albuterol and Bronchial Hyperreactivity studies

Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.

Research Excerpts

Excerpt	Relevance	Reference
"Low-dose salbutamol suppresses airway responsiveness to histamine but not methacholine in subjects with asthma."	9.17	Low-dose salbutamol suppresses airway responsiveness to histamine but not methacholine in subjects with asthma. ( Aizawa, H; Fukuyama, S; Inoue, H; Komori, M; Koto, H; Matsumoto, K; Takata, S; Yoshida, M, 2013)
"Therefore, we compared the effects of beclomethasone dipropionate (BDP) on the degree of BHR to inhaled histamine and NKA in a double-blind, controlled, cross-over study of asthmatic patients."	9.12	Beclomethasone dipropionate attenuates airways hyperresponsiveness to neurokinin A and histamine in asthma. ( Arcidiacono, G; Ciamarra, I; Crimi, N; Polosa, R; Prosperini, G, 2006)
"Twelve asthmatic patients were enrolled into a single-blind, placebo-controlled, crossover study, receiving additive therapy as either of the following: (1) montelukast alone, 10 mg (ML(10)); (2) inhaled salmeterol alone, 50 microg (SM(50)); (3) ML(10) and SM(50); (4) ML(10) and inhaled salmeterol, 100 microg (SM(100)); or (5) placebo inhaler and tablet."	9.09	Additive bronchoprotective and bronchodilator effects with single doses of salmeterol and montelukast in asthmatic patients receiving inhaled corticosteroids. ( Dempsey, OJ; Lipworth, BJ; Mistry, C; Sims, EJ; Wilson, AM, 2000)
"In volunteers with bronchial hyperreactivity, both lidocaine and salbutamol attenuate the response to an inhalational histamine challenge, and their combined administration has much greater effects than does either drug alone."	9.08	Combined intravenous lidocaine and inhaled salbutamol protect against bronchial hyperreactivity more effectively than lidocaine or salbutamol alone. ( Beste, M; Groeben, H; Peters, J; Silvanus, MT, 1998)
"Nedocromil sodium is recommended for daily treatment of mild persistent asthma but its effect on cellular changes in asthmatic airways is poorly understood."	9.08	Effect of regular nedocromil sodium or albuterol on bronchial inflammation in chronic asthma. ( Altraja, A; Laitinen, A; Laitinen, LA; Marran, S; Märtson, T; Meriste, S; Sillastu, H, 1996)
"In a double-blind, double-dummy, multicenter study, 212 patients with asthma whose symptoms were not controlled by as-needed use of inhaled bronchodilators were randomized to receive either 4 mg of nedocromil sodium or 180 micrograms of albuterol four times daily for 12 weeks."	9.08	Asthma symptoms and airway hyperresponsiveness are lower during treatment with nedocromil sodium than during treatment with regular inhaled albuterol. ( Findlay, SR; Furukawa, CT; Gross, GN; Henochowicz, SI; Hudson, LD; Marcoux, JP; Myers, DJ; Prenner, BM; Steinberg, P; Wasserman, SI, 1995)
"The effectiveness of maintenance albuterol aerosol therapy in cystic fibrosis (CF) was assessed by comparing spirometric measurements at the beginning and end of 1 year."	9.08	Short-term and long-term effects of albuterol aerosol therapy in cystic fibrosis: a preliminary report. ( Barbero, GJ; Gayer, D; König, P; Shaffer, J, 1995)
"In a double-blind, double-placebo, randomized crossover study, we compared the effects of 6 wk of treatment with the anti-inflammatory drug nedocromil sodium (16 mg/day) with 6 wk of treatment with the bronchodilator drug albuterol (800 micrograms/day) in 29 adults with allergic asthma."	9.07	Nedocromil sodium versus albuterol in the management of allergic asthma. ( de Jong, JW; de Monchy, JG; Koëter, GH; Postma, DS; Teengs, JP; van der Mark, TW, 1994)
"This study characterized a novel inhaled Btk inhibitor RN983 in vitro and in ovalbumin allergic mouse models of the early (EAR) and late (LAR) asthmatic response."	7.83	Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma. ( Bauer, CM; Burns, L; Harris, P; Laine, D; Peng, R; Phillips, JE; Renteria, L; Stevenson, CS, 2016)
" albuterol, are used for quick reversal of bronchoconstriction in asthmatics."	7.77	Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of β-receptor affinity in murine models of asthma. ( Aimi, S; Barone, LM; Bates, JH; Irvin, CG; Lundblad, LK; Poynter, ME; Riesenfeld, EP; Rinaldi, LM; Wu, M, 2011)
"(R)- and (S)-Enantiomers of albuterol likely exert differential effects in patients with asthma."	7.73	Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model. ( Banerjee, ER; Chi, EY; Henderson, WR, 2005)
"The effects of prednisolone, salbutamol or theophylline treatment were studied in guinea pigs on bronchial hyperreactivity induced by chronic administration of PAF, (subsequently measuring respiratory flow after an intravenous injection of histamine) and the chemokinesis of leucocytes in vitro."	7.68	Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs. ( Berga, P; Fernández, AG; Gristwood, RW; Llupiá, J, 1991)
" 12 patients received during a month salbutamol combined with nedocromil (Tilade 8 mg per day)."	6.67	[Bronchial hyperreactivity in patients with bronchial asthma treated with salbutamol and salbutamol combined with beclocort or nedocromil]. ( Krasnowska, M; Liebhart, E; Małolepszy, J, 1994)
"We examined the effects of two year's treatment of three inhaled beta 2-agonists (beta 2), such as salbutamol (S), procaterol (P) and fenoterol (F) on acetylcholine induced bronchial hyperresponsiveness (BHR) in mild approximately moderate asthmatics."	6.18	[Long-term effects of inhaled beta 2-agonists on bronchial hyperresponsiveness in asthmatics]. ( Ogawa, C; Sano, Y, 1996)
"Low-dose salbutamol suppresses airway responsiveness to histamine but not methacholine in subjects with asthma."	5.17	Low-dose salbutamol suppresses airway responsiveness to histamine but not methacholine in subjects with asthma. ( Aizawa, H; Fukuyama, S; Inoue, H; Komori, M; Koto, H; Matsumoto, K; Takata, S; Yoshida, M, 2013)
"Eighteen patients with mild allergic asthma who did not use any regular antiasthmatic therapy inhaled the long-acting beta(2)-agonist salmeterol for 2 weeks followed by 2 weeks of combination therapy with salmeterol and the corticosteroid fluticasone."	5.14	Adverse effects of salmeterol in asthma: a neuronal perspective. ( Bratke, K; Edner, A; Kuepper, M; Lindner, Y; Lommatzsch, M; Virchow, JC, 2009)
" Two groups followed a BHR treatment strategy (based on clinical parameters [lung function, asthma symptoms, and bronchodilator use] and BHR) and were treated with either fluticasone propionate/salmeterol (FSC(BHR) group) or fluticasone propionate (FP(BHR) group) (n=156 each)."	5.13	Does measuring BHR add to guideline derived clinical measures in determining treatment for patients with persistent asthma? ( Andersen, L; Dorinsky, P; Koenig, SM; Murray, JJ; Prillaman, B; Stauffer, J; Wolfe, J; Yancey, S, 2008)
"Therefore, we compared the effects of beclomethasone dipropionate (BDP) on the degree of BHR to inhaled histamine and NKA in a double-blind, controlled, cross-over study of asthmatic patients."	5.12	Beclomethasone dipropionate attenuates airways hyperresponsiveness to neurokinin A and histamine in asthma. ( Arcidiacono, G; Ciamarra, I; Crimi, N; Polosa, R; Prosperini, G, 2006)
" Subjects recorded asthma-related symptoms, morning and evening peak expiratory flow (PEF) levels, and use of supplemental albuterol daily on diary cards."	5.09	Effect of long-term salmeterol therapy compared with as-needed albuterol use on airway hyperresponsiveness. ( Baker, JW; Busse, WW; Emmett, A; Kalberg, C; Kemp, JP; Rickard, KA; Rosenthal, RR, 1999)
"These data demonstrate that asthma duration is associated with lower lung function, greater methacholine responsiveness, more asthma symptomatology, and greater use of as-needed albuterol, which are all measures of asthma severity."	5.09	Relationships between duration of asthma and asthma severity among children in the Childhood Asthma Management Program (CAMP) ( Dawson, C; Weiss, S; Zeiger, RS, 1999)
"Twelve asthmatic patients were enrolled into a single-blind, placebo-controlled, crossover study, receiving additive therapy as either of the following: (1) montelukast alone, 10 mg (ML(10)); (2) inhaled salmeterol alone, 50 microg (SM(50)); (3) ML(10) and SM(50); (4) ML(10) and inhaled salmeterol, 100 microg (SM(100)); or (5) placebo inhaler and tablet."	5.09	Additive bronchoprotective and bronchodilator effects with single doses of salmeterol and montelukast in asthmatic patients receiving inhaled corticosteroids. ( Dempsey, OJ; Lipworth, BJ; Mistry, C; Sims, EJ; Wilson, AM, 2000)
"Lidocaine inhalation, in subjects with bronchial hyperreactivity, attenuates evoked bronchoconstriction but also irritates airways."	5.09	Combined lidocaine and salbutamol inhalation for airway anesthesia markedly protects against reflex bronchoconstriction. ( Beste, M; Groeben, H; Peters, J; Silvanus, MT, 2000)
"The effectiveness of maintenance albuterol aerosol therapy in cystic fibrosis (CF) was assessed by comparing spirometric measurements at the beginning and end of 1 year."	5.08	Short-term and long-term effects of albuterol aerosol therapy in cystic fibrosis: a preliminary report. ( Barbero, GJ; Gayer, D; König, P; Shaffer, J, 1995)
"In volunteers with bronchial hyperreactivity, both lidocaine and salbutamol attenuate the response to an inhalational histamine challenge, and their combined administration has much greater effects than does either drug alone."	5.08	Combined intravenous lidocaine and inhaled salbutamol protect against bronchial hyperreactivity more effectively than lidocaine or salbutamol alone. ( Beste, M; Groeben, H; Peters, J; Silvanus, MT, 1998)
" The aim of the study was to determine the carbachol and albuterol responsiveness in treated and untreated asthmatic and allergic children exposed to environmental tobacco smoke assessed by urinary cotinine measurements."	5.08	Possible interaction between exposure to environmental tobacco smoke and therapy in children with asthma. ( Badier, M; Bruguerolle, B; Dubus, JC; Guillot, C; Oddoze, C, 1998)
