alanine and Obesity studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

Excerpt	Relevance	Reference
"Integrase inhibitors, including dolutegravir (DTG), are associated with weight gain and obesity, especially when combined with tenofovir alafenamide (TAF)."	9.12	The predicted risk of adverse pregnancy outcomes as a result of treatment-associated obesity in a hypothetical population receiving tenofovir alafenamide/emtricitabine/dolutegravir, tenofovir disoproxil fumarate/emtricitabine/dolutegravir or tenofovir dis ( Asif, S; Baxevanidi, E; Chandiwana, N; Fairlie, L; Hill, A; Masenya, M; Serenata, C; Sokhela, S; Venter, WDF, 2021)
"Obesity is associated with altered glycine metabolism in humans."	7.96	Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats. ( Edwards, AK; McKnight, SM; Satterfield, MC; Simmons, RM; Wu, G, 2020)
"L-alanine (Ala) and L-arginine (Arg) have been reported to regulate pancreatic β-cell physiology and to prevent body fat accumulation in diet-induced obesity."	7.85	Benefits of L-alanine or L-arginine supplementation against adiposity and glucose intolerance in monosodium glutamate-induced obesity. ( Araujo, TR; Balbo, SL; Batista, TM; Bonfleur, ML; Boschero, AC; Carneiro, EM; Freitas, IN; Ribeiro, RA; Santos-Silva, JC; Vettorazzi, JF, 2017)
"This study was undertaken to investigate the impact of the Pro12Ala (rs1801282) polymorphism of the peroxisome proliferator-activated receptor gamma-2 (PPARgamma-2) gene on obesity or body mass index (BMI) and plasma leptin, insulin, adiponectin and lipid levels in a sample of the Tunisian population."	7.75	Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. ( Ben Ali, S; Ben Yahia, F; Elasmi, M; Feki, M; Ftouhi, B; Haj-Taieb, S; Jemaa, R; Kaabachi, N; Kallel, A; Sanhagi, H; Sediri, Y; Slimane, H; Souheil, O, 2009)
"Obesity is an important correlate of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels."	7.74	Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham heart study. ( D'Agostino, RB; Ellison, RC; Fox, CS; Hwang, SJ; Liang, TJ; Loomba, R; O'Donnell, CJ; Vasan, RS, 2008)
" We examined the association between Pro12Ala polymorphism of PPARG2, type 2 diabetes mellitus (DM2), and peripheral insulin sensitivity in a population with a high intake of oleic acid."	7.73	Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid. ( Cardona, F; de la Cruz Almaráz, M; Esteva, I; Morcillo, S; Olveira, G; Rojo-Martínez, G; Ruiz de Adana, Mde L; Soriguer, F; Tinahones, F, 2006)
"The relationship between changes in ketone concentrations and leucine metabolism (seven obese subjects), glucose and alanine metabolism (seven obese subjects) was investigated using radioisotopic techniques after 12 h, 60 h and 2 weeks starvation."	7.69	The effect of starvation on leucine, alanine and glucose metabolism in obese subjects. ( Boroujerdi, MA; Scobie, IN; Sönksen, PH; Umpleby, AM, 1995)
"The "in vivo" handling of L-alanine in 24 hours starved rats, in which obesity was induced by feeding with cafeteria diet, was compared with that of starved control rats."	7.68	In vivo C14-L-alanine metabolism in rat dietary obesity induced by cafeteria diet. ( Gianotti, M; Palou, A; Pons, A; Roca, P, 1990)
"Obesity was associated with the level of serum liver enzymes."	5.72	The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transferase in adult women. ( Ajami, M; Alizadeh, A; Doaei, S; Esmaeili, M; Gholamalizadeh, M; Hajipour, A; Hasanpour Ardekanizadeh, N; Houshiarrad, A; Jalili, V; Mokhtari, Z; Poorahmadi, Z; Shafaei, H; Shafie, F, 2022)
"Glycogen levels were also lower in this region."	5.36	Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. ( Benie, AJ; Bouman, SD; Schousboe, A; Sickmann, HM; Waagepetersen, HS, 2010)
"Integrase inhibitors, including dolutegravir (DTG), are associated with weight gain and obesity, especially when combined with tenofovir alafenamide (TAF)."	5.12	The predicted risk of adverse pregnancy outcomes as a result of treatment-associated obesity in a hypothetical population receiving tenofovir alafenamide/emtricitabine/dolutegravir, tenofovir disoproxil fumarate/emtricitabine/dolutegravir or tenofovir dis ( Asif, S; Baxevanidi, E; Chandiwana, N; Fairlie, L; Hill, A; Masenya, M; Serenata, C; Sokhela, S; Venter, WDF, 2021)
"We tested the effect-modifying role of Pro12Ala on the 1 year change in obesity-related traits in a randomised clinical trial of treatment with metformin (n = 989), troglitazone (n = 363) or lifestyle modification (n = 1,004) vs placebo (n = 1,000) for diabetes prevention in high-risk individuals."	5.12	The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program. ( Altshuler, D; Delahanty, L; Florez, JC; Franks, PW; Hanson, RL; Jablonski, KA; Kahn, SE; Knowler, WC, 2007)
"The associations for the following amino acids with HOMA-IR at the 3-year follow-up significantly varied by obesity status: isoleucine, valine, tyrosine, alanine, and methionine (all p for interaction <0."	4.12	Associations of serum amino acids with insulin resistance among people with and without overweight or obesity: A prospective study in Japan. ( Chen, S; Eguchi, M; Fukunaga, A; Kabe, I; Kochi, T; Miki, T; Mizoue, T; Nanri, A, 2022)
"Obesity is associated with altered glycine metabolism in humans."	3.96	Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats. ( Edwards, AK; McKnight, SM; Satterfield, MC; Simmons, RM; Wu, G, 2020)
"L-alanine (Ala) and L-arginine (Arg) have been reported to regulate pancreatic β-cell physiology and to prevent body fat accumulation in diet-induced obesity."	3.85	Benefits of L-alanine or L-arginine supplementation against adiposity and glucose intolerance in monosodium glutamate-induced obesity. ( Araujo, TR; Balbo, SL; Batista, TM; Bonfleur, ML; Boschero, AC; Carneiro, EM; Freitas, IN; Ribeiro, RA; Santos-Silva, JC; Vettorazzi, JF, 2017)
"This study was undertaken to investigate the impact of the Pro12Ala (rs1801282) polymorphism of the peroxisome proliferator-activated receptor gamma-2 (PPARgamma-2) gene on obesity or body mass index (BMI) and plasma leptin, insulin, adiponectin and lipid levels in a sample of the Tunisian population."	3.75	Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. ( Ben Ali, S; Ben Yahia, F; Elasmi, M; Feki, M; Ftouhi, B; Haj-Taieb, S; Jemaa, R; Kaabachi, N; Kallel, A; Sanhagi, H; Sediri, Y; Slimane, H; Souheil, O, 2009)
"Obesity is an important correlate of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels."	3.74	Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham heart study. ( D'Agostino, RB; Ellison, RC; Fox, CS; Hwang, SJ; Liang, TJ; Loomba, R; O'Donnell, CJ; Vasan, RS, 2008)
" We examined the association between Pro12Ala polymorphism of PPARG2, type 2 diabetes mellitus (DM2), and peripheral insulin sensitivity in a population with a high intake of oleic acid."	3.73	Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid. ( Cardona, F; de la Cruz Almaráz, M; Esteva, I; Morcillo, S; Olveira, G; Rojo-Martínez, G; Ruiz de Adana, Mde L; Soriguer, F; Tinahones, F, 2006)
"To determine whether there are variations in leptin levels according to the beta(3)-adrenoceptor (beta(3)-AR) Trp64Arg and uncoupling protein 1 (UCP1) -3826A-->G polymorphisms, given the regulatory role of catecholamines through the beta(3)-AR in leptin production and the previously reported association of the UCP1 -3826A-->G variant with obesity."	3.72	The Arg64 allele of the beta 3-adrenoceptor gene but not the -3826G allele of the uncoupling protein 1 gene is associated with increased leptin levels in the Spanish population. ( Fernández-Pérez, C; González-Sánchez, JL; Martínez-Larrad, MT; Palou, A; Proenza, AM; Ramis, JM; Serrano-Ríos, M, 2004)
