alanine has been researched along with Uremia in 25 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In hepatocytes isolated from uremic and control rats, we investigated: (1) the influence of uremia on gluconeogenesis and ureagenesis during incubations with alanine; (2) the kinetics of alanine plasma-membrane transport; (3) the relationships between intracellular alanine concentrations and its metabolism." | 7.72 | Effect of chronic renal failure with metabolic acidosis on alanine metabolism in isolated liver cells. ( Cano, N; El-Mir, MY; Leverve, XM; Meijer, AJ; Novaretti, R; Reynier, JP; Sturm, JM, 2004) |
| "The mechanism of the increased alanine and glutamine formation and release from skeletal muscle in experimental uremia was investigated using epitrochlearis preparations from control and chronically uremic rats." | 7.66 | The regulation of skeletal muscle alanine and glutamine formation and release in experimental chronic uremia in the rat: subsensitivity of adenylate cyclase and amino acid release to epinephrine and serotonin. ( Garber, AJ, 1978) |
| "To evaluate the mechanism and role of hyperglucagonemia in the carbohydrate intolerance of uremia, 19 patients with chronic renal failure (12 of whom had undergone chronic hemodialysis for at least 11 mo) and 35 healthy control subjects were studied." | 7.65 | Influence of uremia and hemodialysis on the turnover and metabolic effects of glucagon. ( Bastl, C; Black, H; Felig, P; Finkelstein, FO; Fisher, M; Hendler, R; Sherwin, RS, 1976) |
| "In hepatocytes isolated from uremic and control rats, we investigated: (1) the influence of uremia on gluconeogenesis and ureagenesis during incubations with alanine; (2) the kinetics of alanine plasma-membrane transport; (3) the relationships between intracellular alanine concentrations and its metabolism." | 3.72 | Effect of chronic renal failure with metabolic acidosis on alanine metabolism in isolated liver cells. ( Cano, N; El-Mir, MY; Leverve, XM; Meijer, AJ; Novaretti, R; Reynier, JP; Sturm, JM, 2004) |
| "The mechanism of the increased alanine and glutamine formation and release from skeletal muscle in experimental uremia was investigated using epitrochlearis preparations from control and chronically uremic rats." | 3.66 | The regulation of skeletal muscle alanine and glutamine formation and release in experimental chronic uremia in the rat: subsensitivity of adenylate cyclase and amino acid release to epinephrine and serotonin. ( Garber, AJ, 1978) |
| "During a 72-hr period of starvation plasma levels of glucose and immunoreactive insulin fell to a greater extent, and alanine, free fatty acid, and glycerol concentrations were higher in fasted chronically uremic rats than in nonuremic controls." | 3.65 | Evidence for an accelerated adaptation to starvation in chronic uremia. ( Bagdade, JD; Shafrir, E; Yee, E, 1977) |
| "To evaluate the mechanism and role of hyperglucagonemia in the carbohydrate intolerance of uremia, 19 patients with chronic renal failure (12 of whom had undergone chronic hemodialysis for at least 11 mo) and 35 healthy control subjects were studied." | 3.65 | Influence of uremia and hemodialysis on the turnover and metabolic effects of glucagon. ( Bastl, C; Black, H; Felig, P; Finkelstein, FO; Fisher, M; Hendler, R; Sherwin, RS, 1976) |
| "Uremia is associated with a high cardiovascular mortality, the causes of which are still not completely explained, but are related to uremic toxicity, due to the accumulation of retention products." | 2.55 | The Sulfur Metabolite Lanthionine: Evidence for a Role as a Novel Uremic Toxin. ( Ingrosso, D; Perna, AF; Trepiccione, F; Zacchia, M, 2017) |