"Nedocromil sodium is recommended for daily treatment of mild persistent asthma but its effect on cellular changes in asthmatic airways is poorly understood."	5.08	Effect of regular nedocromil sodium or albuterol on bronchial inflammation in chronic asthma. ( Altraja, A; Laitinen, A; Laitinen, LA; Marran, S; Märtson, T; Meriste, S; Sillastu, H, 1996)
"In a double-blind, double-dummy, multicenter study, 212 patients with asthma whose symptoms were not controlled by as-needed use of inhaled bronchodilators were randomized to receive either 4 mg of nedocromil sodium or 180 micrograms of albuterol four times daily for 12 weeks."	5.08	Asthma symptoms and airway hyperresponsiveness are lower during treatment with nedocromil sodium than during treatment with regular inhaled albuterol. ( Findlay, SR; Furukawa, CT; Gross, GN; Henochowicz, SI; Hudson, LD; Marcoux, JP; Myers, DJ; Prenner, BM; Steinberg, P; Wasserman, SI, 1995)
"In a double-blind, double-placebo, randomized crossover study, we compared the effects of 6 wk of treatment with the anti-inflammatory drug nedocromil sodium (16 mg/day) with 6 wk of treatment with the bronchodilator drug albuterol (800 micrograms/day) in 29 adults with allergic asthma."	5.07	Nedocromil sodium versus albuterol in the management of allergic asthma. ( de Jong, JW; de Monchy, JG; Koëter, GH; Postma, DS; Teengs, JP; van der Mark, TW, 1994)
"This study characterized a novel inhaled Btk inhibitor RN983 in vitro and in ovalbumin allergic mouse models of the early (EAR) and late (LAR) asthmatic response."	3.83	Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma. ( Bauer, CM; Burns, L; Harris, P; Laine, D; Peng, R; Phillips, JE; Renteria, L; Stevenson, CS, 2016)
" albuterol, are used for quick reversal of bronchoconstriction in asthmatics."	3.77	Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of β-receptor affinity in murine models of asthma. ( Aimi, S; Barone, LM; Bates, JH; Irvin, CG; Lundblad, LK; Poynter, ME; Riesenfeld, EP; Rinaldi, LM; Wu, M, 2011)
"Airway responsiveness to histamine, diurnal peak-flow variability, and bronchodilator reversibility cannot be used interchangeably as objective markers of asthma in epidemiologic studies."	3.73	Recognition of asthma in adolescents and young adults: which objective measure is best? ( Backer, V; Postma, DS; Ulrik, CS, 2005)
"(R)- and (S)-Enantiomers of albuterol likely exert differential effects in patients with asthma."	3.73	Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model. ( Banerjee, ER; Chi, EY; Henderson, WR, 2005)
" We have investigated the effects of RP 73401, a novel, potent and highly selective cyclic nucleotide phosphodiesterase (PDE) type IV inhibitor, in guinea-pig and rat models of bronchoconstriction and allergic inflammation."	3.69	Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor. ( Battram, CH; Jordan, R; Lewis, SA; Raeburn, D; Sharma, S; Souness, JE; Tomkinson, A; Underwood, SL; Webber, SE; Woodman, VR, 1994)
"There was no relationship between the bronchial responsiveness to histamine and acetic acid cough threshold in these patients."	3.69	Relationship between the acid-induced cough response and airway responsiveness and obstruction in children with asthma. ( Mochizuki, H; Morikawa, A; Shimizu, T; Tokuyama, K, 1996)
"In guinea pigs passively sensitized to ovalbumin, sustained (6 days) subcutaneous infusion of (+/-)salbutamol (1 mg/kg/day) induced significant airway obstruction and heightened responsivity to airway spasmogens."	3.68	Exacerbation of airway hyperreactivity by (+/-)salbutamol in sensitized guinea pig. ( Hoshiko, K; Morley, J, 1993)
"A 40-yr-old woman with severe chronic asthma complained that her regular nebulized albuterol was exacerbating her symptoms."	3.68	Paradoxical bronchoconstriction with nebulized albuterol but not with terbutaline. ( Finnerty, JP; Howarth, PH, 1993)
"The effects of prednisolone, salbutamol or theophylline treatment were studied in guinea pigs on bronchial hyperreactivity induced by chronic administration of PAF, (subsequently measuring respiratory flow after an intravenous injection of histamine) and the chemokinesis of leucocytes in vitro."	3.68	Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs. ( Berga, P; Fernández, AG; Gristwood, RW; Llupiá, J, 1991)
" Allergic bronchial eosinophilia in guinea pigs was inhibited by orally administered dexamethasone and methylprednisolone."	3.68	Allergic bronchial eosinophilia: a therapeutic approach for the selection of potential bronchial anti-inflammatory drugs. ( Chand, N; De Vine, CL; Diamantis, W; Harrison, JE; Jakubicki, RG; Nolan, KW; Pillar, J; Rooney, SM; Sofia, RD, 1993)
"We hypothesised that airway remodelling contributes to airway hyper-responsiveness in asthma, independent of steroid-responsive airway inflammation."	2.76	The effect of airway remodelling on airway hyper-responsiveness in asthma. ( Berend, N; Brown, NJ; Farah, CS; Hardaker, KM; Kermode, JA; King, GG; Salome, CM, 2011)
" For patients in group A, a fixed dosage was maintained for 18 months, while those in group B received tailored dosage or withdrawal of therapy according to the clinical control level (well or total control)."	2.73	[A clinical study on the significance of airway hyperresponsiveness monitoring in the adjustment of combined therapy for asthmatic patients]. ( Liu, CT; Pang, YM; Tan, CW; Wang, G; Wang, YM, 2007)
"Desloratadine is a potent antihistamine."	2.73	The effect of regular versus on-demand desloratadine treatment in children with allergic rhinitis. ( Adalioglu, G; Dizdar, EA; Dogan, C; Kalayci, O; Keskin, O; Sekerel, BE; Tuncer, A, 2007)
"Subjects quantified their sensation of breathlessness during the challenge tests on a modified Borg scale at the start of the study and every 4 weeks thereafter."	2.70	Potential masking effect on dyspnoea perception by short- and long-acting beta2-agonists in asthma. ( Bijl-Hofland, ID; Cloosterman, SG; Folgering, HT; van der Elshout, FJ; van Schayck, CP; Van Weel, C, 2002)
" PD20 FEV1 and dose-response slope [DRS; maximal change in FEV1 (%)/dose of Mch (mumol)] were used to evaluate efficacy."	2.69	The bronchoprotective efficacy of salbutamol inhaled from a new metered-dose powder inhaler compared with a conventional pressurized metered-dose inhaler connected to a spacer. ( Alanko, K; Hedman, J; Herrala, J; Liipo, K; Nieminen, MM; Nyholm, JE; Pietinalho, A; Seppälä, OP; Terho, E, 1998)
" 12 patients received during a month salbutamol combined with nedocromil (Tilade 8 mg per day)."	2.67	[Bronchial hyperreactivity in patients with bronchial asthma treated with salbutamol and salbutamol combined with beclocort or nedocromil]. ( Krasnowska, M; Liebhart, E; Małolepszy, J, 1994)
" After each period, dose-response curves were measured on 4 study days with doubling doses of salbutamol, ipratropium, a combination of salbutamol and ipratropium, and placebo until a plateau in FEV1 was reached."	2.67	Separate and combined effects of corticosteroids and bronchodilators on airflow obstruction and airway hyperresponsiveness in asthma. ( Alting-Hebing, D; Breederveld, N; Koëter, GH; Postma, DS; van der Mark, TW; Wempe, JB, 1992)
" There are also concerns with regard to the effects of LABAs on bronchial hyperresponsiveness (BHR), where long-term use is associated with increased BHR and loss of bronchoprotection."	2.58	Long-Acting β2-Agonists in Asthma: Enantioselective Safety Studies are Needed. ( Calzetta, L; Farber, MO; Hostrup, M; Jacobson, GA; Page, CP; Raidal, S; Walters, EH; Wood-Baker, R, 2018)
" Long-term use of long-acting beta(2)-agonists can induce tolerance, which can be partially reversed with corticosteroids."	2.41	Long-acting beta2-agonists: comparative pharmacology and clinical outcomes. ( Aalbers, R; van der Woude, HJ, 2002)
"In this study, we determined whether airway remodeling and hyperresponsiveness similar to asthma are evident in this model, and whether IL-1Ra is protective."	1.43	Airway Remodeling and Hyperreactivity in a Model of Bronchopulmonary Dysplasia and Their Modulation by IL-1 Receptor Antagonist. ( Bourke, JE; Bui, C; Donovan, C; Lam, M; Lamanna, E; Nold, MF; Nold-Petry, CA; Royce, SG; Rudloff, I, 2016)
") completely reversed the rightward shift of the formoterol dose-response curve due to beta(2)-receptor desensitisation."	1.34	Formoterol and beclomethasone dipropionate interact positively in antagonising bronchoconstriction and inflammation in the lung. ( Bergamaschi, M; Berti, F; Bolzoni, P; Civelli, M; Razzetti, R; Rossoni, G; Villetti, G, 2007)
"6 microgram/kg) and aminophylline (25 mg/kg), which were determined by the dose-response curves for inhibition of histamine-induced bronchoconstriction, were intravenously administered 5 minutes before the propranolol inhalation."	1.30	Difference in bronchoprotective effects of bronchodilators on postallergic propranolol-induced bronchoconstriction. ( Fujimura, M; Ishiura, Y; Matsuda, T; Mizuhashi, K; Myou, S, 1999)
" infusion of each agonist by constructing cumulative dose-response curves from breath-by-breath measurements of the effect of different rates of i."	1.29	Enhancement of airway reactivity to histamine by isoprenaline and related beta-adrenoceptor agonists in the guinea-pig. ( Blackman, JG; Galland, BC, 1993)
" In the 11 patients with complete dose-response curves, the geometric mean of diurnal PFV variation (% mean range) was 5."	1.29	[Relations between nonspecific bronchial hyperreactivity, diurnal variation of peak expiratory flow and medication requirements in patients with mild asthma]. ( Bertó, JM; Camps, B; Gutiérrez, V; Pérez, MJ; Prieto, L, 1994)
" Given orally, RP 58802B (5 mg/kg, 60 min before challenge) produced a greater than three-fold shift to the right of the dose-response curve and depressed the maximum response to histamine by 39 +/- 11%."	1.28	RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo. ( Lewis, SA; Raeburn, D; Underwood, SL, 1992)
"Marfan syndrome is known to have pulmonary manifestations such as pneumothorax."	1.28	Bronchial hyperreactivity in children with Marfan syndrome. ( Boxer, R; König, P; Morrison, J; Pletcher, B, 1991)

