alanine has been researched along with Neurodegenerative Diseases in 13 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The potential use of OKN-007 in combination with neurotropic compounds such as the lanthionine ketamine esters is discussed for glioblastoma multiforme as well as for various other indications leading to dementia, such as aging, septic shock, and malaria infections." | 6.49 | Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines. ( Castro Faria Neto, HC; Floyd, RA; Hensley, K; Towner, RA; Zimmerman, GA, 2013) |
| "Here we describe a new strategy, HILAQ (Heavy Isotope Labeled Azidohomoalanine Quantification), to rapidly quantify the molecular vulnerability profile to oxytosis, which is an oxidative stress-induced programed cell death pathway that has been reported to be involved in aging and neurodegenerative diseases." | 3.85 | HILAQ: A Novel Strategy for Newly Synthesized Protein Quantification. ( Barkallah, S; Ma, Y; McClatchy, DB; Wood, WW; Yates, JR, 2017) |
| " The potential use of OKN-007 in combination with neurotropic compounds such as the lanthionine ketamine esters is discussed for glioblastoma multiforme as well as for various other indications leading to dementia, such as aging, septic shock, and malaria infections." | 2.49 | Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines. ( Castro Faria Neto, HC; Floyd, RA; Hensley, K; Towner, RA; Zimmerman, GA, 2013) |
| " magna assay revealed toxic effects of BMAA." | 1.62 | Presence of ß-N-methylamino-L-alanine in cyanobacteria and aquatic organisms from waters of Northern Poland; BMAA toxicity studies. ( Błaszczyk, A; Mazur-Marzec, H; Siedlecka-Kroplewska, K; Woźniak, M, 2021) |
| " We found that S421 phosphorylation mitigates neurodegeneration by increasing proteasome-dependent turnover of mHTT and reducing the presence of a toxic mHTT conformer." | 1.43 | Serine 421 regulates mutant huntingtin toxicity and clearance in mice. ( Daub, AC; Finkbeiner, S; Gu, X; Humbert, S; Kratter, IH; Lau, A; Masliah, E; Osmand, A; Saudou, F; Steffan, JS; Tsvetkov, AS; Weiberth, KF; Yang, XW; Zahed, H, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 4 (30.77) | 2.80 |
| Authors | Studies |
|---|---|
| Talavera Andújar, B | 1 |
| Aurich, D | 1 |
| Aho, VTE | 1 |
| Singh, RR | 1 |
| Cheng, T | 1 |
| Zaslavsky, L | 1 |
| Bolton, EE | 1 |
| Mollenhauer, B | 1 |
| Wilmes, P | 1 |
| Schymanski, EL | 1 |
| Xu, J | 1 |
| Yang, Z | 1 |
| Wang, R | 1 |
| He, F | 1 |
| Yan, R | 1 |
| Zhang, Y | 1 |
| Yu, L | 1 |
| Deng, W | 1 |
| Nie, Y | 1 |
| Silva da Fonsêca, V | 1 |
| Goncalves, VC | 1 |
| Augusto Izidoro, M | 1 |
| Guimarães de Almeida, AC | 1 |
| Luiz Affonso Fonseca, F | 1 |
| Alexandre Scorza, F | 1 |
| Finsterer, J | 1 |
| Scorza, CA | 1 |
| Błaszczyk, A | 1 |
| Siedlecka-Kroplewska, K | 1 |
| Woźniak, M | 1 |
| Mazur-Marzec, H | 1 |
| Ma, Y | 1 |
| McClatchy, DB | 1 |
| Barkallah, S | 1 |
| Wood, WW | 1 |
| Yates, JR | 1 |
| Floyd, RA | 1 |
| Castro Faria Neto, HC | 1 |
| Zimmerman, GA | 1 |
| Hensley, K | 1 |
| Towner, RA | 1 |
| Liou, B | 1 |
| Haffey, WD | 1 |
| Greis, KD | 1 |
| Grabowski, GA | 1 |
| Lorefice, L | 1 |
| Murru, MR | 1 |
| Fenu, G | 1 |
| Corongiu, D | 1 |
| Frau, J | 1 |
| Cuccu, S | 1 |
| Coghe, GC | 1 |
| Tranquilli, S | 1 |
| Cocco, E | 1 |
| Marrosu, MG | 1 |
| Kratter, IH | 1 |
| Zahed, H | 1 |
| Lau, A | 1 |
| Tsvetkov, AS | 1 |
| Daub, AC | 1 |
| Weiberth, KF | 1 |
| Gu, X | 1 |
| Saudou, F | 1 |
| Humbert, S | 1 |
| Yang, XW | 1 |
| Osmand, A | 1 |
| Steffan, JS | 1 |
| Masliah, E | 1 |