| " The dose-response curve for cAMP formation stimulated by epinephrine was shifted 1 log unit to the right in uremic muscle and adenylyl cyclase stimulation by epinephrine was shifted 1 log unit." | 1.26 | Skeletal muscle amino acid metabolism in chronic uremia. ( Garber, AJ; Maillet, C, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (68.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perna, AF | 4 |
| Anishchenko, E | 2 |
| Vigorito, C | 3 |
| Zacchia, M | 4 |
| Trepiccione, F | 4 |
| D'Aniello, S | 1 |
| Ingrosso, D | 4 |
| Mele, L | 1 |
| Capolongo, G | 1 |
| Lombari, P | 1 |
| Capasso, R | 1 |
| Shimomura, A | 1 |
| Matsui, I | 1 |
| Hamano, T | 1 |
| Ishimoto, T | 1 |
| Katou, Y | 1 |
| Takehana, K | 1 |
| Inoue, K | 1 |
| Kusunoki, Y | 1 |
| Mori, D | 1 |
| Nakano, C | 1 |
| Obi, Y | 1 |
| Fujii, N | 1 |
| Takabatake, Y | 1 |
| Nakano, T | 1 |
| Tsubakihara, Y | 1 |
| Isaka, Y | 1 |
| Rakugi, H | 1 |
| Di Nunzio, A | 1 |
| Amoresano, A | 1 |
| Pane, F | 1 |
| Fontanarosa, C | 1 |
| Pucci, P | 1 |
| Cirillo, G | 1 |
| Cano, N | 1 |
| Sturm, JM | 1 |
| Meijer, AJ | 1 |
| El-Mir, MY | 1 |
| Novaretti, R | 1 |
| Reynier, JP | 1 |
| Leverve, XM | 1 |
| Delmez, JA | 1 |
| Rutherford, WE | 1 |
| Klahr, S | 2 |
| Blondin, J | 1 |
| Maillet, C | 1 |
| Garber, AJ | 4 |
| Harter, HR | 1 |
| Birge, SJ | 1 |
| Martin, KJ | 1 |
| Karl, IE | 1 |
| Clark, AS | 1 |
| Mitch, WE | 1 |
| Al Banchaabouchi, M | 1 |
| Marescau, B | 1 |
| D'Hooge, R | 1 |
| Engelborghs, S | 1 |
| De Deyn, PP | 1 |
| Nohara, Y | 1 |
| Suzuki, J | 1 |
| Kinoshita, T | 1 |
| Watanabe, M | 1 |
| Hansen, AP | 1 |
| Hansen, HE | 1 |
| Orskov, H | 1 |
| Nosadini, R | 1 |
| Noy, G | 1 |
| Alberti, KG | 2 |
| Jontofsohn, R | 1 |
| Trivisas, G | 1 |
| Katz, N | 1 |
| Kluthe, R | 1 |
| Holliday, MA | 1 |
| Chantler, C | 1 |
| MacDonnell, R | 1 |
| Keitges, J | 1 |
| Bagdade, JD | 1 |
| Yee, E | 1 |
| Shafrir, E | 1 |
| Sherwin, RS | 1 |
| Bastl, C | 1 |
| Finkelstein, FO | 1 |
| Fisher, M | 1 |
| Black, H | 1 |
| Hendler, R | 1 |
| Felig, P | 1 |
| Klim, RA | 1 |
| Albajar, M | 1 |
| Hems, R | 1 |
| Williamson, DH | 1 |
| Wolfson, M | 1 |
| Kopple, JD | 2 |
| Heaton, A | 1 |
| Johnston, DG | 1 |
| Haigh, JW | 1 |
| Ward, MK | 1 |
| Kerr, DN | 1 |
| Swendseid, ME | 1 |
| Shinaberger, JH | 1 |
| Umezawa, CY | 1 |
| Czerniak, Z | 1 |
| Burzyński, S | 1 |
1 review available for alanine and Uremia
| Article | Year |
|---|---|
The Sulfur Metabolite Lanthionine: Evidence for a Role as a Novel Uremic Toxin.
Topics: Alanine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Homocysteine; Humans; Hydrogen Sulf | 2017 |
1 trial available for alanine and Uremia
| Article | Year |
|---|---|
Divergent behavior of hydrogen sulfide pools and of the sulfur metabolite lanthionine, a novel uremic toxin, in dialysis patients.
Topics: Adult; Aged; Alanine; Female; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Male; Middle Aged; Ren | 2016 |
23 other studies available for alanine and Uremia
| Article | Year |
|---|---|
Zebrafish, a Novel Model System to Study Uremic Toxins: The Case for the Sulfur Amino Acid Lanthionine.
Topics: Alanine; Animals; Disease Models, Animal; Organogenesis; Sulfides; Toxins, Biological; Uremia; Xenob | 2018 |
Uremic Toxin Lanthionine Interferes with the Transsulfuration Pathway, Angiogenetic Signaling and Increases Intracellular Calcium.
Topics: Alanine; Amino Acids, Sulfur; Calcium; Cell Line; Cystathionine beta-Synthase; Endothelial Cells; Fl | 2019 |
Dietary L-lysine prevents arterial calcification in adenine-induced uremic rats.
Topics: Adenine; Alanine; Animals; Apoptosis; Arginine; Calcium; Calcium Phosphates; Cells, Cultured; Chemic | 2014 |
Effect of chronic renal failure with metabolic acidosis on alanine metabolism in isolated liver cells.
Topics: Acidosis; Alanine; Animals; Cells, Cultured; Gluconeogenesis; Hepatocytes; Kidney Failure, Chronic; | 2004 |
Studies on the role of the liver and splanchnic tissues in the production of carbohydrate intolerance in uremia.
