Page last updated: 2024-10-22

albuterol and Acidosis, Respiratory

albuterol has been researched along with Acidosis, Respiratory in 6 studies

Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Acidosis, Respiratory: Respiratory retention of carbon dioxide. It may be chronic or acute.

Research Excerpts

ExcerptRelevanceReference
" Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively."8.02Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021)
" Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively."4.02Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021)
"Acute exacerbations of chronic obstructive pulmonary disease (COPD)--characterized by shortness of breath, increased sputum production, increased purulence, or a combination of these signs--are costly and can have major impacts on the patient's health."2.53Treating and preventing acute exacerbations of COPD. ( Aboussouan, LS; Hatipoglu, US, 2016)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Phoophiboon, V1
Singhagowinta, P1
Boonkaya, S1
Sriprasart, T1
Cancado, JE1
Mendes, ES1
Arana, J1
Horvath, G1
Monzon, ME1
Salathe, M1
Wanner, A1
Hatipoglu, US1
Aboussouan, LS1
Mazzeo, AT1
Spada, A1
Praticò, C1
Lucanto, T1
Santamaria, LB1
Haddad, S1
Arabi, Y1
Shimemeri, AA1
Anderson, SD1
Silverman, M1
König, P1
Godfrey, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Evidence of pH Dependent ß2 Adrenergic Transport Mechanisms in the Airway[NCT01216748]10 participants (Actual)Interventional2010-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Changes in Airway Blood Flow After 180μg Albuterol by Inhalation (ΔQaw) vs Baseline

Effect of airway pH on albuterol responsiveness as reflected by the change in airway blood flow after 180μg albuterol by inhalation (ΔQaw) vs baseline. (NCT01216748)
Timeframe: 15 minutes after albuterol inhalation

Interventionchanges from baseline in μl.min-1.ml-1 (Mean)
quiet breathingeucapnic hyperventilationhypocapnic hyperventilationhypercapnic hyperventilation
Health Controls16.814.5-0.22.0

Exhaled Breath Condensate (EBC) pH Variation

"EBC samples were collected at each respiratory maneuver by directing the subject's exhaled breath into a pre-cooled (-10C) tube for 10 min.~pH was measured immediately after collection." (NCT01216748)
Timeframe: 10 minutes after each respiratory manouver.

InterventionpH (Mean)
quiet breathinghypocapnic hyperventilationhypercapnic hyperventilationeucapnic hyperventilation
Health Controls6.396.316.595.88

Reviews

1 review available for albuterol and Acidosis, Respiratory

ArticleYear
Treating and preventing acute exacerbations of COPD.
    Cleveland Clinic journal of medicine, 2016, Volume: 83, Issue:4

    Topics: Acidosis, Respiratory; Acute Disease; Administration, Inhalation; Albuterol; Anti-Bacterial Agents;

2016

Trials

1 trial available for albuterol and Acidosis, Respiratory

ArticleYear
Effect of airway acidosis and alkalosis on airway vascular smooth muscle responsiveness to albuterol.
    BMC pharmacology & toxicology, 2015, Apr-02, Volume: 16

    Topics: Acidosis, Respiratory; Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Adult; Albut

2015

Other Studies

4 other studies available for albuterol and Acidosis, Respiratory

ArticleYear
Salbutamol-induced lactic acidosis in status asthmaticus survivor.
    BMC pulmonary medicine, 2021, Jan-12, Volume: 21, Issue:1

    Topics: Acidosis; Acidosis, Lactic; Acidosis, Respiratory; Adrenergic beta-2 Receptor Agonists; Adult; Albut

2021
Hypercapnia: what is the limit in paediatric patients? A case of near-fatal asthma successfully treated by multipharmacological approach.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:7

    Topics: Acidosis, Respiratory; Albuterol; Asthma; Bronchodilator Agents; Child; Drug Therapy, Combination; G

2004
Hypokalemic paralysis mimicking Guillain-Barré syndrome and causing acute respiratory failure.
    Middle East journal of anaesthesiology, 2004, Volume: 17, Issue:5

    Topics: Acidosis, Respiratory; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Blood Gas Analysis; Diagn

2004
Exercise-induced asthma.
    British journal of diseases of the chest, 1975, Volume: 69, Issue:1

    Topics: Acidosis, Respiratory; Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Airway Obstruction; Air

1975