Research

Studies (165)

Authors

Clinical Trials (9)

Trial Overview

Trial Outcomes

Comparison of the Maximum Percent Fall in FEV1 After 1st Dose of Salmeterol to the End of the 2-week Treatment Period Between Arg/Arg and Gly/Gly Subjects

Comparison of the Maximum Percent Fall in FEV1 After Exercise Challenge at the End of the 2-week Treatment Period Between Arg/Arg and Gly/Gly Patients

Comparison of the Maximum Percent Fall in FEV1 From Pre-salmeterol Baseline to the End of the 2-week Treatment Period Between Arg/Arg and Gly/Gly Patients

Bronchial Responsiveness to Serial Methacholine Concentrations Inhaled Into the Lungs

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	89 (53.94)	18.2507
2000's	57 (34.55)	29.6817
2010's	19 (11.52)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Jacobson, GA	1
Raidal, S	1
Hostrup, M	1
Calzetta, L	1
Wood-Baker, R	1
Farber, MO	1
Page, CP	2
Walters, EH	1
Ravi, A	1
Chowdhury, S	1
Dijkhuis, A	1
Bonta, PI	1
Sterk, PJ	3
Lutter, R	1
Nuijsink, M	2
Hop, WC	3
Jongste, JC	1
Duiverman, AE	1
Anderson, WJ	1
Short, PM	1
Williamson, PA	1
Morrison, AE	1
Palmer, C	1
Tavendale, R	1
Lipworth, BJ	3
Matsumoto, K	2
Aizawa, H	2
Fukuyama, S	1
Yoshida, M	1
Komori, M	1
Takata, S	2
Koto, H	1
Inoue, H	2
Sun, X	1
Zhang, Y	1
Yang, W	1
Liu, J	1
Rinaldi, B	1
Capuano, A	1
Gritti, G	1
Donniacuo, M	1
Scotto Di Vettimo, A	1
Sodano, L	1
Rafaniello, C	1
Rossi, F	1
Matera, MG	1
Sharif, M	1
Khan, BT	1
Ajmal, K	1
Anwar, MA	1
Halfhide, C	2
Evans, HJ	2
Couriel, J	2
Phillips, JE	1
Renteria, L	1
Burns, L	1
Harris, P	1
Peng, R	1
Bauer, CM	1
Laine, D	1
Stevenson, CS	1
Royce, SG	1
Nold, MF	1
Bui, C	1
Donovan, C	1
Lam, M	1
Lamanna, E	1
Rudloff, I	1
Bourke, JE	1
Nold-Petry, CA	1
Fruchter, O	2
Yigla, M	2
Richie, RC	1
Miyagawa, N	1
Iwasaki, H	1
Kato, T	1
Tanaka, M	1
Shibata, T	1
Wakitani, K	1
Kramer, EL	1
Mushaben, EM	1
Pastura, PA	1
Acciani, TH	1
Deutsch, GH	1
Khurana Hershey, GK	1
Korfhagen, TR	1
Hardie, WD	1
Whitsett, JA	1
Le Cras, TD	1
Lommatzsch, M	1
Lindner, Y	1
Edner, A	1
Bratke, K	1
Kuepper, M	1
Virchow, JC	1
Townley, RG	1
Gendapodi, PR	1
Qutna, N	1
Evans, J	1
Romero, FA	1
Abel, P	1
Hardak, E	1
Page, C	1
Lundblad, LK	2
Rinaldi, LM	1
Poynter, ME	1
Riesenfeld, EP	1
Wu, M	1
Aimi, S	1
Barone, LM	1
Bates, JH	2
Irvin, CG	2
Araújo, L	1
Moreira, A	1
Palmares, C	1
Beltrão, M	1
Fonseca, J	1
Delgado, L	2
Ciprandi, G	1
Signori, A	1
Cirillo, I	1
Mendonça, NT	1
Kenyon, J	1
LaPrad, AS	1
Syeda, SN	1
O'Connor, GT	1
Lutchen, KR	1
Kermode, JA	1
Brown, NJ	1
Hardaker, KM	1
Farah, CS	1
Berend, N	1
King, GG	2
Salome, CM	2
Delescluse, I	1
Mace, H	1
Adcock, JJ	1
Machado, D	1
Pereira, C	1
Tavares, B	1
Loureiro, G	1
Segorbe-Luís, A	1
Trifilieff, A	1
Fozard, JR	2
Wolf, BL	1
Sjöswärd, KN	1
Josefsson, M	1
Ahlner, J	1
Schmekel, B	1
Marotta, A	1
Klinnert, MD	1
Price, MR	1
Larsen, GL	1
Liu, AH	1
van der Woude, HJ	1
Aalbers, R	1
Boskabady, MH	1
Saadatinejad, M	1
Fukkuda, T	1
Schütz, N	1
Peták, F	1
Barazzone-Argiroffo, C	1
Sly, PD	1
Habre, W	1
Halvorsen, T	1
Skadberg, BT	1
Eide, GE	1
Røksund, OD	1
Carlsen, KH	1
Bakke, P	1
Wallin, A	1
Pourazar, J	1
Sandström, T	1
Parker, AL	1
Currie, GP	1
Lee, DK	1
Westerhof, FJ	1
Zuidhof, AB	1
Kok, L	1
Meurs, H	1
Zaagsma, J	1
van den Toorn, LM	1
Prins, JB	1
de Jongste, JC	4
Leman, K	1
Mulder, PG	1
Hoogsteden, HC	1
Overbeek, SE	1
Futrakul, S	1
Deerojanawong, J	1
Prapphal, N	1
Henderson, WR	1
Banerjee, ER	1
Chi, EY	1
Nobata, K	1
Kurashima, K	1
Fujimura, M	3
Abo, M	1
Ishiura, Y	2
Kasahara, K	1
Nakao, S	1
Ulrik, CS	1
Postma, DS	4
Backer, V	1
Prosperini, G	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
A Proof of Concept Study to Evaluate the Trough Bronchoprotection Conferred by Chronic Dosing With Levosalbutamol and Racemic Salbutamol in Persistent Asthmatics[NCT00831376]	Phase 4	30 participants (Actual)	Interventional	2009-01-31	Completed
Effect of Salmeterol on Brain-Derived Neurotrophic Factor (BDNF) Concentrations in Asthma[NCT00736801]		35 participants (Actual)	Interventional	2005-09-30	Completed
Adjustment of Asthma Treatment in Children Based on an Indirect Hyperresponsiveness Test - a Randomized Trial[NCT04509921]		108 participants (Actual)	Interventional	2018-07-02	Completed
A Prospective, Open Label, Single-center Study of the Long-term Prognosis of Moderate to Severe Bronchial Hyperresponsiveness (BHR) in Asthmatic Preschool Children.[NCT01144910]		0 participants (Actual)	Observational	2011-05-31	Withdrawn (stopped due to Due to few capacities 2011 to 2016 the study was withdrawn.)
A Multicenter, Randomized, Double-blind, Parallel Group, 40-week Comparison of Asthma Control Using Bronchial Hyperresponsiveness as an Additional Guide to Long-term Treatment in Adolescents and Adults Receiving Either Fluticasone Propionate/Salmeterol DI[NCT00920543]	Phase 4	464 participants (Actual)	Interventional	2003-02-28	Completed
The Effect of Beta-2 Adrenergic Polymorphisms on the Bronchoprotective Effects of Regular Salmeterol Treatment in Asthma[NCT00595361]		30 participants (Actual)	Interventional	2008-01-31	Completed
Childhood Asthma Management Program[NCT00000575]	Phase 3	1,041 participants (Actual)	Interventional	1991-09-30	Completed
Is the Exhaled Nitric Oxide in Infants a Predictive Marker of Asthma?[NCT01239199]		86 participants (Actual)	Interventional	2010-01-31	Completed
[NCT00005537]		0 participants	Observational	1997-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	% fall FEV1 (Mean)
Arg/Arg	-12.6
Gly/Gly	-16.5

