albuterol has been researched along with Disease, Pulmonary in 34 studies
Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, we examined the performance of the 6-min walk test, a rating of dyspnea following the walk test, and three different questionnaires measuring dyspnea in daily activities, in a controlled trial of inhaled salbutamol and oral theophylline in 24 patients with primary fixed chronic airflow limitation." | 5.07 | Measuring functional status in chronic lung disease: conclusions from a randomized control trial. ( Guyatt, GH; Keller, J; Nogradi, S; Singer, J; Townsend, M, 1991) |
| "Various lung diseases are associated with local activation of coagulation and concurrent inhibition of fibrinolysis." | 2.73 | Salmeterol enhances pulmonary fibrinolysis in healthy volunteers. ( Bresser, P; de Vos, AF; Jansen, HM; Levi, M; Maris, NA; van der Poll, T; van der Zee, JS, 2007) |
| "The clinicians followed various respiratory trends monitored by the Servo-i ventilator after albuterol dosing to document the clinical utility of using albuterol in this infant." | 1.42 | Assessing the Response to Inhaled Albuterol by Monitoring Patient Effort-Related Trends With a Servo-I Ventilator in Neurally Adjusted Ventilatory Assist Mode: A Case Presentation. ( Brinck, MJ; Snow, TM, 2015) |
| "Theophylline was the drug most involved in ADRs (53." | 1.32 | Retrospective analysis of adverse drug reactions to bronchodilators observed in two pulmonary divisions of Catanzaro, Italy. ( Colosimo, M; De Sarro, GB; Ferreri, G; Flocco, MA; Gallelli, L; Maselli, R; Pelaia, G; Pirritano, D, 2003) |
| " The new device, Airmax, uses proprietary technologies known as the X-ACT system to provide accurate and consistent dosing and excellent lung deposition--even at low inspiratory flow rates--combined with ease of use by the patient." | 1.31 | Delivery of salbutamol and of budesonide from a novel multi-dose inhaler Airmax. ( Colledge, J; Jones, S; O'Leary, D; Phelan, M; Zeng, XM, 2002) |
| "Albuterol was collected on a filter at the distal end of the ET tube and was quantitatively analyzed by high performance liquid chromatography." | 1.31 | Albuterol delivery in a neonatal ventilated lung model: Nebulization versus chlorofluorocarbon- and hydrofluoroalkane-pressurized metered dose inhalers. ( Ballard, J; Keenan, J; Kenney, JK; Lugo, RA; Salyer, JW; Ward, RM, 2001) |
| "Childhood pneumonia is associated with reduced ventilatory function in adults." | 1.30 | Effect of pneumonia and whooping cough in childhood on adult lung function. ( Anderson, HR; Johnston, ID; Strachan, DP, 1998) |
| "Retroperitoneal aortoiliac aneurysm repair was performed." | 1.30 | Awake aortic aneurysm repair in patients with severe pulmonary disease. ( Hirko, MK; Koler, AJ; Labat, GC; McGregor, WE; Perni, V; Rubin, JR, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (11.76) | 18.7374 |
| 1990's | 15 (44.12) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 7 (20.59) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ong, HX | 1 |
| Traini, D | 1 |
| Ballerin, G | 1 |
| Morgan, L | 1 |
| Buddle, L | 1 |
| Scalia, S | 1 |
| Young, PM | 1 |
| Snow, TM | 1 |
| Brinck, MJ | 1 |
| Sanders, M | 1 |
| Bruin, R | 1 |
| Ng, G | 2 |
| da Silva, O | 2 |
| Ohlsson, A | 2 |
| Bar-Yishay, E | 1 |
| Matyashchuk, E | 1 |
| Mussaffi, H | 1 |
| Mei-Zahav, M | 1 |
| Prais, D | 1 |
