alanine has been researched along with Stomach Ulcer in 70 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " pylori-positive gastric ulcer patients were assigned at random to two groups; in addition to dual therapy (amoxicillin 500 mg thrice daily and lansoprazole 30 mg every morning for two weeks), one group received rebamipide 100 mg thrice daily for eight weeks, while the other group received teprenone 50 mg thrice daily for eight weeks." | 9.08 | Effects of rebamipide in combination with lansoprazole and amoxicillin on Helicobacter pylori-infected gastric ulcer patients. ( Asaka, M; Hokari, K; Kagaya, H; Katagiri, M; Kato, M; Kudo, M; Nishikawa, K; Sato, F; Sugiyama, T; Sukegawa, M; Takeda, H, 1998) |
| " Since prostaglandins are inducers of hepatocyte growth factor (HGF), we examined the effect of rebamipide on the expression of HGF, c-met, cyclooxygenase-2 (Cox-2) and subtype of the prostaglandin E2 receptor (EP2) in acetic acid-induced gastric ulcer, a model of human ulcer." | 7.72 | Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor. ( Ichiba, M; Murawaki, Y; Shiota, G; Udagawa, A, 2003) |
| "This study was done to elucidate whether rebamipide during the initial period of acetic acid-induced gastric ulcer affected healing and future ulcer relapse." | 7.69 | Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine. ( Arakawa, T; Fukuda, T; Kobayashi, K; Watanabe, T; Yamasaki, K, 1995) |
| "In this prospective, randomized, multicenter, open-label, and comparative study, patients who had undergone ESD for EGC or gastric adenoma were randomized into groups receiving either rabeprazole monotherapy (10 mg/day, n=64) or a combination of rabeprazole plus rebamipide (300 mg/day, n=66)." | 5.22 | Limited Effect of Rebamipide in Addition to Proton Pump Inhibitor (PPI) in the Treatment of Post-Endoscopic Submucosal Dissection Gastric Ulcers: A Randomized Controlled Trial Comparing PPI Plus Rebamipide Combination Therapy with PPI Monotherapy. ( Akahoshi, K; Akiho, H; Aso, A; Harada, N; Iboshi, Y; Ihara, E; Iwasa, T; Nakamura, K; Nakamura, N; Ochiai, T; Ogino, H; Takayanagi, R, 2016) |
| " pylori-positive gastric ulcer patients were assigned at random to two groups; in addition to dual therapy (amoxicillin 500 mg thrice daily and lansoprazole 30 mg every morning for two weeks), one group received rebamipide 100 mg thrice daily for eight weeks, while the other group received teprenone 50 mg thrice daily for eight weeks." | 5.08 | Effects of rebamipide in combination with lansoprazole and amoxicillin on Helicobacter pylori-infected gastric ulcer patients. ( Asaka, M; Hokari, K; Kagaya, H; Katagiri, M; Kato, M; Kudo, M; Nishikawa, K; Sato, F; Sugiyama, T; Sukegawa, M; Takeda, H, 1998) |
| " Six scoparone derivatives were synthesized and screened for gastroprotective activities against HCl/ethanol- and indomethacin-induced gastric ulcers in rats." | 3.81 | Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents. ( Choi, WS; Lee, GR; Lee, SE; Oh, S; Son, DJ, 2015) |
| "Polaprezinc (PZ), which consists of l-carnosine and zinc, is widely used to treat gastric ulcers." | 3.79 | The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: comparison study with rebamipide. ( Choi, HS; Chun, HJ; Jeen, YT; Keum, B; Kim, CD; Kim, ES; Lee, HS; Lee, M; Lim, JY; Ryu, HS; Seo, YS; Sul, D; Um, SH, 2013) |
