alanine has been researched along with Oxaluria, Primary in 15 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The rare disease Primary Hyperoxaluria Type I (PH1) results from the deficit of liver peroxisomal alanine:glyoxylate aminotransferase (AGT), as a consequence of inherited mutations on the AGXT gene frequently leading to protein misfolding." | 1.42 | The Chaperoning Activity of Amino-oxyacetic Acid on Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I. ( Cellini, B; Chellini, S; Dindo, M; Lorenzetto, A; Maccari, L; Montioli, R; Oppici, E; Porcari, V; Voltattorni, CB, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Assimos, DG | 3 |
| Wood, KD | 1 |
| Freeman, BL | 1 |
| Killian, ME | 1 |
| Lai, WS | 1 |
| Assimos, D | 1 |
| Knight, J | 1 |
| Fargue, S | 2 |
| Oppici, E | 4 |
| Fodor, K | 1 |
| Paiardini, A | 2 |
| Williams, C | 1 |
| Voltattorni, CB | 3 |
| Wilmanns, M | 1 |
| Cellini, B | 4 |
| Montioli, R | 3 |
| Dindo, M | 1 |
| Maccari, L | 1 |
| Porcari, V | 1 |
| Lorenzetto, A | 2 |
| Chellini, S | 1 |
| Pagliarini, R | 1 |
| Castello, R | 1 |
| Napolitano, F | 1 |
| Borzone, R | 1 |
| Annunziata, P | 1 |
| Mandrile, G | 1 |
| De Marchi, M | 1 |
| Brunetti-Pierri, N | 1 |
| di Bernardo, D | 1 |
| Maset, F | 1 |
| Bellini, T | 1 |
| Lewin, J | 1 |
| Rumsby, G | 1 |
| Danpure, CJ | 3 |
| Horváth, VA | 1 |
| Wanders, RJ | 1 |
| Purdue, PE | 2 |
| Fryer, P | 1 |
| Griffiths, S | 1 |
| Allsop, J | 2 |
| Lumb, MJ | 2 |
| Guttridge, KM | 1 |
| Jennings, PR | 1 |
| Scheinman, JI | 1 |
| Mauer, SM | 1 |
| Calzavara, P | 1 |
| Marangella, M | 1 |
| Petrarulo, M | 1 |
| Ballanti, P | 1 |
| Bonucci, E | 1 |
| Calconi, G | 1 |
| Maresca, MC | 1 |
| da Porto, A | 1 |
| Vianello, A | 1 |
| Furby, A | 1 |
| Mourtada, R | 1 |
| Charasse, C | 1 |
| Rivalan, J | 1 |
| Messner, M | 1 |
| Leroy, JP | 1 |
| Minatogawa, Y | 1 |
1 review available for alanine and Oxaluria, Primary
| Article | Year |
|---|---|
Liver peroxisomal alanine:glyoxylate aminotransferase and the effects of mutations associated with Primary Hyperoxaluria Type I: An overview.
Topics: Alanine; Humans; Hyperoxaluria, Primary; Liver; Mutation; Peroxisomes; Transaminases | 2015 |
14 other studies available for alanine and Oxaluria, Primary
| Article | Year |
|---|---|
Re: Cycloserine Enantiomers are Reversible Inhibitors of Human Alanine:Glyoxylate Aminotransferase: Implications for Primary Hyperoxaluria Type 1.
Topics: Alanine; Cycloserine; Humans; Hyperoxaluria, Primary; Transaminases | 2020 |
Effect of alanine supplementation on oxalate synthesis.
Topics: Alanine; Alcohol Oxidoreductases; Animals; CHO Cells; Cricetulus; Hyperoxaluria, Primary; Mice; Mice | 2021 |
Re: Use of Polymer Conjugates for the Intraperoxisomal Delivery of Engineered Humanalanine:Glyoxylate Aminotransferase as a Protein Therapy for Primary Hyperoxaluria Type I.
Topics: Alanine; Alanine Transaminase; Humans; Hyperoxaluria, Primary; Polymers; Transaminases | 2017 |
Crystal structure of the S187F variant of human liver alanine: glyoxylate [corrected] aminotransferase associated with primary hyperoxaluria type I and its functional implications.
Topics: Alanine; Catalytic Domain; Crystallography, X-Ray; Humans; Hyperoxaluria, Primary; Liver; Models, Mo | 2013 |
The Chaperoning Activity of Amino-oxyacetic Acid on Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I.
Topics: Alanine; Aminooxyacetic Acid; Blotting, Western; Fluorescent Antibody Technique; Genetic Variation; | 2015 |
In Silico Modeling of Liver Metabolism in a Human Disease Reveals a Key Enzyme for Histidine and Histamine Homeostasis.
Topics: Alanine; Alanine Transaminase; Animals; Cell Line; Computer Simulation; Gene Knockdown Techniques; H | 2016 |
Re: Pyridoxamine and Pyridoxal are More Effective than Pyridoxine in Rescuing Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I.
Topics: Alanine; Humans; Hyperoxaluria; Hyperoxaluria, Primary; Pyridoxal; Pyridoxamine; Pyridoxine | 2016 |
Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I.
Topics: Alanine; Chromatography, Gel; Dimerization; Glycine; Humans; Hyperoxaluria, Primary; Kinetics; Mass | 2010 |
Four of the most common mutations in primary hyperoxaluria type 1 unmask the cryptic mitochondrial targeting sequence of alanine:glyoxylate aminotransferase encoded by the polymorphic minor allele.
Topics: Alanine; Alleles; Animals; Cell Line; CHO Cells; Cricetinae; Cricetulus; Dimerization; Humans; Hyper | 2013 |
Re-evaluation of conditions required for measurement of true alanine:glyoxylate aminotransferase activity in human liver: implications for the diagnosis of hyperoxaluria type I.
Topics: Alanine; Alanine Transaminase; Cross Reactions; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; | 1994 |
Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation.
Topics: Adult; Alanine; Amino Acid Sequence; Base Sequence; Cell Compartmentation; Child; DNA Mutational Ana | 1993 |
Long-term survival on renal replacement therapy for primary hyperoxaluria type I.
Topics: Adult; Alanine; Glycolates; Humans; Hyperoxaluria, Primary; Kidney Failure, Chronic; Kidney Transpla | 1993 |
[Polyradiculoneuropathy in an adult with primitive hyperoxaluria].
Topics: Adult; Alanine; Biopsy; Disease Progression; Humans; Hyperoxaluria, Primary; Kidney Failure, Chronic | 2000 |
A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1.
Topics: Alanine; Amino Acid Sequence; Base Sequence; Glutamates; Glutamic Acid; Glycine; Humans; Hyperoxalur | 1992 |