alatrofloxacin and Acquired-Immunodeficiency-Syndrome

alatrofloxacin has been researched along with Acquired-Immunodeficiency-Syndrome* in 1 studies

Trials

1 trial(s) available for alatrofloxacin and Acquired-Immunodeficiency-Syndrome

Article	Year
Oral bioavailability and pharmacokinetics of trovafloxacin in patients with AIDS. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:12 Trovafloxacin pharmacokinetics were evaluated in 12 subjects with AIDS. By using a randomized design, single 200-mg doses of oral trovafloxacin and intravenous alatrofloxacin were administered. The mean absolute bioavailability was 91%. The pharmacokinetics of trovafloxacin when administered orally as the active form or intravenously as the prodrug (alatrofloxacin) are not altered in subjects with AIDS compared to those in healthy adults. Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Anti-Infective Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Fluoroquinolones; Half-Life; Humans; Injections, Intravenous; Naphthyridines; Prodrugs; Sample Size	1999

Article

Year

Oral bioavailability and pharmacokinetics of trovafloxacin in patients with AIDS.

Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:12

Trovafloxacin pharmacokinetics were evaluated in 12 subjects with AIDS. By using a randomized design, single 200-mg doses of oral trovafloxacin and intravenous alatrofloxacin were administered. The mean absolute bioavailability was 91%. The pharmacokinetics of trovafloxacin when administered orally as the active form or intravenously as the prodrug (alatrofloxacin) are not altered in subjects with AIDS compared to those in healthy adults.

Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Anti-Infective Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Fluoroquinolones; Half-Life; Humans; Injections, Intravenous; Naphthyridines; Prodrugs; Sample Size

1999