albuterol has been researched along with Pulmonary Hypertension in 9 studies
Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
| Excerpt | Relevance | Reference |
|---|---|---|
| "A two-year-old child dying of pulmonary hypertension and cor pulmonale secondary to bronchopulmonary dysplasia, was demonstrated to have reactive pulmonary hypertension in response to 100% oxygen and isoproterenol infusion." | 9.06 | Treatment of pulmonary hypertension with diltiazem in a child with bronchopulmonary dysplasia. ( Bingham, WT; Duncan, WJ; Kasian, GF; Mersal, A; Ninan, A; Sankaran, K; Tyrrell, MJ, 1988) |
| "We studied patients with pulmonary hypertension who had evidence of bronchial responsiveness to inhaled albuterol." | 8.80 | Airway responsiveness to inhaled albuterol in patients with pulmonary hypertension. ( Arroliga, A; O'Hagan, AR; Stillwell, PC, 1999) |
| "A two-year-old child dying of pulmonary hypertension and cor pulmonale secondary to bronchopulmonary dysplasia, was demonstrated to have reactive pulmonary hypertension in response to 100% oxygen and isoproterenol infusion." | 5.06 | Treatment of pulmonary hypertension with diltiazem in a child with bronchopulmonary dysplasia. ( Bingham, WT; Duncan, WJ; Kasian, GF; Mersal, A; Ninan, A; Sankaran, K; Tyrrell, MJ, 1988) |
| "We studied patients with pulmonary hypertension who had evidence of bronchial responsiveness to inhaled albuterol." | 4.80 | Airway responsiveness to inhaled albuterol in patients with pulmonary hypertension. ( Arroliga, A; O'Hagan, AR; Stillwell, PC, 1999) |
| "Chronic hypoxia produces polycythemia, pulmonary hypertension, muscularization of peripheral pulmonary arteries, and right ventricular hypertrophy." | 1.27 | The effect of systemic beta-2 adrenergic agonist therapy on the pulmonary hypertensive response to chronic hypoxia in rats. ( Collins, C; Rudd, RM; Ruddock, PE; Winter, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spiekerkoetter, E | 1 |
| Fabel, H | 1 |
| Hoeper, MM | 1 |
| O'Hagan, AR | 1 |
| Stillwell, PC | 1 |
| Arroliga, A | 1 |
| Crilley, JG | 1 |
| Dark, JH | 1 |
| Hall, JA | 1 |
| Sartori, C | 1 |
| Allemann, Y | 1 |
| Duplain, H | 1 |
| Lepori, M | 1 |
| Egli, M | 1 |
| Lipp, E | 1 |
| Hutter, D | 1 |
| Turini, P | 1 |
| Hugli, O | 1 |
| Cook, S | 1 |
| Nicod, P | 1 |
| Scherrer, U | 1 |
| Winter, RJ | 1 |
| Rudd, RM | 2 |
| Winter, R | 1 |
| Collins, C | 1 |
| Ruddock, PE | 1 |
| Kasian, GF | 1 |
| Ninan, A | 1 |
| Duncan, WJ | 1 |
| Bingham, WT | 1 |
| Mersal, A | 1 |
| Tyrrell, MJ | 1 |
| Sankaran, K | 1 |
| Levison, H | 1 |
| Collins-Williams, C | 1 |
| Bryan, AC | 1 |
| Reilly, BJ | 1 |
| Orange, RP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Albuterol and Dynamic Hyperinflation in Idiopathic Pulmonary Arterial Hypertension[NCT02108743] | Phase 2 | 0 participants (Actual) | Interventional | 2014-06-30 | Withdrawn (stopped due to Lack of funding) | ||
| The Effect of Nebulized Albuterol on Donor Oxygenation[NCT00310401] | Phase 2 | 506 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome was the change in oxygenation as measured by change in the PaO2/FiO2 ratio from study enrollment to organ procurement (NCT00310401)
Timeframe: Change from enrollment to organ procurement (about ~40h after enrollment)
| Intervention | cmH2O (Median) |
|---|---|
| Albuterol | 49 |
| Saline | 40 |
Number of lungs procured and used for transplantation (NCT00310401)
Timeframe: 72 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Albuterol | 74 |
| Saline | 78 |
Chest radiographs were scored using a radiographic score that scored each quadrant for extent of radiographic infiltrates on a scale of 0 to 4, then summed each quadrant for a total score from 0 (no infiltrates) to 16 (extensive infiltrates in all 4 radiographic quadrants). (NCT00310401)
Timeframe: change from enrollment to organ procurement (about ~40h after enrollment)
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Enrollment | at organ procurement (about ~40h after enrollment) | |
| Albuterol | 4.7 | 5.0 |
| Saline | 4.6 | 4.4 |
Static compliance of the respiratory system using plateau pressure (Pplat) measured at end-inspiration and calculated using the equation static compliance = tidal volume/(Pplat - PEEP) (NCT00310401)
Timeframe: baseline and at organ procurement (about ~40h after enrollment)
| Intervention | ml/cmH2O (Mean) | |
|---|---|---|
| baseline | at organ procurement (mean ~40h after enrollment) | |
| Albuterol | 48 | 52 |
| Saline | 50 | 56 |
2 reviews available for albuterol and Pulmonary Hypertension
| Article | Year |
|---|---|
Airway responsiveness to inhaled albuterol in patients with pulmonary hypertension.
Topics: Adolescent; Adult; Airway Resistance; Albuterol; Bronchodilator Agents; Bronchography; Child; Eisenm | 1999 |
Asthma: current concepts.
Topics: Adolescent; Albuterol; Asthma; Beclomethasone; Bronchodilator Agents; Carboxylic Acids; Child; Child | 1974 |
3 trials available for albuterol and Pulmonary Hypertension
| Article | Year |
|---|---|
Effects of inhaled salbutamol in primary pulmonary hypertension.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Bronchodilator Agents; Cardiac Outp | 2002 |
Salmeterol for the prevention of high-altitude pulmonary edema.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Altitude Sickness; Biologica | 2002 |
Treatment of pulmonary hypertension with diltiazem in a child with bronchopulmonary dysplasia.
Topics: Albuterol; Bronchopulmonary Dysplasia; Child, Preschool; Diltiazem; Humans; Hydralazine; Hypertensio | 1988 |
4 other studies available for albuterol and Pulmonary Hypertension
| Article | Year |
|---|---|
You're the Flight Surgeon.
Topics: Aerospace Medicine; Albuterol; Bronchodilator Agents; Cardiac Catheterization; Dyspnea; Echocardiogr | 2016 |
Reversal of severe pulmonary hypertension with beta blockade in a patient with end stage left ventricular failure.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Cardiac Output; Dobutamine; Drug A | 1998 |
Beta 2 agonists in pulmonary hypertension.
Topics: Albuterol; Animals; Humans; Hypertension, Pulmonary; Rats; Rats, Inbred Strains | 1985 |
The effect of systemic beta-2 adrenergic agonist therapy on the pulmonary hypertensive response to chronic hypoxia in rats.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Blood Viscosity; Cardiomegaly; Hematocrit; Hemodynamic | 1986 |