alanine has been researched along with Nerve Degeneration in 27 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats." | 7.80 | The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014) |
| " Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats." | 3.80 | The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014) |
| "Safinamide or vehicle was delivered from days 0 or 1, for 7 days, via sub-cutaneous mini-pumps." | 1.43 | Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson's disease. ( Mullali, G; Piers, T; Pocock, JM; Roach, A; Sadeghian, M; Smith, KJ, 2016) |
| " Agonists of the glycine recognition site of NMDA receptors (D-serine and D-alanine) did not have any toxic effect in hippocampal cultures, whereas competitive blockade of the glycine site by 7-chlorokynurenic acid was neuroprotective." | 1.33 | Glycine-induced neurotoxicity in organotypic hippocampal slice cultures. ( Barth, A; Barth, L; Newell, DW; Nguyen, LB, 2005) |
| "Glycine levels were reduced by 9% in dorsolateral laminae VII and IX." | 1.27 | Amino acid levels in the guinea pig spinal gray matter after axotomy of primary sensory and descending tracts. ( Dymczyk, L; Potashner, SJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (18.52) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Sonobe, Y | 1 |
| Aburas, J | 1 |
| Krishnan, G | 1 |
| Fleming, AC | 1 |
| Ghadge, G | 1 |
| Islam, P | 1 |
| Warren, EC | 1 |
| Gu, Y | 1 |
| Kankel, MW | 1 |
| Brown, AEX | 1 |
| Kiskinis, E | 1 |
| Gendron, TF | 1 |
| Gao, FB | 1 |
| Roos, RP | 1 |
| Kratsios, P | 1 |
| Stayte, S | 1 |
| Laloli, KJ | 1 |
| Rentsch, P | 1 |
| Lowth, A | 1 |
| Li, KM | 1 |
| Pickford, R | 1 |
| Vissel, B | 1 |
| Wang, C | 1 |
| Zhang, M | 1 |
| Garcia, G | 1 |
| Tian, E | 1 |
| Cui, Q | 1 |
| Chen, X | 1 |
| Sun, G | 1 |
| Wang, J | 1 |
| Arumugaswami, V | 1 |
| Shi, Y | 1 |
| Radu, AG | 1 |
| Torch, S | 1 |
| Fauvelle, F | 1 |
| Pernet-Gallay, K | 1 |
| Lucas, A | 1 |
| Blervaque, R | 1 |
| Delmas, V | 1 |
| Schlattner, U | 1 |
| Lafanechère, L | 1 |
| Hainaut, P | 1 |
| Tricaud, N | 1 |
| Pingault, V | 1 |
| Bondurand, N | 1 |
| Bardeesy, N | 1 |
| Larue, L | 1 |
| Thibert, C | 1 |
| Billaud, M | 1 |
| Apland, JP | 1 |
| Aroniadou-Anderjaska, V | 1 |
| Figueiredo, TH | 1 |
| Rossetti, F | 1 |
| Miller, SL | 1 |
| Braga, MF | 1 |
| Sadeghian, M | 1 |
| Mullali, G | 1 |
| Pocock, JM | 1 |
| Piers, T | 1 |
| Roach, A | 1 |
| Smith, KJ | 1 |
| Laroche-Pierre, S | 1 |
| Jodoin, J | 1 |
| LeBlanc, AC | 1 |
| Gu, X | 1 |
| Greiner, ER | 1 |
| Mishra, R | 1 |
| Kodali, R | 1 |
| Osmand, A | 1 |
| Finkbeiner, S | 1 |
| Steffan, JS | 1 |
| Thompson, LM | 1 |
| Wetzel, R | 1 |
| Yang, XW | 1 |
| Finn, R | 1 |
| Kovács, AD | 1 |
| Pearce, DA | 1 |
| Quadri, M | 1 |
| Cossu, G | 1 |
| Saddi, V | 1 |
| Simons, EJ | 1 |
| Murgia, D | 1 |
| Melis, M | 1 |
| Ticca, A | 1 |
| Oostra, BA | 1 |
| Bonifati, V | 1 |
| Graça, CR | 1 |
| Paschoal, VD | 1 |
| Cordeiro-Soubhia, RM | 1 |
| Tonelli-Nardi, SM | 1 |
| Machado, RL | 1 |
| Kouyoumdjian, JA | 1 |
| Baptista Rossit, AR | 1 |
| Bajsarowicz, K | 1 |
| Ahn, M | 1 |
| Ackerman, L | 1 |
| Dearmond, BN | 1 |
| Carlson, G | 1 |
| DeArmond, SJ | 1 |
| Barth, A | 1 |
| Nguyen, LB | 1 |
| Barth, L | 1 |
| Newell, DW | 1 |
| Martin, LJ | 1 |
| Pan, Y | 1 |
| Price, AC | 1 |
| Sterling, W | 1 |
| Copeland, NG | 1 |
| Jenkins, NA | 1 |
| Price, DL | 1 |
| Lee, MK | 1 |
| Park, SS | 1 |
| Schulz, EM | 1 |
| Lee, D | 1 |
| Casey, PA | 1 |
| McKenna, MC | 1 |
| Fiskum, G | 1 |
| Saraswati, M | 1 |
| Robertson, CL | 1 |
| Maginn, M | 1 |
| Caldwell, M | 1 |
| Kelly, JP | 1 |
| Leonard, BE | 1 |
| Riepe, M | 1 |
| Spencer, PS | 1 |
| Lambein, F | 1 |
| Ludolph, AC | 1 |
| Allen, CN | 1 |
| Price, MT | 1 |
| Romano, C | 1 |
| Fix, AS | 1 |
| Tizzano, JP | 1 |
| Olney, JW | 2 |
| Bruno, V | 1 |
| Copani, A | 1 |
| Bonanno, L | 1 |
| Knoepfel, T | 1 |
| Kuhn, R | 1 |
| Roberts, PJ | 2 |
| Nicoletti, F | 1 |
| Ooboshi, H | 1 |
| Ibayashi, S | 1 |
| Takano, K | 1 |
| Sadoshima, S | 1 |
| Kondo, A | 1 |
| Uchimura, H | 1 |
| Fujishima, M | 1 |
| Collins, GG | 1 |
| Schousboe, A | 1 |
| Westergaard, N | 1 |
| Sonnewald, U | 1 |
| Petersen, SB | 1 |
| Yu, AC | 1 |
| Hertz, L | 1 |
| Potashner, SJ | 1 |
| Dymczyk, L | 1 |
| McBride, WJ | 1 |
| Ghetti, B | 1 |
| Ho, OL | 1 |
| Rhee, V | 1 |
| Keen, P | 1 |
1 review available for alanine and Nerve Degeneration
| Article | Year |
|---|---|
Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA.
