Page last updated: 2024-11-08

alanine and Pregnancy

alanine has been researched along with Pregnancy in 344 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"When started in pregnancy, dolutegravir-containing regimens had superior virological efficacy at delivery compared with the efavirenz, emtricitabine, and tenofovir disoproxil fumarate regimen."9.41Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2 ( Amico, KR; Brummel, SS; Cassim, H; Chakhtoura, N; Chinula, L; Coletti, A; Currier, J; Fairlie, L; Frenkel, LM; Hanley, S; Hoffman, RM; Holmes, LB; Jean-Philippe, P; João, E; Johnston, B; Korutaro, V; Krotje, C; Lockman, S; Masheto, G; McCarthy, K; Mmbaga, BT; Momper, JD; Moyo, S; Purdue, L; Rooney, JF; Sax, PE; Shapiro, RL; Stranix-Chibanda, L; Stringer, JS; Thoofer, NK; Ziemba, L, 2021)
"Integrase inhibitors, including dolutegravir (DTG), are associated with weight gain and obesity, especially when combined with tenofovir alafenamide (TAF)."9.12The predicted risk of adverse pregnancy outcomes as a result of treatment-associated obesity in a hypothetical population receiving tenofovir alafenamide/emtricitabine/dolutegravir, tenofovir disoproxil fumarate/emtricitabine/dolutegravir or tenofovir dis ( Asif, S; Baxevanidi, E; Chandiwana, N; Fairlie, L; Hill, A; Masenya, M; Serenata, C; Sokhela, S; Venter, WDF, 2021)
"Tenofovir alafenamide (TAF) has recently been approved for chronic hepatitis B (CHB)."8.95Tenofovir alafenamide as compared to tenofovir disoproxil fumarate in the management of chronic hepatitis B with recent trends in patient demographics. ( Hsu, YC; Nguyen, MH; Wei, MT, 2017)
"Tenofovir alafenamide (TAF), a prodrug of tenofovir (TFV), is included in the majority of the recommended first-line antiretroviral regimens for patients living with human immunodeficiency virus (HIV), but there are limited data on TAF use in pregnant women."8.12Tenofovir Alafenamide Plasma Concentrations Are Reduced in Pregnant Women Living With Human Immunodeficiency Virus (HIV): Data From the PANNA Network. ( Alba Alejandre, I; Bukkems, VE; Burger, D; Colbers, A; Garcia, C; Hidalgo Tenorio, C; Konopnicki, D; Lambert, JS; Necsoi, C; Richel, O; Te Brake, LHM; van der Meulen, E; van Hulzen, A; Weiss, F, 2022)
"Antenatal antiviral therapy (AVT) is effective in preventing mother-to-child transmission (MTCT) in chronic hepatitis B (CHB); tenofovir disoproxil fumarate (TDF) is the preferred agent."8.12Plasma and breast milk pharmacokinetics of tenofovir alafenamide in mothers with chronic hepatitis B infection. ( Cottrell, M; Crane, H; Di Girolamo, J; Dumond, J; Gane, E; Kashuba, A; Kayes, T; Levy, MT; Lim, TH; Manandhar, S; Symonds, A, 2022)
"This study aims to investigate the effect of resveratrol on intrahepatic cholestasis of pregnancy (ICP) and its effect on the gut microbiome profiles, thus contributing to the potential therapeutic strategies for ICP."8.12Resveratrol modulates the gut microbiota of cholestasis in pregnant rats. ( Lei, L; Li, Z; Ling, L; Liu, Y; Shao, Y; Xiong, Z, 2022)
"Few safety and effectiveness results have been published regarding the administration of tenofovir alafenamide fumarate (TAF) during pregnancy for the prevention of mother-to-child transmission (MTCT) of hepatitis B virus (HBV)."8.02Tenofovir Alafenamide to Prevent Perinatal Hepatitis B Transmission: A Multicenter, Prospective, Observational Study. ( Chen, ZM; Cui, GL; Ji, F; Li, GM; Li, J; Li, W; Li, ZQ; Liang, HX; Liu, YM; Lv, J; Pan, YJ; Sun, CY; Wang, FS; Xu, JH; Yu, ZJ; Zeng, QL; Zhang, DW; Zhang, GF, 2021)
"2% (wt:wt) L-alanine (isonitrogenous control) throughout pregnancy (Expt."7.74Dietary arginine supplementation during early pregnancy enhances embryonic survival in rats. ( Fan, X; Li, P; Wang, F; Wang, J; Wu, G; Yang, W; Yin, Y; Zeng, X; Zhou, B, 2008)
"To evaluate the possible association between plasma total homocysteine or other amino acid concentrations and gestational diabetes or glucose intolerance (GI), in normotensive and preeclamptic pregnant women."7.73Are plasma total homocysteine and other amino acids associated with glucose intolerance in uncomplicated pregnancies and preeclampsia? ( Antònia Vilaseca, M; Gómez, E; Lailla, JM; López-Quesada, E, 2005)
"A mutation in the gene 5,10-methylenetetrahydrofolate reductase (MTHFR), leading to altered homocysteine metabolism, has been identified in parents and fetuses with fetal neural tube defects."7.70Role of amniotic fluid homocysteine level and of fetal 5, 10-methylenetetrahydrafolate reductase genotype in the etiology of neural tube defects. ( Acton, S; Johanning, GL; Johnston, KE; Owen, J; Tamura, T; Wenstrom, KD, 2000)
"The participation of the liver to the increase in alanine utilization seen at midpregnancy was studied in 9- and 12-day pregnant rats."7.67Alanine uptake by liver at midpregnancy in rats. ( Bourdel, G; Pastor-Anglada, M; Remesar, X, 1987)
"In order to quantify the glucose-alanine relationship in normal human pregnancy, the turnover rates of alanine and the incorporation of alanine carbon into glucose were quantified in 15 pregnant women during the last 4 weeks of gestation following a ten-hour fast."7.67Glucose-alanine relationship in normal human pregnancy. ( Gilfillan, CA; Kalhan, SC; Savin, SM; Tserng, KY, 1988)
"To determine if pancreatic glucoregulatory hormones can be implicated in the glucose fall of pregnancy, we have measured plasma immunoreactive insulin and glucagon (IRI and IRG) in rats."7.65Plasma glucagon and insulin in rat pregnancy. Roles in glucose homeostasis. ( Finkowski, M; Knopp, RH; Saudek, CD, 1975)
"Pantetheine 4'-phosphate was significantly negatively associated with non-high-density lipoprotein (non-HDL) and TC levels."5.91Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring. ( Liu, Y; Luo, T; Meng, X; Yu, G; Zhang, J; Zhang, R, 2023)
"When started in pregnancy, dolutegravir-containing regimens had superior virological efficacy at delivery compared with the efavirenz, emtricitabine, and tenofovir disoproxil fumarate regimen."5.41Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2 ( Amico, KR; Brummel, SS; Cassim, H; Chakhtoura, N; Chinula, L; Coletti, A; Currier, J; Fairlie, L; Frenkel, LM; Hanley, S; Hoffman, RM; Holmes, LB; Jean-Philippe, P; João, E; Johnston, B; Korutaro, V; Krotje, C; Lockman, S; Masheto, G; McCarthy, K; Mmbaga, BT; Momper, JD; Moyo, S; Purdue, L; Rooney, JF; Sax, PE; Shapiro, RL; Stranix-Chibanda, L; Stringer, JS; Thoofer, NK; Ziemba, L, 2021)
"Valproic acid is an anticonvulsant widely used for the treatment of epilepsy."5.31Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). ( Matsuo, H; Nakano, H; Ohtani, H; Sawada, Y; Takanaga, H; Tsukimori, K; Ushigome, F, 2001)
"These data indicate that intrauterine growth retardation has profound effects on postnatal growth and metabolism."5.27Altered growth, hypoglycemia, hypoalaninemia, and ketonemia in the young rat: postnatal consequences of intrauterine growth retardation. ( Bussey, ME; Finley, S; LaBarbera, A; Ogata, ES, 1985)
" Ulipristal for uterine fibroids : market withdrawal due to risk of severe liver injury."5.12[Pharmacovigilance update]. ( Ekobena, P; Ivanyuk, A; Livio, F, 2021)
"Integrase inhibitors, including dolutegravir (DTG), are associated with weight gain and obesity, especially when combined with tenofovir alafenamide (TAF)."5.12The predicted risk of adverse pregnancy outcomes as a result of treatment-associated obesity in a hypothetical population receiving tenofovir alafenamide/emtricitabine/dolutegravir, tenofovir disoproxil fumarate/emtricitabine/dolutegravir or tenofovir dis ( Asif, S; Baxevanidi, E; Chandiwana, N; Fairlie, L; Hill, A; Masenya, M; Serenata, C; Sokhela, S; Venter, WDF, 2021)
"Tenofovir alafenamide (TAF) has recently been approved for chronic hepatitis B (CHB)."4.95Tenofovir alafenamide as compared to tenofovir disoproxil fumarate in the management of chronic hepatitis B with recent trends in patient demographics. ( Hsu, YC; Nguyen, MH; Wei, MT, 2017)
"Tenofovir alafenamide (TAF), a prodrug of tenofovir (TFV), is included in the majority of the recommended first-line antiretroviral regimens for patients living with human immunodeficiency virus (HIV), but there are limited data on TAF use in pregnant women."4.12Tenofovir Alafenamide Plasma Concentrations Are Reduced in Pregnant Women Living With Human Immunodeficiency Virus (HIV): Data From the PANNA Network. ( Alba Alejandre, I; Bukkems, VE; Burger, D; Colbers, A; Garcia, C; Hidalgo Tenorio, C; Konopnicki, D; Lambert, JS; Necsoi, C; Richel, O; Te Brake, LHM; van der Meulen, E; van Hulzen, A; Weiss, F, 2022)
"Tenofovir alafenamide (TAF) is a key component of HIV treatment, but pharmacokinetic data supporting the use of TAF during pregnancy are limited."4.12Pharmacokinetics of Tenofovir Alafenamide With Boosted Protease Inhibitors in Pregnant and Postpartum Women Living With HIV: Results From IMPAACT P1026s. ( Barr, E; Best, BM; Brooks, KM; Browning, R; Capparelli, EV; Chakhtoura, N; Deville, JG; Febo, IL; George, K; Knowles, K; Mirochnick, M; Paul, ME; Pinilla, M; Rungruengthanakit, K; Shapiro, DE; Stek, AM, 2022)
" Female ICR mice were fed a control (20% casein), a low-protein (10% casein), a low-protein with 2% BCAAs or a low-protein with 2% alanine diet for 2 weeks before mating and then throughout pregnancy and lactation."4.12Effects of maternal branched-chain amino acid and alanine supplementation on growth and biomarkers of protein metabolism in dams fed a low-protein diet and their offspring. ( Choi, A; Choi, W; Kim, J; Ko, JW; Kwon, YH, 2022)
"Antenatal antiviral therapy (AVT) is effective in preventing mother-to-child transmission (MTCT) in chronic hepatitis B (CHB); tenofovir disoproxil fumarate (TDF) is the preferred agent."4.12Plasma and breast milk pharmacokinetics of tenofovir alafenamide in mothers with chronic hepatitis B infection. ( Cottrell, M; Crane, H; Di Girolamo, J; Dumond, J; Gane, E; Kashuba, A; Kayes, T; Levy, MT; Lim, TH; Manandhar, S; Symonds, A, 2022)
"This study aims to investigate the effect of resveratrol on intrahepatic cholestasis of pregnancy (ICP) and its effect on the gut microbiome profiles, thus contributing to the potential therapeutic strategies for ICP."4.12Resveratrol modulates the gut microbiota of cholestasis in pregnant rats. ( Lei, L; Li, Z; Ling, L; Liu, Y; Shao, Y; Xiong, Z, 2022)
"Few safety and effectiveness results have been published regarding the administration of tenofovir alafenamide fumarate (TAF) during pregnancy for the prevention of mother-to-child transmission (MTCT) of hepatitis B virus (HBV)."4.02Tenofovir Alafenamide to Prevent Perinatal Hepatitis B Transmission: A Multicenter, Prospective, Observational Study. ( Chen, ZM; Cui, GL; Ji, F; Li, GM; Li, J; Li, W; Li, ZQ; Liang, HX; Liu, YM; Lv, J; Pan, YJ; Sun, CY; Wang, FS; Xu, JH; Yu, ZJ; Zeng, QL; Zhang, DW; Zhang, GF, 2021)
"Heterozygous in frame trinucleotide duplications within the PHOX2B gene, leading to poly-alanine expansions, cause Congenital Central Hypoventilation Syndrome."3.80Recurrence of CCHS associated PHOX2B poly-alanine expansion mutation due to maternal mosaicism. ( Bachetti, T; Ceccherini, I; Della Monica, M; Di Duca, M; Grappone, L; Scarano, G, 2014)
" Using a swine model, we tested the hypothesis that dietary L-arginine supplementation during gestation may improve pregnancy outcomes through enhancing placental growth and modulating hormonal secretions."3.78Dietary L-arginine supplementation enhances placental growth and reproductive performance in sows. ( Chen, F; Gao, K; Jiang, Z; Lin, Y; Wu, G; Yang, L; Zheng, C; Zhou, G, 2012)
"2% (wt:wt) L-alanine (isonitrogenous control) throughout pregnancy (Expt."3.74Dietary arginine supplementation during early pregnancy enhances embryonic survival in rats. ( Fan, X; Li, P; Wang, F; Wang, J; Wu, G; Yang, W; Yin, Y; Zeng, X; Zhou, B, 2008)
"To evaluate the possible association between plasma total homocysteine or other amino acid concentrations and gestational diabetes or glucose intolerance (GI), in normotensive and preeclamptic pregnant women."3.73Are plasma total homocysteine and other amino acids associated with glucose intolerance in uncomplicated pregnancies and preeclampsia? ( Antònia Vilaseca, M; Gómez, E; Lailla, JM; López-Quesada, E, 2005)
"Most (85%) women received highly active antiretroviral therapy (HAART) during pregnancy (mean duration: 31 weeks) and zidovudine during labor (93%)."3.72Hyperlactatemia in human immunodeficiency virus-uninfected infants who are exposed to antiretrovirals. ( Artuch, R; Fortuny, C; Jimenez, R; Muñoz-Almagro, C; Noguera, A; Pou, J; Sanchez, E; Vilaseca, MA, 2004)
"To evaluate the effects of epidermal growth factor (EGF) on placental amino acids uptake, transport activities for L-proline, L-leucine, and L-alanine were kinetically examined in placental microvillous vesicles(PMV) obtained from pregnant rats administered with EGF(100 and 200 microg/kg/day) from day 18 to 21 of pregnancy."3.71Effects of epidermal growth factor on placental amino acids uptake in pregnant rats. ( Bonkobara, M; Inaba, M; Matsuki, N; Ohmori, T; Ono, K; Thongsong, B, 2002)
"A specific gene mutation leading to altered homocysteine metabolism has been identified in parents and fetuses with neural tube defects (NTDs)."3.70Amniotic fluid homocysteine levels, 5,10-methylenetetrahydrafolate reductase genotypes, and neural tube closure sites. ( Acton, S; Cliver, S; Johanning, GL; Johnston, KE; Owen, J; Tamura, T; Wenstrom, KD, 2000)
"A mutation in the gene 5,10-methylenetetrahydrofolate reductase (MTHFR), leading to altered homocysteine metabolism, has been identified in parents and fetuses with fetal neural tube defects."3.70Role of amniotic fluid homocysteine level and of fetal 5, 10-methylenetetrahydrafolate reductase genotype in the etiology of neural tube defects. ( Acton, S; Johanning, GL; Johnston, KE; Owen, J; Tamura, T; Wenstrom, KD, 2000)
"To better define the glucose-alanine relationship and hepatic alanine metabolism during pregnancy, glucose and alanine turnover rates (TR) and simultaneous hepatic alanine uptake were determined in nine term pregnant (P) and 12 nonpregnant (NP) rabbits who had undergone chronic catheterization of both the systemic and hepatic circulations."3.69Plasma disposal rate and hepatic alanine metabolism in pregnant and nonpregnant rabbits. ( Battaglia, FC; Briggs, K; Fennessey, PV; Thureen, PJ, 1995)
" Levels of the gluconeogenic precursors alanine and lactate were increased during pregnancy in both the women without IDDM (from 0."3.69Glucose turnover and gluconeogenesis during pregnancy in women with and without insulin-dependent diabetes mellitus. ( Bourque, J; Chiasson, JL; Ducros, F; el Achkar, GG; Maheux, P, 1997)
"At mid pregnancy (12th day) fed rats exhibit a drop of blood alanine level when the weight of the fetoplacental unit is still negligible."3.67Alanine turnover rate and its hepatic metabolism are increased in midpregnant rat. ( Champigny, O; Ferré, P; Girard, J; Pastor-Anglada, M; Remesar, X, 1988)
"In order to quantify the glucose-alanine relationship in normal human pregnancy, the turnover rates of alanine and the incorporation of alanine carbon into glucose were quantified in 15 pregnant women during the last 4 weeks of gestation following a ten-hour fast."3.67Glucose-alanine relationship in normal human pregnancy. ( Gilfillan, CA; Kalhan, SC; Savin, SM; Tserng, KY, 1988)
"The participation of the liver to the increase in alanine utilization seen at midpregnancy was studied in 9- and 12-day pregnant rats."3.67Alanine uptake by liver at midpregnancy in rats. ( Bourdel, G; Pastor-Anglada, M; Remesar, X, 1987)
"L-Alanosine [L-2-amino-3(N-hydroxy-N-nitrosamino)propionic acid], a tumor-inhibiting agent, induces pregnancy arrest after single or multiple SC or PO administration to rats and hamsters."3.67Contragestational profile of the tumor-inhibiting agent, L-alanosine, in the rat and the hamster. ( Assandri, A; Barone, D; Galliani, G; Grandi, M; Lancini, GC; Mistrello, G, 1985)
"Pancreatic alpha cell response to oral alanine was assessed in the third trimester of pregnancy and in the puerperium in 16 insulin-dependent diabetic and 7 normal pegnant women."3.66Pancreatic alpha cell response to alanine during and after normal and diabetic pregnancies. ( Aoki, TT; Gleason, R; Hare, JW; Jewett, JF; Kitzmiller, JL; Soeldner, JS; Tabatabaii, A; Tanenberg, RJ, 1980)
"The time-courses of liver glycogen, plasma glucose, lactate, alanine and glycerol concentrations in term and preterm rats undergoing hypothermia (30 degrees C) during the first 2 h after delivery have been studied."3.66Prematurity in the rat. II. Effect of hypothermia. ( Benito, M; Cuezva, JM; Medina, JM; Moreno, FJ, 1980)
" Permanent metabolic acidosis due to lactic acidemia as well as hyperpyruvic acidemia and hyperalaninemia were present."3.66[Pyruvate-dehydrogenase deficiency. Lethal course of the disease during infancy (author's transl)]. ( Becker, K; Berger, R; Bremer, HJ; Przyrembel, H; Walther, B; Wendel, U, 1978)
"The responses of plasma insulin and the C-peptide of proinsulin, glucose, lactate, free fatty acids (FFA), glycerol, D-beta-hydroxybutyrate and alanine to a beta2-adrenergic agonist (salbutamol) were determined in 5 patients during the last trimester of pregnancy before labor."3.65The immediate effect of a beta-adrenergic agonist (salbutamol) on carbohydrate and lipid metabolism during the third trimester of pregnancy. ( Joelsson, I; Larsson, A; Lunell, NO; Persson, B, 1977)
"To determine if pancreatic glucoregulatory hormones can be implicated in the glucose fall of pregnancy, we have measured plasma immunoreactive insulin and glucagon (IRI and IRG) in rats."3.65Plasma glucagon and insulin in rat pregnancy. Roles in glucose homeostasis. ( Finkowski, M; Knopp, RH; Saudek, CD, 1975)
" Rats were mated and at weekly intervals during pregnancy and lactation, and after weaning, the dipeptidase activity in the supernatant fraction from small intestinal mucosa extracts was determined for two dipeptides: glycyl-L-leucine dipeptidase (EC 3."3.65Dipeptidase activity in the small intestinal mucosa during pregnancy and lactation in the rat. ( Rolls, BA, 1975)
"Fetal mice treated on days 10, 11, and 12 of gestation by injecting the mothers with (i) 50 milligrams of beta-2-thienylalanine, (ii) solvent, or (iii) sham injection had identical frequencies of audiogenic seizures when tested 23 days after birth; these frequencies were significantly higher than those of an unhandled control group."3.65Suceptibility of mice to audiogenic seizures is increased by handling their dams during gestation. ( Beck, SL; Gavin, DL, 1976)
" The effect of pregnancy on the glycemic response to exogenous alanine administration during starvation was also investigated."3.65Amino acid metabolism during starvation in human pregnancy. ( Felig, P; Hendler, R; Kim, YJ; Lynch, V, 1972)
"Pantetheine 4'-phosphate was significantly negatively associated with non-high-density lipoprotein (non-HDL) and TC levels."1.91Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring. ( Liu, Y; Luo, T; Meng, X; Yu, G; Zhang, J; Zhang, R, 2023)
"Glycine at 10-14 GW was inversely associated with GDM (adjusted OR [95% CI] per SD increment: 0."1.91Plasma Amino Acids in Early Pregnancy and Midpregnancy and Their Interplay With Phospholipid Fatty Acids in Association With the Risk of Gestational Diabetes Mellitus: Results From a Longitudinal Prospective Cohort. ( Bremer, AA; Chen, Z; Li, LJ; Lu, R; Pang, WW; Rahman, ML; Tekola-Ayele, F; Tsai, MY; Weir, NL; Wu, J; Yang, J; Zhang, C, 2023)
"Data on its use in pregnancy are limited."1.72Early Administration of Remdesivir and Intensive Care Unit Admission in Hospitalized Pregnant Individuals With Coronavirus Disease 2019 (COVID-19). ( Abdelwahab, M; Cackovic, M; Colburn, N; Costantine, MM; Day, S; Eid, J; Rood, KM, 2022)
"Pregnant women receiving TAF 10 mg with cobicistat or TAF 25 mg without boosting as part of clinical care had intensive pharmacokinetic assessments performed during the second and third trimesters, and 6-12 weeks postpartum."1.62Pharmacokinetics of tenofovir alafenamide with and without cobicistat in pregnant and postpartum women living with HIV. ( Barr, E; Best, BM; Brooks, KM; Capparelli, EV; Chakhtoura, N; Cielo, M; Denson, K; Deville, JG; Espina, R; Febo, IL; George, K; Haubrich, R; Mirochnick, M; Momper, JD; Pinilla, M; Rooney, JF; Rungruengthanakit, K; Shapiro, DE; Smith, E; Stek, AM; Weinberg, A, 2021)
"Gestational diabetes mellitus was diagnosed according to community standards."1.62Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming. ( Gornbein, JA; Koos, BJ, 2021)
" No severe adverse effects were reported in either mothers or infants."1.56Efficacy and safety of tenofovir alafenamide fumarate for preventing mother-to-child transmission of hepatitis B virus: a national cohort study. ( Cao, L; Chen, B; Chen, R; Ding, Y; Fan, J; Gan, W; Huang, Y; Lin, C; Liu, Y; Pan, CQ; Sheng, Q; Wang, S; Wang, Y; Zhu, L, 2020)
"In a sheep model of intrauterine growth restriction (IUGR) produced from placental insufficiency, late gestation fetuses had smaller skeletal muscle mass, myofiber area, and slower muscle protein accretion rates compared with normally growing fetuses."1.51Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb. ( Baker, PR; Brown, LD; Chang, EI; D'Alessandro, A; Gilje, EA; Hay, WW; Reisz, JA; Rozance, PJ; Wesolowski, SR, 2019)
"Acquired hemophilia A (AHA) is a severe life-threatening autoimmune disease due to the development of autoantibodies that neutralize the procoagulant activity of factor VIII (FVIII)."1.38The IgG autoimmune response in postpartum acquired hemophilia A targets mainly the A1a1 domain of FVIII. ( Ali, T; Balicchi, J; Borg, JY; Cayzac, C; Granier, C; Gruel, Y; Lapalud, P; Lavigne-Lissalde, G; Levesque, H; Mathieu-Dupas, E; Pfeiffer, C; Schved, JF, 2012)
" However, it was not possible to generate dose-response curves whereas significant correlations of uptake values with T50 values were found."1.31The effect of oxytocin, prostaglandin E2 and acetylsalicylic acid on flow distribution and on the transfer of alanine, glucose and water in isolated perfused guinea pig placentae. ( Goepel, E; Niemax, K; Rybakowski, C; Schröder, HJ, 2000)
"Valproic acid is an anticonvulsant widely used for the treatment of epilepsy."1.31Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). ( Matsuo, H; Nakano, H; Ohtani, H; Sawada, Y; Takanaga, H; Tsukimori, K; Ushigome, F, 2001)
"These data suggest that intrauterine growth retardation in dogs results in fasting neonatal hypoglycemia that is due in part to reduced systemic glucose production."1.28Alterations of fasting glucose and fat metabolism in intrauterine growth-retarded newborn dogs. ( Kliegman, RM, 1989)
"To elucidate the change in EPH gestosis placental amino acid transport activity, we investigated the uptake of L-alanine into microvillous membrane vesicles prepared from EPH gestosis placenta and from normal placenta by using a rapid filtration technique."1.27[The changes in EPH gestosis placental amino acid transport activity (using human placental microvillous membrane vesicles)]. ( Akazaki, M; Hino, K; Ichijo, M; Iioka, H; Itani, Y; Itoh, K; Katoh, Y; Moriyama, I; Okamura, Y, 1987)
"These data indicate that intrauterine growth retardation has profound effects on postnatal growth and metabolism."1.27Altered growth, hypoglycemia, hypoalaninemia, and ketonemia in the young rat: postnatal consequences of intrauterine growth retardation. ( Bussey, ME; Finley, S; LaBarbera, A; Ogata, ES, 1985)