| " once daily for 1 week, markedly delayed the healing of acetic acid-induced gastric ulcers with the suppression of basic fibroblast growth factor (bFGF) expression." | 3.74 | Prophylactic effect of rebamipide against the irritative and healing impairment actions of alendronate in rat stomachs. ( Aihara, E; Amagase, K; Hayashi, S; Kato, S; Takeuchi, K, 2007) |
| " Since prostaglandins are inducers of hepatocyte growth factor (HGF), we examined the effect of rebamipide on the expression of HGF, c-met, cyclooxygenase-2 (Cox-2) and subtype of the prostaglandin E2 receptor (EP2) in acetic acid-induced gastric ulcer, a model of human ulcer." | 3.72 | Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor. ( Ichiba, M; Murawaki, Y; Shiota, G; Udagawa, A, 2003) |
| "This study was done to elucidate whether rebamipide during the initial period of acetic acid-induced gastric ulcer affected healing and future ulcer relapse." | 3.69 | Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine. ( Arakawa, T; Fukuda, T; Kobayashi, K; Watanabe, T; Yamasaki, K, 1995) |
| " No serious adverse events were observed in any of the patients in either group." | 2.80 | Efficacy and safety of 1-week Helicobacter pylori eradication therapy and 7-week rebamipide treatment after endoscopic submucosal dissection of early gastric cancer in comparison with 8-week PPI standard treatment: a randomized, controlled, prospective, m ( Azuma, T; Higuchi, K; Iguchi, M; Machida, H; Morita, Y; Naito, Y; Takeuchi, T; Takeuchi, Y; Tamada, T; Tominaga, K; Uedo, N; Yagi, N; Yamao, J; Yazumi, S, 2015) |
| " When the possibility of poor compliance and the potential adverse effects of misoprostol are considered, rebamipide appears to be a clinically effective and safe alternative." | 2.79 | Preventive efficacy and safety of rebamipide in nonsteroidal anti-inflammatory drug-induced mucosal toxicity. ( Cho, CS; Kang, YM; Kim, JH; Kim, SK; Lee, DH; Lee, SK; Lee, ST; Lee, YC; Park, SH; Park, W; Park, YW; Rew, JS; Yoo, WH, 2014) |
| "Famotidine was superior to rebamipide in treating NSAID-associated mucosal lesions." | 2.72 | Assessing the efficacy of famotidine and rebamipide in the treatment of gastric mucosal lesions in patients receiving long-term NSAID therapy (FORCE--famotidine or rebamipide in comparison by endoscopy). ( Akiyama, K; Ann, T; Fukui, H; Haruma, K; Kikuchi, E; Kinoshita, Y; Kojima, H; Matsumoto, M; Mitoro, A; Miyauchi, Y; Nakayama, M; Ono, H; Sakurai, G; Takakura, Y; Yajima, H; Yamao, J; Yoshida, M; Yoshikawa, M, 2006) |
| "The ulcer recurrence rate was significantly lower in group OA and group OR than in group O." | 2.69 | Rebamipide prevents recurrence of gastric ulcers without affecting Helicobacter pylori status. ( Ando, K; Arakawa, T; Fujiwara, Y; Fukuda, T; Higuchi, K; Kobayashi, K; Kuroki, T; Nebiki, H; Takaishi, O; Uchida, T; Yamasaki, K, 1998) |
| " Sixty patients received 40 mg of omeprazole twice a day, 1500 mg of amoxicillin three times a day, and 300 mg of rebamipide three times a day (group OAR); the other 60 patients received the same dosage of omeprazole and amoxicillin but no rebamipide for two weeks (group OA)." | 2.69 | Effect of rebamipide on Helicobacter pylori infection in patients with peptic ulcer. ( Ando, K; Arakawa, T; Harihara, S; Higuchi, K; Ito, H; Kobayashi, K; Kuroki, T; Nebiki, H; Uchida, T, 1998) |
| " dosing at 10 mg/kg/hr by the hydrogen gas clearance method; (3) rebamipide at 10 mg/kg, i." | 2.67 | [Protective effect of rebamipide (OPC-12759) on the gastric mucosa in rats and humans]. ( Imaizumi, T; Kamada, T; Kawano, S; Komemushi, S; Sato, N; Yamasaki, K, 1991) |
