alanine has been researched along with Neoplasm Metastasis in 21 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors conducted a phase II study of L-alanosine in 39 patients (19 without prior chemotherapy) in advanced malignant melanoma." | 7.67 | Phase II evaluation of L-alanosine (NSC-153353) for patients with disseminated malignant melanoma. ( Ahmann, DL; Creagan, ET; Green, SJ; Long, HJ, 1984) |
| "The authors conducted a phase II study of L-alanosine in 39 patients (19 without prior chemotherapy) in advanced malignant melanoma." | 3.67 | Phase II evaluation of L-alanosine (NSC-153353) for patients with disseminated malignant melanoma. ( Ahmann, DL; Creagan, ET; Green, SJ; Long, HJ, 1984) |
| " Most toxic effects were mild." | 2.76 | A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors. ( de Braud, F; Feltquate, DM; Galbraith, S; Goss, G; Jayson, GC; Jonker, DJ; Kantor, J; Kollia, G; McArthur, GA; Mokliatchouk, O; Nuyten, DSA; Rosen, LS; Rustin, G; Sawyer, MB; Sweeney, CJ; Syed, S; Velasquez, L; Wilding, G, 2011) |
| " Throughout both phases, subjects were evaluated for adverse events (AEs) and best clinical response." | 2.76 | Lack of food effect on single-dose pharmacokinetics of brivanib, and safety and efficacy following multiple doses in subjects with advanced or metastatic solid tumors. ( Chemidlin, J; Fischer, B; Hurwitz, H; Kollia, G; LoRusso, P; Masson, E; Pilat, MJ; Shapiro, GI; Syed, S, 2011) |
| " The median time to reach the maximal plasma concentration of brivanib was 1 h, geometric mean maximal plasma concentration was 6146 ng/ml, mean terminal half-life was 13." | 2.75 | Metabolism, excretion, and pharmacokinetics of oral brivanib in patients with advanced or metastatic solid tumors. ( Fischer, BS; Gan, J; Ganapathi, R; Gong, J; Iyer, R; Masson, E; Mekhail, T; Patricia, D; Pursley, J; Williams, D, 2010) |
| "A network meta-analysis was conducted comparing the short-term efficacies of 16 targeted drugs in combination with chemotherapy for treatment of advanced/metastatic colorectal cancer (CRC)." | 2.53 | A network meta-analysis on the efficacy of sixteen targeted drugs in combination with chemotherapy for treatment of advanced/metastatic colorectal cancer. ( Ba-Sang, DZ; Li, MS; Long, ZW; Qiu, J; Teng, H; Zhao, XP, 2016) |
| "The anti-tumor and anti-metastases activity of Msurvivin T34A plasmid complexed with cationic liposome (DOTAP/Chol) was evaluated in female BALB/c mice bearing 4T1 s." | 1.35 | Efficient inhibition of murine breast cancer growth and metastasis by gene transferred mouse survivin Thr34-->Ala mutant. ( Chen, LJ; Liu, JY; Mao, YQ; Peng, XC; Wei, YQ; Yang, HS; Yang, L; Yang, LP; Zhang, DM, 2008) |
| "To assess the effect on metastasis, XV454 was administered intravenous or orally 10 minutes and 3 hrs before tumor cell injection, respectively." | 1.32 | Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454. ( Amaya, M; Amirkhosravi, A; Blaydes, S; Desai, H; Francis, JL; Meyer, T; Mousa, SA, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (28.57) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roviello, GN | 1 |
| Iannitti, R | 1 |
