alanine has been researched along with Pancreatic Neoplasms in 32 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preclinical trials of a mouse model of pancreatic neuroendocrine tumors (PNET) were conducted to determine whether dual FGF/VEGF pathway inhibition with brivanib can improve first-line efficacy in comparison with VEGF inhibitors lacking fibroblast growth factor (FGF)-inhibitory activity and to characterize second-line brivanib activity before and after the onset of evasive resistance to VEGF-selective therapy." | 7.77 | Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition. ( Allen, E; Hanahan, D; Walters, IB, 2011) |
| "A case of glucagonoma syndrome with necrolytic migratory erythema, glossitis, anemia, hyperglucagonemia and a malignant, pancreatic A-cell tumour in a 68-year-old male is described." | 7.66 | Metabolic studies and glucagon gel filtration pattern before and after surgery in a case of glucagonoma syndrome. ( Berg, J; Bojs, G; Dymling, JF; Hallengren, B; Ljungberg, O; Thorell, JI; Tibblin, S; von Schenck, H, 1979) |
| "In 22 patients with chronic pancreatitis and 16 patients with pancreas neoplasms gamma-glutamyltranspeptidase (GGTP) and alanine arylamidase (AAP) in serum were measured and the isoenzymes were determined by gel electrophoresis on Agar." | 7.65 | [Isoenzymes of alanine arylamidase (AAP, EC 3.4.11.2) and gamma-glutamyltranspeptidase (GGTP, EC 2.3.2.2) in chronic pancreatitis and pancreas neoplasm (author's transl)]. ( Bornschein, W, 1975) |
| "Preclinical trials of a mouse model of pancreatic neuroendocrine tumors (PNET) were conducted to determine whether dual FGF/VEGF pathway inhibition with brivanib can improve first-line efficacy in comparison with VEGF inhibitors lacking fibroblast growth factor (FGF)-inhibitory activity and to characterize second-line brivanib activity before and after the onset of evasive resistance to VEGF-selective therapy." | 3.77 | Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition. ( Allen, E; Hanahan, D; Walters, IB, 2011) |
| "In order to study the role of arachidonic acid (AA) in depolarization-induced insulin secretion rat insulinoma cells (RINm5F) were depleted of AA by cultivation in essential fatty acid-free medium." | 3.68 | Insulin secretion without the participation of arachidonic acid. ( Ammon, HP; Koopmann, I; Safayhi, H, 1993) |
| "To determine the mechanism by which hyperinsulinemia causes hypoglycemia in insulinoma patients, rates of glucose production and utilization, and circulating levels of insulin, glucagon, alanine, lactate, and glycerol were measured in 6 insulinoma patients during development of fasting hypoglycemia and in 8 normal volunteers studied over an identical interval." | 3.66 | Pathogenesis of hypoglycemia in insulinoma patients: suppression of hepatic glucose production by insulin. ( Gerich, JE; Haymond, MW; Mandarino, LJ; Miles, JM; Rizza, RA; Service, FJ; Verdonk, CA, 1981) |