Research

Studies (344)

TimeframeStudies, this research(%)All Research%
pre-1990210 (61.05)18.7374
1990's32 (9.30)18.2507
2000's34 (9.88)29.6817
2010's28 (8.14)24.3611
2020's40 (11.63)2.80

Authors

AuthorsStudies
Kim, EH1
Kim, YI1
Jang, SG1
Im, M1
Jeong, K1
Choi, YK1
Han, HJ1
Bukkems, VE1
Necsoi, C1
Hidalgo Tenorio, C1
Garcia, C1
Alba Alejandre, I1
Weiss, F1
Lambert, JS1
van Hulzen, A1
Richel, O1
Te Brake, LHM1
van der Meulen, E1
Burger, D1
Konopnicki, D1
Colbers, A1
Gandhi, RT1
Malani, PN1
Del Rio, C1
Eid, J1
Abdelwahab, M1
Colburn, N1
Day, S1
Cackovic, M1
Rood, KM1
Costantine, MM1
Brooks, KM3
Pinilla, M2
Stek, AM2
Shapiro, DE2
Barr, E2
Febo, IL2
Paul, ME1
Deville, JG2
George, K2
Knowles, K1
Rungruengthanakit, K2
Browning, R1
Chakhtoura, N3
Capparelli, EV2
Mirochnick, M3
Best, BM2
Choi, W1
Kim, J1
Ko, JW1
Choi, A1
Kwon, YH1
Kayes, T1
Crane, H1
Symonds, A1
Dumond, J1
Cottrell, M1
Di Girolamo, J1
Manandhar, S1
Lim, TH1
Gane, E1
Kashuba, A1
Levy, MT1
Marikawa, Y1
Alarcon, VB1
Chen, L1
Pi, Y1
Chang, K1
Luo, S1
Peng, Z1
Chen, M1
Yu, L1
Parveen, S1
Tiwari, A1
Singh, J1
Shah, A1
Kumar, M1
Li, Z1
Lei, L1
Ling, L1
Liu, Y3
Xiong, Z1
Shao, Y1
Yang, J1
Wu, J1
Tekola-Ayele, F1
Li, LJ1
Bremer, AA1
Lu, R1
Rahman, ML1
Weir, NL1
Pang, WW1
Chen, Z1
Tsai, MY1
Zhang, C1
Liu, XF1
Li, MD1
Lu, JJ1
Li, Y1
Zeng, AR1
Qiang, JW1
Huang, Y2
Kong, Y1
Shen, B1
Li, B2
Loor, JJ1
Tan, P1
Wei, B1
Mei, L1
Zhang, Z1
Zhao, C1
Zhu, X1
Qi, S1
Wang, J2
Yang, Q1
Song, J1
Deng, Z1
Shi, C1
Li, S1
Zhuang, G1
Hao, H1
Cai, Y1
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Paul, BB1
Strauss, RR1
Sbarra, AJ1
Krvavica, S1
Martincic, T1
Coufalik, A2
Boon, WH1
Tsakok, FH1
Baird, GD1
Symonds, HW1
Ash, R1
Davis, SR1
Mepham, TB1
Felig, P3
Manchester, KL1
Epstein, MF1
Fleischman, AR1
Hutchinson, DL1
Schultze, B1
Rabbani, B1
Maurer, W1
Verbeke, R1
Roets, E1
Peeters, G1
Plaut, SM1
Davis, JM1
Jaszczak, S3
Bentyn, K1
Choroszewska, A1
Reisner, SH1
Aranda, JV1
Colle, E1
Papageorgiou, A1
Schiff, D1
Scriver, CR1
Stern, L1
Ahern, EJ1
Ahern, V1
Wiltshire, BG2
Lehmann, H3
A'zary, E2
Saifer, A2
Schneck, L2
Kendall, AG1
Barr, RD1
Lang, A1
Wise, JK1
Lyall, SS1
Hendler, R2
Agnoli, FS2
Nute, PE1
Pataryas, HA1
Stamatoyannopoulos, G1
Wapnir, RA1
Schlaeger, R1
Spellman, CM1
Gordon, N1
Marsden, HB1
Lewis, DM1
Bergman, EN1
Kaufman, CF1
Wolff, JE1
Williams, HH1
Depper, R1
Haymond, MW1
Karl, IE1
Pagliara, AS1
Sladek, CD1
Boisse, J1
Kim, YJ1
Lynch, V1
Hafez, ES2
Moghissi, KS1
Kurrie, DA1
Wen, CP1
Gershoff, SN1
Cheyne, GA1
Scott, CR1
Teng, CC1
Sagerson, RN1
Nelson, T1
Filer, LJ1
Baker, GL1
Clark, KG1
Lorkin, PA1
Brunel, C1
Cathala, G1
Reid, DW1
Campbell, DJ1
Yakymyshyn, LY1
Piccoli, F1
Grynbaum, A1
Lajtha, A1
Turner, GC1
Field, AM1
Lasheen, RM1
Tood, RM1
White, GB1
Porter, AA1
Burns, DJ1
Engel, LL1
Bethune, JL1
Normand, IC1
Olver, RE1
Reynolds, EO1
Strang, LB1
Gruemer, HD1
Grannis, GF1
Hetland, LB1
Costantini, ML1
Barlow, GB1
Macleod, AJ1
Snipe, RM1
Beckman, L1
Beckman, G1
Mi, MP1
de Simone, J1
Meyer, ME1
Oepen, H1
Oepen, I1
Fuchs, G1
Gulyas, BJ1
Daniel, JC1
Abadom, PN1
Elson, D1
Lindblad, BS1
Valenti, C1
Dugas, MC1
Hazelwood, RL1
Lawrence, AL1
Matsuka, GKh1
Babiĭ, TP1
Skvirskaia, EB1
Kovalenko, MI1
El'skaia, AV1
Nedovesova, ZP1
Ovcharenko, GV1
Hutterer, F1
Roboz, J1
Sarkozi, L1
Ruhig, A1
Bacchin, P1
Zoch, E1
Müller, H1
Hopkins, L1
McFadyen, IR1
Young, M1
Björenesjö, KB1
Hahn, TJ1
Downing, SJ1
Phang, JM1
Deren, JJ1
Padykula, HA1
Wilson, TH1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacokinetic Properties of Antiretroviral and Related Drugs During Pregnancy and Postpartum[NCT00042289]1,578 participants (Actual)Observational2003-06-09Completed
Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing Versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and Their Infants[NCT03048422]Phase 3643 participants (Actual)Interventional2018-01-19Completed
Do Preoperative Carbohydrate Drinks Prevent Preoperative Catabolism in Mothers Undergoing Elective Caesarean Section? A Randomised Controlled Study[NCT03220997]200 participants (Anticipated)Interventional2017-08-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Pharmacokinetic (PK) Parameter: Infant Plasma Washout Half-life (T1/2) of ARVs and TB Drugs

Infant plasma concentrations were collected and measured during the first 9 days of life. Half-life is defined as 0.693/k, where k, the elimination rate constant, is the slope of the decline in concentrations. (NCT00042289)
Timeframe: Infant plasma samples at 2-10, 18-28, 36-72 hours and 5-9 days after birth.

Interventionhour (Median)
DTG 50mg q.d.32.8
EVG/COBI 150/150mg q.d.7.6
DRV/COBI 800/150 mg q.d.NA
EFV 600 mg q.d. (Outside THA)65.6

PK Parameter: Cord/Maternal Blood Concentration Ratio With Median (IQR) for ARVs and TB Drugs

Cord blood and maternal plasma concentrations were collected and measured at delivery, and compared as a ratio. (NCT00042289)
Timeframe: Measured at time of delivery with single cord blood and single maternal plasma sample.

Interventionunitless (Median)
DRV/RTV 600 or 800 or 900/100mg b.i.d. Then 800 or 900/100mg b.i.d. Then 600/100mg b.i.d.0.15
DTG 50mg q.d.1.25
EVG/COBI 150/150mg q.d.0.91
DRV/COBI 800/150 mg q.d.0.07
ATV/COBI 300/150 mg q.d.0.07
TFV 300mg q.d.0.88

PK Parameter: Cord/Maternal Blood Concentration Ratio With Median (Range) for ARVs and TB Drugs

Cord blood and maternal plasma concentrations were collected and measured at delivery, and compared as a ratio. For arms with zero overall participants analyzed, samples were below the limit of quantification and ratios could not be calculated. (NCT00042289)
Timeframe: Measured at time of delivery with single cord blood and single maternal plasma sample.

Interventionunitless (Median)
TAF 10mg q.d. w/COBI0.97
EFV 600 mg q.d. (Outside THA)0.67
EFV 600mg q.d.0.49
LPV/RTV Arm 3: 400/100mg b.i.d. Then 600/150mg b.i.d. Then 400/100mg b.i.d.0.2
RAL 400mg b.i.d.1.5
ETR 200mg b.i.d.0.52
MVC 150 or 300mg b.i.d.0.33
ATV/RTV Arm 2: 300/100mg q.d. Then 400/100mg q.d. Then 300/100mg q.d.0.14
TFV/ATV/RTV Arm 2: 300/300/100mg q.d. Then 300/400/100mg q.d Then 300/300/100mg q.d.0.16
NFV Arm 2: 1250mg b.i.d. Then 1875mg b.i.d. Then 1250mg b.i.d.0.19
IDV/RTV Arm 2: 400/100mg q.d. (Only THA)0.12
RPV 25mg q.d.0.55
ATV/RTV 300/100mg q.d. or TFV/ATV/RTV 300/300/100mg q.d.0.18
DRV/RTV 800/100mg q.d. or DRV/RTV 600/100mg b.i.d.0.18

Plasma Concentration for Contraceptives

Serum concentrations of the contraceptives. Note that no historical controls were provided by team pharmacologists and thus no comparisons were done for contraceptive concentrations in women using hormonal contraceptives and selected ARV drugs as compared to historical controls not using those ARV drugs. (NCT00042289)
Timeframe: Measured at 6-7 weeks after contraceptive initiation postpartum

Interventionpg/mL (Median)
ATV/RTV/TFV 300/100/300mg q.d. With ENG604
LPV/RTV 400/100 b.i.d. With ENG428
EFV 600mg q.d. With ENG125

Area Under the Curve From 0 to 12 Hours (AUC12) of ARVs for Contraceptive Arms

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. AUC12h (area-under-the-curve from 0 to 12 hours) were determined using the linear trapezoidal rule. (NCT00042289)
Timeframe: Measured at 2-12 wks postpartum before contraceptive initiation and 6-7 wks after contraceptive initiation. Blood samples were drawn pre-dose and at 0, 1, 2, 6, 8 and 12 hours post dosing.

Interventionmcg*hr/mL (Median)
Before contraceptive initiationAfter contraceptive initiation
LPV/RTV 400/100 b.i.d. With ENG115.97100.20

Area Under the Curve From 0 to 24 Hours (AUC24) of ARVs for Contraceptive Arms

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. AUC24h (area-under-the-curve from 0 to 24 hours) were determined using the linear trapezoidal rule. (NCT00042289)
Timeframe: Measured at 2-12 wks postpartum before contraceptive initiation and 6-7 wks after contraceptive initiation. Blood samples were drawn pre-dose and at 0, 1, 2, 6, 8, 12, and 24 hours post dosing.

,
Interventionmcg*hr/mL (Median)
Before contraceptive initiationAfter contraceptive initiation
ATV/RTV/TFV 300/100/300mg q.d. With ENG53.9655.25
EFV 600mg q.d. With ENG53.6456.65

Number of Women Who Met PK Target of Area Under the Curve (AUC) for ARVs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. AUC (area under the curve) were determined using the linear trapezoidal rule. See PK target in the Protocol Appendix V. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm. Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8, 12 (and 24) hours post dosing.

,
InterventionParticipants (Count of Participants)
3rd TrimesterPostpartum
EFV 600mg q.d.2021
MVC 150 or 300mg b.i.d.87

Number of Women Who Met PK Target of Area Under the Curve (AUC) for ARVs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. AUC (area under the curve) were determined using the linear trapezoidal rule. See PK target in the Protocol Appendix V. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm. Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8, 12 (and 24) hours post dosing.

,,,,,,,,,,,,,,,,,,,,,,
InterventionParticipants (Count of Participants)
2nd Trimester3rd TrimesterPostpartum
ATV/RTV Arm 1: 300/100mg q.d.11212
DRV/COBI 800/150 mg q.d.3414
DRV/RTV 600 or 800 or 900/100mg b.i.d. Then 800 or 900/100mg b.i.d. Then 600/100mg b.i.d.71622
DRV/RTV 600/100mg b.i.d.71922
DRV/RTV 800/100mg q.d.91922
DTG 50mg q.d.92023
EFV 600 mg q.d. (Outside THA)123334
ATV/RTV Arm 2: 300/100mg q.d. Then 400/100mg q.d. Then 300/100mg q.d.82927
ETR 200mg b.i.d.5137
EVG/COBI 150/150mg q.d.81018
FPV/RTV 700/100mg b.i.d.82622
IDV/RTV Arm 2: 400/100mg q.d. (Only THA)101926
LPV/RTV Arm 3: 400/100mg b.i.d. Then 600/150mg b.i.d. Then 400/100mg b.i.d.93027
ATV/COBI 300/150 mg q.d.125
NFV Arm 2: 1250mg b.i.d. Then 1875mg b.i.d. Then 1250mg b.i.d.NA1514
RAL 400mg b.i.d.113330
RPV 25mg q.d.142625
TAF 10mg q.d. w/COBI152322
TAF 25mg q.d.132324
TAF 25mg q.d. w/COBI or RTV Boosting102418
TFV 300mg q.d.22727
TFV/ATV/RTV Arm 1: 300/300/100mg q.d.11112
TFV/ATV/RTV Arm 2: 300/300/100mg q.d. Then 300/400/100mg q.d Then 300/300/100mg q.d.72332

Pharmacokinetic (PK) Parameter: Infant Plasma Washout Concentration of ARVs and TB Drugs

Infant plasma concentrations were collected and measured during the first 9 days of life. (NCT00042289)
Timeframe: Blood samples were collected at 2-10, 18-28, 36-72 hours and 5-9 days after birth.

,,,
Interventionmcg/mL (Median)
2-10 hours after birth18-28 hours after birth36-72 hours after birth5-9 days after birth
DRV/COBI 800/150 mg q.d.0.351.431.871.72
DTG 50mg q.d.1.731.531.000.06
EFV 600 mg q.d. (Outside THA)1.11.00.90.4
EVG/COBI 150/150mg q.d.0.1320.0320.0050.005

PK Parameter: Area Under the Curve From 0 to 12 Hours (AUC12) With Geometric Mean (95% CI) for ARVs and TB Drugs

Measured in 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks, or 6-12 wks postpartum depending on study arm. Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8, and 12 hrs post dosing. (NCT00042289)
Timeframe: Measured in 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks, or 6-12 wks postpartum depending on study arm. Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8, and 12 hrs post dosing.

Interventionng*hour/mL (Geometric Mean)
2nd Trimester3rd TrimesterPostpartum
MVC 150 or 300mg b.i.d.NA27173645

PK Parameter: Area Under the Curve From 0 to 12 Hours (AUC12) With Median (IQR) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. AUC12 (area under the curve from 0 to 12 hours) were determined using the linear trapezoidal rule. (NCT00042289)
Timeframe: Measured in 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks, or 6-12 wks postpartum depending on study arm. Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8, and 12 hrs post dosing.

