Compounds > albuterol
Page last updated: 2024-10-22

albuterol and Genetic Predisposition

albuterol has been researched along with Genetic Predisposition in 12 studies

Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Research Excerpts

ExcerptRelevanceReference
"The homozygous presence of the arginine-16 variant of the beta(2) adrenoceptor gene ADRB2 reverses the benefits from the regular use of short acting beta(2) agonists in asthmatic adults compared with the homozygous glycine-16 genotype."7.73Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol. ( Ismail, T; Lee, S; Lipworth, BJ; Macgregor, DF; Mukhopadhyay, S; Palmer, CN, 2006)
" Asthmatic patients with the Arg19/Arg19 genotype showed decreased responsiveness to albuterol."3.77Relationship between polymorphisms in the 5' leader cistron, positions 16 and 27 of the adrenergic β2 receptor gene and asthma in a Han population from southwest China. ( Dai, LM; Fang, LZ; Fu, WP; Liu, L; Shu, JK; Sun, C; Wang, L; Wang, XM; Zhang, JQ; Zhao, ZH; Zhong, L, 2011)
"The homozygous presence of the arginine-16 variant of the beta(2) adrenoceptor gene ADRB2 reverses the benefits from the regular use of short acting beta(2) agonists in asthmatic adults compared with the homozygous glycine-16 genotype."3.73Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol. ( Ismail, T; Lee, S; Lipworth, BJ; Macgregor, DF; Mukhopadhyay, S; Palmer, CN, 2006)
"Forty-four patients with COPD completed the study."2.73Association of beta2-adrenoreceptor genotypes with bronchodilatory effect of tiotropium in COPD. ( Fujimoto, S; Hirata, K; Kanazawa, H; Umeda, N; Yoshikawa, T, 2008)
"Airway inflammation is a key factor in the mechanisms of asthma."2.42Mechanisms of asthma. ( Busse, WW; Rosenwasser, LJ, 2003)
"Airflow limitation in COPD patients is not fully reversible."1.35Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. ( DeMeo, DL; Hersh, CP; Kim, WJ; Reilly, JJ; Silverman, EK, 2009)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (50.00)29.6817
2010's6 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bandaru, S1
Akka, J1
Marri, VK1
Alvala, M1
Ponnala, D1
Mundluru, HP1
Jabbal, S1
Manoharan, A1
Lipworth, J1
Anderson, W1
Short, P1
Lipworth, B1
Kim, WJ1
Hersh, CP1
DeMeo, DL1
Reilly, JJ1
Silverman, EK1
Schreuder, LT1
Nijhuis-van der Sanden, MW1
de Hair, A1
Peters, G1
Wortmann, S1
Bok, LA1
Morava, E1
Harada, M1
Hirota, T1
Jodo, AI1
Hitomi, Y1
Sakashita, M1
Tsunoda, T1
Miyagawa, T1
Doi, S1
Kameda, M1
Fujita, K1
Miyatake, A1
Enomoto, T1
Noguchi, E1
Masuko, H1
Sakamoto, T1
Hizawa, N2
Suzuki, Y1
Yoshihara, S1
Adachi, M1
Ebisawa, M1
Saito, H1
Matsumoto, K1
Nakajima, T1
Mathias, RA1
Rafaels, N1
Barnes, KC1
Himes, BE1
Duan, QL1
Tantisira, KG1
Weiss, ST1
Nakamura, Y1
Ziegler, SF1
Tamari, M1
Fu, WP1
Zhao, ZH1
Zhong, L1
Sun, C1
Fang, LZ1
Liu, L1
Zhang, JQ1
Wang, L1
Shu, JK1
Wang, XM1
Dai, LM1
Konno, S1
Makita, H1
Hasegawa, M1
Nasuhara, Y1
Nagai, K1
Betsuyaku, T1
Nishimura, M1
Busse, WW1
Rosenwasser, LJ1
Lee, DK1
Currie, GP1
Hall, IP1
Lima, JJ1
Lipworth, BJ2
Palmer, CN1
Lee, S1
Ismail, T1
Macgregor, DF1
Mukhopadhyay, S1
Oppenheimer, J1
Nelson, HS1
Umeda, N1
Yoshikawa, T1
Kanazawa, H1
Hirata, K1
Fujimoto, S1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Beta-2 Adrenergic Polymorphisms on the Bronchoprotective Effects of Regular Salmeterol Treatment in Asthma[NCT00595361]30 participants (Actual)Interventional2008-01-31Completed
A Proof-of-concept Study to Evaluate the Benefit From add-on Therapy With Montelukast Versus Salmeterol in Children With Asthma Carrying the Arg/Arg-16 beta2-receptor Genotype[NCT00655616]64 participants (Actual)Interventional2007-08-31Completed
Prescribing Asthma Controller Medication According to Gene Status to Improve Quality of Life in Young People With Asthma[NCT02758873]241 participants (Actual)Interventional2016-02-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Comparison of the Maximum Percent Fall in FEV1 After 1st Dose of Salmeterol to the End of the 2-week Treatment Period Between Arg/Arg and Gly/Gly Subjects

(NCT00595361)
Timeframe: 2 weeks after 1st dose of Salmeterol

Intervention% fall FEV1 (Mean)
Arg/Arg-12.6
Gly/Gly-16.5

Comparison of the Maximum Percent Fall in FEV1 After Exercise Challenge at the End of the 2-week Treatment Period Between Arg/Arg and Gly/Gly Patients

(NCT00595361)
Timeframe: 2 weeks after exercise challenge

Intervention% fall FEV1 (Mean)
Arg/Arg12.6
Gly/Gly16.5

Comparison of the Maximum Percent Fall in FEV1 From Pre-salmeterol Baseline to the End of the 2-week Treatment Period Between Arg/Arg and Gly/Gly Patients