| Hananya, S | 1 |
| Steuer, G | 1 |
| Blau, H | 1 |
| Joshi, S | 1 |
| Powell, T | 1 |
| Watkins, WJ | 1 |
| Drayton, M | 1 |
| Williams, EM | 1 |
| Kotecha, S | 1 |
| Calogero, C | 1 |
| Simpson, SJ | 1 |
| Lombardi, E | 1 |
| Parri, N | 1 |
| Cuomo, B | 1 |
| Palumbo, M | 1 |
| de Martino, M | 1 |
| Shackleton, C | 1 |
| Verheggen, M | 1 |
| Gavidia, T | 1 |
| Franklin, PJ | 1 |
| Kusel, MM | 1 |
| Park, J | 1 |
| Sly, PD | 1 |
| Hall, GL | 1 |
| Zeng, XM | 1 |
| O'Leary, D | 1 |
| Phelan, M | 1 |
| Jones, S | 1 |
| Colledge, J | 1 |
| Gallelli, L | 1 |
| Ferreri, G | 1 |
| Colosimo, M | 1 |
| Pirritano, D | 1 |
| Flocco, MA | 1 |
| Pelaia, G | 1 |
| Maselli, R | 1 |
| De Sarro, GB | 1 |
| Maris, NA | 1 |
| de Vos, AF | 1 |
| Bresser, P | 1 |
| van der Zee, JS | 1 |
| Jansen, HM | 1 |
| Levi, M | 1 |
| van der Poll, T | 1 |
| Ferrada, MA | 1 |
| Gordon, EL | 1 |
| Jen, KY | 1 |
| He, HZ | 1 |
| Lu, X | 1 |
| Barone, LM | 1 |
| Amirifeli, S | 1 |
| Perkins, DL | 1 |
| Finn, PW | 1 |
| Boskabady, MH | 1 |
| Attaran, D | 1 |
| Shaffei, MN | 1 |
| Isakoff, MS | 1 |
| Lillo, JA | 1 |
| Hagstrom, JN | 1 |
| Krzywiecki, A | 1 |
| Ziora, D | 1 |
| Oklek, K | 1 |
| Niepsuj, G | 1 |
| Kozielski, J | 1 |
| Polońska, A | 1 |
| Dilworth, JP | 1 |
| Warley, AR | 1 |
| Dawe, C | 1 |
| White, RJ | 1 |
| O'Donnell, M | 1 |
| Garippa, RJ | 1 |
| Rinaldi, N | 1 |
| Selig, WM | 1 |
| Tocker, JE | 1 |
| Tannu, SA | 1 |
| Wasserman, MA | 1 |
| Welton, A | 1 |
| Bolin, DR | 1 |
| Yuksel, B | 1 |
| Greenough, A | 1 |
| Pfenninger, J | 1 |
| Aebi, C | 1 |
| Tal, A | 1 |
| Golan, H | 1 |
| Grauer, N | 1 |
| Aviram, M | 1 |
| Albin, D | 1 |
| Quastel, MR | 1 |
| McPeck, M | 1 |
| Tandon, R | 1 |
| Hughes, K | 1 |
| Smaldone, GC | 1 |
| Muñoz-Rodríguez, FJ | 1 |
| Font, J | 1 |
| Badia, JR | 1 |
| Miret, C | 1 |
| Barberà, JA | 1 |
| Cervera, R | 1 |
| Ingelmo, M | 1 |
| Gappa, M | 1 |
| Gärtner, M | 1 |
| Poets, CF | 1 |
| von der Hardt, H | 1 |
| Johnston, ID | 1 |
| Strachan, DP | 1 |
| Anderson, HR | 1 |
| Teper, AM | 1 |
| Kofman, CD | 1 |
| Maffey, AF | 1 |
| Vidaurreta, SM | 1 |
| McGregor, WE | 1 |
| Koler, AJ | 1 |
| Labat, GC | 1 |
| Perni, V | 1 |
| Hirko, MK | 1 |
| Rubin, JR | 1 |
| Lugo, RA | 1 |
| Kenney, JK | 1 |
| Keenan, J | 1 |
| Salyer, JW | 1 |
| Ballard, J | 1 |
| Ward, RM | 1 |
| Martin, S | 1 |
| Tuttle, CB | 1 |
| Sidorov, J | 1 |
| Chinn, DJ | 1 |
| Harkawat, R | 1 |
| Cotes, JE | 1 |
| Guyatt, GH | 1 |
| Townsend, M | 1 |
| Keller, J | 1 |
| Singer, J | 1 |
| Nogradi, S | 1 |
| Handelsman, E | 1 |
| Voulalas, D | 1 |
| Petring, OU | 1 |
| Adelhøj, B | 1 |
| Isawa, T | 1 |
| Teshima, T | 1 |
| Hirano, T | 1 |
| Ebina, A | 1 |
| Konno, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Albuterol Dose-Response on Pulmonary Function Testing in Preterm Infants at Risk of Bronchopulmonary Dysplasia[NCT02447250] | Phase 4 | 14 participants (Actual) | Interventional | 2013-10-24 | Completed | ||
| Within-Breath Total Respiratory Input Impedance in Healthy Adult Subjects[NCT04140825] | 231 participants (Actual) | Observational | 2018-10-18 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mothers who smoked cigarettes during pregnancy and the rate of albuterol response of their infants (NCT02447250)
Timeframe: Smoking and second hand smoke exposure history will be obtained at enrollment. Albuterol response will be obtained within one week.
