep apnea (OSA) patients have increased diuresis and natriuresis during sleep."	1.28	[Renal function and sleep apnea syndromes]. ( Barthelmebs, M; Coumaros, G; Imbs, JL; Krieger, J; Kurtz, D; Lehr, L; Sforza, E, 1989)

Research

Studies (13)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Epworth Sleepiness Score (ESS)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (15.38)	18.7374
1990's	6 (46.15)	18.2507
2000's	3 (23.08)	29.6817
2010's	2 (15.38)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Ke, X	1
Guo, W	1
Peng, H	1
Hu, C	1
Zhang, H	1
Peng, C	1
Wang, X	1
Martinez, FA	1
Goodfriend, TL	1
Calhoun, DA	1
Tamimi, NA	1
Mackay, TW	1
Fitzpatrick, MF	1
Freestone, S	1
Lee, MR	1
Douglas, NJ	1
Krieger, J	3
Saarelainen, S	1
Hasan, J	1
Siitonen, S	1
Seppälä, E	1
Maillard, D	1
Fineyre, F	1
Dreyfuss, D	1
Djedaini, K	1
Blanchet, F	1
Paycha, F	1
Dussaule, JC	1
Nitenberg, A	1
Hedner, J	1
Xiao, Y	1
Yin, K	1
Zheng, P	1
Follenius, M	1
Krauth, MO	1
Sforza, F	1
Brandenberger, G	1
Sforza, E	1
Barthelmebs, M	1
Imbs, JL	1
Lehr, L	1
Coumaros, G	1
Kurtz, D	1
Coccagna, G	1
Martinelli, P	1
Zucconi, M	1
Cirignotta, F	1
Ambrosetto, G	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Efficacy of Continuous Positive Airway Pressure (CPAP) on Blood Pressure Control of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome (OSAS).[NCT01508754]	Phase 4	125 participants (Actual)	Interventional	2012-01-31	Completed
Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea[NCT01196117]		18 participants (Actual)	Interventional	2004-11-15	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Epworth Sleepiness Score (ESS) is a scale to assess sleepiness during waking hours. The scale ranges from 0-24 with higher scores indicative of greater sleepiness. (NCT01196117)
Timeframe: Difference between Baseline(Day 0) and Average of Day 1,7,14.

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~ 7am, Day 7

Intervention	units on a scale (Median)
14 Days of Placebo Therapy, Then CPAP	10.7
14 Days of CPAP Therapy	8.9

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 7, 7am

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 0

Intervention	nmol/l (Mean)
CPAP>= 3 Hours Per Night	9.9
CPAP<3 Hours Per Night	13.3

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 0, 11pm

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 1

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	3.2
CPAP<3 Hours Per Night	1.2

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 1, 11pm

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 14

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	2.2
CPAP<3 Hours Per Night	1.8

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 14, 11pm

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 7

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	1.9
CPAP<3 Hours Per Night	2.2

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 7, 11pm

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~7am, Day 0

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	3.0
CPAP<3 Hours Per Night	2.5

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 0, 7am

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~7am, Day 1

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	12.5
CPAP<3 Hours Per Night	12.1

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 1, 7am

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~7am, Day 14

Intervention	nmol/l (Median)
CPAP>= 3 Hours Per Night	7.4
CPAP<3 Hours Per Night	13.6

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 14, 7am

Article	Year
Association of aldosterone excess and apnea-hypopnea index in patients with resistant hypertension. Scientific reports, 2017, 03-22, Volume: 7 Topics: Aged; Aldosterone; Coronary Vasospasm; Female; Humans; Hypertension; Male; Middle Aged; Sleep Apnea	2017
Aldosterone inhibition and cardiovascular protection: more important than it once appeared. Cardiovascular drugs and therapy, 2010, Volume: 24, Issue:4 Topics: Aldosterone; Atherosclerosis; Blood Vessels; Cardiomegaly; Cardiotonic Agents; Endothelium; Heart Fa	2010
Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:3 Topics: Aldosterone; Antihypertensive Agents; Drug Resistance; Humans; Hypertension; Male; Middle Aged; Mode	2004
Resistant hypertension: a methodological approach to diagnosis and treatment. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2007, Volume: 18, Issue:3 Topics: Aldosterone; Diagnosis, Differential; Drug Resistance; Humans; Hyperaldosteronism; Hypertension; Pat	2007
Hormonal control of sodium and water excretion in obstructive sleep apnoea. Scandinavian journal of urology and nephrology. Supplementum, 1995, Volume: 173 Topics: Aldosterone; Atrial Natriuretic Factor; Body Water; Guanosine Monophosphate; Hemodynamics; Humans; P	1995
Effect of nasal CPAP treatment on plasma volume, aldosterone and 24-h blood pressure in obstructive sleep apnoea. Journal of sleep research, 1996, Volume: 5, Issue:3 Topics: Adult; Aldosterone; Heart Rate; Humans; Male; Middle Aged; Positive-Pressure Respiration; Random All	1996
Pressure-heart rate responses to alpha-adrenergic stimulation and hormonal regulation in normotensive patients with obstructive sleep apnea. American journal of hypertension, 1997, Volume: 10, Issue:1 Topics: Adrenergic alpha-Agonists; Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Heart Rate	1997
[Significance of the changes of urinary uric acid, ANP, renin and aldosterone in sleep apnea syndrome patients]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2000, Volume: 23, Issue:1 Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Creatinine; Female; Humans; Male; Middle Aged; Renin;	2000
Obstructive sleep apnea treatment: peripheral and central effects on plasma renin activity and aldosterone. Sleep, 1991, Volume: 14, Issue:3 Topics: Adult; Aldosterone; Blood Volume; Humans; Hydrocortisone; Male; Oxygen; Positive-Pressure Respiratio	1991
[Renal function and sleep apnea syndromes]. Neurophysiologie clinique = Clinical neurophysiology, 1989, Volume: 19, Issue:3 Topics: Adult; Aldosterone; Creatinine; Cyclic GMP; Diuresis; Humans; Kidney; Male; Middle Aged; Natriuresis	1989
Sleep-related respiratory and haemodynamic changes in Shy-Drager syndrome: a case report. Journal of neurology, 1985, Volume: 232, Issue:5 Topics: Aldosterone; Autonomic Nervous System Diseases; Blood Pressure; Heart Rate; Humans; Male; Middle Age	1985

aldosterone and Apnea, Sleep