albendazole has been researched along with Pregnancy in 88 studies
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Excerpt | Relevance | Reference |
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"A randomized open-label trial, including 834 pregnant women, examined efficacy and recorded adverse events of ivermectin (ivc) and albendazole (alb) alone and combined (comb) on soil-transmitted helminth infections (STHs) in the second trimester of pregnancy." | 9.13 | Efficacy of ivermectin and albendazole alone and in combination for treatment of soil-transmitted helminths in pregnancy and adverse events: a randomized open label controlled intervention trial in Masindi district, western Uganda. ( Kabatereine, N; Magnussen, P; Ndyomugyenyi, R; Olsen, A, 2008) |
"In Entebbe, Uganda, we conducted a randomised, double-blind, placebo-controlled trial of a single dose of 400 mg of albendazole in the second trimester of pregnancy." | 9.11 | A randomised controlled trial of the effects of albendazole in pregnancy on maternal responses to mycobacterial antigens and infant responses to Bacille Calmette-Guérin (BCG) immunisation [ISRCTN32849447]. ( Belisle, JT; Elliott, AM; Mawa, PA; Muwanga, M; Nampijja, M; Namujju, PB; Nkurunziza, PM; Quigley, MA; Whitworth, JA, 2005) |
" Due to heterogeneity in terms of study design, sample size, deworming drug, dosage and outcomes measured, data from these studies could not be pooled." | 6.61 | Systematic review of exposure to albendazole or mebendazole during pregnancy and effects on maternal and child outcomes, with particular reference to exposure in the first trimester. ( Gyorkos, TW; St-Denis, K, 2019) |
" During pregnancy, women were randomized, simultaneously, to albendazole vs placebo and to praziquantel vs placebo." | 5.24 | Effects of treating helminths during pregnancy and early childhood on risk of allergy-related outcomes: Follow-up of a randomized controlled trial. ( Akello, F; Akurut, H; Elliott, AM; Kabagenyi, J; Kizza, M; Lule, SA; Mpairwe, H; Muhangi, L; Muwanga, M; Namara, B; Nash, S; Nkurunungi, G; Tumusiime, J; Webb, EL, 2017) |
"Routine use of albendazole in pregnancy may not always be beneficial, even in tropical developing countries." | 5.16 | Impact of anthelminthic treatment in pregnancy and childhood on immunisations, infections and eczema in childhood: a randomised controlled trial. ( Akello, F; Akurut, H; Alcock, KJ; Apule, B; Elliott, AM; Kihembo, M; Kizindo, R; Kizito, D; Kizza, M; Lule, SA; Mawa, PA; Mpairwe, H; Muhangi, L; Muwanga, M; Nampijja, M; Naniima, P; Ndibazza, J; Oduru, G; Rutebarika, D; Tweyongere, R; Webb, EL, 2012) |
"To investigate the effect of helminth infections and their treatment during pregnancy on HIV load, we conducted a 2 × 2 factorial randomized controlled trial of albendazole versus placebo and praziquantel versus placebo in pregnant women in Entebbe, Uganda." | 5.16 | The effect of anthelmintic treatment during pregnancy on HIV plasma viral load: results from a randomized, double-blind, placebo-controlled trial in Uganda. ( Elliott, AM; Kaleebu, P; Kizito, D; Kyosiimire-Lugemwa, J; Lule, S; Muhangi, L; Muwanga, M; Nkurunziza, P; Webb, EL, 2012) |
"A randomised, double-blind, placebo-controlled trial on treatment in pregnancy with albendazole versus placebo and praziquantel versus placebo was conducted in Uganda, with a 2 × 2 factorial design; 2507 women were enrolled; infants' allergy events were recorded prospectively." | 5.15 | Anthelminthic treatment during pregnancy is associated with increased risk of infantile eczema: randomised-controlled trial results. ( Akishule, D; Dunne, DW; Elliott, AM; Fitzsimmons, C; Jones, FM; Mpairwe, H; Muhangi, L; Muwanga, M; Nampijja, M; Ndibazza, J; Ngom-wegi, S; Rodrigues, LC; Tumusime, J; Webb, EL, 2011) |
"A randomized open-label trial, including 834 pregnant women, examined efficacy and recorded adverse events of ivermectin (ivc) and albendazole (alb) alone and combined (comb) on soil-transmitted helminth infections (STHs) in the second trimester of pregnancy." | 5.13 | Efficacy of ivermectin and albendazole alone and in combination for treatment of soil-transmitted helminths in pregnancy and adverse events: a randomized open label controlled intervention trial in Masindi district, western Uganda. ( Kabatereine, N; Magnussen, P; Ndyomugyenyi, R; Olsen, A, 2008) |
"In Entebbe, Uganda, we conducted a randomised, double-blind, placebo-controlled trial of a single dose of 400 mg of albendazole in the second trimester of pregnancy." | 5.11 | A randomised controlled trial of the effects of albendazole in pregnancy on maternal responses to mycobacterial antigens and infant responses to Bacille Calmette-Guérin (BCG) immunisation [ISRCTN32849447]. ( Belisle, JT; Elliott, AM; Mawa, PA; Muwanga, M; Nampijja, M; Namujju, PB; Nkurunziza, PM; Quigley, MA; Whitworth, JA, 2005) |
"A longitudinal study was conducted in Sierra Leone to measure the impact of a single dose anthelminthic (400 mg albendazole) and daily iron-folate supplements (36 g iron and 5 mg folate) on haemoglobin (HG) concentration during pregnancy." | 5.09 | Anthelminthic treatment and haemoglobin concentrations during pregnancy. ( Hodges, M; Torlesse, H, 2000) |
" Our analysis supports that albendazole in pregnancy has high cure rates for soil-transmitted helminths and is safe for the mother." | 5.05 | Treatment of soil-transmitted helminth infections in pregnancy: a systematic review and meta-analysis of maternal outcomes. ( Bhasker, S; Boggild, AK; Chris, RB; Khatib, A; Kopalakrishnan, S; Lau, R; Lecce, C; Mishra, S; Phuong, MS; Raheel, H; Yegorov, S, 2020) |
"The 'Informal Consultation on the Use of Praziquantel during Pregnancy/Lactation, and Albendazole/Mebendazole in Children under 24 Months' was held 8-9 April 2002, in Geneva, Switzerland." | 4.81 | New policies for using anthelmintics in high risk groups. ( Allen, HE; Crompton, DW; de Silva, N; LoVerde, PT; Olds, GR, 2002) |
" The lambs were treated with albendazole (SmithKline Beecham), fenbendazole (Hoechst Roussel) or a vitamin supplement and their weight gains were followed over the next 7 months." | 3.68 | Effects of an anthelmintic treatment programme on sheep productivity in the Middle Atlas, Morocco. ( Khallaayoune, K; Stromberg, BE, 1992) |
"Albendazole (400mg) was administered to assess efficacy and hookworm re-infection rate." | 3.11 | Hookworm re-infection rate and efficacy of single-dose albendazole among pregnant women in Debre Elias District, Northwest Ethiopia: A single-arm trial. ( Abebaw, A; Aschale, Y; Atnaf, A; Kassie, B; Mengist, A; Yihunie, W, 2022) |
"Eczema was doctor-diagnosed from birth to age five years." | 2.79 | Maternal hookworm modifies risk factors for childhood eczema: results from a birth cohort in Uganda. ( Akurut, H; Apule, B; Dunne, DW; Elliott, AM; Fitzsimmons, CM; Jones, FM; Kakande, M; Kizito, D; Lule, S; Mpairwe, H; Muhangi, L; Muwanga, M; Nampijja, M; Ndibazza, J; Rodrigues, LC; Webb, EL, 2014) |