| "A case of glucagonoma syndrome with necrolytic migratory erythema, glossitis, anemia, hyperglucagonemia and a malignant, pancreatic A-cell tumour in a 68-year-old male is described." | 3.66 | Metabolic studies and glucagon gel filtration pattern before and after surgery in a case of glucagonoma syndrome. ( Berg, J; Bojs, G; Dymling, JF; Hallengren, B; Ljungberg, O; Thorell, JI; Tibblin, S; von Schenck, H, 1979) |
| "In 22 patients with chronic pancreatitis and 16 patients with pancreas neoplasms gamma-glutamyltranspeptidase (GGTP) and alanine arylamidase (AAP) in serum were measured and the isoenzymes were determined by gel electrophoresis on Agar." | 3.65 | [Isoenzymes of alanine arylamidase (AAP, EC 3.4.11.2) and gamma-glutamyltranspeptidase (GGTP, EC 2.3.2.2) in chronic pancreatitis and pancreas neoplasm (author's transl)]. ( Bornschein, W, 1975) |
| "However, therapeutic drugs for pancreatic cancer have presented a serious shortage over the past few decades." | 1.62 | The natural product trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer. ( Chen, H; Chen, ZF; Gao, JM; He, QR; Li, D; Liu, Y; Liu, YX; Tang, JJ; Yi, ZF, 2021) |
| "The incidence of pancreatic cancer (PC) continues to increase in the world, while most patients are diagnosed with advanced stages and survive <12 months." | 1.42 | A Novel Multivariate Index for Pancreatic Cancer Detection Based On the Plasma Free Amino Acid Profile. ( Fukutake, N; Hiraoka, N; Imaizumi, A; Ito, T; Katayama, K; Kikuchi, S; Ono, N; Saruki, N; Shimada, K; Shiraishi, K; Ueno, M; Yamakado, M; Yamamoto, H, 2015) |
| "We report a multiple endocrine neoplasia type 1 (MEN1) patient associated with carcinoid syndrome." | 1.32 | A novel missense mutation of the MEN1 gene in a multiple endocrine neoplasia type 1 patient associated with carcinoid syndrome. ( Nishikawa, M; Shigeta, H; Tanaka, T; Ukita, C; Yamaguchi, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (46.88) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 5 (15.63) | 24.3611 |
| 2020's | 4 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Roa, PE | 1 |
| Bazzi, R | 1 |
| Wang, W | 1 |
| Pan, H | 1 |
| Ren, F | 1 |
| Chen, H | 2 |
| Ren, P | 1 |
| Fidan, E | 1 |
| Yildirim, A | 1 |
| Kazaz, N | 1 |
| Fidan, S | 1 |
| Cekic, AB | 1 |
| He, QR | 1 |
| Tang, JJ | 1 |
| Liu, Y | 1 |
| Chen, ZF | 1 |
| Liu, YX | 1 |
| Li, D | 1 |
| Yi, ZF | 1 |
| Gao, JM | 1 |
| Fukutake, N | 1 |
| Ueno, M | 1 |
| Hiraoka, N | 1 |
| Shimada, K | 1 |
| Shiraishi, K | 1 |
| Saruki, N | 1 |
| Ito, T | 1 |
| Yamakado, M | 1 |
| Ono, N | 1 |
| Imaizumi, A | 1 |
| Kikuchi, S | 1 |
| Yamamoto, H | 1 |
| Katayama, K | 1 |
| Sousa, CM | 1 |
| Biancur, DE | 1 |
| Wang, X | 1 |
| Halbrook, CJ | 1 |
| Sherman, MH | 1 |
| Zhang, L | 1 |
| Kremer, D | 1 |
| Hwang, RF | 1 |
| Witkiewicz, AK | 1 |
| Ying, H | 1 |
| Asara, JM | 1 |
| Evans, RM | 1 |
| Cantley, LC | 1 |
| Lyssiotis, CA | 1 |
| Kimmelman, AC | 1 |
| Allen, E | 1 |
| Walters, IB | 1 |
| Hanahan, D | 1 |
| Yao, JC | 1 |
| Phan, A | 1 |
| Yu, R | 1 |
| Chen, CR | 1 |
| Liu, X | 1 |
| Kodra, JT | 1 |
