Page last updated: 2024-10-22

albuterol and Critical Illness

albuterol has been researched along with Critical Illness in 10 studies

Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Critical Illness: A disease or state in which death is possible or imminent.

Research Excerpts

ExcerptRelevanceReference
"To compare the efficacy of theophylline, terbutaline, or theophylline combined with terbutaline treatment in critically ill children with status asthmaticus who are already receiving continuous nebulized albuterol and intravenous corticosteroids."9.11Theophylline versus terbutaline in treating critically ill children with status asthmaticus: a prospective, randomized, controlled trial. ( Bean, JA; Brilli, RJ; Hutson, TK; Jacobs, BR; Kenreigh, CA; Wheeler, DS, 2005)
"Data regarding the role of inhaled colistin in critically ill pediatric patients without cystic fibrosis are scarce."7.76Inhaled colistin for the treatment of tracheobronchitis and pneumonia in critically ill children without cystic fibrosis. ( Falagas, ME; Kafetzis, DA; Korbila, IP; Papadatos, JH; Sideri, G; Vouloumanou, EK, 2010)
"In critically ill adult patients, nebulized albuterol and ipratropium does not cause significant tachycardia or tachyarrhythmias."5.15Effects of nebulized bronchodilator therapy on heart rate and arrhythmias in critically ill adult patients. ( Barber, KR; Khorfan, FM; Smith, P; Watt, S, 2011)
"To compare the efficacy of theophylline, terbutaline, or theophylline combined with terbutaline treatment in critically ill children with status asthmaticus who are already receiving continuous nebulized albuterol and intravenous corticosteroids."5.11Theophylline versus terbutaline in treating critically ill children with status asthmaticus: a prospective, randomized, controlled trial. ( Bean, JA; Brilli, RJ; Hutson, TK; Jacobs, BR; Kenreigh, CA; Wheeler, DS, 2005)
" The majority of asthmatics were admitted to PICUs based on clinical asthma examination/score or because the patient was receiving continuous albuterol."3.79Corticosteroid therapy in critically ill pediatric asthmatic patients. ( Canarie, MF; Carroll, CL; Faustino, EV; Giuliano, JS; Li, S; Pinto, MG, 2013)
"Data regarding the role of inhaled colistin in critically ill pediatric patients without cystic fibrosis are scarce."3.76Inhaled colistin for the treatment of tracheobronchitis and pneumonia in critically ill children without cystic fibrosis. ( Falagas, ME; Kafetzis, DA; Korbila, IP; Papadatos, JH; Sideri, G; Vouloumanou, EK, 2010)
"In pediatric patients with respiratory failure, aerosolized albuterol increases functional residual capacity without a decrease in resistance."2.80Inhaled β2-Agonist Therapy Increases Functional Residual Capacity in Mechanically Ventilated Children With Respiratory Failure. ( Cornfield, DN; Henry, M; Milla, CE; Ramsi, MA, 2015)
"Albuterol was the most commonly used respiratory treatment, followed by chest physiotherapy, high-flow nasal cannula, and hypertonic saline."1.43A regional cohort study of the treatment of critically ill children with bronchiolitis. ( Canarie, MF; Carroll, CL; Faustino, EV; Giuliano, JS; Li, S; Pinto, MG; Sala, KA, 2016)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's8 (80.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jasiński, T1
Owczuk, R1
Wujtewicz, M1
Giuliano, JS2
Faustino, EV2
Li, S2
Pinto, MG2
Canarie, MF2
Carroll, CL2
Gedeit, RG1
Ramsi, MA1
Henry, M1
Milla, CE1
Cornfield, DN1
van der Hoeven, SM1
Binnekade, JM1
de Borgie, CA1
Bosch, FH1
Endeman, H1
Horn, J1
Juffermans, NP1
van der Meer, NJ1
Merkus, MP1
Moeniralam, HS1
van Silfhout, B1
Slabbekoorn, M1
Stilma, W1
Wijnhoven, JW1
Schultz, MJ1
Paulus, F1
Sala, KA1
Parmar, KK1
Dwaram, S1
Chacko, B1
Falagas, ME1
Sideri, G1
Korbila, IP1
Vouloumanou, EK1
Papadatos, JH1
Kafetzis, DA1
Khorfan, FM1
Smith, P1
Watt, S1
Barber, KR1
Wheeler, DS1
Jacobs, BR1
Kenreigh, CA1
Bean, JA1
Hutson, TK1
Brilli, RJ1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Development of Procedures to Optimalize the Intensive Care Units Patients Clinical Condition. Evaluation of Influence of Nebulized Bronchodilatory Drugs on Cardiac Repolarization[NCT01714401]50 participants (Actual)Interventional2012-03-31Completed
Effectiveness of Routine Nebulization of Mucolytics and Bronchodilators in Mechanically Ventilated Intensive Care Patients'[NCT02159196]950 participants (Actual)Interventional2014-07-31Completed
Prospective Trial of Effect of Nebulized Bronchodilators on Heart Rate and Arrhythmias in Critically Ill Adult Patients[NCT01151579]Phase 489 participants (Actual)Interventional2008-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Arrhythmias