Intervention	% fall FEV1 (Mean)
Arg/Arg	12.6
Gly/Gly	16.5

Intervention	% fall FEV1 (Mean)
Arg/Arg	5.9
Gly/Gly	4.3

Bronchial responsiveness to serial concentrations of inhaled methacholine solution (mg/ml) as measured by serial ratios of follow-up to baseline FEV1 (forced volume of air expired from the lungs in one second). A dose-response curve is calculated from the serial ratios in relation to the serial concentrations to determine PC20, the concentration associated with a 20% drop from baseline in FEV1; this PC20 is the outcome measure with units mg/ml of methacholine. (NCT00000575)
Timeframe: 4-6 years from baseline

Change From Baseline in the Rate of Asthma Free Days

Intervention	mg/ml of methacholine (Geometric Mean)
1 Budesonide	3.0
2 Nedocromil	1.8
3 Placebo	1.9

Change from baseline proportion of days without asthma symptoms or other asthma related events to proportion of days during the 4-6 years of follow-up. Asthma free days were determined from daily asthma diaries kept from baseline to the end of treatment, 4-6 years later. (NCT00000575)
Timeframe: 4-6 years from baseline

Change in Height From Baseline to End of Treatment, 4-6 Years Later

Intervention	days per month (Mean)
1 Budesonide	11.3
2 Nedocromil	9.3
3 Placebo	9.3

Change in standing height from baseline to end of treatment. Standing height is measured three times without shoes using a calibrated Harpenden stadiometer; the average of the three repeated heights to the nearest 0.1 cm is the height measure at either baseline or end of treatment. (NCT00000575)
Timeframe: 4-6 years from baseline

Mortality

Need for Urgent Care for Asthma

Intervention	cm (Mean)
1 Budesonide	22.7
2 Nedocromil	23.7
3 Placebo	23.8

Intervention	participants (Number)
1 Budesonide	0
2 Nedocromil	1
3 Placebo	0

Counts during the period of treatment (4-6 years) of visits to emergency rooms or equivalent urgent care settings for asthma treatment. (NCT00000575)
Timeframe: 4-6 years from baseline

Pulmonary Function as Measured by Normalized FEV1 Over a 4-6 Year Period

Intervention	rate per 100 person years (Number)
1 Budesonide	12
2 Nedocromil	16
3 Placebo	22

Change in FEV1 % of predicted, post-bronchodilator use, from baseline to the end of treatment (4-6 years after randomization). Percent predicted determined from three separate published sets of reference equations for white, black, and Hispanic children - see NEJM 343: 1054-1062, 2000 for more details and references. (NCT00000575)
Timeframe: At the end of treatment, 4-6 years from baseline assessment

Standardized Depression Scale -- Children's Depression Inventory

Intervention	percentage of predicted value (Mean)
1 Budesonide	0.6
2 Nedocromil	-0.5
3 Placebo	-0.1

Change in total score on the Children's Depression Inventory from baseline to the end of treatment, 4-6 years later. The total score ranges from 0-54 with higher scores indicating greater levels of depression. (NCT00000575)
Timeframe: 4-6 years from baseline

Article	Year
Long-Acting β2-Agonists in Asthma: Enantioselective Safety Studies are Needed. Drug safety, 2018, Volume: 41, Issue:5 Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreacti	2018
WITHDRAWN: Inhaled bronchodilators for cystic fibrosis. The Cochrane database of systematic reviews, 2016, Feb-11, Volume: 2 Topics: Adrenergic beta-Agonists; Adult; Albuterol; Bronchial Hyperreactivity; Bronchodilator Agents; Child;	2016
Long-acting beta2-agonists: comparative pharmacology and clinical outcomes. American journal of respiratory medicine : drugs, devices, and other interventions, 2002, Volume: 1, Issue:1 Topics: Adrenergic beta-Agonists; Albuterol; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Do	2002
[Recent study on pathogenesis of bronchial asthma and the therapeutic strategy]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2004, Mar-10, Volume: 93, Issue:3 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Anti-Asthmatic Agents; Anti-Inflamm	2004
Inhaled bronchodilators for cystic fibrosis. The Cochrane database of systematic reviews, 2005, Oct-19, Issue:4 Topics: Adrenergic beta-Agonists; Adult; Albuterol; Bronchial Hyperreactivity; Bronchodilator Agents; Child;	2005
Levalbuterol for asthma: a better treatment? Current allergy and asthma reports, 2007, Volume: 7, Issue:4 Topics: Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents; Clinical Trials as Top	2007
Salmeterol: an inhaled beta 2-agonist with prolonged duration of action. Lung, 1993, Volume: 171, Issue:5 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Asthma; Bronchial Hyperreactivity;	1993
Anomalous effects of albuterol and other sympathomimetics in the guinea pig. Clinical reviews in allergy & immunology, 1996,Spring, Volume: 14, Issue:1 Topics: Albuterol; Animals; Bronchial Hyperreactivity; Drug Hypersensitivity; Guinea Pigs; Inflammation; Rec	1996
[Anti-allergic effects of beta-adrenoceptor agonists in the clinical pharmacological studies]. Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:11 Topics: Adrenergic beta-Agonists; Albuterol; Anti-Allergic Agents; Asthma; Bronchi; Bronchial Hyperreactivit	1996
[Long-term effects of inhaled beta 2-agonists on bronchial hyperresponsiveness in asthmatics]. Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:11 Topics: Administration, Oral; Adrenergic beta-Agonists; Albuterol; Asthma; Bronchial Hyperreactivity; Fenote	1996
Airway subsensitivity with long-acting beta 2-agonists. Is there cause for concern? Drug safety, 1997, Volume: 16, Issue:5 Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Albuterol; Asthma; Bronchial Hyperreactivity; Bro	1997
Association of sputum parameters with clinical and functional measurements in asthma. Thorax, 2000, Volume: 55, Issue:3 Topics: Albuterol; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Eosinophils; Forced Expirato	2000
Long-acting beta(2)-agonists in management of childhood asthma: A critical review of the literature. Pediatric pulmonology, 2000, Volume: 29, Issue:3 Topics: Administration, Topical; Adrenergic beta-Agonists; Albuterol; Anti-Inflammatory Agents; Asthma; Asth	2000
[Bronchodilator effect of salmeterol and inhibition of bronchial hyperreactivity]. Revue des maladies respiratoires, 1992, Volume: 9 Suppl 1 Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests;	1992
[Variety of pharmacological action of beta agonists]. Arerugi = [Allergy], 1992, Volume: 41, Issue:5 Topics: Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocati	1992
Pediatric pulmonary function testing in asthma. Pediatric clinics of North America, 1992, Volume: 39, Issue:6 Topics: Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Humans; Infant; Re	1992

