alanine has been researched along with Neuroblastoma in 18 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ability of G protein-coupled receptors to regulate osmosensitive uptake of the organic osmolyte, taurine, into human SH-SY5Y neuroblastoma cells has been examined." | 7.75 | Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells. ( Banerjee, R; Fisher, SK; Foster, DJ; Heacock, AM; Vitvitsky, VM, 2009) |
| "Effects of alaproclate, an inhibitor of the uptake of serotonin, on muscarinic cholinergic responses in N1E-115 neuroblastoma cells were studied using intracellular recording techniques." | 7.67 | Alaproclate inhibits potassium currents and thereby enhances muscarinic stimulation in N1E-115 neuroblastoma cells. ( Hedlund, B, 1987) |
| "The ability of G protein-coupled receptors to regulate osmosensitive uptake of the organic osmolyte, taurine, into human SH-SY5Y neuroblastoma cells has been examined." | 3.75 | Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells. ( Banerjee, R; Fisher, SK; Foster, DJ; Heacock, AM; Vitvitsky, VM, 2009) |
| "The role of glutamine and alanine transport in the recycling of neurotransmitter glutamate was investigated in Guinea pig brain cortical tissue slices and prisms, and in cultured neuroblastoma and astrocyte cell lines." | 3.72 | Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation. ( Balcar, VJ; Bröer, A; Bröer, S; Bubb, WA; Conigrave, AD; Hare, N; McEwan, SR; McQuillan, JA; Rae, C, 2003) |
| " The spectra from meningiomas, neuroblastomas, and glioblastomas displayed, in addition to similarities-including the presence of signals from leucine, isoleucine, valine, threonine, lactate, acetate, glutamate, choline-containing compounds and glycine-certain distinguishing metabolic features." | 3.69 | Characteristic metabolic profiles revealed by 1H NMR spectroscopy for three types of human brain and nervous system tumours. ( Bhakoo, KK; Florian, CL; Noble, M; Preece, NE; Williams, SR, 1995) |
| " MDA-MB-435 human breast carcinoma cells were transfected with a control expression vector (pCMVBamneo), the vector containing the wild type nm23-H1, or the nm23-H1 vector encoding mutations at the following amino acids: serine 44, a phosphorylation site; proline 96, the k-pn mutation in the Drosophila nm23 homolog that causes developmental defects; histidine 118, involved in Nm23's nucleoside diphosphate kinase activity; and serine 120, a site of mutation in human neuroblastomas and phosphorylation." | 3.69 | Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells. ( Freije, JM; MacDonald, NJ; Manrow, RE; Steeg, PS; Stracke, ML, 1996) |
| "Effects of alaproclate, an inhibitor of the uptake of serotonin, on muscarinic cholinergic responses in N1E-115 neuroblastoma cells were studied using intracellular recording techniques." | 3.67 | Alaproclate inhibits potassium currents and thereby enhances muscarinic stimulation in N1E-115 neuroblastoma cells. ( Hedlund, B, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Videira, RA | 1 |
| Andrade, PB | 1 |
| Monteiro, LS | 1 |
| Valentão, P | 1 |
| Ferreira, PMT | 1 |
| Pereira, DM | 1 |
| Melo, TQ | 1 |
| van Zomeren, KC | 1 |
| Ferrari, MF | 1 |
| Boddeke, HW | 1 |
| Copray, JC | 1 |
| Abalos, GC | 1 |
| Cruite, JT | 1 |
| Bellon, A | 1 |
| Hemmers, S | 1 |
| Akagi, J | 1 |
| Mastrianni, JA | 1 |
| Williamson, RA | 1 |
| Solforosi, L | 1 |
| Foster, DJ | 1 |
| Vitvitsky, VM | 1 |
| Banerjee, R | 1 |
| Heacock, AM | 1 |
| Fisher, SK | 1 |
| Marongiu, R | 1 |
| Spencer, B | 1 |
| Crews, L | 1 |
| Adame, A | 1 |
| Patrick, C | 1 |
| Trejo, M | 1 |
| Dallapiccola, B | 1 |
| Valente, EM | 1 |
| Masliah, E | 1 |
| Allen, MJ | 1 |
| Lacroix, JJ | 1 |
| Ramachandran, S | 1 |
| Capone, R | 1 |
| Whitlock, JL | 1 |
| Ghadge, GD | 1 |
| Arnsdorf, MF | 1 |
| Roos, RP | 1 |
| Lal, R | 1 |
| Rae, C | 1 |
| Hare, N | 1 |
| Bubb, WA | 1 |
| McEwan, SR | 1 |
| Bröer, A | 1 |
| McQuillan, JA | 1 |
| Balcar, VJ | 1 |
| Conigrave, AD | 1 |
| Bröer, S | 1 |
| Parsons, MJ | 1 |
| D'Souza, UM | 1 |
| Arranz, MJ | 1 |
| Kerwin, RW | 1 |
| Makoff, AJ | 1 |
| Koh, SH | 1 |
| Lee, YB | 1 |
| Kim, KS | 1 |
| Kim, HJ | 1 |
| Kim, M | 1 |
| Lee, YJ | 1 |
| Kim, J | 1 |
| Lee, KW | 1 |
| Kim, SH | 1 |
| Schulz, I | 1 |
| Zeitschel, U | 1 |
| Rudolph, T | 1 |
| Ruiz-Carrillo, D | 1 |