,,,
Interventionmg*hour/L (Median)
2nd Trimester3rd TrimesterPostpartum
DRV/RTV 600 or 800 or 900/100mg b.i.d. Then 800 or 900/100mg b.i.d. Then 600/100mg b.i.d.55.151.879.6
DRV/RTV 600/100mg b.i.d.45.845.961.7
FPV/RTV 700/100mg b.i.d.43.5032.1551.60
NFV Arm 2: 1250mg b.i.d. Then 1875mg b.i.d. Then 1250mg b.i.d.NA34.233.5

PK Parameter: Area Under the Curve From 0 to 12 Hours (AUC12) With Median (Range) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. AUC12 (area under the curve from 0 to 12 hours) were determined using the linear trapezoidal rule. (NCT00042289)
Timeframe: Measured in 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks, or 6-12 wks postpartum depending on study arm. Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8, and 12 hrs post dosing.

,,,
Interventionmg*hour/L (Median)
2nd Trimester3rd TrimesterPostpartum
ETR 200mg b.i.d.4.58.35.3
IDV/RTV Arm 2: 400/100mg q.d. (Only THA)14.916.127.1
LPV/RTV Arm 3: 400/100mg b.i.d. Then 600/150mg b.i.d. Then 400/100mg b.i.d.7296133
RAL 400mg b.i.d.6.65.411.6

PK Parameter: Area Under the Curve From 0 to 24 Hours (AUC24) With Median (IQR) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. AUC24 (area under the curve from 0 to 24 hours) were determined using the linear trapezoidal rule. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm. Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8, 12 and 24 hours post dosing.

,,,,,,,,,,,,,
Interventionmg*hour/L (Median)
2nd Trimester3rd TrimesterPostpartum
ATV/COBI 300/150 mg q.d.25.3318.8536.20
ATV/RTV Arm 1: 300/100mg q.d.88.241.957.9
ATV/RTV Arm 2: 300/100mg q.d. Then 400/100mg q.d. Then 300/100mg q.d.30.645.748.8
DRV/COBI 800/150 mg q.d.50.0042.0595.55
DRV/RTV 800/100mg q.d.64.663.5103.9
DTG 50mg q.d.47.649.265.0
EFV 600 mg q.d. (Outside THA)47.3060.0262.70
EVG/COBI 150/150mg q.d.15.314.021.0
TAF 10mg q.d. w/COBI0.1970.2060.216
TAF 25mg q.d.0.1710.2120.271
TAF 25mg q.d. w/COBI or RTV Boosting0.1810.2570.283
TFV 300mg q.d.1.92.43.0
TFV/ATV/RTV Arm 1: 300/300/100mg q.d.14.528.839.6
TFV/ATV/RTV Arm 2: 300/300/100mg q.d. Then 300/400/100mg q.d Then 300/300/100mg q.d.26.237.758.7

PK Parameter: Area Under the Curve From 0 to 24 Hours (AUC24) With Median (Range) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. AUC24h (area-under-the-curve from 0 to 24 hours) were determined using the trapezoidal rule. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm. Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8, 12 and 24 hours post dosing.

Interventionmg*hour/L (Median)
3rd TrimesterPostpartum
EFV 600mg q.d.55.458.3

PK Parameter: Area Under the Curve From 0 to 24 Hours (AUC24) With Median (Range) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. AUC24h (area-under-the-curve from 0 to 24 hours) were determined using the trapezoidal rule. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm. Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8, 12 and 24 hours post dosing.

Interventionmg*hour/L (Median)
2nd Trimester3rd TrimesterPostpartum
RPV 25mg q.d.1.9691.6692.387

PK Parameter: Maximum Concentration (Cmax) in mg/L With Median (IQR) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. Cmax was the maximum observed concentration after a dose. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm; Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8,12 (and 24) hours post dosing.

Interventionmg/L (Median)
3rd TrimesterPostpartum
EFV 600mg q.d.5.445.10

PK Parameter: Maximum Concentration (Cmax) in mg/L With Median (IQR) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. Cmax was the maximum observed concentration after a dose. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm; Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8,12 (and 24) hours post dosing.

,,,,,,,,,,,,,,
Interventionmg/L (Median)
2nd Trimester3rd TrimesterPostpartum
ATV/COBI 300/150 mg q.d.2.822.203.90
ATV/RTV Arm 1: 300/100mg q.d.NA3.64.1
ATV/RTV Arm 2: 300/100mg q.d. Then 400/100mg q.d. Then 300/100mg q.d.3.114.514.52
DRV/COBI 800/150 mg q.d.4.593.677.04
DRV/RTV 600 or 800 or 900/100mg b.i.d. Then 800 or 900/100mg b.i.d. Then 600/100mg b.i.d.6.226.558.96
DRV/RTV 600/100mg b.i.d.5.645.537.78
DRV/RTV 800/100mg q.d.6.775.788.11
DTG 50mg q.d.3.623.544.85
EFV 600 mg q.d. (Outside THA)3.875.134.41
FPV/RTV 700/100mg b.i.d.5.615.126.75
IDV/RTV Arm 2: 400/100mg q.d. (Only THA)3.893.625.37
NFV Arm 2: 1250mg b.i.d. Then 1875mg b.i.d. Then 1250mg b.i.d.NA5.15.0
TFV 300mg q.d.0.2500.2450.298
TFV/ATV/RTV Arm 1: 300/300/100mg q.d.1.22.54.1
TFV/ATV/RTV Arm 2: 300/300/100mg q.d. Then 300/400/100mg q.d Then 300/300/100mg q.d.2.733.565.43

PK Parameter: Maximum Concentration (Cmax) in mg/L With Median (Range) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. Cmax was the maximum observed concentration after a dose. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm; Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8,12 (and 24) hours post dosing.

,,,
Interventionmg/L (Median)
2nd Trimester3rd TrimesterPostpartum
ETR 200mg b.i.d.0.701.010.63
LPV/RTV Arm 3: 400/100mg b.i.d. Then 600/150mg b.i.d. Then 400/100mg b.i.d.8.410.714.6
RAL 400mg b.i.d.2.2501.7703.035
RPV 25mg q.d.0.1450.1340.134

PK Parameter: Maximum Concentration (Cmax) in ng/mL With Median (95% CI) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. Cmax was the maximum observed concentration after a dose. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm; Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8,12 (and 24) hours post dosing.

Interventionng/mL (Median)
3rd TrimesterPostpartum
MVC 150 or 300mg b.i.d.448647

PK Parameter: Maximum Concentration (Cmax) in ng/mL With Median (IQR) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. Cmax was the maximum observed concentration after a dose. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm; Blood samples were drawn pre-dose and at 1, 2, 4, 6, 8,12 (and 24) hours post dosing.

,,,
Interventionng/mL (Median)
2nd Trimester3rd TrimesterPostpartum
EVG/COBI 150/150mg q.d.1447.11432.81713.1
TAF 10mg q.d. w/COBI80.491.298.2
TAF 25mg q.d.69.796133
TAF 25mg q.d. w/COBI or RTV Boosting87.8107141

PK Parameter: Trough Concentration (C12) With Geometric Mean (95% CI) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. Trough concentration was the measured concentration from the 12h post-dose sample after an observed dose. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm. Trough concentration was measured 12 hrs after an observed dose.

Interventionng/mL (Geometric Mean)
3rd TrimesterPostpartum
MVC 150 or 300mg b.i.d.108128

PK Parameter: Trough Concentration (C12) With Median (IQR) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. Trough concentration was the measured concentration from the 12h post-dose sample after an observed dose. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation); 3rd trimester (30-38 gestation); and either 2-3 wks, 2-8 wks, or 6-12 wks postpartum, depending on study arm. Trough concentration was measured 12 hrs after an observed dose.

,,,
Interventionmg/L (Median)
2nd Trimester3rd TrimesterPostpartum
DRV/RTV 600 or 800 or 900/100mg b.i.d. Then 800 or 900/100mg b.i.d. Then 600/100mg b.i.d.2.842.524.51
DRV/RTV 600/100mg b.i.d.2.122.222.51
FPV/RTV 700/100mg b.i.d.2.121.642.87
NFV Arm 2: 1250mg b.i.d. Then 1875mg b.i.d. Then 1250mg b.i.d.NA0.470.52

PK Parameter: Trough Concentration (C12) With Median (Range) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. Trough concentration was the measured concentration from the 12h post-dose sample after an observed dose. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation); 3rd trimester (30-38 gestation); and either 2-3 wks, 2-8 wks, or 6-12 wks postpartum, depending on study arm. Trough concentration was measured 12 hrs after an observed dose.

,,,
Interventionmg/L (Median)
2nd Trimester3rd TrimesterPostpartum
ETR 200mg b.i.d.0.360.480.38
IDV/RTV Arm 2: 400/100mg q.d. (Only THA)0.130.130.28
LPV/RTV Arm 3: 400/100mg b.i.d. Then 600/150mg b.i.d. Then 400/100mg b.i.d.3.75.17.2
RAL 400mg b.i.d.0.06210.0640.0797

PK Parameter: Trough Concentration (C24) With Median (IQR) for ARVs and TB Drugs

"Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. Trough concentration was the measured concentration from the 24h post-dose sample after an observed dose.~For the TAF 25 mg q.d., 10 mg q.d. w/COBI, and 25 mg q.d. w/COBI or RTV boosting arms, samples were all below the limit of quantification and statistical analyses were not conducted." (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm. Trough concentration was measured 24 hrs after an observed dose.

,,,,,,,,,,,,,
Interventionmg/L (Median)
2nd Trimester3rd TrimesterPostpartum
ATV/COBI 300/150 mg q.d.0.210.210.61
ATV/RTV Arm 1: 300/100mg q.d.2.00.71.2
ATV/RTV Arm 2: 300/100mg q.d. Then 400/100mg q.d. Then 300/100mg q.d.0.490.710.90
DRV/COBI 800/150 mg q.d.0.330.271.43
DRV/RTV 800/100mg q.d.0.991.172.78
DTG 50mg q.d.0.730.931.28
EFV 600 mg q.d. (Outside THA)1.491.481.94
EVG/COBI 150/150mg q.d.0.02580.04870.3771
TAF 10mg q.d. w/COBI0.001950.001950.00195
TAF 25mg q.d.0.001950.001950.00195
TAF 25mg q.d. w/COBI or RTV Boosting0.001950.001950.00195
TFV 300mg q.d.0.0390.0540.061
TFV/ATV/RTV Arm 1: 300/300/100mg q.d.0.30.50.8
TFV/ATV/RTV Arm 2: 300/300/100mg q.d. Then 300/400/100mg q.d Then 300/300/100mg q.d.0.440.571.26

PK Parameter: Trough Concentration (C24) With Median (Range) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. Trough concentration was the measured concentration from the 24h post-dose sample after an observed dose. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm. Trough concentration was measured 24 hrs after an observed dose.

Interventionmg/L (Median)
3rd TrimesterPostpartum
EFV 600mg q.d.1.602.05

PK Parameter: Trough Concentration (C24) With Median (Range) for ARVs and TB Drugs

Pharmacokinetic parameters were determined from plasma concentration-time profiles using noncompartmental methods. Trough concentration was the measured concentration from the 24h post-dose sample after an observed dose. (NCT00042289)
Timeframe: Measured at 2nd trimester (20-26 wks gestation), 3rd trimester (30-38 wks gestation), and either 2-3 wks, 2-8 wks or 6-12 wks postpartum depending on study arm. Trough concentration was measured 24 hrs after an observed dose.

Interventionmg/L (Median)
2nd Trimester3rd TrimesterPostpartum
RPV 25mg q.d.0.0630.0560.081

Change in Maternal Weight Antepartum

Change in maternal antepartum weight per week based on generalized estimating equations (NCT03048422)
Timeframe: Baseline through before delivery (up to one day prior)

Interventionkg/week (Mean)
Arm 1: Maternal DTG+FTC/TAF0.378
Arm 2: Maternal DTG+FTC/TDF0.319
Arm 3: Maternal EFV/FTC/TDF0.291

Change in Maternal Weight Overall

Change in maternal weight per week based on generalized estimating equations (NCT03048422)
Timeframe: Baseline to 50 weeks postpartum

Interventionkg/week (Mean)
Arm 1: Maternal DTG+FTC/TAF-0.027
Arm 2: Maternal DTG+FTC/TDF-0.050
Arm 3: Maternal EFV/FTC/TDF-0.084

Change in Maternal Weight Postpartum

Change in maternal postpartum weight per week based on generalized estimating equations (NCT03048422)
Timeframe: Delivery to 50 weeks postpartum

Interventionkg/week (Mean)
Arm 1: Maternal DTG+FTC/TAF0.014
Arm 2: Maternal DTG+FTC/TDF-0.008
Arm 3: Maternal EFV/FTC/TDF-0.032

Count of Infants With HIV-1 Antiretroviral Drug Resistance Mutations at the Time of Infant HIV Diagnosis

Count of infants with HIV-1 antiretroviral drug resistance mutations (to any antiretroviral drug) at the time of infant HIV diagnosis, based on laboratory blood test results. (NCT03048422)
Timeframe: From birth through 50 weeks postpartum

InterventionParticipants (Count of Participants)
Arm 1 Infants1
Arm 2 Infants0
Arm 3 Infants1

Cumulative Probability of Infant Deaths

The Kaplan-Meier estimate of the cumulative probability of infant deaths from birth through 50 weeks after birth. (NCT03048422)
Timeframe: Birth through 50 weeks after birth

InterventionCumulative probability per 100 persons (Number)
Arm 1 Infants1.0
Arm 2 Infants2.0
Arm 3 Infants6.9

Cumulative Probability of Infant HIV-infection

The Kaplan-Meier estimate of the cumulative probability of infants acquiring HIV-1 infection from birth through 50 weeks after birth based on nucleic acid test results. (NCT03048422)
Timeframe: Birth through 50 weeks after birth

InterventionCumulative probability per 100 persons (Number)
Arm 1 Infants0.98
Arm 2 Infants0.50
Arm 3 Infants0.55

Cumulative Probability of Infants Experiencing Grade 3 or Higher Adverse Event

The Kaplan-Meier estimate of the cumulative probability of infants experiencing grade 3 or higher adverse events, including events resulting in death due to any cause. (NCT03048422)
Timeframe: Birth through Week 50 postpartum

InterventionCumulative probability per 100 persons (Number)
Arms 1 and 2 Infants26.8
Arm 3 Infants30.9

Cumulative Probability of Infants Experiencing Grade 3 or Higher Adverse Event

The Kaplan-Meier estimate of the cumulative probability of infants experiencing grade 3 or higher adverse events, including events resulting in death due to any cause. (NCT03048422)
Timeframe: From birth through Week 50 postpartum

InterventionCumulative probability per 100 persons (Number)
Arm 1 Infants25.3
Arm 2 Infants28.6
Arm 3 Infants30.9

Cumulative Probability of Women Experiencing Grade 3 or Higher Adverse Event

"The Kaplan-Meier estimate of the cumulative probability of women experiencing grade 3 or higher adverse events, including events resulting in death due to any cause.~Time to first maternal grade 3 or higher adverse event was defined as the first grade 3 or higher adverse event that occurred after randomization and before 74 weeks of follow-up. The timeframe of 74 weeks was determined by adding up 56 weeks of postpartum follow-up to the mean duration of antepartum follow-up, which was 18 weeks." (NCT03048422)
Timeframe: From randomization up to 74 weeks

,
InterventionCumulative probability per 100 persons (Number)
Arm 1: Maternal DTG+FTC/TAF25.1
Arm 2: Maternal DTG+FTC/TDF30.8
Arm 3: Maternal EFV/FTC/TDF27.9
Arms 1 and 2: Maternal DTG+FTC/TAF and DTG+FTC/TDF27.9
Arm 3: Maternal EFV/FTC/TDF27.9

Maternal Change in Creatinine Clearance

Maternal change in creatinine clearance per week based on generalized estimating equations (NCT03048422)
Timeframe: Baseline to 50 weeks postpartum

InterventionmL/min (Mean)
Arm 1: Maternal DTG+FTC/TAF-0.980
Arm 2: Maternal DTG+FTC/TDF-0.887
Arm 3: Maternal EFV/FTC/TDF-0.935

Percentage of Infants Born Small for Gestational Age

Percentage of infants born small for gestational age (<10th percentile adjusted for sex assigned at birth) based on Intergrowth 21st Standards (NCT03048422)
Timeframe: Birth

Interventionpercentage of participants (Number)
Arm 1 Infants16.3
Arm 2 Infants22.5
Arm 3 Infants20.5

Percentage of Mother-infant Pairs With an Adverse Pregnancy Outcome

Percentage of mother-infant pairs with an adverse pregnancy outcome. Adverse pregnancy outcome includes spontaneous abortion (<20 weeks gestation), stillbirth (≥20 weeks gestation), preterm delivery (<37 completed weeks), or small for gestational age (<10th percentile by INTERGROWTH 21st Standards) (NCT03048422)
Timeframe: Delivery

Interventionpercentage of mother-infant pairs (Number)
Arm 1: Maternal DTG+FTC/TAF24.1
Arm 2: Maternal DTG+FTC/TDF32.9
Arm 3: Maternal EFV/FTC/TDF32.7

Percentage of Mother-Infant Pairs With an Adverse Pregnancy Outcome

Percentage of mother-infant pairs with an adverse pregnancy outcome. Adverse pregnancy outcome includes spontaneous abortion (<20 weeks gestation), stillbirth (≥20 weeks gestation), preterm delivery (<37 completed weeks), or small for gestational age (<10th percentile per INTERGROWTH 21st Standards) (NCT03048422)
Timeframe: Delivery

Interventionpercentage of mother-infant pairs (Number)
Arms 1 and 2: Maternal DTG+FTC/TAF and DTG+FTC/TDF28.4
Arm 3: Maternal EFV/FTC/TDF32.7

Percentage of Mother-infant Pairs With an Adverse Pregnancy Outcome or Major Congenital Anomaly

Percentage of mother-infant pairs with an adverse pregnancy outcome or major congenital anomaly. Adverse pregnancy outcomes include spontaneous abortions (<20 weeks gestation), stillbirths (≥20 weeks gestation), preterm deliveries (<37 weeks gestation), and infants small for gestational age (<10th percentile per INTERGROWTH 21st Standards). Major congenital anomaly was defined consistent with the definition of malformation provided by Holmes and Westgate (i.e., a structural abnormality with surgical, medical, or cosmetic importance) and evaluated by an internal study team blinded to treatment arm. (NCT03048422)
Timeframe: Delivery through 50 weeks postpartum

Interventionpercentage of mother-infant pairs (Number)
Arm 1: Maternal DTG+FTC/TAF24.1
Arm 2: Maternal DTG+FTC/TDF32.9
Arm 3: Maternal EFV/FTC/TDF33.2

Percentage of Mother-Infant Pairs With Preterm Deliveries

Percentage of mother-infant pairs with preterm deliveries (<37 weeks gestation) resulting in live born infant (NCT03048422)
Timeframe: Delivery

Interventionpercentage of participants (Number)
Arm 1: Maternal DTG+FTC/TAF5.8
Arm 2: Maternal DTG+FTC/TDF9.4
Arm 3: Maternal EFV/FTC/TDF12.1

Percentage of Mothers With HIV-1 ARV Drug Resistance Mutations at the Time of Maternal Virologic Failure

Percentage of mothers with HIV-1 antiretroviral (ARV) drug resistance mutations at the time of maternal virologic failure. Virologic failure was defined as two consecutive plasma HIV-1 RNA viral loads <200 copies/mL on or after 24 weeks on study. Drug resistance mutations were assessed using the Stanford algorithm, and all ARV regimens were assessed for mutations. (NCT03048422)
Timeframe: From 24 weeks after randomization through Week 50 postpartum

Interventionpercentage of participants (Number)
Arm 1: Maternal DTG+FTC/TAF0.92
Arm 2: Maternal DTG+FTC/TDF1.86
Arm 3: Maternal EFV/FTC/TDF6.16

Percentage of Mothers With HIV-1 RNA Less Than 200 Copies/mL at 50 Weeks Postpartum

Percentage of mothers with HIV-1 RNA less than 200 copies/mL at 50 weeks postpartum using real-time test results obtained from site laboratories (NCT03048422)
Timeframe: 50 weeks postpartum

Interventionpercentage of participants (Number)
Arms 1 and 2: Maternal DTG+FTC/TAF and DTG+FTC/TDF96.3
Arm 3: Maternal EFV/FTC/TDF96.4

Percentage of Mothers With HIV-1 RNA Less Than 50 Copies/mL at Delivery Measured at Central Laboratory

Percentage of mothers with HIV-1 RNA less than 50 copies/mL at delivery using batched test results obtained from central laboratory (NCT03048422)
Timeframe: Delivery

Interventionpercentage of participants (Number)
Arms 1 and 2: Maternal DTG+FTC/TAF and DTG+FTC/TDF94.4
Arm 3: Maternal EFV/FTC/TDF78.8

Percentage of Mothers With Virologic Success of HIV-1 RNA Less Than 200 Copies/mL at 50 Weeks Postpartum Based on FDA Snapshot Algorithm