| Palumbo, R | 1 |
| Simonyan, H | 1 |
| Vicidomini, C | 1 |
| Roviello, V | 1 |
| Wasinger, C | 1 |
| Hofer, A | 1 |
| Spadiut, O | 1 |
| Hohenegger, M | 1 |
| Wells, JC | 1 |
| Tu, D | 1 |
| Siu, LL | 1 |
| Shapiro, JD | 1 |
| Jonker, DJ | 2 |
| Karapetis, C | 1 |
| Simes, J | 1 |
| Liu, G | 1 |
| Price, TJ | 1 |
| Tebbutt, NC | 1 |
| O'Callaghan, CJ | 1 |
| Ba-Sang, DZ | 1 |
| Long, ZW | 1 |
| Teng, H | 1 |
| Zhao, XP | 1 |
| Qiu, J | 1 |
| Li, MS | 1 |
| Häggblad Sahlberg, S | 1 |
| Mortensen, AC | 1 |
| Haglöf, J | 1 |
| Engskog, MK | 1 |
| Arvidsson, T | 1 |
| Pettersson, C | 1 |
| Glimelius, B | 1 |
| Stenerlöw, B | 1 |
| Nestor, M | 1 |
| Peng, XC | 1 |
| Yang, L | 1 |
| Yang, LP | 1 |
| Mao, YQ | 1 |
| Yang, HS | 1 |
| Liu, JY | 1 |
| Zhang, DM | 1 |
| Chen, LJ | 1 |
| Wei, YQ | 1 |
| Mekhail, T | 1 |
| Masson, E | 2 |
| Fischer, BS | 1 |
| Gong, J | 1 |
| Iyer, R | 1 |
| Gan, J | 1 |
| Pursley, J | 1 |
| Patricia, D | 1 |
| Williams, D | 1 |
| Ganapathi, R | 1 |
| Rosen, LS | 1 |
| Sawyer, MB | 1 |
| de Braud, F | 1 |
| Wilding, G | 1 |
| Sweeney, CJ | 1 |
| Jayson, GC | 1 |
| McArthur, GA | 1 |
| Rustin, G | 1 |
| Goss, G | 1 |
| Kantor, J | 1 |
| Velasquez, L | 1 |
| Syed, S | 2 |
| Mokliatchouk, O | 1 |
| Feltquate, DM | 1 |
| Kollia, G | 2 |
| Nuyten, DSA | 1 |
| Galbraith, S | 1 |
| LoRusso, P | 1 |
| Shapiro, GI | 1 |
| Hurwitz, H | 1 |
| Pilat, MJ | 1 |
| Chemidlin, J | 1 |
| Fischer, B | 1 |
| Amirkhosravi, A | 1 |
| Mousa, SA | 1 |
| Amaya, M | 1 |
| Blaydes, S | 1 |
| Desai, H | 1 |
| Meyer, T | 1 |
| Francis, JL | 1 |
| Yin, S | 1 |
| Li, X | 1 |
| Meng, Y | 1 |
| Finley, RL | 1 |
| Sakr, W | 1 |
| Yang, H | 1 |
| Reddy, N | 1 |
| Sheng, S | 1 |
| Sorokina, IV | 1 |
| Tolstikova, TG | 1 |
| Zhukova, NA | 1 |
| Petrenko, NI | 1 |
| Uzenkova, NV | 1 |
| Shul'ts, EE | 1 |
| Popova, NA | 1 |
| Li, C | 1 |
| Collier, ME | 1 |
| Frentzou, GA | 1 |
| Greenman, J | 1 |
| Ettelaie, C | 1 |
| Creagan, ET | 1 |
| Long, HJ | 1 |
| Ahmann, DL | 1 |
| Green, SJ | 1 |
| Pei, L | 1 |
| Melmed, S | 1 |
| Scheithauer, B | 1 |
| Kovacs, K | 1 |
| Prager, D | 1 |
| Hartsough, MT | 1 |
| Morrison, DK | 1 |
| Salerno, M | 1 |
| Palmieri, D | 1 |
| Ouatas, T | 1 |
| Mair, M | 1 |
| Patrick, J | 1 |
| Steeg, PS | 1 |
| Bornschein, W | 1 |
| Elson, PJ | 1 |
| Kvols, LK | 1 |
| Vogl, SE | 1 |
| Glover, DJ | 1 |
| Hahn, RG | 1 |
| Trump, DL | 1 |
| Carbone, PP | 1 |
| Earle, JD | 1 |
| Davis, TE | 1 |
| Mulay, AS | 1 |
| O'Gara, RW | 1 |
| Peters, JE | 1 |
| Nilius, R | 1 |
| Otto, L | 1 |
| Bojan, O | 1 |
| Mustea, I | 1 |
| Preda, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Dose Escalation Study to Determine the Safety, Pharmacokinetics and Pharmacodynamics of BMS-582664 in Combination With Full Dose Erbitux in Patients With Advanced Gastrointestinal Malignancies Who Have Failed Prior Therapy[NCT00207051] | Phase 1 | 62 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for alanine and Neoplasm Metastasis
| Article | Year |
|---|---|
A network meta-analysis on the efficacy of sixteen targeted drugs in combination with chemotherapy for treatment of advanced/metastatic colorectal cancer.