| Ukita, C | 1 |
| Yamaguchi, M | 1 |
| Tanaka, T | 1 |
| Shigeta, H | 1 |
| Nishikawa, M | 1 |
| Hollestelle, MJ | 1 |
| Timmerman, P | 1 |
| Meloen, RH | 1 |
| Höppener, JW | 1 |
| Lowry, SF | 1 |
| Burt, ME | 1 |
| Brennan, MF | 1 |
| Rizza, RA | 1 |
| Haymond, MW | 1 |
| Verdonk, CA | 1 |
| Mandarino, LJ | 1 |
| Miles, JM | 1 |
| Service, FJ | 1 |
| Gerich, JE | 1 |
| Aynsley-Green, A | 1 |
| Jenkins, P | 1 |
| Tronier, B | 1 |
| Heding, LG | 1 |
| Finkelstein, SD | 1 |
| Przygodzki, R | 1 |
| Pricolo, VE | 1 |
| Sayegh, R | 1 |
| Bakker, A | 1 |
| Swalsky, PA | 1 |
| Keller, G | 1 |
| Fanelli, C | 1 |
| Di Vincenzo, A | 1 |
| Modarelli, F | 1 |
| Lepore, M | 1 |
| Ciofetta, M | 1 |
| Epifano, L | 1 |
| Pampanelli, S | 1 |
| Brunetti, P | 1 |
| Bolli, GB | 1 |
| Safayhi, H | 1 |
| Koopmann, I | 1 |
| Ammon, HP | 1 |
| Bode, HP | 1 |
| Weber, S | 1 |
| Fehmann, HC | 1 |
| Göke, B | 1 |
| von Schenck, H | 1 |
| Thorell, JI | 1 |
| Berg, J | 1 |
| Bojs, G | 1 |
| Dymling, JF | 1 |
| Hallengren, B | 1 |
| Ljungberg, O | 1 |
| Tibblin, S | 1 |
| Bornschein, W | 2 |
| Dunne, MJ | 1 |
| Yule, DI | 1 |
| Gallacher, DV | 1 |
| Petersen, OH | 1 |
| Shindo-Okada, N | 1 |
| Makabe, O | 1 |
| Nagahara, H | 1 |
| Nishimura, S | 1 |
| Hale, PJ | 1 |
| Nattrass, M | 1 |
| Boden, G | 1 |
| Ryan, IG | 1 |
| Eisenschmid, BL | 1 |
| Shelmet, JJ | 1 |
| Owen, OE | 1 |
| Sweeny, DJ | 1 |
| Barnes, S | 1 |
| Heggie, GD | 1 |
| Diasio, RB | 1 |
| Del Prato, S | 1 |
| Vigili de Kreutzenberg, S | 1 |
| Trevisan, R | 1 |
| Duner, E | 1 |
| Avogaro, A | 1 |
| Nosadini, R | 1 |
| Baccaglini, U | 1 |
| Tremolada, C | 1 |
| Tiengo, A | 1 |
| Baruh, S | 1 |
| Sherman, L | 1 |
| Kolodny, HD | 1 |
| Singh, AJ | 1 |
| Burchardt, U | 1 |
| Mampel, E | 1 |
| Leithäuser, W | 1 |
| Rohde, L | 1 |
| Rehpenning, W | 1 |
| Hauzeur, F | 1 |
| Schoenemann, J | 1 |
| Kierulf, P | 1 |
| Godal, HC | 1 |
| Oomen, HA | 1 |
| Verleur, H | 1 |
| Lütjens, A | 1 |
1 review available for alanine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Fasting hypoglycemia.
Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenocorticotropic Hormone; Ad | 1973 |
31 other studies available for alanine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Crushed bictegravir/emtricitabine/tenofovir alafenamide in a human immunodeficiency virus-positive patient with pancreatic cancer.
Topics: Adenine; Aged; Alanine; Amides; Anti-HIV Agents; Emtricitabine; Heterocyclic Compounds, 3-Ring; HIV; | 2022 |
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System ASC; Apoptosis; Cell Line, Tumor; Cell | 2022 |
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System ASC; Apoptosis; Cell Line, Tumor; Cell | 2022 |
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System ASC; Apoptosis; Cell Line, Tumor; Cell | 2022 |
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System ASC; Apoptosis; Cell Line, Tumor; Cell | 2022 |
The relationship between albumin-bilirubin score and survival in patients operated for pancreatic cancer.