Percentage of mothers with virologic success of HIV-1 RNA less than 200 copies/mL at 50 weeks postpartum based on FDA snapshot algorithm using real-time test results obtained from site laboratories (NCT03048422)
Timeframe: 50 weeks postpartum

Interventionpercentage of participants (Number)
Arm 1: Maternal DTG+FTC/TAF75.6
Arm 2: Maternal DTG+FTC/TDF77.7
Arm 3: Maternal EFV/FTC/TDF76.3

Percentage of Mothers With Virologic Success of HIV-1 RNA Less Than 200 Copies/mL at Delivery Based on FDA Snapshot Algorithm

Percentage of mothers with virologic success of HIV-1 RNA less than 200 copies/mL at delivery based on FDA snapshot algorithm using real-time test results obtained from site laboratories (NCT03048422)
Timeframe: Delivery

Interventionpercentage of participants (Number)
Arm 1: Maternal DTG+FTC/TAF88.9
Arm 2: Maternal DTG+FTC/TDF92.6
Arm 3: Maternal EFV/FTC/TDF81.0

Time to First HIV-1 RNA Less Than 200 Copies/mL Through Delivery

Time to first viral HIV-1 RNA less than 200 copies/mL through delivery, determined using real-time results obtained from site laboratories (NCT03048422)
Timeframe: Randomization to delivery

Interventionweeks (Mean)
Arms 1 and 2: Maternal DTG+FTC/TAF and DTG+FTC/TDF4.26
Arm 3: Maternal EFV/FTC/TDF6.49

Infant Creatinine Clearance

Infant creatinine clearance based on Schwartz formula (NCT03048422)
Timeframe: Delivery and 26 weeks postpartum

,,
InterventionmL/min (Mean)
Delivery26 Weeks Postpartum
Arm 1 Infants52.7134.8
Arm 2 Infants53.1123.6
Arm 3 Infants49.0135.0

Percentage of Mothers With HIV-1 RNA Viral Load Less Than 200 Copies/mL at Delivery

Percentage of mothers with plasma HIV-1 RNA viral load less than 200 copies/mL at delivery determined using real-time test results obtained at site laboratories. This outcome was evaluated in the non-inferiority (primary outcome) and superiority (secondary outcome) analyses. The intention-to-treat analysis included all randomized women who had viral load data available. The per-protocol analysis excluded women who modified randomized treatment (stopped, paused, switched, added any treatment) before viral load evaluation at delivery, with the exception of women who modified randomized treatment for use of a concomitant medication. (NCT03048422)
Timeframe: Delivery

,
InterventionPercentage of participants (Number)
Intention-to-Treat AnalysisPer-Protocol Analysis
Arm 3: Maternal EFV/FTC/TDF91.091.4
Arms 1 and 2: Maternal DTG+FTC/TAF and DTG+FTC/TDF97.597.5

Reviews

20 reviews available for alanine and Pregnancy

ArticleYear
Tenofovir alafenamide use in pregnant and lactating women living with HIV.
    Expert opinion on drug metabolism & toxicology, 2020, Volume: 16, Issue:4

    Topics: Adenine; Alanine; Anti-HIV Agents; Female; HIV Infections; Humans; Lactation; Pregnancy; Pregnancy C

2020
Safety profile of the antiviral drug remdesivir: An update.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 130

    Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Female; Humans;

2020
New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19.
    Antimicrobial agents and chemotherapy, 2020, 12-16, Volume: 65, Issue:1

    Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Breast Feeding; Clinical Trials as Topi

2020
[Pharmacovigilance update].
    Revue medicale suisse, 2021, Jan-13, Volume: 17, Issue:720-1

    Topics: Adenosine Monophosphate; Alanine; Cleft Lip; Contraindications, Drug; COVID-19 Drug Treatment; Cytok

2021
The predicted risk of adverse pregnancy outcomes as a result of treatment-associated obesity in a hypothetical population receiving tenofovir alafenamide/emtricitabine/dolutegravir, tenofovir disoproxil fumarate/emtricitabine/dolutegravir or tenofovir dis
    AIDS (London, England), 2021, 12-15, Volume: 35, Issue:Suppl 2

    Topics: Alanine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Emtricitabine; Female; Heterocyclic

2021
A review of remdesivir for COVID-19 in pregnancy and lactation.
    The Journal of antimicrobial chemotherapy, 2021, 12-24, Volume: 77, Issue:1

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Breast Feeding; COVID-19 Drug Treatment; Female;

2021
Tenofovir alafenamide as compared to tenofovir disoproxil fumarate in the management of chronic hepatitis B with recent trends in patient demographics.
    Expert review of gastroenterology & hepatology, 2017, Volume: 11, Issue:11

    Topics: Adenine; Age Factors; Alanine; Antiviral Agents; Bone Density; Clinical Decision-Making; Female; Glo

2017
KIFC1: a promising chemotherapy target for cancer treatment?
    Oncotarget, 2016, Jul-26, Volume: 7, Issue:30

    Topics: Alanine; Antineoplastic Agents; Centrosome; DNA; Female; Humans; Kinesins; Mitosis; Molecular Target

2016
Biosynthesis of gonadotropin releasing hormone (GnRH): present status.
    Psychoneuroendocrinology, 1983, Volume: 8, Issue:3

    Topics: Alanine; Animals; Estrus; Female; Glycine; Hybridization, Genetic; Hypothalamus; Molecular Weight; O

1983
Hormonal regulation of protein degradation in skeletal and cardiac muscle.
    Life sciences, 1981, Jun-08, Volume: 28, Issue:23

    Topics: Adrenalectomy; Alanine; Animals; Corticosterone; Diabetes Mellitus, Experimental; Epinephrine; Fasti

1981
Nutrition in pregnancy.
    Postgraduate medical journal, 1979, Volume: 55, Issue:643

    Topics: Alanine; Blood Glucose; Body Weight; Diet; Energy Metabolism; Female; Fetal Growth Retardation; Huma

1979
The development and function of the endocrine pancreas of fetuses and infants born to normal and diabetic mothers.
    Acta endocrinologica. Supplementum, 1986, Volume: 277

    Topics: Alanine; Arginine; Blood Glucose; Female; Glucagon; Humans; Infant, Newborn; Infant, Premature; Infa

1986
Maternal factors modulating nutrient transfer to fetus.
    Biology of the neonate, 1987, Volume: 51, Issue:2

    Topics: Alanine; Animals; Blood Glucose; Female; Glycerol; Maternal-Fetal Exchange; Placenta; Pregnancy; Pre

1987
Etiology and pathophysiology of gestational diabetes mellitus.
    Diabetes, 1985, Volume: 34 Suppl 2

    Topics: Alanine; Amino Acids; Blood Glucose; Dietary Proteins; Female; Glucagon; Glucose Tolerance Test; Hum

1985
On the development of amino acid transport systems.
    Federation proceedings, 1973, Volume: 32, Issue:1

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Animals, Newborn; Arginine; Binding Sites; Bio

1973
The glucose-alanine cycle.
    Metabolism: clinical and experimental, 1973, Volume: 22, Issue:2

    Topics: Alanine; Amino Acids; Diabetes Mellitus; Female; Glucagon; Glucocorticoids; Gluconeogenesis; Glucose

1973
Starvation in pregnancy: metabolic changes.
    Nutrition reviews, 1973, Volume: 31, Issue:3

    Topics: Abortion, Therapeutic; Acidosis; Alanine; Amino Acids; Amniocentesis; Amniotic Fluid; Blood; Blood G

1973
Biochemistry of hypogylcin.
    FEBS letters, 1974, Mar-23, Volume: 40, Issue:0

    Topics: Alanine; Amino Acyl-tRNA Synthetases; Animals; Carbon Radioisotopes; Crystallization; Cyclopropanes;

1974
Metabolic adaptation to pregnancy.
    Nutrition reviews, 1974, Volume: 32, Issue:9

    Topics: Abortion, Induced; Alanine; Amniotic Fluid; Blood Glucose; Fatty Acids, Nonesterified; Female; Fetus

1974
[New etiologic approach to periodic ketoacidosis in children].
    Canadian Medical Association journal, 1971, Aug-07, Volume: 105, Issue:3

    Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Butyrates; Carbohydrate Metabolism, Inborn Errors; Ch

1971

Trials

5 trials available for alanine and Pregnancy

ArticleYear
Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2
    Lancet (London, England), 2021, 04-03, Volume: 397, Issue:10281

    Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Drug Therapy, Combination; Emtricitabine; Female; Gestatio

2021
Efficacy and safety of tenofovir disoproxil fumarate and tenofovir alafenamide fumarate in preventing HBV vertical transmission of high maternal viral load.
    Hepatology international, 2021, Volume: 15, Issue:5

    Topics: Alanine; Antiviral Agents; Female; Fumarates; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infan

2021
Evaluation of adalimumab effects in managing severe cases of COVID-19: A randomized controlled trial.
    International immunopharmacology, 2021, Volume: 99

    Topics: Adalimumab; Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; COVID-19 Drug Treatment

2021
Prenatal Maternal Stress from a Natural Disaster Alters Urinary Metabolomic Profiles in Project Ice Storm Participants.
    Scientific reports, 2018, 08-28, Volume: 8, Issue:1

    Topics: Adolescent; Alanine; Biomarkers; Cold Temperature; Energy Metabolism; Female; Humans; Ketone Bodies;

2018
Management of the pregnant diabetic: home or hospital, with or without glucose meters?
    Lancet (London, England), 1980, May-24, Volume: 1, Issue:8178

    Topics: Adolescent; Adult; Alanine; Blood Glucose; Blood Specimen Collection; Diabetes Mellitus; Evaluation

1980

Other Studies

319 other studies available for alanine and Pregnancy

ArticleYear
Antiviral effects of human placenta hydrolysate (Laennec
    Journal of microbiology (Seoul, Korea), 2021, Volume: 59, Issue:11

    Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chlorocebus aethiops; COVID-19 Drug Tre

2021
Tenofovir Alafenamide Plasma Concentrations Are Reduced in Pregnant Women Living With Human Immunodeficiency Virus (HIV): Data From the PANNA Network.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022, 09-10, Volume: 75, Issue:4

    Topics: Adenine; Alanine; Anti-HIV Agents; Female; HIV; HIV Infections; Humans; Pregnancy; Pregnant Women; T

2022
COVID-19 Therapeutics for Nonhospitalized Patients.
    JAMA, 2022, 02-15, Volume: 327, Issue:7

    Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiv

2022
Early Administration of Remdesivir and Intensive Care Unit Admission in Hospitalized Pregnant Individuals With Coronavirus Disease 2019 (COVID-19).
    Obstetrics and gynecology, 2022, 04-01, Volume: 139, Issue:4

    Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Female; Hospitalization; Humans; Intensiv

2022
Pharmacokinetics of Tenofovir Alafenamide With Boosted Protease Inhibitors in Pregnant and Postpartum Women Living With HIV: Results From IMPAACT P1026s.
    Journal of acquired immune deficiency syndromes (1999), 2022, 07-01, Volume: 90, Issue:3

    Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Antiviral Agents; Female; HIV Infections; Humans; Postpart

2022
Effects of maternal branched-chain amino acid and alanine supplementation on growth and biomarkers of protein metabolism in dams fed a low-protein diet and their offspring.
    Amino acids, 2022, Volume: 54, Issue:7

    Topics: Alanine; Amino Acids, Branched-Chain; Animals; Biomarkers; Body Weight; Caseins; Diet, High-Fat; Die

2022
Plasma and breast milk pharmacokinetics of tenofovir alafenamide in mothers with chronic hepatitis B infection.
    Alimentary pharmacology & therapeutics, 2022, Volume: 56, Issue:3

    Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Female; Hepatitis B; Hepatitis B, Chronic; HIV Infections;

2022
Remdesivir impairs mouse preimplantation embryo development at therapeutic concentrations.
    Reproductive toxicology (Elmsford, N.Y.), 2022, Volume: 111

    Topics: Adenosine Monophosphate; Alanine; Animals; Blastocyst; COVID-19 Drug Treatment; Embryonic Developmen

2022
Screening models combining maternal characteristics and multiple markers for the early prediction of preeclampsia in pregnancy: a nested case-control study.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2022, Volume: 42, Issue:6

    Topics: 5'-Nucleotidase; Alanine; alpha-L-Fucosidase; Aspartate Aminotransferases; Biomarkers; Case-Control

2022
HBV in pregnancy: time to consider tenofovir alafenamide (TAF).
    Hepatology international, 2022, Volume: 16, Issue:4

    Topics: Adenine; Alanine; Female; Hepatitis B virus; HIV Infections; Humans; Pregnancy; Tenofovir

2022
Tenofovir Alafenamide use in pregnant women with chronic hepatitis B virus infection: more data needed.
    Hepatology international, 2022, Volume: 16, Issue:4

    Topics: Adenine; Alanine; Antiviral Agents; Female; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Hu

2022
Resveratrol modulates the gut microbiota of cholestasis in pregnant rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2022, Volume: 73, Issue:2

    Topics: Alanine; Alanine Transaminase; Animals; Aspartic Acid; Bile Acids and Salts; Cholestasis; Cholestasi

2022
Plasma Amino Acids in Early Pregnancy and Midpregnancy and Their Interplay With Phospholipid Fatty Acids in Association With the Risk of Gestational Diabetes Mellitus: Results From a Longitudinal Prospective Cohort.
    Diabetes care, 2023, 04-01, Volume: 46, Issue:4

    Topics: Alanine; Amines; Amino Acids; Aspartic Acid; Diabetes, Gestational; Fatty Acids; Female; Glutamates;

2023
Magnetic resonance spectroscopy and liquid chromatography-mass spectrometry metabolomics study may differentiate pre-eclampsia from gestational hypertension.
    European radiology, 2023, Volume: 33, Issue:7

    Topics: Alanine; Creatine; Female; Glutamic Acid; Humans; Hypertension, Pregnancy-Induced; Magnetic Resonanc

2023
Untargeted metabolomics and lipidomics to assess plasma metabolite changes in dairy goats with subclinical hyperketonemia.
    Journal of dairy science, 2023, Volume: 106, Issue:5

    Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Fatty Acids, Nonesterified; Female; Goat Diseases; Goats; K

2023
Discrimination of blood metabolomics profiles in neonates with idiopathic polyhydramnios.
    European journal of pediatrics, 2023, Volume: 182, Issue:11

    Topics: Alanine; Asparagine; Aspartic Acid; Cesarean Section; Child; Chromatography, Liquid; Female; Glutama

2023
Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring.
    Chemosphere, 2023, Volume: 341

    Topics: Alanine; Animals; Aspartic Acid; Cytochrome P-450 Enzyme System; Female; Gene Expression Profiling;

2023
[Analysis of the difference in metabolites and gene expressions between pre-receptive and receptive endometria].
    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2023, Dec-10, Volume: 40, Issue:12

    Topics: Alanine; Amino Acids; Carnitine; Endometrium; Female; Gene Expression; Humans; Infertility, Female;

2023
Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2019, 11-01, Volume: 317, Issue:5

    Topics: Alanine; Amino Acids; Animals; Female; Fetal Growth Retardation; Fetus; Hindlimb; Lower Extremity; M

2019
Protect Pregnant and Lactating Women with COVID-19 Through Research, Not from Research.
    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2020, Volume: 15, Issue:6

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Breast Feeding; Coronavirus Inf

2020
Tocilizumab and Remdesivir in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19).
    Obstetrics and gynecology, 2020, Volume: 136, Issue:5

    Topics: Adenosine Monophosphate; Adult; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betaco

2020
Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming.
    American journal of obstetrics and gynecology, 2021, Volume: 224, Issue:2

    Topics: Adult; Alanine; Arginine; Carnitine; Case-Control Studies; Diabetes, Gestational; Diet Therapy; Dopa

2021
Use of remdesivir for pregnant patients with severe novel coronavirus disease 2019.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:5

    Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Coronavirus Infections; COVID-19; Female;

2020
Compassionate use of remdesivir for treatment of severe coronavirus disease 2019 in pregnant women at a United States academic center.
    American journal of obstetrics & gynecology MFM, 2020, Volume: 2, Issue:3

    Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Clinical Decision-Making; Compassionate U

2020
Preferential use of dexamethasone for fetal lung maturation in severe coronavirus disease 2019.
    American journal of obstetrics & gynecology MFM, 2020, Volume: 2, Issue:4

    Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Compassionate Use Trials; COVID-19; Dexam

2020
Efficacy and safety of tenofovir alafenamide fumarate for preventing mother-to-child transmission of hepatitis B virus: a national cohort study.
    Alimentary pharmacology & therapeutics, 2020, Volume: 52, Issue:8

    Topics: Abnormalities, Drug-Induced; Adenine; Adult; Alanine; Chemoprevention; China; Cohort Studies; DNA, V

2020
Compassionate Use of Remdesivir in Pregnant Women With Severe Coronavirus Disease 2019.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 12-06, Volume: 73, Issue:11

    Topics: Adenosine Monophosphate; Adult; Alanine; Compassionate Use Trials; COVID-19 Drug Treatment; Female;

2021
Pharmacokinetics of tenofovir alafenamide with and without cobicistat in pregnant and postpartum women living with HIV.
    AIDS (London, England), 2021, 03-01, Volume: 35, Issue:3

    Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Cobicistat; Emtricitabine; Female; HIV Infections; Humans;

2021
Risk of congenital birth defects during COVID-19 pandemic: Draw attention to the physicians and policymakers.
    Journal of global health, 2020, Volume: 10, Issue:2

    Topics: Adenosine Monophosphate; Alanine; Antimalarials; Antiviral Agents; Congenital Abnormalities; COVID-1

2020
Tenofovir Alafenamide to Prevent Perinatal Hepatitis B Transmission: A Multicenter, Prospective, Observational Study.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 11-02, Volume: 73, Issue:9

    Topics: Alanine; Antiviral Agents; Female; Hepatitis B; Hepatitis B, Chronic; Humans; Infant; Infant, Newbor

2021
Remdesivir (Veklury) for COVID-19.
    The Medical letter on drugs and therapeutics, 2020, 11-30, Volume: 62, Issue:1612

    Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19 Drug T

2020
Remdesivir for the treatment of COVID-19 in pregnancy.
    Journal of medical virology, 2021, Volume: 93, Issue:7

    Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Female; Humans;

2021
Assessing Exposome Effects on Pregnancy through Urine Metabolomics of a Portuguese (Estarreja) Cohort.
    Journal of proteome research, 2018, 03-02, Volume: 17, Issue:3

    Topics: Aconitic Acid; Adult; Air Pollutants; Alanine; Allantoin; Chemical Industry; Citric Acid; Cohort Stu

2018
A carnivore embryo's perspective on essential amino acids and ammonium in culture medium: effects on the development of feline embryos.
    Biology of reproduction, 2018, 11-01, Volume: 99, Issue:5

    Topics: Alanine; Amino Acids, Essential; Ammonium Compounds; Animals; Blastocyst; Cats; Culture Media; Dieta

2018
THE ROLE OF PRO12ALA POLYMORPHISM OF THE PPAR-Γ GENE IN THE GENESIS OF THE GESTATIONAL WEIGHT GAIN.
    Georgian medical news, 2018, Issue:285

    Topics: Alanine; Blood Glucose; Cholesterol; Female; Genotype; Gestational Weight Gain; Humans; Insulin; Pol

2018
Supplementation of sows with
    Meat science, 2019, Volume: 152

    Topics: Alanine; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Arginine; Birth Weight; D

2019
Recurrence of CCHS associated PHOX2B poly-alanine expansion mutation due to maternal mosaicism.
    Pediatric pulmonology, 2014, Volume: 49, Issue:3

    Topics: Abortion, Spontaneous; Alanine; Electrophoresis, Capillary; Female; Genetic Counseling; Germ-Line Mu

2014
The influence of maternal disease on metabolites measured as part of newborn screening.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:14

    Topics: Acetylcarnitine; Alanine; Biomarkers; Female; Fetal Blood; Humans; Infant, Newborn; Male; Multivaria

2013
Oxidative stress decreases uptake of neutral amino acids in a human placental cell line (BeWo cells).
    Reproductive toxicology (Elmsford, N.Y.), 2013, Volume: 40

    Topics: Alanine; Amino Acids, Neutral; Cell Line; Female; Humans; Oxidative Stress; Phosphatidylinositol 3-K

2013
Type 2 deiodinase Thr92Ala polymorphism is associated with disrupted placental activity but not with dysglycemia or adverse gestational outcomes: a genetic association study.
    Fertility and sterility, 2014, Volume: 101, Issue:3

    Topics: Adolescent; Adult; Alanine; Blood Glucose; Cross-Sectional Studies; Female; Genetic Association Stud

2014
Characterization of the serum metabolic profile of dairy cows with milk fever using 1H-NMR spectroscopy.
    The veterinary quarterly, 2014, Volume: 34, Issue:3