Article	Year
Perception of bronchoconstriction: a complementary disease marker in children with asthma. The Journal of asthma : official journal of the Association for the Care of Asthma, 2013, Volume: 50, Issue:6 Topics: Adolescent; Albuterol; Androstadienes; Anti-Allergic Agents; Asthma; Bronchial Hyperreactivity; Bron	2013
Proof-of-concept evaluation of trough airway hyper-responsiveness following regular racemic or levosalbutamol in genotype-stratified steroid-treated persistent asthmatic patients. Clinical science (London, England : 1979), 2014, 01-01, Volume: 126, Issue:1 Topics: Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Albuterol;	2014
Low-dose salbutamol suppresses airway responsiveness to histamine but not methacholine in subjects with asthma. Respiratory investigation, 2013, Volume: 51, Issue:3 Topics: Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Albuterol;	2013
Comparison of capnovolumetry-derived dead space parameters with pulmonary function test in normal adults using histamine provocation. The clinical respiratory journal, 2015, Volume: 9, Issue:2 Topics: Adult; Albuterol; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Cap	2015
Adverse effects of salmeterol in asthma: a neuronal perspective. Thorax, 2009, Volume: 64, Issue:9 Topics: Adolescent; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Albuterol; Androst	2009
The response to bronchodilators in adults is not predictive of bronchial-hyperreactivity. The Journal of asthma : official journal of the Association for the Care of Asthma, 2009, Volume: 46, Issue:5 Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Bronchial Hyperreactivity; Bronchodilator	2009
The effect of airway remodelling on airway hyper-responsiveness in asthma. Respiratory medicine, 2011, Volume: 105, Issue:12 Topics: Adult; Airway Remodeling; Airway Resistance; Albuterol; Androstadienes; Asthma; Bronchial Hyperreact	2011
Airways hyperresponsiveness to different inhaled combination therapies in adolescent asthmatics. European annals of allergy and clinical immunology, 2012, Volume: 44, Issue:1 Topics: Adolescent; Albuterol; Androstadienes; Asthma; Asthma, Exercise-Induced; Bronchial Hyperreactivity;	2012
Preserved bronchial dilatation after salbutamol does not guarantee protection against bronchial hyperresponsiveness. Clinical physiology and functional imaging, 2003, Volume: 23, Issue:1 Topics: Adrenergic beta-Agonists; Adult; Airway Resistance; Albuterol; Asthma; Bronchi; Bronchial Hyperreact	2003
LPS-induced bronchoalveolar neutrophilia; effects of salmeterol treatment. Respiratory medicine, 2004, Volume: 98, Issue:11 Topics: Adrenergic beta-Agonists; Adult; Albuterol; Bronchial Hyperreactivity; Bronchial Provocation Tests;	2004
Benefit from anti-inflammatory treatment during clinical remission of atopic asthma. Respiratory medicine, 2005, Volume: 99, Issue:6 Topics: Adolescent; Adult; Albuterol; Analysis of Variance; Androstadienes; Anti-Asthmatic Agents; Anti-Infl	2005
Beclomethasone dipropionate attenuates airways hyperresponsiveness to neurokinin A and histamine in asthma. Respiratory medicine, 2006, Volume: 100, Issue:6 Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Albuterol; Ana	2006
The structural basis of airways hyperresponsiveness in asthma. Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 101, Issue:1 Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchoconstriction;	2006
The effect of regular versus on-demand desloratadine treatment in children with allergic rhinitis. International journal of pediatric otorhinolaryngology, 2007, Volume: 71, Issue:6 Topics: Adolescent; Albuterol; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents;	2007
Placebo response in asthma: a robust and objective phenomenon. The Journal of allergy and clinical immunology, 2007, Volume: 119, Issue:6 Topics: Adolescent; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Cross-Over Studies; Double-Blind Me	2007
Long-term asthma treatment guided by airway hyperresponsiveness in children: a randomised controlled trial. The European respiratory journal, 2007, Volume: 30, Issue:3 Topics: Administration, Inhalation; Adolescent; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Br	2007
Long-term asthma treatment guided by airway hyperresponsiveness in children: a randomised controlled trial. The European respiratory journal, 2007, Volume: 30, Issue:3 Topics: Administration, Inhalation; Adolescent; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Br	2007
Long-term asthma treatment guided by airway hyperresponsiveness in children: a randomised controlled trial. The European respiratory journal, 2007, Volume: 30, Issue:3 Topics: Administration, Inhalation; Adolescent; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Br	2007
Long-term asthma treatment guided by airway hyperresponsiveness in children: a randomised controlled trial. The European respiratory journal, 2007, Volume: 30, Issue:3 Topics: Administration, Inhalation; Adolescent; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Br	2007
Swimming and persons with mild persistant asthma. TheScientificWorldJournal, 2007, Aug-17, Volume: 7 Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Beclomethasone; Bronchial Hyperreactivity; Femal	2007
Salmeterol plus fluticasone propionate versus fluticasone propionate plus montelukast: a randomised controlled trial investigating the effects on airway inflammation in asthma. Respiratory research, 2007, Sep-27, Volume: 8 Topics: Acetates; Adrenergic beta-Agonists; Adult; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma;	2007
[A clinical study on the significance of airway hyperresponsiveness monitoring in the adjustment of combined therapy for asthmatic patients]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2007, Volume: 30, Issue:7 Topics: Adolescent; Adult; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivi	2007
Does measuring BHR add to guideline derived clinical measures in determining treatment for patients with persistent asthma? Respiratory medicine, 2008, Volume: 102, Issue:5 Topics: Administration, Inhalation; Adolescent; Adult; Aged; Aged, 80 and over; Albuterol; Androstadienes; A	2008
Effect of zatebradine, a novel 'sinus node inhibitor', on pulmonary function compared to placebo. Pulmonary pharmacology, 1994, Volume: 7, Issue:6 Topics: Adolescent; Adult; Aged; Albuterol; Asthma; Benzazepines; Bronchial Hyperreactivity; Cardiovascular	1994
[Role of anticholinergic agents in the treatment of cystic fibrosis]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1995, Volume: 2 Suppl 2 Topics: Albuterol; Bronchial Hyperreactivity; Child; Cystic Fibrosis; Drug Combinations; Forced Expiratory V	1995
GR106642X: a new, non-ozone depleting propellant for inhalers. BMJ (Clinical research ed.), 1995, Jun-24, Volume: 310, Issue:6995 Topics: Aerosol Propellants; Albuterol; Asthma; Bronchial Hyperreactivity; Cross-Over Studies; Double-Blind	1995
Asthma symptoms and airway hyperresponsiveness are lower during treatment with nedocromil sodium than during treatment with regular inhaled albuterol. The Journal of allergy and clinical immunology, 1995, Volume: 95, Issue:2 Topics: Administration, Inhalation; Adolescent; Adult; Aged; Albuterol; Analysis of Variance; Asthma; Bronch	1995
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[Reference controlled, randomized double-blind study of the effectiveness of a salbutamol/DNCG DA combination in bronchial hyperreactivity in comparison with salbutamol DA alone (parallel group comparison)]. Pneumologie (Stuttgart, Germany), 1993, Volume: 47, Issue:7 Topics: Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cromolyn Sodium; D	1993
The effect of salbutamol controlled release on airways responsiveness to inhaled methacholine in mild asthmatic subjects. Respiratory medicine, 1993, Volume: 87, Issue:1 Topics: Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Delayed-Action Pre	1993
Duration of preventive effect of inhaled salbutamol on early airway response to allergen in asthmatic subjects. Respiratory medicine, 1993, Volume: 87, Issue:2 Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Allergens; Asthma; Bronchial Hyperreactivi	1993
Short-term and long-term effects of albuterol aerosol therapy in cystic fibrosis: a preliminary report. Pediatric pulmonology, 1995, Volume: 20, Issue:4 Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchi;	1995
Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:5 Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Anti-Asthm	1996
Diurnal change of bronchial caliber and airway responsiveness in asthmatics during long-term treatment with long-acting beta 2-agonist salmeterol. International journal of clinical pharmacology and therapeutics, 1996, Volume: 34, Issue:10 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Analysis of Variance; Asthma	1996
Effect of regular nedocromil sodium or albuterol on bronchial inflammation in chronic asthma. The Journal of allergy and clinical immunology, 1996, Volume: 98, Issue:5 Pt 2 Topics: Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchitis; Chronic Disease; Double-Blind Metho	1996
