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albuterol and Pulmonary Hypertension

albuterol has been researched along with Pulmonary Hypertension in 9 studies

Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Research Excerpts

ExcerptRelevanceReference
"A two-year-old child dying of pulmonary hypertension and cor pulmonale secondary to bronchopulmonary dysplasia, was demonstrated to have reactive pulmonary hypertension in response to 100% oxygen and isoproterenol infusion."9.06Treatment of pulmonary hypertension with diltiazem in a child with bronchopulmonary dysplasia. ( Bingham, WT; Duncan, WJ; Kasian, GF; Mersal, A; Ninan, A; Sankaran, K; Tyrrell, MJ, 1988)
"We studied patients with pulmonary hypertension who had evidence of bronchial responsiveness to inhaled albuterol."8.80Airway responsiveness to inhaled albuterol in patients with pulmonary hypertension. ( Arroliga, A; O'Hagan, AR; Stillwell, PC, 1999)
"A two-year-old child dying of pulmonary hypertension and cor pulmonale secondary to bronchopulmonary dysplasia, was demonstrated to have reactive pulmonary hypertension in response to 100% oxygen and isoproterenol infusion."5.06Treatment of pulmonary hypertension with diltiazem in a child with bronchopulmonary dysplasia. ( Bingham, WT; Duncan, WJ; Kasian, GF; Mersal, A; Ninan, A; Sankaran, K; Tyrrell, MJ, 1988)
"We studied patients with pulmonary hypertension who had evidence of bronchial responsiveness to inhaled albuterol."4.80Airway responsiveness to inhaled albuterol in patients with pulmonary hypertension. ( Arroliga, A; O'Hagan, AR; Stillwell, PC, 1999)
"Chronic hypoxia produces polycythemia, pulmonary hypertension, muscularization of peripheral pulmonary arteries, and right ventricular hypertrophy."1.27The effect of systemic beta-2 adrenergic agonist therapy on the pulmonary hypertensive response to chronic hypoxia in rats. ( Collins, C; Rudd, RM; Ruddock, PE; Winter, R, 1986)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19904 (44.44)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Spiekerkoetter, E1
Fabel, H1
Hoeper, MM1
O'Hagan, AR1
Stillwell, PC1
Arroliga, A1
Crilley, JG1
Dark, JH1
Hall, JA1
Sartori, C1
Allemann, Y1
Duplain, H1
Lepori, M1
Egli, M1
Lipp, E1
Hutter, D1
Turini, P1
Hugli, O1
Cook, S1
Nicod, P1
Scherrer, U1
Winter, RJ1
Rudd, RM2
Winter, R1
Collins, C1
Ruddock, PE1
Kasian, GF1
Ninan, A1
Duncan, WJ1
Bingham, WT1
Mersal, A1
Tyrrell, MJ1
Sankaran, K1
Levison, H1
Collins-Williams, C1
Bryan, AC1
Reilly, BJ1
Orange, RP1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Albuterol and Dynamic Hyperinflation in Idiopathic Pulmonary Arterial Hypertension[NCT02108743]Phase 20 participants (Actual)Interventional2014-06-30Withdrawn (stopped due to Lack of funding)
The Effect of Nebulized Albuterol on Donor Oxygenation[NCT00310401]Phase 2506 participants (Actual)Interventional2007-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Donor Oxygenation

The primary outcome was the change in oxygenation as measured by change in the PaO2/FiO2 ratio from study enrollment to organ procurement (NCT00310401)
Timeframe: Change from enrollment to organ procurement (about ~40h after enrollment)

InterventioncmH2O (Median)
Albuterol49
Saline40

Number of Donor Lungs Used for Transplantation

Number of lungs procured and used for transplantation (NCT00310401)
Timeframe: 72 hours

InterventionParticipants (Count of Participants)
Albuterol74
Saline78

Chest X-ray Findings

Chest radiographs were scored using a radiographic score that scored each quadrant for extent of radiographic infiltrates on a scale of 0 to 4, then summed each quadrant for a total score from 0 (no infiltrates) to 16 (extensive infiltrates in all 4 radiographic quadrants). (NCT00310401)
Timeframe: change from enrollment to organ procurement (about ~40h after enrollment)

,
Interventionunits on a scale (Mean)
Enrollmentat organ procurement (about ~40h after enrollment)
Albuterol4.75.0
Saline4.64.4

Lung Compliance

Static compliance of the respiratory system using plateau pressure (Pplat) measured at end-inspiration and calculated using the equation static compliance = tidal volume/(Pplat - PEEP) (NCT00310401)
Timeframe: baseline and at organ procurement (about ~40h after enrollment)

,
Interventionml/cmH2O (Mean)
baselineat organ procurement (mean ~40h after enrollment)
Albuterol4852
Saline5056

Reviews

2 reviews available for albuterol and Pulmonary Hypertension

ArticleYear
Airway responsiveness to inhaled albuterol in patients with pulmonary hypertension.
    Clinical pediatrics, 1999, Volume: 38, Issue:1

    Topics: Adolescent; Adult; Airway Resistance; Albuterol; Bronchodilator Agents; Bronchography; Child; Eisenm

1999
Asthma: current concepts.
    Pediatric clinics of North America, 1974, Volume: 21, Issue:4

    Topics: Adolescent; Albuterol; Asthma; Beclomethasone; Bronchodilator Agents; Carboxylic Acids; Child; Child

1974

Trials

3 trials available for albuterol and Pulmonary Hypertension

ArticleYear
Effects of inhaled salbutamol in primary pulmonary hypertension.
    The European respiratory journal, 2002, Volume: 20, Issue:3

    Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Bronchodilator Agents; Cardiac Outp

2002
Salmeterol for the prevention of high-altitude pulmonary edema.
    The New England journal of medicine, 2002, May-23, Volume: 346, Issue:21

    Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Altitude Sickness; Biologica

2002
Treatment of pulmonary hypertension with diltiazem in a child with bronchopulmonary dysplasia.
    The Canadian journal of cardiology, 1988, Volume: 4, Issue:4

    Topics: Albuterol; Bronchopulmonary Dysplasia; Child, Preschool; Diltiazem; Humans; Hydralazine; Hypertensio

1988

Other Studies

4 other studies available for albuterol and Pulmonary Hypertension

ArticleYear
You're the Flight Surgeon.
    Aerospace medicine and human performance, 2016, Volume: 87, Issue:9

    Topics: Aerospace Medicine; Albuterol; Bronchodilator Agents; Cardiac Catheterization; Dyspnea; Echocardiogr

2016
Reversal of severe pulmonary hypertension with beta blockade in a patient with end stage left ventricular failure.
    Heart (British Cardiac Society), 1998, Volume: 80, Issue:6

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Cardiac Output; Dobutamine; Drug A

1998
Beta 2 agonists in pulmonary hypertension.
    Lancet (London, England), 1985, Jun-22, Volume: 1, Issue:8443

    Topics: Albuterol; Animals; Humans; Hypertension, Pulmonary; Rats; Rats, Inbred Strains

1985
The effect of systemic beta-2 adrenergic agonist therapy on the pulmonary hypertensive response to chronic hypoxia in rats.
    The American review of respiratory disease, 1986, Volume: 134, Issue:4

    Topics: Adrenergic beta-Agonists; Albuterol; Animals; Blood Viscosity; Cardiomegaly; Hematocrit; Hemodynamic

1986