    Topics: Alanine; Analysis of Variance; Animals; Blood Glucose; Cattle; Cattle Diseases; Dairying; Female; Gl

2014
Adaptation of in vivo amino acid kinetics facilitates increased amino acid availability for fetal growth in adolescent and adult pregnancies alike.
    The British journal of nutrition, 2014, Dec-14, Volume: 112, Issue:11

    Topics: Adolescent; Adult; Alanine; Amino Acids; Blood Proteins; Female; Glutamine; Humans; Infant, Newborn;

2014
Incorporation of non-canonical amino acids into the developing murine proteome.
    Scientific reports, 2016, 08-30, Volume: 6

    Topics: Alanine; Alkynes; Amino Acids; Animals; Embryonic Development; Female; Glycine; Methionine; Mice; Pr

2016
First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease.
    The Journal of infectious diseases, 2017, Jan-15, Volume: 215, Issue:2

    Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal; Antiviral Agents; Blood; Female; Hemorrhag

2017
Over-expression of the potassium channel Kir2.3 using the dopamine-1 receptor promoter selectively inhibits striatal neurons.
    Neuroscience, 2008, Jul-31, Volume: 155, Issue:1

    Topics: Alanine; Analysis of Variance; Animals; Cnidarian Venoms; Corpus Striatum; Embryo, Mammalian; Female

2008
The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake.
    Brain research, 2008, Aug-28, Volume: 1227

    Topics: Alanine; Amino Acid Transport Systems, Neutral; Androstadienes; Animals; Biological Transport; Blott

2008
Dietary arginine supplementation during early pregnancy enhances embryonic survival in rats.
    The Journal of nutrition, 2008, Volume: 138, Issue:8

    Topics: Alanine; Amino Acids; Animals; Arginine; Diet; Dietary Supplements; Embryo Implantation; Embryo Loss

2008
Breast-feeding modifies the association of PPARgamma2 polymorphism Pro12Ala with growth in early life: the Generation R Study.
    Diabetes, 2009, Volume: 58, Issue:4

    Topics: Alanine; Amino Acid Substitution; Body Weight; Breast Feeding; Child; Diabetes Mellitus, Type 2; Fem

2009
Enterocin C, a class IIb bacteriocin produced by E. faecalis C901, a strain isolated from human colostrum.
    International journal of food microbiology, 2009, Jul-31, Volume: 133, Issue:1-2

    Topics: Alanine; Amino Acid Sequence; Anti-Infective Agents; Bacteriocin Plasmids; Bacteriocins; Base Sequen

2009
The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancy.
    Endocrinology, 2009, Volume: 150, Issue:9

    Topics: Alanine; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Down-Regulation; Female; Ge

2009
Imidazole-based erythrocyte markers of oxidative stress in preeclampsia--an NMR investigation.
    Reproductive sciences (Thousand Oaks, Calif.), 2009, Volume: 16, Issue:11

    Topics: Adult; Alanine; Biomarkers; Ergothioneine; Erythrocytes; Female; Histidine; Humans; Magnetic Resonan

2009
Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using (1)H HR-MAS spectroscopy.
    Magma (New York, N.Y.), 2009, Volume: 22, Issue:6

    Topics: Adult; Alanine; Amniotic Fluid; Betaine; Biomarkers; Citric Acid; Creatinine; Female; Glucose; Human

2009
Interaction of maternal peroxisome proliferator-activated receptor gamma2 Pro12Ala polymorphism with fetal sex affects maternal glycemic control during pregnancy.
    Pharmacogenetics and genomics, 2010, Volume: 20, Issue:2

    Topics: Adult; Alanine; Amino Acid Substitution; Blood Glucose; Female; Fetus; Genetic Predisposition to Dis

2010
Computational modelling of amino acid transfer interactions in the placenta.
    Experimental physiology, 2010, Volume: 95, Issue:7

    Topics: Alanine; Amino Acid Transport Systems; Amino Acids; Biological Transport; Computer Simulation; Femal

2010
Peroxisome proliferator-activated receptor gamma polymorphism and periodontitis in pregnant Japanese women.
    Journal of periodontology, 2010, Volume: 81, Issue:6

    Topics: Alanine; Amino Acid Substitution; Chi-Square Distribution; Dental Plaque; DNA Mutational Analysis; F

2010
Ala16Val SOD2 polymorphism is associated with higher pregnancy rates in in vitro fertilization cycles.
    Fertility and sterility, 2011, Volume: 95, Issue:5

    Topics: Adult; Alanine; Amino Acid Substitution; Base Sequence; Case-Control Studies; Female; Fertilization

2011
Dietary L-arginine supplementation enhances placental growth and reproductive performance in sows.
    Amino acids, 2012, Volume: 42, Issue:6

    Topics: Alanine; Amino Acids; Animal Feed; Animals; Arginine; Birth Weight; Dietary Supplements; Estradiol;

2012
First-trimester prediction of preeclampsia using metabolomic biomarkers: a discovery phase study.
    Prenatal diagnosis, 2011, Volume: 31, Issue:10

    Topics: Adult; Alanine; Area Under Curve; Biomarkers; Carnitine; Case-Control Studies; Female; Gestational A

2011
Influence of Val16Ala SOD2 polymorphism on the in-vitro effect of clomiphene citrate in oxidative metabolism.
    Reproductive biomedicine online, 2012, Volume: 24, Issue:4

    Topics: Adult; Alanine; Amino Acid Substitution; Cell Survival; Cells, Cultured; Clomiphene; Female; Fertili

2012
A brain aggregate model gives new insights into the pathobiology and treatment of prion diseases.
    Journal of neuropathology and experimental neurology, 2012, Volume: 71, Issue:5

    Topics: Alanine; Animals; Azepines; Brain; Cathepsin D; Dendrites; Disease Models, Animal; Embryo, Mammalian

2012
The IgG autoimmune response in postpartum acquired hemophilia A targets mainly the A1a1 domain of FVIII.
    Journal of thrombosis and haemostasis : JTH, 2012, Volume: 10, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Alanine; Factor VIII; Female; Hemophilia A; Humans; Immunoglobulin G

2012
Nicotine exposure during adolescence leads to short- and long-term changes in spike timing-dependent plasticity in rat prefrontal cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Aug-01, Volume: 32, Issue:31

    Topics: Action Potentials; Age Factors; Aging; Alanine; Amino Acids; Animals; Animals, Newborn; Bridged Bicy

2012
Are alanine, cysteine, glycine and valine amino acids the cause of non-immune hydrops fetalis?
    Clinical and experimental obstetrics & gynecology, 2012, Volume: 39, Issue:3

    Topics: Adult; Alanine; Amniocentesis; Amniotic Fluid; Cysteine; Female; Glycine; Humans; Hydrops Fetalis; P

2012
The role of amino acids in spina bifida.
    Clinical and experimental obstetrics & gynecology, 2012, Volume: 39, Issue:3

    Topics: Adult; Alanine; Amino Acids; Amniocentesis; Amniotic Fluid; Cystathionine; Cysteine; Female; Gestati

2012
Hb G Makassar (beta 6:Glu-Ala) in a Thai family.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2002, Volume: 85, Issue:5

    Topics: Adult; Alanine; Asian People; Chromatography, High Pressure Liquid; Female; Globins; Glutamic Acid;

2002
Effects of epidermal growth factor on placental amino acids uptake in pregnant rats.
    The Journal of veterinary medical science, 2002, Volume: 64, Issue:8

    Topics: Alanine; Amino Acids; Animals; Biological Transport, Active; Dose-Response Relationship, Drug; Embry

2002
Amino acid turnover by elongating cattle blastocysts recovered on days 14-16 after insemination.
    Reproduction (Cambridge, England), 2002, Volume: 124, Issue:5

    Topics: Alanine; Amino Acids; Animals; Arginine; Blastocyst; Cattle; Culture Techniques; Embryonic and Fetal

2002
Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia.
    Biochimica et biophysica acta, 2003, May-20, Volume: 1638, Issue:1

    Topics: Alanine; Amino Acid Transport System ASC; Base Sequence; Cell Fusion; Cell Hypoxia; Cell Line; Colfo

2003
Glutamine synthesis in the developing porcine placenta.
    Biology of reproduction, 2004, Volume: 70, Issue:5

    Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Alanine; Alanine Transaminase; Amino Acids; Amino

2004
Insulin action during late pregnancy in the conscious dog.
    American journal of physiology. Endocrinology and metabolism, 2004, Volume: 286, Issue:6

    Topics: Alanine; Amino Acids; Animals; Consciousness; Dogs; Fatty Acids, Nonesterified; Female; Gluconeogene

2004
Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene.
    Endocrinology, 2004, Volume: 145, Issue:7

    Topics: Alanine; Animals; Animals, Outbred Strains; DNA-Binding Proteins; Female; Forkhead Box Protein L2; F

2004
Hyperlactatemia in human immunodeficiency virus-uninfected infants who are exposed to antiretrovirals.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Alanine; Antiretroviral Therapy, Highly Active; Didanosine; Female; HIV Infections; HIV Seronegativi

2004
Are plasma total homocysteine and other amino acids associated with glucose intolerance in uncomplicated pregnancies and preeclampsia?
    European journal of obstetrics, gynecology, and reproductive biology, 2005, Mar-01, Volume: 119, Issue:1

    Topics: Adult; Alanine; Amino Acids; Diabetes, Gestational; Female; Glucose Intolerance; Homocysteine; Human

2005
The relationship between changes in serum glycine and alanine concentrations in non-essential amino acid and milk production in the transition period in dairy cows.
    The Journal of veterinary medical science, 2005, Volume: 67, Issue:2

    Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Cattle; Dairying; Female; Glycine; Lactation; P

2005
The recycling of carbon in glucose, lactate and alanine in sheep.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2005, Volume: 175, Issue:6

    Topics: Alanine; Animals; Blood Glucose; Carbon; Carbon Dioxide; Carbon Radioisotopes; Female; Glucose; Lact

2005
Is there a folate-related gene-environment interaction in the etiology of childhood acute lymphoblastic leukemia?
    International journal of cancer, 2006, Jul-01, Volume: 119, Issue:1

    Topics: Alanine; Bone Marrow; Child; Child, Preschool; Cysteine; Dietary Supplements; DNA, Neoplasm; Female;

2006
Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo).
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 291, Issue:3

    Topics: Alanine; Amino Acid Transport System A; Aminoisobutyric Acids; Biological Transport, Active; Cell Li

2006
The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on glucose/insulin metabolism interact with prenatal exposure to famine.
    Diabetes care, 2006, Volume: 29, Issue:5

    Topics: Aged; Alanine; Blood Glucose; DNA Primers; Female; Humans; Insulin; Male; Maternal Age; Netherlands;

2006
Hepatic and muscle insulin action during late pregnancy in the dog.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:1

    Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Dogs; Fatty Acids, Nonesterified; Female; Gl

2007
Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-11, Volume: 104, Issue:50

    Topics: Alanine; Alleles; Arginine; Arthritis, Rheumatoid; Aspartic Acid; Child; Cohort Studies; Epitopes; F

2007
Detection and identification of novel metabolomic biomarkers in preeclampsia.
    Reproductive sciences (Thousand Oaks, Calif.), 2008, Volume: 15, Issue:6

    Topics: Alanine; Biomarkers; Cohort Studies; Female; Glutamic Acid; Humans; Infant, Newborn; Ketoglutaric Ac

2008
Free amino acids of human foetal and adult liver.
    Nature, 1966, Oct-15, Volume: 212, Issue:5059

    Topics: Adult; Alanine; Amino Acids; Aspartic Acid; Autoanalysis; Cystine; Female; Fetus; Glutamates; Glycin

1966
"Accelerated starvation" and the skipped breakfast in late normal pregnancy.
    Lancet (London, England), 1982, Mar-13, Volume: 1, Issue:8272

    Topics: 3-Hydroxybutyric Acid; Alanine; Blood Glucose; Diabetes Mellitus; Fasting; Fatty Acids, Nonesterifie

1982
Influence of sarcosine or N-methylalanine in position 7 on the antagonistic properties of [1-deaminopenicillamine]- and [1-(beta-mercapto-beta, beta-cyclopentylmethylene-propionic acid)]-vasopressin.
    International journal of peptide and protein research, 1984, Volume: 23, Issue:1

    Topics: Alanine; Animals; Arginine Vasopressin; Biological Assay; Drug Antagonism; Female; Indicators and Re

1984
Prematurity in the rat. I. Fuels and gluconeogenic enzymes.
    Biology of the neonate, 1980, Volume: 37, Issue:1-2

    Topics: Alanine; Animals; Animals, Newborn; Blood Glucose; Energy Metabolism; Female; Fructose-Bisphosphatas

1980
[Studies on the amino acid transport systems in the human placenta--L-alanine and L-leucine uptake by microvillous brush border membrane vesicles].
    Nihon Sanka Fujinka Gakkai zasshi, 1983, Volume: 35, Issue:1

    Topics: Alanine; Alkaline Phosphatase; Biological Transport; Chorionic Villi; Female; Humans; Leucine; Nucle

1983
Effects of intravenous glycine infusion on plasma glucagon, insulin and metabolite concentrations in lambs before and after birth.
    Journal of developmental physiology, 1983, Volume: 5, Issue:1

    Topics: Alanine; Animals; Animals, Newborn; Female; Fetal Blood; Fetus; Glucagon; Glycine; Infusions, Parent

1983
Severe hypoglycemia and hyperinsulinemia in falciparum malaria.
    The New England journal of medicine, 1983, Jul-14, Volume: 309, Issue:2

    Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Alanine; Blood Glucose; Brain Diseases; C-Peptide; Child;

1983
Synthesis of a novel class of heteroaromatic amino acids and their use in the preparation of analogues of luteinizing hormone-releasing hormone.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:3

    Topics: Alanine; Animals; Benzothiazoles; Chemical Phenomena; Chemistry; Estrus; Female; Gonadotropin-Releas

1984
Insulin resistance of late pregnancy does not include the liver.
    Metabolism: clinical and experimental, 1984, Volume: 33, Issue:6

    Topics: Alanine; Animals; Binding Sites; Female; Glucose; Glucose Tolerance Test; In Vitro Techniques; Insul

1984
Effects of the taurine transport antagonist, guanidinoethane sulfonate, and beta-alanine on the morphology of rat retina.
    Journal of neuroscience research, 1983, Volume: 9, Issue:2

    Topics: Alanine; Animals; Animals, Newborn; beta-Alanine; Cats; Female; Microscopy, Electron; Pregnancy; Pre

1983
Oxidation of alanine and beta-hydroxybutyrate in late gestation by zinc-restricted rats.
    The Journal of nutrition, 1983, Volume: 113, Issue:9

    Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Carbon Dioxide; Diet; Female; Hydroxybutyrates; Oxidation-R

1983
The irreversible loss of alanine and of glycine in fetal and sucking lambs.
    The British journal of nutrition, 1984, Volume: 52, Issue:3

    Topics: Alanine; Animal Population Groups; Animals; Animals, Suckling; Carbon Dioxide; Female; Fetus; Glycin

1984
Hemoglobin A2 Fitzroy delta 142 Ala----Asp: a new delta-chain variant.
    Hemoglobin, 1984, Volume: 8, Issue:4

    Topics: Adult; Alanine; Amino Acid Sequence; Amino Acids; Aspartic Acid; Blood Protein Electrophoresis; Chro

1984
Glucose absorption by in vitro perfused colon of the fetal rat.
    The American journal of physiology, 1983, Volume: 245, Issue:3

    Topics: Alanine; Animals; Biological Transport; Colon; Female; Fetus; Glucose; Intestinal Absorption; Micros

1983
Purine de novo synthesis in liver and developing rat brain, and the effect of some inhibitors of purine nucleotide interconversion.
    Enzyme, 1983, Volume: 30, Issue:3

    Topics: Aging; Alanine; Allopurinol; Animals; Animals, Newborn; Anti-Bacterial Agents; Azaserine; Brain; Fem

1983
Metabolic consequences of fasting during Ramadan in pregnant and lactating women.
    Human nutrition. Clinical nutrition, 1983, Volume: 37, Issue:4

    Topics: 3-Hydroxybutyric Acid; Adult; Africa, Western; Alanine; Blood Glucose; Energy Metabolism; Fasting; F

1983
Fetal and maternal amino acid concentrations during fasting in the ewe.
    Journal of pediatric gastroenterology and nutrition, 1984, Volume: 3, Issue:2

    Topics: Alanine; Amino Acids; Animals; Blood Glucose; Fasting; Female; Fetal Blood; Gluconeogenesis; Materna

1984
[Amino acid transfer at the fetal surface of the trophoblast and the characterization of its carrier in the rat placenta in vivo].
    Nihon Sanka Fujinka Gakkai zasshi, 1984, Volume: 36, Issue:3

    Topics: Alanine; Amino Acids; Animals; Biological Transport; Female; Fetal Blood; Glucose; Maternal-Fetal Ex

1984
Inhibition of placental amino acid uptake in rats following acute and chronic ethanol exposure.
    Alcoholism, clinical and experimental research, 1982,Fall, Volume: 6, Issue:4

    Topics: Acetaldehyde; Alanine; Alcoholism; Amino Acids; Aminoisobutyric Acids; Animals; Betaine; Cycloleucin

1982
Method for the study of metabolite transfer from rat mother to fetus.
    Biology of the neonate, 1983, Volume: 44, Issue:2

    Topics: Alanine; Animals; Arteries; Carbon Radioisotopes; Female; Glucose; Jugular Veins; Maternal-Fetal Exc

1983
The utilization of lactic acid by sheep in late pregnancy.
    Quarterly journal of experimental physiology (Cambridge, England), 1981, Volume: 66, Issue:3

    Topics: Alanine; Animals; Blood Glucose; Female; Lactates; Muscles; Oxygen Consumption; Pregnancy; Pregnancy

1981
Alanine-stimulated insulin secretion in the fetal and neonatal lamb.
    American journal of obstetrics and gynecology, 1980, Mar-01, Volume: 136, Issue:5

    Topics: Alanine; Animals; Animals, Newborn; Female; Fetus; Glucose; Insulin; Insulin Secretion; Pregnancy; S

1980
Glucose kinetics in leprechaunism: accelerated fasting due to insulin resistance.
    The Journal of clinical endocrinology and metabolism, 1980, Volume: 51, Issue:5

    Topics: Abnormalities, Multiple; Alanine; Blood Glucose; Child, Preschool; Eating; Fasting; Female; Fetal Gr

1980
Pancreatic alpha cell response to alanine during and after normal and diabetic pregnancies.
    Obstetrics and gynecology, 1980, Volume: 56, Issue:4

    Topics: Administration, Oral; Adult; Alanine; Blood Glucose; Female; Glucagon; Humans; Insulin; Insulin Secr

1980
Effect of endogenous insulin release on fetal alanine concentration and uptake.
    American journal of obstetrics and gynecology, 1981, Volume: 139, Issue:1

    Topics: Alanine; Amino Acids; Animals; Blood Glucose; Female; Fetus; Insulin; Pregnancy; Sheep; Tolbutamide

1981
Effects of pregnancy and sex steroid administration on skeletal muscle metabolism in the rat.
    Diabetes, 1981, Volume: 30, Issue:7

    Topics: Alanine; Animals; Estradiol; Female; Glucose; Glycerol; Insulin; Lactates; Lactic Acid; Muscles; Oxy

1981
Diurnal variations in blood intermediary metabolites in mild gestational diabetic patients and the effect of a carbohydrate-restricted diet.
    Diabetologia, 1982, Volume: 22, Issue:2

    Topics: Alanine; Blood Glucose; Dietary Carbohydrates; Female; Glucose Tolerance Test; Humans; Ketone Bodies

1982
Transport specificity for neutral and basic amino acids at maternal and fetal interfaces of the guinea-pig placenta.
    The Journal of physiology, 1982, Volume: 328

    Topics: Alanine; Animals; Biological Transport; Female; Guinea Pigs; In Vitro Techniques; Kinetics; Maternal

1982
[Energy metabolism of newborn rats during the first hours of extrauterine life].
    Revista espanola de fisiologia, 1982, Volume: 38 Suppl

    Topics: Alanine; Animals; Animals, Newborn; Animals, Suckling; Blood Glucose; Energy Metabolism; Fatty Acids

1982
Utilization of alanine by hypothyroid and growth hormone treated hypothyroid rats, their fetuses and progeny.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1982, Volume: 14, Issue:12

    Topics: Alanine; Animals; Animals, Newborn; Female; Fetus; Gluconeogenesis; Growth Hormone; Hypothyroidism;

1982
Fasting glucose production in the smaller of twins with epinephrine-deficient hypoglycemia.
    Metabolism: clinical and experimental, 1981, Volume: 30, Issue:1

    Topics: Alanine; Amino Acids; Birth Weight; Blood Glucose; Child; Child, Preschool; Epinephrine; Fasting; Fe