| Finkbeiner, S | 1 |
| Spilman, P | 1 |
| Lessard, P | 1 |
| Sattavat, M | 1 |
| Bush, C | 1 |
| Tousseyn, T | 1 |
| Huang, EJ | 1 |
| Giles, K | 1 |
| Golde, T | 1 |
| Das, P | 1 |
| Fauq, A | 1 |
| Prusiner, SB | 1 |
| Dearmond, SJ | 1 |
| Lee, JW | 1 |
| Beebe, K | 1 |
| Nangle, LA | 1 |
| Jang, J | 1 |
| Longo-Guess, CM | 1 |
| Cook, SA | 1 |
| Davisson, MT | 1 |
| Sundberg, JP | 1 |
| Schimmel, P | 1 |
| Ackerman, SL | 1 |
| Roy, H | 1 |
| Ibba, M | 1 |
| Ishii, A | 1 |
| Nonaka, T | 1 |
| Taniguchi, S | 1 |
| Saito, T | 1 |
| Arai, T | 1 |
| Mann, D | 1 |
| Iwatsubo, T | 1 |
| Hisanaga, S | 1 |
| Goedert, M | 1 |
| Hasegawa, M | 1 |
1 review available for alanine and Neurodegenerative Diseases
| Article | Year |
|---|---|
Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines.
Topics: Alanine; Antineoplastic Agents; Benzenesulfonates; Cyclic N-Oxides; Drug Combinations; Free Radicals | 2013 |
12 other studies available for alanine and Neurodegenerative Diseases
| Article | Year |
|---|---|
Studying the Parkinson's disease metabolome and exposome in biological samples through different analytical and cheminformatics approaches: a pilot study.
Topics: Aged; Alanine; Betaine; Cheminformatics; Exposome; Humans; Metabolome; Metabolomics; Neurodegenerati | 2022 |
Rapid differentiation of hiPSCs into functional oligodendrocytes using an OLIG2 synthetic modified messenger RNA.
Topics: Alanine; Humans; Induced Pluripotent Stem Cells; Neurodegenerative Diseases; Oligodendrocyte Transcr | 2022 |
Parkinson's Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine Model.
Topics: Alanine; Animals; Neurodegenerative Diseases; Oxidopamine; Parkinson Disease; Quality of Life; Rats | 2023 |
Presence of ß-N-methylamino-L-alanine in cyanobacteria and aquatic organisms from waters of Northern Poland; BMAA toxicity studies.
Topics: Alanine; Amino Acids, Diamino; Animals; Aquatic Organisms; Cyanobacteria; Neurodegenerative Diseases | 2021 |
HILAQ: A Novel Strategy for Newly Synthesized Protein Quantification.
Topics: Alanine; Cell Death; HEK293 Cells; Humans; Isotope Labeling; Neurodegenerative Diseases; Oxidative S | 2017 |
The LIMP-2/SCARB2 binding motif on acid β-glucosidase: basic and applied implications for Gaucher disease and associated neurodegenerative diseases.
Topics: Alanine; Amines; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, | 2014 |
A genetic association study of two genes linked to neurodegeneration in a Sardinian multiple sclerosis population: the TARDBP Ala382Thr mutation and C9orf72 expansion.
Topics: Adult; Aged; Aged, 80 and over; Alanine; C9orf72 Protein; Cohort Studies; DNA Repeat Expansion; DNA- | 2015 |
Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
Topics: Alanine; Animals; Aspartic Acid; Behavior, Animal; Chromosomes, Artificial, Bacterial; Disease Model | 2016 |
A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.
Topics: Administration, Oral; Alanine; Amyloid Precursor Protein Secretases; Animals; Azepines; Brain; Dendr | 2008 |
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration.
Topics: Acetylation; Alanine; Alanine-tRNA Ligase; Animals; Catalysis; Escherichia coli; Fibroblasts; Humans | 2006 |
Molecular biology: sticky end in protein synthesis.
Topics: Alanine; Alanine-tRNA Ligase; Animals; Genetic Code; Humans; Mice; Mutation; Neurodegenerative Disea | 2006 |
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.
Topics: Alanine; alpha-Synuclein; Animals; Brain; Casein Kinase II; Epitopes; Heparin; Humans; Mutation; Neu | 2007 |