| " No serious adverse events were observed in either group." | 2.50 | Efficacy and safety of proton pump inhibitors (PPIs) plus rebamipide for endoscopic submucosal dissection-induced ulcers: a meta-analysis. ( Cao, Z; Dong, W; Guo, X; Liu, M; Song, J; Wang, J; Ye, C; Yu, S; Zhang, J, 2014) |
| "Rebamipide (REB) a potent anti-ulcer agent, has not been exploited to its full potential, owing to it extremely poor solubility, leading to highly diminutive bioavailability (<10%)." | 1.62 | Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies. ( Chadha, R; Dureja, J; Jindal, A; Karan, M; Singh, R; Tomar, S, 2021) |
| "Mucosal inflammation is a crucial factor for the recurrence of peptic ulcer." | 1.33 | Rebamipide reduces recurrence of experimental gastric ulcers: role of free radicals and neutrophils. ( Osaka, T; Sakurai, K; Yamasaki, K, 2005) |
| " Given intraperitoneally at the single dosing range of 10-100 mg/kg, OPC-12759 inhibited the formation of these acute gastric ulcer models." | 1.28 | Effect of OPC-12759, a novel antiulcer agent, on chronic and acute experimental gastric ulcer, and gastric secretion in rats. ( Imaizumi, T; Ishiyama, H; Kanbe, T; Yabuuchi, Y; Yamasaki, K, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (8.57) | 18.7374 |
| 1990's | 21 (30.00) | 18.2507 |
| 2000's | 16 (22.86) | 29.6817 |
| 2010's | 23 (32.86) | 24.3611 |
| 2020's | 4 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Jindal, A | 1 |
| Singh, R | 1 |
| Tomar, S | 1 |
| Dureja, J | 1 |
| Karan, M | 1 |
| Chadha, R | 1 |
| Jung, DH | 1 |
| Park, JC | 1 |
| Lee, YC | 4 |
| Lee, SK | 3 |
| Shin, SK | 1 |
| Chung, H | 1 |
| Park, JJ | 2 |
| Kim, JH | 5 |
| Youn, YH | 1 |
| Park, H | 1 |
| Liu, J | 1 |
| Xiong, Z | 1 |
| Geng, X | 1 |
| Cui, M | 1 |
| Kim, GH | 1 |
| Lee, HL | 1 |
| Joo, MK | 1 |
| Park, HJ | 1 |
| Jung, SW | 1 |
| Lee, OJ | 1 |
| Kim, H | 1 |
| Chun, HJ | 2 |
| Lee, ST | 2 |
| Kim, JW | 1 |
| Jeon, HH | 1 |
| Chung, IK | 1 |
| Kim, HS | 1 |
| Lee, DH | 3 |
| Kim, KO | 2 |
| Lim, YJ | 1 |
| Park, SJ | 1 |
| Cho, SJ | 1 |
| Kim, BW | 1 |
| Ko, KH | 1 |
| Jeon, SW | 1 |
| Kim, JG | 1 |
| Sung, IK | 1 |
| Kim, TN | 1 |
| Sung, JK | 1 |
| Fujimoto, A | 1 |
| Uraoka, T | 1 |
| Nishizawa, T | 1 |
| Shimoda, M | 1 |
| Goto, O | 1 |
| Ochiai, Y | 1 |
| Maehata, T | 1 |
| Akimoto, T | 1 |
| Mitsunaga, Y | 1 |
| Sasaki, M | 1 |
| Yamamoto, H | 1 |
| Yahagi, N | 1 |
| Ichida, T | 1 |
| Ueyama, S | 1 |
| Eto, T | 1 |
| Kusano, F | 1 |
| Sakai, Y | 1 |
| Yan, B | 1 |
| Lu, Z | 1 |
| Ge, Z | 1 |
| Liu, S | 1 |
| Guo, X | 2 |
| Tian, D | 1 |
| Yang, Y | 4 |
| Li, X | 1 |
| Gong, W | 1 |
| Liu, Z | 1 |
| Liu, M | 2 |
| Zhou, B | 1 |
| Zhao, K | 1 |
| Pan, F | 1 |
| Yang, J | 2 |
| Choi, HS | 1 |
| Lim, JY | 1 |
| Lee, M | 1 |
| Kim, ES | 1 |
| Keum, B | 1 |
| Seo, YS | 1 |
| Jeen, YT | 1 |
| Um, SH | 1 |
| Lee, HS | 2 |
| Kim, CD | 2 |
| Ryu, HS | 1 |
| Sul, D | 1 |
| Wang, J | 2 |
| Ye, C | 1 |
| Yu, S | 1 |
| Zhang, J | 1 |
| Song, J | 1 |
| Cao, Z | 1 |
| Dong, W | 1 |
| Park, SH | 1 |
| Cho, CS | 1 |
| Yoo, WH | 1 |
| Kim, SK | 1 |
| Kang, YM | 1 |
| Rew, JS | 1 |
| Park, YW | 1 |
| Park, W | 1 |
| Higuchi, K | 8 |
| Takeuchi, T | 1 |
| Uedo, N | 1 |
| Takeuchi, Y | 2 |
| Naito, Y | 4 |
| Yagi, N | 2 |
| Tominaga, K | 5 |
| Machida, H | 1 |
| Tamada, T | 1 |
| Morita, Y | 2 |
| Yazumi, S | 1 |
| Yamao, J | 2 |
| Iguchi, M | 1 |
| Azuma, T | 2 |
| Xiong, J | 1 |
| Lai, S | 1 |
| Zhang, P | 1 |
| Li, Q | 1 |
| Wei, Y | 1 |
| Wang, T | 1 |
| Liu, L | 1 |
| Ma, X | 1 |
| Chen, D | 1 |
| Choi, YJ | 2 |
| Kim, N | 1 |