Topics: Aged; Alanine; Aspartate Aminotransferases; Bilirubin; Carbohydrates; Carcinoembryonic Antigen; Fema | 2022 |
The relationship between albumin-bilirubin score and survival in patients operated for pancreatic cancer.
Topics: Aged; Alanine; Aspartate Aminotransferases; Bilirubin; Carbohydrates; Carcinoembryonic Antigen; Fema | 2022 |
The relationship between albumin-bilirubin score and survival in patients operated for pancreatic cancer.
Topics: Aged; Alanine; Aspartate Aminotransferases; Bilirubin; Carbohydrates; Carcinoembryonic Antigen; Fema | 2022 |
The relationship between albumin-bilirubin score and survival in patients operated for pancreatic cancer.
Topics: Aged; Alanine; Aspartate Aminotransferases; Bilirubin; Carbohydrates; Carcinoembryonic Antigen; Fema | 2022 |
The natural product trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer.
Topics: Alanine; Animals; Apoptosis; Biological Products; Cell Line, Tumor; Cell Proliferation; Mice; Molecu | 2021 |
A Novel Multivariate Index for Pancreatic Cancer Detection Based On the Plasma Free Amino Acid Profile.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Amino Acids; Area Under Curve; Asparagine; Body Mass Index; | 2015 |
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
Topics: Adenocarcinoma; Alanine; Animals; Autophagy; Biosynthetic Pathways; Carbon; Carcinoma, Pancreatic Du | 2016 |
Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition.
Topics: Alanine; Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Benzenesul | 2011 |
Overcoming antiangiogenic resistance.
Topics: Alanine; Animals; Humans; Neuroendocrine Tumors; Pancreatic Neoplasms; Triazines | 2011 |
Rescue of a pathogenic mutant human glucagon receptor by pharmacological chaperones.
Topics: Alanine; Asparagine; Cell Membrane; Curcumin; Cyclic AMP; Drug Design; Glucagon; Green Fluorescent P | 2012 |
A novel missense mutation of the MEN1 gene in a multiple endocrine neoplasia type 1 patient associated with carcinoid syndrome.
Topics: Alanine; Carcinoid Tumor; DNA Mutational Analysis; Duodenal Neoplasms; Female; Fluorescence; Humans; | 2003 |
Characterization of gastrin-cholecystokinin 2 receptor interaction in relation to c-fos induction.
Topics: Alanine; Amino Acid Substitution; Animals; Cell Proliferation; Colorectal Neoplasms; DNA Primers; Ga | 2008 |
Glucose turnover and gluconeogenesis in a patient with somatostatinoma.
Topics: Adenoma, Islet Cell; Alanine; Gluconeogenesis; Glucose; Glucose Tolerance Test; Humans; Hyperglycemi | 1981 |
Pathogenesis of hypoglycemia in insulinoma patients: suppression of hepatic glucose production by insulin.
Topics: Adenoma, Islet Cell; Adult; Aged; Alanine; Blood Glucose; Female; Glucagon; Glucose; Glycerol; Human | 1981 |
Plasma proinsulin and C-peptide concentrations in children with hyperinsulinaemic hypoglycaemia.
Topics: Alanine; C-Peptide; Child; Female; Humans; Hypoglycemia; Infant, Newborn; Insulin; Insulinoma; Lacta | 1984 |
K-ras-2 topographic genotyping of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Alanine; Arginine; Aspartic Acid; Codon; Cysteine; DNA, Neoplasm; Exons; Forecasting | 1994 |
Post-hypoglycaemic hyperketonaemia does not contribute to brain metabolism during insulin-induced hypoglycaemia in humans.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Brain; Cognition; Diabetes Mellitus, Type 1; Female; Glycerol | 1993 |
Insulin secretion without the participation of arachidonic acid.
Topics: Alanine; Animals; Arachidonic Acid; Calcimycin; Calcium; Cell Division; Insulin; Insulin Secretion; | 1993 |
A nutrient-regulated cytosolic calcium oscillator in endocrine pancreatic glucagon-secreting cells.