1981
Metabolic response to starvation. I. Relative effects of pregnancy and sex steroid administration in the rat.
    Metabolism: clinical and experimental, 1981, Volume: 30, Issue:3

    Topics: Acetoacetates; Alanine; Animals; Estradiol; Fatty Acids, Nonesterified; Female; Hydroxybutyrates; Ke

1981
An improved technique for perfusion of the guinea pig placenta in situ giving viable conditions demonstrated by placental transport of amino acids (L- and D-alanine).
    Biology of the neonate, 1981, Volume: 39, Issue:3-4

    Topics: Alanine; Animals; Biological Transport; Female; Guinea Pigs; Ouabain; Perfusion; Permeability; Place

1981
Placental transfer of taurine in the rhesus monkey.
    The American journal of clinical nutrition, 1981, Volume: 34, Issue:12

    Topics: Alanine; Amino Acids; Animals; Dose-Response Relationship, Drug; Female; Fetal Blood; Infusions, Par

1981
Utilization of L-alanine and L-glutamine by lactating mammary gland of the rat. A role for L-alanine as a lipogenic precursor.
    The Biochemical journal, 1981, Jun-15, Volume: 196, Issue:3

    Topics: Alanine; Animals; Female; Glutamates; Glutamine; In Vitro Techniques; Lactation; Lipids; Liver; Mamm

1981
Substrate concentration changes during pregnancy in the conscious rat.
    Journal of developmental physiology, 1981, Volume: 3, Issue:6

    Topics: Alanine; Anesthesia; Animals; Blood Glucose; Body Weight; Eating; Fatty Acids, Nonesterified; Female

1981
Prematurity in the rat. II. Effect of hypothermia.
    Biology of the neonate, 1980, Volume: 37, Issue:3-4

    Topics: Adipose Tissue, Brown; Alanine; Animals; Animals, Newborn; Blood Glucose; Body Temperature Regulatio

1980
Renal gluconeogenesis in pregnant and non-pregnant sheep.
    The International journal of biochemistry, 1980, Volume: 11, Issue:3-4

    Topics: Alanine; Animals; Aspartic Acid; Female; Gluconeogenesis; Glutamates; Glutamine; Glycerol; Glycine;

1980
Placental metabolism and enzyme activities in diabetic pigs.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1980, Volume: 165, Issue:1

    Topics: Alanine; Alanine Transaminase; Alloxan; Animals; Aspartate Aminotransferases; Diabetes Mellitus, Exp

1980
Influence of acidosis and lactate on protein degradation in adult and fetal hearts.
    Journal of molecular and cellular cardiology, 1980, Volume: 12, Issue:10

    Topics: Acidosis; Alanine; Amino Acids; Amino Acids, Branched-Chain; Animals; Female; Heart; Lactates; Male;

1980
Stimulation of gluconeogenesis by cortisol in fetal rat liver in organ culture.
    Endocrinology, 1981, Volume: 108, Issue:4

    Topics: Alanine; Animals; Female; Fetus; Gluconeogenesis; Hydrocortisone; Kinetics; Liver; Liver Glycogen; O

1981
The transport of vitamin C in the isolated human near-term placenta.
    European journal of obstetrics, gynecology, and reproductive biology, 1995, Volume: 62, Issue:1

    Topics: Alanine; Ascorbic Acid; Biological Transport; Carrier Proteins; Cell Membrane; Cytochalasin B; Dehyd

1995
Isolation of syncytial microvillous membrane vesicles from human term placenta and their application in drug-nutrient interaction studies.
    Journal of pharmacological and toxicological methods, 1995, Volume: 34, Issue:1

    Topics: Alanine; Alkaline Phosphatase; Biological Transport; Calcium; Choline; Female; Food-Drug Interaction

1995
Plasma disposal rate and hepatic alanine metabolism in pregnant and nonpregnant rabbits.
    Pediatric research, 1995, Volume: 37, Issue:6

    Topics: Alanine; Animals; Catheterization; Fasting; Female; Glucose; Liver; Pregnancy; Pregnancy, Animal; Ra

1995
Thiocyanate ions selectively antagonize AMPA-evoked responses in Xenopus laevis oocytes microinjected with rat brain mRNA.
    British journal of pharmacology, 1993, Volume: 109, Issue:3

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Cell Me

1993
Functional characterization of L-alanine transport in a placental choriocarcinoma cell line (BeWo).
    Placenta, 1994, Volume: 15, Issue:8

    Topics: Alanine; beta-Alanine; Biological Transport; Choriocarcinoma; Colforsin; Female; Humans; Placenta; P

1994
The effects of cocaine on neutral amino acid uptake by human placental basal membrane vesicles.
    American journal of obstetrics and gynecology, 1994, Volume: 171, Issue:2

    Topics: Adult; Alanine; Binding Sites; Cell Membrane; Cocaine; Embryonic and Fetal Development; Female; Huma

1994
[The action of the fungicide alacide on the reproductive function of rats].
    Gigiena i sanitariia, 1993, Issue:1

    Topics: Alanine; Animals; Dose-Response Relationship, Drug; Estrus; Female; Fungicides, Industrial; Male; Pr

1993
Conformational states of human placental glutathione transferase as probed by limited proteolysis.
    Biochemical and biophysical research communications, 1993, Jul-30, Volume: 194, Issue:2

    Topics: Alanine; Amino Acid Sequence; Electrophoresis, Polyacrylamide Gel; Female; Glutathione Transferase;

1993
Cocaine inhibits alanine uptake by human placental microvillous membrane vesicles.
    American journal of obstetrics and gynecology, 1993, Volume: 169, Issue:3

    Topics: Adult; Alanine; Binding Sites; Biological Transport, Active; Chorionic Villi; Cocaine; Culture Techn

1993
Alanine and leucine transport in unfertilized pig oocytes and early blastocysts.
    Molecular reproduction and development, 1993, Volume: 34, Issue:3

    Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Animals; Biological Transport, Active; Blastocyst; Cell M

1993
Tumour growth results in changes in placental amino acid transport in the rat: a tumour necrosis factor alpha-mediated effect.
    The Biochemical journal, 1996, Jan-01, Volume: 313 ( Pt 1)

    Topics: Alanine; Amino Acid Transport Systems; Amino Acids; Animals; Biological Transport; Carrier Proteins;

1996
Alanine transport across the human placental brush border membrane and the role of SH groups in carrier function.
    Zeitschrift fur Ernahrungswissenschaft, 1995, Volume: 34, Issue:4

    Topics: 4-Chloromercuribenzenesulfonate; Alanine; Biological Transport; Female; Glutamic Acid; Humans; Kinet

1995
Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line.
    The Journal of biological chemistry, 1996, Aug-02, Volume: 271, Issue:31

    Topics: Alanine; Amino Acid Sequence; Amino Acid Transport System ASC; Amino Acid Transport Systems; Animals

1996
Lack of effect of cocaine on lysine and alanine uptake in human placental villi or transfer in perfused human placenta.
    Reproduction, fertility, and development, 1995, Volume: 7, Issue:6

    Topics: Alanine; Biological Transport; Chorionic Villi; Cocaine; Female; Humans; Kinetics; Lysine; Placenta;

1995
Intrauterine hypoxia-ischemia reduces phosphoinositide hydrolysis stimulated by metabotropic glutamate receptor agonists in cultured rat cerebellar granule cells.
    Brain research. Developmental brain research, 1996, May-31, Volume: 93, Issue:1-2

    Topics: Alanine; Animals; Brain Ischemia; Cell Count; Cells, Cultured; Cerebellum; Cycloleucine; Enzyme Inhi

1996
Effect of epidermal growth factor on placental amino acid transport and regulation of epidermal growth factor receptor expression of hepatocyte in rat.
    Journal of perinatal medicine, 1996, Volume: 24, Issue:3

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Antibodies; Binding, Competitive; Biological T

1996
Arrest of neuronal migration by excitatory amino acids in hamster developing brain.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Dec-24, Volume: 93, Issue:26

    Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; Animals; Animals, Newborn; Brain; Cell Differentiation;

1996
Neutral amino acid transport in placental plasma membrane vesicles in the late pregnant rat. Evidence for a B0-like transport system.
    European journal of obstetrics, gynecology, and reproductive biology, 1997, Volume: 71, Issue:1

    Topics: Alanine; Alkaline Phosphatase; Amino Acid Transport Systems; Animals; beta-Alanine; Biological Trans

1997
Effect of number of pig embryos in the uterus on their survival and development and on maternal metabolism.
    Journal of animal science, 1997, Volume: 75, Issue:5

    Topics: Alanine; Animals; Blood Glucose; Embryo, Mammalian; Embryonic and Fetal Development; Fatty Acids, No

1997
Glucose turnover and gluconeogenesis during pregnancy in women with and without insulin-dependent diabetes mellitus.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1997, Volume: 20, Issue:3

    Topics: Alanine; Carbon Isotopes; Deuterium; Diabetes Mellitus, Type 1; Estradiol; Fasting; Female; Glucagon

1997
Free amino acid distribution inside the first trimester human gestational sac.
    Early human development, 1998, May-29, Volume: 51, Issue:2

    Topics: Alanine; Amino Acids; Amniotic Fluid; Body Fluids; Female; Gestational Age; Glutamic Acid; Glycine;

1998
Proline, leucine, and alanine transport in placental microvillous membrane vesicles prepared from late gestational rats.
    The Journal of veterinary medical science, 1998, Volume: 60, Issue:10

    Topics: Alanine; Animals; Biological Transport; Female; Kinetics; Leucine; Microscopy, Electron; Microvilli;

1998
Relationship of fetal alanine uptake and placental alanine metabolism to maternal plasma alanine concentration.
    The American journal of physiology, 1998, Volume: 275, Issue:6

    Topics: Alanine; Amino Acids; Animals; Female; Fetal Blood; Fetus; Osmolar Concentration; Placenta; Pregnanc

1998
The phenotype of ostensibly healthy women who are carriers for ornithine transcarbamylase deficiency.
    Medicine, 1998, Volume: 77, Issue:6

    Topics: Adult; Aged; Alanine; Amino Acid Metabolism, Inborn Errors; Female; Glutamine; Heterozygote; Humans;

1998
Amniotic fluid homocysteine levels, 5,10-methylenetetrahydrafolate reductase genotypes, and neural tube closure sites.
    American journal of medical genetics, 2000, Jan-03, Volume: 90, Issue:1

    Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Alanine; Amino Acid Substitution; Amniotic Fluid;

2000
Role of amniotic fluid homocysteine level and of fetal 5, 10-methylenetetrahydrafolate reductase genotype in the etiology of neural tube defects.
    American journal of medical genetics, 2000, Jan-03, Volume: 90, Issue:1

    Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Alanine; Amino Acid Substitution; Amniotic Fluid;

2000
1H NMR as a non-invasive probe of amniotic fluid in insulin dependent diabetes mellitus.
    Journal of perinatal medicine, 1999, Volume: 27, Issue:5

    Topics: Acetates; Alanine; Amniotic Fluid; Citric Acid; Diabetes Mellitus, Type 1; Female; Glucose; Humans;

1999
The effect of oxytocin, prostaglandin E2 and acetylsalicylic acid on flow distribution and on the transfer of alanine, glucose and water in isolated perfused guinea pig placentae.
    Placenta, 2000, Volume: 21, Issue:1

    Topics: Alanine; Animals; Aspirin; Biological Transport, Active; Dinoprostone; Female; Glucose; Guinea Pigs;

2000
Alterations in basal glucose metabolism during late pregnancy in the conscious dog.
    American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alanine; Amino Acids; Animals; Arteries; Blood Glucose; Dogs;

2000
A serine/alanine polymorphism in the nucleotide-binding fold-2 of the sulphonylurea receptor-1 (S1369A) is associated with enhanced glucose-induced insulin secretion during pregnancy.
    Journal of inherited metabolic disease, 2000, Volume: 23, Issue:7

    Topics: Alanine; ATP-Binding Cassette Transporters; Binding Sites; Blood Glucose; C-Peptide; Codon; Diabetes

2000
Follicle-stimulating-hormone receptor and twinning.
    Lancet (London, England), 2001, Jan-20, Volume: 357, Issue:9251

    Topics: Alanine; Female; Humans; Mutation; Phenotype; Polymorphism, Genetic; Pregnancy; Pregnancy, Multiple;

2001
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo).
    European journal of pharmacology, 2001, Apr-13, Volume: 417, Issue:3

    Topics: 3-O-Methylglucose; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Alanine; Anticonvulsants; Biolo

2001
Fetal hepatic and umbilical uptakes of glucogenic substrates during a glucagon-somatostatin infusion.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:3

    Topics: Alanine; Animals; Arginine; Blood Glucose; Female; Fetal Blood; Gestational Age; Glucagon; Gluconeog

2002
Presence of the 5,10-methylenetetrahydrofolate reductase C677T mutation in Puerto Rican patients with neural tube defects.
    Journal of child neurology, 2002, Volume: 17, Issue:1

    Topics: Adult; Alanine; Alleles; Amino Acid Substitution; Female; Genetic Predisposition to Disease; Hispani

2002
[Effect of environment of the electric power plant Turów on the female body].
    Ginekologia polska, 1979, Volume: Suppl

    Topics: Alanine; Alanine Transaminase; Aspartate Aminotransferases; Aspartic Acid; Cystinyl Aminopeptidase;

1979
Activity staining for glutamate and alanine dehydrogenases in polyacrylamide gels of varying porosity. A study of bovine placental enzyme forms.
    Enzyme, 1979, Volume: 24, Issue:6

    Topics: Alanine; Amino Acid Oxidoreductases; Animals; Cattle; Electrophoresis, Polyacrylamide Gel; Female; G

1979
Taurine and other free amino acids in milk of man and other mammals.
    Early human development, 1978, Volume: 2, Issue:1

    Topics: Alanine; Amino Acids; Animals; Brain; Cats; Cattle; Dogs; Ethanolamines; Female; Glutamates; Glutami

1978
Fetal pancreatic glucagon responses in glucose-intolerant nonhuman primate pregnancy.
    American journal of obstetrics and gynecology, 1977, Feb-01, Volume: 127, Issue:3

    Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus; Female; Glucagon; Haplorhini; Levodopa; Macaca m

1977
Sodium-dependent amino acid transport in preimplantation mouse embryos. III. Na+-k+-atpase-linked mechanism in blastocysts.
    Developmental biology, 1977, Volume: 59, Issue:2

    Topics: Adenosine Triphosphatases; Alanine; Animals; Blastocyst; Cytochalasin B; Dimethyl Sulfoxide; Embryon

1977
Hormonal regulation of incorporation of alanine-U-14C into glucose in human fetal liver explants. Effect of dibutyryl cyclic AMP, glucagon, insulin, and triamcinolone.
    Diabetes, 1975, Volume: 24, Issue:7

    Topics: Alanine; Bucladesine; Drug Synergism; Female; Fetus; Glucagon; Gluconeogenesis; Humans; Insulin; Kin

1975
Ontogeny of gluconeogenesis in the bovine fetus: influence of maternal dietary energy.
    Developmental biology, 1977, Jul-15, Volume: 58, Issue:2

    Topics: Alanine; Animal Nutritional Physiological Phenomena; Animals; Aspartate Aminotransferases; Aspartic

1977
[Pyruvate-dehydrogenase deficiency. Lethal course of the disease during infancy (author's transl)].
    Monatsschrift fur Kinderheilkunde, 1978, Volume: 126, Issue:3

    Topics: Acidosis; Alanine; Carbohydrate Metabolism, Inborn Errors; Female; Humans; Infant; Infant, Newborn;

1978
Transfer of glutamic acid across the human placenta perfused in vitro.
    British journal of obstetrics and gynaecology, 1979, Volume: 86, Issue:4

    Topics: Alanine; Aspartic Acid; Female; Glutamates; Glutamine; Glycine; Humans; In Vitro Techniques; Leucine

1979
Alanine transport across in vitro rabbit vagina.
    Contraception, 1979, Volume: 19, Issue:4

    Topics: Alanine; Animals; Biological Transport; Castration; Electric Stimulation; Epithelium; Estrus; Female

1979
Transfer of amino acids across the in vitro perfused human placenta.
    Pediatric research, 1979, Volume: 13, Issue:4 Pt 1

    Topics: Alanine; Amino Acids; Female; Humans; In Vitro Techniques; Leucine; Maternal-Fetal Exchange; Perfusi

1979
The G gamma:A gamma composition of fetal hemoglobin in fetuses and newborns.
    Blood, 1979, Volume: 54, Issue:5

    Topics: Alanine; Anemia, Sickle Cell; Electrophoresis, Polyacrylamide Gel; Female; Fetal Hemoglobin; Fetus;

1979
The effect of alpha-aminoisobuturic acid and 2,4-diaminobuturic acid on mouse blastocyst outgrowth in vitro.
    Acta physiologica Scandinavica, 1979, Volume: 107, Issue:1

    Topics: Alanine; Amino Acids, Diamino; Aminobutyrates; Aminoisobutyric Acids; Animals; Blastocyst; Cells, Cu

1979
[Activity of various enzymes in the blood of pregnant women and their fetuses with low body weight].
    Ginekologia polska, 1979, Volume: Suppl

    Topics: Alanine; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Aspartic Acid; Cre

1979
The effect of L-aspartic acid, L-alanine, and hemoglobin on trypan blue-induced embryolethality and gross fetal malformations in gestating albino mice.
    Toxicology and applied pharmacology, 1977, Volume: 42, Issue:2

    Topics: Abnormalities, Drug-Induced; Alanine; Animals; Aspartic Acid; Body Weight; Drug Interactions; Female

1977
Effect of protein-bound lysinoalanine, N epsilon-DL-(2-amino-2-carboxyethyl)-L-lysine on fetal and neonatal rats.
    The Journal of nutrition, 1978, Volume: 108, Issue:6

    Topics: Alanine; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Fetus; Glycine max; La

1978
Ammonia overloading in hepatocytes isolated from liver of fetal and adult rats.
    Biochimica et biophysica acta, 1979, Sep-03, Volume: 586, Issue:3

    Topics: Alanine; Aminooxyacetic Acid; Ammonia; Animals; Aspartic Acid; Female; Fructose; Glucose; Glutamates

1979
Gluconeogenesis from alanine in vivo by the ovine fetus and lamb.
    The American journal of physiology, 1977, Volume: 233, Issue:6

    Topics: Alanine; Amino Acids; Animals; Blood Glucose; Female; Fetus; Gluconeogenesis; Glucose; Lactates; Pre

1977
Kinetics of pyruvate kinase from human placenta [proceedings].
    Biochemical Society transactions, 1977, Volume: 5, Issue:6

    Topics: Alanine; Female; Fructosediphosphates; Humans; Isoenzymes; Kinetics; Lung; Muscles; Placenta; Pregna

1977
The immediate effect of a beta-adrenergic agonist (salbutamol) on carbohydrate and lipid metabolism during the third trimester of pregnancy.
    Acta obstetricia et gynecologica Scandinavica, 1977, Volume: 56, Issue:5

    Topics: Adolescent; Adult; Alanine; Albuterol; Blood Glucose; C-Peptide; Carbohydrate Metabolism; Drug Evalu

1977
Cluconeogenesis from alanine in vivo by the ovine fetus and lamb.
    The American journal of physiology, 1978, Volume: 235, Issue:4

    Topics: Alanine; Animals; Female; Fetus; Gluconeogenesis; Glucose; Maternal-Fetal Exchange; Pregnancy; Sheep

1978
Effect of intravenous hydrocortisone administration on glucose homeostasis in small for gestational age infants.
    Acta paediatrica Scandinavica, 1979, Issue:1

    Topics: Alanine; Blood Glucose; Female; Gluconeogenesis; Glucose; Homeostasis; Humans; Hydrocortisone; Hypog

1979
Blunting of spontaneous and alanine-stimulated glucagon secretion in newborn infants of diabetic mothers.
    American journal of obstetrics and gynecology, 1979, Jan-01, Volume: 133, Issue:1

    Topics: Alanine; Blood Glucose; Female; Glucagon; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Di

1979
Comparison of the anti-LH/FSH-RH and anti-ovulatory activities of (D-Phe2, D-Leu6)-LH-RH and (D-Phe2, D-Ala6)-LH-RH.
    Endocrine research communications, 1976, Volume: 3, Issue:3-4

    Topics: Alanine; Animals; Estrus; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Leuc

1976
Turnover of alanine and glycine in foetal and suckling lambs.
    The Proceedings of the Nutrition Society, 1977, Volume: 36, Issue:1

    Topics: Alanine; Animals; Female; Fetus; Gestational Age; Glycine; Lactation; Pregnancy; Sheep

1977
Hepatic gluconeogenesis in foetal and suckling lambs.
    The Proceedings of the Nutrition Society, 1976, Volume: 35, Issue:1

    Topics: Alanine; Animals; Female; Glucagon; Gluconeogenesis; Lactates; Lactation; Liver; Liver Glycogen; Pre