[Long-term effects of inhaled beta 2-agonists on bronchial hyperresponsiveness in asthmatics]. Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:11 Topics: Administration, Oral; Adrenergic beta-Agonists; Albuterol; Asthma; Bronchial Hyperreactivity; Fenote	1996
Effect of regular inhaled salbutamol on airway responsiveness and airway inflammation in rhinitic non-asthmatic subjects. Thorax, 1997, Volume: 52, Issue:2 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Bronchial Hyperreactivity; B	1997
Fluticasone propionate, salmeterol xinafoate, and their combination in the treatment of nocturnal asthma. American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:4 Topics: Adenosine Monophosphate; Administration, Inhalation; Administration, Topical; Adrenergic beta-Agonis	1997
The effect of regular salbutamol on lung function and bronchial hyperresponsiveness in normal subjects and nonasthmatic atopic subjects with allergic rhinitis. Chest, 1997, Volume: 112, Issue:1 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Bronchial Hyperreactivity; Bronchia	1997
Effect of regular salmeterol treatment on albuterol-induced bronchoprotection in mild asthma. American journal of respiratory and critical care medicine, 1997, Volume: 156, Issue:3 Pt 1 Topics: Adenosine Monophosphate; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Hyperreactivi	1997
A comparison of beclomethasone, salmeterol, and placebo in children with asthma. Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group. The New England journal of medicine, 1997, Dec-04, Volume: 337, Issue:23 Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Albuterol; Asthma; Beclomethasone;	1997
Long-term effects of formoterol and salbutamol on bronchial hyperreactivity and beta-adrenoceptor density on lymphocytes in children with bronchial asthma. European journal of medical research, 1996, Jul-25, Volume: 1, Issue:10 Topics: Adrenergic beta-Agonists; Airway Resistance; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchodi	1996
Possible interaction between exposure to environmental tobacco smoke and therapy in children with asthma. Clinical science (London, England : 1979), 1998, Volume: 95, Issue:2 Topics: Adolescent; Albuterol; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; B	1998
The bronchoprotective efficacy of salbutamol inhaled from a new metered-dose powder inhaler compared with a conventional pressurized metered-dose inhaler connected to a spacer. Respiratory medicine, 1998, Volume: 92, Issue:3 Topics: Adult; Albuterol; Bronchial Hyperreactivity; Bronchodilator Agents; Cross-Over Studies; Double-Blind	1998
A randomised, placebo controlled trial of inhaled salbutamol and beclomethasone for recurrent cough. Archives of disease in childhood, 1998, Volume: 79, Issue:1 Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Albuterol; Beclomethasone; Bronchi	1998
Combined intravenous lidocaine and inhaled salbutamol protect against bronchial hyperreactivity more effectively than lidocaine or salbutamol alone. Anesthesiology, 1998, Volume: 89, Issue:4 Topics: Administration, Inhalation; Adult; Albuterol; Anesthetics, Local; Blood Pressure; Bronchial Hyperrea	1998
Relationships between duration of asthma and asthma severity among children in the Childhood Asthma Management Program (CAMP) The Journal of allergy and clinical immunology, 1999, Volume: 103, Issue:3 Pt 1 Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Albuterol; Allergens; Anti-Asthmatic	1999
Relationships between duration of asthma and asthma severity among children in the Childhood Asthma Management Program (CAMP) The Journal of allergy and clinical immunology, 1999, Volume: 103, Issue:3 Pt 1 Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Albuterol; Allergens; Anti-Asthmatic	1999
Relationships between duration of asthma and asthma severity among children in the Childhood Asthma Management Program (CAMP) The Journal of allergy and clinical immunology, 1999, Volume: 103, Issue:3 Pt 1 Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Albuterol; Allergens; Anti-Asthmatic	1999
Relationships between duration of asthma and asthma severity among children in the Childhood Asthma Management Program (CAMP) The Journal of allergy and clinical immunology, 1999, Volume: 103, Issue:3 Pt 1 Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Albuterol; Allergens; Anti-Asthmatic	1999
Effect of single doses of inhaled lignocaine on FEV1 and bronchial reactivity in asthma. Respiratory medicine, 1998, Volume: 92, Issue:12 Topics: Administration, Inhalation; Adult; Albuterol; Anesthetics, Local; Asthma; Bronchial Hyperreactivity;	1998
Peak flow variation in childhood asthma: correlation with symptoms, airways obstruction, and hyperresponsiveness during long-term treatment with inhaled corticosteroids. Dutch CNSLD Study Group. Thorax, 1999, Volume: 54, Issue:2 Topics: Administration, Inhalation; Administration, Topical; Adolescent; Airway Obstruction; Albuterol; Anti	1999
Effect of long-term salmeterol therapy compared with as-needed albuterol use on airway hyperresponsiveness. Chest, 1999, Volume: 116, Issue:3 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Aerosols; Albuterol; Asthma; Bronchial	1999
The effect of regular salbutamol on lung function and bronchial responsiveness in patients with primary ciliary dyskinesia. Chest, 2000, Volume: 117, Issue:2 Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Airway Resistance; Albuterol; Bron	2000
Additive bronchoprotective and bronchodilator effects with single doses of salmeterol and montelukast in asthmatic patients receiving inhaled corticosteroids. Chest, 2000, Volume: 117, Issue:4 Topics: Acetates; Adenosine Monophosphate; Administration, Inhalation; Administration, Oral; Adrenergic beta	2000
The protective effect of salbutamol inhaled using different devices on methacholine bronchoconstriction. Chest, 2000, Volume: 117, Issue:5 Topics: Adolescent; Adult; Aged; Airway Resistance; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial	2000
Combined lidocaine and salbutamol inhalation for airway anesthesia markedly protects against reflex bronchoconstriction. Chest, 2000, Volume: 118, Issue:2 Topics: Administration, Inhalation; Adult; Aerosols; Albuterol; Anesthesia, Inhalation; Anesthetics, Local;	2000
Salbutamol via Easyhaler is at least as effective as salbutamol via Turbuhaler in the treatment of histamine-induced bronchoconstriction. Respiratory medicine, 2000, Volume: 94, Issue:11 Topics: Administration, Inhalation; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocati	2000
Regular inhaled salbutamol : effect on airway responsiveness to methacholine and adenosine 5'-monophosphate and tolerance to bronchoprotection. Chest, 2001, Volume: 119, Issue:2 Topics: Adenosine Monophosphate; Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Ast	2001
The effect of salmeterol on markers of airway inflammation following segmental allergen challenge. American journal of respiratory and critical care medicine, 2001, Volume: 163, Issue:4 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Allergens; Analysis of Varia	2001
A placebo-controlled clinical trial of regular monotherapy with short-acting and long-acting beta(2)-agonists in allergic asthmatic patients. Chest, 2001, Volume: 119, Issue:5 Topics: Adrenergic beta-Agonists; Adult; Albuterol; Allergens; Animals; Asthma; Bronchial Hyperreactivity; D	2001
Potential masking effect on dyspnoea perception by short- and long-acting beta2-agonists in asthma. The European respiratory journal, 2002, Volume: 19, Issue:2 Topics: Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial	2002
Is the increase in bronchial responsiveness or FEV1 shortly after cessation of beta2-agonists reflecting a real deterioration of the disease in allergic asthmatic patients? A comparison between short-acting and long-acting beta2-agonists. Respiratory medicine, 2002, Volume: 96, Issue:3 Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Double-Blind Method;	2002
A comparative study in atopic subjects with asthma of the effects of salmeterol and salbutamol on allergen-induced bronchoconstriction, increase in airway reactivity, and increase in urinary leukotriene E4 excretion. The Journal of allergy and clinical immunology, 1992, Volume: 89, Issue:2 Topics: Adrenergic beta-Agonists; Albuterol; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provoca	1992
Separate and combined effects of corticosteroids and bronchodilators on airflow obstruction and airway hyperresponsiveness in asthma. The Journal of allergy and clinical immunology, 1992, Volume: 89, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Airway Obstruction; Airway Resistance; Albuterol; Asthma; Bronchial	1992
Efficacy of salbutamol and ipratropium bromide in decreasing bronchial hyperreactivity in children with cystic fibrosis. Pediatric pulmonology, 1992, Volume: 13, Issue:1 Topics: Adolescent; Albuterol; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cystic Fibrosi	1992
The inhibitory effect of nebulized albuterol on the early and late asthmatic reactions and increase in airway responsiveness provoked by inhaled allergen in asthma. The American review of respiratory disease, 1991, Volume: 144, Issue:4 Topics: Administration, Inhalation; Adult; Albuterol; Allergens; Asthma; Bronchial Hyperreactivity; Bronchia	1991