Topics: Alanine; Amino Acids; Animals; Astrocytes; Brain; Cell Communication; Epilepsy; gamma-Aminobutyric A | 1992 |
26 other studies available for alanine and Nerve Degeneration
| Article | Year |
|---|---|
A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Arginine; C9orf72 Protein; Caenorhabditis elegans; | 2021 |
The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain.
Topics: Alanine; Animals; Dopaminergic Neurons; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Mesencephalo | 2020 |
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Apolipoproteins E; Astrocytes; Brain; C | 2021 |
LKB1 specifies neural crest cell fates through pyruvate-alanine cycling.
Topics: Alanine; AMP-Activated Protein Kinases; Animals; Cell Differentiation; Energy Metabolism; Enteric Ne | 2019 |
The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.
Topics: Alanine; Amygdala; Animals; Anticonvulsants; Anxiety; Diazepam; Hippocampus; Male; Nerve Degeneratio | 2014 |
Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson's disease.
Topics: Alanine; Animals; Benzylamines; Dopaminergic Neurons; Male; Microglia; Nerve Degeneration; Neuroprot | 2016 |
Helix 3 is necessary and sufficient for prion protein's anti-Bax function.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Apoptosis; bcl-2-Associated X Protei | 2009 |
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Aspartic Acid; Disease Mode | 2009 |
Altered sensitivity to excitotoxic cell death and glutamate receptor expression between two commonly studied mouse strains.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell D | 2010 |
Broadening the phenotype of TARDBP mutations: the TARDBP Ala382Thr mutation and Parkinson's disease in Sardinia.
Topics: Aged; Alanine; Amino Acid Substitution; Case-Control Studies; Cohort Studies; DNA Mutational Analysi | 2011 |
NINJURIN1 single nucleotide polymorphism and nerve damage in leprosy.
Topics: Adenine; Adult; Aged; Alanine; Alleles; Asparagine; Case-Control Studies; Cell Adhesion Molecules, N | 2012 |
A brain aggregate model gives new insights into the pathobiology and treatment of prion diseases.
Topics: Alanine; Animals; Azepines; Brain; Cathepsin D; Dendrites; Disease Models, Animal; Embryo, Mammalian | 2012 |
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Dose-Response Relationship, Drug; Drug Resistanc | 2005 |
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.
Topics: Alanine; alpha-Synuclein; Animals; Brain Stem; Cell Death; DNA Damage; Humans; Mice; Mice, Transgeni | 2006 |
Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein.
Topics: Alanine; alpha-Methyltyrosine; alpha-Synuclein; Animals; Animals, Genetically Modified; Cells, Cultu | 2007 |
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C | 2008 |
The effect of 2-amino-3-phosphonopropionic acid (AP-3) in the gerbil model of cerebral ischaemia.
Topics: Alanine; Animals; Brain Ischemia; Gerbillinae; Male; Motor Activity; Nerve Degeneration; Neurons; Re | 1995 |
In vitro toxicological investigations of isoxazolinone amino acids of Lathyrus sativus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Aminobutyrates; Animals; Electrophysiology; Hippocamp | 1995 |
Blockade of the second messenger functions of the glutamate metabotropic receptor is associated with degenerative changes in the retina and brain of immature rodents.
Topics: Alanine; Animals; Animals, Newborn; Asparagine; Brain Diseases; Excitatory Amino Acid Antagonists; I | 1995 |
Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures.
Topics: Alanine; Animals; Cells, Cultured; Cerebral Cortex; Mice; N-Methylaspartate; Nerve Degeneration; Neu | 1996 |
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Ex | 2000 |
Effect of chronic bulbectomy on the depth distribution of amino acid transmitter candidates in rat olfactory cortex.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Denervation; gamma-Aminobutyric Acid; | 1979 |
Amino acid levels in the guinea pig spinal gray matter after axotomy of primary sensory and descending tracts.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Axons; gamma-Aminobutyric Acid; Glutamates; Glutamic A | 1986 |
Changes in the content of glutamate and GABA in the cerebellar vermis and hemispheres of the Purkinje cell degeneration (pcd) mutant.
Topics: Alanine; Animals; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Mice; Mic | 1988 |
Brain-damaging potential of protein hydrolysates.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Damage, Chronic; Caseins; Fibrin; Glutamates; Hu | 1973 |
Effect of dorsal root section on amino acids of rat spinal cord.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Carbon Radioisotopes; Centrifugation, | 1974 |