" The objective of the current study was to examine the potential impact of a C-->T substitution in exon 4, resulting in an alanine to valine substitution at codon 55, on the Metabolic Syndrome in 284 unrelated Swedish men born in 1944."	3.71	Lack of association between the uncoupling protein-2 Ala55Val gene polymorphism and phenotypic features of the Metabolic Syndrome. ( Björntorp, P; Bouchard, C; Rosmond, R, 2002)
"The relationship between changes in ketone concentrations and leucine metabolism (seven obese subjects), glucose and alanine metabolism (seven obese subjects) was investigated using radioisotopic techniques after 12 h, 60 h and 2 weeks starvation."	3.69	The effect of starvation on leucine, alanine and glucose metabolism in obese subjects. ( Boroujerdi, MA; Scobie, IN; Sönksen, PH; Umpleby, AM, 1995)
"Membrane vesicles from the small intestine brush border were obtained and used to determine the possible effects of genetic or nutritional obesity on L-alanine uptake."	3.69	L-alanine transport in small intestine brush-border membrane vesicles of obese rats. ( Alemany, M; Remesar, X; Sanchís, D, 1994)
"The "in vivo" handling of L-alanine in 24 hours starved rats, in which obesity was induced by feeding with cafeteria diet, was compared with that of starved control rats."	3.68	In vivo C14-L-alanine metabolism in rat dietary obesity induced by cafeteria diet. ( Gianotti, M; Palou, A; Pons, A; Roca, P, 1990)
"To investigate glucagon (IRG) and insulin (IRI) responses to alanine infusion in obesity and to assess the effect of body weight reduction with respect to hormonal balance, we compared six obese subjects with nine normal weight controls."	3.67	Plasma glucagon response to intravenous alanine in obese and non-obese subjects. ( Asano, T; Kan, K; Ninomiya, H; Okumura, M; Yamamoto, T, 1989)
"The methods utilized in our laboratory for a biochemical approach of obesity include dietary manipulations, fatty acid analysis of tissue lipids, in vivo lipogenesis from [3H H2O and [1-14C] acetate, in vitro utilization of [3H] H2O, [U-14C] glucose, [U-14C] fructose, [U-14C] alanine and [1-14C] acetate by adipose tissue fragments, hormone sensitivity (to insulin and catecholamines), and the activity of enzymes such as fatty acid synthetase and adenylate cyclase in adipose tissue extracts."	3.66	Experimental basis of obesity. ( Christophe, J; Dehaye, JP; Winand, J, 1978)
"Plasma concentrations of glucagon, insulin, glucose, and individual plasma amino acids were measured in normal nonobese and obese subjects before and after 3 days of dexamethasone treatment (2 mg/day) and in patients with Cushing's syndrome."	3.65	Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man. ( Felig, P; Hendler, R; Wise, JK, 1973)
"Obesity was negatively associated to clinical improvement after Remdesivir (OR 0."	1.72	The impact of obesity and dyslipidemia on Remdesivir effectiveness in hospitalized patients with SARS-CoV-2-related pneumonia: An observational study. ( Biondi, G; Brugaletta, G; Oliveri, R; Romano, M; Romano, R; San Lio, PM; Scicali, R; Tumminia, A, 2022)
"Rheumatic diseases were IA (60%) and CTD (40%)."	1.56	Clinical outcomes of hospitalised patients with COVID-19 and chronic inflammatory and autoimmune rheumatic diseases: a multicentric matched cohort study. ( Alvaro-Gracia, JM; Blanco, R; Carmona, L; Castrejón, I; Fernández Fernández, D; Fernandez-Nebro, A; Galindo, M; Gonzalez-Gay, MA; Lledó, A; Manrique-Arija, S; Martinez-Lopez, D; Mena Vázquez, N; Mera-Varela, A; Pablos, JL; Retuerto, M, 2020)
"Obesity is associated with increased incidence and worse prognosis of more than one dozen tumor types; however, the molecular mechanisms for this association remain under debate."	1.51	Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation. ( Perry, RJ; Rabin-Court, A; Rodrigues, MR; Zhang, XM, 2019)
"Obesity is for many scholars the most important starting status that gives rise to Metabolic Syndrome (MS) and Type 2 Diabetes (T2D)."	1.39	Amerindians show no association of PPAR-γ2 gene Ala12 allele and obesity: an "unthrifty" variant population genetics. ( Abd-El-Fatah-Khalil, S; Algora, M; Areces, C; Arnaiz-Villena, A; Arribas, I; Coca, C; Enríquez-de-Salamanca, M; Fernández-Honrado, M; Rey, D, 2013)
"Obesity is a major health crisis worldwide and new treatments are needed to fight this epidemic."	1.37	Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle. ( Gu, W; Kong, X; Li, X; Liu, Z; Smith, SB; Tan, B; Tang, W; Wu, G; Xu, H; Yao, K; Yin, Y, 2011)
"Glycogen levels were also lower in this region."	1.36	Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. ( Benie, AJ; Bouman, SD; Schousboe, A; Sickmann, HM; Waagepetersen, HS, 2010)
"Because obesity is one of the most important risk factors for cardiovascular diseases and type 2 diabetes, obese children, who are presumably at a higher risk, may be protected from these diseases by the phenotypic effect of the Ala 12 allele on insulin resistance."	1.33	PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity in childhood obesity. ( Alemanno, I; Buzzetti, R; Caiazzo, AM; Capizzi, M; di Mario, U; Mein, CA; Osborn, JA; Petrone, A; Vania, A; Zavarella, S, 2005)
"Obesity was defined according to International Obesity Task Force."	1.33	PPAR-gamma2 Pro12Ala variant, insulin resistance and plasma long-chain polyunsaturated fatty acids in childhood obesity. ( Agostoni, C; Biondi, ML; Giovannini, M; Radaelli, G; Salvioni, M; Scaglioni, S; Verduci, E, 2006)
"Insulin resistance was estimated through the homeostasis model assessment for insulin resistance method."	1.32	Intestinal FABP2 A54T polymorphism: association with insulin resistance and obesity in women. ( Albala, C; Angel, B; Cifuentes, M; Lera, L; Liberman, C; Pérez-Bravo, F; Santos, JL; Villarroel, AC, 2004)
"+10 mg kg(-1) h(-1)) as pretreatments."	1.31	Acute effect of the dual angiotensin-converting enzyme and neutral endopeptidase 24-11 inhibitor mixanpril on insulin sensitivity in obese Zucker rat. ( Arbin, V; Claperon, N; Fournié-Zaluski, MC; Peyroux, J; Roques, BP, 2001)
"The odds ratio (95% CI) in dyslipidemia of the Thr54 allele was 1."	1.31	No association found between the Ala54Thr polymorphism of FABP2 gene and obesity and obesity with dyslipidemia in Japanese schoolchildren. ( Endo, K; Hamaguchi, H; Hayakawa, Y; Hirano, C; Tomura, S; Yanagi, H, 2001)
" Oral hypoglycaemic agent dosage fell from a median of eight (IQ 6-12) to two (IQ 0-8) tablets per day (P = 0."	1.30	Very low calorie diet (VLCD): a useful alternative in the treatment of the obese NIDDM patient. ( Brooks, BA; Burns, CM; Capstick, F; Steinbeck, KS; Yue, DK; Zilkens, RR, 1997)
"We studied seven obese subjects with type 2 diabetes and seven lean and seven obese control subjects (fasting plasma glucose levels, 7."	1.30	Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. ( Giacca, A; Groenewoud, Y; McClean, P; Tsui, E; Zinman, B, 1998)
"Hyperglycemia in NIDDM compensated for insulin resistance to the extent that rates of glucose metabolism were the same as those for nondiabetics studied at euglycemia."	1.29	Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM. ( Consoli, A; Jain, A; Kelley, DE; Mandarino, LJ, 1996)
"Glycerol was not a major contributor to glyceride-glycerol synthesis (3."	1.26	A comparison of the enzyme levels and the in vitro utilization of various substrates for lipogenesis in pair-fed lean and obese pigs. ( Herbein, JH; Martin, RJ, 1976)