"Albendazole (ABZ) has been used for control of ovine fasciolosis in Sweden for several decades." | 2.77 | The field evaluation of albendazole and triclabendazole efficacy against Fasciola hepatica by coproantigen ELISA in naturally infected sheep. ( Averpil, HB; Höglund, J; Novobilský, A, 2012) |
"Deworming during pregnancy has therefore been strongly advocated, but its benefits have not been rigorously evaluated." | 2.75 | Effects of deworming during pregnancy on maternal and perinatal outcomes in Entebbe, Uganda: a randomized controlled trial. ( Akishule, D; Ameke, C; Duong, T; Elliott, AM; Kiggundu, M; Kizindo, R; Kleinschmidt, I; Muhangi, L; Muwanga, M; Ndibazza, J; Oweka, J, 2010) |
"Helminthiasis is an infestation of the human body with parasitic worms." | 2.72 | Effect of mass deworming with antihelminthics for soil-transmitted helminths during pregnancy. ( Bhutta, ZA; Das, JK; Salam, RA, 2021) |
" Due to heterogeneity in terms of study design, sample size, deworming drug, dosage and outcomes measured, data from these studies could not be pooled." | 2.61 | Systematic review of exposure to albendazole or mebendazole during pregnancy and effects on maternal and child outcomes, with particular reference to exposure in the first trimester. ( Gyorkos, TW; St-Denis, K, 2019) |
"Helminthiasis is infestation of the human body with parasitic worms and it is estimated to affect 44 million pregnancies, globally, each year." | 2.52 | Effect of administration of antihelminthics for soil-transmitted helminths during pregnancy. ( Bhutta, ZA; Haider, BA; Humayun, Q; Salam, RA, 2015) |
"Helminthiasis is infestation of the human body with parasitic worms and it is estimated to affect 44 million pregnancies, globally, each year." | 2.45 | Effect of administration of antihelminthics for soil transmitted helminths during pregnancy. ( Bhutta, ZA; Haider, BA; Humayun, Q, 2009) |
"Albendazole (ABZ) is an effective therapeutic drug for adult T." | 1.91 | Treatment of pregnant mice with ABZ had no effect on the immune response of their offspring infected with Trichinella spiralis. ( Cao, X; Fan, S; Huang, H; Jiang, Y; Lu, H; Ma, R; Niu, T; Quan, Y; Shi, C; Wang, C; Wang, J; Wang, N; Wang, Y; Yang, G; Yang, W; Zeng, Y; Zhu, Z; Zou, B, 2023) |
"Albendazole has been found more efficient in reducing EPG of helminths in both parity animals as compared to levamisole-treated animals while the cost-benefit ratio of levamisole was greater than albendazole." | 1.48 | Anthelmintic Drugs: Their Efficacy and Cost-Effectiveness in Different Parity Cattle. ( Akbar, H; Ali, MS; Ashraf, K; Ijaz, M; Rashid, I; Rashid, M; Saeed, K, 2018) |
"Albendazole was not used." | 1.39 | Hepatic hydatid disease requiring urgent treatment during pregnancy. ( Alper, A; Bilge, O; Emre, A; Erçetin, C; Güven, K; Iyibozkurt, C; Özden, I; Serin, K; Tekant, Y, 2013) |
"A cardiac hydatid cyst in pregnancy is a very rare condition." | 1.37 | A pericardial hydatid cyst and pregnancy. ( Altay, H; Erol, T; Tarim, E, 2011) |
"Albendazole has teratogenic effects attributed to its active metabolite albendazole sulphoxide." | 1.37 | Evaluation of potential embryo toxicity of albendazole sulphoxide in CF1 mice. ( Catalano, R; Dercole, J; Teruel, M, 2011) |
"We report a case of right ventricle hydatid cyst detected after syncopal attack in a pregnant woman by using echocardiography." | 1.35 | Hydatid cyst of the right ventricle in early pregnancy. ( Abbasi, A; Marzban, M; Sahebjam, M; Shirani, S; Soleimani, A, 2008) |
"Hydatid cyst is still an important disease." | 1.33 | Primary hydatid cyst of the brain during pregnancy. ( Etlik, O; Kiymaz, N; Yazici, T; Yilmaz, N, 2006) |
"Hydatid disease is primarily a disease of sheep and cattle." | 1.32 | Hepatic and splenic hydatid cyst during pregnancy: a case report. ( Can, D; Oztekin, O; Sanci, M; Tinar, S, 2003) |
"Cystic hydatid disease is a zoonotic infection of humans caused by infection with the larval stage of Echinococcus granulosus." | 1.32 | Review of surgical management of cystic hydatid disease in a resource limited setting: Turkana, Kenya. ( Cooney, RM; Flanagan, KP; Zehyle, E, 2004) |
"Neurocysticercosis is an infection of the central nervous system with the pork tapeworm's cysticercus." | 1.30 | Neurocysticercosis in pregnancy: a case initially diagnosed as eclampsia. ( Iannucci, TA; Suarez, VR, 1999) |
" There were no adverse effects of albendazole at a dosage of 10 or 15 mg/kg on developing embryos or fetuses when administered to presumed pregnant cows at various times in early gestation." | 1.29 | Safety of albendazole in developing bovine fetuses. ( Carakostas, MC; Colaianne, JJ; Freeman, JF; Page, SW; Theodorides, VJ, 1993) |
" Where lambs were weaned by removing ewes from the lambing paddock, administration of the CRC at weaning to lambs whose dams had also been treated with the CRC did not result in improved production when compared with lambs from ewes dosed with CRCs and treated after weaning according to the Wormkill program." | 1.29 | Effects of a controlled-release albendazole capsule on parasitism and production from grazing Merino ewes and lambs. ( Barger, IA; Rodden, BR; Steel, JW, 1993) |
"The possible correlations between embryotoxicity, plasma kinetics of toxic metabolites and covalent binding of metabolites to foetal tissues were studied using two drugs, albendazole and oxfendazole." | 1.27 | A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues. ( Benoit, E; Delatour, P; Garnier, F; Longin, C, 1984) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (4.55) | 18.7374 |
1990's | 15 (17.05) | 18.2507 |
2000's | 29 (32.95) | 29.6817 |
2010's | 30 (34.09) | 24.3611 |
2020's | 10 (11.36) | 2.80 |
Authors | Studies |
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Hendrixson, DT | 1 |
Smith, K | 1 |
Lasowski, P | 1 |
Callaghan-Gillespie, M | 1 |
Weber, J | 1 |
Papathakis, P | 1 |
Iversen, PO | 1 |
Koroma, AS | 1 |
Manary, MJ | 1 |
Aschale, Y | 1 |
Abebaw, A | 1 |
Atnaf, A | 1 |
Mengist, A | 1 |
Kassie, B | 1 |
Yihunie, W | 1 |
Cunningham, FG | 1 |
Twickler, DM | 1 |
Fan, S | 1 |
Wang, Y | 3 |
Ma, R | 1 |
Niu, T | 1 |
Zou, B | 1 |
Quan, Y | 1 |
Lu, H | 2 |
Zhu, Z | 1 |
Shi, C | 1 |
Yang, W | 1 |
Jiang, Y | 2 |
Cao, X | 2 |
Wang, J | 5 |
Huang, H | 2 |
Zeng, Y | 1 |
Wang, N | 1 |
Yang, G | 1 |
Wang, C | 4 |
Lau, R | 1 |
Chris, RB | 1 |
Phuong, MS | 1 |
Khatib, A | 1 |
Kopalakrishnan, S | 1 |
Bhasker, S | 1 |
Raheel, H | 1 |
Lecce, C | 1 |
Yegorov, S | 1 |
Mishra, S | 1 |
Boggild, AK | 1 |
Nguépy Keubo, FR | 1 |
Mboua, PC | 1 |
Djifack Tadongfack, T | 1 |
Fokouong Tchoffo, E | 1 |
Tasson Tatang, C | 1 |
Ide Zeuna, J | 1 |
Noupoue, EM | 1 |
Tsoplifack, CB | 1 |
Folefack, GO | 1 |
Kettani, M | 1 |
Bandelier, P | 1 |
Huo, J | 1 |
Li, H | 4 |
Yu, D | 1 |
