Page last updated: 2024-10-22

albuterol and Muscular Dystrophy, Duchenne

albuterol has been researched along with Muscular Dystrophy, Duchenne in 4 studies

Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Muscular Dystrophy, Duchenne: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)

Research Excerpts

ExcerptRelevanceReference
"Fourteen boys with Duchenne or Becker muscular dystrophy, 6 to 11 years old, completed two treatment periods (albuterol and placebo), 12 weeks each, separated by a 12-week washout period."9.13Albuterol increases lean body mass in ambulatory boys with Duchenne or Becker muscular dystrophy. ( Fowler, EG; Graves, M; Skura, CL; Spencer, MJ; Wetzel, GT, 2008)
"Fourteen boys with Duchenne or Becker muscular dystrophy, 6 to 11 years old, completed two treatment periods (albuterol and placebo), 12 weeks each, separated by a 12-week washout period."5.13Albuterol increases lean body mass in ambulatory boys with Duchenne or Becker muscular dystrophy. ( Fowler, EG; Graves, M; Skura, CL; Spencer, MJ; Wetzel, GT, 2008)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fowler, EG2
Graves, MC1
Wetzel, GT2
Spencer, MJ2
Restrepo, S1
Skura, CL1
Graves, M1
Lynch, GS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect on Body Composition With Albuterol and Caffeine Versus Placebo in Adolescents: A Pilot Study[NCT02740660]12 participants (Actual)Interventional2016-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Fat Mass With Caffeine/Albuterol

DXA Scan of obese adolescents (NCT02740660)
Timeframe: Baseline, Week 8

Interventionkg (Mean)
Caffeine 100mg / Albuterol 4mg0.97
Placebo-0.21

Change in Lean Mass With Caffeine/Albuterol

DXA Scan of obese adolescents (NCT02740660)
Timeframe: Baseline, Week 8

Interventionkg (Mean)
Caffeine 100mg / Albuterol 4mg1.34
Placebo0.88

Change in Weight With Caffeine/Albuterol

(NCT02740660)
Timeframe: Baseline, Week 8

Interventionkg (Mean)
Caffeine 100mg / Albuterol 4mg2.57
Placebo1.05

Number of Participants With Adverse Events

(NCT02740660)
Timeframe: Week 2, Week 4, Week 6, Week 8

InterventionParticipants (Count of Participants)
Caffeine 100mg / Albuterol 4mg5
Placebo2

Reviews

1 review available for albuterol and Muscular Dystrophy, Duchenne

ArticleYear
Therapies for improving muscle function in neuromuscular disorders.
    Exercise and sport sciences reviews, 2001, Volume: 29, Issue:4

    Topics: Adjuvants, Immunologic; Adrenergic beta-Agonists; Albuterol; Aminoglycosides; Animals; Anti-Bacteria

2001

Trials

2 trials available for albuterol and Muscular Dystrophy, Duchenne

ArticleYear
Pilot trial of albuterol in Duchenne and Becker muscular dystrophy.
    Neurology, 2004, Mar-23, Volume: 62, Issue:6

    Topics: Adrenergic beta-Agonists; Albuterol; Child; Cross-Over Studies; Double-Blind Method; Dystrophin; Fol

2004
Albuterol increases lean body mass in ambulatory boys with Duchenne or Becker muscular dystrophy.
    Neurology, 2008, Jan-08, Volume: 70, Issue:2

    Topics: Adrenergic beta-Agonists; Albuterol; Body Mass Index; Child; Double-Blind Method; Humans; Male; Musc

2008

Other Studies

1 other study available for albuterol and Muscular Dystrophy, Duchenne

ArticleYear
New treatment alternatives for Duchenne and Becker muscular dystrophy.
    Neurology, 2004, Mar-23, Volume: 62, Issue:6

    Topics: Administration, Oral; Adrenergic beta-Agonists; Albuterol; Child; Child, Preschool; Clinical Trials

2004