| Intervention | participants (Number) | |
|---|---|---|
| albuterol responders of mothers who smoked | albuterol responders of non-smoker mothers % | |
| Single Arm: Varied Albuterol Dose Response | 4 | 6 |
birth weight in grams of each subject was recorded at time of enrollment (NCT02447250)
Timeframe: within one week of entering study
| Intervention | grams (Mean) | |
|---|---|---|
| albuterol responders | albuterol non responders | |
| Single Arm: Varied Albuterol Dose Response | 847.2 | 1147.7 |
The primary outcome is the percentage of subjects who show a positive response to each dose of albuterol. A positive response is defined as a greater than or equal to 10% decrease in respiratory resistance (Rrs). The change in RRs was measured at baseline and again after each dose of albuterol. All measurements were taken within a 7 day time frame for each subject such that each subject would have up to 3 results measured during a 7 day period, if he/she were able to complete three sets of PFTs according to study protocol. The change in Rrs was calculated by subtracting the baseline Rrs from the post-albuterol Rrs. (NCT02447250)
Timeframe: Within one week of performing pulmonary function tests
| Intervention | cm h2o/mL/sec (Mean) | ||
|---|---|---|---|
| dose 1 | dose 2 | dose 3 | |
| Single Arm: Varied Albuterol Dose Response | 0.011 | 0.006 | 0.014 |
Reason for each subject's preterm delivery was classified as either preterm labor or delivery for maternal indications (eg pre-eclampsia). (NCT02447250)
Timeframe: within one week of entering study
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| preterm labor, responsive to albuterol | maternal indicated delivery, responsive to albuter | |
| Single Arm: Varied Albuterol Dose Response | 4 | 6 |
Family history was obtained from verbal history by subject's mother at time of enrollment in study. A positive family history was noted if a first degree relative of the subject (infant) had a diagnosis of asthma. (NCT02447250)
Timeframe: History collected at enrollment, albuterol response assessed within one week
| Intervention | participants (Number) | |
|---|---|---|
| family hx of asthma, respond to albuterol | no fam hx asthma, respond to albuterol | |
| Single Arm: Varied Albuterol Dose Response | 1 | 9 |
Average gestational age (GA) in weeks at birth for subjects who responded to albuterol versus subjects without a positive response (NCT02447250)
Timeframe: within one week of entering study
| Intervention | weeks (Mean) | |
|---|---|---|
| birth GA albuterol responders, weeks | birth GA albuterol non responders | |
| Single Arm: Varied Albuterol Dose Response | 26.7 | 28.5 |
Maternal BMI will be obtained from her medial record, and she will be asked about weight gain during pregnancy at time of enrollment. Results will be compared for infants born to women with a normal BMI vs. those with obese BMI (>30). (NCT02447250)
Timeframe: Maternal information collected at enrollment; albuterol response assessed within one week
| Intervention | kg/m^2 (Mean) | |
|---|---|---|
| mean BMI mothers of albuterol-responders , any dos | mean BMI mothers of albuterol non-responders | |
| Single Arm: Varied Albuterol Dose Response | 27.4 | 27.3 |
Compare number of subjects who have a positive response (greater than or equal to 10% decrease in respiratory resistance) to each dose of albuterol (NCT02447250)
Timeframe: Data collected 15 minutes after dose in each session. Study includes 3 sessions within a 7 day period.