| Lee, JY | 1 |
| Nam, RH | 1 |
| Chang, H | 1 |
| Seo, JH | 1 |
| Kang, KK | 1 |
| Kim, HJ | 1 |
| Takeuchi, K | 4 |
| Takayama, S | 1 |
| Hashimoto, E | 1 |
| Itayama, M | 1 |
| Amagase, K | 3 |
| Izuhara, C | 1 |
| Son, DJ | 1 |
| Lee, GR | 1 |
| Oh, S | 1 |
| Lee, SE | 1 |
| Choi, WS | 1 |
| Abe, N | 1 |
| Funato, H | 1 |
| Hirata, A | 1 |
| Nakai, M | 1 |
| Iizuka, M | 1 |
| Shiraishi, H | 1 |
| Jobu, K | 1 |
| Yagi, Y | 1 |
| Kadota, A | 1 |
| Ogi, K | 1 |
| Yokota, J | 1 |
| Miyamura, M | 1 |
| Nakamura, K | 1 |
| Ihara, E | 1 |
| Akiho, H | 1 |
| Akahoshi, K | 1 |
| Harada, N | 2 |
| Ochiai, T | 1 |
| Nakamura, N | 1 |
| Ogino, H | 1 |
| Iwasa, T | 1 |
| Aso, A | 1 |
| Iboshi, Y | 1 |
| Takayanagi, R | 1 |
| Goineau, S | 1 |
| Castagné, V | 1 |
| Lee, S | 1 |
| Jeong, S | 1 |
| Kim, W | 1 |
| Kim, D | 1 |
| Yoon, JH | 1 |
| Kim, BJ | 1 |
| Min, DS | 1 |
| Jung, Y | 1 |
| Thong-Ngam, D | 1 |
| Chayanupatkul, M | 1 |
| Klaikeaw, N | 1 |
| Rerknimitr, R | 1 |
| Mahachai, V | 1 |
| Ohashi, Y | 1 |
| Aihara, E | 2 |
| Takasuka, H | 1 |
| Takahashi, K | 1 |
| Kato, T | 1 |
| Araki, H | 1 |
| Onogi, F | 1 |
| Ibuka, T | 1 |
| Sugiyama, A | 1 |
| Tomita, E | 1 |
| Nagaki, M | 1 |
| Moriwaki, H | 1 |
| Kim, YJ | 1 |
| Cheon, JH | 1 |
| Yoshikawa, T | 7 |
| Fujiwara, S | 1 |
| Toyonaga, T | 1 |
| Kawakami, F | 1 |
| Itoh, T | 1 |
| Yoshida, M | 3 |
| Kutsumi, H | 1 |
| Kato, S | 2 |
| Song, KH | 1 |
| Fan, DM | 1 |
| Ge, ZZ | 1 |
| Ji, F | 1 |
| Chen, MH | 1 |
| Jung, HC | 1 |
| Bo, J | 1 |
| Lee, SW | 1 |
| Kobayashi, M | 1 |
| Takeuchi, M | 1 |
| Hashimoto, S | 1 |
| Mizuno, K | 1 |
| Sato, Y | 1 |
| Narisawa, R | 1 |
| Aoyagi, Y | 1 |
| Shin, WG | 1 |
| Kim, SJ | 1 |
| Choi, MH | 1 |
| Jang, HJ | 1 |
| Park, CH | 1 |
| Baek, IH | 1 |
| Kim, KH | 1 |
| Baik, GH | 1 |
| Kae, SH | 1 |
| Kim, HY | 1 |
| Watanabe, T | 5 |
| Hamaguchi, M | 1 |
| Tanigawa, T | 1 |
| Wada, R | 1 |
| Fujiwara, Y | 5 |
| Arakawa, T | 12 |
| Udagawa, A | 1 |
| Shiota, G | 1 |
| Ichiba, M | 1 |
| Murawaki, Y | 1 |
| Nakamura, M | 1 |
| Akiba, Y | 1 |
| Matsui, H | 1 |
| Tsuchimoto, K | 1 |
| Ishii, H | 4 |
| Fujioka, T | 2 |
| Shimoyama, T | 1 |
| Itoh, M | 1 |
| Asaka, M | 4 |
| Kuwayama, H | 1 |
| Sato, R | 1 |
| Kawai, S | 1 |
| Takemoto, T | 2 |
| Kobayashi, K | 9 |
| PIPER, DW | 1 |
| MACOUN, ML | 1 |
| BUILDER, JE | 1 |
| FENTON, BH | 1 |
| Taira, K | 1 |
| Sasaki, E | 2 |
| Shiba, M | 1 |
| Oshitani, N | 1 |
| Sakurai, K | 1 |
| Osaka, T | 1 |
| Yamasaki, K | 9 |
| Terano, A | 2 |
| Sugiyama, T | 4 |
| Haruma, K | 3 |
| Shimosegawa, T | 1 |
| Sakaki, N | 1 |
| Sakamoto, C | 1 |
| Takahashi, S | 2 |
| Kinoshita, Y | 2 |
| Kikuchi, E | 1 |
| Matsumoto, M | 1 |
| Nakayama, M | 1 |
| Ann, T | 1 |
| Kojima, H | 1 |
| Mitoro, A | 1 |
| Yoshikawa, M | 1 |
| Yajima, H | 1 |
| Miyauchi, Y | 1 |
| Ono, H | 2 |
| Akiyama, K | 1 |
| Sakurai, G | 1 |
| Takakura, Y | 1 |
| Fukui, H | 1 |
| Suzuki, H | 2 |
| Joh, T | 1 |
| Murakami, K | 2 |
| Hayashi, S | 2 |
| Takahashi, M | 1 |
| Fuchikami, J | 1 |
| Abasov, IT | 1 |
| Hong, KW | 1 |
| Fukuda, T | 3 |
| Kitahora, T | 1 |
| Wakabayashi, G | 1 |
| Tashiro, H | 1 |
| Otani, Y | 1 |
| Shimazu, M | 1 |
| Kubota, T | 1 |
| Kumai, K | 1 |
| Kitajima, M | 1 |
| Nakamura, S | 1 |
| Nishimura, S | 1 |
| Kaneko, T | 1 |
| Iinuma, S | 2 |
| Kondo, M | 2 |
| Huh, K | 1 |
| Shin, US | 1 |
| Lee, SH | 1 |
| Son, M | 1 |
| Kim, HK | 1 |
| Kim, WB | 1 |
| Kim, BK | 1 |
| Tarnawski, A | 2 |
| Takaishi, O | 2 |
| Uchida, T | 3 |
| Kuroki, T | 3 |
| Matsuyama, K | 1 |
