alcian-blue and Colorectal-Neoplasms

This study aimed to assess the qualitative changes in the amount of acid mucin in colorectal carcinoma (CRC) compared to normal colon.. A total number of 100 samples were examined, 50 were colorectal cancer samples (cases) and 50 were normal (controls), all were stained with Alcian blue method.. Acid mucin increased, in different levels, in 30 (60%) of the cases compared to only six (12%) of controls (P < 0.0001). However, complete absence of acid mucin was detected among 10 (20%) of cases compared to none among controls.. CRC is associated with secretion of increased amounts of acid mucin in most cases, and that should be considered as a valuable histological finding.

Topics: Adenocarcinoma; Alcian Blue; Colorectal Neoplasms; Coloring Agents; Humans; Mucins; Sudan