Arulsamy, N | 1 |
AlAbbad, S | 1 |
Sardot, T | 1 |
Lekashvili, O | 1 |
Decato, D | 1 |
Lelj, F | 1 |
Alexander Ross, JB | 1 |
Rosenberg, E | 1 |
Nazir, H | 1 |
Muthuswamy, N | 1 |
Louis, C | 1 |
Jose, S | 1 |
Prakash, J | 1 |
Buan, MEM | 1 |
Flox, C | 1 |
Chavan, S | 1 |
Shi, X | 1 |
Kauranen, P | 1 |
Kallio, T | 1 |
Maia, G | 1 |
Tammeveski, K | 1 |
Lymperopoulos, N | 1 |
Carcadea, E | 1 |
Veziroglu, E | 1 |
Iranzo, A | 1 |
M Kannan, A | 1 |
Arunamata, A | 1 |
Tacy, TA | 1 |
Kache, S | 1 |
Mainwaring, RD | 1 |
Ma, M | 1 |
Maeda, K | 1 |
Punn, R | 1 |
Noguchi, S | 1 |
Hahn, S | 3 |
Iwasa, Y | 3 |
Ling, J | 2 |
Voccio, JP | 2 |
Kim, Y | 3 |
Song, J | 3 |
Bascuñán, J | 2 |
Chu, Y | 1 |
Tomita, M | 1 |
Cazorla, M | 1 |
Herrera, E | 1 |
Palomeque, E | 1 |
Saud, N | 1 |
Hoplock, LB | 1 |
Lobchuk, MM | 1 |
Lemoine, J | 1 |
Li, X | 10 |
Henson, MA | 1 |
Unsihuay, D | 1 |
Qiu, J | 1 |
Swaroop, S | 1 |
Nagornov, KO | 1 |
Kozhinov, AN | 1 |
Tsybin, YO | 1 |
Kuang, S | 1 |
Laskin, J | 1 |
Zin, NNINM | 1 |
Mohamad, MN | 1 |
Roslan, K | 1 |
Abdul Wafi, S | 1 |
Abdul Moin, NI | 1 |
Alias, A | 1 |
Zakaria, Y | 1 |
Abu-Bakar, N | 1 |
Naveed, A | 1 |
Jilani, K | 1 |
Siddique, AB | 1 |
Akbar, M | 1 |
Riaz, M | 1 |
Mushtaq, Z | 1 |
Sikandar, M | 1 |
Ilyas, S | 1 |
Bibi, I | 1 |
Asghar, A | 1 |
Rasool, G | 1 |
Irfan, M | 1 |
Li, XY | 1 |
Zhao, S | 1 |
Fan, XH | 1 |
Chen, KP | 1 |
Hua, W | 1 |
Liu, ZM | 1 |
Xue, XD | 1 |
Zhou, B | 1 |
Zhang, S | 2 |
Xing, YL | 1 |
Chen, MA | 1 |
Sun, Y | 1 |
Neradilek, MB | 1 |
Wu, XT | 1 |
Zhang, D | 2 |
Huang, W | 1 |
Cui, Y | 1 |
Yang, QQ | 1 |
Li, HW | 1 |
Zhao, XQ | 1 |
Hossein Rashidi, B | 1 |
Tarafdari, A | 1 |
Ghazimirsaeed, ST | 1 |
Shahrokh Tehraninezhad, E | 1 |
Keikha, F | 1 |
Eslami, B | 1 |
Ghazimirsaeed, SM | 1 |
Jafarabadi, M | 1 |
Silvani, Y | 1 |
Lovita, AND | 1 |
Maharani, A | 1 |
Wiyasa, IWA | 1 |
Sujuti, H | 1 |
Ratnawati, R | 1 |
Raras, TYM | 1 |
Lemin, AS | 1 |
Rahman, MM | 1 |
Pangarah, CA | 1 |
Kiyu, A | 1 |
Zeng, C | 2 |
Du, H | 1 |
Lin, D | 1 |
Jalan, D | 1 |
Rubagumya, F | 1 |
Hopman, WM | 1 |
Vanderpuye, V | 1 |
Lopes, G | 1 |
Seruga, B | 1 |
Booth, CM | 1 |
Berry, S | 1 |
Hammad, N | 1 |
Sajo, EA | 1 |
Okunade, KS | 1 |
Olorunfemi, G | 1 |
Rabiu, KA | 1 |
Anorlu, RI | 1 |
Xu, C | 2 |
Xiang, Y | 1 |
Xu, X | 1 |
Zhou, L | 2 |
Dong, X | 1 |
Tang, S | 1 |
Gao, XC | 1 |
Wei, CH | 1 |
Zhang, RG | 1 |
Cai, Q | 1 |
He, Y | 1 |
Tong, F | 1 |
Dong, JH | 1 |
Wu, G | 1 |
Dong, XR | 1 |
Tang, X | 1 |
Tao, F | 1 |
Xiang, W | 1 |
Zhao, Y | 2 |
Jin, L | 1 |
Tao, H | 1 |
Lei, Y | 1 |
Gan, H | 1 |
Huang, Y | 1 |
Chen, Y | 3 |
Chen, L | 3 |
Shan, A | 1 |
Zhao, H | 2 |
Wu, M | 2 |
Ma, Q | 1 |
Zhang, E | 1 |
Zhang, J | 3 |
Li, Y | 5 |
Xue, F | 1 |
Deng, L | 1 |
Liu, L | 2 |
Yan, Z | 2 |
Meng, J | 1 |
Chen, G | 2 |
Anastassiadou, M | 1 |
Bernasconi, G | 1 |
Brancato, A | 1 |
Carrasco Cabrera, L | 1 |
Greco, L | 1 |
Jarrah, S | 1 |
Kazocina, A | 1 |
Leuschner, R | 1 |
Magrans, JO | 1 |
Miron, I | 1 |
Nave, S | 1 |
Pedersen, R | 1 |
Reich, H | 1 |
Rojas, A | 1 |
Sacchi, A | 1 |
Santos, M | 1 |
Theobald, A | 1 |
Vagenende, B | 1 |
Verani, A | 1 |
Du, L | 1 |
Liu, X | 1 |
Ren, Y | 1 |
Li, J | 7 |
Li, P | 1 |
Jiao, Q | 1 |
Meng, P | 1 |
Wang, F | 2 |
Wang, YS | 1 |
Zhou, X | 2 |
Wang, W | 1 |
Wang, S | 2 |
Hou, J | 1 |
Zhang, A | 1 |
Lv, B | 1 |
Gao, C | 1 |
Pang, D | 1 |
Lu, K | 1 |
Ahmad, NH | 1 |
Wang, L | 1 |
Zhu, J | 2 |
Zhang, L | 2 |
Zhuang, T | 1 |
Tu, J | 1 |
Zhao, Z | 1 |
Qu, Y | 1 |
Yao, H | 1 |
Wang, X | 5 |
Lee, DF | 1 |
Shen, J | 3 |
Wen, L | 1 |
Huang, G | 2 |
Xie, X | 1 |
Zhao, Q | 1 |
Hu, W | 1 |
Zhang, Y | 4 |
Wu, X | 1 |
Lu, J | 2 |
Li, M | 1 |
Li, W | 2 |
Wu, W | 1 |
Du, F | 1 |
Ji, H | 1 |
Yang, X | 2 |
Xu, Z | 1 |
Wan, L | 1 |
Wen, Q | 1 |
Cho, CH | 1 |
Zou, C | 1 |
Xiao, Z | 1 |
Liao, J | 1 |
Su, X | 1 |
Bi, Z | 1 |
Su, Q | 1 |
Wei, Y | 2 |
Gao, Y | 2 |
Na, KJ | 1 |
Choi, H | 1 |
Oh, HR | 1 |
Kim, YH | 1 |
Lee, SB | 1 |
Jung, YJ | 1 |
Koh, J | 1 |
Park, S | 1 |
Lee, HJ | 1 |
Jeon, YK | 1 |
Chung, DH | 1 |
Paeng, JC | 1 |
Park, IK | 1 |
Kang, CH | 1 |
Cheon, GJ | 1 |
Kang, KW | 1 |
Lee, DS | 1 |
Kim, YT | 1 |
Pajuelo-Lozano, N | 1 |
Alcalá, S | 1 |
Sainz, B | 1 |
Perona, R | 1 |
Sanchez-Perez, I | 1 |
Logotheti, S | 1 |
Marquardt, S | 1 |
Gupta, SK | 1 |
Richter, C | 1 |
Edelhäuser, BAH | 1 |
Engelmann, D | 1 |
Brenmoehl, J | 1 |
Söhnchen, C | 1 |
Murr, N | 1 |
Alpers, M | 1 |
Singh, KP | 1 |
Wolkenhauer, O | 1 |
Heckl, D | 1 |
Spitschak, A | 1 |
Pützer, BM | 1 |
Liao, Y | 1 |
Cheng, J | 1 |
Kong, X | 1 |
Li, S | 1 |
Zhang, M | 4 |
Zhang, H | 1 |
Yang, T | 2 |
Dong, Y | 1 |
Xu, Y | 1 |
Yuan, Z | 1 |
Cao, J | 1 |
Zheng, Y | 1 |
Luo, Z | 1 |
Mei, Z | 1 |
Yao, Y | 1 |
Liu, Z | 2 |
Liang, C | 1 |
Yang, H | 1 |
Song, Y | 1 |
Yu, K | 1 |
Zhu, C | 1 |
Huang, Z | 1 |
Qian, J | 1 |
Ge, J | 1 |
Hu, J | 2 |
Wang, H | 2 |
Liu, Y | 4 |
Mi, Y | 1 |
Kong, H | 1 |
Xi, D | 1 |
Yan, W | 1 |
Luo, X | 1 |
Ning, Q | 1 |
Chang, X | 2 |
Zhang, T | 2 |
Wang, Q | 2 |
Rathore, MG | 1 |
Reddy, K | 1 |
Chen, H | 1 |
Shin, SH | 1 |
Ma, WY | 1 |
Bode, AM | 1 |
Dong, Z | 1 |
Mu, W | 1 |
Liu, C | 3 |
Gao, F | 1 |
Qi, Y | 1 |
Zhang, X | 4 |
Cai, X | 1 |
Ji, RY | 1 |
Hou, Y | 3 |
Tian, J | 2 |
Shi, Y | 1 |
Ying, S | 1 |
Tan, M | 1 |
Feng, G | 1 |
Kuang, Y | 1 |
Chen, D | 1 |
Wu, D | 3 |
Zhu, ZQ | 1 |
Tang, HX | 1 |
Shi, ZE | 1 |
Kang, J | 1 |
Liu, Q | 1 |
Qi, J | 2 |
Mu, J | 1 |
Cong, Z | 1 |
Chen, S | 2 |
Fu, D | 1 |
Li, Z | 2 |
Celestrin, CP | 1 |
Rocha, GZ | 1 |
Stein, AM | 1 |
Guadagnini, D | 1 |
Tadelle, RM | 1 |
Saad, MJA | 1 |
Oliveira, AG | 1 |
Bianconi, V | 1 |
Bronzo, P | 1 |
Banach, M | 1 |
Sahebkar, A | 1 |
Mannarino, MR | 1 |
Pirro, M | 1 |
Patsourakos, NG | 1 |
Kouvari, M | 1 |
Kotidis, A | 1 |
Kalantzi, KI | 1 |
Tsoumani, ME | 1 |
Anastasiadis, F | 1 |
Andronikos, P | 1 |
Aslanidou, T | 1 |
Efraimidis, P | 1 |
Georgiopoulos, A | 1 |
Gerakiou, K | 1 |
Grigoriadou-Skouta, E | 1 |
Grigoropoulos, P | 1 |
Hatzopoulos, D | 1 |
Kartalis, A | 1 |
Lyras, A | 1 |
Markatos, G | 1 |
Mikrogeorgiou, A | 1 |
Myroforou, I | 1 |
Orkopoulos, A | 1 |
Pavlidis, P | 1 |
Petras, C | 1 |
Riga, M | 1 |
Skouloudi, M | 1 |
Smyrnioudis, N | 1 |
Thomaidis, K | 1 |
Tsikouri, GE | 1 |
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Tumusiime, J | 1 |
Kizza, M | 4 |
Kabagenyi, J | 1 |
Nkurunungi, G | 1 |
Muhangi, L | 10 |
Webb, EL | 7 |
Muwanga, M | 11 |
Elliott, AM | 12 |
Ali, MS | 1 |
Saeed, K | 1 |
Rashid, I | 1 |
Ijaz, M | 1 |
Akbar, H | 1 |
Rashid, M | 1 |
Ashraf, K | 1 |
Persichino, JG | 1 |
Miller, LG | 1 |
Ridler, AL | 1 |
Miller, CM | 2 |
Leathwick, DM | 2 |
Ganesh, S | 1 |
Garland, CB | 1 |
Bruce, HM | 1 |
Gyorkos, TW | 3 |
St-Denis, K | 1 |
Erçetin, C | 1 |
Özden, I | 1 |
Iyibozkurt, C | 1 |
Güven, K | 1 |
Serin, K | 1 |
Bilge, O | 1 |
Tekant, Y | 1 |
Alper, A | 1 |
Emre, A | 1 |
Bhattacharyya, SK | 1 |
Bhattacharya, S | 1 |
Alam, H | 1 |
Patua, B | 1 |
Chattopadhyay, P | 1 |