(NCT00595361)
Timeframe: 2 weeks from pre-salmeterol baseline

Intervention% fall FEV1 (Mean)
Arg/Arg5.9
Gly/Gly4.3

Reviews

3 reviews available for albuterol and Genetic Predisposition

ArticleYear
Mechanisms of asthma.
    The Journal of allergy and clinical immunology, 2003, Volume: 111, Issue:3 Suppl

    Topics: Adenine; Adult; Albuterol; Asthma; Bronchodilator Agents; Chemokines; Child; Cytokines; Disease Prog

2003
The arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol.
    British journal of clinical pharmacology, 2004, Volume: 57, Issue:1

    Topics: Albuterol; Asthma; Bronchodilator Agents; Double-Blind Method; Ethanolamines; Forced Expiratory Volu

2004
Safety of long-acting beta-agonists in asthma: a review.
    Current opinion in pulmonary medicine, 2008, Volume: 14, Issue:1

    Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adrenergic

2008

Trials

1 trial available for albuterol and Genetic Predisposition

ArticleYear
Association of beta2-adrenoreceptor genotypes with bronchodilatory effect of tiotropium in COPD.
    Respirology (Carlton, Vic.), 2008, Volume: 13, Issue:3

    Topics: Administration, Inhalation; Aged; Aged, 80 and over; Albuterol; Alleles; Bronchodilator Agents; Dose

2008

Other Studies

8 other studies available for albuterol and Genetic Predisposition

ArticleYear
Analysis of ADRB2 (Arg16Gly) Gene Variant with Susceptibility, Pharmacogenetic Response and Disease Severity in South Indian Asthmatics.
    Inflammation, 2015, Volume: 38, Issue:6

    Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Adult; Albuterol; Asthma; Bronchodi

2015
Is Gly16Arg β2 Receptor Polymorphism Related to Impulse Oscillometry in a Real-Life Asthma Clinic Setting?
    Lung, 2016, Volume: 194, Issue:2

    Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Air

2016
Genetic association analysis of COPD candidate genes with bronchodilator responsiveness.
    Respiratory medicine, 2009, Volume: 103, Issue:4

    Topics: Adult; Aged; Albuterol; Boston; Bronchodilator Agents; Female; Forced Expiratory Volume; Genetic Pre

2009
Successful use of albuterol in a patient with central core disease and mitochondrial dysfunction.
    Journal of inherited metabolic disease, 2010, Volume: 33 Suppl 3

    Topics: Activities of Daily Living; Adrenergic beta-2 Receptor Agonists; Albuterol; Child; Combined Modality

2010
Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma.
    American journal of respiratory cell and molecular biology, 2011, Volume: 44, Issue:6

    Topics: Adolescent; Adult; Aged; Albuterol; Asthma; Binding Sites; Bronchodilator Agents; Case-Control Studi

2011
Relationship between polymorphisms in the 5' leader cistron, positions 16 and 27 of the adrenergic β2 receptor gene and asthma in a Han population from southwest China.
    Respirology (Carlton, Vic.), 2011, Volume: 16, Issue:8

    Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Arginine; Asian People; Asthma; Bronchodilator Agent

2011
Beta2-adrenergic receptor polymorphisms as a determinant of preferential bronchodilator responses to β2-agonist and anticholinergic agents in Japanese patients with chronic obstructive pulmonary disease.
    Pharmacogenetics and genomics, 2011, Volume: 21, Issue:11

    Topics: Adrenergic beta-2 Receptor Agonists; Aged; Albuterol; Asian People; Bronchodilator Agents; Cholinerg

2011
Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol.
    Thorax, 2006, Volume: 61, Issue:11

    Topics: Adolescent; Adrenergic beta-Agonists; Albuterol; Arginine; Asthma; Child; Cross-Sectional Studies; F

2006
Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol.
    Thorax, 2006, Volume: 61, Issue:11

    Topics: Adolescent; Adrenergic beta-Agonists; Albuterol; Arginine; Asthma; Child; Cross-Sectional Studies; F

2006
Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol.
    Thorax, 2006, Volume: 61, Issue:11

    Topics: Adolescent; Adrenergic beta-Agonists; Albuterol; Arginine; Asthma; Child; Cross-Sectional Studies; F

2006
Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol.
    Thorax, 2006, Volume: 61, Issue:11

    Topics: Adolescent; Adrenergic beta-Agonists; Albuterol; Arginine; Asthma; Child; Cross-Sectional Studies; F

2006
Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol.
    Thorax, 2006, Volume: 61, Issue:11

    Topics: Adolescent; Adrenergic beta-Agonists; Albuterol; Arginine; Asthma; Child; Cross-Sectional Studies; F

2006
Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol.
    Thorax, 2006, Volume: 61, Issue:11

    Topics: Adolescent; Adrenergic beta-Agonists; Albuterol; Arginine; Asthma; Child; Cross-Sectional Studies; F

2006
Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol.
    Thorax, 2006, Volume: 61, Issue:11

    Topics: Adolescent; Adrenergic beta-Agonists; Albuterol; Arginine; Asthma; Child; Cross-Sectional Studies; F

2006
Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol.
    Thorax, 2006, Volume: 61, Issue:11

    Topics: Adolescent; Adrenergic beta-Agonists; Albuterol; Arginine; Asthma; Child; Cross-Sectional Studies; F

2006
Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol.
    Thorax, 2006, Volume: 61, Issue:11

    Topics: Adolescent; Adrenergic beta-Agonists; Albuterol; Arginine; Asthma; Child; Cross-Sectional Studies; F

2006