Research

Studies (150)

Authors

Clinical Trials (7)

Trial Overview

Trial Outcomes

Comparison of Changes in Fasting Serum Glucose (FSG)With Pioglitazone and Metformin

Timeframe	Studies, this research(%)	All Research%
pre-1990	50 (33.33)	18.7374
1990's	23 (15.33)	18.2507
2000's	38 (25.33)	29.6817
2010's	18 (12.00)	24.3611
2020's	21 (14.00)	2.80

Authors	Studies
Ayodele, O	1
Ren, K	1
Zhao, J	1
Signorovitch, J	1
Jonsson Funk, M	1
Zhu, J	1
Bao, Y	1
Gondek, K	1
Keenan, H	1
Ye, Z	1
Zhang, C	1
Wang, S	1
Zhang, Y	1
Li, R	1
Zhao, Y	1
Qiao, J	1
Martino, MR	1
Gutiérrez-Aguilar, M	1
Yiew, NKH	1
Lutkewitte, AJ	1
Singer, JM	1
McCommis, KS	1
Ferguson, D	1
Liss, KHH	1
Yoshino, J	1
Renkemeyer, MK	1
Smith, GI	1
Cho, K	1
Fletcher, JA	1
Klein, S	2
Patti, GJ	1
Burgess, SC	1
Finck, BN	1
Tumminia, A	1
Romano, R	1
Brugaletta, G	1
Scicali, R	1
Biondi, G	1
Oliveri, R	1
Romano, M	1
San Lio, PM	1
Atefi, M	1
Entezari, MH	1
Vahedi, H	1
Hassanzadeh, A	1
Chen, S	1
Miki, T	1
Fukunaga, A	1
Eguchi, M	1
Kochi, T	1
Nanri, A	1
Kabe, I	1
Mizoue, T	1
Jalili, V	1
Poorahmadi, Z	1
Hasanpour Ardekanizadeh, N	1
Gholamalizadeh, M	1
Ajami, M	1
Houshiarrad, A	1
Hajipour, A	1
Shafie, F	1
Alizadeh, A	1
Mokhtari, Z	1
Shafaei, H	1
Esmaeili, M	1
Doaei, S	1
He, X	1
Ji, N	1
Huang, X	1
Liu, M	1
Wang, J	1
Sun, T	1
Sise, ME	1
Baggett, MV	1
Shepard, JO	1
Stevens, JS	1
Rhee, EP	1
Azmy, V	1
Benson, J	1
Love, K	1
Steele, R	1
Wang, Y	3
Foo, R	1
Thum, T	1
Téllez, L	1
Martín Mateos, RM	1
Pablos, JL	1
Galindo, M	1
Carmona, L	1
Lledó, A	1
Retuerto, M	1
Blanco, R	1
Gonzalez-Gay, MA	1
Martinez-Lopez, D	1
Castrejón, I	1
Alvaro-Gracia, JM	1
Fernández Fernández, D	1
Mera-Varela, A	1
Manrique-Arija, S	1
Mena Vázquez, N	1
Fernandez-Nebro, A	1
Dellapiana, G	1
Naqvi, M	1
Leggett, C	1
Tholemeier, L	1
Burwick, RM	1
Holeček, M	1
Simmons, RM	1
McKnight, SM	1
Edwards, AK	1
Wu, G	3
Satterfield, MC	1
Fikri, AM	1
Smyth, R	1
Kumar, V	1
Al-Abadla, Z	1
Abusnana, S	1
Munday, MR	1
Surial, B	1
Mugglin, C	1
Calmy, A	1
Cavassini, M	1
Günthard, HF	1
Stöckle, M	1
Bernasconi, E	1
Schmid, P	1
Tarr, PE	1
Furrer, H	1
Ledergerber, B	1
Wandeler, G	1
Rauch, A	1
Okun, JG	1
Rusu, PM	1
Chan, AY	1
Wu, Y	1
Yap, YW	1
Sharkie, T	1
Schumacher, J	1
Schmidt, KV	1
Roberts-Thomson, KM	1
Russell, RD	1
Zota, A	1
Hille, S	1
Jungmann, A	1
Maggi, L	1
Lee, Y	1
Blüher, M	1
Herzig, S	1
Keske, MA	1
Heikenwalder, M	1
Müller, OJ	1
Rose, AJ	1
Asif, S	1
Baxevanidi, E	1
Hill, A	1
Venter, WDF	1
Fairlie, L	1
Masenya, M	1
Serenata, C	1
Sokhela, S	1
Chandiwana, N	1
Adachi, Y	1
De Sousa-Coelho, AL	1
Harata, I	1
Aoun, C	1
Weimer, S	1
Shi, X	1
Gonzalez Herrera, KN	1
Takahashi, H	1
Doherty, C	1
Noguchi, Y	1
Goodyear, LJ	1
Haigis, MC	1
Gerszten, RE	1
Patti, ME	1
Rabin-Court, A	1
Rodrigues, MR	1
Zhang, XM	1
Perry, RJ	1
Choy, K	1
Nash, SH	1
Kristal, AR	1
Hopkins, S	1
Boyer, BB	1
O'Brien, DM	1
de Luis, DA	2
Aller, R	2
Izaola, O	3
Gonzalez Sagrado, M	2
Conde, R	3
Wang, X	1
Liu, J	1
Ouyang, Y	1
Fang, M	1
Gao, H	1
Liu, L	1
Yoshihara, A	1
Sugita, N	1
Iwasaki, M	1
Miyazaki, H	1
Yoshie, H	1
Nakamura, K	1
Araujo, TR	1
Freitas, IN	1
Vettorazzi, JF	1
Batista, TM	1
Santos-Silva, JC	1
Bonfleur, ML	1
Balbo, SL	1
Boschero, AC	1
Carneiro, EM	1
Ribeiro, RA	1
Johansson, LE	1
Danielsson, P	1
Norgren, S	1
Marcus, C	1
Ridderstråle, M	1
Dong, CP	1
He, L	1
Li, JN	1
Ye, F	1
He, M	1
Mirzaei, H	1
Akrami, SM	1
Golmohammadi, T	1
Doosti, M	1
Heshmat, R	1
Nakhjavani, M	1
Amiri, P	1
Ben Ali, S	1
Ben Yahia, F	1
Sediri, Y	1
Kallel, A	1
Ftouhi, B	1
Feki, M	1
Elasmi, M	1
Haj-Taieb, S	1
Souheil, O	1
Sanhagi, H	1
Slimane, H	1
Jemaa, R	1
Kaabachi, N	1
Sickmann, HM	1
Waagepetersen, HS	1
Schousboe, A	1
Benie, AJ	1
Bouman, SD	1
Tan, B	1
Yin, Y	1
Liu, Z	1
Tang, W	1
Xu, H	1
Kong, X	1
Li, X	1
Yao, K	1
Gu, W	1
Smith, SB	1
Ballesteros, M	1
Ruiz, E	1
Cordero, M	1
Muñoz, C	1
Penacho, MA	1
Iglesias, P	1
Lopez Guzman, A	1
Maldonado, A	1
San Martin, L	1
Puigdevall, V	1
Romero, E	1
Chen, CH	1
Lu, ML	1
Kuo, PH	1
Chen, PY	1
Chiu, CC	1
Kao, CF	1
Huang, MC	1
Wang, XS	1
Bai, H	1
Fan, P	1
Liu, R	1
Liu, Y	1
Liu, BW	1
Jermendy, A	1
Körner, A	1
Kovács, M	1
Madácsy, L	1
Cseh, K	1
Bordbar, A	1
Feist, AM	1
Usaite-Black, R	1
Woodcock, J	1
Palsson, BO	1
Famili, I	1
Freudenberg, A	1
Petzke, KJ	1
Klaus, S	1
López-Alarcón, M	1
Rodríguez-Cruz, M	1
Vital-Reyes, VS	1
Zavala-Ortega, MI	1
Hinojosa-Cruz, JC	1
Canizales-Quinteros, S	1
Fernández, J	1
de Luis, D	1
Sagrado, MG	1
de la Fuente, B	1
Primo, D	1
Arnaiz-Villena, A	1
Fernández-Honrado, M	1
Areces, C	1
Enríquez-de-Salamanca, M	1
Abd-El-Fatah-Khalil, S	1
Coca, C	1
Arribas, I	1
Algora, M	1
Rey, D	1
Simón, I	1
Vendrell, J	1
Gutiérrez, C	1
Fernández-Real, JM	1
Vendrell, I	1
Gallart, L	1
Fontova, R	1
Richart, C	1
Rosmond, R	1
Bouchard, C	1
Björntorp, P	1
Arbin, V	2
Claperon, N	2
Fournié-Zaluski, MC	2
Roques, BP	2
Peyroux, J	2
McFadden, JM	1
Frehywot, GL	1
Townsend, CA	1
Gault, VA	1
O'Harte, FP	1
Harriott, P	1
Flatt, PR	1
Rangwala, SM	1
Rhoades, B	1
Shapiro, JS	1
Rich, AS	1
Kim, JK	1
Shulman, GI	1
Kaestner, KH	1
Lazar, MA	1
Masud, S	1
Ye, S	1
Xita, N	1
Tsatsoulis, A	1
Chatzikyriakidou, A	1
Georgiou, I	1
Vieira-Filho, JP	1
Reis, AF	1
Kasamatsu, TS	1
Tavares, EF	1
Franco, LJ	1
Matioli, SR	1
Moisés, RS	1
Albala, C	1
Santos, JL	1
Cifuentes, M	1
Villarroel, AC	1
Lera, L	1
Liberman, C	1
Angel, B	1
Pérez-Bravo, F	1
Wang, C	1
Zhai, F	1
Chi, Y	1
Wang, G	1
D'Adamo, M	1
Perego, L	1
Cardellini, M	1
Marini, MA	1
Frontoni, S	1
Andreozzi, F	1
Sciacqua, A	1
Lauro, D	1
Sbraccia, P	1
Federici, M	1
Paganelli, M	1
Pontiroli, AE	1
Lauro, R	1
Perticone, F	1
Folli, F	1
Sesti, G	1
Bidzińska, B	2
Demissie, M	2
Tworowska, U	2
Slezak, R	2
Dobosz, T	2
Milewicz, A	2
Buzzetti, R	1
Petrone, A	1
Caiazzo, AM	1
Alemanno, I	1
Zavarella, S	1
Capizzi, M	1
Mein, CA	1
Osborn, JA	1
Vania, A	1
di Mario, U	1
Ramis, JM	1
González-Sánchez, JL	1
Proenza, AM	1
Martínez-Larrad, MT	1
Fernández-Pérez, C	1
Palou, A	2
Serrano-Ríos, M	1
Ghoussaini, M	1
Meyre, D	1
Lobbens, S	1
Charpentier, G	1
Clément, K	1
Charles, MA	1
Tauber, M	1
Weill, J	1
Froguel, P	1
Stefański, A	1
Majkowska, L	1
Ciechanowicz, A	1
Frankow, M	1
Safranow, K	1
Parczewski, M	1
Moleda, P	1
Pilarska, K	1
Soriguer, F	1
Morcillo, S	1
Cardona, F	1
Rojo-Martínez, G	1
de la Cruz Almaráz, M	1
Ruiz de Adana, Mde L	1
Olveira, G	1
Tinahones, F	1
Esteva, I	1
Scaglioni, S	1
Verduci, E	1
Salvioni, M	1
Biondi, ML	1
Radaelli, G	1
Agostoni, C	1
Giovannini, M	1
Peeters, A	1
Beckers, S	1
Mertens, I	1
Van Hul, W	1
Van Gaal, L	1
Franks, PW	1
Jablonski, KA	1
Delahanty, L	1
Hanson, RL	1
Kahn, SE	1
Altshuler, D	1
Knowler, WC	1
Florez, JC	1
Loomba, R	1
Hwang, SJ	1
O'Donnell, CJ	1
Ellison, RC	1
Vasan, RS	1
D'Agostino, RB	1
Liang, TJ	1
Fox, CS	1
Metzger, BE	1
Ravnikar, V	1
Vileisis, RA	1
Freinkel, N	1
Lombardo, YB	1
Hron, WT	1
Sobocinski, KA	1
Menahan, LA	1
Hoffer, LJ	2
Bistrian, BR	2
Young, VR	2
Blackburn, GL	1
Matthews, DE	2
Minuk, HL	1
Hanna, AK	1
Marliss, EB	1
Vranic, M	1
Zinman, B	2
Johnston, DG	1
Alberti, KG	2
Nattrass, M	2
Barnes, AJ	1
Bloom, SR	1
Joplin, GF	1
Beylot, M	1
Riou, JP	1
Bienvenu, F	1
Mornex, R	1
Naismith, DJ	1
Holdsworth, MD	1
Bailey, JL	1
Flewitt, AP	1
Emery, PW	1
Swaminathan, R	1
Morgan, DB	1
Wales, JK	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
[NCT00004992]	Phase 3	3,234 participants (Actual)	Interventional	1996-07-31	Completed
Do Preoperative Carbohydrate Drinks Prevent Preoperative Catabolism in Mothers Undergoing Elective Caesarean Section? A Randomised Controlled Study[NCT03220997]		200 participants (Anticipated)	Interventional	2017-08-31	Not yet recruiting
Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation: Pilot Study on Patients With Metabolic Syndrome[NCT05275608]		40 participants (Anticipated)	Interventional	2022-11-07	Recruiting
Modulation of Insulin Secretion and Insulin Sensitivity in Bangladeshi Type 2 Diabetic Subjects by an Insulin Sensitizer Pioglitazone and T2DM Association With PPARG Gene Polymorphism.[NCT01589445]	Phase 4	77 participants (Actual)	Interventional	2008-11-30	Completed
[NCT00005270]		0 participants	Observational	1995-09-30	Completed
Thyroid Hormone-Induced Lipolysis: An In Vivo Microdialysis Study[NCT00312715]		41 participants (Actual)	Observational	2006-04-03	Completed
Effects of Pharmacologic Block of Type-1 Deiodinase on Thyroid Hormone Action and on the Circulating Levels of T3 in Hypothyroid Patients[NCT01801033]		0 participants (Actual)	Observational	2013-01-04	Withdrawn
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug

Comparison of Changes in Fasting Serum Insulin (FSI)With Pioglitazone and Metformin

Intervention	mmol/l (Mean)
	Baseline FSG	3rd Month FSG
Metformin ( 002 Group)	6.2	6.5
Pioglitazone (001 Group)	6.9	5.4

Comparison of Changes in Glycosylated Hemoglobin (HbA1c)With Pioglitazone and Metformin

Intervention	μU/ml (Mean)
	Baseline FSI	3rd month FSI
Metformin ( 002 Group)	13.0	13.9
Pioglitazone (001 Group)	16.2	12.3

Comparison of Changes in HOMA Percent B and HOMA Percent S With Pioglitazone and Metformin

Intervention	percentage (Mean)
	Baseline HbA1c	3rd month HbA1c
Metformin ( 002 Group)	7.8	7.0
Pioglitazone (001 Group)	7.3	6.7

"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostatic Model Assessment of Beta cell function(HOMA percent B) Analysis 2: Homeostatic Model Assessment of Insulin Sensitivity (Homa percent S)" (NCT01589445)
Timeframe: 3 months for each drug

Comparison of Changes in Insulin Levels (HOMA IR,QUICKI) With Pioglitazone and Metformin

Intervention	percentage (Mean)
	Baseline HOMA percent beta cells function	3rd month HOMA percent beta cells function	Baseline HOMA percent sensitivity	3rd month HOMA percent sensitivity
Metformin ( 002 Group)	109.3	116.0	76.2	67.2
Pioglitazone (001 Group)	118.9	132.3	51.1	69.3

"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostasis Model Assessment Insulin Resistance(HOMA IR) Analysis 2: Quantitative Insulin sensitivity Check Index(QUICKI)" (NCT01589445)
Timeframe: 3 months for each drug

Comparison of Changes in Lipid Profiles With Pioglitazone and Metformin

Intervention	Score on a scale ( SI unit) (Mean)
	Baseline QUICKI	3rd month QUICKI	Baseline HOMA IR	3rd month HOMA IR
Metformin ( 002 Group)	0.57	0.54	3.7	4.3
Pioglitazone (001 Group)	0.52	0.59	5.1	2.9

"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1:Total Cholesterol(TC) Analysis 2:Triglyceride(TG) Analysis 3:High Density Lipoprotein(HDL) Analysis 4:Low Density Lipoprotein(LDL)" (NCT01589445)
Timeframe: 3 months for each drug

Intervention	mg/dl (Mean)
	Baseline TC	3rd month TC	Baseline TG	3rd month TG	Baseline HDL	3rd month HDL	Baseline LDL	3rd month LDL
Metformin (002 Group)	193.0	177.0	166.0	175.0	34.4	34.7	125.6	112.0
Pioglitazone (001 Group)	182.0	178	183	195	33	33.2	112.8	105.5

Article	Year
COVID-19 and liver disease: An update. Gastroenterologia y hepatologia, 2020, Volume: 43, Issue:8 Topics: Adenosine Monophosphate; Age Factors; Alanine; Antiviral Agents; Betacoronavirus; Bile Ducts; Chemic	2020
Why Are Branched-Chain Amino Acids Increased in Starvation and Diabetes? Nutrients, 2020, Oct-11, Volume: 12, Issue:10 Topics: Alanine; Amino Acids, Branched-Chain; Diabetes Mellitus; Fatty Acids; Female; Glycolysis; Humans; In	2020
The predicted risk of adverse pregnancy outcomes as a result of treatment-associated obesity in a hypothetical population receiving tenofovir alafenamide/emtricitabine/dolutegravir, tenofovir disoproxil fumarate/emtricitabine/dolutegravir or tenofovir dis AIDS (London, England), 2021, 12-15, Volume: 35, Issue:Suppl 2 Topics: Alanine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Emtricitabine; Female; Heterocyclic	2021
Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis. Journal of medical genetics, 2003, Volume: 40, Issue:10 Topics: Alanine; Body Mass Index; Cohort Studies; Coronary Artery Disease; Female; Genotype; Humans; Male; O	2003
The use of isotope turnover techniques in the study of carbohydrate metabolism in man. Clinics in endocrinology and metabolism, 1976, Volume: 5, Issue:3 Topics: Acromegaly; Alanine; Blood Glucose; Carbohydrate Metabolism; Carbon Dioxide; Carbon Isotopes; Ethano	1976
Amino acid metabolism in man. Annual review of biochemistry, 1975, Volume: 44 Topics: Alanine; Amino Acids; Brain; Diabetes Mellitus; Erythrocytes; Glucagon; Glucocorticoids; Gluconeogen	1975
Metabolic effects of glucocorticoids in man. Nutrition reviews, 1974, Volume: 32, Issue:10 Topics: Adolescent; Adult; Alanine; Amino Acids; Blood Glucose; Cortisone; Cushing Syndrome; Dexamethasone;	1974
Blood glucose and cluconeogenesis in fasting man. Archives of internal medicine, 1969, Volume: 123, Issue:3 Topics: Adult; Alanine; Amino Acids; Blood Glucose; Brain; Fasting; Female; Gluconeogenesis; Homeostasis; Hu	1969
Interactions between carbohydrate, protein, and fat metabolism in starvation. Nutrition reviews, 1969, Volume: 27, Issue:9 Topics: Alanine; Amino Acids; Ammonia; Carbohydrate Metabolism; Gluconeogenesis; Glycerol; Glycine; Humans;	1969

Article	Year
Sesame Oil Ameliorates Alanine Aminotransferase, Aspartate Aminotransferase, and Fatty Liver Grade in Women with Nonalcoholic Fatty Liver Disease Undergoing Low-Calorie Diet: A Randomized Double-Blind Controlled Trial. International journal of clinical practice, 2022, Volume: 2022 Topics: Alanine; Alanine Transaminase; Aspartate Aminotransferases; Caloric Restriction; Diet, Reducing; Fem	2022
Fatty acid-binding protein 2 Ala54Thr genotype is associated with insulin resistance and leptin levels changes after a high monounsaturated fat diet in obese non-diabetic patients. Journal of endocrinological investigation, 2013, Volume: 36, Issue:6 Topics: Adult; Alanine; Amino Acid Substitution; Diet, High-Fat; Dietary Fats, Unsaturated; Fatty Acid-Bindi	2013
The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program. Diabetologia, 2007, Volume: 50, Issue:12 Topics: Adult; Alanine; Amino Acid Substitution; Body Composition; Chromans; Diabetes Mellitus, Type 2; Diet	2007
Metabolic effects of very low calorie weight reduction diets. The Journal of clinical investigation, 1984, Volume: 73, Issue:3 Topics: Alanine; Amino Acids; Diet, Reducing; Energy Intake; Female; Humans; Leucine; Nitrogen; Obesity	1984
Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects. Diabetes, 1992, Volume: 41, Issue:11 Topics: 3-Hydroxybutyric Acid; Alanine; Blood Glucose; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Ty	1992
Alanine flux in obese and healthy humans as evaluated by 15N- and 2H3-labeled alanines. The American journal of clinical nutrition, 1988, Volume: 48, Issue:4 Topics: Adult; Alanine; Amino Acids; Female; Gas Chromatography-Mass Spectrometry; Humans; Infusions, Intrav	1988