| Intervention | participants (Number) | ||
|---|---|---|---|
| positive Rrs response at 180 mcg albuterol | positive Rrs response at 270 mcg albuterol | positive Rrs response at 360 mcg albuterol | |
| Single Arm: Varied Albuterol Dose Response | 6 | 4 | 4 |
3 reviews available for albuterol and Disease, Pulmonary
| Article | Year |
|---|---|
A Rationale for Going Back to the Future: Use of Disposable Spacers for Pressurised Metered Dose Inhalers.
Topics: Administration, Inhalation; Albuterol; Bronchodilator Agents; Equipment Design; Humans; Inhalation S | 2015 |
Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants.
Topics: Albuterol; Aminophylline; Beclomethasone; Bronchodilator Agents; Chronic Disease; Drug Therapy, Comb | 2016 |
Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants.
Topics: Albuterol; Beclomethasone; Bronchodilator Agents; Chronic Disease; Humans; Infant, Newborn; Infant, | 2012 |
9 trials available for albuterol and Disease, Pulmonary
| Article | Year |
|---|---|
Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years.
Topics: Adolescent; Airway Resistance; Albuterol; Australia; Bronchi; Bronchodilator Agents; Child; Child, P | 2013 |
Salmeterol enhances pulmonary fibrinolysis in healthy volunteers.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Analysis of Variance; Bronch | 2007 |
Airway responses to salbutamol after exposure to chemical warfare.
Topics: Adult; Albuterol; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Chemical Warfare Agen | 2008 |
[Effect of salbutamol inhalation on small airways function in patients with sarcoidosis].
Topics: Administration, Inhalation; Adult; Albuterol; Bronchodilator Agents; Female; Forced Expiratory Volum | 1995 |
The effect of nebulized salbutamol therapy on the incidence of postoperative chest infection in high risk patients.
Topics: Aged; Albuterol; Double-Blind Method; Female; Humans; Lung Diseases; Male; Middle Aged; Nebulizers a | 1994 |
Respiratory response to salbutamol (albuterol) in ventilator-dependent infants with chronic lung disease: pressurized aerosol delivery versus intravenous injection.
Topics: Administration, Inhalation; Aerosols; Albuterol; Blood Gas Analysis; Blood Gas Monitoring, Transcuta | 1993 |
Effects of salbutamol delivery from a metered dose inhaler versus jet nebulizer on dynamic lung mechanics in very preterm infants with chronic lung disease.
Topics: Administration, Inhalation; Albuterol; Bronchodilator Agents; Chronic Disease; Cross-Over Studies; F | 1997 |
Lung function in infants with chronic pulmonary disease after severe adenoviral illness.
Topics: Adenoviridae Infections; Albuterol; Bronchodilator Agents; Child, Preschool; Chronic Disease; Humans | 1999 |
Measuring functional status in chronic lung disease: conclusions from a randomized control trial.
Topics: Aged; Albuterol; Chronic Disease; Double-Blind Method; Dyspnea; Exercise Test; Female; Humans; Lung; | 1991 |
22 other studies available for albuterol and Disease, Pulmonary
| Article | Year |
|---|---|
Combined inhaled salbutamol and mannitol therapy for mucus hyper-secretion in pulmonary diseases.
Topics: Administration, Inhalation; Albuterol; Bronchodilator Agents; Cells, Cultured; Cilia; Drug Therapy, | 2014 |
Assessing the Response to Inhaled Albuterol by Monitoring Patient Effort-Related Trends With a Servo-I Ventilator in Neurally Adjusted Ventilatory Assist Mode: A Case Presentation.
Topics: Administration, Inhalation; Albuterol; Bronchodilator Agents; Chronic Disease; Female; Humans; Infan | 2015 |
Use of the forced oscillation technique to detect bronchodilation in children: experience from the Schneider Children's Medical Center of Israel.