Article	Year
Neutrophilic inflammation in asthma and defective epithelial translational control. The European respiratory journal, 2019, Volume: 54, Issue:2 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Albuterol; Asthma; Bronchi; Bronchial Hyperreactiv	2019
Effects of chronic administration of β-blockers on airway responsiveness in a murine model of heart failure. Pulmonary pharmacology & therapeutics, 2014, Volume: 28, Issue:2 Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Agonists; Albuterol; Animals; Bro	2014
Acute effect of insulin on guinea pig airways and its amelioration by pre-treatment with salbutamol. JPMA. The Journal of the Pakistan Medical Association, 2014, Volume: 64, Issue:8 Topics: Albuterol; Animals; Bronchial Hyperreactivity; Bronchodilator Agents; Female; Guinea Pigs; Insulin;	2014
Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma. Journal of aerosol medicine and pulmonary drug delivery, 2016, Volume: 29, Issue:3 Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Agammaglobulinaemia Tyrosine Kinase	2016
Airway Remodeling and Hyperreactivity in a Model of Bronchopulmonary Dysplasia and Their Modulation by IL-1 Receptor Antagonist. American journal of respiratory cell and molecular biology, 2016, Volume: 55, Issue:6 Topics: Airway Remodeling; Albuterol; Animals; Bronchial Hyperreactivity; Bronchopulmonary Dysplasia; Diseas	2016
Response to bronchodilators after exercise challenge predicts bronchial hyperreactivity. The Journal of asthma : official journal of the Association for the Care of Asthma, 2008, Volume: 45, Issue:5 Topics: Adolescent; Adult; Albuterol; Bayes Theorem; Bronchial Hyperreactivity; Bronchial Provocation Tests;	2008
Assessing mortality risk in COPD. Journal of insurance medicine (New York, N.Y.), 2008, Volume: 40, Issue:1 Topics: Actuarial Analysis; Albuterol; Androstadienes; Body Mass Index; Bronchial Hyperreactivity; Bronchodi	2008
Two pharmacological phases in antigen-induced immediate airway response in rats. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:12 Topics: Administration, Inhalation; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Agonists; Albutero	2008
Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. American journal of respiratory cell and molecular biology, 2009, Volume: 41, Issue:4 Topics: Airway Resistance; Albuterol; Animals; Bronchial Hyperreactivity; Cells, Cultured; Disease Models, A	2009
Effect of interleukin 13 on bronchial hyperresponsiveness and the bronchoprotective effect of beta-adrenergic bronchodilators and corticosteroids. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2009, Volume: 102, Issue:3 Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Albuterol; Androstadienes; Animals; Bronchial Hyp	2009
The beta2 receptor and airway hyper-responsiveness: are sensory nerves involved? Thorax, 2009, Volume: 64, Issue:9 Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Bronchial Hyperreactivity; Humans; Neurons, Afferent; R	2009
Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of β-receptor affinity in murine models of asthma. Respiratory research, 2011, Mar-07, Volume: 12 Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Albuterol; Analysis of Variance; An	2011
Induced sputum in children: success determinants, safety, and cell profiles. Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:3 Topics: Administration, Inhalation; Adolescent; Albuterol; Asthma; Bronchial Hyperreactivity; Cell Count; Ch	2011
Relationship between bronchial hyperreactivity and bronchodilation in patients with allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2011, Volume: 106, Issue:6 Topics: Adult; Albuterol; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodi	2011
Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsiveness. Respiratory research, 2011, Jul-15, Volume: 12 Topics: Adolescent; Airway Resistance; Albuterol; Asthma; Boston; Bronchial Hyperreactivity; Bronchial Provo	2011
Inhibition of airway hyper-responsiveness by TRPV1 antagonists (SB-705498 and PF-04065463) in the unanaesthetized, ovalbumin-sensitized guinea pig. British journal of pharmacology, 2012, Volume: 166, Issue:6 Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Allergens; Animals; Atropine; Bronchial Hyperreactiv	2012
Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:2 Topics: Albuterol; Animals; Asthma; beta-Alanine; Bronchial Hyperreactivity; Bronchoconstriction; Fingolimod	2012
The current landscape of asthma: a new geometry. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:4 Topics: Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Drug Combinatio	2002
Impulse oscillometry provides an effective measure of lung dysfunction in 4-year-old children at risk for persistent asthma. The Journal of allergy and clinical immunology, 2003, Volume: 112, Issue:2 Topics: Airway Resistance; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents; Child, Presc	2003
Airway responsiveness to beta-adrenergic agonist (salbutamol) in asthma. The Journal of asthma : official journal of the Association for the Care of Asthma, 2003, Volume: 40, Issue:8 Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Bronchi; Bronchial Hyperreactivity; Bronch	2003
Prevention of bronchoconstriction in sensitized guinea pigs: efficacy of common prophylactic drugs. Respiratory physiology & neurobiology, 2004, Jul-20, Volume: 141, Issue:2 Topics: Adrenergic Agonists; Adrenergic beta-2 Receptor Agonists; Albuterol; Allergens; Analysis of Variance	2004
Pulmonary outcome in adolescents of extreme preterm birth: a regional cohort study. Acta paediatrica (Oslo, Norway : 1992), 2004, Volume: 93, Issue:10 Topics: Adolescent; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchopulmon	2004
Airway reactivity is a determinant of bronchodilator responsiveness after methacholine-induced bronchoconstriction. The Journal of asthma : official journal of the Association for the Care of Asthma, 2004, Volume: 41, Issue:6 Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchi	2004
The GOAL study: designed to favor a long-acting beta2-agonist? American journal of respiratory and critical care medicine, 2005, May-01, Volume: 171, Issue:9 Topics: Adrenergic beta-Agonists; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Bronchial Hyperr	2005
Effects of salbutamol and enantiomers on allergen-induced asthmatic reactions and airway hyperreactivity. The European respiratory journal, 2005, Volume: 25, Issue:5 Topics: Albuterol; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Guinea Pig	2005
Risk factors of bronchial hyperresponsiveness in children with wheezing-associated respiratory infection. Pediatric pulmonology, 2005, Volume: 40, Issue:1 Topics: Administration, Inhalation; Age Distribution; Albuterol; Bronchial Hyperreactivity; Bronchodilator A	2005
Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model. The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:2 Topics: Adrenergic beta-Agonists; Albuterol; Animals; Apoptosis; Asthma; Bronchial Hyperreactivity; Disease	2005
Inhaled lysophosphatidylcholine provokes bronchoconstriction in guinea pigs in vivo. European journal of pharmacology, 2005, Sep-27, Volume: 520, Issue:1-3 Topics: 1,2-Dipalmitoylphosphatidylcholine; Administration, Inhalation; Albuterol; Animals; Bronchial Hyperr	2005
Recognition of asthma in adolescents and young adults: which objective measure is best? The Journal of asthma : official journal of the Association for the Care of Asthma, 2005, Volume: 42, Issue:7 Topics: Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Anti-Asthmatic Agents; Antigens; Asthma; Bro	2005
The structural basis of airways hyperresponsiveness in asthma. Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 101, Issue:6 Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchoconstriction;	2006
Formoterol and beclomethasone dipropionate interact positively in antagonising bronchoconstriction and inflammation in the lung. Pharmacological research, 2007, Volume: 55, Issue:5 Topics: Acetylcholine; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Albuterol; Animals; An	2007
Prevention of changes in airway function facilitates Strongyloides venezuelensis infection in rats. Microbes and infection, 2007, Volume: 9, Issue:7 Topics: Acetylcholine; Albuterol; Animals; Bronchial Hyperreactivity; Bronchodilator Agents; Eosinophilia; G	2007
Heterogeneity of bronchoconstriction does not distinguish mild asthmatic subjects from healthy controls when supine. Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:1 Topics: Adolescent; Adult; Airway Resistance; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provoc	2008
Isbufylline, a new xanthine derivative, inhibits airway hyperresponsiveness and airway inflammation in guinea pigs. European journal of pharmacology, 1993, Nov-16, Volume: 249, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Albuterol; Animals; Bronchial Hyperreactivity; Bronchoal	1993
Hyperresponsiveness of the airways following exposure of guinea-pigs to racemic mixtures and distomers of beta 2-selective sympathomimetics. Pulmonary pharmacology, 1994, Volume: 7, Issue:6 Topics: Administration, Topical; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Airway Resis	1994
Synergistic protective effects with azelastine and salbutamol in a guinea pig asthma model. Research communications in molecular pathology and pharmacology, 1995, Volume: 87, Issue:2 Topics: Administration, Oral; Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents;	1995
[The therapeutic potentials of Ditec in bronchial asthma patients]. Terapevticheskii arkhiv, 1995, Volume: 67, Issue:3 Topics: Adult; Aerosols; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cromolyn	1995
[Bronchial hyperresponsiveness and relaxability in patients with mitral stenosis]. Nihon Kyobu Shikkan Gakkai zasshi, 1994, Volume: 32, Issue:11 Topics: Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Humans; Male; Met	1994
Methoctramine induces nonspecific airway hyperresponsiveness in vivo. European journal of pharmacology, 1994, Nov-14, Volume: 265, Issue:1-2 Topics: Aerosols; Albuterol; Animals; Arachidonic Acid; Atropine; Bronchial Hyperreactivity; Bronchoconstric	1994
Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor. British journal of pharmacology, 1994, Volume: 113, Issue:4 Topics: Albuterol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Bronchial Hyperreactivity;	1994
Asthma control. Lancet (London, England), 1994, Jul-16, Volume: 344, Issue:8916 Topics: Albuterol; Asthma; Bronchial Hyperreactivity; Humans; Sympathomimetics	1994
[Relations between nonspecific bronchial hyperreactivity, diurnal variation of peak expiratory flow and medication requirements in patients with mild asthma]. Archivos de bronconeumologia, 1994, Volume: 30, Issue:9 Topics: Adolescent; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents; Circadian Rh	1994