Article	Year
Real-world treatment patterns and clinical outcomes for inpatients with COVID-19 in the US from September 2020 to February 2021. PloS one, 2021, Volume: 16, Issue:12 Topics: Adenosine Monophosphate; Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Anti-Inflammatory Agen	2021
Amino acid signatures in relation to polycystic ovary syndrome and increased risk of different metabolic disturbances. Reproductive biomedicine online, 2022, Volume: 44, Issue:4 Topics: Alanine; Amino Acids; Body Mass Index; Female; Glycine; Humans; Insulin Resistance; Lysine; Metaboli	2022
Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids. Cell reports, 2022, 04-26, Volume: 39, Issue:4 Topics: Alanine; Alanine Transaminase; Amino Acids; Animals; Diabetes Mellitus; Gluconeogenesis; Glucose; Hu	2022
The impact of obesity and dyslipidemia on Remdesivir effectiveness in hospitalized patients with SARS-CoV-2-related pneumonia: An observational study. Nutrition, metabolism, and cardiovascular diseases : NMCD, 2022, Volume: 32, Issue:7 Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Dyslipidemias; Humans;	2022
Associations of serum amino acids with insulin resistance among people with and without overweight or obesity: A prospective study in Japan. Clinical nutrition (Edinburgh, Scotland), 2022, Volume: 41, Issue:8 Topics: Alanine; Animals; Humans; Insulin; Insulin Resistance; Isoleucine; Japan; Methionine; Obesity; Overw	2022
The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transferase in adult women. Endocrinology, diabetes & metabolism, 2022, Volume: 5, Issue:6 Topics: Adult; Alanine; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Cross-Secti	2022
[Plasma amino acids levels in 1859 physical examination subjects in Hangzhou City in 2020]. Wei sheng yan jiu = Journal of hygiene research, 2022, Volume: 51, Issue:6 Topics: Alanine; Amino Acids; Chromatography, Liquid; Female; Humans; Leucine; Male; Methionine; Middle Aged	2022
Case 17-2020: A 68-Year-Old Man with Covid-19 and Acute Kidney Injury. The New England journal of medicine, 2020, May-28, Volume: 382, Issue:22 Topics: Acute Kidney Injury; Adenosine Monophosphate; Aged; Alanine; Amides; Anti-Inflammatory Agents; Antic	2020
Idiopathic nonhistaminergic acquired angioedema in a patient with coronavirus disease 2019. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2020, Volume: 125, Issue:5 Topics: Adenosine Monophosphate; Adult; Alanine; Ampicillin; Angioedema; Betacoronavirus; Coronavirus Infect	2020
Using "old" medications to fight new COVID-19: Re-purposing with a purpose. Journal of molecular and cellular cardiology, 2020, Volume: 146 Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Betaco	2020
Clinical outcomes of hospitalised patients with COVID-19 and chronic inflammatory and autoimmune rheumatic diseases: a multicentric matched cohort study. Annals of the rheumatic diseases, 2020, Volume: 79, Issue:12 Topics: Adenosine Monophosphate; Age Factors; Aged; Alanine; Antiviral Agents; Arthritis, Psoriatic; Arthrit	2020
Preferential use of dexamethasone for fetal lung maturation in severe coronavirus disease 2019. American journal of obstetrics & gynecology MFM, 2020, Volume: 2, Issue:4 Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Compassionate Use Trials; COVID-19; Dexam	2020
Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats. Amino acids, 2020, Volume: 52, Issue:10 Topics: Adipose Tissue, White; Alanine; Aminomethyltransferase; Animals; Appetite Regulation; Body Weight; D	2020
Pre-diagnostic biomarkers of type 2 diabetes identified in the UAE's obese national population using targeted metabolomics. Scientific reports, 2020, 10-19, Volume: 10, Issue:1 Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Amino Acids, Branched-Chain; Biomarkers; Chromatography, Liqu	2020
Summary for Patients: Weight and Metabolic Changes After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in People Living With HIV. Annals of internal medicine, 2021, Volume: 174, Issue:6 Topics: Adult; Alanine; Anti-HIV Agents; HIV Infections; Humans; Lipids; Obesity; Tenofovir; Weight Gain	2021
Weight and Metabolic Changes After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in People Living With HIV : A Cohort Study. Annals of internal medicine, 2021, Volume: 174, Issue:6 Topics: Adult; Alanine; Anti-HIV Agents; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Fem	2021
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes. Nature metabolism, 2021, Volume: 3, Issue:3 Topics: Alanine; Alanine Transaminase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, An	2021
l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. Molecular metabolism, 2018, Volume: 17 Topics: Adenosine Triphosphate; Alanine; Amino Acids; AMP-Activated Protein Kinases; Animals; Carbohydrate M	2018
Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation. PloS one, 2019, Volume: 14, Issue:6 Topics: Alanine; Breast Neoplasms; Cell Line, Tumor; Citrate (si)-Synthase; Colonic Neoplasms; Female; Gene	2019
The carbon isotope ratio of alanine in red blood cells is a new candidate biomarker of sugar-sweetened beverage intake. The Journal of nutrition, 2013, Volume: 143, Issue:6 Topics: Adolescent; Adult; Alanine; Alaska; Beverages; Biomarkers; Body Mass Index; Carbon Isotopes; Diet; D	2013
The association between the Pro12Ala variant in the PPARγ2 gene and type 2 diabetes mellitus and obesity in a Chinese population. PloS one, 2013, Volume: 8, Issue:8 Topics: Adult; Alanine; Amino Acid Substitution; Asian People; Blood Glucose; Body Mass Index; China; Diabet	2013
The Interaction Between β-3 Adrenergic Receptor and Peroxisome Proliferator-Activated Receptor Gamma Gene Polymorphism to Periodontal Disease in Community-Dwelling Elderly Japanese. Journal of periodontology, 2015, Volume: 86, Issue:8 Topics: Aged; Alanine; Arginine; Body Mass Index; C-Reactive Protein; Epistasis, Genetic; Female; Gene-Envir	2015
Benefits of L-alanine or L-arginine supplementation against adiposity and glucose intolerance in monosodium glutamate-induced obesity. European journal of nutrition, 2017, Volume: 56, Issue:6 Topics: Adiposity; Alanine; Animals; Arginine; Blood Glucose; Cholesterol; Dietary Supplements; Gene Express	2017
Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity. International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity, 2009, Volume: 4, Issue:2 Topics: Adiponectin; Adolescent; Alanine; Body Mass Index; Child; Cholesterol; Cross-Sectional Studies; Fema	2009
[Association of the Pro12Ala and C1431T polymorphism of the PPAR gamma2 gene and their haplotypes with obesity and type 2 diabetes]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2008, Volume: 25, Issue:4 Topics: Alanine; Amino Acid Substitution; Asian People; Diabetes Mellitus, Type 2; Female; Gene Frequency; G	2008
Polymorphism of Pro12Ala in the peroxisome proliferator-activated receptor gamma2 gene in Iranian diabetic and obese subjects. Metabolic syndrome and related disorders, 2009, Volume: 7, Issue:5 Topics: Alanine; Asian People; Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Diabetes Mell	2009
Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. Clinical biochemistry, 2009, Volume: 42, Issue:16-17 Topics: Alanine; Case-Control Studies; Female; Humans; Leptin; Male; Obesity; PPAR gamma; Proline; Risk Fact	2009
Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, Volume: 30, Issue:8 Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Brain; Diabetes Mellitus, Type 2; gamma	2010
Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle. The Journal of nutritional biochemistry, 2011, Volume: 22, Issue:5 Topics: Acetyl-CoA Carboxylase; Adipose Tissue, White; Alanine; Animals; Arginine; Chemical Phenomena; Dieta	2011
Polymorphism Ala54Thr of fatty acid-binding protein 2: Allelic frequencies and influence on cardiovascular risk factors in a multicenter study of Castilla y Leon. Annals of nutrition & metabolism, 2010, Volume: 57, Issue:3-4 Topics: Adult; Alanine; Anthropometry; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Cross-S	2010
Gender differences in the effects of peroxisome proliferator-activated receptor γ2 gene polymorphisms on metabolic adversity in patients with schizophrenia or schizoaffective disorder. Progress in neuro-psychopharmacology & biological psychiatry, 2011, Jan-15, Volume: 35, Issue:1 Topics: Adult; Alanine; Female; Gene Frequency; Genotype; Humans; Male; Metabolic Diseases; Metabolic Syndro	2011
[Analysis of the FABP2 gene Ala54Thr polymorphism in non-obese and obese Chinese]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2011, Volume: 42, Issue:1 Topics: Aged; Alanine; Asian People; Cholesterol, HDL; Fatty Acid-Binding Proteins; Female; Humans; Male; Mi	2011
PPAR-gamma2 pro12Ala polymorphism is associated with post-challenge abnormalities of glucose homeostasis in children and adolescents with obesity. Journal of pediatric endocrinology & metabolism : JPEM, 2011, Volume: 24, Issue:1-2 Topics: Adolescent; Alanine; Amino Acid Substitution; Child; Cohort Studies; Diabetes Mellitus, Type 2; Fema	2011
A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. BMC systems biology, 2011, Oct-31, Volume: 5 Topics: Adipocytes; Alanine; Computer Simulation; Diabetes Mellitus; Genome, Human; Hepatocytes; Humans; Met	2011
Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity. Amino acids, 2013, Volume: 44, Issue:2 Topics: Alanine; Animals; Blood Glucose; Diet, High-Fat; Dietary Proteins; Dietary Supplements; Humans; Insu	2013
PPARγ2 Pro12Ala polymorphism is associated with improved lipoprotein lipase functioning in adipose tissue of insulin resistant obese women. Gene, 2012, Dec-15, Volume: 511, Issue:2 Topics: Adipose Tissue; Adult; Alanine; Base Sequence; DNA Primers; Female; Humans; Insulin Resistance; Lipo	2012
Effect of fatty acid-binding protein 2 Ala54Thr genotype on weight loss and cardiovascular risk factors after a high-polyunsaturated fat diet in obese patients. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2012, Volume: 60, Issue:8 Topics: Adult; Alanine; Caloric Restriction; Cardiovascular Diseases; Dietary Fats, Unsaturated; Fatty Acid-	2012
Amerindians show no association of PPAR-γ2 gene Ala12 allele and obesity: an "unthrifty" variant population genetics. Molecular biology reports, 2013, Volume: 40, Issue:2 Topics: Adult; Aged; Alanine; Amino Acid Substitution; Female; Gene Frequency; Genetic Association Studies;	2013
Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus. Hormone research, 2002, Volume: 58, Issue:3 Topics: Aged; Alanine; Alleles; Antigens, CD; Body Mass Index; Cytokines; Diabetes Mellitus, Type 2; Female;	2002
Lack of association between the uncoupling protein-2 Ala55Val gene polymorphism and phenotypic features of the Metabolic Syndrome. Biochimica et biophysica acta, 2002, Nov-20, Volume: 1588, Issue:2 Topics: Alanine; Alleles; Blood Glucose; Blood Pressure; Humans; Insulin; Ion Channels; Male; Membrane Trans	2002
Effects of dual angiotensin-converting enzyme and neutral endopeptidase 24-11 chronic inhibition by mixanpril on insulin sensitivity in lean and obese Zucker rats. Journal of cardiovascular pharmacology, 2003, Volume: 41, Issue:2 Topics: Alanine; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Flow Velocity; Blood Glucose; Capt	2003
A flexible route to (5R)-thiolactomycin, a naturally occurring inhibitor of fatty acid synthesis. Organic letters, 2002, Oct-31, Volume: 4, Issue:22 Topics: Acetyltransferases; Alanine; Anti-Bacterial Agents; Fatty Acid Synthase, Type II; Fatty Acids; Human	2002
Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo. Metabolism: clinical and experimental, 2003, Volume: 52, Issue:6 Topics: Alanine; Amino Acid Substitution; Aminobutyrates; Animals; Blood; Cell Line; Cricetinae; Cricetulus;	2003
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Developmental cell, 2003, Volume: 5, Issue:4 Topics: Adiponectin; Adipose Tissue; Adipose Tissue, Brown; Alanine; Amino Acid Substitution; Animals; Blood	2003
Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels. The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:12 Topics: Adult; Alanine; Alleles; DNA; Female; Gene Frequency; Genotype; Humans; Obesity; Polycystic Ovary Sy	2003
Influence of the polymorphisms Tpr64Arg in the beta 3-adrenergic receptor gene and Pro12Ala in the PPAR gamma 2 gene on metabolic syndrome-related phenotypes in an indigenous population of the Brazilian Amazon. Diabetes care, 2004, Volume: 27, Issue:2 Topics: Alanine; Arginine; Brazil; Female; Humans; Male; Metabolic Syndrome; Obesity; Phenotype; Polymorphis	2004
Intestinal FABP2 A54T polymorphism: association with insulin resistance and obesity in women. Obesity research, 2004, Volume: 12, Issue:2 Topics: Adult; Alanine; Alleles; Body Mass Index; Carrier Proteins; Fatty Acid-Binding Proteins; Female; Gen	2004
[Association of Pro12Ala mutation in peroxisome proliferator-activated receptor gamma 2 with obesity and diabetes in Chinese population]. Wei sheng yan jiu = Journal of hygiene research, 2004, Volume: 33, Issue:3 Topics: Adult; Alanine; Diabetes Mellitus; Female; Gene Frequency; Humans; Male; Mutation; Obesity; Polymorp	2004
The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes. Diabetes, 2004, Volume: 53, Issue:7 Topics: Adipose Tissue; Adult; Alanine; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Genotype; G	2004
[Is obesity associated with a polymorphism Pro12Ala and Pro115Gln in PPARgamma gene?]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2004, Volume: 16, Issue:95 Topics: Alanine; Case-Control Studies; Female; Glutamine; Heterozygote; Homozygote; Humans; Male; Obesity; P	2004
PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity in childhood obesity. Pediatric research, 2005, Volume: 57, Issue:1 Topics: Adolescent; Alanine; Child; Exons; Female; Genetic Variation; Genotype; Humans; Insulin; Insulin Res	2005
The Arg64 allele of the beta 3-adrenoceptor gene but not the -3826G allele of the uncoupling protein 1 gene is associated with increased leptin levels in the Spanish population. Metabolism: clinical and experimental, 2004, Volume: 53, Issue:11 Topics: Adipocytes; Adult; Alanine; Arginine; Blood Glucose; Body Mass Index; Carrier Proteins; Cholesterol;	2004
[Is obesity associated with a polymorphism Pro12Ala and Pro115Gln in the PPARgamma gene?]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2004, Volume: 17, Issue:100 Topics: Alanine; Body Mass Index; Case-Control Studies; Female; Gene Frequency; Glycine; Humans; Male; Obesi	2004
Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population. BMC medical genetics, 2005, Mar-22, Volume: 6 Topics: Adolescent; Adult; Alanine; Amino Acid Substitution; Case-Control Studies; Child; Diabetes Mellitus,	2005
Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes. Journal of human hypertension, 2006, Volume: 20, Issue:9 Topics: Alanine; Alleles; Blood Pressure; Body Mass Index; Diabetes Mellitus, Type 2; Female; Humans; Hypert	2006
Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid. The Journal of nutrition, 2006, Volume: 136, Issue:9 Topics: Adolescent; Adult; Aged; Alanine; Alleles; Body Mass Index; Cross-Sectional Studies; Diabetes Mellit	2006
PPAR-gamma2 Pro12Ala variant, insulin resistance and plasma long-chain polyunsaturated fatty acids in childhood obesity. Pediatric research, 2006, Volume: 60, Issue:4 Topics: Alanine; Child; Fatty Acids, Unsaturated; Female; Gene Frequency; Humans; Insulin Resistance; Male;	2006
The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men. Endocrine, 2007, Volume: 31, Issue:2 Topics: Abdominal Fat; Adiposity; Adult; Alanine; Case-Control Studies; Female; Glycine; Humans; Male; Middl	2007
Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham heart study. Gastroenterology, 2008, Volume: 134, Issue:4 Topics: Adult; Age of Onset; Alanine; Aspartate Aminotransferases; Biomarkers; Cardiovascular Diseases; Fema	2008
"Accelerated starvation" and the skipped breakfast in late normal pregnancy. Lancet (London, England), 1982, Mar-13, Volume: 1, Issue:8272 Topics: 3-Hydroxybutyric Acid; Alanine; Blood Glucose; Diabetes Mellitus; Fasting; Fatty Acids, Nonesterifie	1982
A metabolic profile of fed and fasting genetically obese mice at 4-5 months of age. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1984, Volume: 16 Suppl 1 Topics: Alanine; Animals; Blood Glucose; Carbohydrate Metabolism; Diet; Fatty Acids, Nonesterified; Insulin	1984
Metabolic response to moderate exercise in obese man during prolonged fasting. The American journal of physiology, 1980, Volume: 238, Issue:4 Topics: Adult; Alanine; Blood Glucose; Fasting; Fatty Acids, Nonesterified; Female; Glycogen; Heart Rate; Hu	1980
Hormonal and metabolic rhythms in Cushing's syndrome. Metabolism: clinical and experimental, 1980, Volume: 29, Issue:11 Topics: Adolescent; Adult; Alanine; Blood Glucose; Circadian Rhythm; Cushing Syndrome; Fatty Acids, Nonester	1980
Increased ketonaemia in hyperthyroidism. Evidence for a beta-adrenergic mechanism. Diabetologia, 1980, Volume: 19, Issue:6 Topics: Adult; Aged; Alanine; Blood Glucose; Diet, Reducing; Energy Intake; Female; Glucagon; Glycerol; Huma	1980
Carbohydrate conservation in the obese: a theory to explain the ease of weight gain. Annals of nutrition & metabolism, 1982, Volume: 26, Issue:1 Topics: Adult; Alanine; Blood Glucose; Body Composition; Body Weight; Dietary Carbohydrates; Energy Intake;	1982
Effect of fasting on the disappearance of injected alanine and 3-hydroxybutyrate in obese subjects. Clinical science (London, England : 1979), 1982, Volume: 62, Issue:1 Topics: 3-Hydroxybutyric Acid; Adult; Aged; Alanine; Blood Glucose; Fasting; Female; Half-Life; Humans; Hydr	1982
The effect of starvation on leucine, alanine and glucose metabolism in obese subjects. European journal of clinical investigation, 1995, Volume: 25, Issue:8 Topics: Adult; Alanine; Fatty Acids, Nonesterified; Female; Glucose; Humans; Insulin; Leucine; Male; Metabol	1995
Insulin and Na-dependent alanine transport in skeletal muscle of obese Zucker (fa/fa) rats. The American journal of physiology, 1994, Volume: 267, Issue:6 Pt 2 Topics: Alanine; Animals; Biological Transport; Blood Glucose; Body Weight; Cell Membrane; Insulin; Kinetics	1994
Changes in alanine turnover rate due to nutritional and genetic obesity in the rat. Biochemistry and molecular biology international, 1994, Volume: 34, Issue:1 Topics: Alanine; Analysis of Variance; Animals; Body Weight; Diet; Disease Models, Animal; Energy Intake; Ma	1994