Topics: Alanine; Animals; Calcium; Carbachol; Cricetinae; Cytosol; Energy Metabolism; Glucagon; Glucagonoma; | 1999 |
Metabolic studies and glucagon gel filtration pattern before and after surgery in a case of glucagonoma syndrome.
Topics: Adenoma, Islet Cell; Aged; Alanine; Anemia; Arginine; Chromatography, Gel; Erythema; Glossitis; Gluc | 1979 |
[Isoenzymes of alanine arylamidase (AAP, EC 3.4.11.2) and gamma-glutamyltranspeptidase (GGTP, EC 2.3.2.2) in chronic pancreatitis and pancreas neoplasm (author's transl)].
Topics: Alanine; Alkaline Phosphatase; Aminopeptidases; Cholestasis; Chronic Disease; Electrophoresis, Agar | 1975 |
[Isoenzymes of alaninarylamidase and gamma-glutamyl-transpeptidase in intrahepatic and extra-hepatic cholostasis (author's transl)].
Topics: Alanine; Bile Duct Neoplasms; Cholestasis; Diagnosis, Differential; Electrophoresis, Agar Gel; gamma | 1975 |
Effects of alanine on insulin-secreting cells: patch-clamp and single cell intracellular Ca2+ measurements.
Topics: Alanine; Animals; Calcium; Cell Membrane; Glucose; Insulin; Insulin Secretion; Insulinoma; Kinetics; | 1990 |
Permanent conversion of NIH3T3 cells transformed by activated c-Ha-ras, c-Ki-ras, N-ras, or c-raf, and of human pancreatic adenocarcinoma containing activated c-Ki-ras to apparently normal cells by treatment with the antibiotic azatyrosine.
Topics: Adenocarcinoma; Alanine; Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line, Transformed | 1990 |
Metabolic profiles in patients with insulinoma.
Topics: Adenoma, Islet Cell; Adult; Aged; Alanine; Blood Glucose; Fatty Acids, Nonesterified; Female; Glycer | 1989 |
Treatment of inoperable glucagonoma with the long-acting somatostatin analogue SMS 201-995.
Topics: Adenoma, Islet Cell; Alanine; Body Weight; Dermatitis; Glucagon; Glucagonoma; Humans; Male; Middle A | 1986 |
Metabolism of 5-fluorouracil to an N-cholyl-2-fluoro-beta-alanine conjugate: previously unrecognized role for bile acids in drug conjugation.
Topics: Alanine; beta-Alanine; Bile Acids and Salts; Cholic Acids; Chromatography, High Pressure Liquid; Flu | 1987 |
Hyperalaninaemia is an early feature of diabetes secondary to total pancreatectomy.
Topics: Adenocarcinoma; Adult; Aged; Alanine; C-Peptide; Diabetes Mellitus, Type 1; Female; Glucagon; Humans | 1985 |
[Behavior of alanine aminopeptidase excretion after administration of Visotrast as diagnostic means].
Topics: Alanine; Aminopeptidases; Cholangitis; Cholelithiasis; Contrast Media; Hodgkin Disease; Humans; Kidn | 1974 |
[Critical studies on the diagnostic significance of alanine aminopeptidase and its isoenzymes in pancreatic diseases].
Topics: Adolescent; Adult; Alanine; Alkaline Phosphatase; Aminopeptidases; Amylases; Cholestasis; Clinical E | 1972 |
Fibrinaemia and multiple thrombi in pancreatic carcinoma. A case studied with quantitative N-terminal analysis.
Topics: Alanine; Blood Coagulation; Blood Coagulation Tests; Disseminated Intravascular Coagulation; Fibrin; | 1972 |
[The value of fractionated alanine-amino-peptidase-(ANAase) study in pancreatic disorders].
Topics: Alanine; Diagnosis, Differential; Female; Humans; Male; Pancreatic Diseases; Pancreatic Neoplasms; P | 1971 |