Any new arrhythmia documented in the medical record that occurred between breathing treatments. (NCT01151579)
Timeframe: 15 minutes after each treatment for average of 3 to 5 days

Interventionpercent (Number)
Nebulized Albuterol 2.5mg0.33
Levalbuterol 1.251.3

Heart Rate in Beats Per Minute

Average difference in Heart rate between pre and post breathing treatments (NCT01151579)
Timeframe: Five days

Interventionbpm (Mean)
Nebulized Albuterol 2.5mg-0.16
Levalbuterol 1.251.40

Total Number of Participants With Arrhythmias

Documented new arrhythmia occurring during study. (NCT01151579)
Timeframe: Five days

Interventionparticipants (Number)
Nebulized Albuterol 2.5mg2
Levalbuterol 1.253

Trials

5 trials available for albuterol and Critical Illness

ArticleYear
The effect of nebulized salbutamol on atrial electrical properties in mechanically ventilated critically ill patients - a randomized, double-blind study.
    Anaesthesiology intensive therapy, 2018, Volume: 50, Issue:4

    Topics: Administration, Inhalation; Aged; Albuterol; Critical Illness; Double-Blind Method; Electrocardiogra

2018
Inhaled β2-Agonist Therapy Increases Functional Residual Capacity in Mechanically Ventilated Children With Respiratory Failure.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2015, Volume: 16, Issue:7

    Topics: Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Albuterol; Child; Child

2015
Preventive nebulization of mucolytic agents and bronchodilating drugs in invasively ventilated intensive care unit patients (NEBULAE): study protocol for a randomized controlled trial.
    Trials, 2015, Sep-02, Volume: 16

    Topics: Acetylcysteine; Administration, Inhalation; Albuterol; Bronchodilator Agents; Clinical Protocols; Co

2015
Effects of nebulized bronchodilator therapy on heart rate and arrhythmias in critically ill adult patients.
    Chest, 2011, Volume: 140, Issue:6

    Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Albuterol; Analysis of Variance; Arrhyth

2011
Theophylline versus terbutaline in treating critically ill children with status asthmaticus: a prospective, randomized, controlled trial.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2005, Volume: 6, Issue:2

    Topics: Adolescent; Albuterol; Bronchodilator Agents; Child; Child, Preschool; Critical Illness; Double-Blin

2005

Other Studies

5 other studies available for albuterol and Critical Illness

ArticleYear
Corticosteroid therapy in critically ill pediatric asthmatic patients.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2013, Volume: 14, Issue:5

    Topics: Administration, Intravenous; Adolescent; Adrenal Cortex Hormones; Adult; Albuterol; Asthma; Canada;

2013
Asthma, steroids, and surveys…science or merely my opinion?
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2013, Volume: 14, Issue:5

    Topics: Adrenal Cortex Hormones; Albuterol; Asthma; Critical Illness; Humans; Methylprednisolone; Practice P

2013
A regional cohort study of the treatment of critically ill children with bronchiolitis.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2016, Volume: 53, Issue:10

    Topics: Albuterol; Bronchiolitis; Bronchodilator Agents; Critical Illness; Female; Hospitals, Pediatric; Hum

2016
Mydriasis in a critically ill patient.
    Anaesthesia and intensive care, 2009, Volume: 37, Issue:5

    Topics: Albuterol; Anisocoria; Bronchodilator Agents; Critical Illness; Drug Therapy, Combination; Equipment

2009
Inhaled colistin for the treatment of tracheobronchitis and pneumonia in critically ill children without cystic fibrosis.
    Pediatric pulmonology, 2010, Volume: 45, Issue:11

    Topics: Acinetobacter baumannii; Acinetobacter Infections; Administration, Inhalation; Albuterol; Anti-Bacte

2010