Ndibazza, J | 8 |
Nampijja, M | 7 |
Apule, B | 2 |
Lule, S | 2 |
Kizito, D | 6 |
Kakande, M | 1 |
Jones, FM | 2 |
Fitzsimmons, CM | 1 |
Rodrigues, LC | 2 |
Dunne, DW | 2 |
Mofid, LS | 2 |
Casapía, M | 1 |
Montresor, A | 3 |
Rahme, E | 1 |
Fraser, WD | 1 |
Marquis, GS | 1 |
Vercruysse, J | 1 |
Allen, LH | 1 |
Haider, BA | 2 |
Humayun, Q | 2 |
Bal, M | 1 |
Sahu, PK | 1 |
Mandal, N | 1 |
Satapathy, AK | 1 |
Ranjit, M | 1 |
Kar, SK | 1 |
Mentzer, AJ | 1 |
Smits, G | 1 |
van der Klis, FR | 1 |
Henao-Martínez, AF | 1 |
Madinger, N | 1 |
Scholes, SF | 1 |
Reichel, R | 1 |
Willmington, J | 1 |
Daniel, R | 1 |
Soleimani, A | 1 |
Sahebjam, M | 1 |
Marzban, M | 1 |
Shirani, S | 1 |
Abbasi, A | 1 |
Ndyomugyenyi, R | 1 |
Kabatereine, N | 2 |
Olsen, A | 1 |
Magnussen, P | 1 |
Liabsuetrakul, T | 1 |
Chaikongkeit, P | 1 |
Korviwattanagarn, S | 1 |
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Hanvattanakul, C | 1 |
Kongkitkul, P | 1 |
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Mihrshahi, S | 2 |
Casey, GJ | 2 |
Phuc, TQ | 2 |
Thach, DT | 1 |
Tien, NT | 2 |
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Phu, LB | 1 |
Caruana, SR | 1 |
Thach, TD | 1 |
Asnis, D | 1 |
Kazakov, J | 1 |
Toronjadze, T | 1 |
Bern, C | 1 |
Garcia, HH | 1 |
McAuliffe, I | 1 |
Bishop, H | 1 |
Lee, L | 1 |
Grossmann, R | 1 |
Garcia, MA | 1 |
Di John, D | 1 |
Akishule, D | 2 |
Kiggundu, M | 1 |
Ameke, C | 2 |
Oweka, J | 1 |
Kizindo, R | 3 |
Duong, T | 1 |
Kleinschmidt, I | 1 |
Pallua, K | 1 |
Putz, G | 1 |
Mitterschiffthaler, G | 1 |
Brezinka, C | 1 |
Biebl, M | 1 |
Paal, P | 1 |
Moliner, JV | 1 |
Valverde, AG | 1 |
Sorolla, JM | 1 |
Smith, JL | 1 |
Brooker, S | 2 |
Mawa, PA | 3 |
Namatovu, A | 1 |
Kyosiimire-Lugemwa, J | 2 |
Nanteza, B | 1 |
Woodburn, PW | 1 |
Akello, M | 1 |
Lyadda, N | 1 |
Bukusuba, J | 1 |
Kihembo, M | 2 |
Nabulime, J | 1 |
Namujju, PB | 3 |
Tweyongyere, R | 2 |
Whitworth, JA | 4 |
Ngom-wegi, S | 1 |
Tumusime, J | 1 |
Fitzsimmons, C | 1 |
Teruel, M | 1 |
Dercole, J | 1 |
Catalano, R | 1 |
Erol, T | 1 |
Altay, H | 1 |
Tarim, E | 1 |
Mawa, P | 1 |
Acevedo-Ramírez, PM | 1 |
Quiroz-Romero, H | 1 |
Cruz-Mendoza, I | 1 |
Ulloa-Arvizu, R | 1 |
Ibarra-Velarde, F | 1 |
Voigt, K | 1 |
Scheuerle, M | 1 |
Hamel, D | 1 |
Pfister, K | 1 |
Nkurunziza, P | 1 |
Kaleebu, P | 1 |
Novobilský, A | 1 |
Averpil, HB | 1 |
Höglund, J | 1 |
Urassa, DP | 1 |
Nystrom, L | 1 |
Carlsted, A | 1 |
Rutebarika, D | 1 |
Oduru, G | 1 |
Naniima, P | 1 |
Tweyongere, R | 1 |
Alcock, KJ | 1 |
Dupouy-Camet, J | 1 |
Kociecka, W | 1 |
Bruschi, F | 1 |
Bolas-Fernandez, F | 1 |
Pozio, E | 1 |
Allen, HE | 1 |
Crompton, DW | 1 |
de Silva, N | 1 |
LoVerde, PT | 1 |
Olds, GR | 1 |
Capece, BP | 2 |
Navarro, M | 2 |
Arcalis, T | 1 |
Castells, G | 2 |
Toribio, L | 1 |
Perez, F | 2 |
Carretero, A | 2 |
Ruberte, J | 2 |
Arboix, M | 3 |
Cristòfol, C | 3 |
Teruel, MT | 1 |
Felipe, AE | 1 |
Solana, HD | 1 |
Sallovitz, JM | 1 |
Lanusse, CE | 1 |
Can, D | 1 |
Oztekin, O | 2 |
Tinar, S | 1 |
Sanci, M | 1 |
Schellenberg, RS | 1 |
Tan, BJ | 1 |
Irvine, JD | 1 |
Stockdale, DR | 1 |
Gajadhar, AA | 1 |
Serhir, B | 1 |
Botha, J | 1 |
Armstrong, CA | 1 |
Woods, SA | 1 |
Blondeau, JM | 1 |
McNab, TL | 1 |
Gyapong, JO | 1 |
Chinbuah, MA | 1 |
Gyapong, M | 1 |
Cooney, RM | 1 |
Flanagan, KP | 1 |
Zehyle, E | 1 |
Auer, H | 3 |
Aspöck, H | 2 |
Quigley, MA | 3 |
Oweka-Onyee, J | 1 |
Shrimpton, R | 1 |
Dalmiya, N | 1 |
Darnton-Hill, I | 1 |
Gross, R | 1 |
Nkurunziza, PM | 1 |
Belisle, JT | 1 |
Yilmaz, N | 1 |
Kiymaz, N | 1 |
Etlik, O | 1 |
Yazici, T | 1 |
Atkinson, DS | 1 |
Haack, NA | 1 |
Alexander, RA | 1 |
Oliver, AM | 1 |
Waghorn, TS | 1 |
Potter, JF | 1 |
Sutherland, IA | 1 |
Morison, L | 1 |
Delatour, P | 2 |
Garnier, F | 1 |
Benoit, E | 1 |
Longin, C | 1 |
Parish, RC | 1 |
Gyurik, RJ | 1 |
Mezo-Menéndez, M | 1 |
Díez-Baños, P | 1 |
Morrondo-Pelayo, P | 1 |
Díez-Baños, N | 1 |
Golaszewski, T | 1 |
Susani, M | 1 |
Golaszewski, S | 1 |
Sliutz, G | 1 |
Bischof, G | 1 |
Kollaritsch, H | 1 |
Jüptner, J | 1 |
Theodorides, VJ | 1 |
Carakostas, MC | 1 |
Colaianne, JJ | 1 |
Freeman, JF | 1 |
Page, SW | 1 |
Liu, LX | 1 |
Weller, PF | 1 |
Horton, J | 1 |
Barger, IA | 1 |
Steel, JW | 1 |
Rodden, BR | 1 |
Gatongi, PM | 1 |
Scott, ME | 1 |
Ranjan, S | 1 |
Gathuma, JM | 1 |
Munyua, WK | 1 |
Cheruiyot, H | 1 |
Prichard, RK | 1 |
Franquelo, C | 1 |
Valladares, JE | 1 |
Filice, C | 1 |
Brunetti, E | 1 |
van Vliet, W | 1 |
Scheele, F | 1 |
Sibinga-Mulder, L | 1 |
Dekker, GA | 1 |
Al-Qudah, KM | 1 |
Sharif, LA | 1 |
Al-Rawashdeh, OF | 1 |
Al-Ani, FK | 1 |
Suarez, VR | 1 |
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Cowden, J | 1 |
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Pérez, R | 1 |
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Garcia, F | 1 |
Montes, H | 1 |
Soetkino, R | 1 |
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Khallaayoune, K | 1 |
Stromberg, BE | 1 |
Ward, JK | 1 |
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Parkhurst, AM | 1 |
Berthelsen, J | 1 |
Nelson, MJ | 1 |
Wetzel, H | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Randomized Control Trial of the Use of Supplementary Food and Measures to Control Inflammation in Malnourished Pregnant Women to Improve Birth Outcomes[NCT03079388] | 1,489 participants (Actual) | Interventional | 2017-02-27 | Completed | |||
S. Japonicum and Pregnancy Outcomes: A Randomized, Double Blind, Placebo Controlled Trial (RCT)[NCT00486863] | Phase 2 | 370 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
Activity of Mefloquine Against Urinary Schistosomiasis[NCT01132248] | Phase 2 | 65 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
Postpartum Deworming: Improving Breastfeeding and Optimizing Infant Growth[NCT01748929] | Phase 4 | 1,010 participants (Actual) | Interventional | 2014-02-24 | Completed | ||
Alternative Chemotherapies for Lymphatic Filariasis (LF) Treatment and Elimination in Africa [Cote d'Ivoire][NCT02974049] | 189 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Hemoglobin concentration in a venous blood sample collected at 14 and 32 weeks gestation was measured using a multi-analyte analyzer. Each participant's change in hemoglobin concentration between the two timepoints was determined, and the mean and standard deviation for each group calculated. (NCT00486863)
Timeframe: 14 weeks and 32 weeks gestation
Intervention | grams/deciliter (Mean) |
---|---|
Placebo Control at 12-16 Weeks Gestation | -0.42 |
Praziquantel at 12-16 Weeks Gestation | -0.44 |
Maternal fat stores were measured by thigh skinfold thickness obtained using a Holtain skinfold caliper. The thickness increase from 14 to 32 weeks was determined for each participant, and the mean and standard deviation calculated. (NCT00486863)
Timeframe: 14 and 32 weeks gestation
Intervention | millimeters (Mean) |
---|---|
Placebo Control at 12-16 Weeks Gestation | 0.08 |