In vitro substrate utilization for lipid synthesis in liver explants from hyperthyroid chickens. Comparative biochemistry and physiology. Comparative physiology, 1993, Volume: 106, Issue:4 Topics: Acetates; Alanine; Animals; Carbon Dioxide; Chickens; Diet; Dietary Proteins; Growth; Hyperthyroidis	1993
L-alanine transport in small intestine brush-border membrane vesicles of obese rats. Biochimica et biophysica acta, 1994, Jun-22, Volume: 1192, Issue:2 Topics: Alanine; Animals; Biological Transport; Diet; Intestine, Small; Kinetics; Microvilli; Obesity; Rats;	1994
Splanchnic ammonia management in genetic and dietary obesity in the rat. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1994, Volume: 18, Issue:4 Topics: Alanine; Ammonia; Animals; Aorta; Diet; Fasting; Glutamine; Hepatic Veins; Liver; Male; Obesity; Por	1994
Alanine as a lipogenic precursor in isolated hepatocytes from obese Zucker rats. Cellular and molecular biology (Noisy-le-Grand, France), 1993, Volume: 39, Issue:6 Topics: Acetyl Coenzyme A; Alanine; Alanine Transaminase; Animals; Cells, Cultured; Citrates; Coumaric Acids	1993
Suppression of gluconeogenesis after a 3-day fast does not deplete liver glycogen in patients with NIDDM. Diabetes, 1994, Volume: 43, Issue:2 Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Ethanol; Fasting; Fatty	1994
Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM. The American journal of physiology, 1996, Volume: 270, Issue:3 Pt 1 Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fatt	1996
The biochemical basis of increased hepatic glucose production in a mouse model of type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia, 1995, Volume: 38, Issue:12 Topics: Alanine; Animals; Body Mass Index; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dietary Fats; Disea	1995
Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects. European journal of clinical investigation, 1997, Volume: 27, Issue:5 Topics: Adult; Alanine; Alleles; Carrier Proteins; Codon; Fatty Acid-Binding Protein 7; Fatty Acid-Binding P	1997
Very low calorie diet (VLCD): a useful alternative in the treatment of the obese NIDDM patient. Diabetes research and clinical practice, 1997, Volume: 36, Issue:2 Topics: Adult; Alanine; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Ty	1997
No relationship between identified variants in the uncoupling protein 2 gene and energy expenditure. European journal of endocrinology, 1998, Volume: 139, Issue:2 Topics: Aged; Alanine; Amino Acid Substitution; Energy Metabolism; Exons; Female; Genetic Variation; Genotyp	1998
Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. Diabetes, 1998, Volume: 47, Issue:11 Topics: Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Exercise; Fe	1998
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus. Biochemical and biophysical research communications, 1999, Jan-19, Volume: 254, Issue:2 Topics: Adult; Alanine; Amino Acid Substitution; Cholesterol; Codon; Coronary Disease; Diabetes Mellitus; Di	1999
The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects. Diabetologia, 1999, Volume: 42, Issue:6 Topics: Adult; Alanine; Amino Acid Substitution; Codon; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female	1999
Ammonium uptake and urea production in hepatocytes from lean and obese Zucker rats. Molecular and cellular biochemistry, 1999, Volume: 200, Issue:1-2 Topics: Alanine; Animals; Biological Transport, Active; In Vitro Techniques; Liver; Male; Nitrogen; Obesity;	1999
Significance of Pro12Ala mutation in peroxisome proliferator-activated receptor-gamma2 in Korean diabetic and obese subjects. The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:5 Topics: Alanine; Amino Acid Substitution; Asian People; Body Mass Index; Diabetes Mellitus; Female; Genotype	2000
Effects of an Ala54Thr polymorphism in the intestinal fatty acid-binding protein on responses to dietary fat in humans. Journal of lipid research, 2000, Volume: 41, Issue:12 Topics: Adipose Tissue; Adult; Alanine; Carrier Proteins; Dietary Fats; Fatty Acid-Binding Protein 7; Fatty	2000
Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:2 Topics: Alanine; Amino Acid Substitution; Blood Glucose; Blood Pressure; Body Mass Index; Chromosomes, Human	2001
A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity. European journal of endocrinology, 2001, Volume: 144, Issue:3 Topics: Aging; Alanine; Alleles; Amino Acid Substitution; Anthropometry; Australia; Blood Pressure; Choleste	2001
The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2001, Volume: 25, Issue:4 Topics: Adult; Alanine; Calorimetry, Indirect; Energy Metabolism; Exercise; Exercise Test; Female; Genotype;	2001
Acute effect of the dual angiotensin-converting enzyme and neutral endopeptidase 24-11 inhibitor mixanpril on insulin sensitivity in obese Zucker rat. British journal of pharmacology, 2001, Volume: 133, Issue:4 Topics: Alanine; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal;	2001
Sibling-based association study of the PPARgamma2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study. Stanford Asian-Pacific Program in Hypertension and Insulin Resistance. Journal of molecular medicine (Berlin, Germany), 2001, Volume: 79, Issue:11 Topics: Adult; Age Factors; Aged; Alanine; Alleles; Blood Glucose; China; Family Health; Female; Genotype; G	2001
Sibling-based association study of the PPARgamma2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study. Stanford Asian-Pacific Program in Hypertension and Insulin Resistance. Journal of molecular medicine (Berlin, Germany), 2001, Volume: 79, Issue:11 Topics: Adult; Age Factors; Aged; Alanine; Alleles; Blood Glucose; China; Family Health; Female; Genotype; G	2001
Sibling-based association study of the PPARgamma2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study. Stanford Asian-Pacific Program in Hypertension and Insulin Resistance. Journal of molecular medicine (Berlin, Germany), 2001, Volume: 79, Issue:11 Topics: Adult; Age Factors; Aged; Alanine; Alleles; Blood Glucose; China; Family Health; Female; Genotype; G	2001
Sibling-based association study of the PPARgamma2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study. Stanford Asian-Pacific Program in Hypertension and Insulin Resistance. Journal of molecular medicine (Berlin, Germany), 2001, Volume: 79, Issue:11 Topics: Adult; Age Factors; Aged; Alanine; Alleles; Blood Glucose; China; Family Health; Female; Genotype; G	2001
No association found between the Ala54Thr polymorphism of FABP2 gene and obesity and obesity with dyslipidemia in Japanese schoolchildren. Journal of atherosclerosis and thrombosis, 2001, Volume: 8, Issue:3 Topics: Adolescent; Alanine; Base Sequence; Carrier Proteins; Child; DNA Primers; Fatty Acid-Binding Protein	2001
Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Diabetes, 2002, Volume: 51, Issue:3 Topics: Alanine; Blood Glucose; Glucose Clamp Technique; Heterozygote; Homozygote; Humans; Insulin; Insulin	2002
Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Diabetes, 2002, Volume: 51, Issue:3 Topics: Alanine; Blood Glucose; Glucose Clamp Technique; Heterozygote; Homozygote; Humans; Insulin; Insulin	2002
Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Diabetes, 2002, Volume: 51, Issue:3 Topics: Alanine; Blood Glucose; Glucose Clamp Technique; Heterozygote; Homozygote; Humans; Insulin; Insulin	2002
Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Diabetes, 2002, Volume: 51, Issue:3 Topics: Alanine; Blood Glucose; Glucose Clamp Technique; Heterozygote; Homozygote; Humans; Insulin; Insulin	2002
Regional muscle and adipose tissue amino acid metabolism in lean and obese women. American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:4 Topics: Abdomen; Adipose Tissue; Adult; Alanine; Amino Acids; Arteries; Body Composition; Body Constitution;	2002
Is a Pro12Ala polymorphism of the PPARgamma2 gene related to obesity and type 2 diabetes mellitus in the Czech population? Annals of the New York Academy of Sciences, 2002, Volume: 967 Topics: Adult; Alanine; Case-Control Studies; Czechoslovakia; Diabetes Mellitus, Type 2; Female; Genetics, P	2002
Serum hormone levels and tissue metabolism in pair-fed lean and obese Zucker rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1977, Volume: 9, Issue:3 Topics: Adipose Tissue; Alanine; Animals; Cyclic AMP; Fatty Acids; Female; Glucagon; Gluconeogenesis; Glycol	1977
The influence of glucagon on sodium retention after fasting. The New Zealand medical journal, 1977, Aug-24, Volume: 86, Issue:594 Topics: Adolescent; Adult; Alanine; Diet; Fasting; Female; Glucagon; Glucose; Humans; Middle Aged; Obesity;	1977
Sodium sparing effect of alanine in fasting obese females. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1979, Volume: 11, Issue:6 Topics: Adult; Alanine; Fasting; Female; Humans; Obesity; Potassium; Renin; Sodium	1979
Experimental basis of obesity. Bibliotheca nutritio et dieta, 1978, Issue:26 Topics: Acetates; Adenylyl Cyclases; Adipose Tissue; Alanine; Animals; Dietary Carbohydrates; Dietary Fats;	1978
Resistance of gluconeogenic and glycogenic pathways in obese-hyperglycemic mice. The American journal of physiology, 1975, Volume: 228, Issue:2 Topics: Alanine; Animals; Enzyme Activation; Female; Genotype; Gluconeogenesis; Glucose Tolerance Test; Glyc	1975