| Boku, Y | 1 |
| Fujii, T | 1 |
| Yoshida, N | 1 |
| Nebiki, H | 2 |
| Ando, K | 2 |
| Okajima, K | 1 |
| Isobe, H | 1 |
| Okabe, H | 1 |
| Mori, M | 1 |
| Kai, A | 1 |
| Suzuki, M | 1 |
| Suematsu, M | 1 |
| Miura, S | 1 |
| Kato, M | 1 |
| Kudo, M | 1 |
| Nishikawa, K | 1 |
| Sukegawa, M | 1 |
| Hokari, K | 1 |
| Katagiri, M | 1 |
| Sato, F | 1 |
| Kagaya, H | 1 |
| Takeda, H | 1 |
| Ito, H | 1 |
| Harihara, S | 1 |
| Song, DU | 1 |
| Ryu, MH | 1 |
| Chay, KO | 1 |
| Jung, YD | 1 |
| Yang, SY | 1 |
| Cha, SH | 1 |
| Lee, MW | 1 |
| Ahn, BW | 1 |
| Nomura, H | 1 |
| Miyake, K | 1 |
| Hirakata, R | 1 |
| Migita, S | 1 |
| Okamoto, O | 1 |
| Shiraishi, G | 1 |
| Hirasaki, S | 1 |
| Koide, N | 1 |
| Ogawa, H | 1 |
| Tsuji, T | 1 |
| Yokota, K | 1 |
| Isogai, H | 1 |
| Isogai, E | 1 |
| Shimomura, H | 1 |
| Oguma, K | 1 |
| Hirai, Y | 1 |
| Sun, WH | 1 |
| Tsuji, S | 1 |
| Tsujii, M | 1 |
| Gunawan, ES | 1 |
| Kawai, N | 1 |
| Kimura, A | 1 |
| Kakiuchi, Y | 1 |
| Yasumaru, M | 1 |
| Iijima, H | 1 |
| Okuda, Y | 1 |
| Sasaki, Y | 1 |
| Hori, M | 1 |
| Kawano, S | 2 |
| Ogino, K | 2 |
| Hobara, T | 2 |
| Ishiyama, H | 3 |
| Kobayashi, H | 1 |
| Izumi, Y | 1 |
| Oka, S | 2 |
| Sato, N | 1 |
| Kamada, T | 1 |
| Imaizumi, T | 2 |
| Komemushi, S | 1 |
| Yoshimura, S | 1 |
| Okazaki, Y | 1 |
| Iida, Y | 1 |
| Kanbe, T | 3 |
| Yabuuchi, Y | 2 |
| Shiraki, M | 1 |
| Asada, S | 1 |
| Hirata, I | 1 |
| Ooshiba, S | 1 |
| Uchida, M | 1 |
| Tabusa, F | 1 |
| Komatsu, M | 1 |
| Morita, S | 1 |
| Nakagawa, K | 1 |
| Dolif, D | 1 |
| Jürgens, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Is Rebamipide Effective on the Healing of Iatrogenic Gastric Ulcer After Endoscopic Mucosal Resection? : Multicenter, Randomized, and Prospective Study[NCT01167101] | 290 participants (Actual) | Interventional | 2009-05-31 | Completed | |||
| Rebamipide Ophthalmic Suspension in the Treatment of Dry Eye: A Multicenter, Phase 3, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group, 52 Week Study[NCT00201981] | Phase 3 | 740 participants (Anticipated) | Interventional | 2004-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for alanine and Stomach Ulcer
| Article | Year |
|---|---|
Rebamipide with Proton Pump Inhibitors (PPIs) versus PPIs Alone for the Treatment of Endoscopic Submucosal Dissection-Induced Ulcers: A Meta-analysis.
Topics: Alanine; Anti-Ulcer Agents; Endoscopic Mucosal Resection; Female; Humans; Male; Middle Aged; Proton | 2020 |
Efficacy and safety of proton pump inhibitors (PPIs) plus rebamipide for endoscopic submucosal dissection-induced ulcers: a meta-analysis.
Topics: Alanine; Anti-Ulcer Agents; Dissection; Drug Therapy, Combination; Endoscopy; Humans; Proton Pump In | 2014 |
Rebamipide plus proton pump inhibitor versus proton pump inhibitor alone in the treatment of endoscopic submucosal dissection-induced gastric ulcer: a meta-analysis of randomized controlled trials.
Topics: Adenoma; Aged; Aged, 80 and over; Alanine; Anti-Ulcer Agents; Drug Therapy, Combination; Endoscopy, | 2014 |
Gastric ulcerogenic and healing impairment actions of alendronate, a nitrogen-containing bisphosphonate - prophylactic effects of rebamipide.
Topics: Alanine; Alendronate; Animals; Anti-Ulcer Agents; Bone Density Conservation Agents; Humans; Quinolon | 2011 |
[Quality of ulcer healing and rebamipide].
Topics: Alanine; Amoxicillin; Animals; Anti-Ulcer Agents; Antioxidants; Cytokines; Drug Therapy, Combination | 2005 |
Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing.