Praziquantel at 12-16 Weeks Gestation | 0.08 |
Maternal weight gain was assessed by measuring participants' weight in kilograms. The weight increase from 14 to 32 weeks was determined for each participant, and the mean and standard deviation calculated. (NCT00486863)
Timeframe: 14 and 32 weeks gestation
Intervention | kilograms (Mean) |
---|---|
Placebo Control at 12-16 Weeks Gestation | 0.33 |
Praziquantel at 12-16 Weeks Gestation | 0.32 |
Birth weight was collected for live infants at the time of delivery by a trained midwife, or within 24 hours of delivery for participants who chose to deliver at home with a helot, a birth attendant without formal training. (NCT00486863)
Timeframe: Within 24 hours of delivery.
Intervention | kilograms (Mean) |
---|---|
Placebo Control at 12-16 Weeks Gestation | 2.85 |
Praziquantel at 12-16 Weeks Gestation | 2.85 |
To assess total body iron, one needs to assess the storage compartment, which will contain sequestered iron, and the functional compartment, which represents bioavailable iron. Body iron status is defined by the two laboratory measurements that reflect these compartments, ferritin and serum transferrin receptor. The serum transferrin receptor:ferritin ratio has been shown in quantitative phlebotomy studies to provide an accurate assessment of total body iron over the entire range of status. At 14 and 32 weeks gestation, a blood sample was collected for assessment of total body iron by determination of the transferrin receptor:ferritin ratio. Each participant's change in ratio was calculated, and the median and interquartile range were determined for each group. (NCT00486863)
Timeframe: 14 weeks and 32 weeks gestation
Intervention | ratio (Median) |
---|---|
Placebo Control at 12-16 Weeks Gestation | 0.0 |
Praziquantel at 12-16 Weeks Gestation | 0.0 |
Anemia of inflammation was assessed via maternal urine hepcidin levels. In response to inflammation, elevated serum levels of hepcidin is synthesized. Hepcidin causes sequestration of iron from bio-available forms to storage forms such as ferritin and decreases intestinal absorption of iron. Hepcidin was measured in participants' urine at 32 weeks gestation. (NCT00486863)
Timeframe: 32 weeks gestation
Intervention | nanograms/milliliter (Median) |
---|---|
Placebo Control at 12-16 Weeks Gestation | 2.58 |
Praziquantel at 12-16 Weeks Gestation | 3.38 |
Abortion was defined by the protocol as bleeding followed by fetal loss as supported by ultrasound before 20 weeks gestation. Abortion was an important safety outcome measure due to the fact that abortion would occur closer to the time of dosing than miscarriage or stillbirth. Participants were observed in hospital for 24 hours after dosing and asked to return for any bleeding at any time. (NCT00486863)
Timeframe: After dosing and before 20 weeks gestation
Intervention | participants (Number) |
---|---|
Placebo Control at 12-16 Weeks Gestation | 0 |
Praziquantel at 12-16 Weeks Gestation | 0 |
Participants were observed in hospital for 24 hours after dosing for serious adverse events. Serious adverse events included any untoward medical occurrence that resulted in death; was life threatening; was a persistent/significant disability/incapacity; required in-patient hospitalization or prolongation thereof (for reasons other than the 24-hour observation period); resulted in a congenital anomaly/birth defect; or may have jeopardized the participant, or required intervention to prevent one of these outcomes. (NCT00486863)
Timeframe: Within 24 hours of dosing
Intervention | participants (Number) |
---|---|
Placebo Control at 12-16 Weeks Gestation | 0 |
Praziquantel at 12-16 Weeks Gestation | 0 |
The newborn was examined by the midwife at delivery and within 2-6 days of delivery to assess the presence of congenital anomalies and well-being. The newborn was also examined by study pediatrician at 28 days of life. (NCT00486863)
Timeframe: At delivery, within 2-6 days of delivery, and at 28 days
Intervention | participants (Number) |
---|---|
Placebo Control at 12-16 Weeks Gestation | 1 |
Praziquantel at 12-16 Weeks Gestation | 1 |
Each participant was followed until delivery to record if the outcome of the pregnancy was a live birth. Live births were defined as the complete expulsion or extraction from its mother of a product of conception, irrespective of the duration of the pregnancy, which, after such separation, breathes or shows any other evidence of life such as heartbeat, umbilical cord pulsation, or definite movement of voluntary muscles, whether the umbilical cord had been cut or the placenta was attached. (NCT00486863)
Timeframe: At delivery
Intervention | participants (Number) |
---|---|
Placebo Control at 12-16 Weeks Gestation | 181 |
Praziquantel at 12-16 Weeks Gestation | 181 |
Participants were assessed for the presence of pre-eclampsia at both the 22 and 32 week visits. Pre-eclampsia was defined by the presence of proteinurea (2+ protein on urine dipstick) and a single diastolic blood pressure reading of 100 millimiters of mercury (mm Hg) or above OR more than one reading, four hours apart, of 90 mm Hg or above. (NCT00486863)
Timeframe: 22 weeks and 32 weeks
Intervention | participants (Number) |
---|---|
Placebo Control at 12-16 Weeks Gestation | 0 |
Praziquantel at 12-16 Weeks Gestation | 0 |
Parasitologic response to treatment was evaluated by counting S. japonicum eggs per gram of stool at screening and again at 22 weeks gestation. Success of treatment was pre-specified as greater than 90 percent reduction in egg count from screening to 22 weeks gestation. (NCT00486863)
Timeframe: Screening and 22 weeks gestation
Intervention | participants (Number) |
---|---|
Placebo Control at 12-16 Weeks Gestation | 92 |
Praziquantel at 12-16 Weeks Gestation | 157 |
Since pregnancy is associated with increased cytochrome P450 activity and physiologic changes in the gastrointestinal tract that tend to reduce drug absorption, praziquantel pharmacokinetics may be affected by pregnancy. Thus, the metabolite-to-parent drug ratio may serve as a differential marker to help determine if variability in drug exposure following oral administration during pregnancy is due to altered metabolism or drug absorption. Samples that were collected from subjects who were randomized to receive praziquantel were analyzed for praziquantel and 4-hydroxy praziquantel concentrations. Assays were performed using high performance liquid chromatography-electrospray mass spectrometry in the University of California at San Diego Pediatric Clinical Pharmacology Laboratory. Descriptive statistics were obtained for concentrations at each of the four sparse sampling timepoints. (NCT00486863)
Timeframe: 4.5 and 8 hours after the first praziquantel dose (subjects assigned to an even study number) or 6 and 10 hours after the first praziquantel dose (subjects assigned to an odd study number).