1976
Cholinomimetic teratogens. III. Interaction with amino acids known as neurotransmitters.
    Teratology, 1976, Volume: 13, Issue:1

    Topics: Alanine; Animals; Carbachol; Chick Embryo; Decamethonium Compounds; Female; Fetal Death; gamma-Amino

1976
Suceptibility of mice to audiogenic seizures is increased by handling their dams during gestation.
    Science (New York, N.Y.), 1976, Jul-30, Volume: 193, Issue:4251

    Topics: Alanine; Animals; Female; Mice; Pregnancy; Pregnancy, Animal; Seizures; Sound; Stress, Physiological

1976
Endocrine-metabolic response to acute starvation in human gestation.
    American journal of obstetrics and gynecology, 1976, Aug-15, Volume: 125, Issue:8

    Topics: Abortion, Therapeutic; Acute Disease; Alanine; Amino Acids; Amniotic Fluid; Arginine; Blood Glucose;

1976
The regulation of uptake and output of amino acids by rat tissues.
    Advances in enzyme regulation, 1976, Volume: 14

    Topics: Adipose Tissue; Alanine; Amino Acids; Animals; Carcinoma 256, Walker; Diet; Fasting; Female; Fetus;

1976
Effect of pregnancy on serum alanine concentration in normal and genetically diabetic mice.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1976, Volume: 8, Issue:6

    Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus; Fasting; Female; Pregnancy; Pregnancy in Diabeti

1976
Glucose homeostasis during the perinatal period.
    Progress in clinical and biological research, 1976, Volume: 10

    Topics: Alanine; Amino Acids; Animals; Blood Glucose; Fatty Acids, Nonesterified; Female; Fetus; Glucagon; G

1976
Variations in some plasma metabolites from neoglucogenesis and ketogenesis in pregnant ewes in relation to diet.
    Annales de recherches veterinaires. Annals of veterinary research, 1976, Volume: 7, Issue:4

    Topics: Acetates; Alanine; Animals; Blood Glucose; Fatty Acids, Nonesterified; Feeding Behavior; Female; Glu

1976
Effect of maternal ethanol consumption of fetal hepatic metabolism in the rat.
    Annals of the New York Academy of Sciences, 1976, Volume: 273

    Topics: Alanine; Alcohol Oxidoreductases; Alcoholic Intoxication; Animals; Bicarbonates; Carbon Dioxide; Eth

1976
Plasma glucagon and insulin in rat pregnancy. Roles in glucose homeostasis.
    The Journal of clinical investigation, 1975, Volume: 55, Issue:1

    Topics: Alanine; Anesthesia; Animals; Antigens; Blood Glucose; Female; Glucagon; Glucose; Homeostasis; Insul

1975
Dipeptidase activity in the small intestinal mucosa during pregnancy and lactation in the rat.
    The British journal of nutrition, 1975, Volume: 33, Issue:1

    Topics: Alanine; Animals; Dipeptidases; Feeding Behavior; Female; Glutamates; Glycine; Intestinal Mucosa; In

1975
Blunted response to oral alanine feeding in small-for-gestational-age infants.
    Nutrition reviews, 1975, Volume: 33, Issue:6

    Topics: Alanine; Birth Weight; Blood Glucose; Female; Gestational Age; Glucagon; Gluconeogenesis; Humans; In

1975
Size of L-lactate transport from the fetal rat to the mother animal.
    Biology of the neonate, 1975, Volume: 26, Issue:1-2

    Topics: Alanine; Animals; Female; Fetus; Lactates; Liver; Maternal-Fetal Exchange; Placenta; Pregnancy; Prot

1975
Pyruvate kinase isoenzymes in tissues of the developing guinea pig.
    Archives of biochemistry and biophysics, 1975, Volume: 170, Issue:1

    Topics: Age Factors; Alanine; Animals; Animals, Newborn; Brain; Female; Fetus; Guinea Pigs; Isoenzymes; Kidn

1975
Hyperaminoacidemia due to the accumulation of gluconeogenic amino acid precursors in hypoglycemic small-for-gestational age infants.
    The Journal of pediatrics, 1975, Volume: 87, Issue:3

    Topics: Alanine; Amino Acids; Birth Weight; Female; Gestational Age; Gluconeogenesis; Glycine; Humans; Hypog

1975
Free amino acids in plasma and tissue of rats born to underfed dams.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1975, Volume: 148, Issue:4

    Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Arginine; Body Weight; Female; Glutamates; Glycine;

1975
Developmental changes of free amino acids in bovine fetal fluids with gestational age and the interrelationships between the amino acid concentrations in the fluid compartments.
    Journal of reproduction and fertility, 1975, Volume: 44, Issue:3

    Topics: Alanine; Allantois; Amino Acids; Amniotic Fluid; Animals; Body Fluids; Cattle; Female; Fetal Blood;

1975
[Free amino acids in the amniotic fluid and in maternal blood in advanced pregnancy].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1975, Volume: 4, Issue:7

    Topics: Alanine; Amino Acids; Amniotic Fluid; Cysteine; Female; Glycine; Histidine; Humans; Isoleucine; Leuc

1975
[The pattern of distribution of free amino acids in human amniotic fluid related to the duration of pregnancy. Part I: Changes in concentration in normal pregnancy (author's transl)].
    Zeitschrift fur Geburtshilfe und Perinatologie, 1976, Volume: 180, Issue:1

    Topics: Alanine; Amino Acids; Amniotic Fluid; Chromatography, Gas; Cysteine; Female; Gestational Age; Glycin

1976
Kinetic properties of pyruvate kinase in human maternal leukocytes in fetal malnutrition.
    Pediatric research, 1976, Volume: 10, Issue:6

    Topics: Alanine; Allosteric Regulation; Female; Fructosephosphates; Glycolysis; Humans; Kinetics; Leukocytes

1976
Human endometrial stromal cells and decidual cells express cluster of differentiation (CD) 13 antigen/aminopeptidase N and CD10 antigen/neutral endopeptidase.
    Biology of reproduction, 1992, Volume: 46, Issue:3

    Topics: Adult; Alanine; Aminopeptidases; Aniline Compounds; Antigens, CD; Antigens, Differentiation; Antigen

1992
Amino acid gradients across the intestinal circulation in fetal lambs.
    Journal of developmental physiology, 1992, Volume: 17, Issue:3

    Topics: Alanine; Ammonia; Animals; Blood Gas Analysis; Female; Fetus; Gestational Age; Glutamates; Glutamic

1992
Heterogeneity of L-alanine transport systems in brush-border membrane vesicles from rat placenta during late gestation.
    The Biochemical journal, 1992, Nov-15, Volume: 288 ( Pt 1)

    Topics: Alanine; Aminoisobutyric Acids; Animals; Anions; Biological Transport; Cations; Female; Kinetics; Me

1992
Glucose-alanine relationship in diabetes in human pregnancy.
    Metabolism: clinical and experimental, 1991, Volume: 40, Issue:6

    Topics: Adult; Alanine; Blood Glucose; Carbon Dioxide; Diabetes Mellitus, Type 1; Female; Humans; Oxygen Con

1991
In vivo alanine metabolism in late pregnant rats.
    Biochemistry international, 1990, Volume: 22, Issue:4

    Topics: Administration, Oral; Alanine; Animals; Blood Glucose; Female; Fetus; Glucose; Glycogen; Liver; Live

1990
Development of system B0,+ and a broad-scope Na(+)-dependent transporter of zwitterionic amino acids in preimplantation mouse conceptuses.
    Biochimica et biophysica acta, 1990, Jun-27, Volume: 1025, Issue:2

    Topics: Alanine; Amino Acids; Animals; Biological Transport; Blastocyst; Cleavage Stage, Ovum; Embryo Implan

1990
Chronic hypoxia in neuronal cell culture: metabolic consequences.
    Brain & development, 1990, Volume: 12, Issue:3

    Topics: Alanine; Animals; Bicarbonates; Binding, Competitive; Brain Chemistry; Cell Hypoxia; Cells, Cultured

1990
Maternal and cord blood plasma. Comparative analyses by 1H NMR spectroscopy.
    NMR in biomedicine, 1989, Volume: 2, Issue:2

    Topics: Acute-Phase Proteins; Alanine; Blood Chemical Analysis; Ethanol; Female; Fetal Blood; Glycoproteins;

1989
Role of the gamma-glutamyl cycle in the regulation of amino acid translocation.
    The American journal of physiology, 1989, Volume: 257, Issue:6 Pt 1

    Topics: Alanine; Amino Acids; Animals; Biological Transport; Female; Fetus; gamma-Glutamyltransferase; Gluco

1989
Effects of 5-hydroxytryptamine uptake blockers on the concentration in brain of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in male rats, pro-oestrous rats and ovariectomized rats treated with oestrogen and progesterone.
    The Journal of endocrinology, 1985, Volume: 104, Issue:3

    Topics: Alanine; Animals; Brain; Castration; Estradiol; Female; Hydroxyindoleacetic Acid; Hypothalamus; Male

1985
Pharmacological study of a traditional Chinese medicine: effect of bezoar bovis on the irregular beating pattern of cultured mouse myocardial cells.
    Research communications in chemical pathology and pharmacology, 1989, Volume: 63, Issue:3

    Topics: Alanine; Amino Acids; Animals; Bezoars; Calcium; Electrolytes; Female; Heart; Medicine, Chinese Trad

1989
Na+-dependent alanine transport in plasma membrane vesicles from late-pregnant rat livers.
    Pediatric research, 1989, Volume: 26, Issue:5

    Topics: Alanine; Animals; Biological Transport, Active; Cell Membrane; Female; Kinetics; Liver; Nitrogen; Pr

1989
Enhanced cerebral substrate pools in the fetus and neonate of the diabetic canine mother.
    Diabetes, 1985, Volume: 34, Issue:2

    Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Brain; Carbohydrate Metabolism; Cerebral Cortex; Do

1985
Histochemical demonstration of exopeptidases in the rat visceral yolk-sac epithelium.
    Histochemistry, 1985, Volume: 82, Issue:4

    Topics: Alanine; Amidines; Aminopeptidases; Animals; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Pepti

1985
A single amino acid substitution in an ectopic alpha subunit of a human carcinoma choriogonadotropin.
    The Journal of biological chemistry, 1986, Aug-15, Volume: 261, Issue:23

    Topics: Alanine; Amino Acid Sequence; Chorionic Gonadotropin; Circular Dichroism; Female; Glutamates; Glutam

1986
A spectrophotometric method for the determination of gamma-glutamyl cyclotransferase with alanine dehydrogenase in the presence of anthglutin.
    Biochemical medicine and metabolic biology, 1987, Volume: 38, Issue:3

    Topics: Acyltransferases; Alanine; Alanine Dehydrogenase; Amino Acid Oxidoreductases; Animals; Buffers; Eryt

1987
Glucose-alanine relationship in normal human pregnancy.
    Metabolism: clinical and experimental, 1989, Volume: 38, Issue:3

    Topics: Alanine; Animals; Female; Glucose; Humans; Pregnancy; Rats

1989
Alanine transport systems in isolated basal plasma membrane of human placenta.
    The American journal of physiology, 1989, Volume: 256, Issue:3 Pt 1

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Biological Transport; Cell Membrane; Cysteine; Dihydroa

1989
Alterations of fasting glucose and fat metabolism in intrauterine growth-retarded newborn dogs.
    The American journal of physiology, 1989, Volume: 256, Issue:3 Pt 1

    Topics: Aging; Alanine; Animals; Animals, Newborn; Blood Glucose; Disease Models, Animal; Dogs; Energy Metab

1989
Increased gluconeogenesis in the rat at term gestation.
    Life sciences, 1985, Aug-12, Volume: 37, Issue:6

    Topics: Alanine; Animals; Bicarbonates; Blood Glucose; Carbon Radioisotopes; Female; Fructose-Bisphosphatase

1985
[The effect of inorganic mercury on placental amino acid transport using microvillous membrane vesicles].
    Nihon Sanka Fujinka Gakkai zasshi, 1987, Volume: 39, Issue:2

    Topics: Alanine; Amino Acids; Biological Transport; Female; Humans; Lysine; Mercury; Micropore Filters; Micr

1987
[Study on human placental beta-alanine and taurine transport mechanism (using microvillous membrane vesicles].
    Nihon Sanka Fujinka Gakkai zasshi, 1987, Volume: 39, Issue:6

    Topics: Alanine; beta-Alanine; Biological Transport; Female; Humans; Ions; Microvilli; Placenta; Pregnancy;

1987
Glucose-alanine relationship in normal human pregnancy.
    Metabolism: clinical and experimental, 1988, Volume: 37, Issue:2

    Topics: Adult; Alanine; Body Weight; Carbon Dioxide; Female; Gluconeogenesis; Glucose; Hormones; Humans; Lac

1988
Effects of 5-hydroxytryptamine uptake blockers on the release of LH and prolactin in several different experimental steroid models in the rat.
    The Journal of endocrinology, 1985, Volume: 104, Issue:3

    Topics: Alanine; Animals; Castration; Estradiol; Female; Luteinizing Hormone; Pituitary Gland, Anterior; Pre

1985
Alanine turnover rate and its hepatic metabolism are increased in midpregnant rat.
    Biology of the neonate, 1988, Volume: 54, Issue:3

    Topics: Alanine; Animals; Female; Liver; Metabolic Clearance Rate; Pregnancy; Pregnancy, Animal; Rats; Rats,

1988
Analogues of luteinizing hormone-releasing hormone (LH-RH) containing dehydroalanine in 6th position.
    International journal of peptide and protein research, 1988, Volume: 31, Issue:2

    Topics: Alanine; Chorionic Gonadotropin; Female; Gonadotropin-Releasing Hormone; Humans; Indicators and Reag

1988
Neutral amino acid transport systems of microvillous membrane of human placenta.
    The American journal of physiology, 1988, Volume: 254, Issue:6 Pt 1

    Topics: Alanine; Amino Acids; Aminobutyrates; Biological Transport, Active; Cysteine; Female; Humans; Leucin

1988
Maternal-fetal relationship in ammonia metabolism during late gestation in the rat.
    Biology of the neonate, 1988, Volume: 53, Issue:5

    Topics: Alanine; Allantoin; Ammonia; Amniotic Fluid; Animals; Female; Fetal Blood; Glutamates; Glutamine; Ma

1988
Changes to metabolite concentration in fetal sheep subjected to prolonged hypobaric hypoxia.
    Journal of developmental physiology, 1988, Volume: 10, Issue:2

    Topics: Alanine; Altitude Sickness; Animals; Atmospheric Pressure; Blood Glucose; Body Weight; Embryonic and

1988
[The changes in EPH gestosis placental amino acid transport activity (using human placental microvillous membrane vesicles)].
    Nihon Sanka Fujinka Gakkai zasshi, 1987, Volume: 39, Issue:10

    Topics: Alanine; Alkaline Phosphatase; Amino Acids; Biological Transport, Active; Female; Humans; Microvilli

1987
Effects of in vivo administration of growth hormone on milk production and in vitro hepatic metabolism in dairy cattle.
    Journal of dairy science, 1986, Volume: 69, Issue:3

    Topics: Acetoacetates; Alanine; Animals; Blood Glucose; Butyrates; Cattle; Fatty Acids, Nonesterified; Femal

1986
Comparative utilization of glycerol and alanine as liver gluconeogenic substrates in the fed late pregnant rat.
    The International journal of biochemistry, 1986, Volume: 18, Issue:7

    Topics: Alanine; Animals; Carbon Radioisotopes; Eating; Female; Gluconeogenesis; Glycerol; Liver; Pregnancy;

1986
Effect of feed intake level in late gestation on arterial blood concentrations of energy substrates, insulin and glucagon in the chronically catheterized gilt.
    Reproduction, nutrition, developpement, 1987, Volume: 27, Issue:1A

    Topics: Alanine; Animals; Blood Glucose; Eating; Fatty Acids, Nonesterified; Female; Glucagon; Insulin; Keto

1987
Lactate production and absence of gluconeogenesis from placental transferred substrates in fetuses from fed and 48-H starved rats.
    Pediatric research, 1987, Volume: 22, Issue:1

    Topics: Alanine; Animals; Carbon Radioisotopes; Fatty Acids; Female; Gestational Age; Gluconeogenesis; Gluco

1987
[The character of human placental glucose and amino acid transport activity (using microvillous membrane vesicles)].
    Nihon Sanka Fujinka Gakkai zasshi, 1987, Volume: 39, Issue:9

    Topics: Alanine; Amino Acids; Biological Transport; Female; Glucose; Humans; Microvilli; Placenta; Pregnancy

1987
[Study on changes in placental L-alanine transport activity during gestation (using microvillous membrane vesicles].
    Nihon Sanka Fujinka Gakkai zasshi, 1986, Volume: 38, Issue:4

    Topics: Alanine; Female; Humans; Intracellular Membranes; Microvilli; Placenta; Pregnancy; Pregnancy Trimest

1986
L-alanine carriers at maternal and fetal surfaces of the guinea pig placenta trophoblast.
    Gynecologic and obstetric investigation, 1986, Volume: 22, Issue:4

    Topics: Alanine; Animals; Biological Transport, Active; Female; Guinea Pigs; In Vitro Techniques; Kinetics;

1986
[Study on Na+ and L-alanine cotransport of the human placenta using microvillous membrane vesicles].
    Nihon Sanka Fujinka Gakkai zasshi, 1987, Volume: 39, Issue:1

    Topics: Alanine; Biological Transport; Female; Humans; In Vitro Techniques; Ions; Membrane Potentials; Micro

1987
Alanine uptake by liver at midpregnancy in rats.
    The American journal of physiology, 1987, Volume: 252, Issue:3 Pt 1

    Topics: Alanine; Aminoisobutyric Acids; Animals; Biological Transport, Active; Female; Kinetics; Liver; Orga

1987
Altered growth, hypoglycemia, hypoalaninemia, and ketonemia in the young rat: postnatal consequences of intrauterine growth retardation.
    Pediatric research, 1985, Volume: 19, Issue:1

    Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Animals, Newborn; Body Weight; Brain; DNA; Female; Fetal Gr

1985
The effects of chronic fetal hyperglycemia on substrate uptake by the ovine fetus and conceptus.
    Pediatric research, 1985, Volume: 19, Issue:7

    Topics: Alanine; Animals; Arteries; Blood; Blood Glucose; Chronic Disease; Embryo, Mammalian; Female; Fetal

1985
Na+-dependent transport of basic, zwitterionic, and bicyclic amino acids by a broad-scope system in mouse blastocysts.
    The Journal of biological chemistry, 1985, Oct-05, Volume: 260, Issue:22

    Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Amino Acids, Diamino; Animals; Biological Transport; Blas

1985
Alanine and lactate as gluconeogenic substrates during late gestation.
    FEBS letters, 1986, Jan-06, Volume: 194, Issue:2

    Topics: Alanine; Animals; Diet; Female; Gluconeogenesis; Glucose; In Vitro Techniques; Lactates; Lactic Acid

1986
Role of the availability of substrates on hepatic and renal gluconeogenesis in the fasted late pregnant rat.
    Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4

    Topics: Alanine; Animals; Carbon Radioisotopes; Fasting; Female; Gluconeogenesis; Glucose; Glycerol; In Vitr

1986
Contragestational profile of the tumor-inhibiting agent, L-alanosine, in the rat and the hamster.
    Cancer chemotherapy and pharmacology, 1985, Volume: 14, Issue:1

    Topics: Adenine; Alanine; Animals; Antibiotics, Antineoplastic; Aspartic Acid; Cell Division; Cricetinae; Do

1985
Gluconeogenesis by the fetal sheep liver in vivo.
    Journal of developmental physiology, 1985, Volume: 7, Issue:3

    Topics: Alanine; Animals; Carbon Radioisotopes; Female; Fetus; Gluconeogenesis; Glucose; Lactates; Liver; Pr

1985
Placental formation of lactate from transferred L-alanine and its impairment by aminooxyacetate in the late-pregnant rat.
    Biochimica et biophysica acta, 1985, Jul-26, Volume: 841, Issue:1

    Topics: Acetates; Alanine; Aminoisobutyric Acids; Aminooxyacetic Acid; Animals; Female; Lactates; Lactic Aci

1985
Ketone body metabolism during pregnancy in the rabbit.
    Reproduction, nutrition, developpement, 1985, Volume: 25, Issue:3

    Topics: Alanine; Amino Acids; Animals; Body Weight; Butyrates; Butyric Acid; Carnitine; Eating; Fasting; Fat

1985
Effects of acetaldehyde and/or ethanol on neutral amino acid transport systems in microvillous brush border membrane vesicles prepared from human placenta.
    Experientia, 1985, Dec-15, Volume: 41, Issue:12

    Topics: Acetaldehyde; Alanine; Amino Acids; Biological Transport, Active; Depression, Chemical; Ethanol; Fem