Topics: Alanine; Animals; Anti-Ulcer Agents; Clinical Trials as Topic; Disease Models, Animal; Gastric Mucos | 1998 |
Benign gastric ulcer associated with Canidida infection in a healthy adult.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Alanine; Anti-Infective Agents; Anti-Ulcer Agents; Candidia | 1999 |
24 trials available for alanine and Stomach Ulcer
| Article | Year |
|---|---|
Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers.
Topics: Alanine; Anti-Ulcer Agents; Carnosine; Drug Therapy, Combination; Endoscopic Mucosal Resection; Huma | 2021 |
Efficacy and Safety of Rebamipide versus Its New Formulation, AD-203, in Patients with Erosive Gastritis: A Randomized, Double-Blind, Active Control, Noninferiority, Multicenter, Phase 3 Study.
Topics: Alanine; Double-Blind Method; Gastritis; Humans; Quinolones; Stomach Ulcer; Treatment Outcome | 2021 |
Randomized Controlled Trial Comparing the Effects of Vonoprazan Plus Rebamipide and Esomeprazole Plus Rebamipide on Gastric Ulcer Healing Induced by Endoscopic Submucosal Dissection.
Topics: Aged; Aged, 80 and over; Alanine; Anti-Ulcer Agents; Drug Therapy, Combination; Endoscopic Mucosal R | 2019 |
A Multicenter, Randomized, Controlled Trial of Rebamipide Plus Lansoprazole for the Treatment of Postendoscopic Submucosal Dissection Ulcers.
Topics: Administration, Oral; Aged; Alanine; Anti-Ulcer Agents; Biopsy; Double-Blind Method; Drug Therapy, C | 2019 |
Preventive efficacy and safety of rebamipide in nonsteroidal anti-inflammatory drug-induced mucosal toxicity.
Topics: Adult; Aged; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Butanon | 2014 |
Efficacy and safety of 1-week Helicobacter pylori eradication therapy and 7-week rebamipide treatment after endoscopic submucosal dissection of early gastric cancer in comparison with 8-week PPI standard treatment: a randomized, controlled, prospective, m
Topics: Aged; Alanine; Anti-Bacterial Agents; Clarithromycin; Dissection; Early Detection of Cancer; Female; | 2015 |
Limited Effect of Rebamipide in Addition to Proton Pump Inhibitor (PPI) in the Treatment of Post-Endoscopic Submucosal Dissection Gastric Ulcers: A Randomized Controlled Trial Comparing PPI Plus Rebamipide Combination Therapy with PPI Monotherapy.
Topics: Adenoma; Aged; Alanine; Anti-Ulcer Agents; Drug Therapy, Combination; Endoscopic Mucosal Resection; | 2016 |
Effect of rebamipide on gastric ulcer healing caused by Helicobacter pylori and/or NSAIDs or non NSAIDs-non H. pylori.
Topics: Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Female; Follow-Up Studies; Heli | 2009 |
Clinical trial: rebamipide promotes gastric ulcer healing by proton pump inhibitor after endoscopic submucosal dissection--a randomized controlled study.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alanine; Anti-Ulcer Agents; Drug Synergism; Drug Ther | 2010 |
Rebamipide may be comparable to H2 receptor antagonist in healing iatrogenic gastric ulcers created by endoscopic mucosal resection: a prospective randomized pilot study.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Anti-Ulcer Agents; Endoscopy, Gastrointestinal; Famotidine; | 2010 |
A randomized controlled trial of rebamipide plus rabeprazole for the healing of artificial ulcers after endoscopic submucosal dissection.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Alanine; Anti-Ulcer Agents; Disease Progression; Drug | 2011 |
Healing effects of rebamipide and omeprazole in Helicobacter pylori-positive gastric ulcer patients after eradication therapy: a randomized double-blind, multinational, multi-institutional comparative study.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Clar | 2011 |
Contributing factors to gastric ulcer healing after endoscopic submucosal dissection including the promoting effect of rebamipide.
Topics: Aged; Aged, 80 and over; Alanine; Anti-Ulcer Agents; Drug Therapy, Combination; Endoscopy, Digestive | 2012 |
Can rebamipide and proton pump inhibitor combination therapy promote the healing of endoscopic submucosal dissection-induced ulcers? A randomized, prospective, multicenter study.
Topics: Adenoma; Aged; Alanine; Anti-Ulcer Agents; Carcinoma; Chi-Square Distribution; Confidence Intervals; | 2012 |
Effects of rebamipide, a gastro-protective drug on the Helicobacter pylori status and inflammation in the gastric mucosa of patients with gastric ulcer: a randomized double-blind placebo-controlled multicentre trial.
Topics: Adult; Aged; Alanine; Anti-Ulcer Agents; Double-Blind Method; Female; Gastric Mucosa; Gastritis; Hel | 2003 |
A pilot study to evaluate a new combination therapy for gastric ulcer: Helicobacter pylori eradication therapy followed by gastroprotective treatment with rebamipide.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Alanine; Amoxicillin; Anti- | 2006 |
Assessing the efficacy of famotidine and rebamipide in the treatment of gastric mucosal lesions in patients receiving long-term NSAID therapy (FORCE--famotidine or rebamipide in comparison by endoscopy).