Intervention | ng/ml (Median) | |||
---|---|---|---|---|
4.5 Hours, n=50 | 6 Hours, n=49 | 8 Hours, n=50 | 10 Hours, n=49 | |
Praziquantel at 12-16 Weeks Gestation | 4020.1 | 4590.8 | 5373.7 | 4304.1 |
To assess total body iron, the serum transferrin receptor:ferritin ratio was assessed in the infant. At delivery, a heel stick blood sample and a cord blood sample were collected for assessment of total body iron by determination of the transferrin receptor:ferritin ratio. (NCT00486863)
Timeframe: 0-6 days after delivery.
Intervention | ratio (Median) | |
---|---|---|
Cord Blood | Heel Stick | |
Placebo Control at 12-16 Weeks Gestation | 1.76 | 0.00 |
Praziquantel at 12-16 Weeks Gestation | 1.33 | 0.00 |
Toxicity to maternal kidney and liver was assessed by laboratory parameters collected just before and 24 hours after dosing. Specifically, blood was drawn just before the dose at 12-16 weeks gestation to determine baseline blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and bilirubin. Blood was then drawn 24 hours after the second part of the split dose and before discharge from the hospital to assess any changes in these parameters. Any values that were 1.1 times the upper limit of normal or greater for the parameter were considered abnormal. (NCT00486863)
Timeframe: Just before and 24 hours after dosing
Intervention | participants (Number) | ||||
---|---|---|---|---|---|
Blood Urea Nitrogen (BUN) Abnormal | Creatinine Abnormal | Aspartate Aminotransferase (AST) Abnormal | Alanine Aminotransferase (ALT) Abnormal | Bilirubin Abnormal | |
Placebo Control at 12-16 Weeks Gestation | 127 | 23 | 8 | 13 | 127 |
Praziquantel at 12-16 Weeks Gestation | 137 | 39 | 9 | 10 | 137 |
Toxicity to maternal bone marrow, kidney, and liver was assessed by laboratory parameters collected just before and 24 hours after dosing. Specifically, blood was drawn just before the dose at 12-16 weeks gestation to determine baseline complete blood count, including white blood count (WBC), platelets, and hemoglobin. Blood was then drawn 24 hours after the second part of the split dose and before discharge from the hospital to assess any changes in these parameters. White blood count was abnormal at or above 10,800 or at or below 3500 cells/square millimeter (sq mm), platelets were abnormal at or below 140,000 cells/sq mm, and hemoglobin was abnormal at or below 10.9 grams/deciliter (g/dL). (NCT00486863)
Timeframe: Just before and 24 hours after dosing
Intervention | participants (Number) | ||
---|---|---|---|
White Blood Cell Abnormal | Platelets Abnormal | Hemoglobin Abnormal | |
Placebo Control at 12-16 Weeks Gestation | 69 | 3 | 54 |
Praziquantel at 12-16 Weeks Gestation | 60 | 0 | 56 |
Two plasma samples were collected during the overnight hospitalization from approximately 200 subjects that remained at the time of study modification to incorporate PK studies. Subjects had samples collected based on one of two sample collection strategies: 4.5 and 8 hr after the first praziquantel dose or 6 and 10 hr after the first praziquantel dose. Subjects randomized to an even study number were assigned to the 4.5 and 8 hour schedule. Subjects randomized to an odd study number were assigned to the 6 and 10 hour schedule. Samples only from subjects randomized to receive praziquantel were analyzed for praziquantel. Samples drawn from subjects randomized to the control group were not analyzed. Praziquantel concentrations (ng/ml) were assayed using high performance liquid chromatography-electrospray mass spectrometry in the University of California at San Diego Pediatric Clinical Pharmacology Laboratory. (NCT00486863)
Timeframe: 4.5 and 8 hours after the first praziquantel dose (subjects assigned to an even study number) or 6 and 10 hours after the first praziquantel dose (subjects assigned to an odd study number).
Intervention | ng/mL (Median) | |||
---|---|---|---|---|
4.5 Hours, n=50 | 6 Hours, n=49 | 8 Hours, n=50 | 10 Hours, n=49 | |
Praziquantel at 12-16 Weeks Gestation | 814.7 | 945.2 | 687.8 | 422.2 |
12 reviews available for albendazole and Pregnancy
Article | Year |
---|---|
Treatment of soil-transmitted helminth infections in pregnancy: a systematic review and meta-analysis of maternal outcomes.
Topics: Albendazole; Animals; Anthelmintics; Female; Helminthiasis; Helminths; Humans; Pregnancy; Soil; Trav | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Effect of mass deworming with antihelminthics for soil-transmitted helminths during pregnancy.
Topics: Albendazole; Anemia, Iron-Deficiency; Anthelmintics; Bias; Female; Helminthiasis; Humans; Intestinal | 2021 |
Effect of mass deworming with antihelminthics for soil-transmitted helminths during pregnancy.
Topics: Albendazole; Anemia, Iron-Deficiency; Anthelmintics; Bias; Female; Helminthiasis; Humans; Intestinal | 2021 |
Effect of mass deworming with antihelminthics for soil-transmitted helminths during pregnancy.
Topics: Albendazole; Anemia, Iron-Deficiency; Anthelmintics; Bias; Female; Helminthiasis; Humans; Intestinal | 2021 |
Effect of mass deworming with antihelminthics for soil-transmitted helminths during pregnancy.
Topics: Albendazole; Anemia, Iron-Deficiency; Anthelmintics; Bias; Female; Helminthiasis; Humans; Intestinal | 2021 |
Systematic review of exposure to albendazole or mebendazole during pregnancy and effects on maternal and child outcomes, with particular reference to exposure in the first trimester.
Topics: Albendazole; Anthelmintics; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Mebenda | 2019 |
Effect of administration of antihelminthics for soil-transmitted helminths during pregnancy.
Topics: Albendazole; Anemia, Iron-Deficiency; Anthelmintics; Female; Helminthiasis; Humans; Iron Compounds; | 2015 |
Effect of administration of antihelminthics for soil transmitted helminths during pregnancy.
Topics: Albendazole; Anemia, Iron-Deficiency; Anthelmintics; Female; Helminthiasis; Humans; Iron Compounds; | 2009 |
Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review.
Topics: Adolescent; Adult; Aged; Albendazole; Anemia; Anthelmintics; Child; Child, Preschool; Female; Hemogl | 2010 |
Opinion on the diagnosis and treatment of human trichinellosis.
Topics: Adult; Albendazole; Animals; Anthelmintics; Child; Female; Humans; Pregnancy; Randomized Controlled | 2002 |
New policies for using anthelmintics in high risk groups.
Topics: Albendazole; Animals; Anthelmintics; Female; Humans; Infant; Lactation; Mebendazole; Pregnancy; Risk | 2002 |
[Nosology and epidemiology of human toxocarosis--the recent situation in Austria].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Albendazole; Animals; Anthelmin | 2004 |
Strongyloidiasis and other intestinal nematode infections.
Topics: Adult; Albendazole; Animals; Dogs; Female; Humans; Intestinal Diseases, Parasitic; Ivermectin; Male; | 1993 |
Mebendazole and albendazole treatment of geohelminth infections in children and pregnant women.
Topics: Adolescent; Albendazole; Animals; Anthelmintics; Antinematodal Agents; Child; Child, Preschool; Fema | 2000 |
21 trials available for albendazole and Pregnancy
Article | Year |
---|---|
A novel intervention combining supplementary food and infection control measures to improve birth outcomes in undernourished pregnant women in Sierra Leone: A randomized, controlled clinical effectiveness trial.