| Rahfeld, JU | 1 |
| Gerhartz, B | 1 |
| Bigl, V | 1 |
| Demuth, HU | 1 |
| Rossner, S | 1 |
| Mazei-Robison, MS | 1 |
| Blakely, RD | 1 |
| Lee, RK | 1 |
| Wurtman, RJ | 1 |
| Cox, AJ | 1 |
| Nitsch, RM | 1 |
| Florian, CL | 1 |
| Preece, NE | 1 |
| Bhakoo, KK | 1 |
| Williams, SR | 1 |
| Noble, M | 1 |
| MacDonald, NJ | 1 |
| Freije, JM | 1 |
| Stracke, ML | 1 |
| Manrow, RE | 1 |
| Steeg, PS | 1 |
| Sorrentino, G | 1 |
| Singh, IN | 1 |
| Massarelli, R | 1 |
| Kanfer, JN | 1 |
| Goodall, AR | 1 |
| Turner, NA | 1 |
| Walker, JH | 1 |
| Ball, SG | 1 |
| Vaughan, PF | 1 |
| Hedlund, B | 1 |
| Imashuku, S | 1 |
| Labrosse, EH | 1 |
| Johnson, EM | 1 |
| Morgenroth, VH | 1 |
| Zenker, N | 1 |
18 other studies available for alanine and Neuroblastoma
| Article | Year |
|---|---|
Toxicity and structure-activity relationship (SAR) of α,β-dehydroamino acids against human cancer cell lines.
Topics: Alanine; Antineoplastic Agents; Apoptosis; Caspases; Cell Line; Cell Line, Tumor; Cell Shape; Drug D | 2018 |
Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson's disease.
Topics: Alanine; alpha-Synuclein; Cell Differentiation; Cell Line, Tumor; Gene Expression Regulation; Humans | 2017 |
Identifying key components of the PrPC-PrPSc replicative interface.
Topics: Alanine; Animals; Cell Line, Tumor; Epitopes; Flow Cytometry; Mice; Mutation; Neuroblastoma; Peptide | 2008 |
Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells.
Topics: Alanine; Antioxidants; Biological Transport; Calcium; Cell Line, Tumor; Cyclopentanes; Dose-Response | 2009 |
Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux.
Topics: Adenosine Triphosphate; Alanine; alpha-Synuclein; Analysis of Variance; Animals; Calcium; Cell Line, | 2009 |
Mutant SOD1 forms ion channel: implications for ALS pathophysiology.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Biophysical Phenomena; Biophysics; Calcium; Cell Li | 2012 |
Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation.
Topics: Acetic Acid; Alanine; Animals; Astrocytes; beta-Alanine; Biological Transport; Carbon Isotopes; Cell | 2003 |
The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity.
Topics: Alanine; Cell Line, Tumor; Chloramphenicol O-Acetyltransferase; Cysteine; Genes, Reporter; Glycine; | 2004 |
Role of GSK-3beta activity in motor neuronal cell death induced by G93A or A4V mutant hSOD1 gene.
Topics: Alanine; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Death; Cell Differentiatio | 2005 |
Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion.
Topics: Alanine; Cell Line, Tumor; Fluoresceins; Glioma; Green Fluorescent Proteins; Humans; Immunohistochem | 2005 |
Expression studies of naturally occurring human dopamine transporter variants identifies a novel state of transporter inactivation associated with Val382Ala.
Topics: Alanine; Amphetamine; Animals; Biotinylation; Cattle; Cell Line; Chlorocebus aethiops; Cocaine; COS | 2005 |
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Chelating Agents | 1995 |
Characteristic metabolic profiles revealed by 1H NMR spectroscopy for three types of human brain and nervous system tumours.
Topics: Alanine; Amino Acids; Brain Neoplasms; Choline; Chromatography, High Pressure Liquid; Creatine; Glio | 1995 |
Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells.
Topics: Alanine; Amino Acid Sequence; Animals; Breast Neoplasms; Cell Division; Chemotaxis; Drosophila; Fema | 1996 |
Stimulation of phospholipase C activity by norepinephrine, t-ACPD and bombesin in LA-N-2 cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alanine; Bombesin; Cycloleucine; Excitatory A | 1996 |
Activation of protein kinase C-alpha and translocation of the myristoylated alanine-rich C-kinase substrate correlate with phorbol ester-enhanced noradrenaline release from SH-SY5Y human neuroblastoma cells.
Topics: Alanine; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Isoenzymes; Membr | 1997 |
Alaproclate inhibits potassium currents and thereby enhances muscarinic stimulation in N1E-115 neuroblastoma cells.
Topics: Alanine; Antidepressive Agents; Calcium Radioisotopes; Carbachol; Cells, Cultured; Ion Channels; Mem | 1987 |
Tyrosine hydroxylase in neuroblastoma.
Topics: Adrenal Glands; Alanine; Animals; Benzimidazoles; Cattle; Child, Preschool; Dihydroxyphenylalanine; | 1971 |