Regulation of protein metabolism in relation to adequacy of intake. Infusionstherapie und klinische Ernahrung, 1975, Volume: 2, Issue:2 Topics: Adaptation, Physiological; Alanine; Amino Acids; Dietary Proteins; Fasting; Gluconeogenesis; Glutama	1975
Effect of 24 hour fast in obese children. Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1976, Sep-30, Volume: 25, Issue:8 Topics: Adolescent; Alanine; Blood Glucose; Child; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Gr	1976
Effect of alanine and glycine on glucagon secretion in postabsorptive and fasting obese man. The Journal of clinical endocrinology and metabolism, 1975, Volume: 40, Issue:3 Topics: Adolescent; Adult; Alanine; Blood Glucose; Fasting; Female; Glucagon; Glycine; Humans; Insulin; Male	1975
Effect of ketone infusions on amino acid and nitrogen metabolism in man. The Journal of clinical investigation, 1975, Volume: 55, Issue:6 Topics: Adult; Alanine; Amino Acids; Blood Glucose; Fasting; Female; Glucagon; Humans; Hydroxybutyrates; Inf	1975
A comparison of the enzyme levels and the in vitro utilization of various substrates for lipogenesis in pair-fed lean and obese pigs. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 151, Issue:1 Topics: Acetates; Adipose Tissue; Alanine; Animals; Gluconeogenesis; Glucose; Glycerol; Glycolysis; Leucine;	1976
The metabolic fate of an oral 14C-alanine load in the obese Zucker rat. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, Volume: 16, Issue:3 Topics: Adipose Tissue; Adipose Tissue, Brown; Administration, Oral; Alanine; Animals; Female; Food Deprivat	1992
Amino acid uptake by liver of genetically obese Zucker rats. The Biochemical journal, 1991, Dec-01, Volume: 280 ( Pt 2) Topics: Alanine; Animals; Biological Transport; Cell Membrane; DNA; Glutamate-Ammonia Ligase; Glutaminase; G	1991
Effect of obesity on circulating intermediary metabolite concentrations in the absence of impaired glucose tolerance. International journal of obesity, 1991, Volume: 15, Issue:10 Topics: Adult; Alanine; Blood Glucose; Body Mass Index; C-Peptide; Fatty Acids, Nonesterified; Female; Gluco	1991
Contribution of glycerol and alanine to basal hepatic glucose production in the genetically obese (fa/fa) rat. The Biochemical journal, 1990, Sep-15, Volume: 270, Issue:3 Topics: Alanine; Animals; Glucose; Glycerol; Liver; Liver Glycogen; Metabolic Clearance Rate; Obesity; Rats;	1990
In vivo C14-L-alanine metabolism in rat dietary obesity induced by cafeteria diet. Biochemistry international, 1990, Volume: 20, Issue:2 Topics: Alanine; Amino Acids; Animals; Blood Glucose; Diet; Female; Food Deprivation; Glucose; Glycogen; Lac	1990
Plasma glucagon response to intravenous alanine in obese and non-obese subjects. Endocrinologia japonica, 1989, Volume: 36, Issue:5 Topics: Alanine; Fatty Acids; Glucagon; Glucose; Glucose Tolerance Test; Humans; Insulin; Obesity; Weight Lo	1989
Glutamine metabolism in isolated incubated adipocytes of the rat. The Biochemical journal, 1988, Feb-01, Volume: 249, Issue:3 Topics: Adipose Tissue; Alanine; Ammonia; Animals; Glucose; Glutamates; Glutamic Acid; Glutaminase; Glutamin	1988
Characterization of stages in development of obesity-diabetes syndrome in sand rat (Psammomys obesus). Diabetes, 1986, Volume: 35, Issue:6 Topics: Adipose Tissue; Age Factors; Alanine; Animals; Arvicolinae; Blood Glucose; Carbon Radioisotopes; Dia	1986
Insulin-stimulated glucose disposal is not increased in anorexia nervosa. The Journal of clinical endocrinology and metabolism, 1985, Volume: 60, Issue:2 Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Alanine; Anorexia Nervosa; Blood Glucose; Female; Humans;	1985
Glucagon secretion in obesity. Lancet (London, England), 1973, Apr-28, Volume: 1, Issue:7809 Topics: Adult; Alanine; Child; Diabetes Mellitus; Fasting; Glucagon; Gluconeogenesis; Glucose; Humans; Insul	1973
Hepatic metabolism in normal and genetically obese mice. Biochimica et biophysica acta, 1974, Apr-22, Volume: 343, Issue:2 Topics: Alanine; Amino Acids; Animals; Blood Glucose; Carbon Radioisotopes; Citrates; Female; Gluconeogenesi	1974
Transport of -aminoisobutyric acid in mammalian pancretic -cells. Diabetologia, 1971, Volume: 7, Issue:4 Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Butyrates; Cyclic AMP; D	1971
Effects of glucose and other modifiers of insulin release on the oxidative metabolism of amino acids in micro-dissected pancreatic islets. The Biochemical journal, 1971, Volume: 123, Issue:4 Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Citrates; Cyclic AMP; Depression, Chemical	1971
Glutamate-type hypothalamic-pituitary syndrome in mice treated with aspartate or cysteate in infancy. Journal of neural transmission, 1974, Volume: 35, Issue:3 Topics: Adipates; Alanine; Amino Acids, Dicarboxylic; Amino Acids, Sulfur; Animals; Animals, Newborn; Aspart	1974
The role of glucagon as a catabolic hormone. Surgical forum, 1974, Volume: 25, Issue:0 Topics: Alanine; Amino Acids; Ammonia; Carbon Radioisotopes; Fasting; Glucagon; Half-Life; Humans; Obesity;	1974
Weight reduction in obesity by outpatient semistarvation. JAMA, 1974, Nov-18, Volume: 230, Issue:7 Topics: Adult; Alanine; Body Weight; Calcium; Diet, Reducing; Evaluation Studies as Topic; Fasting; Female;	1974
Evaluation of alpha-cell function by infusion of alanine in normal, diabetic and obese subjects. The New England journal of medicine, 1973, Mar-08, Volume: 288, Issue:10 Topics: Adolescent; Adult; Alanine; Blood Glucose; Diabetes Mellitus; Glucagon; Humans; Injections, Intraven	1973
Changes of free amino acids in pancreatic beta-cells after starvation and substrate deprivation. Acta endocrinologica, 1974, Volume: 75, Issue:1 Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Carbon Radioisotopes; Chromatography,	1974
Uptake and oxidation of glutamic acid in mammalian pancreatic islets. Hormones, 1972, Volume: 3, Issue:3 Topics: Alanine; Animals; Arginine; Carbon Isotopes; Female; Galactose; Glucose; Glutamates; Glyburide; Hype	1972
Obesity: evidence of decreased secretion of glucagon. Science (New York, N.Y.), 1972, Nov-03, Volume: 178, Issue:4060 Topics: Adult; Alanine; Animals; Blood Glucose; Fasting; Glucagon; Humans; Injections, Intravenous; Insulin;	1972
Effects of oral alanine administration in fasting obese subjects. Metabolism: clinical and experimental, 1973, Volume: 22, Issue:7 Topics: Administration, Oral; Adult; Alanine; Blood Glucose; Female; Gluconeogenesis; Humans; Hydroxybutyrat	1973
Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man. The Journal of clinical investigation, 1973, Volume: 52, Issue:11 Topics: Adult; Alanine; Amino Acids; Blood Glucose; Cushing Syndrome; Dexamethasone; Dietary Proteins; Fasti	1973
[Experimental studies on the problem of insulin resistance in adipositas and diabetes mellitus, with the aid of New Zealand obese mice. Pathogenesis of the obese-hyperglycaemic syndrome (author's transl)]. Zeitschrift fur klinische Chemie und klinische Biochemie, 1973, Volume: 11, Issue:6 Topics: Adipose Tissue; Aging; Alanine; Animals; Body Weight; Carbon Radioisotopes; Diabetes Mellitus, Exper	1973
Effect of glucagon on amino acid and nitrogen metabolism in fasting man. Metabolism: clinical and experimental, 1974, Volume: 23, Issue:9 Topics: Acetoacetates; Adult; Alanine; Amino Acids; Ammonia; Blood Glucose; Blood Urea Nitrogen; Fasting; Fa	1974
[Effect of blood sugar decreasing sulfonylureas on the in vitro metabolism of glucose and amino acids in the beta-cells of the pancreas in mice]. Arzneimittel-Forschung, 1969, Volume: 19, Issue:8 Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Depression, Chemical; Female; Glucose; Hyp	1969
Uptake of alanine, arginine and leucine by mammalian pancreatic beta-cells. Endocrinology, 1971, Volume: 89, Issue:6 Topics: Alanine; Animals; Arginine; Carbon Isotopes; Diazoxide; Fructose; Glucose; Glyburide; Hyperglycemia;	1971
Carbohydrate metabolism of the isolated perfused liver of normal and genetically obese--hyperglycaemic (ob-ob) mice. The Biochemical journal, 1971, Volume: 125, Issue:3 Topics: Alanine; Animals; Carbohydrate Metabolism; Carbon Isotopes; Genes, Recessive; Gluconeogenesis; Gluco	1971
Alanine: key role in gluconeogenesis. Science (New York, N.Y.), 1970, Feb-13, Volume: 167, Issue:3920 Topics: Adult; Alanine; Amino Acids; Body Weight; Forearm; Gluconeogenesis; Humans; Middle Aged; Muscles; Ob	1970
Hormone and amino acid levels in altered nutritional states. The Journal of laboratory and clinical medicine, 1970, Volume: 76, Issue:5 Topics: Adult; Alanine; Amino Acids; Aminobutyrates; Female; Growth Hormone; Humans; Insulin; Isoleucine; Le	1970
Alteration in the urinary excretion rate of amino acids and nitrogen by dietary means in obese and normal human subjects. The Journal of laboratory and clinical medicine, 1971, Volume: 77, Issue:2 Topics: Adult; Alanine; Amino Acids; Creatinine; Female; Humans; Isoleucine; Leucine; Male; Nitrogen; Obesit	1971
Influence of dietary deprivations on plasma concentration of free amino acids of man. Journal of applied physiology, 1968, Volume: 25, Issue:1 Topics: Adolescent; Adult; Alanine; Amino Acids; Chromatography, Ion Exchange; Diet; Dietary Proteins; Femal	1968

alanine and Obesity