Topics: Adolescent; Age Factors; Albuterol; Bronchial Diseases; Bronchodilator Agents; Child; Child, Prescho | 2009 |
Exercise-induced bronchoconstriction in school-aged children who had chronic lung disease in infancy.
Topics: Albuterol; Asthma, Exercise-Induced; Bronchoconstriction; Bronchodilator Agents; Child; Exercise; Fe | 2013 |
Delivery of salbutamol and of budesonide from a novel multi-dose inhaler Airmax.
Topics: Administration, Inhalation; Albuterol; Bronchodilator Agents; Budesonide; Equipment Design; Humans; | 2002 |
Retrospective analysis of adverse drug reactions to bronchodilators observed in two pulmonary divisions of Catanzaro, Italy.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Albuterol; Beclomethasone; Bronchodilator Agent | 2003 |
(R)-albuterol decreases immune responses: role of activated T cells.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Cell Line; Cells, Cultured; Disease Models, Animal; Eo | 2008 |
A single-institution experience with treatment of severe acute chest syndrome: lack of rebound pain with dexamethasone plus transfusion therapy.
Topics: Adolescent; Albuterol; Anemia, Sickle Cell; Bronchodilator Agents; Child, Preschool; Fever; Humans; | 2008 |
Ro 25-1553: a novel, long-acting vasoactive intestinal peptide agonist. Part II: Effect on in vitro and in vivo models of pulmonary anaphylaxis.
Topics: Albuterol; Anaphylaxis; Animals; Antigens; Asthma; Bronchoalveolar Lavage Fluid; Bronchodilator Agen | 1994 |
Airways resistance and lung volume before and after bronchodilator therapy in symptomatic preterm infants.
Topics: Airway Resistance; Albuterol; Humans; Infant; Infant, Newborn; Infant, Premature; Lung; Lung Disease | 1994 |
Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Child, Preschool; Drug Deliv | 1996 |
Aerosol delivery during continuous nebulization.
Topics: Adrenergic beta-Agonists; Adult; Aerosols; Albuterol; Child; Cost Control; Equipment Design; Filtrat | 1997 |
Shrinking lungs syndrome in systemic lupus erythematosus: improvement with inhaled beta-agonist therapy.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Bronchodilator Agents; Femal | 1997 |
Effect of pneumonia and whooping cough in childhood on adult lung function.
Topics: Adult; Albuterol; Asthma; Child; Child, Preschool; Cohort Studies; Female; Forced Expiratory Volume; | 1998 |
Awake aortic aneurysm repair in patients with severe pulmonary disease.
Topics: Administration, Inhalation; Aged; Albuterol; Anesthesia, Epidural; Anesthesia, General; Anesthesia, | 1999 |
Albuterol delivery in a neonatal ventilated lung model: Nebulization versus chlorofluorocarbon- and hydrofluoroalkane-pressurized metered dose inhalers.
Topics: Administration, Inhalation; Albuterol; Bronchodilator Agents; Chlorofluorocarbons; Drug Delivery Sys | 2001 |
Pharmaceutical review: salbutamol - madopar - isocal.
Topics: Albuterol; Australia; Benserazide; Humans; Hydrazines; Levodopa; Lung Diseases; Parenteral Nutrition | 1978 |
Correct use of aerosol inhalers.
Topics: Aerosols; Albuterol; Asthma; Bronchodilator Agents; Humans; Lung Diseases; Methods | 1977 |
Standardization of single-breath transfer factor (TLCO); derivation of breathholding time.
Topics: Albuterol; Female; Humans; Lung Diseases; Male; Middle Aged; Pulmonary Diffusing Capacity; Reproduci | 1992 |
Albuterol inhalations in acute chest syndrome.
Topics: Acute Disease; Aerosols; Albuterol; Anemia, Sickle Cell; Child; Humans; Lung Diseases; Male; Respira | 1991 |
Preventing postoperative pulmonary complications.
Topics: Albuterol; Humans; Lung Diseases; Postoperative Complications | 1985 |
Effect of oral salbutamol on mucociliary clearance mechanisms in the lungs.
Topics: Adult; Aged; Albuterol; Cilia; Female; Humans; Lung; Lung Diseases; Lung Volume Measurements; Male; | 1986 |