Topics: Alanine; Animals; Gluconeogenesis; Glucose; Glutamates; Glutamic Acid; Glutamine; Humans; Kinetics; | 1981 |
Skeletal muscle amino acid metabolism in chronic uremia.
Topics: Adult; Alanine; Amino Acids; Animals; Bucladesine; Chronic Disease; Epinephrine; Fluorides; Glutamin | 1980 |
Effects of parathyroid hormone on skeletal muscle protein and amino acid metabolism in the rat.
Topics: Adenylyl Cyclases; Alanine; Amino Acids; Animals; Cyclic AMP; Epinephrine; Female; Glutamine; Hormon | 1983 |
Effects of vitamin D metabolites on protein catabolism of muscle from uremic rats.
Topics: Alanine; Animals; Calcifediol; Calcitriol; Insulin; Male; Muscle Proteins; Muscles; Phenylalanine; R | 1983 |
Muscle protein turnover and glucose uptake in acutely uremic rats. Effects of insulin and the duration of renal insufficiency.
Topics: Acute Disease; Alanine; Animals; Body Weight; Glucose; Insulin; Lactates; Male; Muscle Proteins; Rat | 1983 |
Consequences of renal mass reduction on amino acid and biogenic amine levels in nephrectomized mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alanine; Amino Acids; Animals; Biogenic Amines; Brain; Citrulline; D | 2000 |
Creatinine inhibits D-amino acid oxidase.
Topics: Alanine; Alanine Transaminase; Creatinine; D-Amino-Acid Oxidase; Enzyme Activation; Flavin-Adenine D | 2002 |
The regulation of skeletal muscle alanine and glutamine formation and release in experimental chronic uremia in the rat: subsensitivity of adenylate cyclase and amino acid release to epinephrine and serotonin.
Topics: Adenylyl Cyclases; Alanine; Amino Acids; Animals; Chronic Disease; Cyclic AMP; Epinephrine; Glutamin | 1978 |
Normalisation of growth hormone hypersecretion in uraemic diabetics and non-diabetics. Studies with artificial pancreas and artificial kidney.
Topics: Alanine; Artificial Organs; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Fe | 1979 |
Skeletal muscle protein and amino acid metabolism in experimental chronic uremia in the rat: accelerated alanine and glutamine formation and release.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acids; Animals; Carbohydrate Metabolis | 1978 |
Amino acid content of erythrocytes in uremia.
Topics: Alanine; Amino Acids; Erythrocytes; Histidine; Humans; Renal Dialysis; Serine; Tyrosine; Uremia | 1978 |
Effect of uremia on nutritionally-induced variations in protein metabolism.
Topics: Alanine; Amino Acids; Animals; Blood Proteins; Eating; Extracellular Space; Fasting; Insulin; Intrac | 1977 |
Evidence for an accelerated adaptation to starvation in chronic uremia.
Topics: Adaptation, Physiological; Alanine; Animals; Blood Glucose; Fatty Acids, Nonesterified; Insulin; Mal | 1977 |
Influence of uremia and hemodialysis on the turnover and metabolic effects of glucagon.
Topics: Adolescent; Adult; Alanine; Amino Acids; Blood Glucose; Female; Glucagon; Glucose; Humans; Insulin; | 1976 |
Effects of chronic uraemia on the formation of glucose and urea plus ammonia from L-alanine, L-glutamine and L-serine in isolated rat hepatocytes.
Topics: Acidosis; Alanine; Amino Acids; Ammonia; Animals; Gluconeogenesis; Glutaminase; Glutamine; In Vitro | 1986 |
The effects of vitamin B-6 deficiency in chronically azotemic and sham-operated rats.
Topics: Alanine; Animals; Asparagine; Aspartate Aminotransferases; Chronic Disease; Creatinine; Erythrocytes | 1987 |
Twenty-four hour hormonal and metabolic profiles in uraemic patients before and during treatment with continuous ambulatory peritoneal dialysis.
Topics: Adult; Alanine; Blood Glucose; Creatinine; Fasting; Fatty Acids, Nonesterified; Female; Humans; Keto | 1985 |
The free and bound amino acids removed by hemodialysis.
Topics: Adult; Alanine; Amino Acids; Asparagine; Aspartic Acid; Blood Flow Velocity; Blood Glucose; Body Wei | 1973 |
Free amino acids in serum of patients with chronic renal insufficiency.
Topics: Adult; Aged; Alanine; Amino Acids; Analysis of Variance; Arginine; Chromatography, Paper; Cystine; F | 1969 |