Topics: Adolescent; Adult; Albendazole; Anti-Bacterial Agents; Antiprotozoal Agents; Azithromycin; Dysbiosis | 2021 |
Hookworm re-infection rate and efficacy of single-dose albendazole among pregnant women in Debre Elias District, Northwest Ethiopia: A single-arm trial.
Topics: Albendazole; Ancylostomatoidea; Animals; Anthelmintics; Cross-Sectional Studies; Ethiopia; Female; H | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Effects of treating helminths during pregnancy and early childhood on risk of allergy-related outcomes: Follow-up of a randomized controlled trial.
Topics: Albendazole; Anthelmintics; Asthma; Child; Child, Preschool; Double-Blind Method; Female; Follow-Up | 2017 |
Production responses and cost-benefit of long-acting pre-lambing anthelmintic treatment of yearling ewes in two commercial flocks in New Zealand.
Topics: Albendazole; Animals; Anthelmintics; Cobalt; Cost-Benefit Analysis; Delayed-Action Preparations; Fem | 2019 |
Maternal hookworm modifies risk factors for childhood eczema: results from a birth cohort in Uganda.
Topics: Albendazole; Anthelmintics; Child, Preschool; Cohort Studies; Double-Blind Method; Eczema; Female; H | 2014 |
Maternal Deworming Research Study (MADRES) protocol: a double-blind, placebo-controlled randomised trial to determine the effectiveness of deworming in the immediate postpartum period.
Topics: Adult; Albendazole; Anthelmintics; Breast Feeding; Cost-Benefit Analysis; Double-Blind Method; Femal | 2015 |
The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a randomised controlled trial.
Topics: Adult; Albendazole; Animals; Anthelmintics; Antibodies, Helminth; Antibody Formation; Female; Helmin | 2017 |
Efficacy of ivermectin and albendazole alone and in combination for treatment of soil-transmitted helminths in pregnancy and adverse events: a randomized open label controlled intervention trial in Masindi district, western Uganda.
Topics: Abortion, Spontaneous; Albendazole; Antiparasitic Agents; Birth Weight; Congenital Abnormalities; Dr | 2008 |
Effects of deworming during pregnancy on maternal and perinatal outcomes in Entebbe, Uganda: a randomized controlled trial.
Topics: Albendazole; Anemia; Animals; Anthelmintics; Birth Weight; Double-Blind Method; Female; Helminthiasi | 2010 |
Effect of single-dose anthelmintic treatment during pregnancy on an infant's response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled trial.
Topics: Adult; Albendazole; Anthelmintics; Communicable Diseases; Dose-Response Relationship, Drug; Double-B | 2011 |
Anthelminthic treatment during pregnancy is associated with increased risk of infantile eczema: randomised-controlled trial results.
Topics: Adult; Albendazole; Anthelmintics; Dermatitis, Atopic; Double-Blind Method; Female; Helminthiasis; H | 2011 |
Treatment with anthelminthics during pregnancy: what gains and what risks for the mother and child?
Topics: Albendazole; Ancylostomatoidea; Anemia; Animals; Anthelmintics; Benzimidazoles; Birth Weight; Child; | 2011 |
The effect of anthelmintic treatment during pregnancy on HIV plasma viral load: results from a randomized, double-blind, placebo-controlled trial in Uganda.
Topics: Adult; Albendazole; Anthelmintics; Cohort Studies; Double-Blind Method; Female; Helminthiasis; HIV I | 2012 |
The field evaluation of albendazole and triclabendazole efficacy against Fasciola hepatica by coproantigen ELISA in naturally infected sheep.
Topics: Albendazole; Animals; Anthelmintics; Antibodies, Helminth; Antigens, Helminth; Benzimidazoles; Bioma | 2012 |
Effectiveness of routine antihelminthic treatment on anaemia in pregnancy in Rufiji District, Tanzania: a cluster randomised controlled trial.
Topics: Adult; Albendazole; Anemia; Anemia, Iron-Deficiency; Anthelmintics; Antimalarials; Cluster Analysis; | 2011 |
Impact of anthelminthic treatment in pregnancy and childhood on immunisations, infections and eczema in childhood: a randomised controlled trial.
Topics: Adult; Albendazole; Anthelmintics; Child, Preschool; Double-Blind Method; Eczema; Female; Helminthia | 2012 |
Placental and fetal toxicity of albendazole sulphoxide in Wistar rats.
Topics: Abnormalities, Multiple; Administration, Oral; Albendazole; Animals; Anthelmintics; Dose-Response Re | 2003 |
A randomised controlled trial of the effects of albendazole in pregnancy on maternal responses to mycobacterial antigens and infant responses to Bacille Calmette-Guérin (BCG) immunisation [ISRCTN32849447].
Topics: Adult; Albendazole; Animals; Antigens, Bacterial; BCG Vaccine; Double-Blind Method; Female; Helminth | 2005 |
The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and e
Topics: Albendazole; Animals; Antiparasitic Agents; Child; Double-Blind Method; Female; Helminthiasis; Helmi | 2007 |
Anthelminthic treatment and haemoglobin concentrations during pregnancy.
Topics: Adolescent; Adult; Albendazole; Anemia; Anthelmintics; Dietary Supplements; Female; Folic Acid; Helm | 2000 |
56 other studies available for albendazole and Pregnancy
Article | Year |
---|---|
Neurocysticercosis Complicating Pregnancy.
Topics: Albendazole; Anthelmintics; Female; Headache; Humans; Hydrocephalus; Infant, Newborn; Neurocysticerc | 2022 |
Treatment of pregnant mice with ABZ had no effect on the immune response of their offspring infected with Trichinella spiralis.
Topics: Albendazole; Animals; Cytokines; Female; Humans; Immunity; Mice; Pregnancy; Trichinella spiralis; Tr | 2023 |
A 28-Year-Old Pregnant Woman With a Lung Abscess and Complicated Pleural Effusion.
Topics: Adult; Albendazole; Anthelmintics; Diagnosis, Differential; Drainage; Echinococcosis, Pulmonary; Fem | 2020 |
Unusual case of lagochilascariasis with breast involvement: the first case report in pregnancy.
Topics: Abscess; Adolescent; Adult; Albendazole; Animals; Anti-Bacterial Agents; Antiparasitic Agents; Ascar | 2020 |
Effect of Lymphatic Filariasis and Hookworm Infection on Pregnancy Course and Outcome in Women Living in the Democratic Republic of the Congo.
Topics: Adolescent; Adult; Aged; Albendazole; Anthelmintics; Antigens, Helminth; Democratic Republic of the | 2021 |
Foetal outcomes after exposure to albendazole in early pregnancy.
Topics: Adult; Albendazole; Anthelmintics; Case-Control Studies; Female; Humans; Pregnancy; Pregnancy Outcom | 2017 |
Anthelmintic Drugs: Their Efficacy and Cost-Effectiveness in Different Parity Cattle.
Topics: Albendazole; Animals; Anthelmintics; Cattle; Cattle Diseases; Cost-Benefit Analysis; Fats; Feces; Fe | 2018 |
Pregnancy Screening and Monitoring of Albendazole Therapy for Neurocysticercosis.
Topics: Albendazole; Anthelmintics; Humans; Hygiene; Neurocysticercosis; Pregnancy; Tropical Medicine; Unite | 2018 |
Hepatic hydatid disease requiring urgent treatment during pregnancy.
Topics: Adult; Albendazole; Anastomosis, Surgical; Anticestodal Agents; Drainage; Echinococcosis, Hepatic; F | 2013 |
Dilemmas encountered while dealing a pregnancy complicated by pelvic Hydatid disease.
Topics: Adult; Albendazole; Anticestodal Agents; Cesarean Section; Dystocia; Echinococcosis; Female; Humans; | 2013 |
Maternal Infection Is a Risk Factor for Early Childhood Infection in Filariasis.
Topics: Adult; Aging; Albendazole; Antigens, Helminth; Cohort Studies; Diethylcarbamazine; Female; Filariasi | 2015 |
The Case for Maternal Postpartum Deworming.
Topics: Adolescent; Adult; Albendazole; Anthelmintics; Drug Administration Schedule; Female; Global Health; | 2017 |
Anemia During Pregnancy-The Enemies Within.
Topics: Administration, Oral; Adult; Albendazole; Anemia; Animals; Female; Hematocrit; Hemoglobins; Humans; | 2017 |
Malformations including hemimelia and amelia in sheep.
Topics: Albendazole; Animals; Anthelmintics; Ectromelia; Female; Mebendazole; Pregnancy; Sheep; Sheep Diseas | 2008 |
Hydatid cyst of the right ventricle in early pregnancy.
Topics: Abortion, Spontaneous; Adult; Albendazole; Cardiac Surgical Procedures; Combined Modality Therapy; E | 2008 |
Epidemiology and the effect of treatment of soil-transmitted helminthiasis in pregnant women in southern Thailand.
Topics: Adolescent; Adult; Albendazole; Ancylostomatoidea; Animals; Anthelmintics; Ascariasis; Ascaris lumbr | 2009 |
The effectiveness of 4 monthly albendazole treatment in the reduction of soil-transmitted helminth infections in women of reproductive age in Viet Nam.