Topics: Adult; Aged; Alanine; Anti-Ulcer Agents; Endoscopy, Gastrointestinal; Famotidine; Female; Gastric Mu | 2006 |
Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Alanine; Amoxicillin; Anti-Bacterial Agents; Anti-Ul | 2007 |
Rebamipide protects against indomethacin-induced gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled study.
Topics: Adult; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Cytokines; | 1998 |
Rebamipide prevents recurrence of gastric ulcers without affecting Helicobacter pylori status.
Topics: Aged; Alanine; Anti-Ulcer Agents; Female; Helicobacter Infections; Helicobacter pylori; Humans; Male | 1998 |
Effects of rebamipide in combination with lansoprazole and amoxicillin on Helicobacter pylori-infected gastric ulcer patients.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Alanine; Amoxicillin; Anti-Ulcer Agents; Diterpenes; | 1998 |
Effect of rebamipide on Helicobacter pylori infection in patients with peptic ulcer.
Topics: Adult; Aged; Alanine; Amoxicillin; Anti-Ulcer Agents; Drug Therapy, Combination; Duodenal Ulcer; Fem | 1998 |
Rebamipide prevents occurrence of gastric lesions following transcatheter arterial embolization in the hepatic artery.
Topics: Adult; Aged; Alanine; Carcinoma, Hepatocellular; Embolization, Therapeutic; Esophageal and Gastric V | 1999 |
[Protective effect of rebamipide (OPC-12759) on the gastric mucosa in rats and humans].
Topics: Adult; Alanine; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Double-Blind Method; G | 1991 |
39 other studies available for alanine and Stomach Ulcer
| Article | Year |
|---|---|
Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies.
Topics: Alanine; Animals; Biological Availability; Biological Products; Carrageenan; Chemical Engineering; C | 2021 |
Rebamipide solution: a novel submucosal injection material to promote healing speed and healing quality of ulcers induced by endoscopic submucosal dissection.
Topics: Alanine; Animals; Anti-Ulcer Agents; Endoscopic Mucosal Resection; Female; Fibrosis; Gastric Mucosa; | 2018 |
The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: comparison study with rebamipide.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Carnosin | 2013 |
Protective effects of garlic extract, PMK-S005, against nonsteroidal anti-inflammatory drugs-induced acute gastric damage in rats.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dose-Response Relation | 2014 |
Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Gastric Acid; Gas | 2014 |
Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents.
Topics: Alanine; Animals; Anti-Ulcer Agents; Artemisia; Coumarins; Ethanol; Hydrochloric Acid; Indomethacin; | 2015 |
[Evaluation of Gastric Mucosal Injury Model Animals of Rebamipide Formulation--Study of Therapeutic Equivalence].
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal | 2016 |
Complementarity of in vitro and in vivo models for the evaluation of gastro-protective effects of pharmacological substances.
Topics: Alanine; Animals; Anti-Ulcer Agents; Cimetidine; Dose-Response Relationship, Drug; Gastric Mucosa; I | 2017 |
Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5'-AMP-activated protein kinase.
Topics: Alanine; AMP-Activated Protein Kinases; Animals; Anti-Ulcer Agents; Cyclooxygenase 2; Dinoprostone; | 2017 |
Antral ulcers induced by alendronate, a nitrogen-containing biphophonate, in rat stomachs - prophylactic effect of rebamipide.
Topics: Alanine; Alendronate; Animals; Anti-Ulcer Agents; Antioxidants; Bone Density Conservation Agents; Do | 2009 |
Rebamipide: a gastrointestinal protective drug with pleiotropic activities.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Alendronate; Allopurinol; Animals; Anti-Inflammatory Agents | 2010 |
Rebamipide prevents delay of acetic acid-induced gastric ulcer healing caused by Helicobacter pylori infection in Mongolian gerbils.
Topics: Acetic Acid; Alanine; Animals; Anti-Ulcer Agents; Apoptosis; Cell Division; Epithelium; Gerbillinae; | 2002 |
Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor.
Topics: Acetic Acid; Alanine; Animals; Anti-Ulcer Agents; Cyclooxygenase 2; Gastric Mucosa; Glyceraldehyde-3 | 2003 |
Rebamipide binds to iNOS-positive cells in acetic acid-treated but not in ethanol-treated rat gastric mucosa.
Topics: Acetic Acid; Alanine; Animals; Anti-Ulcer Agents; Binding Sites; Ethanol; Gastric Mucosa; Indicators | 2003 |
NONPROTEOLYTIC ENZYMES IN GASTRIC JUICE.
Topics: Alanine; Alkaline Phosphatase; Anemia; Anemia, Pernicious; Aspartate Aminotransferases; Duodenal Ulc | 1963 |
Rebamipide reduces delay in gastric ulcer healing in cyclooxygenase-2-deficient mice.