1985
Dynamics of axoplasmic transport in the optic system of the rat.
    Experimental brain research, 1974, Volume: 21, Issue:1

    Topics: Alanine; Animals; Asparagine; Axonal Transport; Circadian Rhythm; Estrus; Female; Leucine; Male; Neu

1974
[Enzyme activity of human milk in relation to amino acid arylamides].
    Acta biologica et medica Germanica, 1973, Volume: 30, Issue:5

    Topics: Acyltransferases; Adolescent; Adult; Alanine; Amides; Amidohydrolases; Arginine; Cobalt; Edetic Acid

1973
[Value of congestive enzymes in liver and biliary tract diseases].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1973, Sep-15, Volume: 28, Issue:18

    Topics: Alanine; Alkaline Phosphatase; Aminopeptidases; Biliary Tract Diseases; Bone Diseases; Cholestasis;

1973
Learning in monkeys fed elevated amino acid diets.
    Journal of medical primatology, 1973, Volume: 2, Issue:3

    Topics: Alanine; Amino Acids; Animals; Diet; Discrimination Learning; Female; Food; Glycine; Haplorhini; His

1973
Pyruvate dehydrogenase, the citrate condensing enzyme and the utilization of 14 C-labeled lactate, pyruvate and alanine by slices of lactating mammary gland and adenocarcinoma of mouse mammary gland.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 142, Issue:3

    Topics: Adenocarcinoma; Alanine; Amino Acids; Animals; Carbon Dioxide; Carbon Isotopes; Citrate (si)-Synthas

1973
The effect of angiotensin-II intravenous infusion on plasma renin activity and prostaglandins A, E, and F levels in the uterine vein of the pregnant monkey.
    Prostaglandins, 1974, May-25, Volume: 6, Issue:4

    Topics: Alanine; Angiotensin II; Animals; Blood Pressure; Depression, Chemical; Female; Glucose; Haplorhini;

1974
Hormonal regulation of amino acid accumulation in human fetal liver explants. Effects of dibutyryl cyclic AMP, glucogon and insulin.
    Biochimica et biophysica acta, 1974, Sep-05, Volume: 362, Issue:2

    Topics: Alanine; Aminoisobutyric Acids; Biological Transport; Bucladesine; Carbon Radioisotopes; Cycloheximi

1974
The role of the phagocyte in host-parasite interactions. XXV. Metabolic and bactericidal activities of leukocytes from pregnant women.
    American journal of obstetrics and gynecology, 1970, Nov-01, Volume: 108, Issue:5

    Topics: Alanine; Animals; Bacteriuria; Blood Bactericidal Activity; Carbon Isotopes; Carboxy-Lyases; Escheri

1970
Hydroxyproline in the allantoic fluid of the mare.
    Journal of reproduction and fertility, 1970, Volume: 23, Issue:3

    Topics: Adrenergic beta-Agonists; Alanine; Animals; Body Fluids; Chromatography; Female; Glutamates; Glycine

1970
Separation of glycogen formation and aminotransferase activity induced by cortisol in fetal rat liver.
    Endocrinology, 1972, Volume: 91, Issue:1

    Topics: Alanine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Boron Compounds; Carbon Isotope

1972
Amino acid transport in human placental slices.
    American journal of obstetrics and gynecology, 1974, Dec-15, Volume: 120, Issue:8

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Aspartic Acid; Biological Transport,

1974
A new structural haemoglobinopathy found in an Indian in Singapore--Hb Meerut alpha120 ALA leads to GLU.
    The Journal of the Singapore Paediatric Society, 1974, Volume: 16, Issue:2

    Topics: Adult; Alanine; Anemia; Female; Glutamates; Hemoglobinopathies; Hemoglobins, Abnormal; Humans; India

1974
Determination of portal and hepatic metabolite production rates in the adult dairy cow.
    The Proceedings of the Nutrition Society, 1974, Volume: 33, Issue:3

    Topics: Alanine; Animals; Carotid Arteries; Cattle; Digestive System; Fatty Acids, Volatile; Female; Glucose

1974
Amino acid and glucose uptake by the isolated perfused guinea-pig mammary gland.
    Quarterly journal of experimental physiology and cognate medical sciences, 1974, Volume: 59, Issue:2

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Carbon Radioisotopes; Caseins; Female; Glucose; Glutam

1974
Glucagon metabolism in nonhuman primate pregnancy.
    American journal of obstetrics and gynecology, 1974, Nov-01, Volume: 120, Issue:5

    Topics: Alanine; Amniotic Fluid; Animals; Animals, Newborn; Blood Glucose; Fasting; Female; Fetus; Gestation

1974
[Blood-brain barrier and placental barrier for various amino acids in the mouse (whole body autoradiography studies)].
    Beitrage zur Pathologie, 1972, Volume: 147, Issue:4

    Topics: Alanine; Amino Acids; Animals; Autoradiography; Blood-Brain Barrier; Cell Membrane Permeability; Fem

1972
Variations in the concentrations of free amino acids in the plasma of the dairy cow at parturition.
    The Journal of dairy research, 1972, Volume: 39, Issue:3

    Topics: Alanine; Amino Acids; Animals; Cattle; Female; Glycine; Isoleucine; Postpartum Period; Pregnancy; Ti

1972
Effects of mother-litter separation on survival, growth, and brain amino acid levels.
    Physiology & behavior, 1972, Volume: 8, Issue:1

    Topics: Alanine; Amino Acids; Aminobutyrates; Animal Nutritional Physiological Phenomena; Animals; Animals,

1972
Concentration of alpha-amino nitrogen and free amino acid in the uterine and blastocoelic fluid of rabbit.
    Acta Europaea fertilitatis, 1972, Volume: 3, Issue:3

    Topics: Alanine; Amines; Amino Acids; Amniotic Fluid; Animals; Asparagine; Autoanalysis; Blastocyst; Castrat

1972
The effect of intravenous glucagon on plasma amino acids in the newborn.
    Pediatric research, 1973, Volume: 7, Issue:4

    Topics: Alanine; Amino Acids; Birth Weight; Blood Glucose; Female; Gestational Age; Glucagon; Gluconeogenesi

1973
Further characterization of haemoglobin F Hull 121 glutamic acid leads to lysine; 136 alanine.
    Biochimica et biophysica acta, 1973, Apr-20, Volume: 303, Issue:2

    Topics: Adult; Alanine; Amino Acid Sequence; Amino Acids; Chromatography, Gel; Chromatography, Ion Exchange;

1973
The free amino acids in maternal and fetal extracellular fluids collected during ealy pregnancy.
    American journal of obstetrics and gynecology, 1973, Jul-15, Volume: 116, Issue:6

    Topics: Abortion, Therapeutic; Alanine; Amino Acids; Aminoisobutyric Acids; Amniotic Fluid; Chromatography;

1973
Haemoglobin J Nyanza: 21 (B2) Ala-Asp.
    Biochimica et biophysica acta, 1973, Jun-15, Volume: 310, Issue:2

    Topics: Adult; Alanine; Amino Acid Sequence; Amino Acids; Aspartic Acid; Chromatography, Ion Exchange; Elect

1973
Evidence of stimulation of glucagon secretion by alanine in the human fetus at term.
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 37, Issue:2

    Topics: Adult; Alanine; Blood Glucose; Female; Fetus; Glucagon; Humans; Pregnancy; Umbilical Veins

1973
Carbohydrate metabolism in pregnancy. X. Metabolic disposition of alanine by the perfused liver of the fasting pregnant rat.
    Diabetes, 1973, Volume: 22, Issue:8

    Topics: Alanine; Alanine Transaminase; Ammonia; Animals; Aspartic Acid; Carbon Isotopes; Chromatography; Fas

1973
The utilization of 14 C-labeled lactate, pyruvate and alanine by prelactating tissues and hyperplastic alveolar nodule outgrowths.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 142, Issue:3

    Topics: Alanine; Amino Acids; Animals; Carbon Dioxide; Carbon Isotopes; Citrate (si)-Synthase; Fatty Acids;

1973
The G and A hemoglobin chains during human fetal development.
    American journal of human genetics, 1973, Volume: 25, Issue:3

    Topics: Alanine; Chromatography, Gel; Embryonic and Fetal Development; Female; Fetal Hemoglobin; Fetus; Glyc

1973
Rat brain and blood gluconeogenic metabolic changes in neonatal starvation.
    Brain research, 1973, Jul-16, Volume: 57, Issue:1

    Topics: Age Factors; Alanine; Amino Acids; Animals; Animals, Newborn; Brain; Female; Food Deprivation; Gluco

1973
[Estimation of serum arylamidase with L-alanine-p-nitroanilide as a substrate. The question of optimal "LAP" tests].
    Zeitschrift fur klinische Chemie und klinische Biochemie, 1973, Volume: 11, Issue:8

    Topics: Alanine; Aminopeptidases; Anilides; Costs and Cost Analysis; Evaluation Studies as Topic; Female; Hu

1973
Similarities between pyruvate kinase from human placenta and tumours.
    FEBS letters, 1973, Dec-01, Volume: 37, Issue:2

    Topics: Adenosine Triphosphate; Alanine; Carcinoma; Chromatography, Gel; Chromatography, Ion Exchange; Elect

1973
Subacute necrotising encephalomyelopathy in three siblings.
    Developmental medicine and child neurology, 1974, Volume: 16, Issue:1

    Topics: Age Factors; Alanine; Brain; Brain Stem; Child, Preschool; Encephalomalacia; Female; Gluconeogenesis

1974
Renal metabolism of amino acids and ammonia in fed and fasted pregnant sheep.
    The American journal of physiology, 1974, Volume: 226, Issue:4

    Topics: Acidosis; Alanine; Amino Acids; Ammonia; Animals; Arginine; Aspartic Acid; Catheterization; Citrulli

1974
Placental amino acid uptake. II. Tissue preincubation, fluid distribution, and mechanisms of regulation.
    Pediatric research, 1974, Volume: 8, Issue:7

    Topics: Aerobiosis; Alanine; Amino Acids; Aminobutyrates; Biological Transport; Carbon Radioisotopes; Cultur

1974
Increased gluconeogenic substrates in the small-for-gestational-age infant.
    The New England journal of medicine, 1974, Aug-15, Volume: 291, Issue:7

    Topics: Acetoacetates; Adolescent; Adult; Age Factors; Alanine; Amino Acids; Birth Weight; Blood Glucose; Ci

1974
Gluconeogenesis and hepatic glycogen formation in relation to the rat estrous cycle.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1974, Volume: 6, Issue:3

    Topics: Alanine; Animals; Blood Glucose; Carbon Radioisotopes; Estrus; Female; Gluconeogenesis; Gonadal Ster

1974
Amino acid metabolism during starvation in human pregnancy.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:5

    Topics: Adolescent; Adult; Alanine; Amino Acids; Aminobutyrates; Amniotic Fluid; Blood Glucose; Female; Food

1972
Influence of cortisol on glycogen synthesis and gluconeogenesis in fetal rat liver in organ culture.
    The Journal of biological chemistry, 1972, Jun-10, Volume: 247, Issue:11

    Topics: Alanine; Animals; Carbon Isotopes; Carboxy-Lyases; Culture Media; Female; Gluconeogenesis; Glucose;

1972
Concentration gradients of amino acids between the uterine and blastocoelic fluid in the rabbit.
    Fertility and sterility, 1972, Volume: 23, Issue:6

    Topics: Alanine; Amino Acids; Animals; Arginine; Asparagine; Aspartic Acid; Body Fluids; Female; Glutamates;

1972
Effects of dietary vitamin B 6 on the utilization of monosodium glutamate by rats.
    The Journal of nutrition, 1972, Volume: 102, Issue:7

    Topics: Aging; Alanine; Alanine Transaminase; Animals; Animals, Newborn; Aspartate Aminotransferases; Aspart

1972
The aminoaciduria of pregnancy.
    The Journal of obstetrics and gynaecology of the British Commonwealth, 1972, Volume: 79, Issue:5

    Topics: Alanine; Amino Acids; Female; Folic Acid; Glycine; Histidine; Humans; Kidney; Pregnancy; Renal Amino

1972
Amino acids in amniotic fluid: changes in concentrations during the first half of pregnancy.
    Pediatric research, 1972, Volume: 6, Issue:8

    Topics: Abortion, Therapeutic; Adult; Alanine; Amino Acids; Amniotic Fluid; Arginine; Chromatography, Ion Ex

1972
Monosodium glutamate: effect of plasma and breast milk amino acid levels in lactating women.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 140, Issue:3

    Topics: Alanine; Amino Acids; Aspartic Acid; Female; Food Additives; Glutamates; Glutamine; Humans; Lactatio

1972
Endocrine control of free amino acids content in uterine fluid in pregnant rabbits.
    Acta endocrinologica, 1972, Volume: 70, Issue:2

    Topics: Alanine; Amino Acids; Ammonia; Animals; Aspartic Acid; Body Fluids; Castration; Corpus Luteum; Embry

1972
Haemoglobin Denmark Hill 95 (G2) Pro-Ala, a variant with unusual electrophoretic and oxygen-binding properties.
    Biochimica et biophysica acta, 1972, Oct-31, Volume: 278, Issue:3

    Topics: Adult; Alanine; Amino Acid Sequence; Amino Acids; Electrophoresis, Paper; Electrophoresis, Starch Ge

1972
[Beef brain alkaline phosphatase: role of magnesium on the action of L-phenylalanine and other amino acids].
    Biochimica et biophysica acta, 1971, Apr-14, Volume: 235, Issue:1

    Topics: Alanine; Alkaline Phosphatase; Amino Acids; Aminocaproates; Animals; Binding Sites; Brain; Cattle; C

1971
Quantitative amino acids in amniotic fluid and maternal plasma in early and late pregnancy. Preliminary report.
    American journal of obstetrics and gynecology, 1971, Sep-15, Volume: 111, Issue:2

    Topics: Alanine; Amino Acids; Aminobutyrates; Amniotic Fluid; Arginine; Aspartic Acid; Citrulline; Cystine;

1971
Developmental changes in Na + , K + and ATP and in the levels and transport of amino acids in incubated slices of rat brain.
    Journal of neurochemistry, 1971, Volume: 18, Issue:6

    Topics: Adenosine Triphosphate; Age Factors; Alanine; Amino Acids; Aminobutyrates; Animals; Animals, Newborn

1971
SH (Australia) antigen in early life.
    Archives of disease in childhood, 1971, Volume: 46, Issue:249

    Topics: Adult; Agglutination; Alanine; Alanine Transaminase; Antibodies; Bilirubin; Blood Protein Electropho

1971
The subunit structure of human placental 17 -estradiol dehydrogenase.
    Biochemical and biophysical research communications, 1971, Aug-20, Volume: 44, Issue:4

    Topics: Acrylamides; Alanine; Alcohol Oxidoreductases; Detergents; Electrophoresis; Electrophoresis, Disc; E

1971
Carbohydrate metabolism in pregnancy. IX. Plasma levels of gluconeogenic fuels during fasting in the rat.
    The Journal of clinical endocrinology and metabolism, 1971, Volume: 33, Issue:5

    Topics: Alanine; Amino Acids; Animals; Carbohydrate Metabolism; Fasting; Female; Gluconeogenesis; Glutamates

1971
Permeability of lung capillaries and alveoli to non-electrolytes in the foetal lamb.
    The Journal of physiology, 1971, Volume: 219, Issue:2

    Topics: Alanine; Amino Acids; Animals; Capillary Permeability; Carbohydrate Metabolism; Erythritol; Female;

1971
Amino acid transport and mental retardation.
    Clinical chemistry, 1971, Volume: 17, Issue:11

    Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Benzyl Compounds; Biological Tr

1971
Alpha-aceto-gamma-hydroxybutyramide--a new antimetabolite.
    Biochemical pharmacology, 1965, Volume: 14, Issue:12

    Topics: Alanine; Amides; Animals; Antimetabolites; Escherichia coli; Female; Fetus; Glutamates; Glutamine; M

1965
The human placental amino acid naphthylamidases; their molecular interrelations and correlations with perinatal factors.
    Human heredity, 1969, Volume: 19, Issue:3

    Topics: Abortion, Spontaneous; Alanine; Aminopeptidases; Arginine; Birth Order; Birth Weight; Centrifugation

1969
Brucella organisms isolated from dogs: comparison of characteristics of members of the genus Brucella.
    American journal of veterinary research, 1969, Volume: 30, Issue:10

    Topics: Abortion, Veterinary; Alanine; Animals; Arabinose; Arginine; Asparagine; Brucella; Brucellosis; Citr

1969
[On the influence of contraceptive pills on serum amino acids in comparison with results typical for sex, menstrual cycle and pregnancy].
    Archiv fur Gynakologie, 1969, Volume: 208, Issue:1

    Topics: Adult; Alanine; Amino Acids; Citric Acid Cycle; Contraceptives, Oral; Female; Glycine; Humans; Isole

1969
Incorporation of labeled nucleic acid and protein precursors by diapausing and nondiapausing blastocysts.
    Biology of reproduction, 1969, Volume: 1, Issue:1

    Topics: Alanine; Animals; Autoradiography; Caniformia; Carbon Isotopes; Dactinomycin; DNA; Embryo Implantati

1969
A procedure for isolating transfer ribonucleic acid from human placenta.
    Biochimica et biophysica acta, 1970, Feb-18, Volume: 199, Issue:2

    Topics: Alanine; Amino Acids; Carbon Isotopes; Carbonates; Female; Humans; Ligases; Methods; Placenta; Pregn

1970
The venous plasma free amino acid levels during the first hours of life. I. After normal and short gestation and gestation complicated by hypertension, with special reference to the "small for dates" syndrome.
    Acta paediatrica Scandinavica, 1970, Volume: 59, Issue:1

    Topics: Alanine; Amino Acids; Arginine; Birth Weight; Blood Glucose; Body Height; Chromatography, Ion Exchan

1970
Quantitative cation-exchange chromatographic analysis of free amino acids in human amniotic fluid collected during early pregnancy.
    Clinical chemistry, 1970, Volume: 16, Issue:11

    Topics: Alanine; Amino Acids; Amino Alcohols; Aminobutyrates; Amniotic Fluid; Autoanalysis; Chromatography,

1970
Influence of pregnancy and-or exercise on intestinal transport of amino acids in rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1970, Volume: 135, Issue:1

    Topics: Adrenal Glands; Alanine; Amino Acids; Animals; Body Weight; Carbon Isotopes; Digestive System Physio

1970
Effect of sex and pregnancy on formation of urea and ammonia during gluconeogenesis in the perfused rat liver.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1970, Volume: 2, Issue:6

    Topics: Alanine; Ammonia; Animals; DNA; Female; Gluconeogenesis; Liver; Male; Nitrogen; Perfusion; Pregnancy

1970
[Functional and structural peculiarities of transfer RNA in protein biosynthesis in some physiological states in animals].
    Ukrains'kyi biokhimichnyi zhurnal, 1970, Volume: 42, Issue:2

    Topics: Alanine; Amino Acids; Animals; Caseins; Chromatography; Fasting; Female; Glycine; Hibernation; Lacta

1970
Gas chromatograph-mass spectrometer-computer system for detection and indentification of abnormal metabolic products in physiological fluids.
    Clinical chemistry, 1971, Volume: 17, Issue:8

    Topics: Alanine; Amniotic Fluid; Blood Chemical Analysis; Cerebrospinal Fluid; Child; Chromatography, Gas; C

1971
[Demonstration and determination of earnosinase activity of the human placenta].
    Enzymologia, 1971, Mar-31, Volume: 40, Issue:3

    Topics: Alanine; Chromatography, Paper; Chromatography, Thin Layer; Dipeptidases; Dipeptides; Electrophoresi

1971
The free amino acid concentrations in maternal and foetal plasmas in the pregnant ewe.
    The Journal of physiology, 1971, Volume: 215, Issue:1

    Topics: Alanine; Amino Acids; Animals; Chromatography, Ion Exchange; Female; Fetus; Glycine; Maternal-Fetal

1971
The distribution of amino acids between erythrocytes and plasma in fetal and maternal blood.
    Clinica chimica acta; international journal of clinical chemistry, 1968, Volume: 20, Issue:1

    Topics: Alanine; Amino Acids; Biological Transport, Active; Chromatography, Paper; Erythrocytes; Female; Glu

1968
Amino acid transport in adult diaphyseal bone: contrast with amino acid transport mechanisms in fetal membranous bone.
    Biochimica et biophysica acta, 1969, Jun-03, Volume: 183, Issue:1

    Topics: Age Factors; Alanine; Amides; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Bon

1969
Development of structure and function in the mammalian yolk sac. 3. The development of amino acid transport by rabbit yolk sac.
    Developmental biology, 1966, Volume: 13, Issue:3

    Topics: Alanine; Amino Acids; Animals; Betaine; Biological Transport; Carbon Isotopes; Female; Fetus; Glycin

1966