alcian-blue and Coronary-Disease

The two structural-functional state parameters of erythrocyte membrane in healthy donors and ischemic heart disease patients have been compared--the potassium exchange rate constant (x), and the quantity of Alcian blue sorption capacity of glycocalyx (y). The connection between the first parameter--x--and the other one--y--has been observed in cases, when the value of the latter experienced both the seasonal oscillations (the coefficient of lineal correlation was: r = -0.87, P less than 0.01) and the changes in the cause of ischemic heart disease (r = -0.72, P less than 0.01) and its treatment (the coefficients of correlation attitude of each of parameter changes were: eta xy = 0.83, P less than 0.01; eta yx = 0.52, P less than 0.05). The above connection may indicate the participation of membrane glycoproteins and glycolipids in a regulation of the cation transport function of the erythrocyte membrane.

Topics: Absorption; Alcian Blue; Biological Transport; Blood Donors; Blood Transfusion, Autologous; Combined Modality Therapy; Coronary Disease; Erythrocyte Membrane; Glycoproteins; Humans; Polysaccharides; Potassium; Rubidium; Ultraviolet Therapy

It was shown that fructose-1.6-diphosphate was capable of marked suppression of the aggregation power of the blood erythrocytes of patients with acute myocardial infarction and angina of effort. The antiaggregation effect of the drug was dose-related and enhanced with an increase in the time of its contact with erythrocytes. The antiaggregation effect of pentoxifylline was not of distinct dose-related nature. Its antiaggregation power did not considerably depend on the time of incubation with erythrocytes.

Topics: Adult; Aged; Alcian Blue; Angina Pectoris; Coronary Disease; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythrocyte Aggregation; Female; Fructosediphosphates; Hexosediphosphates; Humans; Male; Middle Aged; Myocardial Infarction; Pentoxifylline; Theobromine