Topics: Alanine; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothe | 2016 |
3 trials available for alanine and Neoplasm Metastasis
| Article | Year |
|---|---|
Metabolism, excretion, and pharmacokinetics of oral brivanib in patients with advanced or metastatic solid tumors.
Topics: Administration, Oral; Aged; Alanine; Antineoplastic Agents; Chromatography, High Pressure Liquid; Do | 2010 |
A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Angiogenesis Inhibitors; Antineoplastic Agents; Dose-Respon | 2011 |
Lack of food effect on single-dose pharmacokinetics of brivanib, and safety and efficacy following multiple doses in subjects with advanced or metastatic solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Antineoplastic Agents; Cross-Over Studies; Female; Food; Hu | 2011 |
17 other studies available for alanine and Neoplasm Metastasis
| Article | Year |
|---|---|
Lac-L-TTA, a novel lactose-based amino acid-sugar conjugate for anti-metastatic applications.
Topics: Alanine; Amino Acids; Antineoplastic Agents; Cell Proliferation; Colony-Forming Units Assay; Humans; | 2017 |
Amino Acid Signature in Human Melanoma Cell Lines from Different Disease Stages.
Topics: Alanine; Amino Acids; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Huma | 2018 |
Outcomes of Older Patients (≥ 70 Years) Treated With Targeted Therapy in Metastatic Chemorefractory Colorectal Cancer: Retrospective Analysis of NCIC CTG CO.17 and CO.20.
Topics: Age Factors; Aged; Alanine; Antineoplastic Combined Chemotherapy Protocols; Cetuximab; Clinical Tria | 2019 |
Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells.
Topics: Alanine; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Fatty Ac | 2017 |
Efficient inhibition of murine breast cancer growth and metastasis by gene transferred mouse survivin Thr34-->Ala mutant.
Topics: Alanine; Amino Acid Substitution; Animals; Fatty Acids, Monounsaturated; Female; Gene Transfer Techn | 2008 |
Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454.
Topics: Administration, Oral; Alanine; Animals; Carcinoma, Lewis Lung; Cell Line, Tumor; Drug Evaluation, Pr | 2003 |
Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase.
Topics: Alanine; Arginine; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Separation; DNA, Comp | 2005 |
Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable lewis carcinoma.
Topics: Alanine; Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Male; Mice; Mice, Inbred C57BL; Neop | 2006 |
Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity.
Topics: Alanine; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Immune System; Models, Bi | 2008 |
Phase II evaluation of L-alanosine (NSC-153353) for patients with disseminated malignant melanoma.
Topics: Alanine; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Male; Melanoma; Middle Aged; | 1984 |
H-ras mutations in human pituitary carcinoma metastases.
Topics: Adenoma; Alanine; Arginine; Base Sequence; DNA, Neoplasm; Exons; Genes, p53; Genes, ras; Glycine; Hu | 1994 |
Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway.
Topics: Alanine; Amino Acid Substitution; Antigens, Neoplasm; Base Sequence; Breast Neoplasms; Cell Line; DN | 2002 |
[Isoenzymes of alaninarylamidase and gamma-glutamyl-transpeptidase in intrahepatic and extra-hepatic cholostasis (author's transl)].
Topics: Alanine; Bile Duct Neoplasms; Cholestasis; Diagnosis, Differential; Electrophoresis, Agar Gel; gamma | 1975 |
Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma.
Topics: Adult; Aged; Alanine; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Administration Schedule; Dr | 1988 |
Effect of diet on N,N-dimethyl-p-(m-tolylazo)aniline carcinogenesis in rats.
Topics: Alanine; Animals; Carcinoma, Hepatocellular; Diet; Female; Liver; Liver Neoplasms; Male; Neoplasm Me | 1971 |
[Electrophoretic variants of alanine aminopeptidase in serum of patients with hepatobiliary diseases].
Topics: Alanine; Aminopeptidases; Biliary Tract Diseases; Electrophoresis; Gallbladder Diseases; Hepatitis; | 1973 |
[Modification of some free amino acids in the serum of cancer patients under the influence of glucose on tumoral metabolism].
Topics: Alanine; Amino Acids; Breast Neoplasms; Chromatography, Paper; Dietary Carbohydrates; Dietary Protei | 1969 |