alanine has been researched along with Muscular Atrophy in 8 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Muscular Atrophy: Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of gyrate atrophy of the choroid and retina associated with hyperornithinemia has been subjected to extensive clinical and biochemical investigation." | 3.65 | Gyrate atrophy of the choroid and retina: clinical, ophthalmologic, and biochemical considerations. ( Marliss, EB; McCulloch, C, 1975) |
| "Skeletal muscle atrophy occurs in response to various pathophysiological stimuli, including disuse, aging, and neuromuscular disorders, mainly due to an imbalance of anabolic/catabolic signaling." | 1.62 | BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading. ( Allegretti, M; Aramini, A; Bianchini, G; Boccanegra, B; Camerino, GM; Cappellari, O; Conte, E; De Bellis, M; De Luca, A; Mantuano, P; Pierno, S; Sanarica, F, 2021) |
| "All patients with spinal muscular atrophy and congenital myopathy and one patient with Duchenne dystrophy, but none of six healthy subjects, developed hypoglycemia." | 1.32 | Patients with severe muscle wasting are prone to develop hypoglycemia during fasting. ( Hebert, A; Laub, M; Vissing, J; Zacho, M; Ørngreen, MC, 2003) |
| " Rats were given hydrocortisone 21-acetate or the dosing vehicle and were infused with alanine (AA) or alanyl-glutamine (AG) at the same concentrations and rates (1." | 1.29 | Alanyl-glutamine prevents muscle atrophy and glutamine synthetase induction by glucocorticoids. ( Hickson, RC; Karl, IE; Osborne, DF; Wegrzyn, LE, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Okun, JG | 1 |
| Rusu, PM | 1 |
| Chan, AY | 1 |
| Wu, Y | 1 |
| Yap, YW | 1 |
| Sharkie, T | 1 |
| Schumacher, J | 1 |
| Schmidt, KV | 1 |
| Roberts-Thomson, KM | 1 |
| Russell, RD | 1 |
| Zota, A | 1 |
| Hille, S | 1 |
| Jungmann, A | 1 |
| Maggi, L | 1 |
| Lee, Y | 1 |
| Blüher, M | 1 |
| Herzig, S | 1 |
| Keske, MA | 1 |
| Heikenwalder, M | 1 |
| Müller, OJ | 1 |
| Rose, AJ | 1 |
| Morris, A | 1 |
| Mantuano, P | 1 |
| Boccanegra, B | 1 |
| Bianchini, G | 1 |
| Conte, E | 1 |
| De Bellis, M | 1 |
| Sanarica, F | 1 |
| Camerino, GM | 1 |
| Pierno, S | 1 |
| Cappellari, O | 1 |
| Allegretti, M | 1 |
| Aramini, A | 1 |
| De Luca, A | 1 |
| Bevington, A | 1 |
| Brown, J | 1 |
| Butler, H | 1 |
| Govindji, S | 1 |
| M-Khalid, K | 1 |
| Sheridan, K | 1 |
| Walls, J | 1 |
| Ørngreen, MC | 1 |
| Zacho, M | 1 |
| Hebert, A | 1 |
| Laub, M | 1 |
| Vissing, J | 1 |
| Kochanski, A | 1 |
| Drac, H | 1 |
| Kabzińska, D | 1 |
| Hausmanowa-Petrusewicz, I | 1 |
| Hickson, RC | 1 |
| Wegrzyn, LE | 1 |
| Osborne, DF | 1 |
| Karl, IE | 1 |
| McCulloch, C | 1 |
| Marliss, EB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics and Safety of Treatment With Paracetamol in Children and Adults With Spinal Muscular Atrophy and Cerebral Palsy[NCT03648658] | Phase 4 | 48 participants (Anticipated) | Interventional | 2019-02-18 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for alanine and Muscular Atrophy
| Article | Year |
|---|---|
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
Topics: Alanine; Alanine Transaminase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, An | 2021 |
Linking liver alanine metabolism and muscle atrophy.
Topics: Alanine; Humans; Liver; Muscular Atrophy | 2021 |
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading.
Topics: Alanine; Amino Acids, Branched-Chain; Animals; Dipeptides; Disease Models, Animal; Hindlimb Suspensi | 2021 |
Impaired system A amino acid transport mimics the catabolic effects of acid in L6 cells.
Topics: Alanine; Amino Acid Transport System A; Animals; Biological Transport; Deoxyglucose; Glycolysis; Hyd | 2002 |
Patients with severe muscle wasting are prone to develop hypoglycemia during fasting.
Topics: Adult; Alanine; Blood Glucose; Body Weight; Fasting; Fatty Acids, Nonesterified; Female; Glycerol; H | 2003 |
A novel mutation, Thr65Ala, in the MPZ gene in a patient with Charcot-Marie-Tooth type 1B disease with focally folded myelin.
Topics: Adult; Alanine; Charcot-Marie-Tooth Disease; DNA Mutational Analysis; Female; Hand Deformities; Huma | 2004 |
Alanyl-glutamine prevents muscle atrophy and glutamine synthetase induction by glucocorticoids.
Topics: Alanine; Animals; Body Weight; Dipeptides; Enzyme Induction; Female; Glucocorticoids; Glutamate-Ammo | 1996 |
Gyrate atrophy of the choroid and retina: clinical, ophthalmologic, and biochemical considerations.
Topics: Adult; Alanine; Amino Acid Metabolism, Inborn Errors; Arginine; Atrophy; Cataract; Choroid; Histidin | 1975 |