Enhancement of airway reactivity to histamine by isoprenaline and related beta-adrenoceptor agonists in the guinea-pig. British journal of pharmacology, 1993, Volume: 108, Issue:4 Topics: Adrenergic beta-Agonists; Albuterol; Animals; Bronchi; Bronchial Hyperreactivity; Epinephrine; Guine	1993
Allergic bronchial eosinophilia: a therapeutic approach for the selection of potential bronchial anti-inflammatory drugs. Allergy, 1993, Volume: 48, Issue:8 Topics: Albuterol; Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoa	1993
Exacerbation of airway hyperreactivity by (+/-)salbutamol in sensitized guinea pig. Japanese journal of pharmacology, 1993, Volume: 63, Issue:2 Topics: Airway Obstruction; Albuterol; Animals; Bronchial Hyperreactivity; Guinea Pigs; Male; Ovalbumin; Res	1993
Oxidative epithelial damage produces hyperresponsiveness of human peripheral airways. American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:2 Pt 1 Topics: Albuterol; Bronchi; Bronchial Hyperreactivity; Epithelium; Female; Histamine; Humans; Hydrogen Perox	1994
Influence of airway inflammatory changes on airway hyperresponsiveness in asthmatics. Chinese medical journal, 1993, Volume: 106, Issue:4 Topics: Adult; Albuterol; Asthma; Beclomethasone; Bronchial Hyperreactivity; Bronchial Provocation Tests; Br	1993
Paradoxical bronchoconstriction with nebulized albuterol but not with terbutaline. The American review of respiratory disease, 1993, Volume: 148, Issue:2 Topics: Adult; Aerosols; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoc	1993
[Bronchial hyperreactivity after chronic use of salbutamol]. Pneumonologia i alergologia polska, 1993, Volume: 61, Issue:3-4 Topics: Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Female; Humans; Male; Spirometry	1993
Ketotifen inhibits exacerbation of allergic airway hyperreactivity by racemic salbutamol in the guinea pig. The Journal of allergy and clinical immunology, 1993, Volume: 91, Issue:4 Topics: Albuterol; Animals; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Guinea Pigs; Hydroc	1993
Assessment of bronchodilator response in children with asthma. Dutch CNSLD Study Group. The European respiratory journal, 1993, Volume: 6, Issue:5 Topics: Adolescent; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Forced	1993
[Effect of 16-week use of salmeterol on ECP levels, pulmonary function tests and bronchial hyperreactivity in patients with chronic obstructive lung disease]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1995, Volume: 50, Issue:40-44 Topics: Albuterol; Blood Proteins; Bronchial Hyperreactivity; Bronchodilator Agents; Eosinophil Granule Prot	1995
Salbutamol-induced airway hyperreactivity in guinea pigs is not due to a loss of its bronchodilator effect. European journal of pharmacology, 1995, Dec-04, Volume: 287, Issue:1 Topics: Adrenergic beta-Agonists; Albuterol; Animals; Bombesin; Bronchial Hyperreactivity; Bronchoconstricti	1995
Relationship between the acid-induced cough response and airway responsiveness and obstruction in children with asthma. Thorax, 1996, Volume: 51, Issue:3 Topics: Acetates; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator	1996
Effects of immunotherapy on symptoms, PEFR, spirometry, and airway responsiveness in patients with allergic asthma to house-dust mites (D. pteronyssinus) on inhaled steroid therapy. Allergy, 1996, Volume: 51, Issue:4 Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Allergens; Animals; Antigens, Dermatophago	1996
S-albuterol exacerbates calcium responses to carbachol in airway smooth muscle cells. Clinical reviews in allergy & immunology, 1996,Spring, Volume: 14, Issue:1 Topics: Albuterol; Animals; Bronchial Hyperreactivity; Calcium; Carbachol; Cattle; Cells, Cultured; Muscle,	1996
Effects of albuterol enantiomers on in vitro bronchial reactivity. Clinical reviews in allergy & immunology, 1996,Spring, Volume: 14, Issue:1 Topics: Albuterol; Animals; Bronchi; Bronchial Hyperreactivity; Guinea Pigs; In Vitro Techniques; Male; Musc	1996
Effects of RS-albuterol on the development of antigen-mediated airway hyperreactivity in guinea pigs. Clinical reviews in allergy & immunology, 1996,Spring, Volume: 14, Issue:1 Topics: Aerosols; Albuterol; Animals; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Female; G	1996
Differential responses of asthmatic airways to enantiomers of albuterol. Implications for clinical treatment of asthma. Clinical reviews in allergy & immunology, 1996,Spring, Volume: 14, Issue:1 Topics: Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Guinea Pigs; Humans	1996
Allergen challenge of passively sensitized human bronchi alters M2 and beta2 receptor function. American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:4 Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Allergens; Animals; Asthma; Bronchi; Bronchial Hyp	1997
Effect of beta 2-agonists on histamine-induced airway microvascular leakage in ozone-exposed guinea pigs. American journal of respiratory and critical care medicine, 1997, Volume: 156, Issue:3 Pt 1 Topics: Adrenergic beta-Agonists; Airway Resistance; Albuterol; Animals; Blood-Air Barrier; Bronchial Hyperr	1997
A guinea-pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. The European respiratory journal, 1997, Volume: 10, Issue:10 Topics: Administration, Inhalation; Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provoca	1997
The utility of methacholine airway responsiveness measurements in evaluating anti-asthma drugs. The Journal of allergy and clinical immunology, 1998, Volume: 101, Issue:3 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Allergens; Anti-Asthmatic Agents; A	1998
Reduced long-term respiratory morbidity after treatment of respiratory syncytial virus bronchiolitis with ribavirin in previously healthy infants: a preliminary report. Pediatric pulmonology, 1998, Volume: 25, Issue:3 Topics: Albuterol; Antiviral Agents; Asthma; Bronchial Hyperreactivity; Bronchiolitis; Bronchodilator Agents	1998
[Osmolarity of solutions used in nebulization]. Revue des maladies respiratoires, 1998, Volume: 15, Issue:2 Topics: Acetylcysteine; Administration, Inhalation; Aerosols; Albuterol; Anti-Asthmatic Agents; Bicarbonates	1998
Selective airway responsiveness in asthma. Trends in pharmacological sciences, 1999, Volume: 20, Issue:1 Topics: Albuterol; Animals; Asthma; Bradykinin; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronch	1999
Difference in bronchoprotective effects of bronchodilators on postallergic propranolol-induced bronchoconstriction. Experimental lung research, 1999, Volume: 25, Issue:6 Topics: Airway Resistance; Albuterol; Aminophylline; Animals; Atropine; Bronchi; Bronchial Hyperreactivity;	1999
Identification of mechanisms involved in the acute airway toxicity induced by parathion. Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:6 Topics: Acetylcholinesterase; Airway Resistance; Albuterol; Animals; Body Water; Bronchial Hyperreactivity;	1999
Use of pocket-sized turbine spirometer in monitoring exercise-induced bronchospasm and bronchodilator responses in children. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 1999, Volume: 10, Issue:4 Topics: Adolescent; Albuterol; Bronchial Hyperreactivity; Bronchial Spasm; Bronchodilator Agents; Bronchospi	1999
Long-acting beta(2)-agonists in childhood asthma: Don't change a winning team (yet) Pediatric pulmonology, 2000, Volume: 29, Issue:3 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Asthma; Bronchial Hyperreactivity;	2000
Familial aggregation of bronchodilator response: a community-based study. American journal of respiratory and critical care medicine, 2000, Volume: 162, Issue:5 Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchi;	2000
Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice. American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 280, Issue:3 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Allergens; Animals; Bronchial Hyper	2001
Levalbuterol and racemic albuterol: are there therapeutic differences? The Journal of allergy and clinical immunology, 2001, Volume: 108, Issue:5 Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Spasm; Bronchodila	2001
Racemic salbutamol administration to guinea-pigs selectively augments airway smooth muscle responsiveness to cholinoceptor agonists. Journal of autonomic pharmacology, 2001, Volume: 21, Issue:4 Topics: Adrenergic beta-Agonists; Albuterol; Animals; Bronchial Hyperreactivity; Cholinergic Agonists; Drug	2001
RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo. Pulmonary pharmacology, 1992, Volume: 5, Issue:3 Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Albuterol; Anesthesia; A	1992
Asthma mortality and inhaled beta agonist therapy. Australian and New Zealand journal of medicine, 1992, Volume: 22, Issue:4 Topics: Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Guinea Pigs; Humans	1992
Effects of neuraminidase on airway reactivity in the guinea pig. The American review of respiratory disease, 1992, Volume: 145, Issue:4 Pt 1 Topics: Albuterol; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Guinea Pigs; Male; Nepri	1992
[The role of pharmacological tests in detecting disorders in the bronchial patency and bronchial reactivity of patients with chronic glomerulonephritis]. Likars'ka sprava, 1992, Issue:6 Topics: Acetylcholine; Adolescent; Adult; Albuterol; Bronchi; Bronchial Hyperreactivity; Bronchial Provocati	1992
Perception of bronchoconstriction in chronic asthma. The Journal of asthma : official journal of the Association for the Care of Asthma, 1992, Volume: 29, Issue:5 Topics: Aerosols; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female;	1992
Reversible volume changes of trapped gas in nonspecific bronchoprovocation tests. Chest, 1992, Volume: 101, Issue:4 Topics: Acetylcholine; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Forced Exp	1992
Respiratory symptoms as predictors of airways lability in an elderly population. Respiratory medicine, 1992, Volume: 86, Issue:1 Topics: Aged; Aged, 80 and over; Albuterol; Bronchial Hyperreactivity; Female; Humans; Lung; Lung Diseases,	1992
Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs. Drugs under experimental and clinical research, 1991, Volume: 17, Issue:8 Topics: Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Chemotaxis, Leukocyte; Guinea Pigs; Male; Pla	1991
Bronchial hyperreactivity in children with Marfan syndrome. Pediatric pulmonology, 1991, Volume: 11, Issue:1 Topics: Adolescent; Albuterol; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Forced	1991

albuterol and Bronchial Hyperreactivity