alaproclate has been researched along with Alzheimer Disease in 3 studies
alaproclate: specific 5-hydroxytryptamine uptake inhibitors; RN given refers to (DL)-isomer
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alaproclate, a specific inhibitor of neuronal serotonin re-uptake, was given to 12 patients with dementia of Alzheimer type." | 7.66 | Alaproclate: a pharmacokinetic and biochemical study in patients with dementia of Alzheimer type. ( Bergman, I; Bråne, G; Gottfries, CG; Jostell, KG; Karlsson, I; Svennerholm, L, 1983) |
| "Alaproclate, a specific inhibitor of neuronal serotonin re-uptake, was given to 12 patients with dementia of Alzheimer type." | 3.66 | Alaproclate: a pharmacokinetic and biochemical study in patients with dementia of Alzheimer type. ( Bergman, I; Bråne, G; Gottfries, CG; Jostell, KG; Karlsson, I; Svennerholm, L, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, L | 1 |
| Kumar, R | 1 |
| Pavlov, PF | 1 |
| Winblad, B | 1 |
| Bergman, I | 1 |
| Bråne, G | 1 |
| Gottfries, CG | 1 |
| Jostell, KG | 1 |
| Karlsson, I | 1 |
| Svennerholm, L | 1 |
| Hollander, E | 1 |
| Mohs, RC | 1 |
| Davis, KL | 1 |
2 reviews available for alaproclate and Alzheimer Disease
| Article | Year |
|---|---|
Small molecule therapeutics for tauopathy in Alzheimer's disease: Walking on the path of most resistance.
Topics: Alzheimer Disease; Animals; Benzodioxoles; Cholinesterase Inhibitors; Cholinesterases; Curcumin; Hum | 2021 |
Cholinergic approaches to the treatment of Alzheimer's disease.
Topics: 4-Aminopyridine; Alanine; Alzheimer Disease; Aminopyridines; Arecoline; Clinical Trials as Topic; Hu | 1986 |
1 trial available for alaproclate and Alzheimer Disease
| Article | Year |
|---|---|
Cholinergic approaches to the treatment of Alzheimer's disease.
Topics: 4-Aminopyridine; Alanine; Alzheimer Disease; Aminopyridines; Arecoline; Clinical Trials as Topic; Hu | 1986 |
1 other study available for alaproclate and Alzheimer Disease
| Article | Year |
|---|---|
Alaproclate: a pharmacokinetic and biochemical study in patients with dementia of Alzheimer type.
Topics: Aged; Alanine; Alzheimer Disease; Dementia; Female; Humans; Kinetics; Male; Serotonin | 1983 |