Topics: Alanine; Animals; Anti-Ulcer Agents; Cyclooxygenase 2; Gene Expression Profiling; Immunohistochemist | 2005 |
Rebamipide reduces recurrence of experimental gastric ulcers: role of free radicals and neutrophils.
Topics: Acetic Acid; Alanine; Animals; Anti-Ulcer Agents; Free Radicals; Gastric Mucosa; Glutathione Peroxid | 2005 |
Prophylactic effect of rebamipide against the irritative and healing impairment actions of alendronate in rat stomachs.
Topics: Acetic Acid; Administration, Oral; Alanine; Alendronate; Animals; Anti-Ulcer Agents; Blotting, Weste | 2007 |
Vulnerability of gastric mucosa to prednisolone in rats chronically exposed to cigarette smoke.
Topics: Alanine; Animals; Anti-Ulcer Agents; Blood Gas Analysis; Dinoprostone; Disease Models, Animal; Gastr | 2008 |
Chromatographic analysis of free amino acids of gastric juice in patients with cancer and other stomach diseases.
Topics: Adult; Alanine; Amino Acids; Arginine; Aspartic Acid; Chromatography; Cystine; Duodenal Ulcer; Femal | 1967 |
Preventive effect of rebamipide on gastric lesions induced by ischemia-reperfusion in the rat.
Topics: Alanine; Animals; Anti-Ulcer Agents; Chemotaxis, Leukocyte; Free Radical Scavengers; Gastric Mucosa; | 1995 |
Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine.
Topics: Acetates; Acetic Acid; Alanine; Animals; Anti-Ulcer Agents; Cimetidine; Drug Therapy, Combination; M | 1995 |
Active oxygen species in formation of acute gastric mucosal lesions induced by thermal injury in rats.
Topics: Acute Disease; Alanine; Analysis of Variance; Animals; Anti-Ulcer Agents; Burns; Drug Evaluation, Pr | 1995 |
Effect of rebamipide on lipid peroxidation and gastric mucosal injury induced by indometacin in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Free Radicals; Gastric Mucosa; Indomethacin; Lipid Peroxidation | 1993 |
The effect of rebamipide on gastric xanthine oxidase activity and type conversion in ethanol-treated rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Enzyme Inhibitors; Ethanol; Free Radicals; Lipid Peroxidation; | 1996 |
Protective effect of taurine on indomethacin-induced gastric mucosal injury.
Topics: Adult; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Adhesion; | 1996 |
Protective effect of rebamipide against ammonia-induced gastric mucosal lesions.
Topics: Alanine; Ammonia; Animals; Anti-Ulcer Agents; Antioxidants; Gastric Mucosa; Male; Prostaglandins; Qu | 1998 |
Rebamipide treatment activates epidermal growth factor and its receptor expression in normal and ulcerated gastric mucosa in rats: one mechanism for its ulcer healing action?
Topics: Alanine; Animals; Anti-Ulcer Agents; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors | 1998 |
Rebamipide prevents indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in rats.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Calcium; Gastric Mucos | 1998 |
Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils.
Topics: Alanine; Animals; Anti-Ulcer Agents; Gastric Mucosa; Gerbillinae; Helicobacter Infections; Helicobac | 1998 |
Effect of rebamipide on the glycosaminoglycan content of the ulcerated rat stomach.
Topics: Alanine; Analysis of Variance; Animals; Anti-Ulcer Agents; Chromatography, Gel; Glycosaminoglycans; | 1998 |
Combined effect of rebamipide and ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells.
Topics: Abietanes; Alanine; Anti-Ulcer Agents; Bacterial Adhesion; Cell Line; Diterpenes; Drug Synergism; Ep | 2000 |
Induction of cyclooxygenase-2 in rat gastric mucosa by rebamipide, a mucoprotective agent.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase 1; Cycl | 2000 |
Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Cytochrome c Group; Ditiocarb; Gastric Mucosa; Lipid Peroxidati | 1992 |
Effects of various mucosal protective drugs on diethyldithiocarbamate-induced antral ulcer in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Ditiocarb; Male; Pyloric Antrum; Quinolones; Rats; Rats, Inbred | 1991 |
Effect of OPC-12759, a novel antiulcer agent, on chronic and acute experimental gastric ulcer, and gastric secretion in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Gastric Mucosa; Male; Perfusion; Quinolones; Rats; Rats, Inbred | 1989 |
[Healing promoting effect of proamipide, a novel drug that increases gastric defense mechanisms, on acetic acid-induced gastric ulcers in the rat].
Topics: Acetates; Alanine; Animals; Anti-Ulcer Agents; Fibrosis; Gastric Mucosa; Granulation Tissue; Male; Q | 1988 |
Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. Synthesis and antiulcer activities of optically active alpha-amino acid derivatives of 2(1H)-quinolinone and oxindole.
Topics: Alanine; Animals; Anti-Ulcer Agents; Indoles; Quinolines; Quinolones; Rats; Stomach Ulcer; Structure | 1987 |
[Nitrogen metabolism in parenteral feeding].
Topics: Adult; Aged; Alanine; Amino Acids; Ammonia; Creatinine; Diet Therapy; Duodenal Ulcer; Female; Glycin | 1971 |