Topics: Adolescent; Adult; Albendazole; Animals; Feces; Female; Fertilizers; Helminthiasis; Hookworm Infecti | 2009 |
Lessons learned from implementation of a demonstration program to reduce the burden of anemia and hookworm in women in Yen Bai Province, Viet Nam.
Topics: Adolescent; Adult; Albendazole; Anemia, Iron-Deficiency; Anthelmintics; Female; Folic Acid; Guidelin | 2009 |
Neurocysticercosis in the infant of a pregnant mother with a tapeworm.
Topics: Albendazole; Animals; Anthelmintics; Anti-Inflammatory Agents; Anticonvulsants; Carbamazepine; Dexam | 2009 |
Management of hepatic echinococcosis in pregnancy.
Topics: Adult; Albendazole; Cesarean Section; Diphenhydramine; Echinococcosis, Hepatic; Famotidine; Female; | 2010 |
[Loa loa meningoencephalitis secondary to treatment with mebendazol].
Topics: Adolescent; Albendazole; Animals; Anthelmintics; Brain Damage, Chronic; Central Nervous System Helmi | 2011 |
Evaluation of potential embryo toxicity of albendazole sulphoxide in CF1 mice.
Topics: Albendazole; Animals; Anthelmintics; Blastocyst; Embryo, Mammalian; Female; Humans; Male; Mice; Preg | 2011 |
A pericardial hydatid cyst and pregnancy.
Topics: Adult; Albendazole; Anthelmintics; Echinococcosis; Echinococcosis, Hepatic; Female; Heart Diseases; | 2011 |
Gastrointestinal nematodes in rotationally grazing ewes in the mountainous region of central Mexico.
Topics: Albendazole; Animals; Anthelmintics; Climate; Feces; Female; Gastrointestinal Diseases; Ivermectin; | 2013 |
[High perinatal mortality associated with triple anthelmintic resistance in a German sheep flock].
Topics: Abortion, Veterinary; Albendazole; Animals; Animals, Newborn; Anthelmintics; Diarrhea; Drug Resistan | 2012 |
Albendazole sulphoxide enantiomers in pregnant rats' embryo concentrations and developmental toxicity.
Topics: Abnormalities, Multiple; Administration, Oral; Albendazole; Animals; Anthelmintics; Bone and Bones; | 2003 |
Hepatic and splenic hydatid cyst during pregnancy: a case report.
Topics: Adult; Albendazole; Anthelmintics; Delivery, Obstetric; Diagnosis, Differential; Echinococcosis; Ech | 2003 |
An outbreak of trichinellosis due to consumption of bear meat infected with Trichinella nativa, in 2 northern Saskatchewan communities.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albendazole; Animals; Anti-Inflammatory Agents; Antinema | 2003 |
Inadvertent exposure of pregnant women to ivermectin and albendazole during mass drug administration for lymphatic filariasis.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adolescent; Adult; Albendazole; Child Developmen | 2003 |
Review of surgical management of cystic hydatid disease in a resource limited setting: Turkana, Kenya.
Topics: Abdomen; Adolescent; Adult; Aged; Albendazole; Anticestodal Agents; Child; Child, Preschool; Echinoc | 2004 |
Helminth infection during pregnancy and development of infantile eczema.
Topics: Albendazole; Anthelmintics; Eczema; Female; Helminthiasis; Humans; Infant; Infant, Newborn; Poisson | 2005 |
Micronutrient supplementation in pregnancy.
Topics: Albendazole; Anthelmintics; Birth Weight; Female; Humans; Infant Mortality; Infant, Newborn; Micronu | 2005 |
Primary hydatid cyst of the brain during pregnancy.
Topics: Adult; Albendazole; Antiprotozoal Agents; Brain; Echinococcosis; Female; Humans; Pregnancy; Pregnanc | 2006 |
Drenching adult ewes: implications of anthelmintic treatments pre- and post-lambing on the development of anthelmintic resistance.
Topics: Albendazole; Animal Husbandry; Animals; Anthelmintics; Antinematodal Agents; Drug Resistance; Feces; | 2006 |
Albendazole: worms and hydatid disease.
Topics: Albendazole; Anthelmintics; Benzimidazoles; Echinococcosis; Female; Humans; Nematode Infections; Pre | 1984 |
A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues.
Topics: Albendazole; Animals; Anthelmintics; Benzimidazoles; Embryo, Mammalian; Female; Kinetics; Microsomes | 1984 |
Albendazole : a comparison of relay embryotoxicity with embryotoxicity of individual metabolites.
Topics: Abnormalities, Drug-Induced; Albendazole; Animals; Anthelmintics; Benzimidazoles; Cattle; Chemical P | 1981 |
Faecal egg output, contamination of pastures and serum pepsinogen concentrations in heifers with natural gastrointestinal nematode infections in north-west Spain.
Topics: Albendazole; Animal Feed; Animals; Cattle; Cattle Diseases; Feces; Female; Gastrointestinal Diseases | 1995 |
A large hydatid cyst of the liver in pregnancy.
Topics: Adult; Albendazole; Echinococcosis, Hepatic; Female; Humans; Pregnancy; Pregnancy Complications, Par | 1995 |
Albendazole and pregnancy.
Topics: Adult; Albendazole; Echinococcosis, Hepatic; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy C | 1994 |
Safety of albendazole in developing bovine fetuses.
Topics: Administration, Oral; Albendazole; Animals; Cattle; Embryo, Mammalian; Embryonic and Fetal Developme | 1993 |
The use of antiprotozoan and anthelmintic drugs during pregnancy and contraindications.
Topics: Albendazole; Antimalarials; Drug Approval; Female; Humans; Infant, Newborn; Mutagens; Phenanthrenes; | 1993 |
Effects of a controlled-release albendazole capsule on parasitism and production from grazing Merino ewes and lambs.
Topics: Albendazole; Animals; Benzimidazoles; Capsules; Delayed-Action Preparations; Drug Resistance; Feces; | 1993 |
Effects of three nematode anthelmintic treatment regimes on flock performance of sheep and goats under extensive management in semi-arid Kenya.
Topics: Albendazole; Animals; Antinematodal Agents; Birth Weight; Desert Climate; Drug Administration Schedu | 1997 |
Disposition of netobimin, albendazole, and its metabolites in the pregnant rat: developmental toxicity.
Topics: Albendazole; Animals; Anthelmintics; Area Under Curve; Female; Guanidines; Pregnancy; Rats; Rats, Sp | 1997 |
Percutaneous drainage of hydatid cysts.
Topics: Albendazole; Child, Preschool; Drainage; Echinococcosis, Hepatic; Female; Humans; Pregnancy; Pregnan | 1998 |
Echinococcosis of the liver during pregnancy.
Topics: Adult; Albendazole; Anthelmintics; Echinococcosis, Hepatic; Emigration and Immigration; Female; Huma | 1995 |
Efficacy of closantel plus albendazole liquid suspension against natural infection of gastrointestinal parasites in camels.
Topics: Albendazole; Animals; Anthelmintics; Camelus; Drug Combinations; Feces; Female; Helminthiasis, Anima | 1999 |
Neurocysticercosis in pregnancy: a case initially diagnosed as eclampsia.
Topics: Adult; Albendazole; Anthelmintics; Brain Diseases; Cerebral Ventricles; Diagnosis, Differential; Ecl | 1999 |
Hookworm and anaemia prevalence.
Topics: Albendazole; Anemia; Anthelmintics; Comorbidity; Female; Hookworm Infections; Humans; Pregnancy; Pre | 2000 |
Echinococcosis of the spleen during pregnancy.
Topics: Abortion, Induced; Adult; Albendazole; Anthelmintics; Echinococcosis, Hepatic; Female; Humans; Lapar | 2001 |
Placental transfer of albendazole sulphoxide enantiomers in sheep.
Topics: Administration, Oral; Albendazole; Animals; Anthelmintics; Area Under Curve; Female; Fetus; Gestatio | 2002 |
Hydatid disease in pregnancy.
Topics: Adult; Albendazole; Anticestodal Agents; Echinococcosis, Hepatic; Female; Humans; Laparotomy; Pregna | 2002 |
Effects of an anthelmintic treatment programme on sheep productivity in the Middle Atlas, Morocco.
Topics: Albendazole; Animals; Female; Fenbendazole; Helminthiasis; Helminthiasis, Animal; Male; Morocco; Pre | 1992 |
Internal parasite levels and response to anthelmintic treatment by beef cows and calves.
Topics: Age Factors; Albendazole; Animals; Cattle; Cattle Diseases; Cestode Infections; Coccidiosis; Feces; | 1991 |
[Use of albendazole in pregnant cows. Field studies on its safety in usage].
Topics: Abnormalities, Drug-Induced; Albendazole; Animals; Anthelmintics; Benzimidazoles; Cattle; Cattle Dis | 1985 |