alcian-blue and Skin-Diseases

alcian-blue has been researched along with Skin-Diseases* in 2 studies

Other Studies

2 other study(ies) available for alcian-blue and Skin-Diseases

Article	Year
Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin. The American journal of pathology, 1992, Volume: 140, Issue:3 Platelet-derived growth factor (PDGF) is known to stimulate the proliferation of connective tissue-derived cells in vitro. Less is known about its functions in vivo, and the role of PDGF in the development of human tumors has not been clarified. The authors have investigated the occurrence of PDGF and PDGF receptors in a series of proliferative disorders of fibroblastic origin using immunohistochemical and in situ hybridization techniques. High expression of PDGF beta-receptor mRNA and protein was found in the malignant tumors, and also in some benign lesions, such as dermatofibroma. In all these cases, benign as well as malignant, the PDGF B-chain mRNA, and less clearly, the PDGF A-chain mRNA, were coexpressed with the beta-receptor. In contrast, high expression of PDGF alpha-receptor mRNA was only found in fully malignant lesions, i.e., malignant fibrous histiocytoma. These data indicate that an autocrine growth stimulation via the PDGF beta-receptor could occur in an early phase of tumorigenesis, and may be a necessary but insufficient event for the progression into fully malignant human connective tissue lesions. Topics: Alcian Blue; Antibody Specificity; Fibroblasts; Humans; Immunohistochemistry; Neoplasms; Nucleic Acid Hybridization; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Skin Diseases; Staining and Labeling	1992
[Structural-functional characteristics of the surface of the blood mononucleocytes in children suffering from chronic dermatoses. I. The correction of the glycocalyx structure by UV irradiation of the blood and in the course of treatment with an autotrans Tsitologiia, 1988, Volume: 30, Issue:5 In children suffering from chronic dermatoses (psoriasis and neurodermatitis), the glycocalix of blood mononuclears displays an Alcian blue dye sorption by 23-25% less than that in healthy children. The UV irradiation of their blood (254 nm), in addition to a course of UV-irradiated blood autotransfusion, resulted in an elevated sorption capacity of the mononuclear glycocalix up to the normal. A possible involvement of these changes in immunocompetent cell glycocalix in the pathogenesis of chronic dermatoses is discussed, as well as the significance of glycocalix normalization in the medicinal effect of UV-irradiated blood autotransfusion. Topics: Absorption; Adolescent; Alcian Blue; Blood Transfusion, Autologous; Child; Chronic Disease; Combined Modality Therapy; Glycoproteins; Humans; Leukocytes, Mononuclear; Neurodermatitis; Polysaccharides; Psoriasis; Skin Diseases; Surface Properties; Ultraviolet Therapy	1988

Article

Year

Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin.

The American journal of pathology, 1992, Volume: 140, Issue:3

Platelet-derived growth factor (PDGF) is known to stimulate the proliferation of connective tissue-derived cells in vitro. Less is known about its functions in vivo, and the role of PDGF in the development of human tumors has not been clarified. The authors have investigated the occurrence of PDGF and PDGF receptors in a series of proliferative disorders of fibroblastic origin using immunohistochemical and in situ hybridization techniques. High expression of PDGF beta-receptor mRNA and protein was found in the malignant tumors, and also in some benign lesions, such as dermatofibroma. In all these cases, benign as well as malignant, the PDGF B-chain mRNA, and less clearly, the PDGF A-chain mRNA, were coexpressed with the beta-receptor. In contrast, high expression of PDGF alpha-receptor mRNA was only found in fully malignant lesions, i.e., malignant fibrous histiocytoma. These data indicate that an autocrine growth stimulation via the PDGF beta-receptor could occur in an early phase of tumorigenesis, and may be a necessary but insufficient event for the progression into fully malignant human connective tissue lesions.

Topics: Alcian Blue; Antibody Specificity; Fibroblasts; Humans; Immunohistochemistry; Neoplasms; Nucleic Acid Hybridization; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Skin Diseases; Staining and Labeling

1992

[Structural-functional characteristics of the surface of the blood mononucleocytes in children suffering from chronic dermatoses. I. The correction of the glycocalyx structure by UV irradiation of the blood and in the course of treatment with an autotrans

Tsitologiia, 1988, Volume: 30, Issue:5

In children suffering from chronic dermatoses (psoriasis and neurodermatitis), the glycocalix of blood mononuclears displays an Alcian blue dye sorption by 23-25% less than that in healthy children. The UV irradiation of their blood (254 nm), in addition to a course of UV-irradiated blood autotransfusion, resulted in an elevated sorption capacity of the mononuclear glycocalix up to the normal. A possible involvement of these changes in immunocompetent cell glycocalix in the pathogenesis of chronic dermatoses is discussed, as well as the significance of glycocalix normalization in the medicinal effect of UV-irradiated blood autotransfusion.

Topics: Absorption; Adolescent; Alcian Blue; Blood Transfusion, Autologous; Child; Chronic Disease; Combined Modality Therapy; Glycoproteins; Humans; Leukocytes, Mononuclear; Neurodermatitis; Polysaccharides; Psoriasis; Skin Diseases; Surface Properties; Ultraviolet Therapy

1988